JP5191537B2 - ヒトのプログラムされたデスレセプターｐｄ−１に対する抗体 - Google Patents
ヒトのプログラムされたデスレセプターｐｄ−１に対する抗体 Download PDFInfo
- Publication number
- JP5191537B2 JP5191537B2 JP2010513201A JP2010513201A JP5191537B2 JP 5191537 B2 JP5191537 B2 JP 5191537B2 JP 2010513201 A JP2010513201 A JP 2010513201A JP 2010513201 A JP2010513201 A JP 2010513201A JP 5191537 B2 JP5191537 B2 JP 5191537B2
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- seq
- amino acid
- human
- antibodies
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6869—Interleukin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/54—Interleukins [IL]
- G01N2333/55—IL-2
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- General Engineering & Computer Science (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94458307P | 2007-06-18 | 2007-06-18 | |
| US60/944,583 | 2007-06-18 | ||
| PCT/US2008/007463 WO2008156712A1 (en) | 2007-06-18 | 2008-06-13 | Antibodies to human programmed death receptor pd-1 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012185573A Division JP5640052B2 (ja) | 2007-06-18 | 2012-08-24 | ヒトのプログラムされたデスレセプターｐｄ−１に対する抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010530753A JP2010530753A (ja) | 2010-09-16 |
| JP2010530753A5 JP2010530753A5 (enExample) | 2011-03-10 |
| JP5191537B2 true JP5191537B2 (ja) | 2013-05-08 |
Family
ID=39760457
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010513201A Active JP5191537B2 (ja) | 2007-06-18 | 2008-06-13 | ヒトのプログラムされたデスレセプターｐｄ−１に対する抗体 |
| JP2012185573A Active JP5640052B2 (ja) | 2007-06-18 | 2012-08-24 | ヒトのプログラムされたデスレセプターｐｄ−１に対する抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012185573A Active JP5640052B2 (ja) | 2007-06-18 | 2012-08-24 | ヒトのプログラムされたデスレセプターｐｄ−１に対する抗体 |
Country Status (28)
| Country | Link |
|---|---|
| US (6) | US8354509B2 (enExample) |
| EP (3) | EP3222634A1 (enExample) |
| JP (2) | JP5191537B2 (enExample) |
| KR (3) | KR101586617B1 (enExample) |
| CN (2) | CN102131828B (enExample) |
| AU (1) | AU2008266951C1 (enExample) |
| BR (2) | BRPI0812913B8 (enExample) |
| CA (2) | CA2855098C (enExample) |
| CY (2) | CY1114849T1 (enExample) |
| DK (1) | DK2170959T3 (enExample) |
| ES (2) | ES2616355T3 (enExample) |
| HR (1) | HRP20131167T1 (enExample) |
| HU (1) | HUS1500071I1 (enExample) |
| IL (2) | IL202813A (enExample) |
| LT (1) | LTC2170959I2 (enExample) |
| LU (1) | LU92936I2 (enExample) |
| ME (1) | ME02093B (enExample) |
| MX (1) | MX2009014199A (enExample) |
| NL (1) | NL300788I2 (enExample) |
| NO (2) | NO2015028I1 (enExample) |
| NZ (2) | NZ600758A (enExample) |
| PH (1) | PH12015501524B1 (enExample) |
| PL (1) | PL2170959T3 (enExample) |
| PT (1) | PT2170959E (enExample) |
| RS (1) | RS53072B (enExample) |
| SI (1) | SI2170959T1 (enExample) |
| WO (1) | WO2008156712A1 (enExample) |
| ZA (1) | ZA201000135B (enExample) |
Families Citing this family (1544)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10347710B4 (de) | 2003-10-14 | 2006-03-30 | Johannes-Gutenberg-Universität Mainz | Rekombinante Impfstoffe und deren Verwendung |
| DE102005046490A1 (de) | 2005-09-28 | 2007-03-29 | Johannes-Gutenberg-Universität Mainz | Modifikationen von RNA, die zu einer erhöhten Transkriptstabilität und Translationseffizienz führen |
| CN101365479B (zh) | 2005-12-02 | 2013-06-26 | 纽约大学西奈山医学院 | 呈现非天然表面蛋白的嵌合病毒及其应用 |
| SI2170959T1 (sl) * | 2007-06-18 | 2014-04-30 | Merck Sharp & Dohme B.V. | Protitelesa proti receptorjem pd-1 za humano programirano smrt |
| EP2044949A1 (en) | 2007-10-05 | 2009-04-08 | Immutep | Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response |
| BRPI0820387A2 (pt) * | 2007-11-21 | 2015-05-26 | Amgen Inc | Agentes de ligação de wise e epítopos |
| US8168757B2 (en) | 2008-03-12 | 2012-05-01 | Merck Sharp & Dohme Corp. | PD-1 binding proteins |
| US9650639B2 (en) | 2008-05-19 | 2017-05-16 | Advaxis, Inc. | Dual delivery system for heterologous antigens |
| US9017660B2 (en) | 2009-11-11 | 2015-04-28 | Advaxis, Inc. | Compositions and methods for prevention of escape mutation in the treatment of Her2/neu over-expressing tumors |
| WO2009143167A2 (en) | 2008-05-19 | 2009-11-26 | Advaxis | Dual delivery system for heterologous antigens |
| SG2014010565A (en) | 2008-11-12 | 2014-05-29 | Merck Sharp & Dohme | ßGI-IGG INTRON FOR ENHANCED ANTI-IGF1 R EXPRESSION |
| HUE029577T2 (en) | 2009-03-30 | 2017-03-28 | Eisai R&D Man Co Ltd | Liposome preparation |
| WO2011034605A2 (en) | 2009-09-16 | 2011-03-24 | Genentech, Inc. | Coiled coil and/or tether containing protein complexes and uses thereof |
| US8709417B2 (en) | 2009-09-30 | 2014-04-29 | Memorial Sloan-Kettering Cancer Center | Combination immunotherapy for the treatment of cancer |
| US10016617B2 (en) | 2009-11-11 | 2018-07-10 | The Trustees Of The University Of Pennsylvania | Combination immuno therapy and radiotherapy for the treatment of Her-2-positive cancers |
| LT3279215T (lt) * | 2009-11-24 | 2020-04-10 | Medimmune Limited | Tiksliniai surišantys agentai prieš b7-h1 |
| US9045536B2 (en) * | 2009-12-23 | 2015-06-02 | Merck Sharp & Dohme Corp. | Cell line 3M |
| TW201134488A (en) * | 2010-03-11 | 2011-10-16 | Ucb Pharma Sa | PD-1 antibodies |
| WO2011110604A1 (en) * | 2010-03-11 | 2011-09-15 | Ucb Pharma, S.A. | Pd-1 antibody |
| AR080793A1 (es) | 2010-03-26 | 2012-05-09 | Roche Glycart Ag | Anticuerpos biespecificos |
| WO2012018538A2 (en) * | 2010-07-26 | 2012-02-09 | Schering Corporation | Bioassays for determining pd-1 modulation |
| EP2621527A4 (en) | 2010-10-01 | 2015-12-09 | Univ Pennsylvania | USE OF LISTERIA VACCINE VECTORS TO REVERSE VACCINE IMMUNITY IN PATIENTS WITH PARASITIC INFECTIONS |
| JP6162044B2 (ja) | 2010-12-23 | 2017-07-12 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 結合剤 |
| ES2656969T3 (es) * | 2010-12-23 | 2018-03-01 | F. Hoffmann-La Roche Ag | Detección de un dímero polipeptídico por un agente de unión bivalente |
| JP6046049B2 (ja) * | 2010-12-23 | 2016-12-14 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 二価結合剤による翻訳後修飾されたポリペプチドの検出 |
| SG191153A1 (en) | 2010-12-23 | 2013-07-31 | Hoffmann La Roche | Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery |
| CA2829960A1 (en) | 2011-03-11 | 2012-09-20 | John Rothman | Listeria-based adjuvants |
| PL2691112T3 (pl) | 2011-03-31 | 2018-09-28 | Merck Sharp & Dohme Corp. | Stabilne preparaty przeciwciał przeciw ludzkiemu receptorowi programowanej śmierci pd-1 i terapie powiązane |
| RS57324B1 (sr) * | 2011-04-20 | 2018-08-31 | Medimmune Llc | Antitela i drugi molekuli koji vezuju b7-h1 i pd-1 |
| CA2834548C (en) | 2011-04-28 | 2021-06-01 | The Broad Institute, Inc. | Inhibitors of histone deacetylase |
| RS64230B1 (sr) | 2011-05-24 | 2023-06-30 | BioNTech SE | Individualizovane vakcine protiv kancera |
| AU2012275390A1 (en) | 2011-06-28 | 2014-01-16 | Whitehead Institute For Biomedical Research | Using sortases to install click chemistry handles for protein ligation |
| EP2734205B1 (en) | 2011-07-21 | 2018-03-21 | Tolero Pharmaceuticals, Inc. | Heterocyclic protein kinase inhibitors |
| EP3939613A1 (en) | 2011-08-11 | 2022-01-19 | ONO Pharmaceutical Co., Ltd. | Therapeutic agent for autoimmune diseases comprising pd-1 agonist |
| US12466897B2 (en) | 2011-10-10 | 2025-11-11 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
| WO2013078223A1 (en) * | 2011-11-23 | 2013-05-30 | Children's Hospital & Research Center Oakland | Anti-factor h binding protein antibodies and methods of use thereof |
| GB201120779D0 (en) | 2011-12-02 | 2012-01-11 | Immodulon Therapeutics Ltd | Cancer therapy |
| WO2013116656A1 (en) * | 2012-02-03 | 2013-08-08 | Emory University | Immunostimulatory compositions, particles, and uses related thereto |
| JP6486686B2 (ja) | 2012-02-10 | 2019-03-20 | ジェネンテック， インコーポレイテッド | 単鎖抗体及び他のヘテロ多量体 |
| KR102099073B1 (ko) * | 2012-02-24 | 2020-04-10 | 애브비 스템센트알엑스 엘엘씨 | 항 ｓｅｚ6 항체들 및 사용 방법 |
| MX2014011061A (es) | 2012-03-12 | 2016-09-29 | Advaxis Inc | Inhibicion de funcion de celula supresora despues de tratamiento con vacuna listeria. |
| WO2013143555A1 (en) | 2012-03-26 | 2013-10-03 | Biontech Ag | Rna formulation for immunotherapy |
| EP3176170B1 (en) | 2012-06-13 | 2018-11-14 | Incyte Holdings Corporation | Substituted tricyclic compounds as fgfr inhibitors |
| CN110256567B (zh) | 2012-06-27 | 2023-04-25 | 弗·哈夫曼-拉罗切有限公司 | 用于选择并产生含有至少两种不同结合实体的定制靶向实体的方法及其用途 |
| JP6309002B2 (ja) | 2012-06-27 | 2018-04-11 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 標的に特異的に結合する少なくとも１つの結合実体を含む抗体Ｆｃ領域結合体を作製するための方法およびその使用 |
| RU2644263C2 (ru) * | 2012-06-27 | 2018-02-08 | Ф. Хоффманн-Ля Рош Аг | Способ отбора и получения селективных и мультиспецифических терапевтических молекул с заданными свойствами, включающих по меньшей мере две различные нацеливающие группировки, и их применения |
| AR091649A1 (es) | 2012-07-02 | 2015-02-18 | Bristol Myers Squibb Co | Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos |
| EP2877444B1 (en) | 2012-07-27 | 2020-09-02 | The Broad Institute, Inc. | Inhibitors of histone deacetylase |
| EP3981791A1 (en) | 2012-08-30 | 2022-04-13 | Amgen Inc. | A method for treating melanoma using a herpes simplex virus and an immune checkpoint inhibitor |
| MX2015002407A (es) | 2012-09-14 | 2015-06-22 | Hoffmann La Roche | Metodo para produccion y seleccion de moleculas que comprenden al menos dos entidades diferentes y usos del mismo. |
| DK2904011T3 (en) | 2012-10-02 | 2017-12-04 | Bristol Myers Squibb Co | COMBINATION OF ANTI-KIR ANTIBODIES AND ANTI-PD-1 ANTIBODIES FOR TREATMENT OF CANCER |
| AU2013351542B2 (en) | 2012-11-28 | 2018-08-09 | BioNTech SE | Individualized vaccines for cancer |
| US9328116B2 (en) | 2012-12-07 | 2016-05-03 | Chemocentryx, Inc. | Diazole lactams |
| UA117466C2 (uk) | 2012-12-13 | 2018-08-10 | Мерк Шарп Енд Доме Корп. | СТАБІЛЬНИЙ СКЛАД У ВИГЛЯДІ РОЗЧИНУ АНТИТІЛА ДО IL-23p19 |
| AR093984A1 (es) * | 2012-12-21 | 2015-07-01 | Merck Sharp & Dohme | Anticuerpos que se unen a ligando 1 de muerte programada (pd-l1) humano |
| US9657082B2 (en) | 2013-01-31 | 2017-05-23 | Thomas Jefferson University | PD-L1 and PD-L2-based fusion proteins and uses thereof |
| EP2958943B1 (en) | 2013-02-20 | 2019-09-11 | The Trustees Of The University Of Pennsylvania | Treatment of cancer using humanized anti-egfrviii chimeric antigen receptor |
| WO2014130635A1 (en) | 2013-02-20 | 2014-08-28 | Novartis Ag | Effective targeting of primary human leukemia using anti-cd123 chimeric antigen receptor engineered t cells |
| US11083743B2 (en) * | 2013-02-21 | 2021-08-10 | Michele Maio | DNA hypomethylating agents for cancer therapy |
| SG10201710473VA (en) | 2013-02-22 | 2018-02-27 | Curevac Ag | Combination of vaccination and inhibition of the pd-1 pathway |
| DK3292873T3 (da) * | 2013-02-22 | 2019-06-03 | Curevac Ag | Kombination af vaccination og hæmning af PD-1-vejen |
| ES2771251T3 (es) | 2013-03-01 | 2020-07-06 | Us Health | Métodos de producción de poblaciones enriquecidas de células T reactivas con tumores a partir de sangre periférica |
| WO2014158811A1 (en) | 2013-03-14 | 2014-10-02 | Icahn School Of Medicine At Mount Sinai | Newcastle disease viruses and uses thereof |
| US10858417B2 (en) | 2013-03-15 | 2020-12-08 | Xencor, Inc. | Heterodimeric proteins |
| TWI654206B (zh) | 2013-03-16 | 2019-03-21 | 諾華公司 | 使用人類化抗－ｃｄ１９嵌合抗原受體治療癌症 |
| US20160084839A1 (en) * | 2013-04-02 | 2016-03-24 | Marisa Dolled-Filhart | Immunohistochemical assay for detecting expression of programmed death ligand 1 (pd-l1) in tumor tissue |
| WO2014169078A2 (en) | 2013-04-09 | 2014-10-16 | Boston Biomedical, Inc. | Methods for treating cancer |
| EA201591931A1 (ru) | 2013-04-09 | 2016-05-31 | Ликсте Байотекнолоджи, Инк. | Композиции оксабициклогептанов и оксабициклогептенов |
| SG10201708520YA (en) | 2013-04-19 | 2017-12-28 | Incyte Corp | Bicyclic heterocycles as fgfr inhibitors |
| CN105339389B (zh) * | 2013-05-02 | 2021-04-27 | 安奈普泰斯生物有限公司 | 针对程序性死亡-1(pd-1)的抗体 |
| WO2014180490A1 (en) | 2013-05-10 | 2014-11-13 | Biontech Ag | Predicting immunogenicity of t cell epitopes |
| EP4119662A1 (en) | 2013-05-10 | 2023-01-18 | Whitehead Institute For Biomedical Research | Protein modification of living cells using sortase |
| EP3546484B1 (en) | 2013-05-10 | 2021-09-08 | Whitehead Institute for Biomedical Research | In vitro production of red blood cells with sortaggable proteins |
| EP3003316B1 (en) * | 2013-05-31 | 2020-07-22 | Merck Sharp & Dohme Corp. | Combination therapies for cancer |
| US9676853B2 (en) * | 2013-05-31 | 2017-06-13 | Sorrento Therapeutics, Inc. | Antigen binding proteins that bind PD-1 |
| CN104250302B (zh) * | 2013-06-26 | 2017-11-14 | 上海君实生物医药科技股份有限公司 | 抗pd‑1抗体及其应用 |
| BR112016001420A2 (pt) | 2013-08-02 | 2018-01-23 | Aduro Biotech Holdings Europe B V | combinação de agonistas de cd27 e inibição pontual imune para estimulação imune |
| DK3444271T3 (da) | 2013-08-08 | 2022-01-10 | Cytune Pharma | Il-15- og il-15r-alfa-sushi-domænebaserede modulokiner |
| HUE046964T2 (hu) | 2013-08-08 | 2020-04-28 | Cytune Pharma | Kombinált gyógyászati készítmény |
| WO2015026634A1 (en) * | 2013-08-20 | 2015-02-26 | Merck Sharp & Dohme Corp. | Treating cancer with a combination of a pd-1 antagonist and dinaciclib |
| AR097306A1 (es) | 2013-08-20 | 2016-03-02 | Merck Sharp & Dohme | Modulación de la inmunidad tumoral |
| SMT201800376T1 (it) | 2013-09-06 | 2018-09-13 | Aurigene Discovery Tech Ltd | Derivati di 1,2,4-ossadiazolo utilizzati come immunomodulatori |
| EA031325B1 (ru) | 2013-09-06 | 2018-12-28 | Ауриген Дискавери Текнолоджиз Лимитед | Циклические пептидомиметические соединения в качестве иммуномодуляторов |
| CN105849092A (zh) | 2013-09-06 | 2016-08-10 | 奥瑞基尼探索技术有限公司 | 作为免疫调节剂的1，3，4-*二唑和1，3，4-噻二唑衍生物 |
| US10077305B2 (en) | 2013-09-10 | 2018-09-18 | Medimmune Limited | Antibodies against PD-1 and uses thereof |
| ES2927567T3 (es) * | 2013-09-13 | 2022-11-08 | Beigene Switzerland Gmbh | Anticuerpos anti-PD1 y su uso como productos terapéuticos y de diagnóstico |
| EA036902B1 (ru) | 2013-09-20 | 2021-01-13 | Бристол-Майерс Сквибб Компани | Комбинирование anti-lag-3-антител и анти-pd-1-антител для лечения опухолей |
| WO2015048312A1 (en) | 2013-09-26 | 2015-04-02 | Costim Pharmaceuticals Inc. | Methods for treating hematologic cancers |
| CN104558177B (zh) * | 2013-10-25 | 2020-02-18 | 苏州思坦维生物技术股份有限公司 | 拮抗抑制程序性死亡受体pd-1与其配体结合的单克隆抗体及其编码序列与用途 |
| CN104560884A (zh) * | 2013-10-25 | 2015-04-29 | 苏州思坦维生物技术有限责任公司 | 拮抗抑制程序性死亡受体pd-1与其配体结合的单克隆抗体及分泌它的杂交瘤细胞系与用途 |
| WO2015066413A1 (en) | 2013-11-01 | 2015-05-07 | Novartis Ag | Oxazolidinone hydroxamic acid compounds for the treatment of bacterial infections |
| EP3065772B1 (en) * | 2013-11-05 | 2024-07-24 | Cognate Bioservices, Inc. | Combinations of checkpoint inhibitors and therapeutics to treat cancer |
| US9457019B2 (en) * | 2013-11-07 | 2016-10-04 | Deciphera Pharmaceuticals, Llc | Methods for inhibiting tie-2 kinase useful in the treatment of cancer |
| AU2014348657A1 (en) | 2013-11-13 | 2016-05-19 | Novartis Ag | mTOR inhibitors for enhancing the immune response |
| WO2015073746A2 (en) | 2013-11-13 | 2015-05-21 | Whitehead Institute For Biomedical Research | 18f labeling of proteins using sortases |
| US10241115B2 (en) | 2013-12-10 | 2019-03-26 | Merck Sharp & Dohme Corp. | Immunohistochemical proximity assay for PD-1 positive cells and PD-ligand positive cells in tumor tissue |
| US20160303231A1 (en) * | 2013-12-11 | 2016-10-20 | Robert Iannone | Treating cancer with a combination of a pd-1 antagonist and a vegfr inhibitor |
| LT3081576T (lt) | 2013-12-12 | 2019-10-25 | Shanghai hengrui pharmaceutical co ltd | Pd-1 antikūnas, antigeną surišantis jo fragmentas ir jų medicininis pritaikomumas |
| EP3084003A4 (en) | 2013-12-17 | 2017-07-19 | Merck Sharp & Dohme Corp. | Ifn-gamma gene signature biomarkers of tumor response to pd-1 antagonists |
| GB201322626D0 (en) | 2013-12-19 | 2014-02-05 | Immutep S A | Combined preparations for the treatment of cancer |
| SG11201604815RA (en) | 2013-12-19 | 2016-07-28 | Novartis Ag | Human mesothelin chimeric antigen receptors and uses thereof |
| GB201322725D0 (en) * | 2013-12-20 | 2014-02-05 | Immodulon Therapeutics Ltd | Cancer therapy |
| RU2761663C2 (ru) | 2013-12-20 | 2021-12-13 | Интервет Интернэшнл Б.В. | Антитела к pd-1 собак |
| US20170106065A1 (en) * | 2013-12-31 | 2017-04-20 | Bavarian Nordic A/S | Combination Therapy for Treating Cancer with a Poxvirus Expressing a Tumor Antigen and an Antagonist of TIM-3 |
| KR102395498B1 (ko) * | 2014-01-06 | 2022-05-09 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | Pd1 및 pdl1 항체 및 백신 조합 및 면역요법을 위한 이들의 사용 |
| CN105263521B (zh) * | 2014-01-15 | 2021-06-29 | 卡德门企业有限公司 | 免疫调节剂 |
| JO3517B1 (ar) | 2014-01-17 | 2020-07-05 | Novartis Ag | ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2 |
| TWI681969B (zh) * | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對ｐｄ-１的人類抗體 |
| TWI680138B (zh) | 2014-01-23 | 2019-12-21 | 美商再生元醫藥公司 | 抗ｐｄ-ｌ１之人類抗體 |
| JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
| JOP20200096A1 (ar) | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | جزيئات جسم مضاد لـ tim-3 واستخداماتها |
| EP3102604B1 (en) | 2014-02-04 | 2020-01-15 | Pfizer Inc | Combination of a pd-1 antagonist and a 4-1bb agonist for treating cancer |
| DK3102605T3 (en) | 2014-02-04 | 2019-02-25 | Pfizer | COMBINATION OF A PD-1 ANTAGONIST AND A VEGFR INHIBITOR FOR TREATMENT OF CANCER |
| AU2015214404B2 (en) | 2014-02-04 | 2020-10-01 | Incyte Corporation | Combination of a PD-1 antagonist and an IDO1 inhibitor for treating cancer |
| EP3441084A1 (en) | 2014-02-27 | 2019-02-13 | Viralytics Limited | Oncolytic virus and immuno-stimulatory agent for combined use in the treatment of cancer |
| US9732154B2 (en) | 2014-02-28 | 2017-08-15 | Janssen Biotech, Inc. | Anti-CD38 antibodies for treatment of acute lymphoblastic leukemia |
| US9603927B2 (en) | 2014-02-28 | 2017-03-28 | Janssen Biotech, Inc. | Combination therapies with anti-CD38 antibodies |
| CN106255510A (zh) | 2014-03-05 | 2016-12-21 | 百时美施贵宝公司 | 使用抗pd‑1抗体与另一抗癌剂的组合治疗肾癌 |
| US10519237B2 (en) | 2014-03-12 | 2019-12-31 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
| KR102248804B1 (ko) | 2014-03-12 | 2021-05-11 | 예다 리서치 앤드 디벨럽먼트 캄파니 리미티드 | Cns의 질환 및 손상을 치료하기 위한 전신적 조절 t 세포 수준 또는 활성의 감소 |
| US9394365B1 (en) | 2014-03-12 | 2016-07-19 | Yeda Research And Development Co., Ltd | Reducing systemic regulatory T cell levels or activity for treatment of alzheimer's disease |
| US10618963B2 (en) | 2014-03-12 | 2020-04-14 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
| WO2015135558A1 (en) | 2014-03-12 | 2015-09-17 | Curevac Gmbh | Combination of vaccination and ox40 agonists |
| EP3116909B1 (en) | 2014-03-14 | 2019-11-13 | Novartis Ag | Antibody molecules to lag-3 and uses thereof |
| CN106163547A (zh) | 2014-03-15 | 2016-11-23 | 诺华股份有限公司 | 使用嵌合抗原受体治疗癌症 |
| SMT201900218T1 (it) | 2014-03-24 | 2019-05-10 | Novartis Ag | Composti organici di monobattami, per il trattamento di infezioni batteriche |
| LT3129470T (lt) | 2014-04-07 | 2021-07-12 | Novartis Ag | Vėžio gydymas naudojant anti-cd19 chimerinį antigeno receptorių |
| US20170029567A1 (en) | 2014-04-15 | 2017-02-02 | Sabic Global Technologies B.V. | Methods of manufacture of polyetherimides |
| RU2695332C2 (ru) | 2014-05-15 | 2019-07-23 | Бристол-Маерс Сквибб Компани | Лечение рака легкого с помощью комбинации антитела против pd-1 и другого противоракового средства |
| CN106572993B (zh) | 2014-05-23 | 2019-07-16 | 卫材R&D管理有限公司 | Ep4拮抗剂在制备治疗癌症的药物中的应用 |
| KR20170005492A (ko) | 2014-05-28 | 2017-01-13 | 아이데닉스 파마슈티칼스 엘엘씨 | 암의 치료를 위한 뉴클레오시드 유도체 |
| JP6449338B2 (ja) | 2014-06-06 | 2019-01-09 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | グルココルチコイド誘導腫瘍壊死因子受容体（ｇｉｔｒ）に対する抗体およびその使用 |
| WO2015195163A1 (en) * | 2014-06-20 | 2015-12-23 | R-Pharm Overseas, Inc. | Pd-l1 antagonist fully human antibody |
| TWI693232B (zh) | 2014-06-26 | 2020-05-11 | 美商宏觀基因股份有限公司 | 與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法 |
| CN110156892B (zh) | 2014-07-03 | 2023-05-16 | 百济神州有限公司 | 抗pd-l1抗体及其作为治疗剂及诊断剂的用途 |
| AU2015286043B2 (en) | 2014-07-09 | 2020-08-20 | Birdie Biopharmaceuticals Inc. | Anti-PD-L1 combinations for treating tumors |
| WO2016009017A1 (en) | 2014-07-16 | 2016-01-21 | Institut Gustave-Roussy | Combination of oncolytic virus with immune checkpoint modulators |
| EP3169341B1 (en) | 2014-07-16 | 2019-06-05 | Transgene SA | Oncolytic virus for expression of immune checkpoint modulators |
| US9907849B2 (en) | 2014-07-18 | 2018-03-06 | Advaxis, Inc. | Combination of a PD-1 antagonist and a listeria-based vaccine for treating prostate cancer |
| WO2016014553A1 (en) | 2014-07-21 | 2016-01-28 | Novartis Ag | Sortase synthesized chimeric antigen receptors |
| WO2016014530A1 (en) | 2014-07-21 | 2016-01-28 | Novartis Ag | Combinations of low, immune enhancing. doses of mtor inhibitors and cars |
| CN107109419B (zh) | 2014-07-21 | 2020-12-22 | 诺华股份有限公司 | 使用cd33嵌合抗原受体治疗癌症 |
| EP3171892B1 (en) | 2014-07-22 | 2021-11-24 | Apollomics Inc. | Anti-pd-1 antibodies |
| CN105330740B (zh) * | 2014-07-30 | 2018-08-17 | 珠海市丽珠单抗生物技术有限公司 | 抗pd-1抗体及其应用 |
| EP4205749A1 (en) | 2014-07-31 | 2023-07-05 | Novartis AG | Subset-optimized chimeric antigen receptor-containing cells |
| EP3177644B1 (en) | 2014-08-05 | 2020-10-07 | Mabquest SA | Immunological reagents binding to pd-1 |
| CN110964108B (zh) | 2014-08-05 | 2023-07-07 | 中美冠科生物技术（太仓）有限公司 | 抗pd-l1抗体 |
| US9982052B2 (en) | 2014-08-05 | 2018-05-29 | MabQuest, SA | Immunological reagents |
| US10160726B2 (en) | 2014-08-06 | 2018-12-25 | Novartis Ag | Quinolone derivatives as antibacterials |
| CN106794246B (zh) * | 2014-08-08 | 2021-10-15 | OncoQuest制药有限公司 | 肿瘤抗原特异性抗体和tlr3刺激以增强检查点干扰癌症疗法的性能 |
| PT3179992T (pt) | 2014-08-11 | 2022-07-12 | Acerta Pharma Bv | Combinações terapêuticas de um inibidor de btk, um inibidor de pd-1 e/ou um inibidor de pd-l1 |
| CA2958200A1 (en) | 2014-08-14 | 2016-02-18 | Novartis Ag | Treatment of cancer using a gfr alpha-4 chimeric antigen receptor |
| KR20170035945A (ko) * | 2014-08-14 | 2017-03-31 | 에프. 호프만-라 로슈 아게 | 인간 cd40을 활성화시키는 항체 및 인간 pd-l1에 대한 항체의 병용 요법 |
| ES2791248T3 (es) | 2014-08-19 | 2020-11-03 | Novartis Ag | Receptor antigénico quimérico (CAR) anti-CD123 para su uso en el tratamiento del cáncer |
| JO3663B1 (ar) | 2014-08-19 | 2020-08-27 | Merck Sharp & Dohme | الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين |
| EP3185866A1 (en) * | 2014-08-25 | 2017-07-05 | Pfizer Inc. | Combination of a pd-1 antagonist and an alk inhibitor for treating cancer |
| ES2727137T3 (es) | 2014-08-28 | 2019-10-14 | Halozyme Inc | Terapia combinada con una enzima de degradación de hialuronano y un inhibidor de puntos de control inmunitario |
| CN112587672A (zh) | 2014-09-01 | 2021-04-02 | 博笛生物科技有限公司 | 用于治疗肿瘤的抗-pd-l1结合物 |
| US9535074B2 (en) | 2014-09-08 | 2017-01-03 | Merck Sharp & Dohme Corp. | Immunoassay for soluble PD-L1 |
| AU2015314756A1 (en) | 2014-09-13 | 2017-03-16 | Novartis Ag | Combination therapies of alk inhibitors |
| HUE051193T2 (hu) | 2014-09-16 | 2021-03-01 | Innate Pharma | Gátlási reakcióút semlegesítése limfocitákban |
| EA201790624A1 (ru) | 2014-09-17 | 2017-08-31 | Новартис Аг | Нацеливание цитотоксических клеток с химерными рецепторами для адоптивной иммунотерапии |
| WO2016045732A1 (en) | 2014-09-25 | 2016-03-31 | Biontech Rna Pharmaceuticals Gmbh | Stable formulations of lipids and liposomes |
| US10428143B2 (en) * | 2014-09-28 | 2019-10-01 | The Regents Of The University Of California | Modulation of stimulatory and non-stimulatory myeloid cells |
| CA2961987A1 (en) | 2014-09-30 | 2016-04-07 | Intervet International B.V. | Pd-l1 antibodies binding canine pd-l1 |
| EP3662903A3 (en) | 2014-10-03 | 2020-10-14 | Novartis AG | Combination therapies |
| US10053683B2 (en) | 2014-10-03 | 2018-08-21 | Whitehead Institute For Biomedical Research | Intercellular labeling of ligand-receptor interactions |
| MA41044A (fr) | 2014-10-08 | 2017-08-15 | Novartis Ag | Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer |
| AU2015330898B2 (en) | 2014-10-08 | 2022-03-10 | Novartis Ag | Biomarkers predictive of therapeutic responsiveness to chimeric antigen receptor therapy and uses thereof |
| JP6991857B2 (ja) | 2014-10-10 | 2022-01-13 | イデラ ファーマシューティカルズ インコーポレイテッド | Ｔｌｒ９アゴニストをチェックポイント阻害剤と共に用いるがんの治療 |
| CN114920840A (zh) * | 2014-10-14 | 2022-08-19 | 诺华股份有限公司 | 针对pd-l1的抗体分子及其用途 |
| CA3126536C (en) | 2014-10-14 | 2023-07-25 | Halozyme, Inc. | Compositions of adenosine deaminase-2 (ada2), variants thereof and methods of using same |
| GB201419084D0 (en) | 2014-10-27 | 2014-12-10 | Agency Science Tech & Res | Anti-PD-1 antibodies |
| WO2016069727A1 (en) | 2014-10-29 | 2016-05-06 | Five Prime Therapeutics, Inc. | Combination therapy for cancer |
| US11236139B2 (en) | 2014-11-05 | 2022-02-01 | The Regents Of The University Of California | Combination immunotherapy |
| PE20170912A1 (es) | 2014-11-14 | 2017-07-12 | Novartis Ag | Conjugados de anticuerpo-farmaco |
| US20160169869A1 (en) | 2014-11-20 | 2016-06-16 | Promega Corporation | Systems and methods for assessing modulators of immune checkpoints |
| BR112017011092A2 (pt) | 2014-11-26 | 2017-12-26 | Xencor Inc | anticorpos heterodiméricos que ligam cd3 e antígenos de tumor |
| CN107001482B (zh) | 2014-12-03 | 2021-06-15 | 豪夫迈·罗氏有限公司 | 多特异性抗体 |
| WO2016090034A2 (en) | 2014-12-03 | 2016-06-09 | Novartis Ag | Methods for b cell preconditioning in car therapy |
| EA201791049A1 (ru) | 2014-12-04 | 2017-10-31 | Бристол-Майерс Сквибб Компани | Комбинация анти-cs1 и анти-pd1 антител для лечения рака (миеломы) |
| UA123697C2 (uk) | 2014-12-04 | 2021-05-19 | Янссен Байотек, Інк. | Спосіб лікування гострого мієлоїдного лейкозу шляхом застосування антитіла до cd38 |
| US10442819B2 (en) | 2014-12-05 | 2019-10-15 | Merck Sharp & Dohme Corp. | Tricyclic compounds as inhibitors of mutant IDH enzymes |
| EP3227337A1 (en) | 2014-12-05 | 2017-10-11 | F. Hoffmann-La Roche AG | Methods and compositions for treating cancer using pd-1 axis antagonists and hpk1 antagonists |
| US10086000B2 (en) | 2014-12-05 | 2018-10-02 | Merck Sharp & Dohme Corp. | Tricyclic compounds as inhibitors of mutant IDH enzymes |
| WO2016089830A1 (en) | 2014-12-05 | 2016-06-09 | Merck Sharp & Dohme Corp. | Novel tricyclic compounds as inhibitors of mutant idh enzymes |
| TWI595006B (zh) | 2014-12-09 | 2017-08-11 | 禮納特神經系統科學公司 | 抗ｐｄ－１抗體類和使用彼等之方法 |
| CN107109700A (zh) | 2014-12-09 | 2017-08-29 | 默沙东公司 | 用于推导对pd‑1拮抗剂的反应的基因特征生物标志物的系统和方法 |
| CR20170260A (es) | 2014-12-16 | 2017-08-21 | Novartis Ag | COMPUESTOS DE ISOXAZOL DE ÁCIDO HIDROXÁMICO COMO INHIBIDORES DE LpxC |
| IL300202B2 (en) | 2014-12-18 | 2024-04-01 | Amgen Inc | Stable frozen formulation for herpes simplex virus |
| WO2016100882A1 (en) | 2014-12-19 | 2016-06-23 | Novartis Ag | Combination therapies |
| US11639385B2 (en) | 2014-12-22 | 2023-05-02 | Pd-1 Acquisition Group, Llc | Anti-PD-1 antibodies |
| WO2016106159A1 (en) * | 2014-12-22 | 2016-06-30 | Enumeral Biomedical Holding, Inc. | Anti-pd-1 antibodies |
| CN105820247A (zh) * | 2014-12-31 | 2016-08-03 | 三生国健药业（上海）股份有限公司 | 一种筛选pd-1抗体的方法 |
| WO2016111947A2 (en) | 2015-01-05 | 2016-07-14 | Jounce Therapeutics, Inc. | Antibodies that inhibit tim-3:lilrb2 interactions and uses thereof |
| GB201500374D0 (en) * | 2015-01-09 | 2015-02-25 | Immutep S A | Combined preparations for the treatment of cancer |
| US11786457B2 (en) | 2015-01-30 | 2023-10-17 | President And Fellows Of Harvard College | Peritumoral and intratumoral materials for cancer therapy |
| US11161907B2 (en) | 2015-02-02 | 2021-11-02 | Novartis Ag | Car-expressing cells against multiple tumor antigens and uses thereof |
| WO2016128060A1 (en) | 2015-02-12 | 2016-08-18 | Biontech Ag | Predicting t cell epitopes useful for vaccination |
| WO2016128912A1 (en) | 2015-02-12 | 2016-08-18 | Acerta Pharma B.V. | Therapeutic combinations of a btk inhibitor, a pi3k inhibitor, a jak-2 inhibitor, a pd-1 inhibitor, and/or a pd-l1 inhibitor |
