BRPI0416822A - método e sistema de liberação de vacina transdérmica com ultra-som - Google Patents

método e sistema de liberação de vacina transdérmica com ultra-som

Info

Publication number
BRPI0416822A
BRPI0416822A BRPI0416822-4A BRPI0416822A BRPI0416822A BR PI0416822 A BRPI0416822 A BR PI0416822A BR PI0416822 A BRPI0416822 A BR PI0416822A BR PI0416822 A BRPI0416822 A BR PI0416822A
Authority
BR
Brazil
Prior art keywords
vaccine
release method
microprojection member
contained
ultrasound
Prior art date
Application number
BRPI0416822-4A
Other languages
English (en)
Inventor
Michel J N Cormier
Weiqi Lin
Georg Widera
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of BRPI0416822A publication Critical patent/BRPI0416822A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205—Vaccinating by means of needles or other puncturing devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/29—Hepatitis virus
    • A61K39/292—Serum hepatitis virus, hepatitis B virus, e.g. Australia antigen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Abstract

"MéTODO E SISTEMA DE LIBERAçãO DE VACINA TRANSDéRMICA COM ULTRA-SOM". Um aparelho e método para transdermicamente liberar uma vacina compreendendo um sistema de liberação tendo (i) um membro de microprojeção (ou sistema) que inclui uma pluralidade de microprojeções (ou arranjo destas) que são adaptadas para perfurar através do stratum corneum na camada de epiderme subjacente, ou camadas de epiderme e de derme e (ii) um dispositivo ultra-sónico. Em uma modalidade, a vacina fica contida em um revestimento biocompatível que é aplicado ao membro de microprojeção. Em uma outra modalidade, o sistema de liberação inclui um pacote de gel tendo uma formulação de hidrogel contendo vacina que fica disposta no membro de microprojeção após aplicação à pele de um paciente. Em uma modalidade alternativa, a vacina fica contida no revestimento e na formulação de hidrogel.
BRPI0416822-4A 2003-11-21 2004-10-21 método e sistema de liberação de vacina transdérmica com ultra-som BRPI0416822A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52406203P 2003-11-21 2003-11-21
PCT/US2004/035015 WO2005051455A2 (en) 2003-11-21 2004-10-21 Ultrasound assisted transdermal vaccine delivery method and system

Publications (1)

Publication Number Publication Date
BRPI0416822A true BRPI0416822A (pt) 2007-03-06

Family

ID=34632860

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0416822-4A BRPI0416822A (pt) 2003-11-21 2004-10-21 método e sistema de liberação de vacina transdérmica com ultra-som

Country Status (12)

