SG11201707832RA - Rna containing composition for treatment of tumor diseases - Google Patents

Rna containing composition for treatment of tumor diseases

Info

Publication number
SG11201707832RA
SG11201707832RA SG11201707832RA SG11201707832RA SG11201707832RA SG 11201707832R A SG11201707832R A SG 11201707832RA SG 11201707832R A SG11201707832R A SG 11201707832RA SG 11201707832R A SG11201707832R A SG 11201707832RA SG 11201707832R A SG11201707832R A SG 11201707832RA
Authority
SG
Singapore
Prior art keywords
treatment
containing composition
tumor diseases
rna containing
rna
Prior art date
Application number
SG11201707832RA
Inventor
Mariola Fotin-Mleczek
Aleksandra Kowalczyk
Regina Heidenreich
Patrick Baumhof
Jochen Probst
Karl-Josef Kallen
Original Assignee
Curevac Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53005455&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201707832R(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Curevac Ag filed Critical Curevac Ag
Publication of SG11201707832RA publication Critical patent/SG11201707832RA/en

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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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Families Citing this family (165)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012113413A1 (en) * 2011-02-21 2012-08-30 Curevac Gmbh Vaccine composition comprising complexed immunostimulatory nucleic acids and antigens packaged with disulfide-linked polyethyleneglycol/peptide conjugates
WO2013120497A1 (en) 2012-02-15 2013-08-22 Curevac Gmbh Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded therapeutic protein
DK2857420T3 (en) 2012-05-30 2020-11-23 Chugai Pharmaceutical Co Ltd TARGET TISSUE SPECIFIC ANTIGIN BINDING MOLECULE
JP6144355B2 (en) 2012-11-26 2017-06-07 モデルナティエックス インコーポレイテッドＭｏｄｅｒｎａＴＸ，Ｉｎｃ． Chemically modified mRNA
CA2897941A1 (en) 2013-01-17 2014-07-24 Moderna Therapeutics, Inc. Signal-sensor polynucleotides for the alteration of cellular phenotypes
CN109045289A (en) 2013-02-22 2018-12-21 库瑞瓦格股份公司 Vaccine inoculation and the combination for inhibiting PD-1 approach
US11267868B2 (en) 2013-04-02 2022-03-08 Chugai Seiyaku Kabushiki Kaisha Fc region variant
JP6896421B2 (en) 2013-08-21 2021-06-30 キュアバック アーゲー Respiratory syncytial virus (RSV) vaccine
CA2915712A1 (en) 2013-08-21 2015-02-26 Margit SCHNEE Rabies vaccine
EP3052106A4 (en) 2013-09-30 2017-07-19 ModernaTX, Inc. Polynucleotides encoding immune modulating polypeptides
ES2806575T3 (en) 2013-11-01 2021-02-18 Curevac Ag Modified RNA with decreased immunostimulatory properties
SG11201604495PA (en) 2013-12-04 2016-07-28 Chugai Pharmaceutical Co Ltd Antigen-binding molecules, the antigen-binding activity of which varies according to the concentration of compounds, and libraries of said molecules
AU2014375404C1 (en) 2013-12-30 2020-11-19 CureVac Manufacturing GmbH Methods for RNA analysis
WO2015101415A1 (en) 2013-12-30 2015-07-09 Curevac Gmbh Artificial nucleic acid molecules
CA2936286A1 (en) 2014-04-01 2015-10-08 Curevac Ag Polymeric carrier cargo complex for use as an immunostimulating agent or as an adjuvant
CA2946751A1 (en) 2014-04-23 2015-10-29 Modernatx, Inc. Nucleic acid vaccines
MX2016016170A (en) 2014-06-10 2017-03-28 Curevac Ag Methods and means for enhancing rna production.