| ES3011733T3 (en) | 2015-02-13 | 2025-04-08 | Transgene | Immunotherapeutic vaccine and antibody combination therapy |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| MX373169B (es) | 2015-02-20 | 2020-04-24 | Incyte Holdings Corp | Heterociclos bicíclicos como inhibidores de receptores del factor de crecimiento fibroblástico (fgfr). |
| US10800846B2 (en) | 2015-02-26 | 2020-10-13 | Merck Patent Gmbh | PD-1/PD-L1 inhibitors for the treatment of cancer |
| AR103726A1 (es) | 2015-02-27 | 2017-05-31 | Merck Sharp & Dohme | Cristales de anticuerpos monoclonales anti-pd-1 humanos |
| KR20170122810A (ko) | 2015-03-04 | 2017-11-06 | 머크 샤프 앤드 돔 코포레이션 | 암을 치료하기 위한 pd-1 길항제 및 에리불린의 조합 |
| KR20250020678A (ko) | 2015-03-04 | 2025-02-11 | 머크 샤프 앤드 돔 엘엘씨 | 암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합 |
| CN114159430B (zh) | 2015-03-10 | 2024-10-25 | 奥瑞基尼探索技术有限公司 | 作为免疫调节剂的1,2,4-噁二唑和噻二唑化合物 |
| JP6692826B2 (ja) | 2015-03-10 | 2020-05-13 | アドゥロ バイオテック，インク． | 「インターフェロン遺伝子刺激因子」依存性シグナル伝達の活性化のための組成物及び方法 |
| CN108112254B (zh) | 2015-03-13 | 2022-01-28 | 西托姆克斯治疗公司 | 抗-pdl1抗体、可活化的抗-pdl1抗体、及其使用方法 |
| WO2016146143A1 (en) | 2015-03-16 | 2016-09-22 | Amal Therapeutics Sa | Cell penetrating peptides and complexes comprising the same |
| SI3274370T1 (sl) | 2015-03-23 | 2020-02-28 | Bayer Pharma Aktiengesellschaft | Protitelesa proti CEACAM6 in njihova uporaba |
| KR102610592B1 (ko) | 2015-03-30 | 2023-12-07 | 주식회사 에스티큐브 | 당화 pd-l1에 특이적인 항체 및 그의 사용 방법 |
| US11933786B2 (en) | 2015-03-30 | 2024-03-19 | Stcube, Inc. | Antibodies specific to glycosylated PD-L1 and methods of use thereof |
| MA41867B1 (fr) | 2015-04-01 | 2024-11-29 | Anaptysbio, Inc. | Anticorps dirigés contre l'immunoglobuline de cellule t et protéine 3 de mucine (tim-3) |
| EP3277716B1 (en) | 2015-04-03 | 2020-06-24 | XOMA Technology Ltd. | Treatment of cancer using inhibitors of tgf-beta and pd-1 |
| RU2709015C2 (ru) | 2015-04-07 | 2019-12-13 | Ситлимик Инк. | Лекарственное средство |
| ES2876974T3 (es) | 2015-04-07 | 2021-11-15 | Novartis Ag | Combinación de terapia con receptor de antígeno quimérico y derivados de amino pirimidina |
| EP3283882B2 (en) | 2015-04-17 | 2024-10-16 | Merck Sharp & Dohme LLC | Blood-based biomarkers of tumor sensitivity to pd-1 antagonists |
| EP4234685A3 (en) | 2015-04-17 | 2023-09-06 | Novartis AG | Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells |
| KR102740444B1 (ko) | 2015-04-17 | 2024-12-10 | 브리스톨-마이어스 스큅 컴퍼니 | 항-pd-1 항체 및 또 다른 항체의 조합물을 포함하는 조성물 |
| US12128069B2 (en) | 2015-04-23 | 2024-10-29 | The Trustees Of The University Of Pennsylvania | Treatment of cancer using chimeric antigen receptor and protein kinase a blocker |
| WO2016176504A1 (en) | 2015-04-28 | 2016-11-03 | Bristol-Myers Squibb Company | Treatment of pd-l1-positive melanoma using an anti-pd-1 antibody |
| US10174113B2 (en) | 2015-04-28 | 2019-01-08 | Bristol-Myers Squibb Company | Treatment of PD-L1-negative melanoma using an anti-PD-1 antibody and an anti-CTLA-4 antibody |
| WO2016179194A1 (en) | 2015-05-04 | 2016-11-10 | Jounce Therapeutics, Inc. | Lilra3 and method of using the same |
| DK3291679T3 (da) | 2015-05-06 | 2022-01-17 | Snipr Tech Ltd | Ændring af mikrobielle populationer og modificering af mikrobiota |
| CN104987421A (zh) * | 2015-05-13 | 2015-10-21 | 北京比洋生物技术有限公司 | 抗ctla-4和pd-1的双重可变结构域免疫球蛋白 |
| ES2739749T3 (es) | 2015-05-18 | 2020-02-03 | Tolero Pharmaceuticals Inc | Profármacos de alvocidib que tienen biodisponibilidad aumentada |
| AU2016264725B2 (en) | 2015-05-20 | 2021-05-27 | Janssen Biotech, Inc. | Anti-CD38 antibodies for treatment of light chain amyloidosis and other CD38-positive hematological malignancies |
| PT3297438T (pt) | 2015-05-21 | 2022-01-25 | Chemocentryx Inc | Moduladores de ccr2 |
| AU2016263808B2 (en) | 2015-05-21 | 2019-01-03 | Harpoon Therapeutics, Inc. | Trispecific binding proteins and methods of use |
| WO2016189055A1 (en) | 2015-05-27 | 2016-12-01 | Idenix Pharmaceuticals Llc | Nucleotides for the treatment of cancer |
| WO2016191751A1 (en) | 2015-05-28 | 2016-12-01 | Bristol-Myers Squibb Company | Treatment of pd-l1 positive lung cancer using an anti-pd-1 antibody |
| DK3303394T3 (da) | 2015-05-29 | 2020-07-06 | Agenus Inc | Anti-ctla-4-antistoffer og fremgangsmåder til anvendelse deraf |
| US11078278B2 (en) | 2015-05-29 | 2021-08-03 | Bristol-Myers Squibb Company | Treatment of renal cell carcinoma |
| EP3892284B1 (en) | 2015-05-29 | 2024-05-22 | Merck Sharp & Dohme LLC | Combination of a pd-1 antagonist and a cpg-c type oligonucleotide for treating cancer |
| US20180153884A1 (en) | 2015-05-31 | 2018-06-07 | Curegenix Corporation | Combination compositions for immunotherapy |
| JP2018521979A (ja) | 2015-06-03 | 2018-08-09 | ボストン バイオメディカル， インコーポレイテッド | 癌の治療に使用するための癌幹細胞性阻害剤および免疫療法剤を含む組成物 |
| TWI773646B (zh) | 2015-06-08 | 2022-08-11 | 美商宏觀基因股份有限公司 | 結合lag-3的分子和其使用方法 |
| CN105061597B (zh) * | 2015-06-09 | 2016-04-27 | 北京东方百泰生物科技有限公司 | 一种抗pd-1的单克隆抗体及其获得方法 |
| KR102661066B1 (ko) | 2015-06-12 | 2024-04-25 | 매카이 메디컬 파운데이션 더 프레즈비티리언 처치 인 타이완 매카이 메모리얼 호스피탈 | 면역반응의 조절을 위한 방법 및 항체 |
| TWI870335B (zh) | 2015-06-12 | 2025-01-21 | 美商宏觀基因股份有限公司 | 變異的嵌合4d5抗體及其與抗pd-1抗體聯合用於治療癌症的應用 |
| CN108026173A (zh) | 2015-06-12 | 2018-05-11 | 百时美施贵宝公司 | 通过联合阻断pd-1和cxcr4信号传导途径治疗癌症 |
| US10869924B2 (en) | 2015-06-16 | 2020-12-22 | Merck Patent Gmbh | PD-L1 antagonist combination treatments |
| US20190194315A1 (en) | 2015-06-17 | 2019-06-27 | Novartis Ag | Antibody drug conjugates |
| TWI773647B (zh) * | 2015-06-23 | 2022-08-11 | 史隆凱特林紀念癌症中心 | 新穎pd-1免疫調控劑 |
| WO2016207646A1 (en) | 2015-06-24 | 2016-12-29 | Immodulon Therapeutics Limited | A checkpoint inhibitor and a whole cell mycobacterium for use in cancer therapy |
| FI3313441T3 (fi) | 2015-06-24 | 2024-03-28 | Janssen Biotech Inc | Kiinteiden kasvainten immunomodulaatio ja hoito spesifisesti cd38:aa sitovilla vasta-aineilla |
| AU2016288246A1 (en) | 2015-07-02 | 2018-02-01 | Celgene Corporation | Combination therapy for treatment of hematological cancers and solid tumors |
| GB201511790D0 (en) | 2015-07-06 | 2015-08-19 | Iomet Pharma Ltd | Pharmaceutical compound |
| CN108368170B (zh) * | 2015-07-13 | 2022-04-15 | 西托姆克斯治疗公司 | 抗pd-1抗体、可活化抗pd-1抗体及其使用方法 |
| EP4679094A2 (en) | 2015-07-14 | 2026-01-14 | Bristol-Myers Squibb Company | Method of treating cancer using immune checkpoint inhibitor; antibody that binds to programmed death-1 receptor (pd-1) or programmed death ligand 1 (pd-l1) |
| MA42459A (fr) | 2015-07-16 | 2018-05-23 | Bioxcel Therapeutics Inc | Nouvelle approche pour le traitement du cancer par immunomodulation |
| CN107921087A (zh) | 2015-07-16 | 2018-04-17 | 百欧肯治疗有限公司 | 治疗癌症的组合物及方法 |
| CN109476722A (zh) | 2015-07-21 | 2019-03-15 | 诺华股份有限公司 | 用于改善免疫细胞的功效和扩张的方法 |
| CN114272371A (zh) | 2015-07-29 | 2022-04-05 | 诺华股份有限公司 | 包含抗pd-1抗体分子的联合疗法 |
| PT3317301T (pt) | 2015-07-29 | 2021-07-09 | Novartis Ag | Terapias de associação compreendendo moléculas de anticorpo contra lag-3 |
| WO2017019897A1 (en) | 2015-07-29 | 2017-02-02 | Novartis Ag | Combination therapies comprising antibody molecules to tim-3 |
| WO2017019846A1 (en) | 2015-07-30 | 2017-02-02 | Macrogenics, Inc. | Pd-1-binding molecules and methods use thereof |
| CN106397592A (zh) * | 2015-07-31 | 2017-02-15 | 苏州康宁杰瑞生物科技有限公司 | 针对程序性死亡配体(pd-l1)的单域抗体及其衍生蛋白 |
| JP7062290B2 (ja) | 2015-07-31 | 2022-05-06 | ユニバーシティー オブ フロリダ リサーチ ファンデーション， インク． | がんに対する免疫チェックポイント阻害剤との併用療法における造血幹細胞 |
| WO2017023671A1 (en) * | 2015-08-03 | 2017-02-09 | Constellation Pharmaceuticals, Inc. | Ezh2 inhibitors and modulation of regulatory t-cell function |
| EP3331918A1 (en) * | 2015-08-04 | 2018-06-13 | GlaxoSmithKline Intellectual Property Development Limited | Combination treatments and uses and methods thereof |
| HK1254450A1 (zh) | 2015-08-07 | 2019-07-19 | Pieris Pharmaceuticals Gmbh | 对lag-3和pd-1特异性的新型融合多肽 |
| US20180230431A1 (en) | 2015-08-07 | 2018-08-16 | Glaxosmithkline Intellectual Property Development Limited | Combination Therapy |
| WO2017024465A1 (en) | 2015-08-10 | 2017-02-16 | Innovent Biologics (Suzhou) Co., Ltd. | Pd-1 antibodies |
| RU2020124273A (ru) | 2015-08-11 | 2020-12-03 | Уси Байолоджикс (Кайман) Инк. | Новые анти-pd-1 антитела |
| US11453697B1 (en) | 2015-08-13 | 2022-09-27 | Merck Sharp & Dohme Llc | Cyclic di-nucleotide compounds as sting agonists |
| CN108137641B (zh) | 2015-08-13 | 2022-04-01 | 默沙东公司 | 作为sting激动剂的环状双核苷酸化合物 |
| AR105654A1 (es) * | 2015-08-24 | 2017-10-25 | Lilly Co Eli | Anticuerpos pd-l1 (ligando 1 de muerte celular programada) |
| EP3341732B1 (en) | 2015-08-27 | 2023-07-12 | INSERM - Institut National de la Santé et de la Recherche Médicale | Methods for predicting the survival time of patients suffering from a lung cancer |
| KR102434314B1 (ko) * | 2015-09-01 | 2022-08-19 | 아게누스 인코포레이티드 | 항-pd-1 항체 및 이를 이용하는 방법 |
| CN108780084B (zh) | 2015-09-03 | 2022-07-22 | 诺华股份有限公司 | 预测细胞因子释放综合征的生物标志物 |
| CA2996685A1 (en) | 2015-09-03 | 2017-03-09 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| PT3345618T (pt) * | 2015-09-03 | 2022-02-02 | Ono Pharmaceutical Co | Agente para aumentar a imunidade ao cancro usando o antagonista da alergina-1 |
| NZ740616A (en) | 2015-09-14 | 2023-05-26 | Infinity Pharmaceuticals Inc | Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same |
| MA44909A (fr) | 2015-09-15 | 2018-07-25 | Acerta Pharma Bv | Association thérapeutique d'un inhibiteur du cd19 et d'un inhibiteur de la btk |
| US9995753B2 (en) | 2015-09-25 | 2018-06-12 | Merck Sharp & Dohme Corp. | Anti-pembrolizumab antibodies |
| EP3356416B1 (en) * | 2015-09-29 | 2021-03-24 | Shanghai Zhangjiang Biotechnology Co., Ltd | Pd-1 antibodies and uses thereof |
| WO2017055324A1 (en) | 2015-09-29 | 2017-04-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for quantifying the population of cells of monocytic origin in a tissue sample |
| WO2017055321A1 (en) | 2015-09-29 | 2017-04-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for quantifying the population of fibroblasts in a tissue sample |
| EP3356551B1 (en) | 2015-09-29 | 2020-09-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for determining the metabolic status of b-lymphomas |
| WO2017055327A1 (en) | 2015-09-29 | 2017-04-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for quantifying the population of endothelial cells in a tissue sample |
| EA201890790A1 (ru) * | 2015-09-29 | 2018-10-31 | Селджин Корпорейшн | Связывающие pd-1 белки и способы их применения |
| WO2017055325A1 (en) | 2015-09-29 | 2017-04-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for quantifying the population of nk cells in a tissue sample |
| WO2017055319A1 (en) | 2015-09-29 | 2017-04-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for quantifying the population of b cells in a tissue sample |
| WO2017055326A1 (en) | 2015-09-29 | 2017-04-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for quantifying the population of myeloid dendritic cells in a tissue sample |
| WO2017055320A1 (en) | 2015-09-29 | 2017-04-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for quantifying the population of cytotoxic lymphocytes in a tissue sample |
| WO2017055322A1 (en) | 2015-09-29 | 2017-04-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for quantifying the population of neutrophils in a tissue sample |
| KR20180053738A (ko) | 2015-09-30 | 2018-05-23 | 얀센 바이오테크 인코포레이티드 | 인간 cd40과 특이적으로 결합하는 길항적 항체 및 사용 방법 |
| EP3359573B1 (en) | 2015-10-01 | 2023-01-04 | The Whitehead Institute for Biomedical Research | Labeling of antibodies |
| EP3356413B1 (en) | 2015-10-01 | 2022-01-05 | Potenza Therapeutics, Inc. | Anti-tigit antigen-binding proteins and methods of use thereof |
| JP2018530550A (ja) | 2015-10-01 | 2018-10-18 | ギリアド サイエンシズ， インコーポレイテッド | 癌を治療するためのｂｔｋ阻害剤とチェックポイント阻害剤との組合せ |
| RU2746409C1 (ru) | 2015-10-02 | 2021-04-13 | Ф. Хоффманн-Ля Рош Аг | Антитела к pd1 и способы их применения |
| US12030942B2 (en) | 2015-10-02 | 2024-07-09 | Les Laboratoires Servier | Anti-PD-1 antibodies and compositions |
| PL3356411T3 (pl) | 2015-10-02 | 2021-12-06 | F. Hoffmann-La Roche Ag | Przeciwciała dwuswoiste swoiste dla PD1 i TIM3 |
| WO2017059902A1 (en) | 2015-10-07 | 2017-04-13 | Biontech Rna Pharmaceuticals Gmbh | 3' utr sequences for stabilization of rna |
| AU2016334041B2 (en) | 2015-10-08 | 2023-02-09 | Macrogenics, Inc. | Combination therapy for the treatment of cancer |
| WO2017060397A1 (en) | 2015-10-09 | 2017-04-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the survival time of subjects suffering from melanoma metastases |
| EP3362074B1 (en) | 2015-10-16 | 2023-08-09 | President and Fellows of Harvard College | Regulatory t cell pd-1 modulation for regulating t cell effector immune responses |
| WO2017066134A1 (en) | 2015-10-16 | 2017-04-20 | Merck Sharp & Dohme Corp. | Processes for preparing formulations for gastrointestinal-targeted therapies |
| EP3365062B1 (en) | 2015-10-19 | 2024-09-18 | CG Oncology, Inc. | Methods of treating solid or lymphatic tumors by combination therapy |
| CN105175544B (zh) * | 2015-10-20 | 2021-04-09 | 安徽瀚海博兴生物技术有限公司 | 一种抗pd-1人源化单克隆抗体及其应用 |
| CN105175545B (zh) * | 2015-10-20 | 2019-01-25 | 安徽瀚海博兴生物技术有限公司 | 一种抗vegf-抗pd-1双功能抗体及其应用 |
| US10149887B2 (en) | 2015-10-23 | 2018-12-11 | Canbas Co., Ltd. | Peptides and peptidomimetics in combination with t cell activating and/or checkpoint inhibiting agents for cancer treatment |
| MA44334A (fr) | 2015-10-29 | 2018-09-05 | Novartis Ag | Conjugués d'anticorps comprenant un agoniste du récepteur de type toll |
| JO3555B1 (ar) | 2015-10-29 | 2020-07-05 | Merck Sharp & Dohme | جسم مضاد يبطل فعالية فيروس الالتهاب الرئوي البشري |
| LT3370733T (lt) | 2015-11-02 | 2021-10-25 | Board Of Regents, The University Of Texas System | Cd40 aktyvinimo ir imuninės kontrolės taškų blokados būdai |
| KR20180069903A (ko) | 2015-11-02 | 2018-06-25 | 파이브 프라임 테라퓨틱스, 인크. | Cd80 세포외 도메인 폴리펩타이드 및 이들의 암 치료에서의 용도 |
| HUE057837T2 (hu) | 2015-11-03 | 2022-06-28 | Janssen Biotech Inc | PD-1-et specifikusan kötõ ellenanyagok és alkalmazásaik |
| SI3370770T1 (sl) | 2015-11-03 | 2021-03-31 | Janssen Biotech, Inc. | Subkutane formulacije protiteles proti CD38 in njihove uporabe |
| WO2017077382A1 (en) | 2015-11-06 | 2017-05-11 | Orionis Biosciences Nv | Bi-functional chimeric proteins and uses thereof |
| WO2017079746A2 (en) | 2015-11-07 | 2017-05-11 | Multivir Inc. | Methods and compositions comprising tumor suppressor gene therapy and immune checkpoint blockade for the treatment of cancer |
| US11072657B2 (en) | 2015-11-18 | 2021-07-27 | Bristol-Myers Squibb Company | Treatment of lung cancer using a combination of an anti-PD-1 antibody and an anti-CTLA-4 antibody |
| CN106699889A (zh) * | 2015-11-18 | 2017-05-24 | 礼进生物医药科技（上海）有限公司 | 抗pd-1抗体及其治疗用途 |
| WO2017091580A1 (en) | 2015-11-23 | 2017-06-01 | Five Prime Therapeutics, Inc. | Predicting response to cancer treatment with fgfr2 inhibitors |
| AU2016362774A1 (en) | 2015-12-01 | 2018-05-31 | Glaxosmithkline Intellectual Property Development Limited | Combination treatments and uses and methods thereof |
| US10858432B2 (en) | 2015-12-02 | 2020-12-08 | Stcube, Inc. | Antibodies specific to glycosylated PD-1 and methods of use thereof |
| WO2017093933A1 (en) | 2015-12-03 | 2017-06-08 | Glaxosmithkline Intellectual Property Development Limited | Cyclic purine dinucleotides as modulators of sting |
| WO2017098421A1 (en) | 2015-12-08 | 2017-06-15 | Glaxosmithkline Intellectual Property Development Limited | Benzothiadiazine compounds |
| EP3387442A4 (en) * | 2015-12-09 | 2019-05-08 | Corvus Pharmaceuticals, Inc. | HUMANIZED ANTI-CD73 ANTIBODIES |
| CR20180318A (es) | 2015-12-14 | 2018-09-19 | Macrogenics Inc | Moléculas biespecíficas que tienen inmunorreactividad con pd-1 y ctla-4, y métodos de uso de las mismas |
| US10538497B2 (en) | 2015-12-15 | 2020-01-21 | Merck Sharp & Dohme Corp. | Compounds as indoleamine 2,3-dioxygenase inhibitors |
| EP4424322A3 (en) | 2015-12-17 | 2025-04-16 | Novartis AG | Antibody molecules to pd-1 and uses thereof |
| US10392442B2 (en) | 2015-12-17 | 2019-08-27 | Bristol-Myers Squibb Company | Use of anti-PD-1 antibody in combination with anti-CD27 antibody in cancer treatment |
| GB201522311D0 (en) | 2015-12-17 | 2016-02-03 | Photocure Asa | Use |
| GB201522309D0 (en) | 2015-12-17 | 2016-02-03 | Photocure Asa | Use |
| US11091556B2 (en) | 2015-12-18 | 2021-08-17 | Intervet Inc. | Caninized human antibodies to human IL-4R alpha |
| CA3008102A1 (en) | 2015-12-18 | 2017-06-22 | Novartis Ag | Antibodies targeting cd32b and methods of use thereof |
| FI3390451T3 (fi) | 2015-12-18 | 2025-03-28 | Intervet Int Bv | Kaninisoidut ihmisen vasta-aineet ihmisen ja koiraeläimen il-4r alfaa kohtaan |
| WO2017106630A1 (en) | 2015-12-18 | 2017-06-22 | The General Hospital Corporation | Polyacetal polymers, conjugates, particles and uses thereof |
| SG10202005790VA (en) | 2015-12-22 | 2020-07-29 | Incyte Corp | Heterocyclic compounds as immunomodulators |
| MA44140A (fr) | 2015-12-22 | 2021-05-19 | Dana Farber Cancer Inst Inc | Récepteur d'antigène chimérique (car) contre la mésothéline et anticorps contre l'inhibiteur de pd-l1 pour une utilisation combinée dans une thérapie anticancéreuse |
| KR20180089444A (ko) | 2015-12-22 | 2018-08-08 | 리제너론 파아마슈티컬스, 인크. | 암을 치료하기 위한 항-pd-1 항체와 이특이적 항-cd20/항-cd3 항체의 조합 |
| SMT202200310T1 (it) | 2015-12-23 | 2022-09-14 | Modernatx Inc | Metodi di utilizzo dei polinucleotidi codificanti il ligando di ox40 |
| WO2017118634A1 (en) | 2016-01-04 | 2017-07-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of pd-1 and tim-3 as a measure for cd8+ cells in predicting and treating renal cell carcinoma |
| BR112018013761A2 (pt) | 2016-01-08 | 2018-12-11 | Celgene Corp | compostos antiproliferativos e suas composições farmacêuticas e usos |
| SG11201805777QA (en) | 2016-01-08 | 2018-08-30 | Celgene Corp | Formulations of 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide |
| AU2017206039B2 (en) | 2016-01-08 | 2021-03-25 | Celgene Corporation | Solid forms of 2-(4-chlorophenyl)-N-((2-2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl) methyl)-2,2-difluoroacetamide, and their pharmaceutical compositions and uses |
| MX2018008383A (es) | 2016-01-10 | 2019-05-30 | Neotx Therapeutics Ltd | Inmunoterapia contra el cáncer mediada por superantígeno mejorada por inmunopotenciador. |
| IL260218B2 (en) | 2016-01-11 | 2023-04-01 | Novartis Ag | Humanized monoclonal antibodies that elicit an immune response against interleukin-2, and their fusion proteins |
| US20190008869A1 (en) | 2016-01-13 | 2019-01-10 | Acerta Pharma B.V. | Therapeutic Combinations of an Antifolate and a BTK Inhibitor |
| US10759859B2 (en) | 2016-01-14 | 2020-09-01 | Bps Bioscience, Inc. | Anti-PD-1 antibodies and uses thereof |
| SG11201805831RA (en) | 2016-01-21 | 2018-08-30 | Innate Pharma | Neutralization of inhibitory pathways in lymphocytes |
| EP3405497A2 (en) | 2016-01-22 | 2018-11-28 | Mabquest SA | Immunological reagents |
| US11214617B2 (en) | 2016-01-22 | 2022-01-04 | MabQuest SA | Immunological reagents |
| EP3407912B1 (en) | 2016-01-28 | 2022-05-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for enhancing the potency of the immune checkpoint inhibitors |
| US10918737B2 (en) | 2016-01-28 | 2021-02-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical composition for the treatment of cancer |
| WO2017129763A1 (en) | 2016-01-28 | 2017-08-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of signet ring cell gastric cancer |
| WO2017132827A1 (en) | 2016-02-02 | 2017-08-10 | Innovent Biologics (Suzhou) Co., Ltd. | Pd-1 antibodies |
| EP3411407B1 (en) | 2016-02-05 | 2024-04-03 | Orionis Biosciences BV | Bispecific signaling agents and uses thereof |
| CA3012294A1 (en) | 2016-02-17 | 2017-08-24 | Novartis Ag | Tgfbeta 2 antibodies |
| JOP20170045B1 (ar) | 2016-02-19 | 2021-08-17 | Novartis Ag | مركبات بيريدون رباعية الحلقة كمضادات فيروسية |
| CN109312347A (zh) | 2016-02-19 | 2019-02-05 | 希望之城 | 双特异性适配子 |
| CA3013333A1 (en) | 2016-02-26 | 2017-08-31 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Antibodies having specificity for btla and uses thereof |
| CN109476731A (zh) | 2016-02-29 | 2019-03-15 | 基础医药有限公司 | 治疗癌症的方法 |
| AU2017225854B2 (en) | 2016-02-29 | 2020-11-19 | Foundation Medicine, Inc. | Therapeutic and diagnostic methods for cancer |
| EP3423482A1 (en) | 2016-03-04 | 2019-01-09 | Novartis AG | Cells expressing multiple chimeric antigen receptor (car) molecules and uses therefore |
| EP3426688A1 (en) | 2016-03-08 | 2019-01-16 | Innate Pharma | Siglec neutralizing antibodies |
| WO2017153952A1 (en) | 2016-03-10 | 2017-09-14 | Glaxosmithkline Intellectual Property Development Limited | 5-sulfamoyl-2-hydroxybenzamide derivatives |
| WO2017156349A1 (en) | 2016-03-10 | 2017-09-14 | Cold Genesys, Inc. | Methods of treating solid or lymphatic tumors by combination therapy |
| WO2017160599A1 (en) | 2016-03-14 | 2017-09-21 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Use of cd300b antagonists to treat sepsis and septic shock |
| CN109310885B (zh) | 2016-03-15 | 2022-05-31 | 梅尔莎纳医疗公司 | NaPi2b靶向抗体-药物缀合物及其使用方法 |
| ES2977541T3 (es) | 2016-03-16 | 2024-08-26 | Amal Therapeutics Sa | Combinación de modulador de puntos de control inmunitarios y complejo que comprende un péptido de penetracióncelular, una molécula de carga y un agonista peptídico de TLR para su uso en medicina |
| JP2019512271A (ja) | 2016-03-21 | 2019-05-16 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | Ｔ細胞疲弊状態特異的遺伝子発現調節因子およびその使用 |
| WO2017163186A1 (en) | 2016-03-24 | 2017-09-28 | Novartis Ag | Alkynyl nucleoside analogs as inhibitors of human rhinovirus |
| EP3433275A1 (en) | 2016-03-24 | 2019-01-30 | Millennium Pharmaceuticals, Inc. | Methods of treating gastrointestinal immune-related adverse events in immune oncology treatments |
| WO2017165742A1 (en) | 2016-03-24 | 2017-09-28 | Millennium Pharmaceuticals, Inc. | Methods of treating gastrointestinal immune-related adverse events in anti-ctla4 anti-pd-1 combination treatments |
| ES2973870T3 (es) | 2016-03-29 | 2024-06-24 | Univ Texas | Anticuerpos de función doble específicos para PD-L1 glucosilado y métodos de uso de los mismos |
| WO2017172517A1 (en) | 2016-03-29 | 2017-10-05 | Stcube & Co., Inc. | Methods for selecting antibodies that specifically bind glycosylated immune checkpoint proteins |
| KR20230148844A (ko) | 2016-03-29 | 2023-10-25 | 유니버시티 오브 써던 캘리포니아 | 암을 표적하는 키메라 항원 수용체 |
| EP3436480A4 (en) | 2016-03-30 | 2019-11-27 | Musc Foundation for Research Development | METHOD FOR THE TREATMENT AND DIAGNOSIS OF CANCER BY TARGETING GLYCOPROTEIN A REPETITION PREDOMINANT (GARP) AND FOR EFFECTIVE IMMUNOTHERAPY ALONE OR IN COMBINATION |
| EP3225253A1 (en) | 2016-04-01 | 2017-10-04 | Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts | Cancer therapy with an oncolytic virus combined with a checkpoint inhibitor |
| WO2017176925A1 (en) | 2016-04-05 | 2017-10-12 | Bristol-Myers Squibb Company | Cytokine profiling analysis for predicting prognosis of a patient in need of an anti-cancer treatment |
| WO2017176965A1 (en) | 2016-04-07 | 2017-10-12 | Chemocentryx, Inc. | Reducing tumor burden by administering ccr1 antagonists in combination with pd-1 inhibitors or pd-l1 inhibitors |
| ES2781474T3 (es) | 2016-04-07 | 2020-09-02 | Glaxosmithkline Ip Dev Ltd | Amidas heterocíclicas útiles como moduladores de proteínas |
| SG10201900628RA (en) | 2016-04-07 | 2019-02-27 | Glaxosmithkline Ip Dev Ltd | Heterocyclic amides useful as protein modulators |
| AU2017249698B2 (en) | 2016-04-13 | 2023-03-09 | Vivia Biotech, S.L | Ex vivo bite-activated T cells |
| US11414497B2 (en) | 2016-04-13 | 2022-08-16 | Orimabs Ltd. | Anti-PSMA antibodies and use thereof |
| JP7015237B2 (ja) | 2016-04-28 | 2022-02-02 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 腫瘍の成長を抑制する方法 |
| EP3449017B1 (en) | 2016-04-29 | 2021-12-22 | Board of Regents, The University of Texas System | Targeted measure of transcriptional activity related to hormone receptors |
| AU2017257189B2 (en) | 2016-04-29 | 2022-03-31 | Icahn School Of Medicine At Mount Sinai | Targeting the innate immune system to induce long-term tolerance and to resolve macrophage accumulation in atherosclerosis |
| US20190298824A1 (en) | 2016-05-04 | 2019-10-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv | Albumin-binding immunomodulatory compositions and methods of use thereof |
| CN109328188A (zh) | 2016-05-05 | 2019-02-12 | 葛兰素史密斯克莱知识产权（第2 号）有限公司 | Zeste增强子同源物2抑制剂 |
| EP3243832A1 (en) | 2016-05-13 | 2017-11-15 | F. Hoffmann-La Roche AG | Antigen binding molecules comprising a tnf family ligand trimer and pd1 binding moiety |
| WO2017194783A1 (en) | 2016-05-13 | 2017-11-16 | Orionis Biosciences Nv | Targeted mutant interferon-beta and uses thereof |
| TWI822521B (zh) | 2016-05-13 | 2023-11-11 | 美商再生元醫藥公司 | 藉由投予pd-1抑制劑治療皮膚癌之方法 |
| US11753463B2 (en) | 2016-05-13 | 2023-09-12 | Orionis Biosciences BV | Therapeutic targeting of non-cellular structures |
| MX393869B (es) | 2016-05-18 | 2025-03-24 | Modernatx Inc | Polinucleotidos que codifican interleucina-12 (il12) y usos de los mismos. |
| CA3024917A1 (en) | 2016-05-18 | 2017-11-23 | Modernatx, Inc. | Combinations of mrnas encoding immune modulating polypeptides and uses thereof |
| EP3458092A1 (en) | 2016-05-18 | 2019-03-27 | Modernatx, Inc. | Mrna combination therapy for the treatment of cancer |
| CN105968200B (zh) | 2016-05-20 | 2019-03-15 | 瑞阳(苏州)生物科技有限公司 | 抗人pd-l1人源化单克隆抗体及其应用 |
| US10688104B2 (en) | 2016-05-20 | 2020-06-23 | Eli Lilly And Company | Combination therapy with Notch and PD-1 or PD-L1 inhibitors |
| WO2017201502A1 (en) | 2016-05-20 | 2017-11-23 | Biohaven Pharmaceutical Holding Company Ltd. | Use of glutamate modulating agents with immunotherapies to treat cancer |
| US11623958B2 (en) | 2016-05-20 | 2023-04-11 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
| WO2017205216A1 (en) | 2016-05-23 | 2017-11-30 | Eli Lilly And Company | Combination of pembrolizumab and abemaciclib for the treatment of cancer |
| CN106008714B (zh) * | 2016-05-24 | 2019-03-15 | 瑞阳(苏州)生物科技有限公司 | 抗人pd-1人源化单克隆抗体及其应用 |
| WO2017202962A1 (en) | 2016-05-24 | 2017-11-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of non small cell lung cancer (nsclc) that coexists with chronic obstructive pulmonary disease (copd) |
| CN109689089A (zh) | 2016-05-25 | 2019-04-26 | 国家医疗保健研究所 | 治疗癌症的方法和组合物 |
| MY195089A (en) | 2016-05-27 | 2023-01-10 | Agenus Inc | Anti-Tim-3 Antibodies and Methods of use thereof |
| EP3463405A4 (en) | 2016-05-27 | 2020-02-26 | DNAtrix, Inc. | Adenovirus and immunomodulator combination therapy |
| SG11201810454YA (en) | 2016-06-02 | 2018-12-28 | Bristol Myers Squibb Co | Use of an anti-pd-1 antibody in combination with an anti-cd30 antibody in lymphoma treatment |
| EP3463457B1 (en) | 2016-06-02 | 2023-06-28 | Bristol-Myers Squibb Company | Pd-1 blockade with nivolumab in refractory hodgkin's lymphoma |
| EP4386005A3 (en) | 2016-06-03 | 2024-09-04 | Bristol-Myers Squibb Company | Anti-pd-1 antibody for use in a method of treatment of recurrent small cell lung cancer |
| KR20230118713A (ko) | 2016-06-03 | 2023-08-11 | 브리스톨-마이어스 스큅 컴퍼니 | 종양을 치료하는 방법에 사용하기 위한 항-pd-1 항체 |
| KR102515509B1 (ko) | 2016-06-03 | 2023-03-28 | 브리스톨-마이어스 스큅 컴퍼니 | 결장직장암을 갖는 환자의 치료에서의 항-pd-1 항체의 용도 |
| WO2017210119A1 (en) | 2016-06-03 | 2017-12-07 | Imclone Llc | Combination of ramucirumab and pembrolizumab for the treatment of certain cancers |
| GB201609811D0 (en) | 2016-06-05 | 2016-07-20 | Snipr Technologies Ltd | Methods, cells, systems, arrays, RNA and kits |
| BR112018075615A2 (pt) | 2016-06-08 | 2019-07-02 | Glaxosmithkline Ip Dev Ltd | compostos químicos |
| CA3026982A1 (en) | 2016-06-08 | 2017-12-14 | Glaxosmithkline Intellectual Property Development Limited | Chemical compounds as atf4 pathway inhibitors |
| SG11201811003PA (en) * | 2016-06-13 | 2019-01-30 | I Mab | Anti-pd-l1 antibodies and uses thereof |
| EP3468586B1 (en) * | 2016-06-14 | 2024-08-07 | Xencor, Inc. | Bispecific checkpoint inhibitor antibodies |
| ES2820502T3 (es) | 2016-06-14 | 2021-04-21 | Novartis Ag | Forma cristalina de (R)-4-(5-(ciclopropiletilinil)isoxazol-3-il)-N-hidroxi-2-metil-2-(metilsulfonil)butanamida como agente antibacteriano |
