BR112019017743A2 - rna terapêutico - Google Patents
rna terapêutico Download PDFInfo
- Publication number
- BR112019017743A2 BR112019017743A2 BR112019017743A BR112019017743A BR112019017743A2 BR 112019017743 A2 BR112019017743 A2 BR 112019017743A2 BR 112019017743 A BR112019017743 A BR 112019017743A BR 112019017743 A BR112019017743 A BR 112019017743A BR 112019017743 A2 BR112019017743 A2 BR 112019017743A2
- Authority
- BR
- Brazil
- Prior art keywords
- therapeutic rna
- rna
- therapeutic
- therapeutics
- treatment
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 1
- 0 CC(N)N(COC[C@](C(NC)N(*)C(*)*)N)C=C Chemical compound CC(N)N(COC[C@](C(NC)N(*)C(*)*)N)C=C 0.000 description 2
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/208—IL-12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2086—IL-13 to IL-16
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5434—IL-12
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5443—IL-15
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/335—Modified T or U
Abstract
a presente invenção refere-se ao campo de rnas terapêuticos para o tratamento de cânceres de tumor sólido.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762464981P | 2017-02-28 | 2017-02-28 | |
EP17306089 | 2017-08-23 | ||
US201762597527P | 2017-12-12 | 2017-12-12 | |
PCT/US2018/019878 WO2018160540A1 (en) | 2017-02-28 | 2018-02-27 | Therapeutic rna |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112019017743A2 true BR112019017743A2 (pt) | 2020-04-07 |
Family
ID=61569463
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112019017743A BR112019017743A2 (pt) | 2017-02-28 | 2018-02-27 | rna terapêutico |
Country Status (21)
Country | Link |
---|---|
US (2) | US20200147176A1 (pt) |
EP (1) | EP3589308A1 (pt) |
JP (3) | JP6949131B2 (pt) |
KR (1) | KR20190124750A (pt) |
CN (1) | CN110337305A (pt) |
AU (1) | AU2018229278A1 (pt) |
BR (1) | BR112019017743A2 (pt) |
CA (1) | CA3054733A1 (pt) |
CL (1) | CL2019002461A1 (pt) |
CO (1) | CO2019010355A2 (pt) |
CR (1) | CR20190444A (pt) |
EC (1) | ECSP19070336A (pt) |
IL (1) | IL268894A (pt) |
MA (1) | MA47680A (pt) |
MX (1) | MX2019010269A (pt) |
PE (1) | PE20200735A1 (pt) |
PH (1) | PH12019501959A1 (pt) |
SG (1) | SG11201907846VA (pt) |
TW (1) | TW201842921A (pt) |
UY (1) | UY37621A (pt) |
WO (1) | WO2018160540A1 (pt) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
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UY37621A (es) | 2017-02-28 | 2018-09-28 | Sanofi Sa | Arn terapéutico que codifica citoquinas |
SG11202006457YA (en) | 2018-01-05 | 2020-08-28 | Ottawa Hospital Res Inst | Modified orthopoxvirus vectors |
TW202026423A (zh) * | 2018-08-24 | 2020-07-16 | 法商賽諾菲公司 | 用於實體瘤癌症的治療性rna |
TW202043274A (zh) * | 2019-01-21 | 2020-12-01 | 法商賽諾菲公司 | 用於晚期實性瘤癌症之治療性rna及抗pd1抗體 |
WO2020154187A1 (en) * | 2019-01-21 | 2020-07-30 | Sanofi | Therapeutic rna for advanced stage solid tumor cancers |
US20210106527A1 (en) * | 2019-10-09 | 2021-04-15 | Translate Bio, Inc. | Compositions, methods and uses of messenger rna |
IL297419A (en) | 2020-04-22 | 2022-12-01 | BioNTech SE | Vaccine against the corona virus |
WO2022020811A1 (en) | 2020-07-24 | 2022-01-27 | Strand Therapeutics, Inc. | Lipidnanoparticle comprising modified nucleotides |
JP2023549592A (ja) * | 2020-10-20 | 2023-11-28 | エスティー ファーム カンパニー リミテッド | 5’-キャッピングされたrna合成用オリゴヌクレオチド |
JP2024503000A (ja) | 2021-01-08 | 2024-01-24 | ストランド セラピューティクス インコーポレイテッド | 発現構築物およびその使用 |
CA3170747A1 (en) * | 2021-01-27 | 2022-08-04 | Moritz THRAN | Method of reducing the immunostimulatory properties of in vitro transcribed rna |
WO2023056915A1 (en) * | 2021-10-08 | 2023-04-13 | Suzhou Abogen Biosciences Co., Ltd. | Polynucleotides encoding interleukin-12 (il-12) and related composition and methods thereof |
