MX343262B - Administración transdérmica de agentes bioactivos de alta viscosidad. - Google Patents

Administración transdérmica de agentes bioactivos de alta viscosidad.

Info

Publication number
MX343262B
MX343262B MX2014004692A MX2014004692A MX343262B MX 343262 B MX343262 B MX 343262B MX 2014004692 A MX2014004692 A MX 2014004692A MX 2014004692 A MX2014004692 A MX 2014004692A MX 343262 B MX343262 B MX 343262B
Authority
MX
Mexico
Prior art keywords
high viscosity
transdermal delivery
bioactive agents
structures
microneedles
Prior art date
Application number
MX2014004692A
Other languages
English (en)
Other versions
MX2014004692A (es
Inventor
F Ross Russell
Original Assignee
Kimberly Clark Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kimberly Clark Co filed Critical Kimberly Clark Co
Publication of MX2014004692A publication Critical patent/MX2014004692A/es
Publication of MX343262B publication Critical patent/MX343262B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1808—Epidermal growth factor [EGF] urogastrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays or needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0038—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a channel at the side surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061—Methods for using microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Endocrinology (AREA)
  • Medical Informatics (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

Se describe un dispositivo y método para administrar una composición de alta viscosidad. La composición incluye un agente bioactivo para administrar a un sujeto que necesita de este. El método administra el agente bioactivo a una alta biodisponibilidad y con poca pérdida de agente para los mecanismos de defensa naturales del cuerpo. El dispositivo incluye una o más microagujas con estructuras fabricadas en una superficie de las microagujas para formar una nanotopografía. Un patrón aleatorio o no aleatorio de estructuras puede fabricarse tal como un patrón complejo que incluye estructuras de formas y/o tamaños diferentes.
MX2014004692A 2011-10-27 2012-10-16 Administración transdérmica de agentes bioactivos de alta viscosidad. MX343262B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161552069P 2011-10-27 2011-10-27
PCT/IB2012/055621 WO2013061208A1 (en) 2011-10-27 2012-10-16 Transdermal delivery of high viscosity bioactive agents

Publications (2)

Publication Number Publication Date
MX2014004692A MX2014004692A (es) 2014-06-05
MX343262B true MX343262B (es) 2016-10-28

Family

ID=48167198

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014004692A MX343262B (es) 2011-10-27 2012-10-16 Administración transdérmica de agentes bioactivos de alta viscosidad.

Country Status (11)