DE202015010000U1 (en) 2014-12-12 2023-07-03 CureVac SE Artificial nucleic acid molecules for improved protein expression
WO2016165825A1 (en) 2015-04-13 2016-10-20 Curevac Ag Method for producing rna compositions
WO2016165831A1 (en) 2015-04-17 2016-10-20 Curevac Ag Lyophilization of rna
JP6912384B2 (en) 2015-04-22 2021-08-04 キュアバック アーゲー RNA-containing compositions for the treatment of cancer diseases
SG11201708867UA (en) 2015-04-30 2017-11-29 Curevac Ag Immobilized poly(n)polymerase
EP3294885B1 (en) 2015-05-08 2020-07-01 CureVac Real Estate GmbH Method for producing rna
US11559570B2 (en) 2015-05-15 2023-01-24 CureVac SE Prime-boost regimens involving administration of at least one mRNA construct
WO2016184575A1 (en) 2015-05-20 2016-11-24 Curevac Ag Dry powder composition comprising long-chain rna
EP3297682B1 (en) 2015-05-20 2021-07-14 CureVac AG Dry powder composition comprising long-chain rna
EP3744843A1 (en) 2015-05-29 2020-12-02 CureVac Real Estate GmbH A method for producing and purifying rna, comprising at least one step of tangential flow filtration
EP4098743A1 (en) 2015-05-29 2022-12-07 CureVac AG Method for adding cap structures to rna using immobilized enzymes
US10501768B2 (en) 2015-07-13 2019-12-10 Curevac Ag Method of producing RNA from circular DNA and corresponding template DNA
ES2937963T3 (en) 2015-07-21 2023-04-03 Modernatx Inc Infectious disease vaccines
US11364292B2 (en) 2015-07-21 2022-06-21 Modernatx, Inc. CHIKV RNA vaccines
WO2017062513A1 (en) 2015-10-05 2017-04-13 Modernatx, Inc. Methods for therapeutic administration of messenger ribonucleic acid drugs
EP3362576A1 (en) 2015-10-12 2018-08-22 CureVac AG Automated method for isolation, selection and/or detection of microorganisms or cells comprised in a solution
WO2017070624A1 (en) 2015-10-22 2017-04-27 Modernatx, Inc. Tropical disease vaccines
CA3002819A1 (en) * 2015-10-22 2017-04-27 Modernatx, Inc. Sexually transmitted disease vaccines
WO2017081110A1 (en) 2015-11-09 2017-05-18 Curevac Ag Rotavirus vaccines
EP3701963A1 (en) 2015-12-22 2020-09-02 CureVac AG Method for producing rna molecule compositions
WO2017109161A1 (en) 2015-12-23 2017-06-29 Curevac Ag Method of rna in vitro transcription using a buffer containing a dicarboxylic acid or tricarboxylic acid or a salt thereof
DK3394093T3 (en) 2015-12-23 2022-04-19 Modernatx Inc PROCEDURES FOR USING OX40 LIGAND CODING POLYNUCLEOTIDES
SG11201806340YA (en) 2016-02-17 2018-09-27 Curevac Ag Zika virus vaccine
US11920174B2 (en) 2016-03-03 2024-03-05 CureVac SE RNA analysis by total hydrolysis and quantification of released nucleosides
EP3445392A1 (en) * 2016-04-22 2019-02-27 CureVac AG Rna encoding a tumor antigen
EP3448427A1 (en) 2016-04-29 2019-03-06 CureVac AG Rna encoding an antibody
WO2017191264A1 (en) 2016-05-04 2017-11-09 Curevac Ag Nucleic acid molecules and uses thereof
EP3452101A2 (en) 2016-05-04 2019-03-13 CureVac AG Rna encoding a therapeutic protein
MA45037A (en) 2016-05-18 2019-03-27 Modernatx Inc RNAM-BASED POLYTHERAPY FOR CANCER TREATMENT
KR102469450B1 (en) * 2016-05-18 2022-11-22 모더나티엑스, 인크. Polynucleotides Encoding Interleukin-12 (IL12) and Uses Thereof
EP4137509A1 (en) 2016-05-18 2023-02-22 ModernaTX, Inc. Combinations of mrnas encoding immune modulating polypeptides and uses thereof
WO2017212009A1 (en) 2016-06-09 2017-12-14 Curevac Ag Hybrid carriers for nucleic acid cargo
SG10201913631TA (en) * 2016-08-19 2020-03-30 Curevac Ag Rna for cancer therapy
BR112019008369A2 (en) * 2016-10-26 2019-10-01 Modernatx Inc messenger ribonucleic acids to enhance immune responses and methods for using them
US11279923B2 (en) 2016-11-28 2022-03-22 Curevac Ag Method for purifying RNA
WO2018104540A1 (en) 2016-12-08 2018-06-14 Curevac Ag Rnas for wound healing
CN110582304A (en) 2016-12-08 2019-12-17 库尔维科公司 RNA for treating or preventing liver disease
MX2019006852A (en) * 2016-12-22 2019-08-26 Windmil Therapeutics Inc Compositions and methods for modulating the immune system.
