MX346337B - Dispositivo médico con nanopatrón con interacción celular mejorada. - Google Patents

Dispositivo médico con nanopatrón con interacción celular mejorada.

Info

Publication number
MX346337B
MX346337B MX2012012563A MX2012012563A MX346337B MX 346337 B MX346337 B MX 346337B MX 2012012563 A MX2012012563 A MX 2012012563A MX 2012012563 A MX2012012563 A MX 2012012563A MX 346337 B MX346337 B MX 346337B
Authority
MX
Mexico
Prior art keywords
nanotopography
fabricated
nanopatterned
medical device
devices
Prior art date
Application number
MX2012012563A
Other languages
English (en)
Other versions
MX2012012563A (es
Inventor
Frederick Ross * Russell
Original Assignee
Kimberly Clark Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kimberly Clark Co filed Critical Kimberly Clark Co
Publication of MX2012012563A publication Critical patent/MX2012012563A/es
Publication of MX346337B publication Critical patent/MX346337B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/20—Surgical instruments, devices or methods for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205—Vaccinating by means of needles or other puncturing devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays or needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C59/00—Surface shaping of articles, e.g. embossing; Apparatus therefor
    • B29C59/002—Component parts, details or accessories; Auxiliary operations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C59/00—Surface shaping of articles, e.g. embossing; Apparatus therefor
    • B29C59/02—Surface shaping of articles, e.g. embossing; Apparatus therefor by mechanical means, e.g. pressing
    • B29C59/026—Surface shaping of articles, e.g. embossing; Apparatus therefor by mechanical means, e.g. pressing of layered or coated substantially flat surfaces
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0038—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a channel at the side surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061—Methods for using microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C59/00—Surface shaping of articles, e.g. embossing; Apparatus therefor
    • B29C59/02—Surface shaping of articles, e.g. embossing; Apparatus therefor by mechanical means, e.g. pressing
    • B29C59/022—Surface shaping of articles, e.g. embossing; Apparatus therefor by mechanical means, e.g. pressing characterised by the disposition or the configuration, e.g. dimensions, of the embossments or the shaping tools therefor
    • B29C2059/023—Microembossing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2995/00—Properties of moulding materials, reinforcements, fillers, preformed parts or moulds
    • B29K2995/0037—Other properties
    • B29K2995/0056—Biocompatible, e.g. biopolymers or bioelastomers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/753—Medical equipment; Accessories therefor
    • B29L2031/7544—Injection needles, syringes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/756—Microarticles, nanoarticles
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
    • Y10T156/10—Methods of surface bonding and/or assembly therefor
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
    • Y10T156/10—Methods of surface bonding and/or assembly therefor
    • Y10T156/1002—Methods of surface bonding and/or assembly therefor with permanent bending or reshaping or surface deformation of self sustaining lamina
    • Y10T156/1039—Surface deformation only of sandwich or lamina [e.g., embossed panels]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
    • Y10T156/10—Methods of surface bonding and/or assembly therefor
    • Y10T156/1052—Methods of surface bonding and/or assembly therefor with cutting, punching, tearing or severing
    • Y10T156/1056—Perforating lamina
    • Y10T156/1057—Subsequent to assembly of laminae

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Mechanical Engineering (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Micromachines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Injection Moulding Of Plastics Or The Like (AREA)
  • Moulds For Moulding Plastics Or The Like (AREA)

Abstract

Están descritos los dispositivos y métodos a base de nanotopografía para interactuar con un componente de un tejido conector dérmico. Los dispositivos incluyen estructuras fabricadas sobre una superficie para formar una nanotopografía. Un patrón al azar o no al azar de las estructuras puede ser fabricado tal como un patrón complejo incluyendo estructuras de diferentes tamaños y/o de diferentes formas. Las microagujas pueden ser benéficamente utilizadas para la entrega de un agente a una célula o tejido. Los dispositivos pueden ser utilizados para alterar directamente o indirectamente el comportamiento de célula a través de la interacción de una nanotopografía fabricada con la membrana de plasma de una célula y/o con un componente de matriz extracelular.
MX2012012563A 2010-04-28 2011-04-27 Dispositivo médico con nanopatrón con interacción celular mejorada. MX346337B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US32872310P 2010-04-28 2010-04-28
US41107110P 2010-11-08 2010-11-08
US201161435939P 2011-01-25 2011-01-25
PCT/IB2011/051865 WO2011135533A2 (en) 2010-04-28 2011-04-27 Nanopatterned medical device with enhanced cellular interaction

Publications (2)

Publication Number Publication Date
MX2012012563A MX2012012563A (es) 2012-11-23
MX346337B true MX346337B (es) 2017-03-14

Family

ID=44858839

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2012012317A MX2012012317A (es) 2010-04-28 2011-04-27 Arreglo de microagujas moldeado por inyeccion y metodo para formar el arreglo de microagujas.
MX2012012566A MX343238B (es) 2010-04-28 2011-04-27 Arreglo de microaguja compuesto incluyendo nanoestructuras sobre el mismo.
MX2012012563A MX346337B (es) 2010-04-28 2011-04-27 Dispositivo médico con nanopatrón con interacción celular mejorada.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
MX2012012317A MX2012012317A (es) 2010-04-28 2011-04-27 Arreglo de microagujas moldeado por inyeccion y metodo para formar el arreglo de microagujas.
MX2012012566A MX343238B (es) 2010-04-28 2011-04-27 Arreglo de microaguja compuesto incluyendo nanoestructuras sobre el mismo.

Country Status (14)

Country Link
US (8) US10245421B2 (es)
EP (2) EP2563452B1 (es)
JP (4) JP5868953B2 (es)
KR (3) KR101794377B1 (es)
CN (3) CN102958556B (es)
AU (3) AU2011288209C1 (es)
BR (1) BR112012027672A2 (es)
CA (3) CA2796198C (es)
DK (1) DK2563453T3 (es)
ES (2) ES2726451T3 (es)
MX (3) MX2012012317A (es)
PT (1) PT2563453T (es)
RU (1) RU2570280C2 (es)
WO (3) WO2011135532A2 (es)