Country Link
US (4) US9550053B2 (es)
EP (3) EP2771059B1 (es)
JP (1) JP6100271B2 (es)
KR (4) KR102388880B1 (es)
CN (1) CN104039382B (es)
AU (1) AU2012328037B2 (es)
BR (1) BR112014009713A2 (es)
CA (1) CA2853214C (es)
MX (1) MX343262B (es)
RU (1) RU2630610C2 (es)
WO (1) WO2013061208A1 (es)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2563455A4 (en) 2010-04-28 2014-02-19 Kimberly Clark Co METHOD FOR INCREASING THE PERMEABILITY OF AN EPITHELIAL BARRIER
KR20130058012A (ko) 2010-04-28 2013-06-03 킴벌리-클라크 월드와이드, 인크. 사출 성형된 마이크로니들 어레이 및 마이크로니들 어레이의 형성 방법
WO2011135531A2 (en) 2010-04-28 2011-11-03 Kimberly-Clark Worldwide, Inc. MEDICAL DEVICES FOR DELIVERY OF siRNA
MX345837B (es) 2010-04-28 2017-02-16 Kimberly-Clark Worldwide Incorporated Dispositivo para la entrega de un medicamento para la artritis reumatoide.
US8889245B2 (en) * 2010-06-29 2014-11-18 Korea Advanced Institute Of Science And Technology Three-dimensional nanostructures and method for fabricating the same
US12103844B2 (en) 2010-06-29 2024-10-01 Korea Advanced Institute Of Science And Technology Method of fabricating nanostructures using macro pre-patterns
CA2807552A1 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
ES3005233T3 (en) 2010-10-01 2025-03-14 Modernatx Inc Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
JP2014511687A (ja) 2011-03-31 2014-05-19 モデルナ セラピューティクス インコーポレイテッド 工学操作された核酸の送達および製剤
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
EP2763701B1 (en) 2011-10-03 2018-12-19 Moderna Therapeutics, Inc. Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
US20170246439A9 (en) 2011-10-27 2017-08-31 Kimberly-Clark Worldwide, Inc. Increased Bioavailability of Transdermally Delivered Agents
MX343262B (es) * 2011-10-27 2016-10-28 Kimberly Clark Co Administración transdérmica de agentes bioactivos de alta viscosidad.
JP2015501844A (ja) 2011-12-16 2015-01-19 モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 修飾ヌクレオシド、ヌクレオチドおよび核酸組成物
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US9254311B2 (en) 2012-04-02 2016-02-09 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins
WO2013151663A1 (en) 2012-04-02 2013-10-10 modeRNA Therapeutics Modified polynucleotides for the production of membrane proteins
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
ES2921623T3 (es) 2012-11-26 2022-08-30 Modernatx Inc ARN modificado terminalmente
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
BR112015027608A2 (pt) * 2013-05-23 2017-07-25 Kimberly Clark Co microagulhas com geometrias transversais de canal aberto melhoradas
US11185271B2 (en) 2013-09-13 2021-11-30 University Of Utah Research Foundation Methods of making micro-molded electrodes and arrays
WO2015048744A2 (en) 2013-09-30 2015-04-02 Moderna Therapeutics, Inc. Polynucleotides encoding immune modulating polypeptides
KR20160067219A (ko) 2013-10-03 2016-06-13 모더나 세라퓨틱스, 인코포레이티드 저밀도 지단백질 수용체를 암호화하는 폴리뉴클레오타이드
JP6249885B2 (ja) * 2014-05-30 2017-12-20 株式会社ワークス マイクロニードル構造体及びマイクロニードル構造体の製造方法
JP6906885B2 (ja) * 2014-11-14 2021-07-21 ロレアル しわを減少させるためのマイクロニードルシート
PL3325081T3 (pl) 2015-07-24 2021-12-20 Sorrento Therapeutics, Inc. Sposoby dostarczania limfatycznego środków czynnych
CA2991455C (en) 2015-07-24 2023-10-10 Kimberly-Clark Worldwide, Inc. Methods for better delivery of active agents to tumors
CN111343970A (zh) 2017-09-13 2020-06-26 北卡罗莱纳州立大学 微针贴片局部诱导脂肪组织褐变治疗肥胖症
CN109958429B (zh) * 2017-12-21 2021-10-22 中国石油化工股份有限公司 一种判断页岩气吸附气产出的方法
ES2725999A1 (es) * 2018-03-28 2019-10-01 Bsh Electrodomesticos Espana Sa Cuerpo de polimero termoplastico con una estructura superficial, proceso para su fabricacion, y aparato domestico que comprende el cuerpo de polimero termoplastico
US20190313955A1 (en) * 2018-04-13 2019-10-17 Purdue Research Foundation Multiscale microdevices with nanopillars for chronically implanted devices
US11766558B2 (en) 2018-07-30 2023-09-26 Compass Health Brands Corp. Biomedical electrode with anti-microbial properties
WO2020152345A1 (en) * 2019-01-24 2020-07-30 Nil Technology Aps A component for liquid handling with self-cleaning properties
JP6850457B2 (ja) * 2019-03-12 2021-03-31 シンクランド株式会社 角質層採取方法
US12434427B2 (en) 2019-08-20 2025-10-07 Solventum Intellectual Properties Company Microstructured surface with increased microorganism removal when cleaned, articles and methods
US11766822B2 (en) 2019-08-20 2023-09-26 3M Innovative Properties Company Microstructured surface with increased microorganism removal when cleaned, articles and methods
CN115087429A (zh) 2019-11-22 2022-09-20 韦瑞德米克斯公司 用于免疫刺激药物递送的微针贴片
KR20220110273A (ko) 2019-12-05 2022-08-05 소렌토 쎄라퓨틱스, 인코포레이티드 항-pd-1 또는 항-pd-l1 치료제를 림프 전달 장치를 통해 투여하여 암을 치료하는 방법
BR112022022039A2 (pt) 2020-04-28 2022-12-13 Ticona Llc Conjunto de microagulhas
CN111939458A (zh) * 2020-08-25 2020-11-17 四川大学 一种具有超薄柔性背衬层的微针贴片及其制备方法
EP4259415A1 (en) 2020-12-11 2023-10-18 3M Innovative Properties Company Method of thermoforming film with structured surface and articles
CN117813128A (zh) 2021-01-22 2024-04-02 索伦托药业有限公司 用于微升级淋巴递送冠状病毒疫苗的装置
WO2022192594A2 (en) 2021-03-11 2022-09-15 Sorrento Therapeutics, Inc. Nucleic acid molecules and vaccines comprising same for the prevention and treatment of coronavirus infections and disease
CA3221925A1 (en) 2021-06-09 2022-12-15 Sorrento Therapeutics, Inc. Method of treating cancer by administration of an anti-pd-1 or anti-pd-l1 therapeutic agent via a lymphatic microneedle delivery device
JP2024531337A (ja) 2021-08-18 2024-08-29 ソレント・セラピューティクス・インコーポレイテッド リンパ系を標的化する治療剤
WO2023032118A1 (ja) * 2021-09-02 2023-03-09 株式会社北の達人コーポレーション マイクロニードル、マイクロニードルアレイ及びマイクロニードルパッチ並びにマイクロニードルアレイの製造方法
KR102832416B1 (ko) * 2022-01-28 2025-07-10 동국대학교 산학협력단 바이오 의약품의 경피 전달용 용해성 마이크로니들 및 이의 제조 방법
WO2025129128A1 (en) 2023-12-15 2025-06-19 Vivasor, Inc. Compositions and methods for non-viral delivery of therapeutic compounds
JP2025183187A (ja) * 2024-06-04 2025-12-16 花王株式会社 注射キット及び保持具
WO2025254171A1 (ja) * 2024-06-04 2025-12-11 花王株式会社 注射具及び注射キット