| WO2017216686A1 (en) | 2016-06-16 | 2017-12-21 | Novartis Ag | 8,9-fused 2-oxo-6,7-dihydropyrido-isoquinoline compounds as antivirals |
| WO2017216685A1 (en) | 2016-06-16 | 2017-12-21 | Novartis Ag | Pentacyclic pyridone compounds as antivirals |
| JP7461741B2 (ja) | 2016-06-20 | 2024-04-04 | カイマブ・リミテッド | 抗ｐｄ－ｌ１およびｉｌ－２サイトカイン |
| BR112018076534A2 (pt) | 2016-06-20 | 2019-04-02 | Incyte Corporation | compostos heterocíclicos como imunomoduladores |
| AU2017281797A1 (en) | 2016-06-24 | 2019-01-24 | Infinity Pharmaceuticals, Inc. | Combination therapies |
| CN109475536B (zh) | 2016-07-05 | 2022-05-27 | 百济神州有限公司 | 用于治疗癌症的PD-l拮抗剂和RAF抑制剂的组合 |
| US11098077B2 (en) | 2016-07-05 | 2021-08-24 | Chinook Therapeutics, Inc. | Locked nucleic acid cyclic dinucleotide compounds and uses thereof |
| WO2018011166A2 (en) | 2016-07-12 | 2018-01-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for quantifying the population of myeloid dendritic cells in a tissue sample |
| RU2656181C1 (ru) * | 2016-07-13 | 2018-05-31 | Закрытое Акционерное Общество "Биокад" | Анти-pd-1-антитела, способ их получения и способ применения |
| KR102565885B1 (ko) | 2016-07-20 | 2023-08-09 | 유니버시티 오브 유타 리서치 파운데이션 | Cd229 car t 세포 및 이의 사용 방법 |
| WO2018014260A1 (en) | 2016-07-20 | 2018-01-25 | Nanjing Legend Biotech Co., Ltd. | Multispecific antigen binding proteins and methods of use thereof |
| EP3487883B1 (en) | 2016-07-20 | 2023-01-04 | Stcube, Inc. | Methods of cancer treatment and therapy using a combination of antibodies that bind glycosylated pd-l1 |
| CA3031047A1 (en) | 2016-07-20 | 2018-01-25 | Glaxosmithkline Intellectual Property Development Limited | Isoquinoline derivatives as perk inhibitors |
| AU2017302668B9 (en) * | 2016-07-28 | 2023-06-22 | Novartis Ag | Combination therapies of chimeric antigen receptors and PD-1 inhibitors |
| NL2017267B1 (en) | 2016-07-29 | 2018-02-01 | Aduro Biotech Holdings Europe B V | Anti-pd-1 antibodies |
| CN109562282A (zh) | 2016-07-29 | 2019-04-02 | 伊莱利利公司 | 用于治疗癌症的使用merestinib和抗-pd-l1或抗-pd-1抑制剂的组合疗法 |
| WO2018026606A1 (en) | 2016-08-01 | 2018-02-08 | Threshold Pharmaceuticals, Inc. | Administration of hypoxia activated prodrugs in combination with immune modulatory agents for treating cancer |
| CN107686520B (zh) * | 2016-08-04 | 2023-01-03 | 信达生物制药(苏州)有限公司 | 抗pd-l1纳米抗体及其应用 |
| WO2018025221A1 (en) | 2016-08-04 | 2018-02-08 | Glaxosmithkline Intellectual Property Development Limited | Anti-icos and anti-pd-1 antibody combination therapy |
| MY189412A (en) | 2016-08-05 | 2022-02-10 | Y Biologics Inc | Antibody to programmed cell death 1 (pd-1) and use thereof |
| WO2018029336A1 (en) | 2016-08-12 | 2018-02-15 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for determining whether a subject was administered with an activator of the ppar beta/delta pathway. |
| CA3034326A1 (en) | 2016-08-19 | 2018-02-22 | Beigene, Ltd. | Use of a combination comprising a btk inhibitor for treating cancers |
| EP4342978A3 (en) | 2016-09-01 | 2024-07-03 | Chimera Bioengineering Inc. | Gold optimized car t-cells |
| WO2018049014A1 (en) | 2016-09-07 | 2018-03-15 | Trustees Of Tufts College | Dash inhibitors, and uses related thereto |
| EA201990374A1 (ru) | 2016-09-09 | 2019-09-30 | Тг Терапьютикс, Инк. | Комбинация антитела против cd20, ингибитора pi3-киназы-дельта и антитела против pd-1 или против pd-l1 для лечения гематологических раков |
| US20190218294A1 (en) | 2016-09-09 | 2019-07-18 | Bristol-Myers Squibb Company | Use of an anti-pd-1 antibody in combination with an anti-mesothelin antibody in cancer treatment |
| TW201811788A (zh) | 2016-09-09 | 2018-04-01 | 瑞士商諾華公司 | 作為抗病毒劑之多環吡啶酮化合物 |
| WO2018046736A1 (en) | 2016-09-12 | 2018-03-15 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the survival time of patients suffering from cancer |
| WO2018046738A1 (en) | 2016-09-12 | 2018-03-15 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the survival time of patients suffering from cancer |
| IL306104A (en) | 2016-09-14 | 2023-11-01 | Abbvie Biotherapeutics Inc | Antibodies against (CD27) PD-1 |
| CN109952316A (zh) * | 2016-09-14 | 2019-06-28 | 北京韩美药品有限公司 | 一种能够特异性地结合pd-1的抗体及其功能片段 |
| WO2018053401A1 (en) | 2016-09-19 | 2018-03-22 | Celgene Corporation | Methods of treating vitiligo using pd-1 binding proteins |
| JP2019531284A (ja) | 2016-09-19 | 2019-10-31 | セルジーン コーポレイション | Ｐｄ−１結合タンパク質を使用して免疫障害を治療する方法 |
| WO2018057585A1 (en) | 2016-09-21 | 2018-03-29 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chimeric antigen receptor (car) that targets chemokine receptor ccr4 and its use |
| IL265479B (en) | 2016-09-21 | 2022-09-01 | Amal Therapeutics Sa | A fusion containing a cell-penetrating peptide, a multiple epitope, and a peptide tlr agonist for cancer therapy |
| US20200016177A1 (en) | 2016-09-22 | 2020-01-16 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and pharmaceutical compositions for reprograming immune environment in a subject in need thereof |
| US11673971B2 (en) | 2016-09-23 | 2023-06-13 | Marengo Therapeutics, Inc. | Multispecific antibody molecules comprising lambda and kappa light chains |
| WO2018057303A1 (en) | 2016-09-26 | 2018-03-29 | Imclone Llc | Combination therapy for cancer |
| AU2017335732B2 (en) | 2016-09-27 | 2024-11-21 | Board Of Regents, The University Of Texas System | Methods for enhancing immune checkpoint blockade therapy by modulating the microbiome |
| JOP20190061A1 (ar) | 2016-09-28 | 2019-03-26 | Novartis Ag | مثبطات بيتا-لاكتاماز |
| BR112019006074A2 (pt) | 2016-09-29 | 2019-06-18 | Beijing Hanmi Pharmaceutical Co., Ltd. | heterodímero, método de produção do heterodímero, métodos de produção de um heterodímero, ácido nucleico, vetor ou sistema de vetores, célula, composição farmacêutica e método de tratamento ou prevenção de uma doença ou distúrbio em um sujeito em necessidade do mesmo |
| SG10202008647TA (en) | 2016-10-04 | 2020-10-29 | Merck Sharp & Dohme | BENZO[b]THIOPHENE COMPOUNDS AS STING AGONISTS |
| IL265762B2 (en) | 2016-10-06 | 2024-04-01 | Merck Patent Gmbh | Dosing regimen of avelumab for the treatment of cancer |
| MX2019003934A (es) | 2016-10-06 | 2019-07-10 | Genentech Inc | Métodos terapéuticos y de diagnóstico para el cáncer. |
| CN110049774A (zh) | 2016-10-07 | 2019-07-23 | 恩特罗姆公司 | 肿瘤相关抗原表位的小型生物群序列变体 |
| IL296165B2 (en) | 2016-10-07 | 2023-10-01 | Enterome S A | Immunogenic compounds for cancer treatment |
| SG10201913823VA (en) | 2016-10-07 | 2020-03-30 | Novartis Ag | Chimeric antigen receptors for the treatment of cancer |
| US11478538B2 (en) | 2016-10-07 | 2022-10-25 | Enterome S.A. | Immunogenic compounds for cancer therapy |
| WO2018070069A1 (ja) | 2016-10-11 | 2018-04-19 | サイトリミック株式会社 | 医薬 |
| IL265800B2 (en) | 2016-10-11 | 2023-10-01 | Agenus Inc | Anti-LAG-3 antibodies and methods of using them |
| WO2018068201A1 (en) * | 2016-10-11 | 2018-04-19 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies and variants thereof against ctla-4 |
| CN110072540B (zh) | 2016-10-12 | 2023-06-02 | 得克萨斯州大学系统董事会 | 用于tusc2免疫治疗的方法和组合物 |
| SG11201902974PA (en) | 2016-10-14 | 2019-05-30 | Merck Sharp & Dohme | Combination of a pd-1 antagonist and eribulin for treating urothelial cancer |
| WO2018071576A1 (en) | 2016-10-14 | 2018-04-19 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Treatment of tumors by inhibition of cd300f |
| BR112018013653B1 (pt) * | 2016-10-15 | 2020-12-15 | Innovent Biologics (Suzhou) Co., Ltd | Anticorpos anti-pd-1, processo para produção do mesmo e uso dos anticorpos |
| WO2018073753A1 (en) | 2016-10-18 | 2018-04-26 | Novartis Ag | Fused tetracyclic pyridone compounds as antivirals |
| WO2018075447A1 (en) | 2016-10-19 | 2018-04-26 | The Trustees Of Columbia University In The City Of New York | Combination of braf inhibitor, talimogene laherparepvec, and immune checkpoint inhibitor for use in the treatment cancer (melanoma) |
| EP3529264B1 (en) | 2016-10-24 | 2022-03-09 | Orionis Biosciences BV | Targeted mutant interferon-gamma and uses thereof |
| US20190315865A1 (en) | 2016-10-28 | 2019-10-17 | Bristol-Myers Squibb Company | Methods of treating urothelial carcinoma using an anti-pd-1 antibody |
| TWI788307B (zh) | 2016-10-31 | 2023-01-01 | 美商艾歐凡斯生物治療公司 | 用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞 |
| EP3689419A1 (en) | 2016-11-01 | 2020-08-05 | AnaptysBio, Inc. | Antibodies directed against t cell immunoglobulin and mucin protein 3 (tim-3) |
| WO2018085468A1 (en) | 2016-11-01 | 2018-05-11 | Anaptysbio, Inc. | Antibodies directed against programmed death- 1 (pd-1) |
| WO2018083087A2 (en) | 2016-11-02 | 2018-05-11 | Glaxosmithkline Intellectual Property (No.2) Limited | Binding proteins |
| KR102687833B1 (ko) | 2016-11-02 | 2024-07-24 | 브리스톨-마이어스 스큅 컴퍼니 | 다발성 골수종 치료를 위한 bcma 및 cd3에 대응하는 이중 특이적 항체 및 면역학적 약물의 복합용도 |
| JP7086066B2 (ja) | 2016-11-02 | 2022-06-17 | ジョンス セラピューティクス， インコーポレイテッド | Ｐｄ－１に対する抗体及びその使用 |
| JP7039582B2 (ja) | 2016-11-03 | 2022-03-22 | ブリストル－マイヤーズ スクイブ カンパニー | 活性化可能な抗ｃｔｌａ－４抗体およびその使用 |
| US10342785B2 (en) | 2016-11-04 | 2019-07-09 | Askat Inc. | Use of EP4 receptor antagonists for the treatment of NASH-associated liver cancer |
| JP2019534044A (ja) | 2016-11-08 | 2019-11-28 | クイル ピュージェット サウンド バイオセラピューティクス コーポレーション | 抗ｐｄ１および抗ｃｔｌａ４抗体 |
| WO2018089423A1 (en) | 2016-11-09 | 2018-05-17 | Musc Foundation For Research Development | Cd38-nad+ regulated metabolic axis in anti-tumor immunotherapy |
| JP7750644B2 (ja) * | 2016-11-09 | 2025-10-07 | エンジーン，インコーポレイティド | プログラム細胞死リガンド１の腸管発現 |
| US20190345500A1 (en) | 2016-11-14 | 2019-11-14 | |Nserm (Institut National De La Santé Et De La Recherche Médicale) | Methods and pharmaceutical compositions for modulating stem cells proliferation or differentiation |
| WO2018094225A1 (en) | 2016-11-17 | 2018-05-24 | Board Of Regents, The University Of Texas System | Compounds with anti-tumor activity against cancer cells bearing egfr or her2 exon 20 mutations |
| TN2019000161A1 (en) * | 2016-11-18 | 2020-10-05 | Beijing Hanmi Pharmaceutical Co Ltd | Anti-pd-1/anti-her2 natural antibody structure-like bispecific antibody of heterodimeric form and preparation thereof |
| CN110214153B (zh) * | 2016-11-18 | 2024-03-29 | 法国施维雅药厂 | 抗pd-1抗体及组合物 |
| WO2018094275A1 (en) | 2016-11-18 | 2018-05-24 | Tolero Pharmaceuticals, Inc. | Alvocidib prodrugs and their use as protein kinase inhibitors |
| EP3541825A1 (en) | 2016-11-21 | 2019-09-25 | Idenix Pharmaceuticals LLC. | Cyclic phosphate substituted nucleoside derivatives for the treatment of liver diseases |
| WO2018098352A2 (en) | 2016-11-22 | 2018-05-31 | Jun Oishi | Targeting kras induced immune checkpoint expression |
| US11135307B2 (en) | 2016-11-23 | 2021-10-05 | Mersana Therapeutics, Inc. | Peptide-containing linkers for antibody-drug conjugates |
| CA3045306A1 (en) | 2016-11-29 | 2018-06-07 | Boston Biomedical, Inc. | Naphthofuran derivatives, preparation, and methods of use thereof |
| WO2018099539A1 (en) | 2016-11-29 | 2018-06-07 | Horst Lindhofer | Combination of t-cell redirecting multifunctional antibodies with immune checkpoint modulators and uses thereof |
| TW201825119A (zh) | 2016-11-30 | 2018-07-16 | 日商協和醱酵麒麟有限公司 | 使用抗ccr4抗體及抗pd-1抗體治療癌症之方法 |
| BR112019011350A2 (pt) | 2016-12-01 | 2019-10-22 | Glaxosmithkline Ip Dev Ltd | terapia de combinação |
| AU2017368923A1 (en) | 2016-12-01 | 2019-06-13 | Glaxosmithkline Intellectual Property Development Limited | Combination therapy |
| KR20230156808A (ko) | 2016-12-03 | 2023-11-14 | 주노 쎄러퓨티크스 인코퍼레이티드 | Car-t 세포의 조절 방법 |
| WO2018106738A1 (en) | 2016-12-05 | 2018-06-14 | Massachusetts Institute Of Technology | Brush-arm star polymers, conjugates and particles, and uses thereof |
| WO2018106864A1 (en) | 2016-12-07 | 2018-06-14 | Agenus Inc. | Antibodies and methods of use thereof |
| PT3551660T (pt) | 2016-12-07 | 2023-11-30 | Ludwig Inst For Cancer Res Ltd | Anticorpos anti-ctla-4 e métodos de uso dos mesmos |
| JP7246309B2 (ja) | 2016-12-08 | 2023-03-27 | リクスト・バイオテクノロジー，インコーポレイテッド | 免疫応答を調節するためのオキサビシクロヘプタン |
| SG10201912575RA (en) | 2016-12-12 | 2020-02-27 | Daiichi Sankyo Co Ltd | Combination of antibody-drug conjugate and immune checkpoint inhibitor |
| EP3551226A1 (en) | 2016-12-12 | 2019-10-16 | MultiVir Inc. | Methods and compositions comprising viral gene therapy and an immune checkpoint inhibitor for treatment and prevention of cancer and infectious diseases |
| WO2018112360A1 (en) | 2016-12-16 | 2018-06-21 | Evelo Biosciences, Inc. | Combination therapies for treating cancer |
| WO2018112364A1 (en) | 2016-12-16 | 2018-06-21 | Evelo Biosciences, Inc. | Combination therapies for treating melanoma |
| EP3558963B1 (en) | 2016-12-22 | 2022-03-23 | Incyte Corporation | Bicyclic heteroaromatic compounds as immunomodulators |
| EP3558985B1 (en) | 2016-12-22 | 2022-09-07 | Incyte Corporation | Benzooxazole derivatives as immunomodulators |
| CN106519034B (zh) * | 2016-12-22 | 2020-09-18 | 鲁南制药集团股份有限公司 | 抗pd-1抗体及其用途 |
| EP3558377A1 (en) | 2016-12-23 | 2019-10-30 | Virttu Biologics Limited | Treatment of cancer |
| US11248049B2 (en) | 2016-12-23 | 2022-02-15 | Remd Biotherapeutics, Inc. | Immunotherapy using antibodies that bind Programmed Death 1 (PD-1) |
| CN107043420B (zh) * | 2016-12-26 | 2018-07-31 | 中国科学院微生物研究所 | 一种抗pd-1抗体及其应用 |
| WO2018122245A1 (en) | 2016-12-28 | 2018-07-05 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of predicting the survival time of patients suffering from cms3 colorectal cancer |
| WO2018122249A1 (en) | 2016-12-28 | 2018-07-05 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the survival time of patients suffering from a microsatellite stable colorectal cancer |
| FI3565844T3 (fi) | 2017-01-09 | 2023-05-09 | Tesaro Inc | Menetelmiä syövän hoitamiseksi anti-pd-1 -vasta-aineilla |
| ES2914123T3 (es) | 2017-01-09 | 2022-06-07 | Shuttle Pharmaceuticals Inc | Inhibidores selectivos de la histona desacetilasa para el tratamiento de una enfermedad humana |
| MA47206A (fr) | 2017-01-09 | 2019-11-13 | Tesaro Inc | Méthodes de traitement du cancer au moyen d'anticorps anti-tim-3 |
| US11584733B2 (en) | 2017-01-09 | 2023-02-21 | Shuttle Pharmaceuticals, Inc. | Selective histone deacetylase inhibitors for the treatment of human disease |
| US12473343B2 (en) | 2017-01-10 | 2025-11-18 | The General Hospital Corporation | Targeted t cells with cytotoxicity toward immunosuppressive cells |
| AU2018207172B2 (en) | 2017-01-13 | 2023-10-12 | Mink Therapeutics, Inc. | T cell receptors that bind to NY-ESO-1 and methods of use thereof |
| WO2018134279A1 (en) | 2017-01-18 | 2018-07-26 | Pieris Pharmaceuticals Gmbh | Novel fusion polypeptides specific for lag-3 and pd-1 |
| CN117586401A (zh) * | 2017-01-20 | 2024-02-23 | 大有华夏生物医药集团有限公司 | 抗pd-1抗体及其用途 |
| WO2018134784A1 (en) | 2017-01-20 | 2018-07-26 | Novartis Ag | Combination therapy for the treatment of cancer |
| CN108341871A (zh) * | 2017-01-24 | 2018-07-31 | 三生国健药业（上海）股份有限公司 | 抗pd-1单克隆抗体及其制备方法和应用 |
| WO2018137681A1 (en) | 2017-01-25 | 2018-08-02 | Beigene, Ltd. | Crystalline forms of (s) -7- (1- (but-2-ynoyl) piperidin-4-yl) -2- (4-phenoxyphenyl) -4, 5, 6, 7-tetrahy dropyrazolo [1, 5-a] pyrimidine-3-carboxamide, preparation, and uses thereof |
| JP7062010B2 (ja) | 2017-01-27 | 2022-05-02 | セルジーン コーポレイション | ３－（１－オキソ－４－（（４－（（３－オキソモルホリノ）メチル）ベンジル）オキシ）イソインドリン－２－イル）ピペリジン－２，６－ジオン及びそのアイソトポログ |
| JOP20190187A1 (ar) | 2017-02-03 | 2019-08-01 | Novartis Ag | مترافقات عقار جسم مضاد لـ ccr7 |
| EP3576765B1 (en) | 2017-02-06 | 2025-07-16 | Orionis Biosciences, Inc. | Targeted engineered interferon and uses thereof |
| MX2019009255A (es) | 2017-02-06 | 2019-11-05 | Orionis Biosciences Nv | Proteínas quiméricas dirigidas y sus usos. |
| WO2018146148A1 (en) | 2017-02-07 | 2018-08-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A method for predicting the response to checkpoint blockade cancer immunotherapy |
| WO2018146128A1 (en) | 2017-02-07 | 2018-08-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Detection of kit polymorphism for predicting the response to checkpoint blockade cancer immunotherapy |
| CN110290808B (zh) | 2017-02-10 | 2023-07-11 | 诺华股份有限公司 | 1-(4-氨基-5-溴-6-(1h-吡唑-1-基)嘧啶-2-基)-1h-吡唑-4-醇及其在治疗癌症中的用途 |
| WO2018150326A1 (en) | 2017-02-15 | 2018-08-23 | Glaxosmithkline Intellectual Property Development Limited | Combination treatment for cancer |
| WO2018151820A1 (en) | 2017-02-16 | 2018-08-23 | Elstar Therapeutics, Inc. | Multifunctional molecules comprising a trimeric ligand and uses thereof |
| TWI674261B (zh) | 2017-02-17 | 2019-10-11 | 美商英能腫瘤免疫股份有限公司 | Nlrp3 調節劑 |
| CA3054289A1 (en) | 2017-02-21 | 2018-08-30 | Regeneron Pharmaceuticals, Inc. | Anti-pd-1 antibodies for treatment of lung cancer |
| WO2018156740A1 (en) | 2017-02-24 | 2018-08-30 | Macrogenics, Inc. | Bispecific binding molecules that are capable of binding cd137 and tumor antigens, and uses thereof |
| CN110612447B (zh) | 2017-02-24 | 2024-02-06 | 德克萨斯州立大学董事会 | 用于检测早期胰腺癌的测定 |
| US11684672B2 (en) | 2017-02-24 | 2023-06-27 | Bayer Pharma Aktiengesellschaft | Combinations of copanlisib with anti-PD-1 antibody |
| WO2018154520A1 (en) | 2017-02-27 | 2018-08-30 | Glaxosmithkline Intellectual Property Development Limited | Heterocyclic amides as kinase inhibitors |
| EP3585486A1 (en) | 2017-02-27 | 2020-01-01 | Novartis AG | Dosing schedule for a combination of ceritinib and an anti-pd-1 antibody molecule |
| US20180271996A1 (en) | 2017-02-28 | 2018-09-27 | Mersana Therapeutics, Inc. | Combination therapies of her2-targeted antibody-drug conjugates |
| BR112019017743A2 (pt) | 2017-02-28 | 2020-04-07 | Sanofi Sa | rna terapêutico |
| EP3592868B1 (en) | 2017-03-06 | 2022-11-23 | Novartis AG | Methods of treatment of cancer with reduced ubb expression |
| US20200150125A1 (en) | 2017-03-12 | 2020-05-14 | Yeda Research And Development Co., Ltd. | Methods of diagnosing and prognosing cancer |
| WO2018167780A1 (en) | 2017-03-12 | 2018-09-20 | Yeda Research And Development Co. Ltd. | Methods of prognosing and treating cancer |
| WO2018170133A1 (en) | 2017-03-15 | 2018-09-20 | Amgen Inc. | Use of oncolytic viruses, alone or in combination with a checkpoint inhibitor, for the treatment of cancer |
| EP3600427A1 (en) | 2017-03-24 | 2020-02-05 | INSERM - Institut National de la Santé et de la Recherche Médicale | Methods and compositions for treating melanoma |
| EP3601338A4 (en) * | 2017-03-29 | 2020-12-16 | Celgene Corporation | FORMULATIONS INCLUDING PROTEINS BINDING PD-1 AND THEIR PREPARATION METHODS |
| JOP20190203A1 (ar) | 2017-03-30 | 2019-09-03 | Potenza Therapeutics Inc | بروتينات رابطة لمولد ضد مضادة لـ tigit وطرق استخدامها |
| WO2018183928A1 (en) | 2017-03-31 | 2018-10-04 | Bristol-Myers Squibb Company | Methods of treating tumor |
| US20200031944A1 (en) | 2017-03-31 | 2020-01-30 | Five Prime Therapeutics, Inc. | Combination therapy for cancer using anti-gitr antibodies |
| US20200115451A1 (en) * | 2017-03-31 | 2020-04-16 | Merck Sharp & Dohme Corp. | Compositions and methods for treating cancer with a combination of an antagonist of pd-1 and an anti-ctla4 antibody |
| AU2018241944A1 (en) | 2017-03-31 | 2019-08-15 | Boehringer Ingelheim International Gmbh | Anticancer combination therapy |
| WO2018185618A1 (en) | 2017-04-03 | 2018-10-11 | Novartis Ag | Anti-cdh6 antibody drug conjugates and anti-gitr antibody combinations and methods of treatment |
| CN110914300A (zh) | 2017-04-03 | 2020-03-24 | 安康乐济股份有限公司 | 使用ps靶向抗体与免疫肿瘤学药剂治疗癌症的方法 |
| EP3606946B1 (en) | 2017-04-03 | 2022-08-24 | F. Hoffmann-La Roche AG | Immunoconjugates of an anti-pd-1 antibody with a mutant il-2 or with il-15 |
| MA49042A (fr) | 2017-04-05 | 2020-02-12 | Symphogen As | Polythérapies ciblant pd-1, tim-3 et lag-3 |
| IL268527B2 (en) | 2017-04-05 | 2024-03-01 | Hoffmann La Roche | Bispecific antibodies specifically binding to pd1 and lag3 |
| EP3606556A1 (en) | 2017-04-05 | 2020-02-12 | Boehringer Ingelheim International GmbH | Anticancer combination therapy |
| US11603407B2 (en) | 2017-04-06 | 2023-03-14 | Regeneron Pharmaceuticals, Inc. | Stable antibody formulation |
| TWI788340B (zh) | 2017-04-07 | 2023-01-01 | 美商必治妥美雅史谷比公司 | 抗icos促效劑抗體及其用途 |
| KR20240017409A (ko) | 2017-04-13 | 2024-02-07 | 아게누스 인코포레이티드 | 항-cd137 항체 및 이의 사용 방법 |
| EP3612517B1 (en) | 2017-04-18 | 2022-03-02 | Tempest Therapeutics, Inc. | Bicyclic compounds and their use in the treatment of cancer |
| CN108728444A (zh) | 2017-04-18 | 2018-11-02 | 长春华普生物技术股份有限公司 | 免疫调节性多核苷酸及其应用 |
| US12460208B2 (en) | 2017-04-18 | 2025-11-04 | Parr Biotechnology Co., Ltd. | Immunomodulatory polynucleotides and uses thereof |
| US12134654B2 (en) | 2017-04-19 | 2024-11-05 | Marengo Therapeutics, Inc. | Multispecific molecules and uses thereof |
| CN106939049B (zh) | 2017-04-20 | 2019-10-01 | 苏州思坦维生物技术股份有限公司 | 拮抗抑制人pd-1抗原与其配体结合的单克隆抗体及其制备方法与应用 |
| EP4286009A3 (en) | 2017-04-21 | 2024-04-03 | Sillajen, Inc. | Oncolytic vaccinia virus and checkpoint inhibitor combination therapy |
| AR111419A1 (es) | 2017-04-27 | 2019-07-10 | Novartis Ag | Compuestos fusionados de indazol piridona como antivirales |
| CA3057157A1 (en) | 2017-04-28 | 2018-11-01 | Merck Sharp & Dohme Corp. | Biomarkers for cancer therapeutics |
| US20200179511A1 (en) | 2017-04-28 | 2020-06-11 | Novartis Ag | Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor |
| US20200055948A1 (en) | 2017-04-28 | 2020-02-20 | Novartis Ag | Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor |
| UY37695A (es) | 2017-04-28 | 2018-11-30 | Novartis Ag | Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo |
| EP4328241A3 (en) | 2017-04-28 | 2024-06-05 | Marengo Therapeutics, Inc. | Multispecific molecules comprising a non-immunoglobulin heterodimerization domain and uses thereof |
| AR111651A1 (es) | 2017-04-28 | 2019-08-07 | Novartis Ag | Conjugados de anticuerpos que comprenden agonistas del receptor de tipo toll y terapias de combinación |
| AU2018258661A1 (en) | 2017-04-28 | 2019-10-17 | Five Prime Therapeutics, Inc. | Methods of treatment with CD80 extracellular domain polypeptides |
| TWI805582B (zh) | 2017-05-01 | 2023-06-21 | 美商艾吉納斯公司 | 抗ｔｉｇｉｔ抗體類和使用彼等之方法 |
| JP7382232B2 (ja) | 2017-05-02 | 2023-11-16 | メルク・シャープ・アンド・ドーム・エルエルシー | 抗ｌａｇ３抗体の製剤および抗ｌａｇ３抗体と抗ｐｄ－１抗体との共製剤 |
| JOP20190260A1 (ar) | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها |
| UY37718A (es) | 2017-05-05 | 2018-11-30 | Novartis Ag | 2-quinolinonas triciclicas como agentes antibacteriales |
| CA3063201A1 (en) | 2017-05-09 | 2018-11-15 | Tesaro, Inc. | Combination therapies for treating cancer |
| IL300964A (en) | 2017-05-12 | 2023-04-01 | Harpoon Therapeutics Inc | mesothelin binding proteins |
| WO2018208667A1 (en) | 2017-05-12 | 2018-11-15 | Merck Sharp & Dohme Corp. | Cyclic di-nucleotide compounds as sting agonists |
| JOP20190256A1 (ar) | 2017-05-12 | 2019-10-28 | Icahn School Med Mount Sinai | فيروسات داء نيوكاسل واستخداماتها |
| JP7274426B2 (ja) | 2017-05-16 | 2023-05-16 | ブリストル－マイヤーズ スクイブ カンパニー | 抗ｇｉｔｒアゴニスト抗体での癌の処置 |
| CA3063893A1 (en) * | 2017-05-16 | 2018-11-22 | Immunogen, Inc. | Anti-folr1 immunoconjugates and anti-pd-1 antibody combinations |
| CA3062656A1 (en) | 2017-05-17 | 2018-11-22 | Boston Biomedical, Inc. | Methods for treating cancer |
| US11421011B2 (en) | 2017-05-18 | 2022-08-23 | Modernatx, Inc. | Polynucleotides encoding tethered interleukin-12 (IL12) polypeptides and uses thereof |
| EP3624850A1 (en) | 2017-05-18 | 2020-03-25 | Tesaro, Inc. | Combination therapies for treating cancer |
| AR111760A1 (es) | 2017-05-19 | 2019-08-14 | Novartis Ag | Compuestos y composiciones para el tratamiento de tumores sólidos mediante administración intratumoral |
| PE20200303A1 (es) | 2017-05-24 | 2020-02-06 | Novartis Ag | Proteinas de anticuerpo injertadas con citocina y metodos de uso en el tratamiento del cancer |
| WO2018215937A1 (en) | 2017-05-24 | 2018-11-29 | Novartis Ag | Interleukin-7 antibody cytokine engrafted proteins and methods of use in the treatment of cancer |
| CN111107868A (zh) | 2017-05-24 | 2020-05-05 | 诺华股份有限公司 | 抗体细胞因子移植蛋白及使用方法 |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| CN111108123A (zh) | 2017-05-29 | 2020-05-05 | 加马玛布斯制药公司 | 癌症相关的免疫抑制抑制剂 |
| PT3631454T (pt) | 2017-05-30 | 2023-11-23 | Bristol Myers Squibb Co | Tratamento de tumores positivos para lag-3 |
| AU2018277559A1 (en) | 2017-05-30 | 2019-10-17 | Bristol-Myers Squibb Company | Compositions comprising a combination of an anti-LAG-3 antibody, a PD-1 pathway inhibitor, and an immunotherapeutic agent |
| EP3630179A2 (en) | 2017-05-30 | 2020-04-08 | Bristol-Myers Squibb Company | Compositions comprising an anti-lag-3 antibody or an anti-lag-3 antibody and an anti-pd-1 or anti-pd-l1 antibody |
| AU2018277545B2 (en) | 2017-05-31 | 2025-05-15 | Stcube & Co., Inc. | Methods of treating cancer using antibodies and molecules that immunospecifically bind to BTN1A1 |
| WO2018222901A1 (en) | 2017-05-31 | 2018-12-06 | Elstar Therapeutics, Inc. | Multispecific molecules that bind to myeloproliferative leukemia (mpl) protein and uses thereof |
| JOP20190279A1 (ar) | 2017-05-31 | 2019-11-28 | Novartis Ag | الصور البلورية من 5-برومو -2، 6-داي (1h-بيرازول -1-يل) بيريميدين -4- أمين وأملاح جديدة |
| US20200181274A1 (en) | 2017-06-01 | 2020-06-11 | Novartis Ag | Bispecific antibodies that bind cd 123 cd3 |
| WO2018223004A1 (en) | 2017-06-01 | 2018-12-06 | Xencor, Inc. | Bispecific antibodies that bind cd20 and cd3 |
| EP3630838A1 (en) | 2017-06-01 | 2020-04-08 | CytomX Therapeutics, Inc. | Activatable anti-pdl1 antibodies, and methods of use thereof |
| CN110678483B (zh) | 2017-06-01 | 2023-09-22 | 百时美施贵宝公司 | 用抗pd-1抗体治疗肿瘤的方法 |
| EP3630822A1 (en) | 2017-06-02 | 2020-04-08 | Boehringer Ingelheim International GmbH | Anti-cancer combination therapy |
| WO2018222989A1 (en) | 2017-06-02 | 2018-12-06 | The Penn State Research Foundation | Ceramide nanoliposomes, compositions and methods of using for immunotherapy |
| CA3065120A1 (en) | 2017-06-02 | 2018-12-06 | Juno Therapeutics, Inc. | Articles of manufacture and methods for treatment using adoptive cell therapy |
| WO2018226671A1 (en) | 2017-06-06 | 2018-12-13 | Stcube & Co., Inc. | Methods of treating cancer using antibodies and molecules that bind to btn1a1 or btn1a1-ligands |
| WO2018225093A1 (en) | 2017-06-07 | 2018-12-13 | Glaxosmithkline Intellectual Property Development Limited | Chemical compounds as atf4 pathway inhibitors |
| CA3066048A1 (en) | 2017-06-09 | 2018-12-13 | Glaxosmithkline Intellectual Property Development Limited | Combination therapy |
| WO2018224166A1 (en) | 2017-06-09 | 2018-12-13 | Biontech Rna Pharmaceuticals Gmbh | Methods for predicting the usefulness of disease specific amino acid modifications for immunotherapy |
| ES3000510T3 (en) | 2017-06-09 | 2025-02-28 | Providence Health & Services Oregon | Tumor-infiltrating t-cells for use in the treatment of cancer |
| WO2018229715A1 (en) | 2017-06-16 | 2018-12-20 | Novartis Ag | Compositions comprising anti-cd32b antibodies and methods of use thereof |
| CN107083398A (zh) * | 2017-06-16 | 2017-08-22 | 深圳惠升生物科技有限公司 | 植物作为宿主在表达pd‑1抗体和/或pd‑l1抗体中的应用 |
| WO2018234367A1 (en) | 2017-06-20 | 2018-12-27 | Institut Curie | SUV39H1 HISTONE METHYLTRANSFERASE INHIBITOR FOR USE IN ANTICANCER POLYTHERAPY |
| US20200172628A1 (en) | 2017-06-22 | 2020-06-04 | Novartis Ag | Antibody molecules to cd73 and uses thereof |
| AU2018289539B2 (en) | 2017-06-22 | 2024-07-04 | Celgene Corporation | Treatment of hepatocellular carcinoma characterized by hepatitis B virus infection |
| WO2018237157A1 (en) | 2017-06-22 | 2018-12-27 | Novartis Ag | CD73 BINDING ANTIBODY MOLECULES AND USES THEREOF |
| CN110799537B (zh) * | 2017-06-25 | 2023-07-28 | 西雅图免疫公司 | 抗pd-1抗体及其制备和使用方法 |
| KR102757960B1 (ko) | 2017-06-26 | 2025-01-22 | 베이진 엘티디 | 간세포암(hepatocellular carcinoma: HCC)에 대한 면역 치료 |
| JP2020525483A (ja) | 2017-06-27 | 2020-08-27 | ノバルティス アーゲー | 抗ｔｉｍ−３抗体のための投与レジメンおよびその使用 |
| MX2019015155A (es) | 2017-06-29 | 2020-08-03 | Juno Therapeutics Inc | Modelo de raton para valorar toxicidades asociadas con inmunoterapias. |
| SMT202300068T1 (it) | 2017-06-30 | 2023-03-17 | Celgene Corp | Composizioni e metodi d'uso di 2-(4-clorofenil)-n-((2-(2,6-diossopiperidin-3-il)-1-ossoisoindolin-5-il)metil)-2,2-difluoroacetammide |