Country Link
US (1) US20050112135A1 (pt)
EP (1) EP1686904A4 (pt)
JP (1) JP2007518468A (pt)
KR (1) KR20070011252A (pt)
CN (1) CN1905842A (pt)
AR (1) AR046823A1 (pt)
AU (1) AU2004292953A1 (pt)
BR (1) BRPI0416822A (pt)
CA (1) CA2546723A1 (pt)
MX (1) MXPA06005677A (pt)
TW (1) TW200526287A (pt)
WO (1) WO2005051455A2 (pt)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20120087197A (ko) 2002-07-19 2012-08-06 쓰리엠 이노베이티브 프로퍼티즈 컴파니 마이크로 니들 장치, 마이크로 니들 장치를 사용하는 방법 및 마이크로 니들 장치를 송출하는 방법
WO2005020912A2 (en) 2003-08-25 2005-03-10 3M Innovative Properties Company Delivery of immune response modifier compounds
US20080269163A1 (en) * 2004-10-19 2008-10-30 Sostaric Joe Z Methods and Compositions for Protecting Cells from Ultrasound-Mediated Cytolysis
ATE504328T1 (de) 2004-11-18 2011-04-15 3M Innovative Properties Co Mikronadelanordungsapplikator und halter
WO2006055799A1 (en) 2004-11-18 2006-05-26 3M Innovative Properties Company Masking method for coating a microneedle array
JP5015787B2 (ja) 2004-11-18 2012-08-29 スリーエム イノベイティブ プロパティズ カンパニー マイクロニードルアレイの接触コーティング法
US8057842B2 (en) 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
AU2005314151B2 (en) 2004-12-07 2011-09-08 3M Innovative Properties Company Method of molding a microneedle
JP5301985B2 (ja) 2005-04-07 2013-09-25 スリーエム イノベイティブ プロパティズ カンパニー ツールフィードバック感知のためのシステム及び方法
EP1904158B1 (en) 2005-06-24 2013-07-24 3M Innovative Properties Company Collapsible patch with microneedle array
CA2613111C (en) 2005-06-27 2015-05-26 3M Innovative Properties Company Microneedle array applicator device and method of array application
AU2006261899B2 (en) 2005-06-27 2012-05-10 Kindeva Drug Delivery L.P. Microneedle cartridge assembly and method of applying
US8784336B2 (en) 2005-08-24 2014-07-22 C. R. Bard, Inc. Stylet apparatuses and methods of manufacture
WO2007061964A1 (en) 2005-11-18 2007-05-31 3M Innovative Properties Company Methods for coating microneedles
US7943352B2 (en) * 2006-03-29 2011-05-17 Bacoustics, Llc Apparatus and methods for vaccine development using ultrasound technology
US9119945B2 (en) 2006-04-20 2015-09-01 3M Innovative Properties Company Device for applying a microneedle array
US20070276318A1 (en) * 2006-05-26 2007-11-29 Mit, Llp Iontosonic-microneedle applicator apparatus and methods
DE102006028987A1 (de) * 2006-06-24 2007-12-27 Lts Lohmann Therapie-Systeme Ag Ultraschallverstärktes transdermales therapeutisches System
US8388546B2 (en) 2006-10-23 2013-03-05 Bard Access Systems, Inc. Method of locating the tip of a central venous catheter
US7794407B2 (en) 2006-10-23 2010-09-14 Bard Access Systems, Inc. Method of locating the tip of a central venous catheter
US20150174388A1 (en) 2007-05-07 2015-06-25 Guided Therapy Systems, Llc Methods and Systems for Ultrasound Assisted Delivery of a Medicant to Tissue
WO2016141136A1 (en) * 2015-03-03 2016-09-09 Guided Therapy Systems, Llc Methods and systems for ultrasound assisted delivery of a medicant to tissue
WO2009009064A1 (en) * 2007-07-09 2009-01-15 Orison Corporation Ultrasound coupling material
US9549746B2 (en) * 2007-09-28 2017-01-24 The Queen's University Of Belfast Delivery device and method
US9521961B2 (en) 2007-11-26 2016-12-20 C. R. Bard, Inc. Systems and methods for guiding a medical instrument
US9636031B2 (en) 2007-11-26 2017-05-02 C.R. Bard, Inc. Stylets for use with apparatus for intravascular placement of a catheter
US10751509B2 (en) 2007-11-26 2020-08-25 C. R. Bard, Inc. Iconic representations for guidance of an indwelling medical device
US8781555B2 (en) 2007-11-26 2014-07-15 C. R. Bard, Inc. System for placement of a catheter including a signal-generating stylet
US9649048B2 (en) 2007-11-26 2017-05-16 C. R. Bard, Inc. Systems and methods for breaching a sterile field for intravascular placement of a catheter
US8849382B2 (en) 2007-11-26 2014-09-30 C. R. Bard, Inc. Apparatus and display methods relating to intravascular placement of a catheter
CN101925333B (zh) 2007-11-26 2014-02-12 C·R·巴德股份有限公司 用于脉管系统内的导管放置的集成系统
US10524691B2 (en) 2007-11-26 2020-01-07 C. R. Bard, Inc. Needle assembly including an aligned magnetic element