Family Cites Families (194)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3797494A (en) 1969-04-01 1974-03-19 Alza Corp Bandage for the administration of drug by controlled metering through microporous materials
US4436741A (en) 1975-12-08 1984-03-13 Alza Corporation Method for administering scopolamine transdermally
US4031894A (en) 1975-12-08 1977-06-28 Alza Corporation Bandage for transdermally administering scopolamine to prevent nausea
US4051840A (en) 1976-01-05 1977-10-04 Sinai Hospital Of Detroit Dynamic aortic patch
US4201211A (en) 1977-07-12 1980-05-06 Alza Corporation Therapeutic system for administering clonidine transdermally
US4379454A (en) 1981-02-17 1983-04-12 Alza Corporation Dosage for coadministering drug and percutaneous absorption enhancer
US4661105A (en) 1981-06-29 1987-04-28 Alza Corporation Medical bandage for administering vasodilator drug
US4725272A (en) 1981-06-29 1988-02-16 Alza Corporation Novel bandage for administering beneficial drug
US5310559A (en) 1982-09-01 1994-05-10 Hercon Laboratories Corporation Device for controlled release and delivery to mammalian tissue of pharmacologically active agents incorporating a rate controlling member which comprises an alkylene-alkyl acrylate copolymer
US4588580B2 (en) 1984-07-23 1999-02-16 Alaz Corp Transdermal administration of fentanyl and device therefor
US4615699A (en) 1985-05-03 1986-10-07 Alza Corporation Transdermal delivery system for delivering nitroglycerin at high transdermal fluxes
US4681584A (en) 1985-05-03 1987-07-21 Alza Corporation Transdermal delivery system for delivering nitroglycerin at high transdermal fluxes
US4698062A (en) 1985-10-30 1987-10-06 Alza Corporation Medical device for pulsatile transdermal delivery of biologically active agents
US4880633A (en) 1986-03-12 1989-11-14 Merck & Co., Inc. Transdermal drug delivery system
US5344656A (en) 1986-09-12 1994-09-06 Alza Corporation Subsaturated transdermal therapeutic system having improved release characteristics
US4908027A (en) 1986-09-12 1990-03-13 Alza Corporation Subsaturated transdermal therapeutic system having improved release characteristics
US4832953A (en) 1987-08-13 1989-05-23 Alza Corporation Method for preventing the formation of a crystalline hydrate in a dispersion of a liquid in a monaqueous matrix
US5004610A (en) 1988-06-14 1991-04-02 Alza Corporation Subsaturated nicotine transdermal therapeutic system
US5364630A (en) 1988-06-14 1994-11-15 Alza Corporation Subsaturated nicotine transdermal therapeutic system
JP3172395B2 (ja) 1995-06-14 2001-06-04 科学技術振興事業団 経皮薬剤放出デバイス
DE19525607A1 (de) 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
US6471993B1 (en) 1997-08-01 2002-10-29 Massachusetts Institute Of Technology Three-dimensional polymer matrices
DK1041975T3 (da) 1997-12-22 2002-11-04 Alza Corp Hastighedskontrollerende membraner til anordninger til kontrolleret indførsel af medikament
GB9805214D0 (en) 1998-03-11 1998-05-06 Univ Glasgow Cell adhesion
AU767122B2 (en) * 1998-06-10 2003-10-30 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
GB9815819D0 (en) 1998-07-22 1998-09-16 Secr Defence Transferring materials into cells and a microneedle array
DE69921489T2 (de) * 1998-08-31 2005-10-27 Johnson & Johnson Consumer Companies, Inc. Elektrotransportvorrichtung mit klingen
US7048723B1 (en) 1998-09-18 2006-05-23 The University Of Utah Research Foundation Surface micromachined microneedles
AU2005200910B2 (en) * 1999-06-04 2006-08-03 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6312612B1 (en) 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US6256533B1 (en) 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6312755B1 (en) 1999-07-16 2001-11-06 Ampc Whey treatment process for achieving high concentration of α-lactalbumin
US6835184B1 (en) 1999-09-24 2004-12-28 Becton, Dickinson And Company Method and device for abrading skin
US6569143B2 (en) 1999-10-14 2003-05-27 Becton, Dickinson And Company Method of intradermally injecting substances
US20020095134A1 (en) 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
ES2248165T3 (es) * 1999-11-15 2006-03-16 Velcro Industries B.V. Elemento de fijacion a la piel.
JP2001238964A (ja) * 2000-02-29 2001-09-04 Japan Lifeline Co Ltd ステント
IL134997A0 (en) 2000-03-09 2001-05-20 Yehoshua Yeshurun Health care system based on micro device
ATE450621T2 (de) 2000-03-30 2009-12-15 Whitehead Biomedical Inst Mediatoren von rns-interferenz, die rns- sequenzspezifisch sind
US7473244B2 (en) 2000-06-02 2009-01-06 The University Of Utah Research Foundation Active needle devices with integrated functionality