| CN111164069A (zh) | 2017-07-03 | 2020-05-15 | 葛兰素史密斯克莱知识产权发展有限公司 | 作为atf4抑制剂用于治疗癌症和其它疾病的n-(3-(2-(4-氯苯氧基)乙酰胺基)双环[1.1.1]戊-1-基)-2-环丁烷-1-甲酰胺衍生物以及相关化合物 |
| EP3649108A1 (en) | 2017-07-03 | 2020-05-13 | GlaxoSmithKline Intellectual Property Development Limited | 2-(4-chlorophenoxy)-n-((1 -(2-(4-chlorophenoxy)ethynazetidin-3-yl)methyl)acetamide derivatives and related compounds as atf4 inhibitors for treating cancer and other diseases |
| WO2019011855A1 (en) | 2017-07-10 | 2019-01-17 | Innate Pharma | ANTIBODIES NEUTRALIZING SIGLEC-9 |
| EP3651766B1 (en) | 2017-07-10 | 2024-09-11 | Celgene Corporation | 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-l-yl)-3-fluorobenzonitrile as antiproliferative compound |
| CN111793060B (zh) | 2017-07-14 | 2023-06-06 | 先天肿瘤免疫公司 | Nlrp3调节剂 |
| EP3655542A1 (en) | 2017-07-18 | 2020-05-27 | Institut Gustave Roussy | Method for assessing the response to pd-1/pdl-1 targeting drugs |
| IL319798A (en) | 2017-07-20 | 2025-05-01 | Novartis Ag | ANTI-LAG-3 Antibody Dosage Regimens and Their Uses |
| MX2020000604A (es) | 2017-07-21 | 2020-09-10 | Genentech Inc | Métodos terapéuticos y de diagnóstico para el cáncer. |
| US11926664B2 (en) | 2017-07-25 | 2024-03-12 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for modulating monocytopoiesis |
| WO2019021208A1 (en) | 2017-07-27 | 2019-01-31 | Glaxosmithkline Intellectual Property Development Limited | USEFUL INDAZOLE DERIVATIVES AS PERK INHIBITORS |
| US11899017B2 (en) | 2017-07-28 | 2024-02-13 | Bristol-Myers Squibb Company | Predictive peripheral blood biomarker for checkpoint inhibitors |
| AU2018311965A1 (en) | 2017-08-04 | 2020-02-13 | Merck Sharp & Dohme Llc | Combinations of PD-1 antagonists and benzo[b]thiophene sting antagonists for cancer treatment |
| JP2020530838A (ja) | 2017-08-04 | 2020-10-29 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | がん治療のためのベンゾ［ｂ］チオフェンＳＴＩＮＧアゴニスト |
| US10544162B2 (en) | 2017-08-18 | 2020-01-28 | Adastra Pharmaceuticals, Inc. | Polymorphic form of TG02 |
| CA3078605A1 (en) | 2017-08-28 | 2019-03-07 | Bristol-Myers Squibb Company | Tim-3 antagonists for the treatment and diagnosis of cancers |
| KR20200052327A (ko) * | 2017-09-04 | 2020-05-14 | 아게누스 인코포레이티드 | 혼합 계통 백혈병 (mll)-특이적 포스포펩타이드에 결합하는 t 세포 수용체 및 그것의 사용 방법 |
| TW201922721A (zh) | 2017-09-07 | 2019-06-16 | 英商葛蘭素史克智慧財產發展有限公司 | 化學化合物 |
| WO2019053617A1 (en) | 2017-09-12 | 2019-03-21 | Glaxosmithkline Intellectual Property Development Limited | CHEMICAL COMPOUNDS |
| JP7196160B2 (ja) | 2017-09-12 | 2022-12-26 | スミトモ ファーマ オンコロジー， インコーポレイテッド | Ｍｃｌ－１阻害剤アルボシジブを用いた、ｂｃｌ－２阻害剤に対して非感受性である癌の治療レジメン |
| EP3684410A1 (en) | 2017-09-19 | 2020-07-29 | Institut Curie | Agonist of aryl hydrocarbon receptor for use in cancer combination therapy |
| KR102677442B1 (ko) | 2017-09-25 | 2024-06-20 | 케모센트릭스, 인크. | 케모카인 수용체 2(ccr2) 길항제 및 pd-1/pd-l1 억제제를 사용하는 병용 요법 |
| JP2020535180A (ja) | 2017-09-29 | 2020-12-03 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 抗ｉｇｆ、抗ｐｆ−１の抗がん組み合わせ治療 |
| US11351163B2 (en) | 2017-09-29 | 2022-06-07 | Bristol-Myers Squibb Company | Compositions and methods of treating cancer |
| WO2019061324A1 (en) | 2017-09-29 | 2019-04-04 | Curis Inc. | CRYSTALLINE FORMS OF IMMUNOMODULATORS |
| MX2020003770A (es) | 2017-09-30 | 2020-07-29 | Tesaro Inc | Terapias de combinacion para tratar cancer. |
| WO2019070497A1 (en) | 2017-10-04 | 2019-04-11 | Imclone Llc | POLY THERAPY AGAINST CANCER |
| EP3692034A1 (en) | 2017-10-05 | 2020-08-12 | GlaxoSmithKline Intellectual Property Development Limited | Modulators of stimulator of interferon genes (sting) |
| US20210238172A1 (en) | 2017-10-05 | 2021-08-05 | Glaxosmithkline Intellectual Property Development Limited | Heterocyclic amides useful as protein modulators and methods of using the same |
| BR112020006879A2 (pt) * | 2017-10-06 | 2020-10-06 | The Wistar Institute Of Anatomy And Biology | composição para gerar um ou mais anticorpos anti-ctla-4 ou fragmentos dos mesmos em um sujeito, e, métodos para tratar uma doença em um sujeito e para aumentar uma resposta imune em um sujeito em necessidade do mesmo |
| KR20200067164A (ko) | 2017-10-06 | 2020-06-11 | 테사로, 인코포레이티드 | 조합 요법 및 그의 용도 |
| US20200256877A1 (en) | 2017-10-09 | 2020-08-13 | Enterome S.A. | Microbiota Sequence Variants Of Tumor-Related Antigenic Epitopes |
| SG11202003081WA (en) | 2017-10-11 | 2020-05-28 | Aurigene Discovery Tech Ltd | Crystalline forms of 3-substituted 1,2,4-oxadiazole |
| AU2018346957B2 (en) | 2017-10-12 | 2024-08-01 | Board Of Regents, The University Of Texas System | T cell receptors for immunotherapy |
| CA3075291A1 (en) | 2017-10-13 | 2019-04-18 | Merck Sharp & Dohme Corp. | Compositions and methods for treating diffuse large b cell lymphoma |
| FI3694529T3 (fi) | 2017-10-13 | 2024-09-17 | Harpoon Therapeutics Inc | Trispesifiset proteiinit ja niiden käyttömenetelmät |
| IL315737A (en) | 2017-10-13 | 2024-11-01 | Harpoon Therapeutics Inc | B-cell maturation antigen-binding proteins |
| KR20200064132A (ko) | 2017-10-15 | 2020-06-05 | 브리스톨-마이어스 스큅 컴퍼니 | 종양을 치료하는 방법 |
| CA3079310A1 (en) | 2017-10-18 | 2019-04-25 | Vivia Biotech, S.L. | Bite-activated car-t cells |
| EP3700933A1 (en) | 2017-10-25 | 2020-09-02 | Novartis AG | Antibodies targeting cd32b and methods of use thereof |
| JP2021501150A (ja) | 2017-10-27 | 2021-01-14 | メルク・シャープ・エンド・ドーム・コーポレイション | 肝臓がんを治療するための組成物及び方法 |
| WO2019089753A2 (en) | 2017-10-31 | 2019-05-09 | Compass Therapeutics Llc | Cd137 antibodies and pd-1 antagonists and uses thereof |
| EP3703749A1 (en) | 2017-10-31 | 2020-09-09 | Janssen Biotech, Inc. | Methods of treating high risk multiple myeloma |
| PE20200850A1 (es) | 2017-11-01 | 2020-08-20 | Juno Therapeutics Inc | Receptores de antigenos quimericos especificos para el antigeno de maduracion de celulas b y polinucleotidos que codifican los mismos |
| US12031975B2 (en) | 2017-11-01 | 2024-07-09 | Juno Therapeutics, Inc. | Methods of assessing or monitoring a response to a cell therapy |
| MX2020004243A (es) | 2017-11-01 | 2020-09-25 | Juno Therapeutics Inc | Receptores de anticuerpos y de antigenos quimericos especificos para el antigeno de maduracion de celulas b. |
| WO2019089412A1 (en) | 2017-11-01 | 2019-05-09 | Merck Sharp & Dohme Corp. | Novel substituted tetrahydroquinolin compounds as indoleamine 2,3-dioxygenase (ido) inhibitors |
| EA202090746A1 (ru) | 2017-11-03 | 2020-08-17 | Ориджен Дискавери Текнолоджис Лимитед | Двойные ингибиторы путей tim-3 и pd-1 |
| EP3706798A1 (en) | 2017-11-06 | 2020-09-16 | Aurigene Discovery Technologies Limited | Conjoint therapies for immunomodulation |
| WO2019090330A1 (en) | 2017-11-06 | 2019-05-09 | Bristol-Myers Squibb Company | Methods of treating a tumor |
| JP7339944B2 (ja) | 2017-11-07 | 2023-09-06 | ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム | がんの処置におけるｃａｒ－ｔ細胞またはｃａｒ－ｎｋ細胞を用いるｌｉｌｒｂ４のターゲティング法 |
| WO2019094637A1 (en) | 2017-11-08 | 2019-05-16 | Xencor, Inc. | Bispecific and monospecific antibodies using novel anti-pd-1 sequences |
| JP7269928B2 (ja) | 2017-11-14 | 2023-05-09 | メルク・シャープ・アンド・ドーム・エルエルシー | インドールアミン ２，３－ジオキシゲナーゼ（ｉｄｏ）阻害剤としての新規の置換ビアリール化合物 |
| EP3709986B1 (en) | 2017-11-14 | 2023-11-01 | Merck Sharp & Dohme LLC | Novel substituted biaryl compounds as indoleamine 2,3-dioxygenase (ido) inhibitors |
| WO2019099838A1 (en) | 2017-11-16 | 2019-05-23 | Novartis Ag | Combination therapies |
| CN111315749A (zh) | 2017-11-17 | 2020-06-19 | 诺华股份有限公司 | 新颖的二氢异噁唑化合物及其在治疗乙型肝炎中的用途 |
| WO2019099597A2 (en) | 2017-11-17 | 2019-05-23 | Merck Sharp & Dohme Corp. | Antibodies specific for immunoglobulin-like transcript 3 (ilt3) and uses thereof |
| CA3083158A1 (en) | 2017-11-24 | 2019-05-31 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Methods and compositions for treating cancers |
| WO2019104289A1 (en) | 2017-11-27 | 2019-05-31 | Mersana Therapeutics, Inc. | Pyrrolobenzodiazepine antibody conjugates |
| WO2019108795A1 (en) | 2017-11-29 | 2019-06-06 | Beigene Switzerland Gmbh | Treatment of indolent or aggressive b-cell lymphomas using a combination comprising btk inhibitors |
| RU2020121458A (ru) | 2017-11-30 | 2021-12-30 | Новартис Аг | Химерный антигенный рецептор, нацеливающийся на bcma, и его пути применения |
| EP3720881A1 (en) | 2017-12-08 | 2020-10-14 | Elstar Therapeutics, Inc. | Multispecific molecules and uses thereof |
| EP3724225A1 (en) | 2017-12-15 | 2020-10-21 | Juno Therapeutics, Inc. | Anti-cct5 binding molecules and methods of use thereof |
| WO2019123285A1 (en) | 2017-12-20 | 2019-06-27 | Novartis Ag | Fused tricyclic pyrazolo-dihydropyrazinyl-pyridone compounds as antivirals |
| EP3727401A4 (en) | 2017-12-20 | 2022-04-06 | Merck Sharp & Dohme Corp. | CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS |
| CN111757757A (zh) | 2017-12-21 | 2020-10-09 | 梅尔莎纳医疗公司 | 吡咯并苯并二氮呯抗体共轭物 |
| JP7369127B2 (ja) | 2017-12-28 | 2023-10-25 | ナンジン レジェンド バイオテック カンパニー，リミテッド | Ｔｉｇｉｔに対する単一ドメイン抗体及びその変異体 |
| CA3087230A1 (en) | 2017-12-28 | 2019-07-04 | The General Hospital Corporation | Targeting the cbm signalosome complex induces regulatory t cells to inflame the tumor microenvironment |
| US20210072244A1 (en) | 2018-01-04 | 2021-03-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treating melanoma resistant |
| US20190269664A1 (en) | 2018-01-08 | 2019-09-05 | Chemocentryx, Inc. | Methods of treating solid tumors with ccr2 antagonists |
| CN112218651A (zh) | 2018-01-08 | 2021-01-12 | 诺华公司 | 用于与嵌合抗原受体疗法组合的免疫增强rna |
| JP7442141B2 (ja) | 2018-01-08 | 2024-03-04 | ケモセントリックス，インコーポレイティド | Ｃｃｒ２アンタゴニストによる固形腫瘍の治療方法 |
| WO2019139921A1 (en) | 2018-01-09 | 2019-07-18 | Shuttle Pharmaceuticals, Inc. | Selective histone deacetylase inhibitors for the treatment of human disease |
| US12247060B2 (en) | 2018-01-09 | 2025-03-11 | Marengo Therapeutics, Inc. | Calreticulin binding constructs and engineered T cells for the treatment of diseases |
| JP2021510697A (ja) | 2018-01-12 | 2021-04-30 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | がん処置のための坑ｉｌ−８抗体及び坑ｐｄ−１抗体を用いる組合せ治療 |
| CA3125731A1 (en) | 2018-01-12 | 2019-07-18 | KDAc Therapeutics, Inc. | Combination of a selective histone deacetylase 3 (hdac3) inhibitor and an immunotherapy agent for the treatment of cancer |
| TWI802633B (zh) | 2018-01-15 | 2023-05-21 | 大陸商南京傳奇生物科技有限公司 | 針對pd-1之單域抗體及其變異體 |
| CN111868091A (zh) | 2018-01-16 | 2020-10-30 | 百时美施贵宝公司 | 用抗tim3抗体治疗癌症的方法 |
| US12398209B2 (en) | 2018-01-22 | 2025-08-26 | Janssen Biotech, Inc. | Methods of treating cancers with antagonistic anti-PD-1 antibodies |
| MX2020007526A (es) | 2018-01-22 | 2020-09-09 | Bristol Myers Squibb Co | Composiciones y metodos para tratar el cancer. |
| CA3096287A1 (en) | 2018-01-22 | 2019-07-25 | Pascal Biosciences Inc. | Cannabinoids and derivatives for promoting immunogenicity of tumor and infected cells |
| US20200354424A1 (en) | 2018-01-26 | 2020-11-12 | Orionis Biosciences, Inc. | Xcr1 binding agents and uses thereof |
| US20200354457A1 (en) | 2018-01-31 | 2020-11-12 | Hoffmann-La Roche Inc. | Bispecific antibodies comprising an antigen-binding site binding to lag3 |
| US20210038659A1 (en) | 2018-01-31 | 2021-02-11 | Novartis Ag | Combination therapy using a chimeric antigen receptor |
| US20210069246A1 (en) | 2018-01-31 | 2021-03-11 | Celgene Corporation | Combination therapy using adoptive cell therapy and checkpoint inhibitor |
| WO2019148410A1 (en) * | 2018-02-01 | 2019-08-08 | Merck Sharp & Dohme Corp. | Anti-pd-1 antibodies |
| WO2019148412A1 (en) * | 2018-02-01 | 2019-08-08 | Merck Sharp & Dohme Corp. | Anti-pd-1/lag3 bispecific antibodies |
| KR102877915B1 (ko) | 2018-02-05 | 2025-10-29 | 오리오니스 바이오사이언시즈 인코포레이티드 | 섬유아세포 결합제 및 이의 용도 |
| CN117643587A (zh) | 2018-02-05 | 2024-03-05 | 深圳市原力生命科学有限公司 | 用于治疗癌症的杂二环羧酸 |
| WO2019157124A1 (en) | 2018-02-08 | 2019-08-15 | Bristol-Myers Squibb Company | Combination of a tetanus toxoid, anti-ox40 antibody and/or anti-pd-1 antibody to treat tumors |
| WO2019153200A1 (zh) | 2018-02-08 | 2019-08-15 | 北京韩美药品有限公司 | 抗pd-1/抗her2天然抗体结构样异源二聚体形式双特异抗体及其制备 |
| NL2020422B1 (en) | 2018-02-12 | 2019-08-19 | Stichting Het Nederlands Kanker Inst Antoni Van Leeuwenhoek Ziekenhuis | Methods for Predicting Treatment Outcome and/or for Selecting a Subject Suitable for Immune Checkpoint Therapy. |
| KR20200119845A (ko) * | 2018-02-13 | 2020-10-20 | 머크 샤프 앤드 돔 코포레이션 | 항 pd-1 항체 및 항 ctla4 항체를 사용한 암의 치료 방법 |
| WO2019160956A1 (en) | 2018-02-13 | 2019-08-22 | Novartis Ag | Chimeric antigen receptor therapy in combination with il-15r and il15 |
| WO2019160751A2 (en) | 2018-02-13 | 2019-08-22 | Merck Sharp & Dohme Corp. | Methods for treating cancer with anti-pd-1 antibodies |
| AU2019226011B2 (en) | 2018-02-21 | 2025-11-27 | Five Prime Therapeutics, Inc. | B7-H4 antibody formulations |
| WO2019162325A1 (en) | 2018-02-21 | 2019-08-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of sk1 as biomarker for predicting response to immunecheckpoint inhibitors |
| WO2019165195A1 (en) | 2018-02-22 | 2019-08-29 | Srivastava Satish | Combination therapy for the treatment of cancer |
| CA3091502A1 (en) | 2018-02-23 | 2019-08-29 | Eucure (Beijing) Biopharma Co., Ltd | Anti-pd-1 antibodies and uses thereof |
| MX2020008949A (es) | 2018-02-27 | 2021-01-08 | Incyte Corp | Imidazopirimidinas y triazolopirimidinas como inhibidores de a2a / a2b. |
| JP2021514982A (ja) | 2018-02-28 | 2021-06-17 | ノバルティス アーゲー | インドール−２−カルボニル化合物及びｂ型肝炎治療のためのそれらの使用 |
| JP2021517127A (ja) | 2018-03-06 | 2021-07-15 | アンスティテュ キュリィ | 癌併用療法における使用のためのｓｅｔｄｂ１ヒストンメチルトランスフェラーゼの阻害剤 |
| IL277095B2 (en) | 2018-03-07 | 2025-10-01 | Pfizer | Preparations containing anti-PD-1 antibody |
| GB201803745D0 (en) * | 2018-03-08 | 2018-04-25 | Ultrahuman Eight Ltd | PD1 binding agents |
| WO2019177873A1 (en) | 2018-03-13 | 2019-09-19 | Merck Sharp & Dohme Corp. | Arginase inhibitors and methods of use |
| BR122022000386B1 (pt) | 2018-03-14 | 2022-09-27 | Surface Oncology, Inc | Anticorpos que se ligam a cd39, composição farmacêutica e kit dos mesmos |
| US20210009711A1 (en) | 2018-03-14 | 2021-01-14 | Elstar Therapeutics, Inc. | Multifunctional molecules and uses thereof |
| WO2019178362A1 (en) | 2018-03-14 | 2019-09-19 | Elstar Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| AU2019322487B2 (en) | 2018-03-19 | 2024-04-18 | Multivir Inc. | Methods and compositions comprising tumor suppressor gene therapy and CD122/CD132 agonists for the treatment of cancer |
| TWI841554B (zh) | 2018-03-21 | 2024-05-11 | 丹麥商珍美寶股份有限公司 | 以鉑為主之劑與抗組織因子抗體－藥物共軛物的組合治療癌症之方法 |
| JP7328983B2 (ja) | 2018-03-22 | 2023-08-17 | サーフィス オンコロジー インコーポレイテッド | 抗ｉｌ－２７抗体及びその使用 |
| AU2019236865A1 (en) | 2018-03-23 | 2020-10-01 | Bristol-Myers Squibb Company | Antibodies against MICA and/or MICB and uses thereof |
| US10760075B2 (en) | 2018-04-30 | 2020-09-01 | Snipr Biome Aps | Treating and preventing microbial infections |
| KR20210006344A (ko) | 2018-03-25 | 2021-01-18 | 에스엔아이피알 바이옴 에이피에스. | 미생물 감염의 치료 및 예방 |
| CA3094108A1 (en) | 2018-03-27 | 2019-10-03 | Board Of Regents, The University Of Texas Systems | Compounds with anti-tumor activity against cancer cells bearing her2 exon 19 mutations |
| WO2019185792A1 (en) | 2018-03-29 | 2019-10-03 | Philogen S.P.A | Cancer treatment using immunoconjugates and immune check-point inhibitors |
| CN108530537B (zh) * | 2018-03-29 | 2019-07-02 | 中国人民解放军军事科学院军事医学研究院 | Pd-1/pd-l1信号通路抑制剂 |
| HRP20230090T1 (hr) | 2018-03-30 | 2023-03-17 | Incyte Corporation | Heterociklički spojevi kao imunomodulatori |
| KR20200139724A (ko) | 2018-03-30 | 2020-12-14 | 브리스톨-마이어스 스큅 컴퍼니 | 종양을 치료하는 방법 |
| EP3774765A4 (en) | 2018-04-03 | 2021-12-29 | Merck Sharp & Dohme Corp. | Aza-benzothiophene compounds as sting agonists |
| TWI793294B (zh) | 2018-04-03 | 2023-02-21 | 美商默沙東有限責任公司 | Sting促效劑化合物 |
| EP3774903A1 (en) | 2018-04-04 | 2021-02-17 | Bristol-Myers Squibb Company | Anti-cd27 antibodies and uses thereof |
| WO2019195658A1 (en) | 2018-04-05 | 2019-10-10 | Dana-Farber Cancer Institute, Inc. | Sting levels as a biomarker for cancer immunotherapy |
| WO2019193540A1 (en) | 2018-04-06 | 2019-10-10 | Glaxosmithkline Intellectual Property Development Limited | Heteroaryl derivatives of formula (i) as atf4 inhibitors |
| WO2019193541A1 (en) | 2018-04-06 | 2019-10-10 | Glaxosmithkline Intellectual Property Development Limited | Bicyclic aromatic ring derivatives of formula (i) as atf4 inhibitors |
| SG11202009839PA (en) | 2018-04-12 | 2020-11-27 | Bristol Myers Squibb Co | Anticancer combination therapy with cd73 antagonist antibody and pd-1/pd-l1 axis antagonist antibody |
| US20210147547A1 (en) | 2018-04-13 | 2021-05-20 | Novartis Ag | Dosage Regimens For Anti-Pd-L1 Antibodies And Uses Thereof |
| WO2019200214A1 (en) | 2018-04-13 | 2019-10-17 | The Regents Of The University Of Michigan | Compositions and methods for treating cancer |
| BR112020021042A2 (pt) | 2018-04-17 | 2021-01-19 | Tempest Therapeutics, Inc. | Carboxamidas bicíclicas e métodos de uso das mesmas |
| CN112105645A (zh) | 2018-04-18 | 2020-12-18 | Xencor股份有限公司 | Il-15/il-15ra异二聚体fc融合蛋白及其用途 |
| WO2019204665A1 (en) | 2018-04-18 | 2019-10-24 | Xencor, Inc. | Pd-1 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and pd-1 antigen binding domains and uses thereof |
| JP7366057B2 (ja) | 2018-04-19 | 2023-10-20 | チェックメイト ファーマシューティカルズ， インコーポレイテッド | 合成ｒｉｇ－ｉ様受容体アゴニスト |
| US11542505B1 (en) | 2018-04-20 | 2023-01-03 | Merck Sharp & Dohme Llc | Substituted RIG-I agonists: compositions and methods thereof |
| AU2019261582A1 (en) | 2018-04-25 | 2020-11-12 | Innate Tumor Immunity, Inc. | NLRP3 modulators |
| WO2019207030A1 (en) | 2018-04-26 | 2019-10-31 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting a response with an immune checkpoint inhibitor in a patient suffering from a lung cancer |
| CN112218883A (zh) | 2018-04-26 | 2021-01-12 | 艾吉纳斯公司 | 热休克蛋白结合肽组合物及其使用方法 |
| JP6630026B1 (ja) * | 2018-04-27 | 2020-01-15 | 隆代 大田 | 免疫チェックポイント阻害剤によるがん治療の効果を評価するためのバイオマーカー |
| EP3784351A1 (en) | 2018-04-27 | 2021-03-03 | Novartis AG | Car t cell therapies with enhanced efficacy |
| CN108840932B (zh) * | 2018-04-28 | 2022-03-29 | 中国科学院微生物研究所 | 一种pd-1特异性抗体及其抗肿瘤应用 |
| EP3788369A1 (en) | 2018-05-01 | 2021-03-10 | Novartis Ag | Biomarkers for evaluating car-t cells to predict clinical outcome |
| CR20240498A (es) | 2018-05-04 | 2025-01-08 | Incyte Corp | FORMAS SÓLIDAS DE UN INHIBIDOR DE FGFR Y PROCESOS PARA PREPARARLAS (Divisional EXP. 2020-0590) |
| BR112020022373A2 (pt) | 2018-05-04 | 2021-02-02 | Incyte Corporation | sais de um inibidor de fgfr |
| CA3099079A1 (en) | 2018-05-04 | 2019-11-07 | Merck Patent Gmbh | Combined inhibition of pd-1/pd-l1, tgf.beta. and dna-pk for the treatment of cancer |
| UA130009C2 (uk) | 2018-05-07 | 2025-10-15 | Генмаб А/С | Спосіб лікування раку за допомогою комбінації антитіла до pd-1 і кон'югата антитіла до тканинного фактора і лікарського засобу |
| PT3790877T (pt) | 2018-05-11 | 2023-05-10 | Incyte Corp | Derivados de tetrahidro-imidazo[4,5-c]piridina como imunomoduladores pd-l1 |
| JP7531404B2 (ja) | 2018-05-15 | 2024-08-09 | メディミューン リミテッド | 癌の処置 |
| CN112384624A (zh) | 2018-05-15 | 2021-02-19 | 杜克大学 | 用于对阿克曼菌进行基因操纵的系统和方法 |
| GB201807924D0 (en) | 2018-05-16 | 2018-06-27 | Ctxt Pty Ltd | Compounds |
| CA3100731A1 (en) | 2018-05-18 | 2019-11-21 | Incyte Corporation | Fused pyrimidine derivatives as a2a / a2b inhibitors |
| EP3569618A1 (en) | 2018-05-19 | 2019-11-20 | Boehringer Ingelheim International GmbH | Antagonizing cd73 antibody |
| CN112399848B (zh) | 2018-05-23 | 2024-09-06 | 细胞基因公司 | 用于组合使用的抗增殖化合物和针对bcma和cd3的双特异性抗体 |
| SG11202011568XA (en) | 2018-05-23 | 2020-12-30 | Celgene Corp | Treating multiple myeloma and the use of biomarkers for 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1- oxoisoindolin-4-yl)oxy)methyl)benzyl) piperazin-1-yl)-3-fluorobenzonitrile |
| TWI806870B (zh) * | 2018-05-23 | 2023-07-01 | 中國大陸商大有華夏生物醫藥集團有限公司 | 抗pd-1抗體及其用途 |
| WO2019225787A1 (ko) | 2018-05-24 | 2019-11-28 | 에이비엘바이오 주식회사 | 항-b7-h3 항체 및 그 용도 |
| WO2019224385A2 (en) * | 2018-05-24 | 2019-11-28 | Glenmark Pharmaceuticals S.A. | Combined bispecific antibody and immuno-oncology therapies |
| AR126019A1 (es) | 2018-05-30 | 2023-09-06 | Novartis Ag | Anticuerpos frente a entpd2, terapias de combinación y métodos de uso de los anticuerpos y las terapias de combinación |
| WO2019232319A1 (en) | 2018-05-31 | 2019-12-05 | Peloton Therapeutics, Inc. | Compositions and methods for inhibiting cd73 |
| CN112165974B (zh) | 2018-05-31 | 2024-11-08 | 诺华股份有限公司 | 乙型肝炎抗体 |
| US11352320B2 (en) | 2018-05-31 | 2022-06-07 | Merck Sharp & Dohme Corp. | Substituted [1.1.1] bicyclo compounds as indoleamine 2,3-dioxygenase inhibitors |
| CN118130807A (zh) | 2018-05-31 | 2024-06-04 | 小野药品工业株式会社 | 用于确定免疫检查点抑制剂的有效性的生物标志物 |
| WO2019232244A2 (en) | 2018-05-31 | 2019-12-05 | Novartis Ag | Antibody molecules to cd73 and uses thereof |
| AU2019276656A1 (en) | 2018-06-01 | 2021-01-07 | Novartis Ag | Dosing of a bispecific antibody that bind CD123 and CD3 |
| PE20210320A1 (es) | 2018-06-01 | 2021-02-16 | Novartis Ag | Moleculas de union contra bcma y usos de las mismas |
| CA3102398A1 (en) | 2018-06-03 | 2019-12-12 | Lamkap Bio Beta Ltd. | Bispecific antibodies against ceacam5 and cd47 |
| CN112566643A (zh) | 2018-06-12 | 2021-03-26 | 加利福尼亚大学董事会 | 用于治疗癌症的单链双特异性嵌合抗原受体 |
| JP7438988B2 (ja) | 2018-06-13 | 2024-02-27 | ノバルティス アーゲー | Ｂｃｍａキメラ抗原受容体及びその使用 |
| KR20210035805A (ko) | 2018-06-15 | 2021-04-01 | 플래그쉽 파이어니어링 이노베이션스 브이, 인크. | 세포후 신호전달 인자의 조절을 통한 면역 활성의 증가 |
| EP4349411A3 (en) | 2018-06-20 | 2024-06-19 | Incyte Corporation | Anti-pd-1 antibodies and uses thereof |
| EP3810615A4 (en) | 2018-06-20 | 2022-03-30 | Merck Sharp & Dohme Corp. | ARGINASE INHIBITORS AND METHODS OF USE |
| TWI890661B (zh) | 2018-06-21 | 2025-07-21 | 美商再生元醫藥公司 | 用雙特異性抗CD3xMUC16抗體及抗PD-1抗體治療癌症的方法 |
| WO2020005068A2 (en) | 2018-06-29 | 2020-01-02 | Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis | Gene signatures and method for predicting response to pd-1 antagonists and ctla-4 antagonists, and combination thereof |
| CA3105448A1 (en) | 2018-07-03 | 2020-01-09 | Elstar Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
| SG11202013216RA (en) | 2018-07-05 | 2021-01-28 | Incyte Corp | Fused pyrazine derivatives as a2a / a2b inhibitors |
| WO2020012339A1 (en) | 2018-07-09 | 2020-01-16 | Glaxosmithkline Intellectual Property Development Limited | Chemical compounds |
| JP7617839B2 (ja) | 2018-07-09 | 2025-01-20 | プレシゲン，インコーポレイテッド | 融合構築物およびその使用法 |
| MX2021000309A (es) | 2018-07-10 | 2021-04-12 | Novartis Ag | Derivados de 3-(5-hidroxi-1-oxoisoindolin-2-il)piperidina-2,6-dion a y su uso en el tratamiento de enfermedades dependientes del dedo de zinc 2 de la familia ikaros (ikzf2). |
| AR116109A1 (es) | 2018-07-10 | 2021-03-31 | Novartis Ag | Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos |
| CN112673092B (zh) | 2018-07-11 | 2024-03-29 | 阿克蒂姆治疗有限公司 | 工程化的免疫刺激性细菌菌株及其用途 |
| WO2020014583A1 (en) | 2018-07-13 | 2020-01-16 | Bristol-Myers Squibb Company | Ox-40 agonist, pd-1 pathway inhibitor and ctla-4 inhibitor combination for use in a mehtod of treating a cancer or a solid tumor |
| WO2020015722A1 (en) | 2018-07-19 | 2020-01-23 | Tayu Huaxia Biotech Medical Group Co., Ltd. | Anti-pd-1 antibodies, dosages and uses thereof |
| US20210301020A1 (en) | 2018-07-24 | 2021-09-30 | Amgen Inc. | Combination of lilrb1/2 pathway inhibitors and pd-1 pathway inhibitors |
| CN108948202A (zh) * | 2018-07-25 | 2018-12-07 | 博奥信生物技术（南京）有限公司 | 一种抗人pd1单克隆抗体及其用途 |
| CN109053889B (zh) * | 2018-07-25 | 2019-06-21 | 博奥信生物技术（南京）有限公司 | 一种抗人pd1单克隆抗体及用途 |
| WO2020021465A1 (en) | 2018-07-25 | 2020-01-30 | Advanced Accelerator Applications (Italy) S.R.L. | Method of treatment of neuroendocrine tumors |
| KR20210040080A (ko) | 2018-07-26 | 2021-04-12 | 브리스톨-마이어스 스큅 컴퍼니 | 암의 치료를 위한 lag-3 조합 요법 |
| WO2020021061A1 (en) | 2018-07-26 | 2020-01-30 | Pieris Pharmaceuticals Gmbh | Humanized anti-pd-1 antibodies and uses thereof |
| EP3833383A1 (en) | 2018-08-06 | 2021-06-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treating cancers |
| WO2020030571A1 (en) | 2018-08-06 | 2020-02-13 | Glaxosmithkline Intellectual Property Development Limited | Combinations of a pd-1 antibody and a tlr4 modulator and uses thereof |
| WO2020031107A1 (en) | 2018-08-08 | 2020-02-13 | Glaxosmithkline Intellectual Property Development Limited | Chemical compounds |
| ES2974964T3 (es) | 2018-08-16 | 2024-07-02 | Innate Tumor Immunity Inc | Moduladores de NLRP3 derivados de imidazo[4,5-c]quinolina |
| EP3837245A1 (en) | 2018-08-16 | 2021-06-23 | Innate Tumor Immunity, Inc. | Substitued 4-amino-1h-imidazo[4,5-c]quinoline compounds and improved methods for their preparation |
| CN113038989A (zh) | 2018-08-16 | 2021-06-25 | 先天肿瘤免疫公司 | 咪唑并[4,5-c]喹啉衍生的nlrp3调节剂 |
| EP3837277A4 (en) | 2018-08-17 | 2022-05-11 | Icahn School of Medicine at Mount Sinai | RECOMBINANT NEWCASTLE DISEASE VIRUSES AND THEIR USES IN THE PREVENTION OF RSV DISEASE OR HUMAN METAPNEUMOVIRUS INFECTION |
| EP3843849A1 (en) | 2018-08-27 | 2021-07-07 | Pieris Pharmaceuticals GmbH | Combination therapies comprising cd137/her2 bispecific agents and pd-1 axis inhibitors and uses thereof |
| WO2020044206A1 (en) | 2018-08-29 | 2020-03-05 | Glaxosmithkline Intellectual Property Development Limited | Heterocyclic amides as kinase inhibitors for use in the treatment cancer |
| WO2020044252A1 (en) | 2018-08-31 | 2020-03-05 | Novartis Ag | Dosage regimes for anti-m-csf antibodies and uses thereof |
| TW202031273A (zh) | 2018-08-31 | 2020-09-01 | 美商艾歐凡斯生物治療公司 | 抗ｐｄ－１抗體難治療性之非小細胞肺癌（ｎｓｃｌｃ）病患的治療 |
| WO2020049534A1 (en) | 2018-09-07 | 2020-03-12 | Novartis Ag | Sting agonist and combination therapy thereof for the treatment of cancer |
| KR102846109B1 (ko) | 2018-09-07 | 2025-08-18 | 화이자 인코포레이티드 | 항-αvβ8 항체 및 그의 조성물 및 용도 |
| WO2020053742A2 (en) | 2018-09-10 | 2020-03-19 | Novartis Ag | Anti-hla-hbv peptide antibodies |
| MX2021002742A (es) | 2018-09-11 | 2021-08-11 | Curis Inc | Terapia combinada con un inhibidor de la fosfoinositida 3-quinasa con un resto de unión a zinc. |
| KR20230170813A (ko) | 2018-09-12 | 2023-12-19 | 노파르티스 아게 | 항바이러스 피리도피라진디온 화합물 |
| EP3849606A4 (en) | 2018-09-13 | 2022-06-29 | Merck Sharp & Dohme Corp. | Combination of pd-1 antagonist and lag3 antagonist for treating non-microsatellite instablity-high/proficient mismatch repair colorectal cancer |
| KR20210089146A (ko) | 2018-09-19 | 2021-07-15 | 알파인 이뮨 사이언시즈, 인코포레이티드 | 변이체 cd80 단백질 및 관련 구축물의 방법 및 용도 |
| CA3112599A1 (en) | 2018-09-20 | 2020-03-26 | Iovance Biotherapeutics, Inc. | Expansion of tils from cryopreserved tumor samples |
| JP6800191B2 (ja) * | 2018-09-21 | 2020-12-16 | ベイジーン スウィッツァーランド ゲーエムベーハー | 抗ｐｄ−１抗体並びにその治療及び診断のための使用 |
| US12195544B2 (en) | 2018-09-21 | 2025-01-14 | Harpoon Therapeutics, Inc. | EGFR binding proteins and methods of use |
| CN113286817B (zh) | 2018-09-25 | 2025-01-28 | 哈普恩治疗公司 | Dll3结合蛋白及使用方法 |
| CN113164777B (zh) | 2018-09-27 | 2024-12-13 | 马伦戈治疗公司 | Csf1r/ccr2多特异性抗体 |
| US20210347851A1 (en) | 2018-09-28 | 2021-11-11 | Novartis Ag | Cd19 chimeric antigen receptor (car) and cd22 car combination therapies |
| EP3856779A1 (en) | 2018-09-28 | 2021-08-04 | Novartis AG | Cd22 chimeric antigen receptor (car) therapies |
| IL305106B2 (en) | 2018-09-29 | 2025-08-01 | Novartis Ag | Process of manufacture of a compound for inhibiting the activity of shp2 |
| SG11202103192RA (en) | 2018-10-03 | 2021-04-29 | Xencor Inc | Il-12 heterodimeric fc-fusion proteins |
| EP3864046A1 (en) | 2018-10-09 | 2021-08-18 | Bristol-Myers Squibb Company | Anti-mertk antibodies for treating cancer |
| US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
| TWI855000B (zh) | 2018-10-11 | 2024-09-11 | 日商小野藥品工業股份有限公司 | Ｓｔｉｎｇ促效化合物 |
| MX2021004059A (es) | 2018-10-12 | 2021-09-23 | Xencor Inc | Proteínas de fusión de il-15/il-15ralfa-fc dirigidas a pd-1 y usos de las mismas en terapias combinadas. |
| MX2021004226A (es) * | 2018-10-15 | 2021-07-15 | Five Prime Therapeutics Inc | Terapia combinada contra el cáncer. |