US10449330B2 (en) 2007-11-26 2019-10-22 C. R. Bard, Inc. Magnetic element-equipped needle assemblies
US8478382B2 (en) 2008-02-11 2013-07-02 C. R. Bard, Inc. Systems and methods for positioning a catheter
US9901714B2 (en) 2008-08-22 2018-02-27 C. R. Bard, Inc. Catheter assembly including ECG sensor and magnetic assemblies
US8437833B2 (en) 2008-10-07 2013-05-07 Bard Access Systems, Inc. Percutaneous magnetic gastrostomy
US9532724B2 (en) 2009-06-12 2017-01-03 Bard Access Systems, Inc. Apparatus and method for catheter navigation using endovascular energy mapping
JP5795576B2 (ja) 2009-06-12 2015-10-14 バード・アクセス・システムズ，インコーポレーテッド 心電図（ｅｃｇ）信号を使用して心臓内またはその近くに血管内デバイスを位置決めするコンピュータベースの医療機器の作動方法
WO2011019760A2 (en) 2009-08-10 2011-02-17 Romedex International Srl Devices and methods for endovascular electrography
US11103213B2 (en) 2009-10-08 2021-08-31 C. R. Bard, Inc. Spacers for use with an ultrasound probe
US10639008B2 (en) 2009-10-08 2020-05-05 C. R. Bard, Inc. Support and cover structures for an ultrasound probe head
EP2531098B1 (en) 2010-02-02 2020-07-15 C.R. Bard, Inc. Apparatus and method for catheter navigation and tip location
MX2012012567A (es) 2010-04-28 2012-11-21 Kimberly Clark Co Metodo para aumentar la permeabilidad de una barrera epitelial.
EP2563451B1 (en) 2010-04-28 2017-11-01 Kimberly-Clark Worldwide, Inc. MEDICAL DEVICES FOR DELIVERY OF siRNA
DK2563450T3 (da) 2010-04-28 2017-11-13 Kimberly Clark Co Apparat til administration af rheumatoid-arthritis-medikament
US9526883B2 (en) 2010-04-28 2016-12-27 Kimberly-Clark Worldwide, Inc. Composite microneedle array including nanostructures thereon
MX2012013858A (es) 2010-05-28 2013-04-08 Bard Inc C R Sistema de guia de insercion para agujas y componentes medicos.
WO2011150376A1 (en) 2010-05-28 2011-12-01 C.R. Bard, Inc. Apparatus for use with needle insertion guidance system
MX338127B (es) 2010-08-20 2016-04-04 Bard Inc C R Reconfirmacion de colocacion de una punta de cateter asistida por ecg.
CN103189009B (zh) 2010-10-29 2016-09-07 C·R·巴德股份有限公司 医疗设备的生物阻抗辅助放置
ES2834200T3 (es) * 2011-02-25 2021-06-16 Hisamitsu Pharmaceutical Co Adyuvante para administración transdérmica o transmucosa y preparación farmacéutica que contiene el mismo
EP2699266B1 (en) 2011-04-21 2019-06-12 Trustees Of Tufts College Compositions and methods for stabilization of active agents
CN102210646B (zh) * 2011-06-07 2013-07-31 辽宁成大生物股份有限公司 一种人用狂犬病疫苗凝胶剂及其制备方法
KR20140051284A (ko) 2011-07-06 2014-04-30 씨. 알. 바드, 인크. 삽입 유도 시스템을 위한 바늘 길이 결정 및 교정
USD724745S1 (en) 2011-08-09 2015-03-17 C. R. Bard, Inc. Cap for an ultrasound probe
USD699359S1 (en) 2011-08-09 2014-02-11 C. R. Bard, Inc. Ultrasound probe head
JP6100271B2 (ja) 2011-10-27 2017-03-22 キンバリー クラーク ワールドワイド インコーポレイテッド 高粘性生理活性薬剤の経皮的送達
US20170246439A9 (en) 2011-10-27 2017-08-31 Kimberly-Clark Worldwide, Inc. Increased Bioavailability of Transdermally Delivered Agents
WO2013070775A1 (en) 2011-11-07 2013-05-16 C.R. Bard, Inc Ruggedized ultrasound hydrogel insert
EP2785406A4 (en) 2011-11-30 2015-10-21 3M Innovative Properties Co MICRO NEEDLE DEVICE COMPRISING A PEPTIDE THERAPEUTIC AGENT AND AN AMINO ACID AND METHODS OF MAKING AND USING THE SAME
EP2859910B1 (en) * 2012-06-12 2020-03-25 Hisamitsu Pharmaceutical Co., Inc. Microneedle sheet
CN104837413B (zh) 2012-06-15 2018-09-11 C·R·巴德股份有限公司 检测超声探测器上可移除帽的装置及方法
US11510983B2 (en) * 2013-03-15 2022-11-29 The General Hospital Corporation Method and apparatus for boosting vaccine efficacy
KR101751653B1 (ko) 2013-06-18 2017-06-27 히사미쓰 세이야꾸 가부시키가이샤 어플리케이터
ES2753423T3 (es) 2013-06-19 2020-04-08 Hisamitsu Pharmaceutical Co Aplicador
WO2015064710A1 (ja) 2013-10-31 2015-05-07 久光製薬株式会社 アジュバント組成物、これを含むアジュバント製剤、及びキット
ES2811323T3 (es) 2014-02-06 2021-03-11 Bard Inc C R Sistemas para el guiado y la colocación de un dispositivo intravascular
JP2017537690A (ja) * 2014-11-12 2017-12-21 ミューファーマ ピーティーワイ リミテッド 非侵襲性の薬剤塗布具
US10589077B2 (en) 2014-12-05 2020-03-17 Hisamitsu Pharmaceutical Co., Inc. Microneedle device system
US10973584B2 (en) 2015-01-19 2021-04-13 Bard Access Systems, Inc. Device and method for vascular access