US6440096B1 (en) 2000-07-14 2002-08-27 Becton, Dickinson And Co. Microdevice and method of manufacturing a microdevice
US6656147B1 (en) 2000-07-17 2003-12-02 Becton, Dickinson And Company Method and delivery device for the transdermal administration of a substance
WO2002030506A2 (en) * 2000-10-12 2002-04-18 Ink Jet Technology Ltd. Transdermal method
US7828827B2 (en) 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
US7108681B2 (en) 2000-10-16 2006-09-19 Corium International, Inc. Microstructures for delivering a composition cutaneously to skin
US7131987B2 (en) 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
US6979347B1 (en) 2000-10-23 2005-12-27 Advanced Cardiovascular Systems, Inc. Implantable drug delivery prosthesis
NL1016779C2 (nl) 2000-12-02 2002-06-04 Cornelis Johannes Maria V Rijn Matrijs, werkwijze voor het vervaardigen van precisieproducten met behulp van een matrijs, alsmede precisieproducten, in het bijzonder microzeven en membraanfilters, vervaardigd met een dergelijke matrijs.
KR20090049095A (ko) 2000-12-11 2009-05-15 프레지던트 앤드 펠로우즈 오브 하버드 칼리지 나노센서
EP1345646A2 (en) 2000-12-14 2003-09-24 Georgia Tech Research Corporation Microneedle devices and production thereof
US20020111377A1 (en) 2000-12-22 2002-08-15 Albany College Of Pharmacy Transdermal delivery of cannabinoids
US6663820B2 (en) 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
US6591124B2 (en) 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system
US6767341B2 (en) 2001-06-13 2004-07-27 Abbott Laboratories Microneedles for minimally invasive drug delivery
SE0102736D0 (sv) 2001-08-14 2001-08-14 Patrick Griss Side opened out-of-plane microneedles for microfluidic transdermal interfacing and fabrication process of side opened out-of-plane microneedles
US6881203B2 (en) 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
EP1432466B1 (en) 2001-09-12 2012-08-15 Becton, Dickinson and Company Microneedle-based pen device for drug delivery and method for using same
US20040087992A1 (en) 2002-08-09 2004-05-06 Vladimir Gartstein Microstructures for delivering a composition cutaneously to skin using rotatable structures
EP1471953B1 (en) * 2001-09-21 2011-02-16 Valeritas, Inc. Gas pressure actuated microneedle arrays, and systems and methods relating to same
US7429258B2 (en) 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
US6908453B2 (en) 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
JP2005518873A (ja) 2002-03-04 2005-06-30 ナノ パス テクノロジーズ リミテッド 生体障壁を横切る流体輸送の為の装置及び方法
JP4026745B2 (ja) * 2002-03-26 2007-12-26 財団法人大阪産業振興機構 医療用システムおよびその製造方法
US7115108B2 (en) 2002-04-02 2006-10-03 Becton, Dickinson And Company Method and device for intradermally delivering a substance
ES2720098T3 (es) 2002-07-22 2019-07-17 Becton Dickinson Co Dispositivo de infusión similar a un parche
WO2004009978A2 (en) 2002-07-24 2004-01-29 Koch Kenneth W Methods and compositions for on-line gas turbine cleaning
US20040063100A1 (en) 2002-09-30 2004-04-01 Wang Chung Lin Nanoneedle chips and the production thereof
US20040106904A1 (en) 2002-10-07 2004-06-03 Gonnelli Robert R. Microneedle array patch
IL152912A0 (en) * 2002-11-18 2003-06-24 Nanopass Ltd Micro needle systems
US6995336B2 (en) 2003-01-29 2006-02-07 The Regents Of The University Of Michigan Method for forming nanoscale features
WO2005029179A2 (en) 2003-02-13 2005-03-31 The Regents Of The University Of Michigan Combined nanoimprinting and photolithography for micro and nano devices fabrication
US7578954B2 (en) 2003-02-24 2009-08-25 Corium International, Inc. Method for manufacturing microstructures having multiple microelements with through-holes
US7972616B2 (en) 2003-04-17 2011-07-05 Nanosys, Inc. Medical device applications of nanostructured surfaces
AU2004232366A1 (en) 2003-04-21 2004-11-04 Corium International, Inc. Apparatus and methods for repetitive microjet drug delivery
US7803574B2 (en) 2003-05-05 2010-09-28 Nanosys, Inc. Medical device applications of nanostructured surfaces
US7572405B2 (en) 2003-06-02 2009-08-11 Corium International Inc. Method for manufacturing microstructures having hollow microelements using fluidic jets during a molding operation
BRPI0413239B1 (pt) 2003-08-01 2015-11-17 Kanag Baska dispositivo para manutenção de uma via aérea em um paciente
US8097456B2 (en) 2003-08-18 2012-01-17 The Charles Stark Draper Laboratory Nanotopographic compositions and methods for cellular organization in tissue engineered structures
AU2004266161A1 (en) 2003-08-26 2005-03-03 Alza Corporation Device and method for intradermal cell implantation