| EP3867409A1 (en) | 2018-10-16 | 2021-08-25 | Novartis AG | Tumor mutation burden alone or in combination with immune markers as biomarkers for predicting response to targeted therapy |
| EP3866812A1 (en) | 2018-10-17 | 2021-08-25 | BioLineRx Ltd. | Treatment of metastatic pancreatic adenocarcinoma |
| US12152019B2 (en) | 2018-10-17 | 2024-11-26 | Merck Sharp & Dohme Llc | Arylalkyl pyrazole compounds as indoleamine 2,3-dioxygenase inhibitors |
| EP3867269A1 (en) | 2018-10-18 | 2021-08-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Combination of a big-h3 antagonist and an immune checkpoint inhibitor for the treatment of solid tumor |
| CA3117016A1 (en) | 2018-10-19 | 2020-04-23 | Bristol-Myers Squibb Company | Combination therapy for melanoma |
| CA3116584A1 (en) | 2018-10-22 | 2020-04-30 | Glaxosmithkline Intellectual Property Development Limited | Dosing |
| CN112912403A (zh) | 2018-10-23 | 2021-06-04 | 百时美施贵宝公司 | 治疗肿瘤的方法 |
| JP2022513400A (ja) | 2018-10-29 | 2022-02-07 | メルサナ セラピューティクス インコーポレイテッド | ペプチド含有リンカーを有するシステイン操作抗体－薬物コンジュゲート |
| TWI844571B (zh) | 2018-10-30 | 2024-06-11 | 丹麥商珍美寶股份有限公司 | 使用抗血管內皮生長因子（ｖｅｇｆ）抗體與抗組織因子（ｔｆ）抗體－藥物共軛體之組合以治療癌症之方法 |
| EP3873532A1 (en) | 2018-10-31 | 2021-09-08 | Novartis AG | Dc-sign antibody drug conjugates |
| PE20211058A1 (es) | 2018-11-01 | 2021-06-07 | Juno Therapeutics Inc | Receptores de antigenos quimericos especificos para el miembro d del grupo 5 de la clase c del receptor acoplado a proteina g (gprc5d) |
| SG11202104188VA (en) | 2018-11-01 | 2021-05-28 | Juno Therapeutics Inc | Methods for treatment using chimeric antigen receptors specific for b-cell maturation antigen |
| EP3873464B1 (en) | 2018-11-01 | 2025-07-30 | Merck Sharp & Dohme LLC | Novel substituted pyrazole compounds as indoleamine 2,3-dioxygenase inhibitors |
| EP3877366A4 (en) | 2018-11-06 | 2022-08-24 | Merck Sharp & Dohme Corp. | NOVEL SUBSTITUTED TRICYCLIC COMPOUNDS AS INDOLAMINE-2,3-DIOXYGENASE INHIBITORS |
| KR20210089215A (ko) | 2018-11-07 | 2021-07-15 | 머크 샤프 앤드 돔 코포레이션 | 항-lag3 항체 및 항-pd-1 항체의 공동-제제 |
| US20220001026A1 (en) | 2018-11-08 | 2022-01-06 | Modernatx, Inc. | Use of mrna encoding ox40l to treat cancer in human patients |
| EP3890773A4 (en) | 2018-11-08 | 2022-11-09 | Orionis Biosciences, Inc. | MODULATION OF DENDRITIC CELL LINES |
| EP3876955A4 (en) | 2018-11-09 | 2022-08-24 | Pierian Biosciences, LLC | METHODS AND COMPOSITIONS FOR DETERMINING THE COMPOSITION OF A TUMOR MICROENVIRONMENT |
| TW202028222A (zh) | 2018-11-14 | 2020-08-01 | 美商Ionis製藥公司 | Foxp3表現之調節劑 |
| PT3880186T (pt) | 2018-11-14 | 2024-05-28 | Regeneron Pharma | Administração intralesional de inibidores de pd-1 para o tratamento do cancro de pele |
| JP7621943B2 (ja) | 2018-11-14 | 2025-01-27 | ドイチェス クレープスフォルシュングスツェントルム シュティフトゥング デス エッフェントリッヒェン レヒツ | がんを治療するための、抗ｃｅａｃａｍ６および抗ｐｄ－１抗体または抗ｐｄ－ｌ１抗体のいずれかの医薬組み合わせ |
| EP3880231A1 (en) | 2018-11-16 | 2021-09-22 | NeoImmuneTech, Inc. | Method of treating a tumor with a combination of il-7 protein and an immune checkpoint inhibitor |
| CA3120118A1 (en) | 2018-11-16 | 2020-05-22 | Juno Therapeutics, Inc. | Methods of dosing engineered t cells for the treatment of b cell malignancies |
| CN113301899A (zh) | 2018-11-16 | 2021-08-24 | 艾科尔公司 | 用于治疗癌症的药物组合 |
| CN113316590B (zh) | 2018-11-16 | 2025-02-28 | 百时美施贵宝公司 | 抗nkg2a抗体及其用途 |
| WO2020106621A1 (en) | 2018-11-19 | 2020-05-28 | Board Of Regents, The University Of Texas System | A modular, polycistronic vector for car and tcr transduction |
| CN113056288A (zh) | 2018-11-20 | 2021-06-29 | 康奈尔大学 | 放射性核素的大环配合物及其在癌症的放射治疗中的应用 |
| WO2020104479A1 (en) | 2018-11-20 | 2020-05-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treating cancers and resistant cancers with anti transferrin receptor 1 antibodies |
| CA3119774A1 (en) | 2018-11-20 | 2020-05-28 | Merck Sharp & Dohme Corp. | Substituted amino triazolopyrimidine and amino triazolopyrazine adenosine receptor antagonists, pharmaceutical compositions and their use |
| US20230183379A1 (en) | 2018-11-20 | 2023-06-15 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Bispecific antibody targeting transferrin receptor 1 and soluble antigen |
| EP3883576B1 (en) | 2018-11-20 | 2025-12-17 | Merck Sharp & Dohme LLC | Substituted amino triazolopyrimidine and amino triazolopyrazine adenosine receptor antagonists, pharmaceutical compositions and their use |
| EP3886842A1 (en) | 2018-11-26 | 2021-10-06 | Debiopharm International SA | Combination treatment of hiv infections |
| EP3888648A4 (en) | 2018-11-27 | 2022-08-10 | ONO Pharmaceutical Co., Ltd. | TREATMENT OF CANCER BY COMBINATION OF IMMUNE CHECKPOINT INHIBITOR AND FOLFIRINOX THERAPY |
| WO2020112581A1 (en) | 2018-11-28 | 2020-06-04 | Merck Sharp & Dohme Corp. | Novel substituted piperazine amide compounds as indoleamine 2, 3-dioxygenase (ido) inhibitors |
| EA202191463A1 (ru) | 2018-11-28 | 2021-10-13 | Борд Оф Риджентс, Дзе Юниверсити Оф Техас Систем | Мультиплексное редактирование генома иммунных клеток для повышения функциональности и устойчивости к подавляющей среде |
| CN113316455A (zh) | 2018-11-29 | 2021-08-27 | 得克萨斯大学体系董事会 | 用于离体扩增自然杀伤细胞的方法及其用途 |
| US20220162705A1 (en) | 2018-11-30 | 2022-05-26 | Gbg Forschungs Gmbh | Method for predicting the response to cancer immunotherapy in cancer patients |
| TW202039496A (zh) | 2018-11-30 | 2020-11-01 | 美商默沙東藥廠 | 做為腺苷受體拮抗劑之9-經取代胺基三唑喹唑啉衍生物、醫藥組合物及其用途 |
| BR112021010353A2 (pt) | 2018-11-30 | 2021-08-31 | Glaxosmithkline Intellectual Property Development Limited | Compostos úteis em terapia hiv |
| DK3886875T3 (da) | 2018-11-30 | 2024-07-29 | Juno Therapeutics Inc | Behandlingsfremgangsmåder under anvendelse af adoptiv celleterapi |
| IL283522B2 (en) | 2018-12-03 | 2025-03-01 | Agensys Inc | Pharmaceutical compositions containing anti-191P4D12 antibody drug conjugates and methods of using them |
| EP3891508A1 (en) | 2018-12-04 | 2021-10-13 | Bristol-Myers Squibb Company | Methods of analysis using in-sample calibration curve by multiple isotopologue reaction monitoring |
| CA3119807A1 (en) | 2018-12-04 | 2020-06-11 | Sumitomo Dainippon Pharma Oncology, Inc. | Cdk9 inhibitors and polymorphs thereof for use as agents for treatment of cancer |
| WO2020115261A1 (en) | 2018-12-07 | 2020-06-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treating melanoma |
| MX2021006831A (es) | 2018-12-11 | 2021-07-02 | Theravance Biopharma R&D Ip Llc | Inhibidores de alk5. |
| WO2020120592A1 (en) | 2018-12-12 | 2020-06-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for predicting and treating melanoma |
| US12358978B2 (en) | 2018-12-13 | 2025-07-15 | Surface Oncology, LLC | Anti-IL-27 antibodies and uses thereof |
| WO2020131598A1 (en) | 2018-12-18 | 2020-06-25 | Merck Sharp & Dohme Corp. | Arginase inhibitors and methods of use |
| CA3123735A1 (en) | 2018-12-19 | 2020-06-25 | Bayer Aktiengesellschaft | Pharmaceutical combination of anti ceacam6 and tim3 antibodies |
| WO2020127411A1 (en) | 2018-12-19 | 2020-06-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treating cancers by immuno-modulation using antibodies against cathespin-d |
| WO2020132646A1 (en) | 2018-12-20 | 2020-06-25 | Xencor, Inc. | Targeted heterodimeric fc fusion proteins containing il-15/il-15ra and nkg2d antigen binding domains |
| WO2020128972A1 (en) | 2018-12-20 | 2020-06-25 | Novartis Ag | Dosing regimen and pharmaceutical combination comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives |
| WO2020127965A1 (en) | 2018-12-21 | 2020-06-25 | Onxeo | New conjugated nucleic acid molecules and their uses |
| BR112021012103A2 (pt) | 2018-12-21 | 2021-09-08 | Aim Immunotech Inc. | Composições e métodos para terapia de câncer |
| WO2020127885A1 (en) | 2018-12-21 | 2020-06-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Compositions for treating cancers and resistant cancers |
| EP4406555A3 (en) | 2018-12-21 | 2024-11-06 | Novartis AG | Antibodies to pmel17 and conjugates thereof |
| WO2020136133A1 (en) | 2018-12-23 | 2020-07-02 | F. Hoffmann-La Roche Ag | Tumor classification based on predicted tumor mutational burden |
| TWI863951B (zh) | 2018-12-27 | 2024-12-01 | 美商安進公司 | 凍乾病毒配製物 |
| JP2022517324A (ja) | 2019-01-03 | 2022-03-08 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 癌を患っている被験者における、ｃｄ８陽性ｔ細胞依存性免疫応答を増強させるための方法及び医薬組成物 |
| SG11202107438WA (en) | 2019-01-09 | 2021-08-30 | Celgene Corp | Pharmaceutical compositions comprising (s)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl) benzyl)piperazin-1-yl)-3-fluorobenzonitrile and methods of using the same |
| CN114394954B (zh) | 2019-01-09 | 2024-04-02 | 细胞基因公司 | 包含氧代异吲哚化合物及其盐的固体形式，以及包含它们的组合物和它们的使用方法 |
| FI3908281T3 (fi) | 2019-01-09 | 2024-10-01 | Celgene Corp | Antiproliferatiivisia yhdisteitä ja toisia aktiivisia aineita käytettäväksi multippelin myelooman hoidossa |
| CN111423510B (zh) | 2019-01-10 | 2024-02-06 | 迈威(上海)生物科技股份有限公司 | 重组抗人pd-1抗体及其应用 |
| JP7506080B2 (ja) | 2019-01-14 | 2024-06-25 | イネイト・テューマー・イミュニティ・インコーポレイテッド | Ｎｌｒｐ３モジュレーター |
| WO2020150113A1 (en) | 2019-01-14 | 2020-07-23 | Innate Tumor Immunity, Inc. | Substituted quinazolines as nlrp3 modulators, for use in the treatment of cancer |
| WO2020150114A1 (en) | 2019-01-14 | 2020-07-23 | Innate Tumor Immunity, Inc. | Heterocyclic nlrp3 modulators, for use in the treatment of cancer |
| EP3911641A1 (en) | 2019-01-14 | 2021-11-24 | Innate Tumor Immunity, Inc. | Nlrp3 modulators |
| MX2021008546A (es) | 2019-01-18 | 2021-11-12 | Dracen Pharmaceuticals Inc | Terapia combinada con un profarmaco de 6-diazo-5-oxo-l-norleucina (don) y un inhibidor de puntos de control inmunologicos. |
| AU2020210614A1 (en) | 2019-01-21 | 2021-08-26 | Sanofi | Therapeutic RNA and anti-PD1 antibodies for advanced stage solid tumor cancers |
| TWI894135B (zh) | 2019-01-25 | 2025-08-21 | 德商百靈佳殷格翰國際股份有限公司 | 編碼ccl21之重組棒狀病毒 |
| AR119683A1 (es) | 2019-01-29 | 2022-01-05 | Juno Therapeutics Inc | Anticuerpos y receptores de antígeno quimérico específicos para receptor huérfano 1 similar a receptor de tirosina quinasa (ror1) |
| TWI829857B (zh) | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶 |
| CN120468425A (zh) | 2019-01-30 | 2025-08-12 | 国家医疗保健研究所 | 用于鉴定患有癌症的受试者是否将获得对免疫检查点抑制剂的应答的方法和组合物 |
| WO2020160365A1 (en) | 2019-02-01 | 2020-08-06 | Glaxosmithkline Intellectual Property Development Limited | Belantamab mafodotin in combination with pembrolizumab for treating cancer |
| EP3921031A1 (en) | 2019-02-04 | 2021-12-15 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods and compositions for modulating blood-brain barrier |
| TW202045172A (zh) | 2019-02-12 | 2020-12-16 | 瑞士商諾華公司 | 包含tno155和pd-1抑制劑之藥物組合 |
| NZ778055A (en) | 2019-02-12 | 2025-11-28 | Sumitomo Pharma America Inc | Formulations comprising heterocyclic protein kinase inhibitors |
| WO2020165370A1 (en) | 2019-02-13 | 2020-08-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for selecting a cancer treatment in a subject suffering from cancer |
| AU2020222346B2 (en) | 2019-02-15 | 2021-12-09 | Novartis Ag | Substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
| US20220107320A1 (en) | 2019-02-15 | 2022-04-07 | Incelldx, Inc. | Assaying Bladder-Associated Samples, Identifying and Treating Bladder-Associated Neoplasia, and Kits for Use Therein |
| MX2021009763A (es) | 2019-02-15 | 2021-09-08 | Novartis Ag | Derivados de 3-(1-oxo-5-(piperidin-4-il)isoindolin-2-il)piperidina -2,6-diona y usos de los mismos. |
| US11384083B2 (en) | 2019-02-15 | 2022-07-12 | Incyte Corporation | Substituted spiro[cyclopropane-1,5′-pyrrolo[2,3-d]pyrimidin]-6′(7′h)-ones as CDK2 inhibitors |
| KR20210139269A (ko) | 2019-02-15 | 2021-11-22 | 인사이트 코포레이션 | 사이클린-의존성 키나아제 2 바이오마커 및 이들의 용도 |
| ES2980469T3 (es) | 2019-02-19 | 2024-10-01 | Turnstone Biologics Corp | Métodos para producir linfocitos T autólogos útiles para tratar cánceres y composiciones de los mismos |
| CN119039441A (zh) | 2019-02-21 | 2024-11-29 | 马伦戈治疗公司 | 与nkp30结合的抗体分子及其用途 |
| WO2020172571A1 (en) | 2019-02-21 | 2020-08-27 | Elstar Therapeutics, Inc. | Multifunctional molecules that bind to t cell related cancer cells and uses thereof |
| BR112021015323A2 (pt) | 2019-02-27 | 2021-10-05 | Ionis Pharmaceuticals, Inc. | Moduladores de expressão de malat1 |
| JP2022521800A (ja) | 2019-02-28 | 2022-04-12 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 皮膚がんを治療するためのｐｄ－１阻害剤の投与 |
| WO2020180864A1 (en) | 2019-03-05 | 2020-09-10 | Amgen Inc. | Use of oncolytic viruses for the treatment of cancer |
| US11472791B2 (en) | 2019-03-05 | 2022-10-18 | Incyte Corporation | Pyrazolyl pyrimidinylamine compounds as CDK2 inhibitors |
| US12187792B2 (en) | 2019-03-06 | 2025-01-07 | Regeneron Pharmaceuticals, Inc. | IL-4/IL-13 pathway inhibitors for enhanced efficacy in treating cancer |
| WO2020185532A1 (en) | 2019-03-08 | 2020-09-17 | Incyte Corporation | Methods of treating cancer with an fgfr inhibitor |
| US12358986B2 (en) | 2019-03-13 | 2025-07-15 | Merck Sharp & Dohme Llc | Anti-cancer combination therapies comprising CTLA-4 and PD-1 blocking agents |
| WO2020183011A1 (en) | 2019-03-14 | 2020-09-17 | Institut Curie | Htr1d inhibitors and uses thereof in the treatment of cancer |
| US20220184121A1 (en) | 2019-03-18 | 2022-06-16 | The Regents Of The University Of California | Augmentation of t-cell activation by oscillatory forces and engineered antigen-presenting cells |
| CN120131907A (zh) | 2019-03-19 | 2025-06-13 | 瓦尔希伯伦私人肿瘤研究基金会 | 采用Omomyc和结合PD-1或CTLA-4的抗体治疗癌症的联合疗法 |
| US11793802B2 (en) | 2019-03-20 | 2023-10-24 | Sumitomo Pharma Oncology, Inc. | Treatment of acute myeloid leukemia (AML) with venetoclax failure |
| JP7547360B2 (ja) | 2019-03-22 | 2024-09-09 | スミトモ ファーマ オンコロジー， インコーポレイテッド | Ｐｋｍ２モジュレーターを含む組成物およびそれを使用する処置の方法 |
| MX2021011753A (es) | 2019-03-26 | 2022-01-31 | Univ Michigan Regents | Degradadores de moleculas peque?as de stat3. |
| WO2020198676A1 (en) | 2019-03-28 | 2020-10-01 | Bristol-Myers Squibb Company | Methods of treating tumor |
| US20220041733A1 (en) | 2019-03-28 | 2022-02-10 | Bristol-Myers Squibb Company | Methods of treating tumor |
| TW202102543A (zh) | 2019-03-29 | 2021-01-16 | 美商安進公司 | 溶瘤病毒在癌症新輔助療法中之用途 |
| US11919904B2 (en) | 2019-03-29 | 2024-03-05 | Incyte Corporation | Sulfonylamide compounds as CDK2 inhibitors |
| CN114126637A (zh) | 2019-03-29 | 2022-03-01 | 居里研究所 | 具有经修饰的生物活性的白介素-2变体 |
| US20220185831A1 (en) | 2019-03-29 | 2022-06-16 | The Regents Of The University Of Michigan | Stat3 protein degraders |
| EP3946437B1 (en) | 2019-03-29 | 2025-11-19 | H. Lee Moffitt Cancer Center and Research Institute, Inc. | Ex vivo methods for producing a t cell therapeutic and related compositions and methods |
| MX2021011654A (es) | 2019-04-03 | 2022-02-21 | Targimmune Therapeutics Ag | Inmunoterapia para el tratamiento del cancer. |
| US12281109B2 (en) | 2019-04-04 | 2025-04-22 | Merck Sharp & Dohme Llc | Inhibitors of histone deacetylase-3 useful for the treatment of cancer, inflammation, neurodegeneration diseases and diabetes |
| AR118619A1 (es) * | 2019-04-10 | 2021-10-20 | Bio Thera Solutions Ltd | Anticuerpos de unión a pd-1 |
| WO2020207961A1 (en) * | 2019-04-11 | 2020-10-15 | Bayer Aktiengesellschaft | Combinations of anti-ildr2 antibodies and pd-1 antagonists |
| WO2020208612A1 (en) | 2019-04-12 | 2020-10-15 | Vascular Biogenics Ltd. | Methods of anti-tumor therapy |
| EP3725370A1 (en) | 2019-04-19 | 2020-10-21 | ImmunoBrain Checkpoint, Inc. | Modified anti-pd-l1 antibodies and methods and uses for treating a neurodegenerative disease |
| CN113811329B (zh) | 2019-04-19 | 2025-10-14 | 天科雅生物科技有限公司 | 抗pd-1抗体和其用途 |
| EP3963109A1 (en) | 2019-04-30 | 2022-03-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treating melanoma |
| WO2020223558A1 (en) | 2019-05-01 | 2020-11-05 | Incyte Corporation | Tricyclic amine compounds as cdk2 inhibitors |
| WO2020223469A1 (en) | 2019-05-01 | 2020-11-05 | Incyte Corporation | N-(1-(methylsulfonyl)piperidin-4-yl)-4,5-di hydro-1h-imidazo[4,5-h]quinazolin-8-amine derivatives and related compounds as cyclin-dependent kinase 2 (cdk2) inhibitors for treating cancer |
| WO2020227159A2 (en) | 2019-05-03 | 2020-11-12 | Flagship Pioneering Innovations V, Inc. | Methods of modulating immune activity |
| EP3965816A1 (en) | 2019-05-06 | 2022-03-16 | MedImmune Limited | Combination of monalizumab, durvalumab, chemotherapy and bevacizumab or cetuximab for the treatment of colorectal cancer |
| CN114096278A (zh) | 2019-05-07 | 2022-02-25 | 英谬免疫股份有限公司 | 通过体外单采血增加对检查点抑制剂的反应 |
| US12492380B2 (en) | 2019-05-09 | 2025-12-09 | FUJIFILM Cellular Dynamics, Inc. | Methods for the production of hepatocytes |
| SG11202111262XA (en) | 2019-05-13 | 2021-11-29 | Regeneron Pharma | Combination of pd-1 inhibitors and lag-3 inhibitors for enhanced efficacy in treating cancer |
| JP2022531978A (ja) | 2019-05-15 | 2022-07-12 | ネオティーエックス セラピューティクス リミテッド | 癌治療 |
| CN114302875A (zh) | 2019-05-16 | 2022-04-08 | 斯汀塞拉股份有限公司 | 氧代吖啶基乙酸衍生物及使用方法 |
| EP3969452A1 (en) | 2019-05-16 | 2022-03-23 | Stingthera, Inc. | Benzo[b][1,8]naphthyridine acetic acid derivatives and methods of use |
| WO2020236667A1 (en) | 2019-05-17 | 2020-11-26 | Gb006, Inc. | Methods of treating cancer |
| JP2022532766A (ja) | 2019-05-17 | 2022-07-19 | キャンサー プリベンション ファーマシューティカルズ，インコーポレイテッド | 家族性腺腫性ポリポーシスを処置するための方法 |
| IL266728B (en) | 2019-05-19 | 2020-11-30 | Yeda Res & Dev | Identification of recurrent mutant neopeptides |
| KR20220010525A (ko) | 2019-05-20 | 2022-01-25 | 메사추세츠 인스티튜트 오브 테크놀로지 | 보론산 에스테르 전구약물 및 그의 용도 |
| AU2020281535A1 (en) | 2019-05-24 | 2022-01-27 | Merck Patent Gmbh | Combination therapies using CDK inhibitors |
| CN114174537A (zh) | 2019-05-30 | 2022-03-11 | 百时美施贵宝公司 | 细胞定位特征和组合疗法 |
| WO2020243568A1 (en) | 2019-05-30 | 2020-12-03 | Bristol-Myers Squibb Company | Methods of identifying a subject suitable for an immuno-oncology (i-o) therapy |
| KR20220016156A (ko) | 2019-05-30 | 2022-02-08 | 브리스톨-마이어스 스큅 컴퍼니 | 면역-종양학 요법에의 적합성을 위한 다종양 유전자 시그너쳐 |
| CN114206355A (zh) | 2019-06-03 | 2022-03-18 | 芝加哥大学 | 用靶向癌症的佐剂治疗癌症的方法和组合物 |
| BR112021024438A2 (pt) | 2019-06-03 | 2022-02-15 | Univ Chicago | Métodos e composições para tratar câncer com carreadores de fármaco de ligação de colágeno |
| US11246906B2 (en) | 2019-06-11 | 2022-02-15 | Alkermes Pharma Ireland Limited | Compositions and methods for subcutaneous administration of cancer immunotherapy |
| WO2020252353A1 (en) | 2019-06-12 | 2020-12-17 | Vanderbilt University | Amino acid transport inhibitors and the uses thereof |
| US20220265590A1 (en) | 2019-06-12 | 2022-08-25 | Vanderbilt University | Dibenzylamines as amino acid transport inhibitors |
| CA3138834A1 (en) | 2019-06-14 | 2020-12-17 | Tilt Biotherapeutics Oy | Oncolytic adenovirus and checkpoint inhibitor combination therapy |
| JP2022537324A (ja) | 2019-06-18 | 2022-08-25 | ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー | Ｂ型肝炎ウイルス（ｈｂｖ）ワクチンおよび抗ｐｄ－１抗体の組合せ |
| KR20220041080A (ko) | 2019-06-18 | 2022-03-31 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | B형 간염 바이러스(hbv) 백신 및 항-pd-1 또는 항-pc-l1 항체의 조합 |
| EP3990635A1 (en) | 2019-06-27 | 2022-05-04 | Rigontec GmbH | Design method for optimized rig-i ligands |
| JP2022538284A (ja) | 2019-06-27 | 2022-09-01 | ザ ジョージ ワシントン ユニバーシティ， ア コングレッショナリー チャータード ノット－フォー－プロフィット コーポレイション | Ｈｄａｃ６活性化マクロファージ、その組成物および使用 |
| BR112021026832A2 (pt) | 2019-07-02 | 2022-05-10 | Hutchinson Fred Cancer Res | Vetores ad35 recombinantes e aprimoramentos da terapia gênica relacionada |
| US11529350B2 (en) | 2019-07-03 | 2022-12-20 | Sumitomo Pharma Oncology, Inc. | Tyrosine kinase non-receptor 1 (TNK1) inhibitors and uses thereof |
| KR20220030956A (ko) | 2019-07-05 | 2022-03-11 | 오노 야꾸힝 고교 가부시키가이샤 | Pd-1/cd3 이중 특이성 단백질에 의한 혈액암 치료 |
| US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| WO2021011713A1 (en) | 2019-07-16 | 2021-01-21 | The Regents Of The University Of Michigan | Imidazopyrimidines as eed inhibitors and the use thereof |
| GB201910304D0 (en) | 2019-07-18 | 2019-09-04 | Ctxt Pty Ltd | Compounds |
| GB201910305D0 (en) | 2019-07-18 | 2019-09-04 | Ctxt Pty Ltd | Compounds |
| US12036204B2 (en) | 2019-07-26 | 2024-07-16 | Eisai R&D Management Co., Ltd. | Pharmaceutical composition for treating tumor |
| US11083705B2 (en) | 2019-07-26 | 2021-08-10 | Eisai R&D Management Co., Ltd. | Pharmaceutical composition for treating tumor |
| EP4004548B1 (en) | 2019-07-29 | 2026-01-14 | Yeda Research and Development Co. Ltd | Methods of treating and diagnosing lung cancer |
| EP4003523A4 (en) * | 2019-07-30 | 2023-09-06 | Merck Sharp & Dohme LLC | ANTI-PD-1/LAG3/TIGIT TRISPECIFIC ANTIBODIES AND ANTI-PD-1/LAG3 BISPECIFIC ANTIBODIES |
| EP4007758A1 (en) | 2019-08-02 | 2022-06-08 | Mersana Therapeutics, Inc. | Bis-[n-((5-carbamoyl)-1h-benzo[d]imidazol-2-yl)-pyrazol-5-carboxamide] derivatives and related compounds as sting (stimulator of interferon genes) agonists for the treatment of cancer |
| JP2022542437A (ja) | 2019-08-02 | 2022-10-03 | ランティオペプ ベスローテン ヴェンノーツハップ | 癌の処置に用いるアンジオテンシン２型（ａｔ２）受容体アゴニスト |
| BR112022002098A2 (pt) | 2019-08-05 | 2022-04-12 | Nat Cancer Ct | Biomarcadores para determinar a eficácia de inibidores da via de sinalização imune |
| WO2021024020A1 (en) | 2019-08-06 | 2021-02-11 | Astellas Pharma Inc. | Combination therapy involving antibodies against claudin 18.2 and immune checkpoint inhibitors for treatment of cancer |
| JP7771749B2 (ja) | 2019-08-08 | 2025-11-18 | 小野薬品工業株式会社 | 二重特異性タンパク質 |
| WO2021030251A1 (en) | 2019-08-12 | 2021-02-18 | Purinomia Biotech, Inc. | Methods and compositions for promoting and potentiating t-cell mediated immune responses through adcc targeting of cd39 expressing cells |
| CR20220066A (es) | 2019-08-14 | 2022-11-28 | Incyte Corp | Compuestos de imidazolil pirimidinilamina como inhibidores de cdk2 |
| GB201912107D0 (en) | 2019-08-22 | 2019-10-09 | Amazentis Sa | Combination |
| KR102231974B1 (ko) * | 2019-08-23 | 2021-03-25 | 한국과학기술원 | 사람의 프로그램된 세포사멸 단백질(pd-1)에 선택적으로 결합하는 신규한 폴리펩티드 및 이의 용도 |
| US20220305048A1 (en) | 2019-08-26 | 2022-09-29 | Dana-Farber Cancer Institute, Inc. | Use of heparin to promote type 1 interferon signaling |
| WO2021041664A1 (en) | 2019-08-27 | 2021-03-04 | The Regents Of The University Of Michigan | Cereblon e3 ligase inhibitors |
| PE20221151A1 (es) | 2019-08-30 | 2022-07-18 | Agenus Inc | Anticuerpos anti-cd96 y sus metodos de uso |
| WO2021048292A1 (en) | 2019-09-11 | 2021-03-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treating melanoma |
| US12121565B2 (en) | 2019-09-13 | 2024-10-22 | Duke University | Methods of treatment of specific cancers with NLRP3 inhibitors and anti-PD1/PD-L1 antibodies |
| EP4031178A1 (en) | 2019-09-16 | 2022-07-27 | Surface Oncology, Inc. | Anti-cd39 antibody compositions and methods |
| JP2022549227A (ja) | 2019-09-17 | 2022-11-24 | バイアル－アールアンドディー インベストメンツ ソシエダッド アノニマ | 医学的障害の治療における使用のための置換された飽和および不飽和ｎ－複素環式カルボキサミドおよび関連化合物 |
| CA3151022A1 (en) | 2019-09-17 | 2021-03-25 | Bial - R&D Investments, S.A. | Substituted n-heterocyclic carboxamides as acid ceramidase inhibitors and their use as medicaments |
| EP4031531A1 (en) | 2019-09-17 | 2022-07-27 | Bial-R&D Investments, S.A. | Substituted imidazole carboxamides and their use in the treatment of medical disorders |
| ES2975528T3 (es) | 2019-09-18 | 2024-07-08 | Lamkap Bio Alpha AG | Anticuerpos biespecíficos contra ceacam5 y cd3 |
| JP2022548881A (ja) | 2019-09-18 | 2022-11-22 | ノバルティス アーゲー | Ｅｎｔｐｄ２抗体、組合せ療法並びに抗体及び組合せ療法を使用する方法 |
| TW202124446A (zh) | 2019-09-18 | 2021-07-01 | 瑞士商諾華公司 | 與ｅｎｔｐｄ２抗體之組合療法 |
| PE20221416A1 (es) | 2019-09-18 | 2022-09-20 | Novartis Ag | Proteinas de fusion nkg2d y sus usos |
| CN115023267A (zh) | 2019-09-19 | 2022-09-06 | 密歇根大学董事会 | 螺环雄激素受体蛋白质降解剂 |
| BR112022004316A2 (pt) | 2019-09-22 | 2022-06-21 | Bristol Myers Squibb Co | Caracterização espacial quantitativa para terapia de antagonista lag-3 |
| US11890285B2 (en) | 2019-09-24 | 2024-02-06 | Mirati Therapeutics, Inc. | Combination therapies |
| KR20220069964A (ko) | 2019-09-25 | 2022-05-27 | 씨젠 인크. | 조혈암의 치료를 위한 항-cd30 adc, 항-pd-1 및 화학치료제 조합 |
| JP2022549854A (ja) | 2019-09-25 | 2022-11-29 | サーフィス オンコロジー インコーポレイテッド | 抗ｉｌ－２７抗体及びその使用 |
| CA3152263A1 (en) | 2019-09-25 | 2021-04-01 | Julia SANTUCCI PEREIRA DEL BUONO | Composite biomarker for cancer therapy |
| WO2021061898A1 (en) | 2019-09-26 | 2021-04-01 | Novartis Ag | Antiviral pyrazolopyridinone compounds |
| PH12022550671A1 (en) | 2019-09-27 | 2023-05-29 | Glaxosmithkline Ip Dev Ltd | Antigen binding proteins |
| MX2022003578A (es) | 2019-09-30 | 2022-05-30 | Incyte Corp | Compuestos de pirido[3,2-d]pirimidina como inmunomoduladores. |
| AU2020358726A1 (en) | 2019-10-01 | 2022-04-07 | Silverback Therapeutics, Inc. | Combination therapy with immune stimulatory conjugates |
| WO2021067374A1 (en) | 2019-10-01 | 2021-04-08 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| US20220354811A1 (en) | 2019-10-03 | 2022-11-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for modulating macrophages polarization |
| CN115916233A (zh) | 2019-10-03 | 2023-04-04 | Xencor股份有限公司 | 靶向IL-12异源二聚体Fc融合蛋白 |
| GB201914747D0 (en) | 2019-10-11 | 2019-11-27 | Ultrahuman Eight Ltd | PD1 and vegfr2 dual-binding agents |
| TW202128757A (zh) | 2019-10-11 | 2021-08-01 | 美商建南德克公司 | 具有改善之特性的 PD-1 標靶 IL-15/IL-15Rα FC 融合蛋白 |
| CN119930610A (zh) | 2019-10-11 | 2025-05-06 | 因赛特公司 | 作为cdk2抑制剂的双环胺 |
| JOP20220083A1 (ar) | 2019-10-14 | 2023-01-30 | Incyte Corp | حلقات غير متجانسة ثنائية الحلقة كمثبطات لـ fgfr |
| US12380963B2 (en) | 2019-10-14 | 2025-08-05 | The Medical College Of Wisconsin, Inc. | Gene expression signature of hyperprogressive disease (HPD) in patients after anti-PD-1 immunotherapy |
| US11566028B2 (en) | 2019-10-16 | 2023-01-31 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| US20240301497A1 (en) | 2019-10-17 | 2024-09-12 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for diagnosing nasal intestinal type adenocarcinomas |
| MX2022004766A (es) | 2019-10-21 | 2022-05-16 | Novartis Ag | Terapias combinadas con venetoclax e inhibidores de tim-3. |
| KR20220087498A (ko) | 2019-10-21 | 2022-06-24 | 노파르티스 아게 | Tim-3 억제제 및 그의 용도 |
| WO2021078910A1 (en) | 2019-10-22 | 2021-04-29 | Institut Curie | Immunotherapy targeting tumor neoantigenic peptides |
| WO2021081353A1 (en) | 2019-10-23 | 2021-04-29 | Checkmate Pharmaceuticals, Inc. | Synthetic rig-i-like receptor agonists |
| JPWO2021079958A1 (enExample) | 2019-10-25 | 2021-04-29 | ||
| NL2024108B1 (en) | 2019-10-26 | 2021-07-19 | Vitroscan B V | Methods and apparatus for measuring immune-cell mediated anti-tumoroid responses |
| PH12022551030A1 (en) | 2019-10-28 | 2023-04-24 | Shanghai Inst Materia Medica Cas | Five-membered heterocyclic oxocarboxylic acid compound and medical use thereof |
| WO2021083959A1 (en) | 2019-10-29 | 2021-05-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treating uveal melanoma |
| TW202137984A (zh) | 2019-10-29 | 2021-10-16 | 日商衛材R&D企管股份有限公司 | 用於治療癌症之PD-1拮抗劑、VEGFR/FGFR/RET酪胺酸激酶抑制劑及CBP/β-連環蛋白抑制劑之組合 |
| WO2021087458A2 (en) | 2019-11-02 | 2021-05-06 | Board Of Regents, The University Of Texas System | Targeting nonsense-mediated decay to activate p53 pathway for the treatment of cancer |
| US20220387529A1 (en) | 2019-11-04 | 2022-12-08 | Duke University | Treatment for primary and metastatic cancer |
| AU2020379680A1 (en) | 2019-11-05 | 2022-05-26 | Celgene Corporation | Combination therapy with 2-(4-chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl) methyl)-2,2-difluoroacetamide |
| KR20220092578A (ko) | 2019-11-05 | 2022-07-01 | 브리스톨-마이어스 스큅 컴퍼니 | M-단백질 검정 및 이의 용도 |
| WO2021092221A1 (en) | 2019-11-06 | 2021-05-14 | Bristol-Myers Squibb Company | Methods of identifying a subject with a tumor suitable for a checkpoint inhibitor therapy |
| WO2021092220A1 (en) | 2019-11-06 | 2021-05-14 | Bristol-Myers Squibb Company | Methods of identifying a subject with a tumor suitable for a checkpoint inhibitor therapy |
| MX2022004501A (es) | 2019-11-07 | 2022-05-06 | Oncxerna Therapeutics Inc | Clasificacion de microambientes tumorales. |
| AU2020380732A1 (en) | 2019-11-07 | 2022-06-02 | Genmab A/S | Methods of treating cancer with a combination of an anti-pd-1 antibody and an anti-tissue factor antibody-drug conjugate |