WO2018115525A1 (en) 2016-12-23 2018-06-28 Curevac Ag Lassa virus vaccine
WO2018115527A2 (en) 2016-12-23 2018-06-28 Curevac Ag Mers coronavirus vaccine
WO2018115507A2 (en) 2016-12-23 2018-06-28 Curevac Ag Henipavirus vaccine
KR20190120233A (en) * 2017-02-01 2019-10-23 모더나티엑스, 인크. RNA cancer vaccine
KR20190110612A (en) 2017-02-01 2019-09-30 모더나티엑스, 인크. Immunomodulatory Therapeutic MRNA Compositions Encoding Activating Oncogene Mutant Peptides
WO2018152371A1 (en) * 2017-02-15 2018-08-23 Fred Hutchinson Cancer Research Center In vivo gene therapy for immune deficiencies
AU2018222735B2 (en) 2017-02-17 2023-04-27 George Todaro Use of TGF alpha for the treatment of diseases and disorders
WO2018156180A1 (en) 2017-02-24 2018-08-30 Kindred Biosciences, Inc. Anti-il31 antibodies for veterinary use
UY37621A (en) * 2017-02-28 2018-09-28 Sanofi Sa THERAPEUTIC ARN THAT CODIFIES CYTOKINS
WO2018170288A1 (en) 2017-03-15 2018-09-20 Pandion Therapeutics, Inc. Targeted immunotolerance
JP2020513824A (en) 2017-03-24 2020-05-21 キュアバック アーゲー NUCLEIC ACID ENCODING CRISPR-RELATED PROTEIN AND USE THEREOF
US11357856B2 (en) 2017-04-13 2022-06-14 Acuitas Therapeutics, Inc. Lipids for delivery of active agents
WO2018213731A1 (en) 2017-05-18 2018-11-22 Modernatx, Inc. Polynucleotides encoding tethered interleukin-12 (il12) polypeptides and uses thereof
BR112019024127A2 (en) 2017-05-24 2020-06-23 Pandion Therapeutics, Inc. TARGETED IMMUNOTOLERANCE
US11945851B2 (en) 2017-06-07 2024-04-02 The Wistar Institute Of Anatomy And Biology MAGE-A vaccines and methods of treatment using the same
BR112019028280A2 (en) 2017-07-04 2020-07-14 Curevac Ag nucleic acid molecules
EP3673069A1 (en) 2017-08-22 2020-07-01 CureVac AG Bunyavirales vaccine
CA3074288A1 (en) * 2017-09-06 2019-03-14 Airway Therapeutics, LLC Methods, compositions and cells for preparing surfactant protein d (sp-d)
AU2018328112B2 (en) 2017-09-06 2023-08-24 Airway Therapeutics, Inc. Methods and compositions for preparing surfactant protein D (SP-D)
MX2020003995A (en) 2017-10-19 2020-07-22 Curevac Ag Novel artificial nucleic acid molecules.