Families Citing this family (143)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006304229A1 (en) 2005-10-13 2007-04-26 Synthes Gmbh Drug-impregnated encasement
US8834423B2 (en) 2009-10-23 2014-09-16 University of Pittsburgh—of the Commonwealth System of Higher Education Dissolvable microneedle arrays for transdermal delivery to human skin
US20110144591A1 (en) * 2009-12-11 2011-06-16 Ross Russell F Transdermal Delivery Device
RU2570280C2 (ru) 2010-04-28 2015-12-10 Кимберли-Кларк Ворлдвайд, Инк. Композитная матрица микроигл, содержащая на поверхности наноструктуры
WO2012046149A1 (en) 2010-04-28 2012-04-12 Kimberly-Clark Worldwide, Inc. Method for increasing permeability of an epithelial barrier
US9522262B2 (en) * 2010-04-28 2016-12-20 Kimberly-Clark Worldwide, Inc. Medical devices for delivery of siRNA
PT2563450T (pt) 2010-04-28 2017-08-28 Kimberly Clark Co Dispositivo para entrega de medicação para a artrite reumatóide
DE102010030864A1 (de) * 2010-07-02 2012-01-05 Robert Bosch Gmbh Herstellungsverfahren für eine Mikronadelanordnung und entsprechende Mikronadelanordnung und Verwendung
MX2013004660A (es) * 2010-10-25 2013-10-28 Teijin Ltd Microaguja.
CA2827158A1 (en) * 2011-01-18 2012-07-26 Massachusetts Institute Of Technology Device and uses thereof
US8696637B2 (en) 2011-02-28 2014-04-15 Kimberly-Clark Worldwide Transdermal patch containing microneedles
WO2012167162A2 (en) * 2011-06-03 2012-12-06 University Of Washington Methods for the production of chitin nanofibers and uses thereof
US8636696B2 (en) 2011-06-10 2014-01-28 Kimberly-Clark Worldwide, Inc. Transdermal device containing microneedles
PL3542851T3 (pl) 2011-10-27 2022-04-25 Sorrento Therapeutics, Inc. Wszczepialne urządzenia do dostarczania środków biologicznie czynnych
CN104039382B (zh) 2011-10-27 2018-01-12 金伯利-克拉克环球有限公司 高粘度生物活性剂的经皮递送
US20170246439A9 (en) 2011-10-27 2017-08-31 Kimberly-Clark Worldwide, Inc. Increased Bioavailability of Transdermally Delivered Agents
TWI590843B (zh) 2011-12-28 2017-07-11 信迪思有限公司 膜及其製造方法
US20130216779A1 (en) * 2012-02-16 2013-08-22 University Of Tennessee Research Foundation Nanostructures from Laser-Ablated Nanohole Templates
US20150064141A1 (en) 2012-04-05 2015-03-05 The Regents Of The University Of California Regenerative sera cells and mesenchymal stem cells
US9334571B2 (en) * 2012-06-29 2016-05-10 Regents Of The University Of Minnesota Method of forming individual metallic microstructures
US9249014B2 (en) * 2012-11-06 2016-02-02 Infineon Technologies Austria Ag Packaged nano-structured component and method of making a packaged nano-structured component
US9320534B2 (en) 2012-12-13 2016-04-26 Alcon Research, Ltd. Fine membrane forceps with integral scraping feature
KR102378235B1 (ko) * 2012-12-14 2022-03-25 민데라 코포레이션 바이오마커의 검출 및 취득을 위한 방법 및 디바이스
CN104321034B (zh) * 2013-01-11 2018-01-30 Bvw控股公司 可植入的超疏水表面
WO2014132239A1 (en) * 2013-02-28 2014-09-04 Kimberly-Clark Worldwide, Inc. Drug delivery device
KR101821572B1 (ko) * 2013-06-17 2018-01-26 주식회사 주빅 무고통 및 무패치의 슈팅 마이크로구조체
CA2916249C (en) * 2013-06-21 2021-07-13 DePuy Synthes Products, Inc. Films and methods of manufacture
US10390724B2 (en) * 2013-06-26 2019-08-27 The Penn State Research Foundation Three-dimensional bio-medical probe sensing and contacting structures with addressibility and tunability
GB201312669D0 (en) * 2013-07-16 2013-08-28 Univ Swansea Microneedles and method of manufacture
EP3024530A4 (en) * 2013-07-22 2017-04-19 Tuo Jin Fabrication process of phase-transition microneedle patch
US11185271B2 (en) 2013-09-13 2021-11-30 University Of Utah Research Foundation Methods of making micro-molded electrodes and arrays
CN103558367B (zh) * 2013-11-19 2014-07-30 长春理工大学 生理条件下用纳米电极阵列测量生物细胞电特性的系统及方法
CA2935964A1 (en) * 2014-01-10 2015-07-16 Sebacia, Inc. Sub-surface array of absorber materials, and light irradiation therapy
US10973682B2 (en) 2014-02-24 2021-04-13 Alcon Inc. Surgical instrument with adhesion optimized edge condition
US20160279401A1 (en) 2015-03-27 2016-09-29 Allergan, Inc. Dissolvable microneedles for skin treatment
EP3122332B1 (en) * 2014-03-28 2020-05-27 Allergan, Inc. Dissolvable microneedles for skin treatment
RU2719937C1 (ru) * 2014-04-24 2020-04-23 Джорджия Тек Рисёч Корпорейшн Микроиглы и способы их изготовления
CA2945007C (en) 2014-04-30 2017-08-29 Kimberly-Clark Worldwide, Inc. Cartridge portion of transdermal drug delivery apparatus and methods
US10232160B2 (en) 2014-04-30 2019-03-19 Sorrento Therapeutics, Inc. Transdermal drug delivery apparatus and methods
JP6298541B2 (ja) 2014-04-30 2018-03-20 キンバリー クラーク ワールドワイド インコーポレイテッド 経皮的薬物送達装置のコントローラ部分および方法
KR101724251B1 (ko) * 2014-04-30 2017-04-06 킴벌리-클라크 월드와이드, 인크. 도포식 현미침 조립체
JP5931130B2 (ja) * 2014-06-20 2016-06-08 三島光産株式会社 マイクロニードルアレイの製造方法及びこれに用いる射出成形用金型
US9933387B1 (en) 2014-09-07 2018-04-03 Biolinq, Inc. Miniaturized sub-nanoampere sensitivity low-noise potentiostat system
CN104586409A (zh) * 2015-01-13 2015-05-06 江苏磐宇科技有限公司 安全采血针生产加工工艺
WO2016126253A1 (en) 2015-02-05 2016-08-11 The Penn State Research Foundation Nano-pore arrays for bio-medical, environmental, and industrial sorting, filtering, monitoring, or dispensing
JP6395739B2 (ja) * 2015-03-10 2018-09-26 富士フイルム株式会社 測定方法及び測定装置
WO2016149673A1 (en) 2015-03-18 2016-09-22 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Bioactive components conjugated to substrates of microneedle arrays
JP5852280B1 (ja) * 2015-03-23 2016-02-03 コスメディ製薬株式会社 マイクロニードルおよびその製造
CN105036052B (zh) * 2015-06-04 2017-01-18 清华大学 一种带取向性结构的微针尖及其连续输运液体的方法
DK3325080T3 (da) 2015-07-24 2021-10-04 Sorrento Therapeutics Inc Fremgangsmåder til bedre indgivelse af aktive midler til tumorer
JP6929829B2 (ja) * 2015-07-24 2021-09-01 ソレント・セラピューティクス・インコーポレイテッド 薬剤送達装置
KR101688739B1 (ko) * 2015-07-30 2016-12-23 연세대학교 산학협력단 침습형 생체소자 제조방법 및 그 생체소자
EP3331603A4 (en) * 2015-08-06 2019-01-23 The Regents of The University of California METHOD FOR PRODUCING AN ELECTRODE ARRANGEMENT FOR TRANSCUTANEOUS ELECTRICAL STIMULATION OF THE BACKMARK
US11684763B2 (en) 2015-10-16 2023-06-27 University of Pittsburgh—of the Commonwealth System of Higher Education Multi-component bio-active drug delivery and controlled release to the skin by microneedle array devices
KR101638865B1 (ko) 2015-10-21 2016-07-12 한국과학기술원 음각 형태의 니들 형상 몰드의 제조방법
WO2017120322A1 (en) 2016-01-05 2017-07-13 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Skin microenvironment targeted delivery for promoting immune and other responses
US20170191912A1 (en) * 2016-01-06 2017-07-06 International Business Machines Corporation Semiconductor manufactured nano-structures for microbe or virus trapping or destruction
KR101747099B1 (ko) * 2016-02-11 2017-06-14 권영덕 생체적합성 고분자를 이용한 마이크로니들의 제조방법
KR101956444B1 (ko) * 2016-03-07 2019-03-08 성균관대학교산학협력단 자가 조립 나노입자 방출형 용해성 마이크로니들 구조체 및 그 제조방법
EP3377226B1 (en) * 2016-03-28 2021-02-17 Illumina, Inc. Multi-plane microarrays
KR101719319B1 (ko) * 2016-04-05 2017-03-23 주식회사 엘지생활건강 효율적인 피부 천공을 위한 마이크로니들 구조
CN109475726B (zh) 2016-04-29 2021-05-18 索伦托治疗有限公司 微针阵列组件、药物递送装置和用于大面积低压输注液体的方法
US10092207B1 (en) 2016-05-15 2018-10-09 Biolinq, Inc. Tissue-penetrating electrochemical sensor featuring a co-electrodeposited thin film comprised of polymer and bio-recognition element
CN107569238A (zh) * 2016-07-04 2018-01-12 中山大学 一种粘贴式烟囱型微针阵列及其制造方法
CN116726371A (zh) * 2016-08-03 2023-09-12 沃达瑞公司 微阵列和方法
TW201815356A (zh) 2016-10-18 2018-05-01 諾華公司 具有表面紋理的外科手術器械
US12415058B2 (en) 2016-12-22 2025-09-16 Ohio State Innovation Foundation Interpenetrating microstructures for nanochannel-based sampling and/or cargo delivery
BR112019012924A2 (pt) * 2016-12-22 2019-12-10 Ohio State Innovation Foundation microestruturas interpenetrantes para liberação de carga com base em nanocanal
EP4039250A1 (en) * 2016-12-28 2022-08-10 Chugai Seiyaku Kabushiki Kaisha Self-emulsifying drug formulation for improving membrane permeability of compound
JP2020507422A (ja) 2017-02-17 2020-03-12 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ 活性成分を含むマイクロニードルアレイ
US12109032B1 (en) 2017-03-11 2024-10-08 Biolinq Incorporated Methods for achieving an isolated electrical interface between an anterior surface of a microneedle structure and a posterior surface of a support structure