| KR20220093349A (ko) | 2019-11-08 | 2022-07-05 | 브리스톨-마이어스 스큅 컴퍼니 | 흑색종에 대한 lag-3 길항제 요법 |
| IL292524A (en) | 2019-11-11 | 2022-06-01 | Incyte Corp | Salts and crystalline forms of a pd-1/pd-l1 inhibitor |
| TWI895295B (zh) | 2019-11-12 | 2025-09-01 | 美商方得生醫療公司 | 偵測編碼新生抗原之融合基因之方法 |
| US20220395553A1 (en) | 2019-11-14 | 2022-12-15 | Cohbar, Inc. | Cxcr4 antagonist peptides |
| WO2021102343A1 (en) | 2019-11-22 | 2021-05-27 | Sumitomo Dainippon Pharma Oncology, Inc. | Solid dose pharmaceutical composition |
| EP3824954A1 (en) | 2019-11-22 | 2021-05-26 | Centre National de la Recherche Scientifique | Device, apparatus and method for minibeam radiation therapy |
| CN114728941A (zh) | 2019-11-22 | 2022-07-08 | 施万生物制药研发Ip有限责任公司 | 作为alk5抑制剂的经取代的1,5-萘啶或喹啉 |
| JP2023503161A (ja) | 2019-11-26 | 2023-01-26 | ノバルティス アーゲー | Ｃｄ１９及びｃｄ２２キメラ抗原受容体及びその使用 |
| US20230032934A1 (en) | 2019-11-27 | 2023-02-02 | Myst Therapeutics, Llc | Method of producing tumor-reactive t cell composition using modulatory agents |
| WO2021106978A1 (ja) | 2019-11-27 | 2021-06-03 | サイトリミック株式会社 | 医薬組成物 |
| EP3831849A1 (en) | 2019-12-02 | 2021-06-09 | LamKap Bio beta AG | Bispecific antibodies against ceacam5 and cd47 |
| PE20221504A1 (es) | 2019-12-04 | 2022-09-30 | Incyte Corp | Derivados de un inhibidor de fgfr |
| EP4069696A1 (en) | 2019-12-04 | 2022-10-12 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| WO2021113644A1 (en) | 2019-12-05 | 2021-06-10 | Multivir Inc. | Combinations comprising a cd8+ t cell enhancer, an immune checkpoint inhibitor and radiotherapy for targeted and abscopal effects for the treatment of cancer |
| US20230074558A1 (en) | 2019-12-06 | 2023-03-09 | Mersana Therapeutics, Inc. | Dimeric compounds as sting agonists |
| MX2022006891A (es) | 2019-12-09 | 2022-09-09 | Seagen Inc | Terapia combinada con liv1-adc y antagonista de pd-1. |
| AU2020402369A1 (en) | 2019-12-13 | 2022-07-14 | Samsung Bioepis Co., Ltd. | Stable anti-PD-1 antibody pharmaceutical preparation |
| MX2022007438A (es) | 2019-12-16 | 2022-07-19 | Bayer Ag | Combinacion de inhibidores de ahr. |
| US20220396577A1 (en) | 2019-12-17 | 2022-12-15 | Merck Sharp & Dohme Llc | Novel substituted 1,3-8-triazaspiro[4,5] decane-2,4-dione compounds as indoleamine 2,3-dioxygenase (ido) and/or tryptophan 2,3-dioxygenase (tdo) inhibitors |
| US20230114107A1 (en) | 2019-12-17 | 2023-04-13 | Flagship Pioneering Innovations V, Inc. | Combination anti-cancer therapies with inducers of iron-dependent cellular disassembly |
| WO2021119753A1 (en) | 2019-12-18 | 2021-06-24 | Ctxt Pty Limited | Compounds |
| KR20220118481A (ko) | 2019-12-19 | 2022-08-25 | 브리스톨-마이어스 스큅 컴퍼니 | Dgk 억제제 및 체크포인트 길항제의 조합물 |
| EP4076508A1 (en) | 2019-12-19 | 2022-10-26 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and vaccine compositions to treat cancers |
| WO2021121373A1 (zh) * | 2019-12-20 | 2021-06-24 | 广东菲鹏制药股份有限公司 | 抗人程序死亡因子-1单克隆抗体 |
| IL293834A (en) | 2019-12-20 | 2022-08-01 | Novartis Ag | Combination of anti tim-3 antibody mbg453 and anti tgf-beta antibody nis793, with or without decitabine or the anti pd-1 antibody spartalizumab, for treating myelofibrosis and myelodysplastic syndrome |
| EP4084821A4 (en) | 2020-01-03 | 2024-04-24 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to cd33 and uses thereof |
| JP2023509708A (ja) | 2020-01-03 | 2023-03-09 | マレンゴ・セラピューティクス，インコーポレーテッド | 抗ｔｃｒ抗体分子およびその使用 |
| WO2021138512A1 (en) | 2020-01-03 | 2021-07-08 | Incyte Corporation | Combination therapy comprising a2a/a2b and pd-1/pd-l1 inhibitors |
| WO2021141977A1 (en) | 2020-01-07 | 2021-07-15 | Board Of Regents, The University Of Texas System | Improved human methyl thioadenosine/adenosine depleting enzyme variants for cancer therapy |
| EP4087583A4 (en) | 2020-01-07 | 2024-01-24 | Merck Sharp & Dohme LLC | Arginase inhibitors and methods of use |
| WO2021142203A1 (en) | 2020-01-10 | 2021-07-15 | Innate Tumor Immunity, Inc. | Nlrp3 modulators |
| US12012409B2 (en) | 2020-01-15 | 2024-06-18 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| KR20220128389A (ko) | 2020-01-17 | 2022-09-20 | 노파르티스 아게 | 골수이형성 증후군 또는 만성 골수단핵구성 백혈병을 치료하는데 사용하기 위한 tim-3 억제제 및 저메틸화제를 포함하는 조합물 |
| US20230076415A1 (en) | 2020-01-17 | 2023-03-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treating melanoma |
| EP4096789A4 (en) | 2020-01-29 | 2023-10-11 | Board of Regents, The University of Texas System | USE OF POZIOTINIB TO TREAT CANCER WITH NRG1 FUSIONS |
| JP2023513006A (ja) | 2020-01-29 | 2023-03-30 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | Ｎｒｇ１融合体を有するがんの治療のためのｅｇｆｒ／ｈｅｒ２チロシンキナーゼインヒビターおよび／またはｈｅｒ２／ｈｅｒ３抗体の使用 |
| KR20210097882A (ko) | 2020-01-30 | 2021-08-10 | 삼성바이오에피스 주식회사 | 안정한 항-pd-1 항체 약제학적 제제 |
| WO2021152548A1 (en) | 2020-01-30 | 2021-08-05 | Benitah Salvador Aznar | Combination therapy for treatment of cancer and cancer metastasis |
| US20230072528A1 (en) | 2020-02-05 | 2023-03-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for discontinuing a treatment with a tyrosine kinase inhibitor (tki) |
| US20230087600A1 (en) | 2020-02-06 | 2023-03-23 | Bristol-Myers Squibb Company | Il-10 and uses thereof |
| EP4107173A1 (en) | 2020-02-17 | 2022-12-28 | Board of Regents, The University of Texas System | Methods for expansion of tumor infiltrating lymphocytes and use thereof |
| JP2023516195A (ja) | 2020-02-26 | 2023-04-18 | バイオグラフ ５５，インク． | Ｃ１９ ｃ３８二特異性抗体 |
| EP4110799B1 (en) | 2020-02-27 | 2024-11-06 | Turnstone Biologics Corp. | Methods for ex vivo enrichment and expansion of tumor reactive t cells and related compositions thereof |
| CA3173356A1 (en) | 2020-02-28 | 2021-09-02 | Novartis Ag | A triple pharmaceutical combination comprising dabrafenib, an erk inhibitor and a raf inhibitor or a pd-1 inhibitor. |
| WO2021171264A1 (en) | 2020-02-28 | 2021-09-02 | Novartis Ag | Dosing of a bispecific antibody that binds cd123 and cd3 |
| EP4110955A1 (en) | 2020-02-28 | 2023-01-04 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for diagnosing, prognosing and managing treatment of breast cancer |
| US20230085724A1 (en) | 2020-03-05 | 2023-03-23 | Neotx Therapeutics Ltd. | Methods and compositions for treating cancer with immune cells |
| US20230114276A1 (en) * | 2020-03-06 | 2023-04-13 | Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis | Modulating anti-tumor immunity |
| CN115768465A (zh) | 2020-03-06 | 2023-03-07 | Ona疗法有限公司 | 抗cd36抗体及其治疗癌症的用途 |
| AU2021230575A1 (en) | 2020-03-06 | 2022-10-20 | Celgene Quanticel Research, Inc. | Combination of an LSD-1 inhibitor and nivolumab for use in treating SCLC or sqNSCLC |
| PH12022552347A1 (en) | 2020-03-06 | 2024-01-29 | Incyte Corp | Combination therapy comprising axl/mer and pd-1/pd-l1 inhibitors |
| EP3878446A1 (en) | 2020-03-09 | 2021-09-15 | Universite De Geneve | Hsd11b1 inhibitors for use in immunotherapy and uses thereof |
| WO2021183318A2 (en) | 2020-03-09 | 2021-09-16 | President And Fellows Of Harvard College | Methods and compositions relating to improved combination therapies |
| US20230119066A1 (en) | 2020-03-23 | 2023-04-20 | Bristol-Myers Squibb Company | Anti-ccr8 antibodies for treating cancer |
| WO2021195481A1 (en) | 2020-03-26 | 2021-09-30 | The Regents Of The University Of Michigan | Small molecule stat protein degraders |
| CA3172449A1 (en) | 2020-03-27 | 2021-09-30 | Erik Hans MANTING | Ex vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy |
| AU2021250709A1 (en) | 2020-03-30 | 2022-10-13 | Trizell Ltd. | Compositions and methods for treating cancer |
| CN115443269A (zh) | 2020-03-31 | 2022-12-06 | 施万生物制药研发Ip有限责任公司 | 经取代的嘧啶和使用方法 |
| CN113461824A (zh) | 2020-03-31 | 2021-10-01 | 普米斯生物技术(珠海)有限公司 | 一种构建多特异性抗体的平台 |
| MY210304A (en) | 2020-04-02 | 2025-09-10 | Mersana Therapeutics Inc | Antibody drug conjugates comprising sting agonists |
| WO2021205444A1 (en) | 2020-04-06 | 2021-10-14 | Yeda Research And Development Co. Ltd. | Methods of diagnosing cancer and predicting responsiveness to therapy |
| EP4134134A4 (en) | 2020-04-10 | 2023-12-27 | ONO Pharmaceutical Co., Ltd. | STING AGONISTIC COMPOUND |
| US20230141284A1 (en) | 2020-04-10 | 2023-05-11 | Ono Pharmaceutical Co., Ltd. | Cancer therapeutic method |
| KR20230009386A (ko) | 2020-04-10 | 2023-01-17 | 주노 쎄러퓨티크스 인코퍼레이티드 | Ｂ-세포 성숙 항원을 표적화하는 키메라 항원 수용체로 조작된 세포 요법 관련 방법 및 용도 |
| CA3171557A1 (en) | 2020-04-14 | 2021-10-21 | Marc S. BALLAS | Combination treatment for cancer involving anti-icos and anti-pd1 antibodies, optionally further involving anti-tim3 antibodies |
| CA3171597A1 (en) | 2020-04-14 | 2021-10-21 | Glaxosmithkline Intellectual Property Development Limited | Combination treatment for cancer |
| PH12022552739A1 (en) | 2020-04-16 | 2024-03-25 | Incyte Corp | Fused tricyclic kras inhibitors |
| WO2021214623A1 (en) | 2020-04-21 | 2021-10-28 | Novartis Ag | Dosing regimen for treating a disease modulated by csf-1r |
| TW202203973A (zh) | 2020-04-22 | 2022-02-01 | 美商默沙東藥廠 | 對介白素-2受體βγc二聚體具偏性且結合至非肽、水溶性聚合物之人類介白素-2結合物 |
| CA3176356A1 (en) | 2020-04-22 | 2021-10-28 | Anne BROOKS | Systems and methods for coordinating manufacturing of cells for patient-specific immunotherapy |
| TW202206100A (zh) | 2020-04-27 | 2022-02-16 | 美商西健公司 | 癌症之治療 |
| US20230181756A1 (en) | 2020-04-30 | 2023-06-15 | Novartis Ag | Ccr7 antibody drug conjugates for treating cancer |
| BR112022021684A2 (pt) | 2020-05-01 | 2023-01-17 | Ngm Biopharmaceuticals Inc | Agente de ligação, anticorpo que liga especificamente ilt2 e ilt4 humanos, agente de ligação ou anticorpo, anticorpo, composição farmacêutica, polinucleotídeo isolado ou polinucleotídeos, vetor ou vetores, célula isolada, método para interromper, inibir ou bloquear a ligação de ilt2 e/ou ilt4, método para interromper, inibir ou bloquear a supressão induzida por ilt2 e/ou ilt4, método para inibir ou diminuir a atividade de células supressoras, método para intensificar ou aumentar a atividade de célula, método para intensificar ou aumentar a atividade de linfócito t citolítico (ctl), método para interromper, inibir ou bloquear a atividade de ilt2 e/ou ilt4, método para interromper, inibir ou bloquear ilt2 ou supressão induzida por ilt4, método para inibir ou diminuir a atividade de mdsc, método para intensificar ou aumentar a atividade de ctl, método para tratar câncer em um sujeito, método para inibir o crescimento tumoral em um sujeito, método para aumentar ou intensificar uma resposta imune, método para inibir o relapso de tumor ou reaparecimento de tumor em um sujeito, método para induzir uma imunidade persistente ou a longo prazo, método para ativar células mieloides, uso do agente de ligação ou anticorpo, composição farmacêutica e combinação |
| WO2021224186A1 (en) | 2020-05-04 | 2021-11-11 | Institut Curie | New pyridine derivatives as radiosensitizers |
| WO2021226206A2 (en) | 2020-05-05 | 2021-11-11 | Teon Therapeutics, Inc. | Cannabinoid receptor type 2 (cb2) modulators and uses thereof |
| EP4146644A1 (en) | 2020-05-06 | 2023-03-15 | Merck Sharp & Dohme LLC | Il4i1 inhibitors and methods of use |
| US11739102B2 (en) | 2020-05-13 | 2023-08-29 | Incyte Corporation | Fused pyrimidine compounds as KRAS inhibitors |
| WO2021231976A1 (en) | 2020-05-14 | 2021-11-18 | Xencor, Inc. | Heterodimeric antibodies that bind prostate specific membrane antigen (psma) and cd3 |
| KR20230012559A (ko) | 2020-05-19 | 2023-01-26 | 베링거 인겔하임 인터내셔날 게엠베하 | 암 치료를 위한 결합 분자 |
| EP4153628A1 (en) | 2020-05-20 | 2023-03-29 | Institut Curie | Single domain antibodies and their use in cancer therapies |
| EP4153301A2 (en) | 2020-05-21 | 2023-03-29 | Board of Regents, The University of Texas System | T cell receptors with vgll1 specificity and uses thereof |
| AU2021280245A1 (en) | 2020-05-26 | 2022-12-08 | Regeneron Pharmaceuticals, Inc. | Methods of treating cervical cancer by administering a PD-1 inhibitor |
| US20230233474A1 (en) | 2020-05-28 | 2023-07-27 | Modernatx, Inc. | Use of mrnas encoding ox40l, il-23 and il-36gamma for treating cancer |
| US20230173095A1 (en) | 2020-05-29 | 2023-06-08 | President And Fellows Of Harvard College | Living cells engineered with polyphenol-functionalized biologically active nanocomplexes |
| WO2021247836A1 (en) | 2020-06-03 | 2021-12-09 | Board Of Regents, The University Of Texas System | Methods for targeting shp-2 to overcome resistance |
| MX2022015261A (es) | 2020-06-03 | 2023-03-14 | Boehringer Ingelheim Int | Rhabdovirus recombinante que codifica una proteina de fusion fc de dominio extracelular cd80. |
| JP2023528071A (ja) | 2020-06-03 | 2023-07-03 | エムヴィ バイオセラピューティクス エスエー | Ａｔｐ加水分解酵素と免疫チェックポイントモジュレーターとの組合せ、並びにその使用 |
| WO2021253041A1 (en) | 2020-06-10 | 2021-12-16 | Theravance Biopharma R&D Ip, Llc | Naphthyridine derivatives useful as alk5 inhibitors |
| EP4165169A1 (en) | 2020-06-11 | 2023-04-19 | Novartis AG | Zbtb32 inhibitors and uses thereof |
| AR122644A1 (es) | 2020-06-19 | 2022-09-28 | Onxeo | Nuevas moléculas de ácido nucleico conjugado y sus usos |
| KR20230027056A (ko) | 2020-06-23 | 2023-02-27 | 노파르티스 아게 | 3-(1-옥소이소인돌린-2-일)피페리딘-2,6-디온 유도체를 포함하는 투약 요법 |
| WO2021260675A1 (en) | 2020-06-24 | 2021-12-30 | Yeda Research And Development Co. Ltd. | Agents for sensitizing solid tumors to treatment |
| WO2021262969A1 (en) | 2020-06-24 | 2021-12-30 | The General Hospital Corporation | Materials and methods of treating cancer |
| WO2021260443A1 (en) | 2020-06-24 | 2021-12-30 | Bayer Aktiengesellschaft | Combinations of 2,3-dihydroimidazo[1,2-c]quinazolines |
| BR112022026090A2 (pt) | 2020-06-25 | 2023-01-17 | Celgene Corp | Métodos para tratar câncer com terapias de combinação |
| CA3183034A1 (en) * | 2020-06-26 | 2021-12-30 | Heyue Zhou | Anti-pd1 antibodies and uses thereof |
| MX2022016548A (es) | 2020-06-26 | 2023-03-14 | Amgen Inc | Muteínas de il-10 y proteínas de fusión de las mismas. |
| EP4172323A1 (en) | 2020-06-29 | 2023-05-03 | Flagship Pioneering Innovations V, Inc. | Viruses engineered to promote thanotransmission and their use in treating cancer |
| KR20230033647A (ko) | 2020-06-30 | 2023-03-08 | 멘두스 비.브이. | 난소암 백신에서 백혈병 유래 세포의 용도 |
| WO2022002874A1 (en) | 2020-06-30 | 2022-01-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the risk of recurrence and/or death of patients suffering from a solid cancer after preoperative adjuvant therapy and radical surgery |
| WO2022002873A1 (en) | 2020-06-30 | 2022-01-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the risk of recurrence and/or death of patients suffering from a solid cancer after preoperative adjuvant therapies |
| AU2021305052A1 (en) | 2020-07-07 | 2023-02-09 | Celgene Corporation | Pharmaceutical compositions comprising (S)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl) benzyl)piperazin-1-yl)-3-fluorobenzonitrile and methods of using the same |
| WO2022008519A1 (en) | 2020-07-07 | 2022-01-13 | BioNTech SE | Therapeutic rna for hpv-positive cancer |
| EP4178680A4 (en) | 2020-07-10 | 2024-07-31 | Precigen, Inc. | FUSION CONSTRUCTS AND THEIR METHODS OF USE |
| US20230257365A1 (en) | 2020-07-10 | 2023-08-17 | The Regents Of The University Of Michigan | Small molecule androgen receptor protein degraders |
| WO2022009157A1 (en) | 2020-07-10 | 2022-01-13 | Novartis Ag | Lhc165 and spartalizumab combinations for treating solid tumors |
| WO2022011205A1 (en) | 2020-07-10 | 2022-01-13 | The Regents Of The University Of Michigan | Androgen receptor protein degraders |
| JP2023535610A (ja) | 2020-07-28 | 2023-08-18 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | ガンを予防及び処置するための方法及び組成物 |
| US20230271940A1 (en) | 2020-08-03 | 2023-08-31 | Novartis Ag | Heteroaryl substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
| WO2022036079A1 (en) | 2020-08-13 | 2022-02-17 | Bristol-Myers Squibb Company | Methods of redirecting of il-2 to target cells of interest |
| EP4204458A4 (en) | 2020-08-26 | 2024-10-09 | Marengo Therapeutics, Inc. | METHODS FOR DETECTION OF TRBC1 OR TRBC2 |
| MA71214A (fr) | 2020-08-26 | 2025-04-30 | Regeneron Pharmaceuticals, Inc. | Méthodes de traitement du cancer par administration d'un inhibiteur de pd-1 |
| WO2022047093A1 (en) | 2020-08-28 | 2022-03-03 | Incyte Corporation | Vinyl imidazole compounds as inhibitors of kras |
| WO2022047189A1 (en) | 2020-08-28 | 2022-03-03 | Bristol-Myers Squibb Company | Lag-3 antagonist therapy for hepatocellular carcinoma |
| US20230331848A1 (en) * | 2020-08-31 | 2023-10-19 | Biosion Inc. | Pd-1 binding antibodies and uses thereof |
| WO2022043558A1 (en) | 2020-08-31 | 2022-03-03 | Advanced Accelerator Applications International Sa | Method of treating psma-expressing cancers |
| EP4204021A1 (en) | 2020-08-31 | 2023-07-05 | Advanced Accelerator Applications International S.A. | Method of treating psma-expressing cancers |
| MX2023002326A (es) | 2020-08-31 | 2023-03-21 | Bristol Myers Squibb Co | Firma de localizacion celular e inmunoterapia. |
| KR20230087451A (ko) | 2020-09-02 | 2023-06-16 | 주식회사 파멥신 | 암 환자를 치료하기 위한 pd-1 길항제 및 vegfr-2에 대한 길항제의 조합 요법 |
| US11932692B2 (en) | 2020-09-03 | 2024-03-19 | Regeneron Pharmaceuticals, Inc. | Methods of treating cancer pain by administering a PD-1 inhibitor |
| CR20230155A (es) | 2020-09-14 | 2023-06-27 | Boehringer Ingelheim Int | Vacuna heteróloga de estímulo primario |
| AU2021347967A1 (en) | 2020-09-24 | 2023-06-01 | Merck Sharp & Dohme Llc | Stable formulations of programmed death receptor 1 (pd-1) antibodies and hyaluronidase variants and fragments thereof and methods of use thereof |
| US11767320B2 (en) | 2020-10-02 | 2023-09-26 | Incyte Corporation | Bicyclic dione compounds as inhibitors of KRAS |
| US20230374160A1 (en) | 2020-10-02 | 2023-11-23 | Regeneron Pharmaceuticals, Inc. | Combination of antibodies for treating cancer with reduced cytokine release syndrome |
| WO2022072820A1 (en) | 2020-10-02 | 2022-04-07 | Dracen Pharmaceuticals, Inc. | Lyophilized composition comprising (s)-isopropyl 2-((s)-2- acetamido-3-(1h-indol-3-yl)propanamido)-6-diazo-5- oxohexanoate for subcutaneous administration and the use thereof |
| JP2023544410A (ja) | 2020-10-05 | 2023-10-23 | ブリストル－マイヤーズ スクイブ カンパニー | タンパク質を濃縮するための方法 |
| EP4225374A1 (en) | 2020-10-08 | 2023-08-16 | TargImmune Therapeutics AG | Immunotherapy for the treatment of cancer |
| WO2022079270A1 (en) | 2020-10-16 | 2022-04-21 | Université D'aix-Marseille | Anti-gpc4 single domain antibodies |
| CA3196243A1 (en) | 2020-10-20 | 2022-04-28 | Angela Marinetti | Metallic trans-(n-heterocyclic carbene)-amine-platinum complexes and uses thereof for treating cancer |
| WO2022084531A1 (en) | 2020-10-23 | 2022-04-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treating glioma |
| MX2023004493A (es) | 2020-10-23 | 2023-05-10 | Bristol Myers Squibb Co | Terapia de agonista del gen-3 de activacion del linfocito (lag-3) para cancer de pulmon. |
| JPWO2022092085A1 (enExample) | 2020-10-28 | 2022-05-05 | ||
| IL302346A (en) | 2020-10-28 | 2023-06-01 | Ikena Oncology Inc | Combination of an ahr inhibitor with a pdx inhibitor or doxorubicine |
| US20220133902A1 (en) * | 2020-11-04 | 2022-05-05 | Heidelberg Pharma Research Gmbh | Composition Comprising a Combination of Immune Checkpoint Inhibitor and Antibody-Amatoxin Conjugate for Use in Cancer Therapy |
| MX2023005192A (es) | 2020-11-04 | 2023-05-15 | Heidelberg Pharma Res Gmbh | Composicion que comprende una combinacion de inhibidor de punto de control inmunitario y conjugado de anticuerpo-amatoxina para uso en la terapia del cancer. |
| WO2022098845A1 (en) | 2020-11-05 | 2022-05-12 | Board Of Regents, The University Of Texas System | Engineered t cell receptors targeting egfr antigens and methods of use |
| CR20230230A (es) | 2020-11-06 | 2023-07-27 | Incyte Corp | Proceso para hacer un inhibidor de pd-1/pdl1 y sales y formas cristalinas del mismo |
| AU2021373366A1 (en) | 2020-11-06 | 2023-06-01 | Novartis Ag | Cd19 binding molecules and uses thereof |
| US11760756B2 (en) | 2020-11-06 | 2023-09-19 | Incyte Corporation | Crystalline form of a PD-1/PD-L1 inhibitor |
| WO2022099018A1 (en) | 2020-11-06 | 2022-05-12 | Incyte Corporation | Process of preparing a pd-1/pd-l1 inhibitor |
| MX2023004941A (es) | 2020-11-08 | 2023-07-12 | Seagen Inc | Conjugado de anticuerpo y fármaco para terapia de combinación con inhibidor de células inmunitarias. |
| WO2022104109A1 (en) | 2020-11-13 | 2022-05-19 | Catamaran Bio, Inc. | Genetically modified natural killer cells and methods of use thereof |
| US20230390303A1 (en) | 2020-11-13 | 2023-12-07 | Ono Pharmaceutical Co., Ltd. | Cancer treatment by combination of ep4 antagonist and immune checkpoint inhibitor |
| EP4244392A1 (en) | 2020-11-16 | 2023-09-20 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and compositions for predicting and treating uveal melanoma |
| US20230416830A1 (en) | 2020-11-16 | 2023-12-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for predicting and treating uveal melanoma |
| CN117580859A (zh) | 2020-11-17 | 2024-02-20 | 思进股份有限公司 | 用图卡替尼和抗pd-1/抗pd-l1抗体的组合治疗癌症的方法 |
| WO2022106505A1 (en) | 2020-11-18 | 2022-05-27 | Institut Curie | Dimers of biguanidines and their therapeutic uses |
| AU2021388155A1 (en) | 2020-11-25 | 2023-06-15 | Catamaran Bio, Inc. | Cellular therapeutics engineered with signal modulators and methods of use thereof |
| TWI877433B (zh) | 2020-11-30 | 2025-03-21 | 大陸商杭州阿諾生物醫藥科技有限公司 | 用於治療ｐｉｋ３ｃａ突變癌症的組合療法 |
| US20220168293A1 (en) | 2020-12-02 | 2022-06-02 | Pfizer Inc. | Time to resolution of axitinib-related adverse events |
| WO2022120179A1 (en) | 2020-12-03 | 2022-06-09 | Bristol-Myers Squibb Company | Multi-tumor gene signatures and uses thereof |
| PH12023500013A1 (en) | 2020-12-04 | 2024-03-11 | Tidal Therapeutics Inc | Ionizable cationic lipids and lipi nanoparticles, and methods of synthesis and use thereof |
| CA3204091A1 (en) | 2020-12-08 | 2022-06-16 | Infinity Pharmaceuticals, Inc. | Eganelisib for use in the treatment of pd-l1 negative cancer |
| TW202237119A (zh) | 2020-12-10 | 2022-10-01 | 美商住友製藥腫瘤公司 | Ａｌｋ﹘５抑制劑和彼之用途 |
| WO2022130206A1 (en) | 2020-12-16 | 2022-06-23 | Pfizer Inc. | TGFβr1 INHIBITOR COMBINATION THERAPIES |
| ES2967381T3 (es) | 2020-12-18 | 2024-04-30 | Lamkap Bio Beta Ag | Anticuerpos biespecíficos contra CEACAM5 y CD47 |
| WO2022135667A1 (en) | 2020-12-21 | 2022-06-30 | BioNTech SE | Therapeutic rna for treating cancer |
| TW202245808A (zh) | 2020-12-21 | 2022-12-01 | 德商拜恩迪克公司 | 用於治療癌症之治療性ｒｎａ |
| WO2022135666A1 (en) | 2020-12-21 | 2022-06-30 | BioNTech SE | Treatment schedule for cytokine proteins |
| MX2023007650A (es) | 2020-12-28 | 2023-09-11 | Bristol Myers Squibb Co | Metodos de tratamiento de tumores. |
| DK4267105T3 (da) | 2020-12-28 | 2025-05-19 | Bristol Myers Squibb Co | Antistofsammensætninger og fremgangsmåder til anvendelse deraf |
| US20220233529A1 (en) | 2020-12-29 | 2022-07-28 | Incyte Corporation | Combination therapy comprising a2a/a2b inhibitors, pd-1/pd-l1 inhibitors, and anti-cd73 antibodies |
| CN116745322A (zh) | 2021-01-08 | 2023-09-12 | 百时美施贵宝公司 | 使用抗岩藻糖基-gm1抗体的组合疗法 |
| CN117916271A (zh) | 2021-01-14 | 2024-04-19 | 居里研究所 | Her2单域抗体变体及其car |
| CA3205538A1 (en) | 2021-01-19 | 2022-07-28 | Han XIAO | Bone-specific delivery of polypeptides |
| CN116963773A (zh) | 2021-01-21 | 2023-10-27 | 浙江养生堂天然药物研究所有限公司 | 治疗肿瘤的组合物及方法 |
| CA3203705A1 (en) | 2021-01-22 | 2022-07-28 | Erik Hans MANTING | Methods of tumor vaccination |
| KR20230150295A (ko) | 2021-01-29 | 2023-10-30 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 키나제 억제제를 이용한 암의 치료 방법 |
| EP4284510A1 (en) | 2021-01-29 | 2023-12-06 | Novartis AG | Dosage regimes for anti-cd73 and anti-entpd2 antibodies and uses thereof |
| CN116761889A (zh) * | 2021-01-29 | 2023-09-15 | 明慧医药（杭州）有限公司 | 抗原结合蛋白及其用途 |
| US12110330B2 (en) * | 2021-01-29 | 2024-10-08 | Merck Sharp & Dohme Llc | Compositions of programmed death receptor 1 (PD-1) antibodies and methods of obtaining the compositions thereof |
| CN115105600B (zh) | 2021-02-10 | 2024-07-19 | 同润生物医药(上海)有限公司 | 一种PI3Kδ/γ的药物组合及其治疗肿瘤的方法 |
| WO2022174102A1 (en) | 2021-02-12 | 2022-08-18 | Synthorx, Inc. | Lung cancer combination therapy with il-2 conjugates and an anti-pd-1 antibody or antigen-binding fragment thereof |
| CN116917273A (zh) | 2021-03-02 | 2023-10-20 | 葛兰素史克知识产权发展有限公司 | 作为dnmt1抑制剂的经取代的吡啶 |
| WO2022187423A1 (en) | 2021-03-03 | 2022-09-09 | The Regents Of The University Of Michigan | Cereblon ligands |
| WO2022187419A1 (en) | 2021-03-03 | 2022-09-09 | The Regents Of The University Of Michigan | Small molecule degraders of androgen receptor |
| WO2022184937A1 (en) | 2021-03-05 | 2022-09-09 | Leadartis, S.L. | Trimeric polypeptides and uses thereof in the treatment of cancer |
| EP4305067A1 (en) | 2021-03-09 | 2024-01-17 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and cldn6 |
| KR20230157388A (ko) | 2021-03-12 | 2023-11-16 | 멘두스 비.브이. | 백신접종의 방법 및 cd47 차단의 용도 |
| WO2022189618A1 (en) | 2021-03-12 | 2022-09-15 | Institut Curie | Nitrogen-containing heterocycles as radiosensitizers |
| EP4308118A1 (en) | 2021-03-17 | 2024-01-24 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods and compositions for treating melanoma |
| WO2022195551A1 (en) | 2021-03-18 | 2022-09-22 | Novartis Ag | Biomarkers for cancer and methods of use thereof |
| JP2024512478A (ja) | 2021-03-19 | 2024-03-19 | ハイデルベルク ファルマ リサーチ ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｂリンパ球特異的アマトキシン抗体コンジュゲート |
| WO2022198101A1 (en) | 2021-03-19 | 2022-09-22 | Trained Therapeutix Discovery, Inc. | Compounds for regulating trained immunity, and their methods of use |
| US20250326846A1 (en) | 2021-03-23 | 2025-10-23 | Regeneron Pharmaceuticals, Inc. | Methods of treating cancer in immunosuppressed or immunocompromised patients by administering a pd-1 inhibitor |
| JP2024511166A (ja) | 2021-03-25 | 2024-03-12 | オンクセルナ セラピューティクス，インコーポレイテッド | 癌の標的療法 |
| TW202304506A (zh) | 2021-03-25 | 2023-02-01 | 日商安斯泰來製藥公司 | 涉及抗claudin 18.2抗體的組合治療以治療癌症 |
| JP2024514245A (ja) | 2021-03-29 | 2024-03-29 | ジュノー セラピューティクス インコーポレイテッド | チェックポイント阻害剤療法とｃａｒ ｔ細胞療法との組合せを用いた投薬および処置のための方法 |
| JP2024511831A (ja) | 2021-03-31 | 2024-03-15 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド | 抗原結合タンパク質およびそれらの組み合わせ |
| US20220325287A1 (en) | 2021-03-31 | 2022-10-13 | Flagship Pioneering Innovations V, Inc. | Thanotransmission polypeptides and their use in treating cancer |
| WO2022212876A1 (en) | 2021-04-02 | 2022-10-06 | The Regents Of The University Of California | Antibodies against cleaved cdcp1 and uses thereof |
| TW202304979A (zh) | 2021-04-07 | 2023-02-01 | 瑞士商諾華公司 | 抗ＴＧＦβ抗體及其他治療劑用於治療增殖性疾病之用途 |
| JP2024514836A (ja) | 2021-04-08 | 2024-04-03 | ニューリックス セラピューティクス，インコーポレイテッド | Ｃｂｌ－ｂ阻害化合物との組み合わせ療法 |
| TW202305009A (zh) | 2021-04-08 | 2023-02-01 | 美商默沙東有限責任公司 | 以皮下投予抗pd1抗體治療癌症之方法 |
| KR20240004462A (ko) | 2021-04-08 | 2024-01-11 | 마렝고 테라퓨틱스, 인크. | Tcr에 결합하는 다기능성 분자 및 이의 용도 |
| WO2022216979A1 (en) | 2021-04-08 | 2022-10-13 | Board Of Regents, The University Of Texas System | Compounds and methods for theranostic targeting of parp activity |
| CA3216170A1 (en) | 2021-04-09 | 2022-10-13 | Seagen Inc. | Methods of treating cancer with anti-tigit antibodies |
| EP4323405A1 (en) | 2021-04-12 | 2024-02-21 | Incyte Corporation | Combination therapy comprising an fgfr inhibitor and a nectin-4 targeting agent |
| CA3213079A1 (en) | 2021-04-13 | 2022-10-20 | Kristin Lynne ANDREWS | Amino-substituted heterocycles for treating cancers with egfr mutations |
| AU2022258829A1 (en) | 2021-04-16 | 2023-10-26 | Novartis Ag | Antibody drug conjugates and methods for making thereof |
| JP2024514673A (ja) | 2021-04-20 | 2024-04-02 | シージェン インコーポレイテッド | 抗体依存性細胞傷害の調節 |
| US20240158861A1 (en) | 2021-04-23 | 2024-05-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treating cell senescence accumulation related disease |
| BR112023022439A2 (pt) | 2021-04-26 | 2023-12-26 | Celanese Eva Performance Polymers Llc | Dispositivo implantável para liberação sustentada de um composto de fármaco macromolecular |
| JP2024518302A (ja) | 2021-04-29 | 2024-05-01 | イェダ リサーチ アンド デベロップメント カンパニー リミテッド | Ｒａｓ誘導性再発性ネオアンチゲンに対するｔ細胞受容体およびそれらを同定するための方法 |
| WO2022227015A1 (en) | 2021-04-30 | 2022-11-03 | Merck Sharp & Dohme Corp. | Il4i1 inhibitors and methods of use |