US11692002B2 (en) 2017-11-08 2023-07-04 CureVac SE RNA sequence adaptation
JP2021502828A (en) * 2017-11-14 2021-02-04 メモリアル スローン ケタリング キャンサー センター Immune-responsive cells secreting IL-33 and their use
WO2019100016A1 (en) * 2017-11-17 2019-05-23 Abbvie Inc. Methods of treating glioblastoma
US10946068B2 (en) 2017-12-06 2021-03-16 Pandion Operations, Inc. IL-2 muteins and uses thereof
US10174091B1 (en) 2017-12-06 2019-01-08 Pandion Therapeutics, Inc. IL-2 muteins
US11931406B2 (en) 2017-12-13 2024-03-19 CureVac SE Flavivirus vaccine
BR112020011820A2 (en) * 2017-12-13 2020-11-17 Inovio Pharmaceuticals, Inc. nucleic acid molecules and their uses, vector, compositions, proteins and vaccines
SG11202005760PA (en) 2017-12-21 2020-07-29 Curevac Ag Linear double stranded dna coupled to a single support or a tag and methods for producing said linear double stranded dna
CN108126185A (en) * 2017-12-26 2018-06-08 南昌大学 The negative regulatory factor targeted silent of DC mobilizes the tumour conjoint therapy of amplification with DC
US11857585B2 (en) 2017-12-28 2024-01-02 Bionoxx Inc. Oncolytic virus improved in safety and anticancer effect
US20210069310A1 (en) * 2018-01-05 2021-03-11 Rolf Jonas Andreas NILSSON Endogenous tumor-derived circular rna and proteins thereof for use as vaccine
AU2019205904A1 (en) 2018-01-05 2020-06-18 Dicerna Pharmaceuticals, Inc. Reducing beta-catenin and IDO expression to potentiate immunotherapy
CN110016464A (en) * 2018-01-08 2019-07-16 张晋宇 For screening the system and method for antitumorigenic substance
EP3768698A4 (en) * 2018-03-19 2022-03-30 MultiVir Inc. Methods and compositions comprising tumor suppressor gene therapy and cd122/cd132 agonists for the treatment of cancer
JP2021524756A (en) * 2018-05-14 2021-09-16 ウェアウルフ セラピューティクス， インコーポレイテッド Activateable cytokine polypeptides and how to use them
GB201807831D0 (en) * 2018-05-15 2018-06-27 Univ College Cardiff Consultants Ltd Cancer Vaccine
EP3794010A4 (en) * 2018-05-17 2022-03-23 The Regents of The University of California Methods of modulating activity of a cyclic dinucleotide (cdn) with a cdn transporter-modulating agent
KR102536314B1 (en) * 2018-05-23 2023-05-25 주식회사 휴벳바이오 Composition for diagnosing disease
CN112399860A (en) * 2018-06-06 2021-02-23 麻省理工学院 Circular RNA for translation in eukaryotic cells
EP3810641A4 (en) * 2018-06-19 2022-07-13 H. Lee Moffitt Cancer Center And Research Institute, Inc. Oncolytic virus or antigen presenting cell mediated cancer therapy using type i interferon and cd40-ligand
WO2020028656A1 (en) 2018-08-01 2020-02-06 Nantkwest, Inc. A quadricistronic system comprising a homing receptor or a cytokine, and chimeric antigen receptor for genetic modification of immunotherapies
WO2020032230A1 (en) * 2018-08-10 2020-02-13 中外製薬株式会社 Anti-cd137 antigen-binding molecule and utilization thereof
JP2022520138A (en) 2018-08-28 2022-03-29 ブイオーアール バイオファーマ インコーポレーテッド Genetically engineered hematopoietic stem cells and their use
US20230081530A1 (en) * 2018-09-14 2023-03-16 Modernatx, Inc. Methods and compositions for treating cancer using mrna therapeutics
WO2020068541A1 (en) * 2018-09-25 2020-04-02 Siemens Healthcare Diagnostics Inc. Methods and compositions for removing biotin interference from assays using molecular traps