WO2018170132A1 (en) 2017-03-14 2018-09-20 University Of Connecticut Biodegradable pressure sensor
US11045142B1 (en) 2017-04-29 2021-06-29 Biolinq, Inc. Heterogeneous integration of silicon-fabricated solid microneedle sensors and CMOS circuitry
IT201700048421A1 (it) * 2017-05-04 2018-11-04 Materias S R L Dispositivo per la somministrazione transdermica di molecole attive, usi di tale dispositivo e metodi di produzione di tale dispositivo e di relativi componenti
KR102033686B1 (ko) 2017-05-19 2019-10-18 보령제약 주식회사 도네페질을 함유하는 마이크로니들 경피 패치
WO2019055594A1 (en) * 2017-09-13 2019-03-21 North Carolina State University BRUSHING ADIPOSE TISSUE INDUCED LOCALLY BY MICRO-NEEDLE STAMPS FOR THE TREATMENT OF OBESITY
RU2677491C1 (ru) * 2017-10-06 2019-01-17 Общество с ограниченной ответственностью "Игла" Способ изготовления микроигл и массива микроигл
US20200388462A1 (en) * 2017-12-05 2020-12-10 Asml Netherlands B.V. Systems and methods for tuning and calibrating charged particle beam apparatus
CN111433001B (zh) * 2017-12-05 2022-03-18 古河电气工业株式会社 功能性构件及其制造方法
US20190185683A1 (en) * 2017-12-20 2019-06-20 Industry-Academic Cooperation Foundation, Yonsei University Structure for preventing adhesion of microorganisms and method of manufacturing the same
KR102078447B1 (ko) 2018-01-11 2020-02-17 부산대학교 산학협력단 티타늄 나노튜브를 포함하는 마이크로니들 패치 및 이의 제조방법
CN110115707B (zh) * 2018-02-07 2021-01-19 华中科技大学 一种基于相分离技术制备多孔聚合物微针的方法及其应用
US11926091B2 (en) 2018-03-27 2024-03-12 UNITED STATES OF AMERICA has certain rights in the invention from DOE Grant No. DE-SC0008581 In situ partially degradable separation interface for fabrication of complex near net shape objects by pressure assisted sintering
KR102146704B1 (ko) 2018-04-13 2020-08-21 가천대학교 산학협력단 사이클로스포린 A (CsA) 경피 및 피내 약물전달용 마이크로구조체
CN108836354A (zh) * 2018-04-24 2018-11-20 中山大学 一种微针阵列生物传感器的制备方法
TWI666166B (zh) * 2018-05-11 2019-07-21 中原大學 用於排列膠體粒子的裝置
US11850416B2 (en) * 2018-06-22 2023-12-26 The Regents Of The University Of Michigan Method of manufacturing a probe array
CN109078260B (zh) * 2018-07-02 2020-06-30 华中科技大学 一种制备中空微针阵列的方法
CN108939283B (zh) * 2018-07-16 2021-04-23 清华大学深圳研究生院 一种人体安全可降解的微针阵列及其制造方法和模具
WO2020023804A1 (en) * 2018-07-25 2020-01-30 Microdermics Inc. Microneedles, apparatus comprising microneedles and methods for using same
CN110834405A (zh) * 2018-08-17 2020-02-25 伊森医药科技(上海)有限公司 一种塑料注射针的制作工艺及其产品
WO2020041694A1 (en) * 2018-08-24 2020-02-27 North Carolina State University Stem cell microneedle patch for treating heart diseases
KR102039582B1 (ko) * 2018-12-12 2019-11-01 주식회사 라파스 인장 공정으로 제조하기에 적합한 마이크로니들 재료의 적합성 시험 방법 및 이를 포함하는 마이크로니들 제조 방법
CN109529186B (zh) * 2018-12-17 2021-05-11 广东工业大学 一种药物涂层非晶合金微针及其制作方法
US11826495B2 (en) 2019-03-01 2023-11-28 University Of Connecticut Biodegradable piezoelectric ultrasonic transducer system
EP3718463A1 (en) 2019-04-02 2020-10-07 Ambu A/S A housing for the tip of a disposable insertion endoscope
CA3138521A1 (en) 2019-05-16 2020-11-19 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Microneedle arrays with undercut features for cutaneous and non-cutaneous drug delivery
KR102149338B1 (ko) 2019-08-02 2020-08-28 안형수 육각형 실리콘 결정 성장 장치 및 방법
US12434427B2 (en) 2019-08-20 2025-10-07 Solventum Intellectual Properties Company Microstructured surface with increased microorganism removal when cleaned, articles and methods
US11766822B2 (en) 2019-08-20 2023-09-26 3M Innovative Properties Company Microstructured surface with increased microorganism removal when cleaned, articles and methods
DE102019122648B4 (de) * 2019-08-22 2021-04-29 Lts Lohmann Therapie-Systeme Ag Vorrichtung und Verfahren zur Herstellung von Mikrostrukturen
WO2021050404A1 (en) * 2019-09-10 2021-03-18 The Trustees Of Columbia University In The City Of New York Microneedles to deliver therapeutic agent across membranes background of the disclosed subject matter
CN115038476B (zh) * 2019-12-03 2024-09-24 索伦托药业有限公司 具有微针的流体递送设备
IL293479A (en) 2019-12-05 2022-08-01 Sorrento Therapeutics Inc Method of treating cancer by administration of an anti-pd-1 or anti-pd-l1 therapeutic agent via a lymphatic delivery device
CN111317911A (zh) * 2020-02-28 2020-06-23 广东工业大学 一种新型微针及其制造方法
WO2021183626A1 (en) 2020-03-10 2021-09-16 University Of Connecticut Therapeutic bandage
CN111467667B (zh) * 2020-04-17 2020-12-04 南京鼓楼医院 一种多层微针阵列及其制备方法
US12186515B2 (en) 2020-04-28 2025-01-07 Ticona Llc Microneedle assembly
US12491290B2 (en) 2020-06-08 2025-12-09 University Of Connecticut Biodegradable piezoelectric composite materials
CN111729189B (zh) * 2020-06-29 2023-01-06 嘉兴尚牧智能装备有限公司 硅基贴片及其制备方法
US20220000711A1 (en) * 2020-07-06 2022-01-06 Roman BURKO Acupressure medallion, method and device for its manufacture and method of reduction of pain from acupressure reflexotherapy
CN111688127A (zh) * 2020-07-08 2020-09-22 成都工业学院 一种微针芯片的注射成型模具及其制造方法
DK4048152T3 (da) 2020-07-29 2024-03-11 Biolinq Incorporated System til kontinuerlig analytovervågning med mikronålsindretning
US12280540B2 (en) 2020-09-27 2025-04-22 San Diego State University Research Foundation In situ partially degradable separation interface for fabrication of complex near net shape objects by pressure assisted sintering
US12552087B2 (en) 2020-12-11 2026-02-17 Solventum Intellectual Properties Company Method of thermoforming film with structured surface and articles
WO2022159736A1 (en) 2021-01-22 2022-07-28 Sorrento Therapeutics, Inc. Device for microliter-scale lymphatic delivery of coronavirus vaccines
WO2022192594A2 (en) 2021-03-11 2022-09-15 Sorrento Therapeutics, Inc. Nucleic acid molecules and vaccines comprising same for the prevention and treatment of coronavirus infections and disease
USD988160S1 (en) 2021-03-16 2023-06-06 Biolinq Incorporated Wearable dermal sensor
JP7653284B2 (ja) * 2021-03-30 2025-03-28 リンテック株式会社 突起保有体の製造方法および突起保有体の製造装置
US20240042395A1 (en) * 2021-04-02 2024-02-08 Donaldson Company, Inc. Patterned porous material surfaces
KR20240005085A (ko) 2021-05-08 2024-01-11 바이오링크 인코포레이티드 미세 바늘 어레이 기반 지속 분석물 모니터링 장치의 고장 감지
EP4347088A1 (en) 2021-05-27 2024-04-10 Donaldson Company, Inc. Structures having re-entrant geometries on a porous material surface
CN117916264A (zh) 2021-06-09 2024-04-19 索伦托药业有限公司 通过经由淋巴微针递送装置施用抗pd-1或抗pd-l1治疗剂来治疗癌症的方法
KR20240056524A (ko) 2021-08-18 2024-04-30 소렌토 쎄라퓨틱스, 인코포레이티드 림프계를 표적화하는 치료학적 제제
EP4344443A1 (en) 2021-08-31 2024-04-03 Illumina, Inc. Flow cell with enhanced well imaging resolution
CN113712547B (zh) * 2021-09-07 2023-12-29 集美大学 多槽微针阵列及其制备方法、生物检测微针传感器
ES2936735B2 (es) * 2021-09-20 2023-11-29 Paterna Jesus Paterna Dispositivo para preparar manualmente sistemas terapéuticos transdérmicos y procedimiento
CN114047234B (zh) * 2021-10-12 2023-06-13 中山大学 基于碳管/Mxenes的标志物检测装置及其制备方法
USD1013544S1 (en) 2022-04-29 2024-02-06 Biolinq Incorporated Wearable sensor
USD996999S1 (en) 2021-11-16 2023-08-29 Biolinq Incorporated Wearable sensor
CN114176492A (zh) * 2022-01-05 2022-03-15 深圳迈塔兰斯科技有限公司 内窥镜探头、内窥镜及其扫描控制方法
CN114216518B (zh) * 2022-01-18 2024-03-29 付涛 一种碱金属原子气室制备方法
KR102832416B1 (ko) * 2022-01-28 2025-07-10 동국대학교 산학협력단 바이오 의약품의 경피 전달용 용해성 마이크로니들 및 이의 제조 방법
KR102761831B1 (ko) * 2022-04-29 2025-02-04 서울과학기술대학교 산학협력단 마이크로니들 모듈 및 이를 포함하는 마이크로니들 장치
USD1012744S1 (en) 2022-05-16 2024-01-30 Biolinq Incorporated Wearable sensor with illuminated display
JP2026504447A (ja) 2023-02-02 2026-02-05 バイオリンク インコーポレイテッド マイクロニードルベースの持続分析物モニタリングシステムの改善されたセンサ感度のための方法
USD1083977S1 (en) 2023-02-28 2025-07-15 Biolinq Incorporated Display with graphical user interface for a wearable sensor
USD1068516S1 (en) 2023-02-28 2025-04-01 Biolinq Incorporated Wearable sensor
USD1035004S1 (en) 2023-02-28 2024-07-09 Biolinq Incorporated Wearable sensor
TWI849892B (zh) * 2023-05-08 2024-07-21 芯聖科技股份有限公司 量測微針長度的方法及其系統
USD1083640S1 (en) 2023-05-16 2025-07-15 Biolinq Incorporated Wearable sensor
WO2025129128A1 (en) 2023-12-15 2025-06-19 Vivasor, Inc. Compositions and methods for non-viral delivery of therapeutic compounds
KR20260000249A (ko) * 2024-06-25 2026-01-02 재단법인 아산사회복지재단 림프 타겟 무통증 약물 전달패치