| AU2022270170A1 (en) | 2021-05-07 | 2023-09-21 | Surface Oncology, LLC | Anti-il-27 antibodies and uses thereof |
| WO2022238386A1 (en) | 2021-05-10 | 2022-11-17 | Institut Curie | Methods for the treatment of cancer, inflammatory diseases and autoimmune diseases |
| AR125874A1 (es) | 2021-05-18 | 2023-08-23 | Novartis Ag | Terapias de combinación |
| CN117396222A (zh) | 2021-05-21 | 2024-01-12 | 天津立博美华基因科技有限责任公司 | 药物组合及其用途 |
| US20240239907A1 (en) | 2021-05-25 | 2024-07-18 | Edelweiss Immune Inc | C-X-C Motif Chemokine Receptor 6 (CXCR6) Binding Molecules, and Methods of Using the Same |
| WO2022251359A1 (en) | 2021-05-26 | 2022-12-01 | Theravance Biopharma R&D Ip, Llc | Bicyclic inhibitors of alk5 and methods of use |
| KR20240014054A (ko) | 2021-05-26 | 2024-01-31 | 센트로 데 인뮤놀러지아 모레큘러 | 상피 유래 종양을 가진 환자를 치료하기 위한 치료용 조성물의 용도 |
| TW202307210A (zh) | 2021-06-01 | 2023-02-16 | 瑞士商諾華公司 | Ｃｄ１９和ｃｄ２２嵌合抗原受體及其用途 |
| WO2022256538A1 (en) | 2021-06-03 | 2022-12-08 | Synthorx, Inc. | Head and neck cancer combination therapy comprising an il-2 conjugate and cetuximab |
| GB202107994D0 (en) | 2021-06-04 | 2021-07-21 | Kymab Ltd | Treatment of cancer |
| CA3218590A1 (en) | 2021-06-07 | 2022-12-15 | Providence Health & Services - Oregon | Cxcr5, pd-1, and icos expressing tumor reactive cd4 t cells and their use |
| EP4352059A1 (en) | 2021-06-09 | 2024-04-17 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| JP2024522188A (ja) | 2021-06-09 | 2024-06-11 | インサイト・コーポレイション | Ｆｇｆｒ阻害剤としての三環式ヘテロ環 |
| JP7556468B2 (ja) | 2021-06-10 | 2024-09-26 | 小野薬品工業株式会社 | Ｃｄ４７阻害物質、免疫チェックポイント阻害物質および標準療法の併用によるがん治療法 |
| TW202317623A (zh) | 2021-06-14 | 2023-05-01 | 美商再生元醫藥公司 | 基於il2之治療劑及其使用方法 |
| WO2022263632A1 (en) | 2021-06-18 | 2022-12-22 | Alligator Bioscience Ab | Novel combination therapies and uses thereof |
| US11981671B2 (en) | 2021-06-21 | 2024-05-14 | Incyte Corporation | Bicyclic pyrazolyl amines as CDK2 inhibitors |
| EP4363059A1 (en) | 2021-06-29 | 2024-05-08 | Flagship Pioneering Innovations V, Inc. | Immune cells engineered to promote thanotransmission and uses thereof |
| JP2024527322A (ja) | 2021-07-02 | 2024-07-24 | イエール ユニバーシティ | がんを治療するための組成物および方法 |
| CA3224674A1 (en) | 2021-07-07 | 2023-01-12 | Pei Gan | Tricyclic compounds as inhibitors of kras |
| JP2024525758A (ja) | 2021-07-13 | 2024-07-12 | ビオンテック・ソシエタス・エウロパエア | がんのための併用療法におけるｃｄ４０およびｃｄ１３７に対する多重特異性結合剤 |
| US20230114765A1 (en) | 2021-07-14 | 2023-04-13 | Incyte Corporation | Tricyclic compounds as inhibitors of kras |
| JP2024526840A (ja) | 2021-07-19 | 2024-07-19 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | がんを処置するためのチェックポイント阻害剤と腫瘍溶解性ウイルスの組合せ |
| JP2024529502A (ja) | 2021-07-30 | 2024-08-06 | オーエヌエー セラピューティクス エセ．エレ． | 抗ｃｄ３６抗体及び癌を治療するためのそれらの使用 |
| US20250009877A1 (en) | 2021-07-30 | 2025-01-09 | Seagen Inc. | Treatment for cancer |
| CN117794953A (zh) | 2021-08-03 | 2024-03-29 | 豪夫迈·罗氏有限公司 | 双特异性抗体及使用方法 |
| AU2022324040A1 (en) | 2021-08-04 | 2024-02-22 | The Regents Of The University Of Colorado, A Body Corporate | Lat activating chimeric antigen receptor t cells and methods of use thereof |
| US20250135232A1 (en) | 2021-08-05 | 2025-05-01 | Institut Curie | Scanning dynamic device for minibeams production |
| IL310662A (en) | 2021-08-23 | 2024-04-01 | Immunitas Therapeutics Inc | Anti-CD161 antibodies and their uses |
| EP4396187A1 (en) | 2021-08-31 | 2024-07-10 | Incyte Corporation | Naphthyridine compounds as inhibitors of kras |
| JP2024532621A (ja) | 2021-08-31 | 2024-09-05 | イエール ユニバーシティ | がんを治療するための組成物および方法 |
| CA3230117A1 (en) | 2021-09-02 | 2023-03-09 | Mark Trautwein | Anti-cecam6 antibodies with reduced side-effects |
| WO2023034530A1 (en) | 2021-09-02 | 2023-03-09 | Teon Therapeutics, Inc. | Methods of improving growth and function of immune cells |
| CA3231180A1 (en) | 2021-09-08 | 2023-03-16 | Redona Therapeutics, Inc. | Papd5 and/or papd7 inhibiting 4-oxo-1,4-dihydroquinoline-3-carboxylic acid derivatives |
| WO2023041744A1 (en) | 2021-09-17 | 2023-03-23 | Institut Curie | Bet inhibitors for treating pab1 deficient cancer |
| WO2023049697A1 (en) | 2021-09-21 | 2023-03-30 | Incyte Corporation | Hetero-tricyclic compounds as inhibitors of kras |
| WO2023051926A1 (en) | 2021-09-30 | 2023-04-06 | BioNTech SE | Treatment involving non-immunogenic rna for antigen vaccination and pd-1 axis binding antagonists |
| WO2023056421A1 (en) | 2021-10-01 | 2023-04-06 | Incyte Corporation | Pyrazoloquinoline kras inhibitors |
| CN118369419A (zh) | 2021-10-05 | 2024-07-19 | 赛托维亚治疗有限责任公司 | 自然杀伤细胞及其使用方法 |
| TW202327595A (zh) | 2021-10-05 | 2023-07-16 | 美商輝瑞大藥廠 | 用於治療癌症之氮雜內醯胺化合物的組合 |
| EP4413040A1 (en) | 2021-10-06 | 2024-08-14 | Genmab A/S | Multispecific binding agents against pd-l1 and cd137 in combination |
| TW202333802A (zh) | 2021-10-11 | 2023-09-01 | 德商拜恩迪克公司 | 用於肺癌之治療性rna(二) |
| EP4429706A1 (en) * | 2021-10-14 | 2024-09-18 | F. Hoffmann-La Roche AG | Alternative pd1-il7v immunoconjugates for the treatment of cancer |
| CR20240197A (es) | 2021-10-14 | 2024-08-07 | Incyte Corp | Compuestos de quinolina como inhibidores de kras |
| KR20240099161A (ko) | 2021-10-20 | 2024-06-28 | 다케다 야쿠힌 고교 가부시키가이샤 | Bcma를 표적화하는 조성물 및 이의 사용 방법 |
| CN118159568A (zh) | 2021-10-21 | 2024-06-07 | 杭州阿诺生物医药科技有限公司 | 一种融合多肽及其用途 |
| WO2023076880A1 (en) | 2021-10-25 | 2023-05-04 | Board Of Regents, The University Of Texas System | Foxo1-targeted therapy for the treatment of cancer |
| WO2023077034A1 (en) | 2021-10-28 | 2023-05-04 | Lyell Immunopharma, Inc. | Methods for culturing immune cells |
| AU2022377628A1 (en) | 2021-10-29 | 2024-04-11 | Seagen Inc. | Methods of treating cancer with a combination of an anti-pd-1 antibody and an anti-cd30 antibody-drug conjugate |
| US20240417473A1 (en) | 2021-10-29 | 2024-12-19 | Bristol-Myers Squibb Company | Lag-3 antagonist therapy for hematological cancer |
| WO2023081730A1 (en) | 2021-11-03 | 2023-05-11 | Teon Therapeutics, Inc. | 4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide derivatives as cannabinoid cb2 receptor modulators for the treatment of cancer |
| WO2023078900A1 (en) | 2021-11-03 | 2023-05-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treating triple negative breast cancer (tnbc) |
| WO2023079428A1 (en) | 2021-11-03 | 2023-05-11 | Pfizer Inc. | Combination therapies using tlr7/8 agonist |
| WO2023083439A1 (en) | 2021-11-09 | 2023-05-19 | BioNTech SE | Tlr7 agonist and combinations for cancer treatment |
| MX2024005722A (es) | 2021-11-12 | 2024-05-28 | Novartis Ag | Terapia de combinacion para el tratamiento del cancer de pulmon. |
| JP2024539432A (ja) | 2021-11-15 | 2024-10-28 | 中国科学院生物物理研究所 | インターロイキン１５を有効成分とする融合タンパク質構築物およびその使用 |
| US20250019708A1 (en) | 2021-11-19 | 2025-01-16 | Institut Curie | Methods for the treatment of hrd cancer and brca-associated cancer |
| MX2024006113A (es) | 2021-11-22 | 2024-07-29 | Incyte Corp | Terapia de combinación que comprende un inhibidor del receptor del factor de crecimiento de fibroblastos (fgfr) y un inhibidor del sarcoma de rata de kirsten (kras). |
| WO2023097211A1 (en) | 2021-11-24 | 2023-06-01 | The University Of Southern California | Methods for enhancing immune checkpoint inhibitor therapy |
| TW202329937A (zh) | 2021-12-03 | 2023-08-01 | 美商英塞特公司 | 雙環胺ｃｋ１２抑制劑 |
| WO2023099763A1 (en) | 2021-12-03 | 2023-06-08 | Institut Curie | Sirt6 inhibitors for use in treating resistant hrd cancer |
| WO2023104910A1 (en) | 2021-12-08 | 2023-06-15 | Tessa Therapeutics Ltd. | Treatment of lymphoma |
| WO2023107705A1 (en) | 2021-12-10 | 2023-06-15 | Incyte Corporation | Bicyclic amines as cdk12 inhibitors |
| US11976073B2 (en) | 2021-12-10 | 2024-05-07 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
| IL313439A (en) | 2021-12-16 | 2024-08-01 | Valerio Therapeutics | New conjugated nucleic acid molecules and their uses |
| EP4452327A1 (en) | 2021-12-20 | 2024-10-30 | Synthorx, Inc. | Head and neck cancer combination therapy comprising an il-2 conjugate and pembrolizumab |
| WO2023118165A1 (en) | 2021-12-21 | 2023-06-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treating melanoma |
| CR20240297A (es) | 2021-12-22 | 2024-09-18 | Incyte Corp | Sales y formas sólidas de un inhibidor de fgfr y procesos para su preparación |
| CN119836296A (zh) | 2021-12-30 | 2025-04-15 | 新免疫技术有限公司 | 用il-7蛋白和vegf拮抗剂的组合治疗肿瘤的方法 |
| AU2023204751A1 (en) | 2022-01-07 | 2024-07-11 | Regeneron Pharmaceuticals, Inc. | Methods of treating recurrent ovarian cancer with bispecific anti-muc16 x anti-cd3 antibodies alone or in combination with anti-pd-1 antibodies |
| MX2024008831A (es) | 2022-01-26 | 2024-07-25 | Bristol Myers Squibb Co | Terapia combinada para carcinoma hepatocelular. |
| WO2023154799A1 (en) | 2022-02-14 | 2023-08-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Combination immunotherapy for treating cancer |
| TW202523314A (zh) | 2022-02-14 | 2025-06-16 | 美商基利科學股份有限公司 | 抗病毒吡唑并吡啶酮化合物 |
| US20250152643A1 (en) | 2022-02-17 | 2025-05-15 | Regeneron Pharmaceuticals, Inc. | Combinations of checkpoint inhibitors and oncolytic virus for treating cancer |
| US20230277669A1 (en) | 2022-02-24 | 2023-09-07 | Amazentis Sa | Uses of urolithins |
| CN118765284A (zh) | 2022-02-25 | 2024-10-11 | 百时美施贵宝公司 | 结直肠癌的组合疗法 |
| WO2023168404A1 (en) | 2022-03-04 | 2023-09-07 | Bristol-Myers Squibb Company | Methods of treating a tumor |
| AU2023229902A1 (en) | 2022-03-07 | 2024-08-29 | Mabxience Research, S.L. | Stable formulations for antibodies |
| PE20250667A1 (es) | 2022-03-07 | 2025-03-04 | Incyte Corp | Formas solidas, sales y procesos de preparacion de un inhibidor de cdk2 |
| US20250179170A1 (en) | 2022-03-08 | 2025-06-05 | Alentis Therapeutics Ag | Use of anti-claudin-1 antibodies to increase t cell availability |
| CN118871127A (zh) | 2022-03-10 | 2024-10-29 | 格纳西尼有限公司 | 用于治疗头颈癌的三重组合药物给药疗法 |
| WO2023176881A1 (ja) | 2022-03-16 | 2023-09-21 | 第一三共株式会社 | 多重特異的分子と免疫チェックポイント阻害剤の組み合わせ |
| IL315405A (en) | 2022-03-17 | 2024-11-01 | Regeneron Pharma | Methods for treating recurrent epithelioid sarcoma using bispecific anti-MUC16 and anti-CD3 antibodies alone or in combination with anti-PD-1 antibodies |
| JP2025509749A (ja) | 2022-03-18 | 2025-04-11 | ブリストル－マイヤーズ スクイブ カンパニー | ポリペプチドの単離方法 |
| EP4499134A1 (en) | 2022-03-24 | 2025-02-05 | Institut Curie | Immunotherapy targeting tumor transposable element derived neoantigenic peptides in glioblastoma |
| EP4499677A1 (en) | 2022-03-31 | 2025-02-05 | Institut Curie | Modified rela protein for inducing interferon expression and engineered immune cells with improved interferon expression |
| WO2023192478A1 (en) | 2022-04-01 | 2023-10-05 | Bristol-Myers Squibb Company | Combination therapy with anti-il-8 antibodies and anti-pd-1 antibodies for treating cancer |
| WO2023196988A1 (en) | 2022-04-07 | 2023-10-12 | Modernatx, Inc. | Methods of use of mrnas encoding il-12 |
| WO2023196987A1 (en) | 2022-04-07 | 2023-10-12 | Bristol-Myers Squibb Company | Methods of treating tumor |
| WO2023194608A1 (en) | 2022-04-07 | 2023-10-12 | Institut Curie | Myeloid cells modified by chimeric antigen receptor and uses thereof for anti-cancer therapy |
| EP4504244A1 (en) | 2022-04-07 | 2025-02-12 | Institut Curie | Myeloid cells modified by chimeric antigen receptor with cd40 and uses thereof for anti-cancer therapy |
| US20230326022A1 (en) | 2022-04-08 | 2023-10-12 | Bristol-Myers Squibb Company | Machine Learning Identification, Classification, and Quantification of Tertiary Lymphoid Structures |
| EP4507704A1 (en) | 2022-04-15 | 2025-02-19 | Iovance Biotherapeutics, Inc. | Til expansion processes using specific cytokine combinations and/or akti treatment |
| EP4514382A1 (en) | 2022-04-28 | 2025-03-05 | Musc Foundation for Research Development | Chimeric antigen receptor modified regulatory t cells for treating cancer |
| WO2023213763A1 (en) | 2022-05-02 | 2023-11-09 | Transgene | Poxvirus encoding a binding agent comprising an anti- pd-l1 sdab |
| WO2023213764A1 (en) | 2022-05-02 | 2023-11-09 | Transgene | Fusion polypeptide comprising an anti-pd-l1 sdab and a member of the tnfsf |
| WO2023214325A1 (en) | 2022-05-05 | 2023-11-09 | Novartis Ag | Pyrazolopyrimidine derivatives and uses thereof as tet2 inhibitors |
| CN119451985A (zh) | 2022-05-12 | 2025-02-14 | 健玛保 | 在组合疗法中能够结合cd27的结合剂 |
| IL316751A (en) | 2022-05-16 | 2025-01-01 | Regeneron Pharma | Methods for treating metastatic castration-resistant prostate cancer using bispecific antibodies against PSMA and anti-CD3 alone or in combination with anti-PD-1 antibodies |
| EP4531927A1 (en) | 2022-05-24 | 2025-04-09 | Daiichi Sankyo Company, Limited | Dosage regimen of an anti-cdh6 antibody-drug conjugate |
| WO2023230554A1 (en) | 2022-05-25 | 2023-11-30 | Pfizer Inc. | Combination of a braf inhibitor, an egfr inhibitor, and a pd-1 antagonist for the treatment of braf v600e-mutant, msi-h/dmmr colorectal cancer |
| US20240026001A1 (en) | 2022-05-25 | 2024-01-25 | Surface Oncology, Inc. | Use of anti-il-27 antibodies |
| CA3257502A1 (en) | 2022-05-27 | 2023-11-30 | Takeda Pharmaceutical Company Limited | CD38 BINDING FUSION PROTEIN ASSAY |
| AR129423A1 (es) | 2022-05-27 | 2024-08-21 | Viiv Healthcare Co | Compuestos útiles en la terapia contra el hiv |
| CA3258064A1 (en) | 2022-06-02 | 2023-12-07 | Bristol-Myers Squibb Company | ANTIBODY COMPOSITIONS AND THEIR METHODS OF USE |
| TW202412744A (zh) | 2022-06-07 | 2024-04-01 | 瑞士商意梭凱普公司 | 包括應用在食道黏膜之藥劑的藥物遞送系統及其應用 |
| US20240002331A1 (en) | 2022-06-08 | 2024-01-04 | Tidal Therapeutics, Inc. | Ionizable cationic lipids and lipid nanoparticles, and methods of synthesis and use thereof |
| EP4536362A1 (en) | 2022-06-08 | 2025-04-16 | Incyte Corporation | Tricyclic triazolo compounds as dgk inhibitors |
| CA3248576A1 (en) | 2022-06-16 | 2023-12-21 | Lamkap Bio Beta Ltd | POLYTHERAPY OF BISPECIFIC ANTIBODY AGAINST CEACAM5 AND CD47, AND BISPECIFIC ANTIBODY AGAINST CEACAM5 AND CD3 |
| KR20250039519A (ko) | 2022-06-16 | 2025-03-20 | 세파론 엘엘씨 | 항-pd-1 항체-약화된 il-2 면역접합체 및 그의 용도 |
| WO2023250430A1 (en) | 2022-06-22 | 2023-12-28 | Incyte Corporation | Bicyclic amine cdk12 inhibitors |
| WO2023250400A1 (en) | 2022-06-22 | 2023-12-28 | Juno Therapeutics, Inc. | Treatment methods for second line therapy of cd19-targeted car t cells |
| GB202209518D0 (en) | 2022-06-29 | 2022-08-10 | Snipr Biome Aps | Treating & preventing E coli infections |
| JP2025523573A (ja) | 2022-07-01 | 2025-07-23 | トランジェーヌ | サーファクタントタンパク質－ｄとｔｎｆｓｆのメンバーを含んでなる融合タンパク質 |
| KR20250039392A (ko) | 2022-07-11 | 2025-03-20 | 오토노머스 테라퓨틱스, 인코포레이티드 | 암호화된 rna 및 이의 사용 방법 |
| WO2024015731A1 (en) | 2022-07-11 | 2024-01-18 | Incyte Corporation | Fused tricyclic compounds as inhibitors of kras g12v mutants |
| WO2024015372A1 (en) | 2022-07-14 | 2024-01-18 | Teon Therapeutics, Inc. | Adenosine receptor antagonists and uses thereof |
| EP4310197A1 (en) | 2022-07-21 | 2024-01-24 | Fundación para la Investigación Biomédica del Hospital Universitario Puerta de Hierro Majadahonda | Method for identifying lung cancer patients for a combination treatment of immuno- and chemotherapy |
| EP4561624A1 (en) * | 2022-07-25 | 2025-06-04 | Agensys, Inc. | Methods for treating patients with locally advanced or metastatic urothelial cancer with antibody drug conjugates (adc) that bind 191p4d12 proteins in combination with pembrolizumab |
| KR20250044313A (ko) | 2022-07-27 | 2025-03-31 | 아스트라제네카 아베 | Pd-1/pd-l1 저해제와 인터루킨-12를 발현하는 재조합 바이러스의 조합물 |
| AU2023313120A1 (en) | 2022-07-28 | 2025-02-06 | Astrazeneca Uk Limited | Combination of antibody-drug conjugate and bispecific checkpoint inhibitor |
| WO2024028794A1 (en) | 2022-08-02 | 2024-02-08 | Temple Therapeutics BV | Methods for treating endometrial and ovarian hyperproliferative disorders |
| US20240043560A1 (en) | 2022-08-02 | 2024-02-08 | Regeneron Pharmaceuticals, Inc. | Methods of Treating Metastatic Castration-Resistant Prostate Cancer with Bispecific Anti-PSMA x Anti-CD28 Antibodies in Combination with Anti-PD-1 Antibodies |
| WO2024028386A1 (en) | 2022-08-02 | 2024-02-08 | Ose Immunotherapeutics | Multifunctional molecule directed against cd28 |
| AU2023320568A1 (en) | 2022-08-05 | 2025-02-06 | Juno Therapeutics, Inc. | Chimeric antigen receptors specific for gprc5d and bcma |
| WO2024033400A1 (en) | 2022-08-10 | 2024-02-15 | Institut National de la Santé et de la Recherche Médicale | Sk2 inhibitor for the treatment of pancreatic cancer |
| WO2024033399A1 (en) | 2022-08-10 | 2024-02-15 | Institut National de la Santé et de la Recherche Médicale | Sigmar1 ligand for the treatment of pancreatic cancer |
| WO2024040175A1 (en) | 2022-08-18 | 2024-02-22 | Pulmatrix Operating Company, Inc. | Methods for treating cancer using inhaled angiogenesis inhibitor |
| JPWO2024043227A1 (enExample) | 2022-08-23 | 2024-02-29 | ||
| JPWO2024043319A1 (enExample) | 2022-08-26 | 2024-02-29 | ||
| WO2024054418A1 (en) * | 2022-09-08 | 2024-03-14 | Cugene Inc. | Sequence optimization of a pd1 blocking antibody |
| EP4587040A1 (en) | 2022-09-14 | 2025-07-23 | Institut National de la Santé et de la Recherche Médicale | Methods and pharmaceutical compositions for the treatment of dilated cardiomyopathy |
| JP2025532209A (ja) | 2022-09-26 | 2025-09-29 | アンスティテュ・クリー | Ｉｌ－２を発現する骨髄系細胞及び迅速な抗癌療法のためのその使用 |
| CN120379691A (zh) | 2022-09-30 | 2025-07-25 | 爱兰蒂斯疗法股份公司 | 耐药性肝细胞癌的治疗 |
| KR20250099774A (ko) | 2022-10-03 | 2025-07-02 | 리제너론 파아마슈티컬스, 인크. | 이중특이적 egfr x cd28 항체를 단독으로 또는 항-pd-1 항체와 조합하여 사용하여 암을 치료하는 방법 |
| EP4598946A1 (en) | 2022-10-05 | 2025-08-13 | Flagship Pioneering Innovations V, Inc. | Nucleic acid molecules encoding trif and additionalpolypeptides and their use in treating cancer |
| CN119997975A (zh) | 2022-10-19 | 2025-05-13 | 安斯泰来制药株式会社 | 抗cldn4-抗cd137双特异性抗体通过与pd-1信号抑制剂的组合在癌症治疗中的应用 |
| JP2025536252A (ja) | 2022-10-20 | 2025-11-05 | アンセルム（アンスティチュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル） | 癌治療のための併用療法 |
| EP4605422A2 (en) | 2022-10-20 | 2025-08-27 | Repertoire Immune Medicines, Inc. | Cd8 t cell targeted il2 |
| EP4605000A1 (en) | 2022-10-21 | 2025-08-27 | Institut National de la Santé et de la Recherche Médicale | Methods and pharmaceutical compositions for the treatment of osteoarthritis |
| EP4608995A1 (en) | 2022-10-24 | 2025-09-03 | Memorial Sloan-Kettering Cancer Center | Tumour stratification for responsiveness to an immune checkpoint inhibitor |
| WO2024089418A1 (en) | 2022-10-24 | 2024-05-02 | Cancer Research Technology Limited | Tumour sensitisation to checkpoint inhibitors with redox status modifier |
| CN116041539B (zh) * | 2022-10-31 | 2023-07-21 | 山东博安生物技术股份有限公司 | Il-2突变体免疫缀合物 |
| EP4611897A1 (en) | 2022-11-01 | 2025-09-10 | Heidelberg Pharma Research GmbH | Anti-gucy2c antibody and uses thereof |
| KR20250089492A (ko) | 2022-11-07 | 2025-06-18 | 네오이뮨텍, 인코퍼레이티드 | 비메틸화된 mgmt 프로모터를 갖는 종양의 치료 방법 |
| WO2024108100A1 (en) | 2022-11-18 | 2024-05-23 | Incyte Corporation | Heteroaryl fluoroalkenes as dgk inhibitors |
| CN120584182A (zh) | 2022-11-21 | 2025-09-02 | 艾欧凡斯生物治疗公司 | 肿瘤浸润淋巴细胞扩增的二维过程及其疗法 |
| AU2023383923A1 (en) | 2022-11-24 | 2025-07-10 | Beone Medicines I Gmbh | Anti-cea antibody drug conjugates and methods of use |
| EP4613780A4 (en) | 2022-11-29 | 2025-12-31 | Adlai Nortye Biopharma Co Ltd | Fusion Polypeptide and its Use |
| JP2025541738A (ja) | 2022-12-01 | 2025-12-23 | ビオンテック・ソシエタス・エウロパエア | 抗ｐｄ１ａｂと化学療法での併用療法におけるｃｄ４０およびｃｄ１３７に対する多重特異性抗体 |
| JP2025539459A (ja) | 2022-12-01 | 2025-12-05 | イナート・ファルマ・ソシエテ・アノニム | 癌におけるネオアジュバント処置のための組成物および方法 |
| CN120390652A (zh) | 2022-12-01 | 2025-07-29 | 免疫医疗有限公司 | 用于治疗癌症的包含抗pd-l1抗体和抗cd73抗体的组合疗法 |
| EP4633664A2 (en) | 2022-12-13 | 2025-10-22 | Juno Therapeutics, Inc. | Chimeric antigen receptors specific for baff-r and cd19 and methods and uses thereof |
| EP4634224A1 (en) | 2022-12-14 | 2025-10-22 | Astellas Pharma Europe Bv | Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and immune checkpoint inhibitors |
| AU2023409221A1 (en) | 2022-12-21 | 2025-06-12 | Bristol-Myers Squibb Company | Combination therapy for lung cancer |
| WO2024151687A1 (en) | 2023-01-09 | 2024-07-18 | Flagship Pioneering Innovations V, Inc. | Genetic switches and their use in treating cancer |
| WO2024150177A1 (en) | 2023-01-11 | 2024-07-18 | Advesya | Treatment methods for solid tumors |
| US20240270739A1 (en) | 2023-01-12 | 2024-08-15 | Incyte Corporation | Heteroaryl Fluoroalkenes As DGK Inhibitors |
| WO2024151885A1 (en) | 2023-01-13 | 2024-07-18 | Iovance Biotherapeutics, Inc. | Use of til as maintenance therapy for nsclc patients who achieved pr/cr after prior therapy |
| IL322127A (en) | 2023-01-19 | 2025-09-01 | Beone Medicines I Gmbh | Anti-cmet antibodies and methods of use |
| AR131654A1 (es) | 2023-01-20 | 2025-04-16 | Boehringer Ingelheim Int | PROTEÍNAS DE FUSIÓN Fc DE IL-12 |
| WO2024160721A1 (en) | 2023-01-30 | 2024-08-08 | Kymab Limited | Antibodies |
| WO2024163477A1 (en) | 2023-01-31 | 2024-08-08 | University Of Rochester | Immune checkpoint blockade therapy for treating staphylococcus aureus infections |
| AU2024225483A1 (en) | 2023-02-23 | 2025-08-28 | Imcheck Therapeutics | Combination of btn3a activating antibody and immune checkpoint inhibitors |
| TW202436354A (zh) | 2023-03-06 | 2024-09-16 | 瑞士商百濟神州瑞士有限責任公司 | 抗cldn6抗體以及其使用方法 |
| TW202436345A (zh) | 2023-03-06 | 2024-09-16 | 瑞士商百濟神州瑞士有限責任公司 | 抗ｃｄ３多特異性抗體及使用方法 |
| WO2024184810A1 (en) | 2023-03-06 | 2024-09-12 | Beigene Switzerland Gmbh | Anti-cldn6 and anti-cd3 multispecific antibodies and methods of use |
| WO2024184417A1 (en) | 2023-03-07 | 2024-09-12 | Photocure Asa | Therapy for bladder cancer |
| WO2024192051A1 (en) | 2023-03-13 | 2024-09-19 | Turnstone Biologics Corp. | Composition of selected tumor infiltrating lymphocytes and related methods of producing and using the same |
| KR20250155054A (ko) | 2023-03-13 | 2025-10-29 | 리제너론 파마슈티칼스 인코포레이티드 | 흑색종 치료에서의 효능 강화를 위한 pd-1 억제제와 lag-3 억제제의 병용 |
| WO2024188965A1 (en) | 2023-03-13 | 2024-09-19 | F. Hoffmann-La Roche Ag | Combination therapy employing a pd1-lag3 bispecific antibody and an hla-g t cell bispecific antibody |
| WO2024189048A1 (en) | 2023-03-13 | 2024-09-19 | Heidelberg Pharma Research Gmbh | Subcutaneously administered antibody-drug conjugates for use in cancer treatment |
| WO2024196952A1 (en) | 2023-03-20 | 2024-09-26 | Bristol-Myers Squibb Company | Tumor subtype assessment for cancer therapy |
| CN121263449A (zh) | 2023-03-21 | 2026-01-02 | 拜格拉夫55公司 | Cd19/cd38多特异性抗体 |
| WO2024194402A1 (en) | 2023-03-21 | 2024-09-26 | Institut Curie | Farnesyl transferase inhibitor for use in methods for the treatment of hrd cancer |
| WO2024194673A1 (en) | 2023-03-21 | 2024-09-26 | Institut Curie | Methods for the treatment of dedifferentiated liposarcoma |
| WO2024194401A1 (en) | 2023-03-21 | 2024-09-26 | Institut Curie | Vps4b inhibitor for use in methods for the treatment of hrd cancer |
| WO2024200571A1 (en) | 2023-03-28 | 2024-10-03 | Institut National de la Santé et de la Recherche Médicale | Method for discriminating mono-immunotherapy from combined immunotherapy in cancers |
| CN120917143A (zh) | 2023-03-29 | 2025-11-07 | 第一三共株式会社 | 抗cd25抗体及抗cd25抗体-药物偶联物 |
| US20240336608A1 (en) | 2023-03-29 | 2024-10-10 | Merck Sharp & Dohme Llc | Il4i1 inhibitors and methods of use |
| WO2024209072A1 (en) | 2023-04-06 | 2024-10-10 | Genmab A/S | Multispecific binding agents against pd-l1 and cd137 for treating cancer |
| WO2024215787A1 (en) | 2023-04-11 | 2024-10-17 | Ngm Biopharmaceuticals, Inc. | Methods of treating osteosarcoma using lair1 binding agents and pd-1 antagonists |
| WO2024216028A1 (en) | 2023-04-12 | 2024-10-17 | Agenus Inc. | Methods of treating cancer using an anti-ctla4 antibody and an enpp1 inhibitor |
| WO2024213533A1 (en) | 2023-04-13 | 2024-10-17 | Alligator Bioscience Ab | Combination therapies |
| WO2024213782A1 (en) | 2023-04-13 | 2024-10-17 | Institut Curie | Methods for the treatment of t-cell acute lymphoblastic leukemia |
| AU2024258965A1 (en) | 2023-04-18 | 2025-11-06 | Incyte Corporation | 2-azabicyclo[2.2.1]heptane kras inhibitors |
| WO2024220532A1 (en) | 2023-04-18 | 2024-10-24 | Incyte Corporation | Pyrrolidine kras inhibitors |
| WO2024223299A2 (en) | 2023-04-26 | 2024-10-31 | Isa Pharmaceuticals B.V. | Methods of treating cancer by administering immunogenic compositions and a pd-1 inhibitor |
| WO2024228167A1 (en) | 2023-05-03 | 2024-11-07 | Iox Therapeutics Inc. | Inkt cell modulator liposomal compositions and methods of use |
| TW202509069A (zh) | 2023-05-04 | 2025-03-01 | 美商諾瓦森塔股份有限公司 | 抗cd161抗體及其使用方法 |
| WO2024231384A1 (en) | 2023-05-10 | 2024-11-14 | Institut National de la Santé et de la Recherche Médicale | Compositions for treating senescence related disease |
| US12410258B2 (en) | 2023-05-12 | 2025-09-09 | Ganmab A/S | Antibodies capable of binding to OX40, variants thereof and uses thereof |
| WO2024236048A1 (en) | 2023-05-16 | 2024-11-21 | Nh Theraguix | Combination therapy for treating tumors with radiotherapy |
| WO2024245951A1 (en) | 2023-05-26 | 2024-12-05 | Institut National de la Santé et de la Recherche Médicale | Combination of slc8a1 inhibitor and mitochondria-targeted antioxidant for treating melanoma |
| WO2024254245A1 (en) | 2023-06-09 | 2024-12-12 | Incyte Corporation | Bicyclic amines as cdk2 inhibitors |
| WO2024256635A1 (en) | 2023-06-15 | 2024-12-19 | Institut National de la Santé et de la Recherche Médicale | Dpm1 inhibitor for treating cancer |
| WO2024261239A1 (en) | 2023-06-23 | 2024-12-26 | Imcheck Therapeutics | Bispecific antibodies targeting btn3a and the pd-1/pd-l1 inhibitory axis |
| WO2025006811A1 (en) | 2023-06-27 | 2025-01-02 | Lyell Immunopharma, Inc. | Methods for culturing immune cells |
| CA3221817A1 (en) * | 2023-06-30 | 2025-06-13 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Combination therapies for the treatment of cancer |
| IL304887A (en) | 2023-07-31 | 2025-02-01 | Yeda Res & Dev | T-cell receptor directed against RAS neoantigen |
| WO2025030044A1 (en) | 2023-08-02 | 2025-02-06 | Regeneron Pharmaceuticals, Inc. | Methods of treating clear cell renal cell carcinoma with bispecific anti-psma x anti-cd28 antibodies |
| WO2025030041A1 (en) | 2023-08-02 | 2025-02-06 | Regeneron Pharmaceuticals, Inc. | Methods of treating metastatic castration-resistant prostate cancer with bispecific anti-psma x anti-cd28 antibodies |
| WO2025034883A1 (en) | 2023-08-08 | 2025-02-13 | Quanta Therapeutics, Inc. | Combination therapies with kras modulators |
| US20250099605A1 (en) | 2023-08-15 | 2025-03-27 | Gilead Sciences, Inc. | Treatment of non-small cell lung cancer using sacituzumab govitecan and an anti-pd-1 antibody or antigen binding fragment thereof |
| WO2025038763A1 (en) | 2023-08-15 | 2025-02-20 | Bristol-Myers Squibb Company | Ceramic hydroxyapatite chromatography flow through method |
| WO2025042742A1 (en) | 2023-08-18 | 2025-02-27 | Bristol-Myers Squibb Company | Compositions comprising antibodies that bind bcma and cd3 and methods of treatment |
| WO2025043151A2 (en) | 2023-08-24 | 2025-02-27 | Incyte Corporation | Bicyclic dgk inhibitors |
| WO2025050009A2 (en) | 2023-09-01 | 2025-03-06 | Children's Hospital Medical Center | Identification of targets for immunotherapy in melanoma using splicing-derived neoantigens |
| WO2025049858A1 (en) | 2023-09-01 | 2025-03-06 | Amgen Inc. | Molecules for treatment of cancer |
| US20250075000A1 (en) | 2023-09-06 | 2025-03-06 | Novimmune Sa | Combination therapy with a cea x cd28 bispecific antibody and blocking anti-pd-1 antibodies for enhanced in vivo anti-tumor activity |
| WO2025056180A1 (en) | 2023-09-15 | 2025-03-20 | BioNTech SE | Methods of treatment using agents binding to epcam and cd137 in combination with pd-1 axis binding antagonists |
| WO2025068393A1 (en) | 2023-09-27 | 2025-04-03 | Institut Curie | Methods for the treatment of fibrotic related diseases |
| WO2025073765A1 (en) | 2023-10-03 | 2025-04-10 | Institut National de la Santé et de la Recherche Médicale | Methods of prognosis and treatment of patients suffering from melanoma |
| WO2025077212A1 (zh) * | 2023-10-08 | 2025-04-17 | 广东菲鹏制药股份有限公司 | 抗pd1-il10融合蛋白及其应用 |