US20050180952A1 (en) 2003-08-26 2005-08-18 Pettis Ronald J. Methods for intradermal delivery of therapeutics agents
US8016811B2 (en) * 2003-10-24 2011-09-13 Altea Therapeutics Corporation Method for transdermal delivery of permeant substances
DE10353629A1 (de) 2003-11-17 2005-06-16 Lts Lohmann Therapie-Systeme Ag Vorrichtung zur transdermalen Verabreichung von Wirkstoffen
BRPI0416822A (pt) 2003-11-21 2007-03-06 Alza Corp método e sistema de liberação de vacina transdérmica com ultra-som
WO2005060621A2 (en) 2003-11-21 2005-07-07 The Regents Of The University Of California Method and/or apparatus for puncturing a surface for extraction, in situ analysis, and/or substance delivery using microneedles
US20050119723A1 (en) 2003-11-28 2005-06-02 Medlogics Device Corporation Medical device with porous surface containing bioerodable bioactive composites and related methods
US7066992B2 (en) 2003-12-10 2006-06-27 Eastman Kodak Company Solubilized yellow dyes for inks with improved ozone and light stability
GB0402131D0 (en) 2004-01-30 2004-03-03 Isis Innovation Delivery method
JP4832082B2 (ja) 2004-02-03 2011-12-07 久光製薬株式会社 経皮薬物投与装置用インタフェース
US8551391B2 (en) 2004-02-17 2013-10-08 Avery Dennison Corporation Method of making microneedles
US20070191761A1 (en) 2004-02-23 2007-08-16 3M Innovative Properties Company Method of molding for microneedle arrays
US8915957B2 (en) 2004-03-11 2014-12-23 Alcatel Lucent Drug delivery stent
GB0406390D0 (en) 2004-03-22 2004-04-21 Bas Components Ltd Vehicle roofrack mounting
CA2560840C (en) 2004-03-24 2014-05-06 Corium International, Inc. Transdermal delivery device
WO2005112636A2 (en) 2004-05-12 2005-12-01 Kamel Khalili COMPOSITIONS AND METHODS FOR siRNA INHIBITION OF PRIMATE POLYOMAVIRUS GENES
US7315758B2 (en) 2004-06-03 2008-01-01 Lynntech, Inc. Transdermal delivery of therapeutic agent
US20060025848A1 (en) 2004-07-29 2006-02-02 Jan Weber Medical device having a coating layer with structural elements therein and method of making the same
WO2006015299A2 (en) 2004-07-30 2006-02-09 Microchips, Inc. Multi-reservoir device for transdermal drug delivery and sensing
US8696619B2 (en) 2004-08-10 2014-04-15 Robert P. Schnall Drug delivery devices
US20070250018A1 (en) 2004-08-12 2007-10-25 Hirotoshi Adachi Transdermal Drug Administration System with Microneedles
US7316665B2 (en) 2004-08-25 2008-01-08 Becton, Dickinson And Company Method and device for the delivery of a substance including a covering
DE102004041813A1 (de) 2004-08-26 2006-03-02 Siemens Ag Oberfläche mit einer haftungsvermindernden Mikrostruktur und Verfahren zu deren Herstellung
SE0402100D0 (sv) 2004-08-30 2004-08-30 Bonsens Ab Molded micro-needles
US7627938B2 (en) 2004-10-15 2009-12-08 Board Of Regents, The Univeristy Of Texas System Tapered hollow metallic microneedle array assembly and method of making and using the same
US8057842B2 (en) 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
CA2587216C (en) 2004-11-18 2014-11-18 Nanopass Technologies Ltd. System and method for delivering fluid into flexible biological barrier
EP1827564B1 (en) 2004-11-18 2015-07-29 3M Innovative Properties Company Masking method for coating a microneedle array
JP2008522875A (ja) 2004-12-07 2008-07-03 スリーエム イノベイティブ プロパティズ カンパニー マイクロニードルの成形方法
MX2007006742A (es) 2004-12-10 2007-07-25 3M Innovative Properties Co Dispositivo medico.
JPWO2006075689A1 (ja) 2005-01-14 2008-06-12 久光製薬株式会社 医薬物運搬用器具とその製造方法
US20070112548A1 (en) 2005-02-18 2007-05-17 Georgia Tech Research Corporation Methods for fabricating micro-to-nanoscale devices via biologically-induced solid formation on biologically-derived templates, and micro-to-nanoscale structures and micro-to-nanoscale devices made thereby
WO2006128034A1 (en) 2005-05-25 2006-11-30 Georgia Tech Research Corporation Microneedles and methods for microinfusion
US20080195035A1 (en) 2005-06-24 2008-08-14 Frederickson Franklyn L Collapsible Patch and Method of Application
CA2613114C (en) 2005-06-27 2015-02-24 3M Innovative Properties Company Microneedle cartridge assembly and method of applying
WO2007012114A1 (en) 2005-07-25 2007-02-01 Nanotechnology Victoria Pty Ltd Microarray device
US8118753B2 (en) 2005-08-18 2012-02-21 Seoul National University Industry Foundation Barb-wired micro needle made of single crystalline silicon and biopsy method and medicine injecting method using the same
EP2258441A3 (en) 2005-09-02 2011-09-21 Intercell USA, Inc. Devices for transcutaneous delivery of vaccines and transdermal delivery of drugs