Family Cites Families (227)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3797494A (en) 1969-04-01 1974-03-19 Alza Corp Bandage for the administration of drug by controlled metering through microporous materials
US3964482A (en) 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US4031894A (en) 1975-12-08 1977-06-28 Alza Corporation Bandage for transdermally administering scopolamine to prevent nausea
US4436741A (en) 1975-12-08 1984-03-13 Alza Corporation Method for administering scopolamine transdermally
US4051840A (en) 1976-01-05 1977-10-04 Sinai Hospital Of Detroit Dynamic aortic patch
US4201211A (en) 1977-07-12 1980-05-06 Alza Corporation Therapeutic system for administering clonidine transdermally
US4379454A (en) 1981-02-17 1983-04-12 Alza Corporation Dosage for coadministering drug and percutaneous absorption enhancer
JPS6058010B2 (ja) 1981-04-14 1985-12-18 三井化学株式会社 射出圧縮成形方法
US4661105A (en) 1981-06-29 1987-04-28 Alza Corporation Medical bandage for administering vasodilator drug
US4725272A (en) 1981-06-29 1988-02-16 Alza Corporation Novel bandage for administering beneficial drug
US5310559A (en) 1982-09-01 1994-05-10 Hercon Laboratories Corporation Device for controlled release and delivery to mammalian tissue of pharmacologically active agents incorporating a rate controlling member which comprises an alkylene-alkyl acrylate copolymer
US4515543A (en) 1983-09-02 1985-05-07 The Budd Co. In-mold coating part ejection system
US4588580B2 (en) 1984-07-23 1999-02-16 Alaz Corp Transdermal administration of fentanyl and device therefor
US4615699A (en) 1985-05-03 1986-10-07 Alza Corporation Transdermal delivery system for delivering nitroglycerin at high transdermal fluxes
US4681584A (en) 1985-05-03 1987-07-21 Alza Corporation Transdermal delivery system for delivering nitroglycerin at high transdermal fluxes
US4698062A (en) * 1985-10-30 1987-10-06 Alza Corporation Medical device for pulsatile transdermal delivery of biologically active agents
US4880633A (en) 1986-03-12 1989-11-14 Merck & Co., Inc. Transdermal drug delivery system
US4908027A (en) 1986-09-12 1990-03-13 Alza Corporation Subsaturated transdermal therapeutic system having improved release characteristics
US5344656A (en) 1986-09-12 1994-09-06 Alza Corporation Subsaturated transdermal therapeutic system having improved release characteristics
US4832953A (en) 1987-08-13 1989-05-23 Alza Corporation Method for preventing the formation of a crystalline hydrate in a dispersion of a liquid in a monaqueous matrix
US5364630A (en) 1988-06-14 1994-11-15 Alza Corporation Subsaturated nicotine transdermal therapeutic system
US5004610A (en) 1988-06-14 1991-04-02 Alza Corporation Subsaturated nicotine transdermal therapeutic system
US5328470A (en) 1989-03-31 1994-07-12 The Regents Of The University Of Michigan Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
JPH0938012A (ja) * 1995-05-24 1997-02-10 Nitomuzu:Kk 清掃用具
JP3172395B2 (ja) * 1995-06-14 2001-06-04 科学技術振興事業団 経皮薬剤放出デバイス
DE19525607A1 (de) 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
US5772905A (en) * 1995-11-15 1998-06-30 Regents Of The University Of Minnesota Nanoimprint lithography
US6248281B1 (en) 1996-11-14 2001-06-19 Idemitsu Petrochemical Co., Ltd. Compression apparatus for molding, injection compression molding machine, and injection compression molding method using the compression device
US6471993B1 (en) 1997-08-01 2002-10-29 Massachusetts Institute Of Technology Three-dimensional polymer matrices
WO1999032095A1 (en) 1997-12-22 1999-07-01 Alza Corporation Rate controlling membranes for controlled drug delivery devices
GB9805214D0 (en) 1998-03-11 1998-05-06 Univ Glasgow Cell adhesion
WO1999064580A1 (en) 1998-06-10 1999-12-16 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
GB9815819D0 (en) * 1998-07-22 1998-09-16 Secr Defence Transferring materials into cells and a microneedle array
US7048723B1 (en) 1998-09-18 2006-05-23 The University Of Utah Research Foundation Surface micromachined microneedles
TW480759B (en) * 1999-03-18 2002-03-21 Seiko Epson Corp Electronic machine, charged electronic machine and control method of electronic machine
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6312612B1 (en) 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US6256533B1 (en) 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6835184B1 (en) 1999-09-24 2004-12-28 Becton, Dickinson And Company Method and device for abrading skin
US6569143B2 (en) 1999-10-14 2003-05-27 Becton, Dickinson And Company Method of intradermally injecting substances
US20020095134A1 (en) 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
EP1235611B1 (en) * 1999-11-15 2005-09-07 Velcro Industries B.V. Skin attachment member
SE515607C2 (sv) 1999-12-10 2001-09-10 Obducat Ab Anordning och metod vid tillverkning av strukturer
EP1257878B1 (en) 2000-01-21 2006-07-05 Obducat Aktiebolag A mold for nano imprinting
IL134997A0 (en) 2000-03-09 2001-05-20 Yehoshua Yeshurun Health care system based on micro device
PT1309726E (pt) 2000-03-30 2010-03-08 Whitehead Biomedical Inst Mediadores de interferência por rna específicos de sequência de rna
SE516194C2 (sv) 2000-04-18 2001-12-03 Obducat Ab Substrat för samt process vid tillverkning av strukturer
SE516414C2 (sv) 2000-05-24 2002-01-15 Obducat Ab Metod vid tillverkning av en mall, samt mallen tillverkad därav
US7473244B2 (en) 2000-06-02 2009-01-06 The University Of Utah Research Foundation Active needle devices with integrated functionality
US6440096B1 (en) 2000-07-14 2002-08-27 Becton, Dickinson And Co. Microdevice and method of manufacturing a microdevice
US6656147B1 (en) 2000-07-17 2003-12-02 Becton, Dickinson And Company Method and delivery device for the transdermal administration of a substance
WO2002030506A2 (en) 2000-10-12 2002-04-18 Ink Jet Technology Ltd. Transdermal method
US7131987B2 (en) 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
US6821281B2 (en) 2000-10-16 2004-11-23 The Procter & Gamble Company Microstructures for treating and conditioning skin
US7828827B2 (en) 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
US6979347B1 (en) 2000-10-23 2005-12-27 Advanced Cardiovascular Systems, Inc. Implantable drug delivery prosthesis
NL1016779C2 (nl) * 2000-12-02 2002-06-04 Cornelis Johannes Maria V Rijn Matrijs, werkwijze voor het vervaardigen van precisieproducten met behulp van een matrijs, alsmede precisieproducten, in het bijzonder microzeven en membraanfilters, vervaardigd met een dergelijke matrijs.
CA2430888C (en) 2000-12-11 2013-10-22 President And Fellows Of Harvard College Nanosensors
