JP2015501844A - 修飾ヌクレオシド、ヌクレオチドおよび核酸組成物 - Google Patents
修飾ヌクレオシド、ヌクレオチドおよび核酸組成物 Download PDFInfo
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- JP2015501844A JP2015501844A JP2014547454A JP2014547454A JP2015501844A JP 2015501844 A JP2015501844 A JP 2015501844A JP 2014547454 A JP2014547454 A JP 2014547454A JP 2014547454 A JP2014547454 A JP 2014547454A JP 2015501844 A JP2015501844 A JP 2015501844A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
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- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
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- A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
- A61K48/0033—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being non-polymeric
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- A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
- A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
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- A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
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- C07K—PEPTIDES
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- C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
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- C12N15/67—General methods for enhancing the expression
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- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12P21/00—Preparation of peptides or proteins
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Cardiology (AREA)
Applications Claiming Priority (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161576705P | 2011-12-16 | 2011-12-16 | |
| US61/576,705 | 2011-12-16 | ||
| US201261618957P | 2012-04-02 | 2012-04-02 | |
| US61/618,957 | 2012-04-02 | ||
| US201261648244P | 2012-05-17 | 2012-05-17 | |
| US61/648,244 | 2012-05-17 | ||
| US201261681712P | 2012-08-10 | 2012-08-10 | |
| US61/681,712 | 2012-08-10 | ||
| US201261696381P | 2012-09-04 | 2012-09-04 | |
| US61/696,381 | 2012-09-04 | ||
| US201261709303P | 2012-10-03 | 2012-10-03 | |
| PCT/US2012/058519 WO2013052523A1 (en) | 2011-10-03 | 2012-10-03 | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
| US61/709,303 | 2012-10-03 | ||
| USPCT/US2012/058519 | 2012-10-03 | ||
| US201261712490P | 2012-10-11 | 2012-10-11 | |
| US61/712,490 | 2012-10-11 | ||
| PCT/US2012/069610 WO2013090648A1 (en) | 2011-12-16 | 2012-12-14 | Modified nucleoside, nucleotide, and nucleic acid compositions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019009835A Division JP2019059793A (ja) | 2011-12-16 | 2019-01-24 | 修飾ヌクレオシド、ヌクレオチドおよび核酸組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015501844A true JP2015501844A (ja) | 2015-01-19 |
| JP2015501844A5 JP2015501844A5 (https=) | 2016-02-04 |
Family
ID=48610363
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014547454A Pending JP2015501844A (ja) | 2011-12-16 | 2012-12-14 | 修飾ヌクレオシド、ヌクレオチドおよび核酸組成物 |
| JP2019009835A Withdrawn JP2019059793A (ja) | 2011-12-16 | 2019-01-24 | 修飾ヌクレオシド、ヌクレオチドおよび核酸組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019009835A Withdrawn JP2019059793A (ja) | 2011-12-16 | 2019-01-24 | 修飾ヌクレオシド、ヌクレオチドおよび核酸組成物 |
Country Status (26)
| Country | Link |
|---|---|
| US (18) | US20130156849A1 (https=) |
| EP (2) | EP4144378A1 (https=) |
| JP (2) | JP2015501844A (https=) |
| KR (1) | KR20140102759A (https=) |
| CN (2) | CN104114572A (https=) |
| AU (3) | AU2012352180A1 (https=) |
| CA (2) | CA3018046A1 (https=) |
| CY (1) | CY1125212T1 (https=) |
| DE (1) | DE12858350T1 (https=) |
| DK (1) | DK2791160T3 (https=) |
| ES (1) | ES2923757T3 (https=) |
| HK (1) | HK1203077A1 (https=) |
| HR (1) | HRP20220717T1 (https=) |
| HU (1) | HUE059110T2 (https=) |
| IL (1) | IL232749A0 (https=) |
| LT (1) | LT2791160T (https=) |
| MX (1) | MX2014007233A (https=) |
| PL (1) | PL2791160T3 (https=) |
| PT (1) | PT2791160T (https=) |
| RS (1) | RS63244B1 (https=) |
| RU (1) | RU2649364C2 (https=) |
| SG (2) | SG10201604896TA (https=) |
| SI (1) | SI2791160T1 (https=) |
| SM (1) | SMT202200355T1 (https=) |
| WO (1) | WO2013090648A1 (https=) |
| ZA (1) | ZA201403783B (https=) |
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017073767A1 (ja) * | 2015-10-30 | 2017-05-04 | 株式会社ボナック | TGF-β1遺伝子の発現を抑制する一本鎖核酸分子を安定に含有する組成物 |
| JP2018529738A (ja) * | 2015-10-05 | 2018-10-11 | モデルナティーエックス, インコーポレイテッド | メッセンジャーリボ核酸薬物の治療投与のための方法 |
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| JP2019514979A (ja) * | 2016-05-09 | 2019-06-06 | アストラゼネカ・アクチエボラーグAstrazeneca Aktiebolag | 親油性抗炎症剤を含む脂質ナノ粒子およびその使用方法 |
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