US7659252B2 (en) 2005-09-15 2010-02-09 Novomed Technologies, Inc. (Shanghai) Transdermal delivery peptides and method of use thereof
US20070066934A1 (en) 2005-09-19 2007-03-22 Transport Pharmaceuticals, Inc. Electrokinetic delivery system and methods therefor
KR20080066712A (ko) 2005-09-30 2008-07-16 티티아이 엘뷰 가부시키가이샤 관능화된 미세바늘 경피 약물 전달 시스템, 장치 및 방법
EP1928539A1 (en) * 2005-09-30 2008-06-11 Tti Ellebeau, Inc. Functionalized microneedles transdermal drug delivery systems, devices, and methods
US20070112309A1 (en) 2005-11-17 2007-05-17 Jerry Zucker Withdrawal syringe
US20080262416A1 (en) 2005-11-18 2008-10-23 Duan Daniel C Microneedle Arrays and Methods of Preparing Same
EP1962679B1 (en) 2005-12-14 2012-04-11 Silex Microsystems AB Methods for making micro needles and applications thereof
WO2007081876A2 (en) 2006-01-04 2007-07-19 Liquidia Technologies, Inc. Nanostructured surfaces for biomedical/biomaterial applications and processes thereof
US7658728B2 (en) 2006-01-10 2010-02-09 Yuzhakov Vadim V Microneedle array, patch, and applicator for transdermal drug delivery
EP1992386B1 (en) 2006-02-10 2011-11-09 Hisamitsu Pharmaceutical Co., Inc. Transdermal drug administration apparatus having microneedles
US20070224235A1 (en) 2006-03-24 2007-09-27 Barron Tenney Medical devices having nanoporous coatings for controlled therapeutic agent delivery
EP1998844A4 (en) 2006-03-24 2017-03-01 3M Innovative Properties Company Process for making microneedles, microneedle arrays, masters, and replication tools
US20090099502A1 (en) 2006-04-07 2009-04-16 Hisamitsu Pharmaceutical Co., Inc. Microneedle Device And Transdermal Administration Device Provided With Microneedles
CN1830496A (zh) 2006-04-10 2006-09-13 清华大学 “－”字形结构三维微型实心、空心硅针或刀
WO2007124411A1 (en) 2006-04-20 2007-11-01 3M Innovative Properties Company Device for applying a microneedle array
WO2007131050A2 (en) 2006-05-02 2007-11-15 Georgia Tech Research Corporation Method for drug delivery to ocular tissue using microneedle
EP2015803A4 (en) 2006-05-09 2009-05-06 Apogee Technology Inc NANOFIBRE STRUCTURES ON ROUGH SURFACES FOR SEQUESTRATING, ATTACHING AND TRANSFERRING SUBSTANCES
WO2007148240A2 (en) 2006-05-17 2007-12-27 Debiotech S.A. Anisotropic nanoporous coatings for medical implants
US20070276318A1 (en) 2006-05-26 2007-11-29 Mit, Llp Iontosonic-microneedle applicator apparatus and methods
DE102006031506A1 (de) 2006-07-07 2008-01-17 Robert Bosch Gmbh Verfahren zur Herstellung von Mikronadeln in einem Si-Halbleitersubstrat
EP2062611A4 (en) 2006-08-18 2010-01-06 Toppan Printing Co Ltd MICRONADEL AND MICRONADEL
DE102006040642A1 (de) 2006-08-30 2008-03-13 Robert Bosch Gmbh Mikronadeln zur Platzierung in der Haut zwecks transdermaler Applikation von Pharmazeutika
WO2008030557A2 (en) 2006-09-08 2008-03-13 Johns Hopkins University Compositions and methods for enhancing transport through mucus
US20080097352A1 (en) 2006-09-12 2008-04-24 Beck Patricia A Methods of fabricating microneedles with bio-sensory functionality
US20080091226A1 (en) 2006-10-17 2008-04-17 Nanopass Technologies Ltd. Microneedle device
GB0620617D0 (en) 2006-10-17 2006-11-29 Glaxo Group Ltd Novel device
WO2008115290A2 (en) 2006-10-25 2008-09-25 Revalesio Corporation Methods of wound care and treatment
US7785301B2 (en) 2006-11-28 2010-08-31 Vadim V Yuzhakov Tissue conforming microneedle array and patch for transdermal drug delivery or biological fluid collection
US8238995B2 (en) 2006-12-08 2012-08-07 General Electric Company Self-adhering electrodes and methods of making the same
CN102743179B (zh) 2006-12-22 2016-03-16 F·霍夫曼-拉罗氏股份公司 带体内电化学分析物感测的流体传输
US8560059B2 (en) 2007-03-09 2013-10-15 Covidien Lp System and methods for optical sensing and drug delivery using microneedles
ES2558544T3 (es) 2007-03-16 2016-02-05 The Regents Of The University Of California Implantes médicos revestidos en la superficie de nanoestructura y métodos de empleo de los mismos
JP2008237673A (ja) 2007-03-28 2008-10-09 Toppan Printing Co Ltd 針状体およびその製造方法
EP2146689B1 (en) 2007-04-16 2020-08-12 Corium, Inc. Solvent-cast microneedle arrays containing active
US20080311172A1 (en) 2007-04-25 2008-12-18 Schapira Jay N Programmed-release, nanostructured biological construct
US20100196446A1 (en) * 2007-07-10 2010-08-05 Morteza Gharib Drug delivery and substance transfer facilitated by nano-enhanced device having aligned carbon nanotubes protruding from device surface
CA2695731C (en) 2007-08-06 2018-04-03 Transderm, Inc. Microneedle arrays formed from polymer films