WO2002064193A2 (en) 2000-12-14 2002-08-22 Georgia Tech Research Corporation Microneedle devices and production thereof
US7189435B2 (en) 2001-03-14 2007-03-13 University Of Massachusetts Nanofabrication
US6663820B2 (en) * 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
US6591124B2 (en) 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system
US6767341B2 (en) 2001-06-13 2004-07-27 Abbott Laboratories Microneedles for minimally invasive drug delivery
SE519573C2 (sv) 2001-07-05 2003-03-11 Obducat Ab Stamp med antividhäftningsskikt samt sätt att framställa och sätt att reparera en sådan stamp
SE0102736D0 (sv) 2001-08-14 2001-08-14 Patrick Griss Side opened out-of-plane microneedles for microfluidic transdermal interfacing and fabrication process of side opened out-of-plane microneedles
US6881203B2 (en) * 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
US6561143B2 (en) 2001-09-06 2003-05-13 Barry L Holtzman Engine induction valve with reduced backflow
ES2393282T3 (es) 2001-09-12 2012-12-20 Becton, Dickinson And Company Dispositivo de pluma basado en microaguja para la administración de fármacos
US20040087992A1 (en) 2002-08-09 2004-05-06 Vladimir Gartstein Microstructures for delivering a composition cutaneously to skin using rotatable structures
US8920375B2 (en) 2001-09-21 2014-12-30 Valeritas, Inc. Gas pressure actuated microneedle arrays, and systems and methods relating to same
US6746825B2 (en) 2001-10-05 2004-06-08 Wisconsin Alumni Research Foundation Guided self-assembly of block copolymer films on interferometrically nanopatterned substrates
US7429258B2 (en) 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
EP1490147A2 (en) 2002-03-04 2004-12-29 Nano Pass Technologies Ltd. Devices and methods for transporting fluid across a biological barrier
US7115108B2 (en) 2002-04-02 2006-10-03 Becton, Dickinson And Company Method and device for intradermally delivering a substance
WO2003092785A1 (en) 2002-04-30 2003-11-13 Morteza Shirkhanzadeh Arrays of microneedles comprising porous calcium phosphate coating and bioactive agents
US7033539B2 (en) 2002-05-24 2006-04-25 Baxter International Inc. Graphical user interface for automated dialysis system
US7252492B2 (en) 2002-06-20 2007-08-07 Obducat Ab Devices and methods for aligning a stamp and a substrate
AU2003239022A1 (en) 2002-06-20 2004-01-06 Obducat Ab Mold tool method of manufacturing a mold tool and storage medium formed by use of the mold tool
WO2004032990A2 (en) 2002-07-22 2004-04-22 Becton, Dickinson And Company Patch-like infusion device
AU2003259174A1 (en) 2002-07-24 2004-02-09 Mark D. Hughes Methods and compositions for on-line gas turbine cleaning
JP2005537656A (ja) 2002-08-27 2005-12-08 オブデュキャット、アクチボラグ 対象物にパターンを転写するための装置
US20040063100A1 (en) 2002-09-30 2004-04-01 Wang Chung Lin Nanoneedle chips and the production thereof
WO2004033021A1 (en) 2002-10-07 2004-04-22 Biovalve Technologies, Inc. Microneedle array patch
IL152912A0 (en) 2002-11-18 2003-06-24 Nanopass Ltd Micro needle systems
WO2004068553A2 (en) 2003-01-29 2004-08-12 The Regents Of The University Of Michigan Method for forming nanoscale features
US7374864B2 (en) * 2003-02-13 2008-05-20 The Regents Of The University Of Michigan Combined nanoimprinting and photolithography for micro and nano devices fabrication
US7578954B2 (en) 2003-02-24 2009-08-25 Corium International, Inc. Method for manufacturing microstructures having multiple microelements with through-holes
US7972616B2 (en) 2003-04-17 2011-07-05 Nanosys, Inc. Medical device applications of nanostructured surfaces
JP2006524120A (ja) 2003-04-21 2006-10-26 ストラテージェント ライフ サイエンシズ マイクロジェットで反復的に薬物を搬送する装置および方法
US7803574B2 (en) 2003-05-05 2010-09-28 Nanosys, Inc. Medical device applications of nanostructured surfaces
US7572405B2 (en) 2003-06-02 2009-08-11 Corium International Inc. Method for manufacturing microstructures having hollow microelements using fluidic jets during a molding operation
US7563451B2 (en) 2003-07-22 2009-07-21 Iowa State University Research Foundation, Inc. Capped mesoporous silicates
JP4884218B2 (ja) 2003-08-01 2012-02-29 バスカ，カナッグ 喉頭マスク
WO2005060396A2 (en) 2003-08-18 2005-07-07 The General Hospital Corporation Nanotopographic compositions and methods for cellular organization in tissue engineered structures
BRPI0413867A (pt) 2003-08-26 2006-10-24 Alza Corp dispositivo e método para implantação de célula intradérmica
US7544770B2 (en) 2003-08-29 2009-06-09 Louisiana Tech Foundation, Inc. Multilayer films, coatings, and microcapsules comprising polypeptides
US7862849B2 (en) 2003-10-17 2011-01-04 Massachusetts Institute Of Technology Nanocontact printing
DE10353629A1 (de) 2003-11-17 2005-06-16 Lts Lohmann Therapie-Systeme Ag Vorrichtung zur transdermalen Verabreichung von Wirkstoffen
US7753888B2 (en) 2003-11-21 2010-07-13 The Regents Of The University Of California Method and/or apparatus for puncturing a surface for extraction, in situ analysis, and/or substance delivery using microneedles
AU2004292953A1 (en) 2003-11-21 2005-06-09 Alza Corporation Ultrasound assisted transdermal vaccine delivery method and system
US20050119723A1 (en) 2003-11-28 2005-06-02 Medlogics Device Corporation Medical device with porous surface containing bioerodable bioactive composites and related methods
GB0402131D0 (en) 2004-01-30 2004-03-03 Isis Innovation Delivery method
WO2005075016A1 (ja) 2004-02-03 2005-08-18 Hisamitsu Pharmaceutical Co., Inc. 経皮薬物投与装置用インタフェース
WO2005082593A1 (en) 2004-02-17 2005-09-09 Avery Dennison Corporation Method of making microneedles
US20070191761A1 (en) 2004-02-23 2007-08-16 3M Innovative Properties Company Method of molding for microneedle arrays
US8915957B2 (en) 2004-03-11 2014-12-23 Alcatel Lucent Drug delivery stent
WO2005094526A2 (en) 2004-03-24 2005-10-13 Corium International, Inc. Transdermal delivery device
WO2005112636A2 (en) 2004-05-12 2005-12-01 Kamel Khalili COMPOSITIONS AND METHODS FOR siRNA INHIBITION OF PRIMATE POLYOMAVIRUS GENES
JP2005334594A (ja) 2004-05-27 2005-12-08 I-Com:Kk カーボンナノチューブ突起を有する薬剤投与パッチ
JP2008500914A (ja) 2004-05-28 2008-01-17 オブデュキャット、アクチボラグ インプリント方法に使用する変性された金属製成形型
US7315758B2 (en) 2004-06-03 2008-01-01 Lynntech, Inc. Transdermal delivery of therapeutic agent
US20060025848A1 (en) 2004-07-29 2006-02-02 Jan Weber Medical device having a coating layer with structural elements therein and method of making the same
US7537590B2 (en) 2004-07-30 2009-05-26 Microchips, Inc. Multi-reservoir device for transdermal drug delivery and sensing
US8696619B2 (en) 2004-08-10 2014-04-15 Robert P. Schnall Drug delivery devices
