JP2021500531A - 化学的および生物学的検体の検出に有用なスキャン装置および方法 - Google Patents
化学的および生物学的検体の検出に有用なスキャン装置および方法 Download PDFInfo
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Abstract
Description
この出願は、2017年8月15日に出願された「SCANNING APPARATUS AND METHODS USEFUL FOR DETECTION OF CHEMICAL AND BIOLOGICAL ANALYTES」と題された米国特許仮出願第62/545,606号の優先権を主張し、これらはそれぞれの全体が参照により本明細書に組み込まれる。
Claims (57)
- 検出装置であって、
(a)管腔および壁を備える容器であって、前記壁が、内面および外面を備え、前記内面が、前記管腔に接触する、容器と、
(b)検出器とともに構造ループを形成する基準面と、
(c)前記容器の前記外面を付勢して前記基準面上の領域に接触させるように構成された予荷重と、
(d)スキャン次元で前記基準面に沿って前記容器をスライドさせるように構成されたスキャンアクチュエータと、
(e)前記容器の前記外面が、前記基準面に接触するように、前記予荷重によって付勢されたときに、前記内面または前記管腔からの信号を前記検出器に方向付けるように構成された送信器と、を備える、検出装置。 - 前記予荷重が、前記容器に引っ張り力または押し込み力を生成するように構成される、請求項1に記載の装置。
- 前記予荷重が、前記基準面と前記容器との間の前記接触の領域よりも大きくない、前記容器との接触領域を有する、請求項1〜2のいずれか一項に記載の装置。
- 前記予荷重が、前記容器と接触するように構成された圧縮性材料、または前記容器と接触するように構成された少なくとも1つのボール軸受を備える、請求項1〜3のいずれか一項に記載の装置。
- 前記スキャン次元が、デカルト座標系のxy平面内にある、請求項1〜4のいずれか一項に記載の装置。
- 前記デカルト座標系のz次元における前記送信器と前記基準面との相対位置を変更するように構成されたzアクチュエータをさらに備える、請求項5に記載の装置。
- 前記スキャン次元が、前記xy平面のx次元に沿って線形である、請求項5〜6のいずれか一項に記載の装置。
- y次元に沿って前記容器および前記基準面の相対並進位置を変更するように構成されたyアクチュエータをさらに備える、請求項7に記載の装置。
- 前記外面が、スキャン次元xにおける長さlを有し、前記基準面上の前記接触の領域が、長さlよりも短い前記スキャン次元xにおける最大長さを有する、請求項7〜8のいずれか一項に記載の装置。
- 前記スキャン次元が、前記xy平面内の弓状経路である、請求項5〜9のいずれか一項に記載の装置。
- 前記送信器が、レンズのアレイを備え、前記アレイ内の各レンズが、前記xy平面内の個別領域を観察するように構成される、請求項5〜10のいずれか一項に記載の装置。
- 前記レンズのアレイ内の各レンズが、前記容器内に存在する部位のアレイ内の単一部位を観察するように構成される、請求項11に記載の装置。
- 前記スキャンアクチュエータが、前記容器の穿孔と相互作用するように構成された歯車を備える、請求項1〜12のいずれか一項に記載の装置。
- 前記スキャンアクチュエータが、前記容器の磁性構成要素または強磁性構成要素と相互作用するように構成された磁気線形駆動装置を備える、請求項1〜13のいずれか一項に記載の装置。
- 前記信号が、放射を備え、前記送信器が、光学対物レンズを備える、請求項1〜14のいずれか一項に記載の装置。
- 前記基準面が、前記対物レンズのための開口部を取り囲む、請求項15に記載の装置。
- 前記予荷重が、前記開口部を取り囲む前記基準面とは反対側にある前記容器との接触領域を有する、請求項16に記載の装置。
- 前記基準面とともに構造ループを形成する放射源をさらに備える、請求項1〜17のいずれか一項に記載の装置。
- 前記放射源は、前記容器の前記外面が、前記基準面に接触するように、前記予荷重によって付勢されたときに、前記送信器を通して、次いで、前記内面または前記管腔に、エネルギーを方向付けるように構成される、請求項18に記載の装置。