US20100121307A1 (en) 2007-08-24 2010-05-13 Microfabrica Inc. Microneedles, Microneedle Arrays, Methods for Making, and Transdermal and/or Intradermal Applications
US20090093879A1 (en) 2007-10-04 2009-04-09 Debra Wawro Micro- and nano-patterned surface features to reduce implant fouling and regulate wound healing
US20090093871A1 (en) 2007-10-08 2009-04-09 Medtronic Vascular, Inc. Medical Implant With Internal Drug Delivery System
US20090099427A1 (en) 2007-10-12 2009-04-16 Arkal Medical, Inc. Microneedle array with diverse needle configurations
WO2009079589A2 (en) 2007-12-17 2009-06-25 New World Pharmaceuticals, Llc Integrated intra-dermal delivery, diagnostic and communication system
WO2009079712A1 (en) 2007-12-24 2009-07-02 The University Of Queensland Coating method
JP2009207733A (ja) 2008-03-05 2009-09-17 Toppan Printing Co Ltd 針状体
EP2100850A1 (en) 2008-03-11 2009-09-16 Stichting Voor De Technische Wetenschappen Microneedle array and a method for manufacturing microneedles
US20090232870A1 (en) 2008-03-13 2009-09-17 Richmond Chemical Corporation Apparatus and method of retaining and releasing molecules from nanostructures by an external stimulus
US20100004733A1 (en) 2008-07-02 2010-01-07 Boston Scientific Scimed, Inc. Implants Including Fractal Structures
CN101347652B (zh) * 2008-09-09 2011-01-12 南京大学 一种空心微针阵列注射器的制备方法
MX349176B (es) 2008-09-22 2017-07-14 Biochemics Inc Suministro transdermico de farmaco empleando un osmolito y un agente vasoactivo.
US20100130958A1 (en) * 2008-11-26 2010-05-27 David Kang Device and Methods for Subcutaneous Delivery of High Viscosity Fluids
KR101039078B1 (ko) 2009-08-04 2011-06-07 (주)마이티시스템 이동되는 약물 저장 캡슐이 있는 미세바늘 약물 전달 시스템
US20110021996A1 (en) 2008-12-18 2011-01-27 Miti Systems Inc. Structure of micro-needle with side channel and manufacturing method thereof
WO2010070628A1 (en) 2008-12-19 2010-06-24 Janisys Limited A fluid transfer device and an active substance cartridge for the fluid transfer device, and a method for controlling the pressure at which an active substance is delivered to a subject from a fluid transfer device
KR101087088B1 (ko) 2008-12-29 2011-11-25 한국과학기술연구원 나노 구조 패턴을 갖는 약물 방출용 스텐트의 제조방법 및 이로부터 제조된 약물 방출용 스텐트
KR101033513B1 (ko) 2009-01-20 2011-05-09 (주)마이티시스템 미세바늘을 이용한 유용성분 피부전달용 용기
EP2396276B1 (en) 2009-02-12 2016-08-31 Trustees Of Tufts College Nanoimprinting of silk fibroin structures for biomedical and biophotonic applications
CN102481440B (zh) 2009-04-23 2014-06-25 新加坡国立大学 包括纳米级突起的装置及其制造方法
EP2424611A4 (en) 2009-05-01 2012-10-24 Nanbu Plastics Co Ltd DEVICE FOR TRANSDERMAL ADMINISTRATIONS
US8389205B2 (en) 2009-06-11 2013-03-05 International Business Machines Corporation Patterning nano-scale patterns on a film comprising unzipping polymer chains
DE102009035795A1 (de) 2009-07-31 2011-02-03 Leibniz-Institut Für Neue Materialien Gemeinnützige Gmbh Struktuierte Oberflächen für Implantate
KR101171888B1 (ko) * 2009-08-27 2012-08-07 중앙대학교 산학협력단 약물 함유 나노입자를 포함하는 마이크로 니들의 제조방법 및 이에 의하여 제조된 마이크로 니들
US20110144591A1 (en) 2009-12-11 2011-06-16 Ross Russell F Transdermal Delivery Device
US20110306853A1 (en) * 2010-03-19 2011-12-15 Michael Darryl Black Body fluid sampling/fluid delivery device
MX345837B (es) 2010-04-28 2017-02-16 Kimberly-Clark Worldwide Incorporated Dispositivo para la entrega de un medicamento para la artritis reumatoide.
KR20130058012A (ko) 2010-04-28 2013-06-03 킴벌리-클라크 월드와이드, 인크. 사출 성형된 마이크로니들 어레이 및 마이크로니들 어레이의 형성 방법
EP2563455A4 (en) 2010-04-28 2014-02-19 Kimberly Clark Co METHOD FOR INCREASING THE PERMEABILITY OF AN EPITHELIAL BARRIER
WO2011135531A2 (en) 2010-04-28 2011-11-03 Kimberly-Clark Worldwide, Inc. MEDICAL DEVICES FOR DELIVERY OF siRNA
WO2012006677A1 (en) 2010-07-14 2012-01-19 The University Of Queensland Patch applying apparatus
EP2632613B1 (en) 2010-10-28 2017-08-30 3M Innovative Properties Company Engineered surfaces for reducing bacterial adhesion
US9017289B2 (en) 2010-11-03 2015-04-28 Covidien Lp Transdermal fluid delivery device
WO2012100002A1 (en) 2011-01-18 2012-07-26 Massachusetts Institute Of Technology Deployable barbed microneedle array and uses thereof
US8696637B2 (en) 2011-02-28 2014-04-15 Kimberly-Clark Worldwide Transdermal patch containing microneedles
MX343262B (es) * 2011-10-27 2016-10-28 Kimberly Clark Co Administración transdérmica de agentes bioactivos de alta viscosidad.
US20170246439A9 (en) 2011-10-27 2017-08-31 Kimberly-Clark Worldwide, Inc. Increased Bioavailability of Transdermally Delivered Agents
JP6535464B2 (ja) 2011-10-27 2019-06-26 ソレント・セラピューティクス・インコーポレイテッド 生理活性薬剤の送達のための移植可能な装置