JPWO2006016647A1 (ja) 2004-08-12 2008-05-01 久光製薬株式会社 マイクロニードル付き経皮薬物投与装置
US7316665B2 (en) 2004-08-25 2008-01-08 Becton, Dickinson And Company Method and device for the delivery of a substance including a covering
DE102004041813A1 (de) 2004-08-26 2006-03-02 Siemens Ag Oberfläche mit einer haftungsvermindernden Mikrostruktur und Verfahren zu deren Herstellung
SE0402100D0 (sv) * 2004-08-30 2004-08-30 Bonsens Ab Molded micro-needles
US8137697B1 (en) 2004-10-05 2012-03-20 Gp Medical, Inc. Nanoparticles for protein/peptide delivery and delivery means thereof
US7449200B2 (en) 2006-04-17 2008-11-11 Gp Medical, Inc. Nanoparticles for protein/peptide delivery and delivery means
US7627938B2 (en) 2004-10-15 2009-12-08 Board Of Regents, The Univeristy Of Texas System Tapered hollow metallic microneedle array assembly and method of making and using the same
CN101102809B (zh) * 2004-11-18 2010-05-26 3M创新有限公司 涂敷微针阵列的遮蔽方法
CA2587387C (en) * 2004-11-18 2013-06-25 3M Innovative Properties Company Method of contact coating a microneedle array
US8057842B2 (en) 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
CA2587216C (en) 2004-11-18 2014-11-18 Nanopass Technologies Ltd. System and method for delivering fluid into flexible biological barrier
US8088321B2 (en) 2004-12-07 2012-01-03 3M Innovative Properties Company Method of molding a microneedle
CA2589730C (en) * 2004-12-10 2014-03-25 3M Innovative Properties Company Medical device
WO2006075689A1 (ja) 2005-01-14 2006-07-20 Fujikura Ltd. 医薬物運搬用器具とその製造方法
US20070112548A1 (en) 2005-02-18 2007-05-17 Georgia Tech Research Corporation Methods for fabricating micro-to-nanoscale devices via biologically-induced solid formation on biologically-derived templates, and micro-to-nanoscale structures and micro-to-nanoscale devices made thereby
US7855046B2 (en) 2005-04-07 2010-12-21 The University Of North Carolina At Charlotte Method and apparatus for fabricating shaped structures and shaped structures including one- , two- or three-dimensional patterns incorporated therein
US20080269666A1 (en) 2005-05-25 2008-10-30 Georgia Tech Research Corporation Microneedles and Methods for Microinfusion
EP1731960A1 (en) 2005-06-07 2006-12-13 Obducat AB Apparatus and method for separating a composite
DE602005012068D1 (de) 2005-06-10 2009-02-12 Obducat Ab Kopieren eines Musters mit Hilfe eines Zwischenstempels
WO2007002523A2 (en) 2005-06-24 2007-01-04 3M Innovative Properties Company Collapsible patch with microneedle array
JP2008543528A (ja) 2005-06-27 2008-12-04 スリーエム イノベイティブ プロパティズ カンパニー マイクロニードルカートリッジアセンブリ及び適用方法
CN101227940A (zh) * 2005-07-25 2008-07-23 纳米技术维多利亚有限公司 微阵列装置
US8118753B2 (en) 2005-08-18 2012-02-21 Seoul National University Industry Foundation Barb-wired micro needle made of single crystalline silicon and biopsy method and medicine injecting method using the same
CN101242869B (zh) 2005-09-02 2010-05-26 Iomai公司 经皮递送疫苗和透皮递送药物的装置及其应用
US7659252B2 (en) 2005-09-15 2010-02-09 Novomed Technologies, Inc. (Shanghai) Transdermal delivery peptides and method of use thereof
US20070066934A1 (en) 2005-09-19 2007-03-22 Transport Pharmaceuticals, Inc. Electrokinetic delivery system and methods therefor
US20070185432A1 (en) 2005-09-19 2007-08-09 Transport Pharmaceuticals, Inc. Electrokinetic system and method for delivering methotrexate
JP2007089792A (ja) * 2005-09-28 2007-04-12 Nano Device & System Research Inc 経皮投与装置
US20070078376A1 (en) 2005-09-30 2007-04-05 Smith Gregory A Functionalized microneedles transdermal drug delivery systems, devices, and methods
KR20080066712A (ko) 2005-09-30 2008-07-16 티티아이 엘뷰 가부시키가이샤 관능화된 미세바늘 경피 약물 전달 시스템, 장치 및 방법
US20070112309A1 (en) 2005-11-17 2007-05-17 Jerry Zucker Withdrawal syringe
US20080262416A1 (en) 2005-11-18 2008-10-23 Duan Daniel C Microneedle Arrays and Methods of Preparing Same
ATE549294T1 (de) 2005-12-09 2012-03-15 Obducat Ab Vorrichtung und verfahren zum transfer von mustern mit zwischenstempel
EP1962679B1 (en) * 2005-12-14 2012-04-11 Silex Microsystems AB Methods for making micro needles and applications thereof
US8944804B2 (en) 2006-01-04 2015-02-03 Liquidia Technologies, Inc. Nanostructured surfaces for biomedical/biomaterial applications and processes thereof
US7658728B2 (en) 2006-01-10 2010-02-09 Yuzhakov Vadim V Microneedle array, patch, and applicator for transdermal drug delivery
ATE532553T1 (de) 2006-02-10 2011-11-15 Hisamitsu Pharmaceutical Co Transdermales arzneiverabreichungsgerät mit mikronadeln
US20070224235A1 (en) 2006-03-24 2007-09-27 Barron Tenney Medical devices having nanoporous coatings for controlled therapeutic agent delivery
EP1998844A4 (en) 2006-03-24 2017-03-01 3M Innovative Properties Company Process for making microneedles, microneedle arrays, masters, and replication tools
WO2007116959A1 (ja) 2006-04-07 2007-10-18 Hisamitsu Pharmaceutical Co., Inc. マイクロニードルデバイスおよびマイクロニードル付き経皮薬物投与装置
CN1830496A (zh) 2006-04-10 2006-09-13 清华大学 “－”字形结构三维微型实心、空心硅针或刀
US9119945B2 (en) 2006-04-20 2015-09-01 3M Innovative Properties Company Device for applying a microneedle array
WO2007131050A2 (en) 2006-05-02 2007-11-15 Georgia Tech Research Corporation Method for drug delivery to ocular tissue using microneedle
AU2007288442A1 (en) 2006-05-09 2008-02-28 Apogee Technology, Inc. Nanofiber structures on asperities for sequestering, carrying and transferring substances
CN101448534B (zh) 2006-05-17 2012-10-03 生物技术公司 用于医疗植入物的各向异性纳米多孔涂层
US20070276318A1 (en) 2006-05-26 2007-11-29 Mit, Llp Iontosonic-microneedle applicator apparatus and methods
DE102006031506A1 (de) 2006-07-07 2008-01-17 Robert Bosch Gmbh Verfahren zur Herstellung von Mikronadeln in einem Si-Halbleitersubstrat
US20090182306A1 (en) 2006-07-21 2009-07-16 Georgia Tech Research Corporation Microneedle Devices and Methods of Drug Delivery or Fluid Withdrawal
EP2062611A4 (en) * 2006-08-18 2010-01-06 Toppan Printing Co Ltd MICRONADEL AND MICRONADEL
DE102006040642A1 (de) * 2006-08-30 2008-03-13 Robert Bosch Gmbh Mikronadeln zur Platzierung in der Haut zwecks transdermaler Applikation von Pharmazeutika
DE602007012559D1 (de) 2006-09-08 2011-03-31 Univ Johns Hopkins H die schleimhaut
US20080097352A1 (en) 2006-09-12 2008-04-24 Beck Patricia A Methods of fabricating microneedles with bio-sensory functionality
GB0620617D0 (en) 2006-10-17 2006-11-29 Glaxo Group Ltd Novel device
US20080091226A1 (en) 2006-10-17 2008-04-17 Nanopass Technologies Ltd. Microneedle device
WO2008115290A2 (en) 2006-10-25 2008-09-25 Revalesio Corporation Methods of wound care and treatment
JPWO2008062832A1 (ja) * 2006-11-22 2010-03-04 凸版印刷株式会社 マイクロニードルアレイ及びマイクロニードルアレイの製造方法