- 前記容器が、前記管腔と流体連通する入口および出口を有するフローセルを備え、前記壁の前記内面が、異なる核酸部位のアレイを備える、請求項1〜19のいずれか一項に記載の装置。
- 容器をスキャンする方法であって、
(a)検出装置の基準面に沿って容器を並進させることであって、前記容器が、管腔および壁を備え、前記管腔が、検体を備え、前記基準面が、前記並進中に、前記容器のうちの少なくとも一部分に接触し、前記基準面が、検出器とともに構造ループを形成する、並進させることと、
(b)前記検出器を使用して前記容器に沿った異なる場所で前記検体を検出することであって、前記容器が、前記検出中に、予荷重によって、前記基準面に付勢され、それにより前記容器をスキャンする、検出することと、を含む、方法。 - 前記基準面が、前記並進中の任意の時点で前記容器の長さの一部分のみに接触する、請求項21に記載の方法。
- 前記信号が、前記検体のうちの少なくとも1つによって生成される光学信号を備える、請求項21〜22のいずれか一項に記載の方法。
- 前記検出装置が、前記管腔から前記検出器に光信号を送信するように構成されている対物レンズをさらに備える、請求項23に記載の方法。
- 前記対物レンズと前記基準面との間の相対距離を変更することにより、前記対物レンズの焦点を合わせることをさらに含む、請求項24に記載の方法。
- 前記対物レンズが、前記基準面の開口部を通して前記容器を観察する、請求項24〜25のいずれか一項に記載の方法。
- 前記予荷重が、前記開口部を取り囲む前記基準面の領域とは反対側にある前記容器との接触領域を有する、請求項26に記載の方法。
- 前記並進させることが、前記容器と前記基準面との相対並進位置を直線方向または弓状方向において変更することを含む、請求項21〜27のいずれか一項に記載の方法。
- 前記並進させることが、前記容器上、または前記容器を保持するカートリッジ上の穿孔に回転歯車を接触させることを含む、請求項21〜28のいずれか一項に記載の方法。
- 前記並進させることが、線形アクチュエータと、前記容器上、または前記容器を保持するカートリッジ上の磁性材料または強磁性材料との磁気相互作用を含む、請求項21〜29のいずれか一項に記載の方法。
- 前記容器が、前記並進中に、予荷重によって、前記基準面に付勢される、請求項21〜30のいずれか一項に記載の方法。
- 前記検出することが、前記壁の内面に付着している検体を検出することを含む、請求項21〜31のいずれか一項に記載の方法。
- 前記検体が、前記壁の前記内面上の部位のアレイを形成する、請求項32に記載の方法。
- 前記検出装置が、前記部位のアレイから前記検出器に光信号を送信するように構成されているレンズのアレイをさらに備える、請求項33に記載の方法。
- 前記レンズのアレイ内の各レンズが、部位のアレイ内の単一部位を観察するように構成される、請求項34に記載の方法。
- 前記検出することが、cm2あたり少なくとも100部位の密度で存在する前記アレイの部位を分解することを含む、請求項35に記載の方法。
- 前記容器を前記スキャンすることが、前記部位において核酸を配列決定する方法で実施される、請求項36記載の方法。
- 容器をスキャンする方法であって、
(a)容器の第1の部分に予荷重を印加しながら、前記容器内の検体の第1のサブセットを検査することであって、前記予荷重が、前記検体の第1のサブセットを検出ゾーンのxy平面を占めるように位置付け、前記予荷重が、前記容器の第2の部分には印加されない、検査することと、
(b)前記容器を並進させて前記検出ゾーンの前記xy平面に前記検体の第2のサブセットを位置付けることと、
(c)前記容器の第2の部分に前記予荷重を印加しながら、前記容器内の前記検体の前記第2のサブセットを検査することであって、前記予荷重が、前記検体の前記第2のサブセットを前記検出ゾーンの前記xy平面を占めるように位置付け、前記予荷重が、前記容器の前記第1の部分には印加されず、それにより前記容器をスキャンする、検査することと、を含む、方法。 - 前記予荷重が、前記容器を付勢して基準面に接触させるように構成される、請求項38に記載の方法。
- 前記容器が検査されている間、前記基準面が、前記容器の一部分のみに接触する、請求項38〜39のいずれか一項に記載の方法。
- 前記容器が検査されている間、前記予荷重が、加圧ガスに対抗して作用して前記容器を位置付ける、請求項38〜40のいずれか一項に記載の方法。