| WO2025080538A1 (en) | 2023-10-09 | 2025-04-17 | Regeneron Pharmaceuticals, Inc. | Methods of treating cancer with a combination of a pd1 inhibitor and a targeted immunocytokine |
| WO2025080593A1 (en) | 2023-10-09 | 2025-04-17 | Incyte Corporation | Combination therapy using a kras g12d inhibitor and pd-1 inhibitor or pd-l1 inhibitor |
| WO2025080865A1 (en) | 2023-10-11 | 2025-04-17 | Turnstone Biologics Corp. | Combination of tumor infiltrating lymphocytes (til) and low dose radiation |
| WO2025078632A1 (en) | 2023-10-12 | 2025-04-17 | Institut National de la Santé et de la Recherche Médicale | Methods of prognosis and treatment of patients suffering from cancer |
| TW202515903A (zh) | 2023-10-12 | 2025-04-16 | 瑞士商百濟神州瑞士有限責任公司 | 手術前後基於抗ｐｄ－１之治療 |
| US20250135019A1 (en) | 2023-10-13 | 2025-05-01 | Gilead Sciences, Inc. | Combination therapies for treating cancers |
| WO2025096638A2 (en) | 2023-10-30 | 2025-05-08 | Turnstone Biologics Corp. | Genetically modified tumor infilitrating lymphocytes and methods of producing and using the same |
| US20250163079A1 (en) | 2023-11-01 | 2025-05-22 | Incyte Corporation | Kras inhibitors |
| WO2025093824A1 (en) | 2023-11-02 | 2025-05-08 | Tilt Biotherapeutics Oy | Oncolytic adenovirus, immune checkpoint inhibitor and chemoterapeutic agent combination therapy of cancer |
| WO2025096843A1 (en) | 2023-11-03 | 2025-05-08 | Amgen Inc. | Bispecific molecules |
| WO2025106736A2 (en) | 2023-11-15 | 2025-05-22 | Regeneron Pharmaceuticals, Inc. | Combination of pd-1 inhibitors and lag-3 inhibitors for enhanced efficacy in treating lung cancer |
| WO2025106905A1 (en) | 2023-11-17 | 2025-05-22 | Quanta Therapeutics, Inc. | Combination therapies with a kras modulator and an immunomodulator inhibitor |
| WO2025109597A1 (en) | 2023-11-22 | 2025-05-30 | Yeda Research And Development Co. Ltd. | T cell receptors directed against androgen receptor mutation |
| TW202539732A (zh) | 2023-11-29 | 2025-10-16 | 美商再生元醫藥公司 | 以雙特異性抗muc16×抗cd28抗體與抗pd-1抗體之組合或與雙特異性抗muc16×抗cd3抗體之組合治療復發性卵巢癌及子宮內膜癌之方法 |
| WO2025114541A1 (en) | 2023-11-30 | 2025-06-05 | Genmab A/S | Antibodies capable of binding to ox40 in combination therapy |
| TW202523667A (zh) | 2023-12-05 | 2025-06-16 | 美商英塞特公司 | 作為ｄｇｋ抑制劑之三環三唑并化合物 |
| US20250186450A1 (en) | 2023-12-06 | 2025-06-12 | Incyte Corporation | COMBINATION THERAPY COMPRISING DGK INHIBITORS and PD-1/PD-L1 INHIBITORS |
| WO2025121445A1 (en) | 2023-12-08 | 2025-06-12 | Astellas Pharma Inc. | Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and agents stabilizing or increasing expression of cldn18.2 |
| WO2025120867A1 (en) | 2023-12-08 | 2025-06-12 | Astellas Pharma Inc. | Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and anti-vegfr2 antibodies |
| WO2025120866A1 (en) | 2023-12-08 | 2025-06-12 | Astellas Pharma Inc. | Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and agents stabilizing or increasing expression of cldn18.2 |
| WO2025128465A1 (en) * | 2023-12-12 | 2025-06-19 | Merck Sharp & Dohme Llc | Methods of purifying anti-pd-1 antibodies or antigen-binding fragments thereof using mixed-mode anion-exchange chromatography |
| WO2025128652A1 (en) | 2023-12-12 | 2025-06-19 | Regeneron Pharmaceuticals, Inc. | Methods of treating endometrial cancer with bispecific anti-muc16 x anti-cd3 antibodies alone or in combination with anti-pd-1 antibodies |
| US20250195536A1 (en) | 2023-12-13 | 2025-06-19 | Incyte Corporation | Bicyclooctane kras inhibitors |
| WO2025132479A1 (en) | 2023-12-18 | 2025-06-26 | Institut National de la Santé et de la Recherche Médicale | Flt3 inhibitor for modulating macrophages polarization |
| WO2025132695A1 (en) | 2023-12-19 | 2025-06-26 | Boehringer Ingelheim International Gmbh | Recombinant rhabdovirus encoding for a gasdermin |
| WO2025137093A1 (en) | 2023-12-19 | 2025-06-26 | Cephalon Llc | Uses for attenuated il-2 immunoconjugates |
| EP4574165A1 (en) | 2023-12-21 | 2025-06-25 | Egle Therapeutics | Immunocytokine for cancer treatment |
| WO2025133175A1 (en) | 2023-12-21 | 2025-06-26 | Egle Therapeutics | Immunocytokine for cancer treatment |
| WO2025132770A1 (en) | 2023-12-22 | 2025-06-26 | Institut National de la Santé et de la Recherche Médicale | Affitins for the treatment of cancer |
| US20250215087A1 (en) | 2023-12-29 | 2025-07-03 | Bristol-Myers Squibb Company | Combination therapy of kras inhibitor and treg depleting agent |
| WO2025146131A1 (en) | 2024-01-05 | 2025-07-10 | Beigene, Ltd. | ANTI-FGFR2b ANTIBODIES, CONJUGATES AND METHODS OF USE |
| WO2025151487A2 (en) | 2024-01-08 | 2025-07-17 | Regents Of The University Of Michigan | Small-molecule inhibitors of adar1 |
| WO2025151800A1 (en) | 2024-01-10 | 2025-07-17 | Autonomous Therapeutics, Inc. | Programmable, rna editor-controlled nucleic acid dose amplifiers and their methods of use |
| WO2025151803A1 (en) | 2024-01-10 | 2025-07-17 | Autonomous Therapeutics, Inc. | Alphaviral encrypted rnas and their methods of use |
| WO2025153834A1 (en) | 2024-01-19 | 2025-07-24 | Institut National de la Santé et de la Recherche Médicale | Methods of predicting the risk of recurrence and/or death of patients suffering from a hepatocellular carcinoma (hcc) |
| WO2025158077A1 (en) | 2024-01-26 | 2025-07-31 | Institut Curie | Lipid degraders to trigger ferroptosis in cancer |
| WO2025163468A1 (en) | 2024-01-30 | 2025-08-07 | Seagen Inc. | Anti-pd-l1 antibodies and antibody-drug conjugates and their use in the treatment of cancer |
| WO2025170888A1 (en) | 2024-02-05 | 2025-08-14 | Signalchem Lifesciences Corporation | A combination of the axl inhibitor slc-391 and a pd-1 inhibitor for use in the treatment of blood cancer |
| WO2025174825A2 (en) | 2024-02-12 | 2025-08-21 | Aera Therapeutics, Inc. | Delivery compositions |
| TW202539744A (zh) | 2024-02-27 | 2025-10-16 | 美商必治妥美雅史谷比公司 | 抗ｃｅａｃａｍ５抗體藥物軛合物 |
| WO2025184208A1 (en) | 2024-02-27 | 2025-09-04 | Bristol-Myers Squibb Company | Anti-ceacam5 antibodies and uses thereof |
| WO2025191529A1 (en) | 2024-03-14 | 2025-09-18 | Biohaven Therapeutics Ltd. | Next generation riluzole prodrugs |
| WO2025202213A1 (en) | 2024-03-26 | 2025-10-02 | Institut National de la Santé et de la Recherche Médicale | Lipid nanoparticle loaded with antitumoral agent and functionnalized to target immosuppressive cells |
| WO2025207705A1 (en) | 2024-03-26 | 2025-10-02 | Amgen Inc. | Cancer treatments using mta-cooperative prmt5 inhibitors |
| WO2025202971A1 (en) | 2024-03-27 | 2025-10-02 | Novartis Ag | Kras g12c inhibitor for use for the treatment of non-small cell lung cancer |
| WO2025203012A1 (en) | 2024-03-27 | 2025-10-02 | Novartis Ag | Kras g12c inhibitor for use for the treatment of non-small cell lung cancer |
| WO2025202450A1 (en) | 2024-03-28 | 2025-10-02 | Institut Curie | Myeloid cells modified by cytokine chimeric receptor and uses thereof |
| EP4624494A1 (en) | 2024-03-29 | 2025-10-01 | Institut Curie | Her2 single domain antibody and uses thereof |
| WO2025210123A1 (en) | 2024-04-03 | 2025-10-09 | Institut National de la Santé et de la Recherche Médicale | Methods and pharmaceutical composition for treating cancers |
| WO2025213154A1 (en) | 2024-04-05 | 2025-10-09 | Amgen Inc. | Gastrointestinal cancer treatments using mta-cooperative prmt5 inhibitors |
| WO2025210252A1 (en) | 2024-04-05 | 2025-10-09 | Institut Curie | Modulators of fam118b protein for use in therapy |
| WO2025219330A1 (en) | 2024-04-15 | 2025-10-23 | Institut National de la Santé et de la Recherche Médicale | Detection of ppix for use in methods for melanoma ferroptosis sensitivity and targeted therapy resistance prediction |
| WO2025219595A1 (en) | 2024-04-19 | 2025-10-23 | Biper Therapeutics | Method for combination treatments using alkynylbenzenesulphonamides for cancer therapy |
| WO2025223372A1 (en) | 2024-04-22 | 2025-10-30 | Fujian Haixi Pharmaceuticals Co., Ltd. | Combination comprising a pd-1 inhibitor and a pyridine compound for use in treating solid tumors |
| WO2025228998A1 (en) | 2024-04-30 | 2025-11-06 | Institut National de la Santé et de la Recherche Médicale | Use of hdac4 inhibitors for the treatment of melanoma |
| WO2025233224A1 (en) | 2024-05-09 | 2025-11-13 | F. Hoffmann-La Roche Ag | Use of atr inhibitors in combination with anti-pd(l)1 therapy |
| WO2025232879A1 (en) | 2024-05-10 | 2025-11-13 | Cytocares (Shanghai) Inc. | Anti-lilrb2 monospecific and bispecific antibody constructs and uses thereof |
| WO2025240670A2 (en) | 2024-05-15 | 2025-11-20 | Abalytics Oncology, Inc. | Anti-pd-1 antibodies and related binding molecules and methods and uses thereof |
| WO2025245256A1 (en) | 2024-05-22 | 2025-11-27 | Tizona Therapeutics, Inc. | Combination therapy involving anti-hla-g antibodies and anti- egfr antibodies or anti-pd-1 antibodies |
| WO2025242910A1 (en) | 2024-05-23 | 2025-11-27 | Egle Therapeutics | Il18r agonist antibodies and uses thereof |
| EP4653460A1 (en) | 2024-05-23 | 2025-11-26 | Egle Therapeutics | Il18r agonist antibodies and uses thereof |
| WO2025245489A1 (en) | 2024-05-24 | 2025-11-27 | Bristol-Myers Squibb Company | Treatment of tumors in subjects having fgl-1 positive samples |
| WO2025247829A1 (en) | 2024-05-27 | 2025-12-04 | Institut National de la Santé et de la Recherche Médicale | Methods and pharmaceutical composition for treating prostate cancer |
| WO2025248505A1 (en) | 2024-05-31 | 2025-12-04 | Wayne State University | Methods for treating endometrial and ovarian hyperproliferative disorders |
| WO2025252857A1 (en) | 2024-06-05 | 2025-12-11 | Institut National de la Santé et de la Recherche Médicale | Il-15 muteins with ph-dependent binding for il-15ralpha |
| WO2025252855A1 (en) | 2024-06-05 | 2025-12-11 | Institut National de la Santé et de la Recherche Médicale | IL-15 MUTEINS WITH PH-DEPENDENT BINDING FOR IL-15Rbeta |
| WO2025257220A1 (en) | 2024-06-10 | 2025-12-18 | Merck Patent Gmbh | Muc-1 conditional cd40 agonists |
| WO2025257588A1 (en) | 2024-06-10 | 2025-12-18 | Affimed Gmbh | Cd16a/tumor antigen polyspecific binder for use in the treatment of immune checkpoint inhibitor resistance |
| GB202408360D0 (en) | 2024-06-11 | 2024-07-24 | Cancer Research Tech Ltd | Tumour sensitisation |
| WO2025259515A2 (en) | 2024-06-11 | 2025-12-18 | Amgen Inc. | Combination treatment |
| WO2026003224A2 (en) | 2024-06-26 | 2026-01-02 | Iomx Therapeutics Ag | Bispecific antigen binding proteins (abp) targeting immune checkpoint molecules and both leukocyte immunoglobulin-like receptor subfamily b1 (lilrb1) and lilrb2; combinations and uses thereof |
| WO2026006604A1 (en) | 2024-06-26 | 2026-01-02 | Lyell Immunopharma, Inc. | Feeder cell replacement |
Family Cites Families (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| EP0281604B1 (en) | 1986-09-02 | 1993-03-31 | Enzon Labs Inc. | Single polypeptide chain binding molecules |
| US5260203A (en) | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| US5859205A (en) * | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| ATE297465T1 (de) | 1991-11-25 | 2005-06-15 | Enzon Inc | Verfahren zur herstellung von multivalenten antigenbindenden proteinen |
| IL108501A (en) * | 1994-01-31 | 1998-10-30 | Mor Research Applic Ltd | Antibodies and pharmaceutical compositions containing them |
| CA2143491C (en) * | 1994-03-01 | 2011-02-22 | Yasumasa Ishida | A novel peptide related to human programmed cell death and dna encoding it |
| IL129299A0 (en) | 1999-03-31 | 2000-02-17 | Mor Research Applic Ltd | Monoclonal antibodies antigens and diagnosis of malignant diseases |
| BR0013542A (pt) | 1999-08-23 | 2002-05-14 | Dana Farber Cancer Inst Inc | Moléculas b7-4 e usos para as mesmas |
| DK1210428T3 (en) * | 1999-08-23 | 2015-06-15 | Dana Farber Cancer Inst Inc | PD-1, a receptor for B7-4 AND USE THEREOF |
| EP2388590A1 (en) | 2001-04-02 | 2011-11-23 | Dana Farber Cancer Institute | PD-1, a receptor for B7-4, and uses thereof |
| AR036993A1 (es) * | 2001-04-02 | 2004-10-20 | Wyeth Corp | Uso de agentes que modulan la interaccion entre pd-1 y sus ligandos en la submodulacion de respuestas inmunologicas |
| US7794710B2 (en) * | 2001-04-20 | 2010-09-14 | Mayo Foundation For Medical Education And Research | Methods of enhancing T cell responsiveness |
| EP1445264B1 (en) * | 2001-07-31 | 2011-09-14 | Ono Pharmaceutical Co., Ltd. | Substance specific to pd-1 |
| IL149820A0 (en) | 2002-05-23 | 2002-11-10 | Curetech Ltd | Humanized immunomodulatory monoclonal antibodies for the treatment of neoplastic disease or immunodeficiency |
| EP2243493A1 (en) * | 2002-07-03 | 2010-10-27 | Ono Pharmaceutical Co., Ltd. | Immunopotentiative composition |
| BR0316880A (pt) * | 2002-12-23 | 2005-10-25 | Wyeth Corp | Anticorpos contra pd-1 e usos dos mesmos |
| US7563869B2 (en) | 2003-01-23 | 2009-07-21 | Ono Pharmaceutical Co., Ltd. | Substance specific to human PD-1 |
| SI3428191T1 (sl) | 2004-10-06 | 2025-03-31 | Mayo Foundation For Medical Education And Research | B7-H1 in PD-1 v zdravljenju karcinoma ledvičnih celic |
| CA2970873C (en) * | 2005-05-09 | 2022-05-17 | E. R. Squibb & Sons, L.L.C. | Human monoclonal antibodies to programmed death 1 (pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics |
| MX351401B (es) * | 2005-06-08 | 2017-10-13 | Dana Farber Cancer Inst Inc | Metodos y composiciones para el tratamiento de infecciones persistentes y cancer por inhibicion de la ruta de muerte celular programada (pd-1). |
| EA019344B1 (ru) | 2005-07-01 | 2014-03-31 | МЕДАРЕКС, Эл.Эл.Си. | Человеческие моноклональные антитела против лиганда-1 запрограммированной гибели клеток (pd-l1) и их применения |
| US20090215084A1 (en) | 2006-01-05 | 2009-08-27 | Mayo Foundation For Medical Education And Research | B7-h1 and b7-h4 in cancer |
| AU2007331672A1 (en) | 2006-12-15 | 2008-06-19 | Ablynx N.V. | Amino acid sequences that modulate the interaction between cells of the immune system |
| SI2170959T1 (sl) * | 2007-06-18 | 2014-04-30 | Merck Sharp & Dohme B.V. | Protitelesa proti receptorjem pd-1 za humano programirano smrt |
| US8168757B2 (en) * | 2008-03-12 | 2012-05-01 | Merck Sharp & Dohme Corp. | PD-1 binding proteins |
| BRPI0919377A2 (pt) | 2008-09-26 | 2016-09-27 | Dana Farber Cancer Inst Inc | anticorpo isolado ou um fragmento ligante de antígeno do memso, ácido nucleico isolado, vetor, célula hospedeira, composição farmacêutica, método de produzir o referido anticorpo ou fragmento, uso dos mesmos, e composição compreendendo o referido anticorpo ou fragmento |
| PL2691112T3 (pl) * | 2011-03-31 | 2018-09-28 | Merck Sharp & Dohme Corp. | Stabilne preparaty przeciwciał przeciw ludzkiemu receptorowi programowanej śmierci pd-1 i terapie powiązane |
| WO2014158811A1 (en) | 2013-03-14 | 2014-10-02 | Icahn School Of Medicine At Mount Sinai | Newcastle disease viruses and uses thereof |
| US20160084839A1 (en) | 2013-04-02 | 2016-03-24 | Marisa Dolled-Filhart | Immunohistochemical assay for detecting expression of programmed death ligand 1 (pd-l1) in tumor tissue |
| EP3003316B1 (en) * | 2013-05-31 | 2020-07-22 | Merck Sharp & Dohme Corp. | Combination therapies for cancer |
| WO2015026634A1 (en) * | 2013-08-20 | 2015-02-26 | Merck Sharp & Dohme Corp. | Treating cancer with a combination of a pd-1 antagonist and dinaciclib |
| AR097306A1 (es) | 2013-08-20 | 2016-03-02 | Merck Sharp & Dohme | Modulación de la inmunidad tumoral |
| US10241115B2 (en) * | 2013-12-10 | 2019-03-26 | Merck Sharp & Dohme Corp. | Immunohistochemical proximity assay for PD-1 positive cells and PD-ligand positive cells in tumor tissue |
| EP3102604B1 (en) | 2014-02-04 | 2020-01-15 | Pfizer Inc | Combination of a pd-1 antagonist and a 4-1bb agonist for treating cancer |
| AU2015214404B2 (en) | 2014-02-04 | 2020-10-01 | Incyte Corporation | Combination of a PD-1 antagonist and an IDO1 inhibitor for treating cancer |
| DK3102605T3 (en) | 2014-02-04 | 2019-02-25 | Pfizer | COMBINATION OF A PD-1 ANTAGONIST AND A VEGFR INHIBITOR FOR TREATMENT OF CANCER |
| US9907849B2 (en) * | 2014-07-18 | 2018-03-06 | Advaxis, Inc. | Combination of a PD-1 antagonist and a listeria-based vaccine for treating prostate cancer |
| JO3663B1 (ar) | 2014-08-19 | 2020-08-27 | Merck Sharp & Dohme | الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين |
| WO2016028656A1 (en) | 2014-08-19 | 2016-02-25 | Merck Sharp & Dohme Corp. | Anti-tigit antibodies |
| EP3185866A1 (en) | 2014-08-25 | 2017-07-05 | Pfizer Inc. | Combination of a pd-1 antagonist and an alk inhibitor for treating cancer |
| EP3215156B1 (en) | 2014-11-03 | 2025-09-24 | Iomet Pharma Ltd. | Inhibitors of tryptophan-2,3-dioxygenase or indoleamine-2,3-dioxygenase |
| CN107109700A (zh) | 2014-12-09 | 2017-08-29 | 默沙东公司 | 用于推导对pd‑1拮抗剂的反应的基因特征生物标志物的系统和方法 |
| AR103726A1 (es) | 2015-02-27 | 2017-05-31 | Merck Sharp & Dohme | Cristales de anticuerpos monoclonales anti-pd-1 humanos |
| KR20250020678A (ko) | 2015-03-04 | 2025-02-11 | 머크 샤프 앤드 돔 엘엘씨 | 암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합 |
| KR20170122810A (ko) | 2015-03-04 | 2017-11-06 | 머크 샤프 앤드 돔 코포레이션 | 암을 치료하기 위한 pd-1 길항제 및 에리불린의 조합 |
| EP3283882B2 (en) | 2015-04-17 | 2024-10-16 | Merck Sharp & Dohme LLC | Blood-based biomarkers of tumor sensitivity to pd-1 antagonists |
| WO2016168510A1 (en) | 2015-04-17 | 2016-10-20 | Peloton Therapeutics, Inc. | Combination therapy of a hif-2-alpha inhibitor and an immunotherapeutic agent and uses thereof |
| EP3892284B1 (en) | 2015-05-29 | 2024-05-22 | Merck Sharp & Dohme LLC | Combination of a pd-1 antagonist and a cpg-c type oligonucleotide for treating cancer |
| CN108290936B (zh) | 2015-08-14 | 2022-07-12 | 默沙东公司 | 抗tigit抗体 |
| EP3352858A4 (en) | 2015-09-21 | 2019-04-17 | Merck Sharp & Dohme Corp. | ANTIBODIES BINDING TO HUMAN PROGRAMMED DEATH LIGANDS 2 (PD-L2) AND USE THEREOF |
| TWI754622B (zh) | 2015-11-18 | 2022-02-11 | 美商默沙東藥廠 | Ctla4結合劑 |
| HK1254951A1 (zh) | 2015-11-18 | 2019-08-02 | Merck Sharp & Dohme Llc | Pd1和/或lag3结合剂 |
| WO2017205216A1 (en) | 2016-05-23 | 2017-11-30 | Eli Lilly And Company | Combination of pembrolizumab and abemaciclib for the treatment of cancer |
| WO2017210119A1 (en) | 2016-06-03 | 2017-12-07 | Imclone Llc | Combination of ramucirumab and pembrolizumab for the treatment of certain cancers |
| WO2018057303A1 (en) | 2016-09-26 | 2018-03-29 | Imclone Llc | Combination therapy for cancer |
| JOP20190055A1 (ar) | 2016-09-26 | 2019-03-24 | Merck Sharp & Dohme | أجسام مضادة ضد cd27 |
| SG11201902974PA (en) | 2016-10-14 | 2019-05-30 | Merck Sharp & Dohme | Combination of a pd-1 antagonist and eribulin for treating urothelial cancer |
| EP3528834A4 (en) | 2016-10-21 | 2020-07-01 | Merck Sharp&Dohme Corp. | TREATMENT OF CANCER USING A COMBINATION OF A PD-1 ANTAGONIST AND AN IL-27 ANTAGONIST |
| RU2019122602A (ru) | 2016-12-20 | 2021-01-22 | Мерк Шарп И Доум Корп. | Комбинации антагонистов pd-1 и циклических динуклеотидных агонистов sting для лечения рака |
| US20200115451A1 (en) | 2017-03-31 | 2020-04-16 | Merck Sharp & Dohme Corp. | Compositions and methods for treating cancer with a combination of an antagonist of pd-1 and an anti-ctla4 antibody |
| TWI796329B (zh) | 2017-04-07 | 2023-03-21 | 美商默沙東有限責任公司 | 抗－ilt4抗體及抗原結合片段 |
| CA3057157A1 (en) | 2017-04-28 | 2018-11-01 | Merck Sharp & Dohme Corp. | Biomarkers for cancer therapeutics |
| JP7382232B2 (ja) | 2017-05-02 | 2023-11-16 | メルク・シャープ・アンド・ドーム・エルエルシー | 抗ｌａｇ３抗体の製剤および抗ｌａｇ３抗体と抗ｐｄ－１抗体との共製剤 |
| WO2018204343A1 (en) | 2017-05-02 | 2018-11-08 | Merck Sharp & Dohme Corp. | Stable formulations of anti-ctla4 antibodies alone and in combination with programmed death receptor 1 (pd-1) antibodies and methods of use thereof |
| MX2019013033A (es) | 2017-05-02 | 2020-02-05 | Merck Sharp & Dohme | Formulaciones estables de anticuerpos anti-tigit solos y en combinacion con anticuerpos anti-receptor de muerte programada 1 (pd-1) y metodos para su uso. |
| JOP20190260A1 (ar) | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها |
| CA3063201A1 (en) | 2017-05-09 | 2018-11-15 | Tesaro, Inc. | Combination therapies for treating cancer |
| JOP20190256A1 (ar) | 2017-05-12 | 2019-10-28 | Icahn School Med Mount Sinai | فيروسات داء نيوكاسل واستخداماتها |
| CA3063893A1 (en) | 2017-05-16 | 2018-11-22 | Immunogen, Inc. | Anti-folr1 immunoconjugates and anti-pd-1 antibody combinations |
| US11052065B2 (en) | 2017-09-27 | 2021-07-06 | Merck Sharp & Dohme Corp. | Compositions and methods for treating cancer with a combination of programmed death receptor (PD-1) antibodies and a CXCR2 antagonist |
| CA3075291A1 (en) | 2017-10-13 | 2019-04-18 | Merck Sharp & Dohme Corp. | Compositions and methods for treating diffuse large b cell lymphoma |
| JP2021501150A (ja) | 2017-10-27 | 2021-01-14 | メルク・シャープ・エンド・ドーム・コーポレイション | 肝臓がんを治療するための組成物及び方法 |
| JP7269928B2 (ja) | 2017-11-14 | 2023-05-09 | メルク・シャープ・アンド・ドーム・エルエルシー | インドールアミン ２，３－ジオキシゲナーゼ（ｉｄｏ）阻害剤としての新規の置換ビアリール化合物 |
| WO2019099597A2 (en) | 2017-11-17 | 2019-05-23 | Merck Sharp & Dohme Corp. | Antibodies specific for immunoglobulin-like transcript 3 (ilt3) and uses thereof |
| WO2019148412A1 (en) | 2018-02-01 | 2019-08-08 | Merck Sharp & Dohme Corp. | Anti-pd-1/lag3 bispecific antibodies |
| KR20200119845A (ko) | 2018-02-13 | 2020-10-20 | 머크 샤프 앤드 돔 코포레이션 | 항 pd-1 항체 및 항 ctla4 항체를 사용한 암의 치료 방법 |
| WO2019160751A2 (en) | 2018-02-13 | 2019-08-22 | Merck Sharp & Dohme Corp. | Methods for treating cancer with anti-pd-1 antibodies |
| WO2019177873A1 (en) | 2018-03-13 | 2019-09-19 | Merck Sharp & Dohme Corp. | Arginase inhibitors and methods of use |
| CN113301899A (zh) | 2018-11-16 | 2021-08-24 | 艾科尔公司 | 用于治疗癌症的药物组合 |
| TW202039496A (zh) | 2018-11-30 | 2020-11-01 | 美商默沙東藥廠 | 做為腺苷受體拮抗劑之9-經取代胺基三唑喹唑啉衍生物、醫藥組合物及其用途 |
-
2008
- 2008-06-13 SI SI200831125T patent/SI2170959T1/sl unknown
- 2008-06-13 NZ NZ600758A patent/NZ600758A/xx unknown
- 2008-06-13 EP EP16205393.8A patent/EP3222634A1/en not_active Withdrawn
- 2008-06-13 DK DK08768485.8T patent/DK2170959T3/da active
- 2008-06-13 BR BRPI0812913A patent/BRPI0812913B8/pt active IP Right Grant
- 2008-06-13 BR BR122017025062A patent/BR122017025062B8/pt active IP Right Grant
- 2008-06-13 KR KR1020157011771A patent/KR101586617B1/ko active Active
- 2008-06-13 KR KR1020147030247A patent/KR101562580B1/ko active Active
- 2008-06-13 PT PT87684858T patent/PT2170959E/pt unknown
- 2008-06-13 CA CA2855098A patent/CA2855098C/en active Active
- 2008-06-13 ES ES12170052.0T patent/ES2616355T3/es active Active
- 2008-06-13 KR KR1020107000998A patent/KR20100054780A/ko not_active Withdrawn
- 2008-06-13 EP EP08768485.8A patent/EP2170959B1/en active Active
- 2008-06-13 EP EP12170052.0A patent/EP2535354B1/en active Active
- 2008-06-13 CN CN200880103544.3A patent/CN102131828B/zh active Active
- 2008-06-13 US US12/663,950 patent/US8354509B2/en active Active
- 2008-06-13 AU AU2008266951A patent/AU2008266951C1/en active Active
- 2008-06-13 CA CA2691357A patent/CA2691357C/en active Active
- 2008-06-13 ME MEP-2013-545A patent/ME02093B/me unknown
- 2008-06-13 HR HRP20131167AT patent/HRP20131167T1/hr unknown
- 2008-06-13 NZ NZ582150A patent/NZ582150A/xx unknown
- 2008-06-13 ES ES08768485.8T patent/ES2437327T3/es active Active
- 2008-06-13 PL PL08768485T patent/PL2170959T3/pl unknown
- 2008-06-13 CN CN201510367410.4A patent/CN104945508B/zh active Active
- 2008-06-13 MX MX2009014199A patent/MX2009014199A/es active IP Right Grant
- 2008-06-13 RS RS20130545A patent/RS53072B/sr unknown
- 2008-06-13 JP JP2010513201A patent/JP5191537B2/ja active Active
- 2008-06-13 WO PCT/US2008/007463 patent/WO2008156712A1/en not_active Ceased
-
2009
- 2009-12-17 IL IL202813A patent/IL202813A/en active Protection Beyond IP Right Term
-
2010
- 2010-01-07 ZA ZA2010/00135A patent/ZA201000135B/en unknown
-
2012
- 2012-08-24 JP JP2012185573A patent/JP5640052B2/ja active Active
- 2012-12-19 US US13/719,756 patent/US8952136B2/en active Active
- 2012-12-19 US US13/719,763 patent/US8900587B2/en active Active
-
2013
- 2013-04-02 IL IL225530A patent/IL225530A0/en active IP Right Grant
- 2013-12-23 CY CY20131101161T patent/CY1114849T1/el unknown
-
2014
- 2014-12-19 US US14/576,448 patent/US9834605B2/en active Active
-
2015
- 2015-07-06 PH PH12015501524A patent/PH12015501524B1/en unknown
- 2015-12-18 HU HUS1500071C patent/HUS1500071I1/hu unknown
- 2015-12-21 NO NO2015028C patent/NO2015028I1/no not_active IP Right Cessation
- 2015-12-23 CY CY2015058C patent/CY2015058I2/el unknown
- 2015-12-28 NL NL300788C patent/NL300788I2/nl unknown
- 2015-12-29 LU LU92936C patent/LU92936I2/xx unknown
-
2016
- 2016-01-08 LT LTPA2016001C patent/LTC2170959I2/lt unknown
-
2017
- 2017-11-13 US US15/810,892 patent/US11117961B2/en active Active
-
2021
- 2021-09-08 US US17/469,359 patent/US20210403560A1/en not_active Abandoned
-
2022
- 2022-09-29 NO NO2022040C patent/NO2022040I1/no unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5191537B2 (ja) | ヒトのプログラムされたデスレセプターｐｄ−１に対する抗体 | |
| AU2014201367B2 (en) | Antibodies to human programmed death receptor pd-1 | |
| HK1236209A1 (en) | Antibodies to human programmed death receptor pd-1 | |
| HK1140497B (en) | Antibodies to human programmed death receptor pd-1 | |
| HK1179986B (en) | Antibodies to human programmed death receptor pd-1 | |
| HK1179986A (en) | Antibodies to human programmed death receptor pd-1 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20100210 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20100210 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110207 |
|
| A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A712 Effective date: 20120308 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120403 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20120529 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20120531 |
|
| RD02 | Notification of acceptance of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7422 Effective date: 20120531 |
|
| RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20120607 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120824 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20120911 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20121119 |
|
| A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20121211 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20130109 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20130129 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 5191537 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20160208 Year of fee payment: 3 |
|
| S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313111 |
|
| R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R153 | Grant of patent term extension |
Free format text: JAPANESE INTERMEDIATE CODE: R153 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R153 | Grant of patent term extension |
Free format text: JAPANESE INTERMEDIATE CODE: R153 |
|
| R153 | Grant of patent term extension |
Free format text: JAPANESE INTERMEDIATE CODE: R153 |
|
| R153 | Grant of patent term extension |
Free format text: JAPANESE INTERMEDIATE CODE: R153 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R153 | Grant of patent term extension |
Free format text: JAPANESE INTERMEDIATE CODE: R153 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R153 | Grant of patent term extension |
Free format text: JAPANESE INTERMEDIATE CODE: R153 |
|
| R153 | Grant of patent term extension |
Free format text: JAPANESE INTERMEDIATE CODE: R153 |
|
| R153 | Grant of patent term extension |
Free format text: JAPANESE INTERMEDIATE CODE: R153 |
|
| R153 | Grant of patent term extension |
Free format text: JAPANESE INTERMEDIATE CODE: R153 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R153 | Grant of patent term extension |
Free format text: JAPANESE INTERMEDIATE CODE: R153 |
|
| R153 | Grant of patent term extension |
Free format text: JAPANESE INTERMEDIATE CODE: R153 |
|
| R153 | Grant of patent term extension |
Free format text: JAPANESE INTERMEDIATE CODE: R153 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R153 | Grant of patent term extension |
Free format text: JAPANESE INTERMEDIATE CODE: R153 |
|
| R153 | Grant of patent term extension |
Free format text: JAPANESE INTERMEDIATE CODE: R153 |