US7785301B2 (en) 2006-11-28 2010-08-31 Vadim V Yuzhakov Tissue conforming microneedle array and patch for transdermal drug delivery or biological fluid collection
US8238995B2 (en) * 2006-12-08 2012-08-07 General Electric Company Self-adhering electrodes and methods of making the same
CN101563022B (zh) 2006-12-22 2012-05-30 梅丁格有限公司 带体内电化学分析物感测的流体传输
EP3742655A1 (en) 2006-12-28 2020-11-25 Sharp Kabushiki Kaisha Radio transmission device, control device, radio communication system, and communication method
US8560059B2 (en) 2007-03-09 2013-10-15 Covidien Lp System and methods for optical sensing and drug delivery using microneedles
EP2164425B1 (en) 2007-03-16 2015-10-28 The Regents of The University of California Nanostructure surface coated medical implants and methods of using the same
JP2008237673A (ja) * 2007-03-28 2008-10-09 Toppan Printing Co Ltd 針状体およびその製造方法
CA2686093C (en) 2007-04-16 2018-05-08 Corium International, Inc. Solvent-cast microneedle arrays containing active
US20080311172A1 (en) 2007-04-25 2008-12-18 Schapira Jay N Programmed-release, nanostructured biological construct
AU2008283896A1 (en) 2007-08-06 2009-02-12 Transderm, Inc. Microneedle arrays formed from polymer films
US20100121307A1 (en) 2007-08-24 2010-05-13 Microfabrica Inc. Microneedles, Microneedle Arrays, Methods for Making, and Transdermal and/or Intradermal Applications
US20090093879A1 (en) 2007-10-04 2009-04-09 Debra Wawro Micro- and nano-patterned surface features to reduce implant fouling and regulate wound healing
US20090093871A1 (en) 2007-10-08 2009-04-09 Medtronic Vascular, Inc. Medical Implant With Internal Drug Delivery System
US20090099427A1 (en) 2007-10-12 2009-04-16 Arkal Medical, Inc. Microneedle array with diverse needle configurations
EP2231228A4 (en) 2007-12-17 2015-08-12 New World Pharmaceuticals Llc INTRADERMAL INTEGRATED ADMINISTRATION, DIAGNOSTIC AND COMMUNICATION SYSTEM
CA2745339C (en) 2007-12-24 2016-06-28 The University Of Queensland Coating method
JP2009207733A (ja) * 2008-03-05 2009-09-17 Toppan Printing Co Ltd 針状体
EP2100850A1 (en) 2008-03-11 2009-09-16 Stichting Voor De Technische Wetenschappen Microneedle array and a method for manufacturing microneedles
WO2009114719A2 (en) 2008-03-13 2009-09-17 Richmond Chemical Corporation Apparatus and method of retaining and releasing molecules from nanostructures by an external stimulus
EP2100820A1 (en) 2008-03-14 2009-09-16 Plaspapel S.L. Bag for packaging bread
US8870839B2 (en) * 2008-04-22 2014-10-28 The Procter & Gamble Company Disposable article including a nanostructure forming material
EP2294415A4 (en) 2008-05-23 2011-10-05 Univ Queensland DETECTION OF SUBSTANCES TO BE ANALYZED BY A MICRO-NEEDLE STAMPER WITH SELECTIVE REAGENTS
US20100004733A1 (en) 2008-07-02 2010-01-07 Boston Scientific Scimed, Inc. Implants Including Fractal Structures
US20100028604A1 (en) * 2008-08-01 2010-02-04 The Ohio State University Hierarchical structures for superhydrophobic surfaces and methods of making
CN101347652B (zh) 2008-09-09 2011-01-12 南京大学 一种空心微针阵列注射器的制备方法
MX386614B (es) 2008-09-22 2025-03-19 Biochemics Inc Suministro transdermico de farmaco empleando un osmolito y un agente vasoactivo.
US9040087B2 (en) * 2008-10-31 2015-05-26 The Invention Science Fund I, Llc Frozen compositions and methods for piercing a substrate
US20100130958A1 (en) 2008-11-26 2010-05-27 David Kang Device and Methods for Subcutaneous Delivery of High Viscosity Fluids
US20110021996A1 (en) 2008-12-18 2011-01-27 Miti Systems Inc. Structure of micro-needle with side channel and manufacturing method thereof
KR101039078B1 (ko) 2009-08-04 2011-06-07 (주)마이티시스템 이동되는 약물 저장 캡슐이 있는 미세바늘 약물 전달 시스템
EP2370141A1 (en) 2008-12-19 2011-10-05 Janisys Limited A fluid transfer device and an active substance cartridge for the fluid transfer device, and a method for controlling the pressure at which an active substance is delivered to a subject from a fluid transfer device
KR101087088B1 (ko) 2008-12-29 2011-11-25 한국과학기술연구원 나노 구조 패턴을 갖는 약물 방출용 스텐트의 제조방법 및 이로부터 제조된 약물 방출용 스텐트
KR101033513B1 (ko) 2009-01-20 2011-05-09 (주)마이티시스템 미세바늘을 이용한 유용성분 피부전달용 용기
CN102292114A (zh) 2009-01-27 2011-12-21 加州理工学院 通过具有从装置表面突出的排列的碳纳米管的纳米增强的装置促进的药物递送和物质传递
US8747886B2 (en) 2009-02-12 2014-06-10 Tufts University Nanoimprinting of silk fibroin structures for biomedical and biophotonic applications
WO2010123463A1 (en) 2009-04-23 2010-10-28 National University Of Singapore An apparatus that includes nano-sized projections and a method for manufacture thereof
WO2010126174A1 (en) 2009-05-01 2010-11-04 Nanbu Plastics Co., Ltd. Transdermal administration device
US8389205B2 (en) * 2009-06-11 2013-03-05 International Business Machines Corporation Patterning nano-scale patterns on a film comprising unzipping polymer chains
DE102009035795A1 (de) 2009-07-31 2011-02-03 Leibniz-Institut Für Neue Materialien Gemeinnützige Gmbh Struktuierte Oberflächen für Implantate
US20110144591A1 (en) 2009-12-11 2011-06-16 Ross Russell F Transdermal Delivery Device
US20110306853A1 (en) 2010-03-19 2011-12-15 Michael Darryl Black Body fluid sampling/fluid delivery device
US9115424B2 (en) * 2010-04-07 2015-08-25 California Institute Of Technology Simple method for producing superhydrophobic carbon nanotube array
WO2012046149A1 (en) 2010-04-28 2012-04-12 Kimberly-Clark Worldwide, Inc. Method for increasing permeability of an epithelial barrier
US9522262B2 (en) * 2010-04-28 2016-12-20 Kimberly-Clark Worldwide, Inc. Medical devices for delivery of siRNA
PT2563450T (pt) 2010-04-28 2017-08-28 Kimberly Clark Co Dispositivo para entrega de medicação para a artrite reumatóide
RU2570280C2 (ru) * 2010-04-28 2015-12-10 Кимберли-Кларк Ворлдвайд, Инк. Композитная матрица микроигл, содержащая на поверхности наноструктуры
WO2012006677A1 (en) 2010-07-14 2012-01-19 The University Of Queensland Patch applying apparatus
EP2632613B1 (en) 2010-10-28 2017-08-30 3M Innovative Properties Company Engineered surfaces for reducing bacterial adhesion
US9017289B2 (en) 2010-11-03 2015-04-28 Covidien Lp Transdermal fluid delivery device
CA2827158A1 (en) 2011-01-18 2012-07-26 Massachusetts Institute Of Technology Device and uses thereof
US8696637B2 (en) 2011-02-28 2014-04-15 Kimberly-Clark Worldwide Transdermal patch containing microneedles
PL3542851T3 (pl) 2011-10-27 2022-04-25 Sorrento Therapeutics, Inc. Wszczepialne urządzenia do dostarczania środków biologicznie czynnych
CN104039382B (zh) * 2011-10-27 2018-01-12 金伯利-克拉克环球有限公司 高粘度生物活性剂的经皮递送
US20170246439A9 (en) 2011-10-27 2017-08-31 Kimberly-Clark Worldwide, Inc. Increased Bioavailability of Transdermally Delivered Agents