- 前記容器が検査されている間、前記予荷重が、加圧液体に対抗して作用して前記容器を位置付ける、請求項38〜41のいずれか一項に記載の方法。
- 前記容器が検査されている間、前記予荷重が、磁場に対抗して作用して前記容器を位置付ける、請求項38〜42のいずれか一項に記載の方法。
- 前記容器が検査されている間、前記予荷重が、電場に対抗して作用して前記容器を位置付ける、請求項38〜43のいずれか一項に記載の方法。
- 前記容器が管腔および壁を備え、前記内面が前記管腔に接触する、請求項38〜44のいずれか一項に記載の方法。
- 前記検体の第1のサブセットが、前記容器の前記内面にアレイされている、請求項45に記載の方法。
- 前記検体の第1のサブセットが、前記容器の前記管腔内にある、請求項46に記載の方法。
- 前記検査することが、前記検体によって生成される光学信号を取得することを含む、請求項38〜47のいずれか一項に記載の方法。
- 前記検出装置が、前記容器からカメラに光信号を送信するように構成されている対物レンズをさらに備える、請求項48に記載の方法。
- 前記xy平面に直交する方向で前記対物レンズと前記予荷重との間の相対距離を変更することにより、前記対物レンズの焦点を合わせることをさらに含む、請求項49に記載の方法。
- 前記並進させることが、前記容器上、または前記容器を保持するカートリッジ上の穿孔に回転歯車を接触させることを含む、請求項38〜50のいずれか一項に記載の方法。
- 前記並進させることが、線形アクチュエータと、前記容器上、または前記容器を保持するカートリッジ上の磁性材料または強磁性材料との磁気相互作用を備える、請求項38〜51のいずれか一項に記載の方法。
- 前記容器が、前記並進中に、前記予荷重によって、付勢される、請求項38〜52のいずれか一項に記載の方法。
- 前記容器を前記スキャンすることが、前記核酸を配列決定する方法で実施される、請求項38〜53のいずれか一項に記載の方法。
- 反応装置であって、
(a)管腔および壁を備える容器であって、前記壁が、内面および外面を備え、前記内面が、前記管腔に接触する、容器と、
(b)エネルギー源とともに構造ループを形成する基準面と、
(c)前記容器の前記外面を付勢して前記基準面上の領域に接触させるように構成された予荷重と、
(d)スキャン次元で前記基準面に沿って前記容器をスライドさせるように構成されたスキャンアクチュエータと、
(e)前記容器の前記外面が、前記基準面に接触するように、前記予荷重によって付勢されたときに、前記エネルギー源からのエネルギーを前記内面または前記管腔に方向付けるように構成された送信器と、を備える、反応装置。 - 容器内で反応を行う方法であって、
(a)反応装置の基準面に沿って容器を並進させることであって、前記容器が、管腔および壁を備え、前記管腔が、反応物を備え、前記基準面が、前記並進中に、前記容器のうちの少なくとも一部分に接触し、前記基準面が、エネルギー源とともに構造ループを形成する、並進させることと、
(b)前記エネルギー源から前記容器に沿った異なる場所の前記反応物にエネルギーを方向付けることであって、前記容器が、前記エネルギーを前記反応物に方向付けている間、予荷重によって前記基準面に付勢され、それにより前記容器内で反応を行う、方向付けることと、を含む、方法。 - 容器内で反応を行う方法であって、
(a)容器の第1の部分に予荷重を印加しながら、反応装置から前記容器内の反応物の第1のサブセットにエネルギーを供給することであって、前記予荷重が、前記反応物の第1のサブセットを反応ゾーンのxy平面を占めるように位置付け、前記予荷重が、前記容器の第2の部分には印加されない、供給することと、
(b)前記容器を並進させて前記反応ゾーンの前記xy平面に前記反応物の第2のサブセットを位置付けることと、
(c)前記容器の第2の部分に前記予荷重を印加しながら、前記反応装置から前記容器内の前記検体の前記第2のサブセットにエネルギーを供給することであって、前記予荷重が、前記検体の前記第2のサブセットを前記xy平面を占めるように位置付け、前記予荷重が、前記容器の前記第1の部分には印加されず、それにより前記容器内で反応を行う、供給することと、を含む、方法。
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