CN116179549A (zh) | 2021-12-08 | 2023-05-30 | 南京吉迈生物技术有限公司 | 通过5’utr序列变体修饰基因转录和翻译效率 |
WO2023212618A1 (en) | 2022-04-26 | 2023-11-02 | Strand Therapeutics Inc. | Lipid nanoparticles comprising venezuelan equine encephalitis (vee) replicon and uses thereof |
CN117327709A (zh) * | 2022-06-24 | 2024-01-02 | 深圳瑞吉生物科技有限公司 | 用于实体肿瘤的治疗性mRNA及其应用 |
WO2024002985A1 (en) | 2022-06-26 | 2024-01-04 | BioNTech SE | Coronavirus vaccine |
WO2024026490A1 (en) | 2022-07-28 | 2024-02-01 | Sqz Biotechnologies Company | Polynucleotides encoding linked antigens and uses thereof |
WO2024074634A1 (en) * | 2022-10-06 | 2024-04-11 | BioNTech SE | Rna compositions targeting claudin-18.2 |
WO2024074211A1 (en) * | 2022-10-06 | 2024-04-11 | BioNTech SE | Rna compositions targeting claudin-18.2 |
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2018
- 2018-02-27 UY UY0001037621A patent/UY37621A/es not_active Application Discontinuation
- 2018-02-27 BR BR112019017743A patent/BR112019017743A2/pt not_active IP Right Cessation
- 2018-02-27 SG SG11201907846VA patent/SG11201907846VA/en unknown
- 2018-02-27 CR CR20190444A patent/CR20190444A/es unknown
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- 2018-02-27 TW TW107106479A patent/TW201842921A/zh unknown
- 2018-02-27 MA MA047680A patent/MA47680A/fr unknown
- 2018-02-27 CA CA3054733A patent/CA3054733A1/en active Pending
- 2018-02-27 KR KR1020197028213A patent/KR20190124750A/ko not_active Application Discontinuation
- 2018-02-27 AU AU2018229278A patent/AU2018229278A1/en not_active Abandoned
- 2018-02-27 WO PCT/US2018/019878 patent/WO2018160540A1/en unknown
- 2018-02-27 JP JP2019546924A patent/JP6949131B2/ja active Active
- 2018-02-27 PE PE2019001764A patent/PE20200735A1/es unknown
- 2018-02-27 EP EP18709243.2A patent/EP3589308A1/en active Pending
- 2018-02-27 CN CN201880013857.3A patent/CN110337305A/zh active Pending
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2019
- 2019-08-25 IL IL26889419A patent/IL268894A/en unknown
- 2019-08-26 CL CL2019002461A patent/CL2019002461A1/es unknown
- 2019-08-27 US US16/552,248 patent/US20200147176A1/en not_active Abandoned
- 2019-08-27 PH PH12019501959A patent/PH12019501959A1/en unknown
- 2019-09-25 CO CONC2019/0010355A patent/CO2019010355A2/es unknown
- 2019-09-27 EC ECSENADI201970336A patent/ECSP19070336A/es unknown
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2021
- 2021-03-10 JP JP2021037923A patent/JP7201725B2/ja active Active
- 2021-04-30 US US17/245,605 patent/US11865159B2/en active Active
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2022
- 2022-12-21 JP JP2022203863A patent/JP7461449B2/ja active Active
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US20210290730A1 (en) | 2021-09-23 |
JP6949131B2 (ja) | 2021-10-13 |
US11865159B2 (en) | 2024-01-09 |
CL2019002461A1 (es) | 2020-01-17 |
US20200147176A1 (en) | 2020-05-14 |
CO2019010355A2 (es) | 2019-10-09 |
WO2018160540A1 (en) | 2018-09-07 |
PH12019501959A1 (en) | 2020-07-06 |
SG11201907846VA (en) | 2019-09-27 |
JP2020509016A (ja) | 2020-03-26 |
KR20190124750A (ko) | 2019-11-05 |
IL268894A (en) | 2019-10-31 |
ECSP19070336A (es) | 2019-10-31 |
CN110337305A (zh) | 2019-10-15 |
EP3589308A1 (en) | 2020-01-08 |
CA3054733A1 (en) | 2018-09-07 |
TW201842921A (zh) | 2018-12-16 |
MA47680A (fr) | 2020-01-08 |
JP7461449B2 (ja) | 2024-04-03 |
MX2019010269A (es) | 2019-10-14 |
UY37621A (es) | 2018-09-28 |
JP2023030083A (ja) | 2023-03-07 |
JP2021098735A (ja) | 2021-07-01 |
PE20200735A1 (es) | 2020-07-23 |
CR20190444A (es) | 2019-12-17 |
JP7201725B2 (ja) | 2023-01-10 |
AU2018229278A1 (en) | 2019-10-17 |
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