Also Published As

Publication number Publication date
RU2630610C2 (ru) 2017-09-11
AU2012328037A1 (en) 2014-04-10
US20140343532A1 (en) 2014-11-20
US10213588B2 (en) 2019-02-26
US20190143092A1 (en) 2019-05-16
KR20220051429A (ko) 2022-04-26
US20170128707A1 (en) 2017-05-11
KR102145638B1 (ko) 2020-08-18
US11129975B2 (en) 2021-09-28
BR112014009713A2 (pt) 2017-04-18
US20220008703A1 (en) 2022-01-13
KR102265775B1 (ko) 2021-06-16
RU2014119898A (ru) 2015-12-10
WO2013061208A1 (en) 2013-05-02
JP6100271B2 (ja) 2017-03-22
EP3574950A1 (en) 2019-12-04
KR102388880B1 (ko) 2022-04-22
US9550053B2 (en) 2017-01-24
EP3574950B1 (en) 2021-02-17
EP2771059A1 (en) 2014-09-03
EP3824942A1 (en) 2021-05-26
KR20210073607A (ko) 2021-06-18
AU2012328037B2 (en) 2017-11-02
MX2014004692A (es) 2014-06-05
JP2014530732A (ja) 2014-11-20
EP3824942B1 (en) 2024-01-24
EP2771059A4 (en) 2015-05-06
CA2853214A1 (en) 2013-05-02
CN104039382B (zh) 2018-01-12
KR20140079430A (ko) 2014-06-26
CA2853214C (en) 2020-03-24
KR20200100849A (ko) 2020-08-26
CN104039382A (zh) 2014-09-10
EP2771059B1 (en) 2019-07-17

Similar Documents

Publication Publication Date Title
MX2014004692A (es) Administracion transdermica de agentes bioactivos de alta viscosidad.
EP2563451A4 (en) MEDICAL DEVICES FOR ADMINISTRATION OF siRNA
MX2022009509A (es) Metodo para aumentar la permeabilidad de una barrera epitelial.
MX346337B (es) Dispositivo médico con nanopatrón con interacción celular mejorada.
MX2014004690A (es) Dispositivos implantables para la administracion de agentes bioactivos.
MX345837B (es) Dispositivo para la entrega de un medicamento para la artritis reumatoide.
ECSP13012534A (es) Composición farmacéutica
GB2483505B (en) Devices for transdermal drug delivery
EP4282479A3 (en) Use of pridopidine to treat depression or anxiety
CL2014001070A1 (es) Compuestos derivados de aminoácidos funcionalizados en el n-terminal, capaces de formar micro- o nanopartículas para encapsular un agente; composición; uso para tratar enfermedades; y método de suministro de un polinucleótido a una célula.
MX2013012458A (es) Suministro intravascular de composiciones de nanoparticulas y sus usos.
GB201111485D0 (en) Drug composition and its use in therapy
BR112014013691A2 (pt) pré-formulação, métodos para distribuição de um agente ativo de peptídeo, para a preparação de uma composição cristalina líquida, de tratamento ou profilaxia de um sujeito, processo para a formação de uma pré-formulação, uso de uma mistura cristalina não líquida de baixa viscosidade, dispositivo de administração de pré-preenchido, e, kit
IN2014MN02269A (es)
EP2794879A4 (en) COMPOSITIONS AND METHODS FOR RELEASING BIOLOGICALLY ACTIVE RNA
PH12014502834A1 (en) Pharmaceutical form for extended release of active substances
MY171526A (en) Pharmaceutical formulation for reducing frequency of urination and method of use thereof
WO2015063613A3 (en) Inclusion bodies for transdermal delivery of therapeutic and cosmetic agents
MX2010013790A (es) Composiciones y metodos para tratar inflamacion de corneas.
GEP20196947B (en) Bremelanotide therapy for female sexual dysfunction
MX2016001177A (es) Tratamiento de esclerosis multiple con la combinacion de laquinimod y flupirtina.
MX372892B (es) Metodos y composiciones para el tratamiento de condiciones relacionadas con la falta del suministro de sangre, choque y lesiones neuronales.
WO2014149998A8 (en) Systemic administration of androgen in treating dry eye syndrome
CR20110563A (es) Dispositivos y métodos para suministrar agentes bioactivos
BRPI1104941A8 (pt) Produto nanotecnológico de uma formulação lipossomal elástica para o tratamento da obesidade, lipoma, lipodistrofia e gorduras subcutâneas

Legal Events

Date Code Title Description
FG Grant or registration