JP6539918B2 - 参照電極保持部材及び物質検出装置 - Google Patents
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Description
(1)溶液の電気的基準を定める参照電極を用いて、溶液内の物質を電気化学的に検出する物質検出装置に用いる参照電極保持部材であって、
前記参照電極保持部材は、基材、並びに、該基材に形成された参照電極保持孔、参照電極流路及び第1流路を少なくとも含み、
前記基材には、前記物質検出装置の電気化学センサに面するセンサ対向面が形成され、
前記参照電極保持孔は、前記基材の前記センサ対向面以外の部分に形成され、且つ参照電極を挿入・保持することができ、
前記参照電極流路は、一端が前記基材のセンサ対向面以外の部分で開口部を形成し、他端は前記基材内部に位置し、
前記参照電極保持孔の先端は、前記参照電極流路の端部以外の箇所で前記参照電極流路と連通し、
前記第1流路は、一端が前記基材のセンサ対向面以外の部分で開口部を形成し、他端は前記基材のセンサ対向面で開口部を形成し、
前記参照電極流路の他端と前記第1流路は、前記基材内で連通する、
参照電極保持部材。
(2)一端が前記基材のセンサ対向面以外の部分で開口部を形成し、他端は前記基材のセンサ対向面で開口部を形成する第2流路、
を更に含む、上記(1)に記載の参照電極保持部材。
(3)前記第1流路は少なくとも1以上の分岐流路を含み、
前記第1流路から分岐した分岐流路の端部は、前記センサ対向面で開口部を形成する、
上記(1)又は(2)に記載の参照電極保持部材。
(4)前記第1流路が2以上設けられ、
各々の前記第1流路は、一端が前記基材のセンサ対向面以外の部分で開口部を形成し、他端は前記基材のセンサ対向面で開口部を形成し、且つ、各々の第1流路の内、少なくとも一本は、前記参照電極流路と前記基材内で連通する、
上記(1)又は(2)に記載の参照電極保持部材。
(5)前記センサ対向面に流路が形成されている、
上記(1)〜(4)の何れか一に記載の参照電極保持部材。
(6)参照電極を更に含み、
前記参照電極は導体線であり、前記参照電極保持孔に挿入・保持した時に、前記導体線の少なくとも一部が、前記参照電極流路内に位置する、
上記(1)〜(5)の何れか一に記載の参照電極保持部材。
(7)上記(6)に記載の参照電極保持部材、溶液内の物質を電気化学的に検出する電気化学センサ、及び電圧源、
を少なくとも含む物質検出装置。
(8)参照電極流路及び第1流路に供給する溶液を切り替えるバルブ、
を含む、上記(7)に記載の物質検出装置。
(9)前記電気化学センサが、電位、電流、インピーダンスの少なくとも1以上を検出できる、
上記(7)又は(8)に記載の物質検出装置。
dehydrogenase、Diaphoraseの3酵素が1つのビーズ17A2にアビジン―ビオチン結合を用いて固定され、自己組織化単分子膜17A4として11-FUTを用いている。
Claims (9)
- 溶液の電気的基準を定める参照電極を用いて、溶液内の物質を電気化学的に検出する物質検出装置に用いる参照電極保持部材であって、
前記参照電極保持部材は、基材、並びに、該基材に形成された参照電極保持孔、参照電極流路及び第1流路を少なくとも含み、
前記基材には、前記物質検出装置の電気化学センサに面するセンサ対向面が形成され、
前記参照電極保持孔は、前記基材の前記センサ対向面以外の部分に形成され、且つ参照電極を前記基材の外部から挿入・保持することができ、
前記参照電極流路は、一端が前記基材のセンサ対向面以外の部分で開口部を形成し、他端は前記基材内部に位置し、
前記参照電極保持孔の先端は、前記参照電極流路の端部以外の箇所で前記参照電極流路と連通し、
前記第1流路は、一端が前記基材のセンサ対向面以外の部分で開口部を形成し、他端は前記基材のセンサ対向面で開口部を形成し、
前記参照電極流路の他端と前記第1流路は、前記基材内で連通する、
参照電極保持部材。 - 一端が前記基材のセンサ対向面以外の部分で開口部を形成し、他端は前記基材のセンサ対向面で開口部を形成する第2流路、
を更に含む、請求項1に記載の参照電極保持部材。 - 前記第1流路は少なくとも1以上の分岐流路を含み、
前記第1流路から分岐した分岐流路の端部は、前記センサ対向面で開口部を形成する、
請求項1又は2に記載の参照電極保持部材。 - 前記第1流路が2以上設けられ、
各々の前記第1流路は、一端が前記基材のセンサ対向面以外の部分で開口部を形成し、他端は前記基材のセンサ対向面で開口部を形成し、且つ、各々の第1流路の内、少なくとも一本は、前記参照電極流路と前記基材内で連通する、
請求項1又は2に記載の参照電極保持部材。 - 前記センサ対向面に流路が形成されている、
請求項1〜4の何れか一項に記載の参照電極保持部材。 - 参照電極を更に含み、
前記参照電極は導体線であり、前記参照電極保持孔に挿入・保持した時に、前記導体線の少なくとも一部が、前記参照電極流路内に位置する、
請求項1〜5の何れか一項に記載の参照電極保持部材。 - 請求項6に記載の参照電極保持部材、溶液内の物質を電気化学的に検出する電気化学センサ、及び電圧源、
を少なくとも含む物質検出装置。 - 参照電極流路及び第1流路に供給する溶液を切り替えるバルブ、
を含む、請求項7に記載の物質検出装置。 - 前記電気化学センサが、電位、電流、インピーダンスの少なくとも1以上を検出できる、
請求項7又は8に記載の物質検出装置。
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CN101358945A (zh) * | 2002-07-31 | 2009-02-04 | 株式会社东芝 | 碱基序列检测装置及碱基序列自动解析装置 |
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US8349167B2 (en) * | 2006-12-14 | 2013-01-08 | Life Technologies Corporation | Methods and apparatus for detecting molecular interactions using FET arrays |
EP2092322B1 (en) * | 2006-12-14 | 2016-02-17 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale fet arrays |
JP5420204B2 (ja) * | 2008-07-18 | 2014-02-19 | 株式会社船井電機新応用技術研究所 | 携帯型の物質検出装置 |
US8673627B2 (en) * | 2009-05-29 | 2014-03-18 | Life Technologies Corporation | Apparatus and methods for performing electrochemical reactions |
US9274059B2 (en) * | 2011-03-14 | 2016-03-01 | Battelle Memorial Institute | Microfluidic electrochemical device and process for chemical imaging and electrochemical analysis at the electrode-liquid interface in-situ |
JP2013220066A (ja) * | 2012-04-17 | 2013-10-28 | Hitachi Ltd | センサチップ及びそれを用いた測定方法 |
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2016
- 2016-03-04 WO PCT/JP2016/056849 patent/WO2016143705A1/ja active Application Filing
- 2016-03-04 US US15/556,576 patent/US20180180566A1/en not_active Abandoned
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US20180180566A1 (en) | 2018-06-28 |
JPWO2016143705A1 (ja) | 2017-12-21 |
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