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CN102958557B (zh) 2016-08-03
CN102958556B (zh) 2017-02-15
US12064582B2 (en) 2024-08-20
US20170143949A1 (en) 2017-05-25
US10806914B2 (en) 2020-10-20
JP2013529100A (ja) 2013-07-18
AU2011246881B2 (en) 2016-02-11
WO2011135533A2 (en) 2011-11-03
US20110270221A1 (en) 2011-11-03
WO2011135532A3 (en) 2012-03-15
CA2796198A1 (en) 2011-11-03
RU2012150726A (ru) 2014-06-10
MX2012012566A (es) 2012-11-21
BR112012027672A2 (pt) 2023-12-05
US20130165861A1 (en) 2013-06-27
ES2617284T3 (es) 2017-06-16
CN102958555A (zh) 2013-03-06
AU2011246882A1 (en) 2012-11-08
JP2016055196A (ja) 2016-04-21
JP5860453B2 (ja) 2016-02-16
AU2011246881A1 (en) 2012-11-08
US9545507B2 (en) 2017-01-17
EP2563453A2 (en) 2013-03-06
EP2563452A2 (en) 2013-03-06
US11179555B2 (en) 2021-11-23
RU2560646C2 (ru) 2015-08-20
MX343238B (es) 2016-10-27
JP5868953B2 (ja) 2016-02-24
KR101794377B1 (ko) 2017-11-06
EP2563453A4 (en) 2013-10-09
US10245421B2 (en) 2019-04-02
JP5871907B2 (ja) 2016-03-01
AU2011288209A1 (en) 2012-11-08
CA2796198C (en) 2019-05-28
EP2563452A4 (en) 2013-10-30
RU2012150731A (ru) 2014-06-10
US20130144217A1 (en) 2013-06-06
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WO2011135532A2 (en) 2011-11-03

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