CN112703400A (en) * 2018-09-25 2021-04-23 美国西门子医学诊断股份有限公司 Methods and compositions for removing biotin interference from assays using cyclodextrin traps
CN111110847A (en) * 2018-11-01 2020-05-08 香港城市大学深圳研究院 Method for inhibiting enterovirus A71 infection by targeted Hsp27 and related application
CN109355373B (en) * 2018-11-29 2021-06-29 复旦大学附属眼耳鼻喉科医院 Application of circRNA in preparation of proliferative vitreoretinopathy diagnostic reagent
US20200172865A1 (en) * 2018-12-04 2020-06-04 Innovative Cellular Therapeutics CO., LTD. Modified Cell with Enhanced Migration Capability
GB201821089D0 (en) * 2018-12-21 2019-02-06 Gyroscope Therapeutics Ltd Codon-optimised complement factor I
JP2022516252A (en) * 2018-12-21 2022-02-25 シーエー＊ティーエックス， インコーポレイテッド Pharmaceutical combination for treating cancer
US11098093B2 (en) 2019-01-07 2021-08-24 Shattuck Labs, Inc. Heterodimeric proteins for modulating gamma delta T cells
EP3902557A4 (en) 2019-01-07 2023-06-07 Shattuck Labs, Inc. Heterodimeric proteins for modulating gamma delta t cells
TW202043256A (en) 2019-01-10 2020-12-01 美商健生生物科技公司 Prostate neoantigens and their uses
MX2021008490A (en) * 2019-01-16 2021-09-28 Univ Columbia Compositions and methods for inhibition of lineage specific antigens.
CN113507964A (en) * 2019-03-06 2021-10-15 马里兰大学，巴尔的摩 Tetrameric protein scaffolds as nanocarriers of therapeutic peptides for the treatment of cancer and other diseases
US20220211845A1 (en) * 2019-05-08 2022-07-07 The Wistar Institute Of Anatomy And Biology Dna encoded il-36 gamma as an adjuvant
US20220241359A1 (en) * 2019-05-15 2022-08-04 Codagenix Inc. Attenuated yellow fever virus and uses thereof for the treatment of cancer
KR20220035333A (en) 2019-05-20 2022-03-22 팬디온 오퍼레이션스, 인코포레이티드 MADCAM Targeted Immune Tolerance
WO2020257401A1 (en) * 2019-06-21 2020-12-24 The Children's Medical Center Corporation Methods and compositions for the treatment of cancer
US20220249389A1 (en) * 2019-07-12 2022-08-11 Oregon Health & Science University Immunotherapeutic constructs and methods of their use
US11795210B2 (en) 2019-07-16 2023-10-24 Gilead Sciences, Inc. HIV vaccines and methods of making and using
US20220307017A1 (en) * 2019-08-29 2022-09-29 Universität Zürich Minimal Messenger RNAs and uses thereof
JP2022552286A (en) * 2019-10-09 2022-12-15 トランスレイト バイオ， インコーポレイテッド Compositions, methods and uses of messenger RNA
CA3157859A1 (en) * 2019-10-15 2021-04-22 Modernatx, Inc. Mrnas encoding immune modulating polypeptides and uses thereof
US11879000B2 (en) 2019-11-15 2024-01-23 National Guard Health Affairs Purification and identification of a protein complex containing b-cell lymphoma protein (BCL10)
IL293482A (en) * 2019-12-02 2022-08-01 Astellas Pharma Inc Ny-eso-1-containing artificial adjuvant vector containing cells, compositions containing same and uses use thereof in the treatment of cancer
CN114901360A (en) 2019-12-20 2022-08-12 库瑞瓦格股份公司 Novel lipid nanoparticles for delivery of nucleic acids
US11230699B2 (en) 2020-01-28 2022-01-25 Immunitybio, Inc. Chimeric antigen receptor-modified NK-92 cells targeting EGFR super-family receptors
US11241493B2 (en) 2020-02-04 2022-02-08 Curevac Ag Coronavirus vaccine
US11576966B2 (en) 2020-02-04 2023-02-14 CureVac SE Coronavirus vaccine