SG11201708861VA (en) 2015-04-29 2017-11-29 Radius Pharmaceuticals Inc Methods for treating cancer
WO2016210325A1 (en) 2015-06-26 2016-12-29 C.R. Bard, Inc. Connector interface for ecg-based catheter positioning system
WO2017021546A1 (en) * 2015-08-05 2017-02-09 Curevac Ag Epidermal mrna vaccine
US11000207B2 (en) 2016-01-29 2021-05-11 C. R. Bard, Inc. Multiple coil system for tracking a medical device
RU2762607C2 (ru) 2016-09-13 2021-12-21 Аллерган, Инк. Стабилизированные небелковые композиции клостридиального токсина
WO2018053524A1 (en) 2016-09-19 2018-03-22 Vaxess Technologies, Inc. Vaccine formulations with increased stability
US10385008B2 (en) 2017-01-05 2019-08-20 Radius Pharmaceuticals, Inc. Polymorphic forms of RAD1901-2HCL
US11643385B2 (en) 2018-07-04 2023-05-09 Radius Pharmaceuticals, Inc. Polymorphic forms of RAD1901-2HCl
US10992079B2 (en) 2018-10-16 2021-04-27 Bard Access Systems, Inc. Safety-equipped connection systems and methods thereof for establishing electrical connections
CN115156018A (zh) * 2022-08-02 2022-10-11 广东云声科技有限公司 3d打印制备的个性化多功能超声阵列装置及制备方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3136314A (en) * 1960-08-01 1964-06-09 Kravitz Harvey Vaccinating devices
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
BE795384A (fr) * 1972-02-14 1973-08-13 Ici Ltd Pansements
OA05448A (fr) * 1975-10-16 1981-03-31 Manufrance Manufacture Francai Dispositif vaccinateur multipénétrant.
FR2474856A1 (fr) * 1980-01-31 1981-08-07 Merieux Inst Dispositif scarificateur
EP0429842B1 (en) * 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
US5487726A (en) * 1994-06-16 1996-01-30 Ryder International Corporation Vaccine applicator system
AU5740496A (en) * 1995-05-22 1996-12-11 General Hospital Corporation, The Micromechanical device and method for enhancing delivery of compounds through the skin
ATE234129T1 (de) * 1996-06-18 2003-03-15 Alza Corp Vorrichtung zur verbesserung der transdermalen verabreichung von medikamenten oder der abnahme von körperflüssigkeiten
US6234990B1 (en) * 1996-06-28 2001-05-22 Sontra Medical, Inc. Ultrasound enhancement of transdermal transport
US6183434B1 (en) * 1996-07-03 2001-02-06 Spectrx, Inc. Multiple mechanical microporation of skin or mucosa
US5916524A (en) * 1997-07-23 1999-06-29 Bio-Dot, Inc. Dispensing apparatus having improved dynamic range
US5738728A (en) * 1996-07-26 1998-04-14 Bio Dot, Inc. Precision metered aerosol dispensing apparatus
US5743960A (en) * 1996-07-26 1998-04-28 Bio-Dot, Inc. Precision metered solenoid valve dispenser
US5741554A (en) * 1996-07-26 1998-04-21 Bio Dot, Inc. Method of dispensing a liquid reagent
DK1037686T3 (da) * 1997-12-11 2006-01-02 Alza Corp Apparat til forögelse af transdermal gennemströmning af midler
ATE221400T1 (de) * 1997-12-11 2002-08-15 Alza Corp Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses
US6190315B1 (en) * 1998-01-08 2001-02-20 Sontra Medical, Inc. Sonophoretic enhanced transdermal transport
US6091975A (en) * 1998-04-01 2000-07-18 Alza Corporation Minimally invasive detecting device
AU767122B2 (en) * 1998-06-10 2003-10-30 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
US6620123B1 (en) * 1999-12-17 2003-09-16 Sontra Medical, Inc. Method and apparatus for producing homogenous cavitation to enhance transdermal transport
EP1341452B1 (en) * 2000-10-13 2008-12-10 Alza Corporation Microprotrusion member retainer for impact applicator
US20020099356A1 (en) * 2001-01-19 2002-07-25 Unger Evan C. Transmembrane transport apparatus and method
CA2543280A1 (en) * 2003-10-28 2005-05-19 Alza Corporation Delivery of polymer conjugates of therapeutic peptides and proteins via coated microporjections

Also Published As

Publication number Publication date
AU2004292953A1 (en) 2005-06-09
TW200526287A (en) 2005-08-16
EP1686904A2 (en) 2006-08-09
JP2007518468A (ja) 2007-07-12
WO2005051455A2 (en) 2005-06-09
WO2005051455A3 (en) 2006-04-13
MXPA06005677A (es) 2006-12-14
US20050112135A1 (en) 2005-05-26
AR046823A1 (es) 2005-12-28
CN1905842A (zh) 2007-01-31
EP1686904A4 (en) 2008-02-27
KR20070011252A (ko) 2007-01-24
CA2546723A1 (en) 2005-06-09

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