WO2021183218A1 (en) * 2020-03-13 2021-09-16 Dana-Farber Cancer Institute, Inc. Compositions and methods for modulating the interaction between ss18-ssx fusion oncoprotein and nucleosomes
CA3172489A1 (en) 2020-03-23 2021-09-30 Amit KHANDHAR Nanoemulsion compositions and methods for delivery of nra
KR102608311B1 (en) * 2020-04-17 2023-12-01 광주과학기술원 CRBN binding peptide and composition for preventing or treating Alzheimer's disease using the same
US11091524B1 (en) 2020-04-22 2021-08-17 Houston Gene Therapeutics Llc Compositions for treatment of vascular disease
WO2021225820A1 (en) * 2020-05-06 2021-11-11 Navicure Biopharmaceuticals Limited Fusion proteins for immunotherapy against cancer and infectious diseases
CN111849910B (en) * 2020-05-27 2021-06-15 南京北恒生物科技有限公司 Engineered immune cells and uses thereof
CN111840324B (en) * 2020-06-16 2023-05-12 上海市第一人民医院 Au DENPs-macrophage complex applied to osteosarcoma cell imaging or treatment
CN112089835B (en) * 2020-09-17 2021-10-22 澳门科技大学 Pharmaceutical composition comprising a non-coding RNA molecule and an antibody targeting a tumor antigen
JP2023548498A (en) * 2020-11-04 2023-11-17 エスリス ゲーエムベーハー Use of IFN-lambda mRNA to treat viral infections
CN112438988B (en) * 2020-11-23 2021-12-07 烟台大学 Charge reversal type core/shell drug carrier based on self-assembly, preparation method and application thereof
CN112501140B (en) * 2020-12-16 2022-03-18 熊猫乳品集团股份有限公司 Bioactive polypeptide YFGSGFAAPFFIVRHQLLKK, and preparation method and application thereof
AU2021405281A1 (en) 2020-12-22 2023-07-06 CureVac SE Rna vaccine against sars-cov-2 variants
JP2024503000A (en) * 2021-01-08 2024-01-24 ストランド セラピューティクス インコーポレイテッド Expression constructs and their use
WO2022165027A2 (en) * 2021-01-27 2022-08-04 Spark Therapeutics, Inc. Compositions and methods for treating hereditary angioedema
CN112957472B (en) * 2021-02-05 2021-11-16 无锡市第五人民医院 Hepatitis B immunotherapeutic agent targeting CCL19/CCR7 and use thereof
EP4298230A1 (en) * 2021-02-25 2024-01-03 Lyell Immunopharma, Inc. Codon-optimized nucleotide sequences encoding an ap-1 transcription factor
US20220339245A1 (en) * 2021-04-27 2022-10-27 Academia Sinica Methods of treating hypertriglyceridemia or hypertriglyceridemia-related diseases
CN113308543B (en) * 2021-05-28 2022-03-08 青岛市妇女儿童医院 Application of hsa _ circ _0000284 in preparation of neuroblastoma prognosis preparation
CN113621690B (en) * 2021-07-26 2023-08-22 山西医科大学 Application of interleukin 32 as target in screening and targeting medicine for treating esophageal squamous carcinoma
IL309502A (en) 2021-09-03 2024-02-01 CureVac SE Novel lipid nanoparticles for delivery of nucleic acids comprising phosphatidylserine
IL309505A (en) 2021-09-03 2024-02-01 CureVac SE Novel lipid nanoparticles for delivery of nucleic acids
WO2023034920A2 (en) * 2021-09-03 2023-03-09 Singular Genomics Systems, Inc. Amplification oligonucleotides
CA3232725A1 (en) * 2021-09-22 2023-03-30 Steven Gregory REED Cancer therapy compositions and uses thereof
WO2023060126A1 (en) * 2021-10-06 2023-04-13 Dana-Farber Cancer Institute, Inc. Engineered cytokine receptors for tunable adoptive cell therapy
WO2023107574A2 (en) * 2021-12-07 2023-06-15 The Brigham And Women’S Hospital, Inc. Lipid-based compositions and methods thereof
CN114349950A (en) * 2021-12-15 2022-04-15 深圳先进技术研究院 Antibody synthetic bacterium-nano stimulant hybrid system and application thereof
WO2023161350A1 (en) * 2022-02-24 2023-08-31 Io Biotech Aps Nucleotide delivery of cancer therapy
WO2023172948A1 (en) * 2022-03-08 2023-09-14 Ohio State Innovation Foundation Ccl5 mrna nanoparticle and methods of use thereof
WO2023201199A2 (en) * 2022-04-11 2023-10-19 The Johns Hopkins University Tuberculosis vaccines
WO2023212654A2 (en) * 2022-04-27 2023-11-02 The Regents Of The University Of Colorado A Body Corporate Non-endogenous protein production in plant systems
CN114832114B (en) * 2022-05-06 2024-01-30 黑龙江中医药大学 ATRA-PBAE prodrug copolymer, and preparation method and application thereof
WO2023220746A1 (en) * 2022-05-13 2023-11-16 Corner Therapeutics, Inc. Mrna encoding a constitutively-active cyclic gmp-amp synthase and lipid delivery vehicles for same
WO2023220747A1 (en) * 2022-05-13 2023-11-16 Corner Therapeutics, Inc. Nucleic acids encoding a constitutively-active cyclic gmp-amp synthase and immunogenic delivery vehicles for same
CN117327709A (en) * 2022-06-24 2024-01-02 深圳瑞吉生物科技有限公司 Therapeutic mRNA for solid tumors and uses thereof
CN115125203B (en) * 2022-07-08 2023-10-27 珠海贝索细胞科学技术有限公司 Th2 cell in-vitro culture method
WO2024015741A1 (en) 2022-07-12 2024-01-18 Gilead Sciences, Inc. Hiv immunogenic polypeptides and vaccines and uses thereof
CN115400141B (en) * 2022-09-20 2023-08-11 天津医科大学总医院 Application of STING agonist in preparation of medicine for treating chronic pruritus
CN115569198B (en) * 2022-12-07 2023-03-10 中国人民解放军军事科学院军事医学研究院 Use of EFTUD2 inhibitors for treating medulloblastoma
CN116983394B (en) * 2023-06-26 2024-02-13 山东元辰生物医药科技集团有限公司 mRNA vaccine and application thereof in intratumoral delivery for enhancing tumor treatment effect

Family Cites Families (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5821332A (en) 1993-11-03 1998-10-13 The Board Of Trustees Of The Leland Stanford Junior University Receptor on the surface of activated CD4+ T-cells: ACT-4
US5759546A (en) 1994-02-04 1998-06-02 Weinberg; Andrew D. Treatment of CD4 T-cell mediated conditions
US6242566B1 (en) 1994-02-10 2001-06-05 Board Of Trustees Of The Leland Stanford Junior University Ligand (ACT-4-L) to a receptor on the surface of activated CD4+ T-cells
US5786464C1 (en) 1994-09-19 2012-04-24 Gen Hospital Corp Overexpression of mammalian and viral proteins
US6114148C1 (en) 1996-09-20 2012-05-01 Gen Hospital Corp High level expression of proteins
EP1619254B1 (en) 1999-09-09 2010-12-22 CureVac GmbH Transfer of mRNA using polycationic compounds
WO2002064799A2 (en) 1999-09-28 2002-08-22 Transkaryotic Therapies, Inc. Optimized messenger rna
DE60113805T2 (en) * 2000-01-20 2006-07-13 Universität Zürich Institut für Medizinische Virologie Intratumoral administration of naked IL-12-encoding nucleic acid molecules
ES2164011B1 (en) * 2000-02-25 2003-05-16 Inst Cientifico Tecnol Navarra COMBINED USE OF IP-10 CHEMIOKIN AND INTERLEUCINE-12 IN THE PREPARATION OF COMPOSITIONS FOR THE TREATMENT OF EVIL TUMORS.
CN1318644A (en) * 2000-04-18 2001-10-24 西安医科大学 Construction process of recombined human single-chain interleukin-12
WO2002060485A2 (en) 2001-01-31 2002-08-08 Idec Pharmaceuticals Corporation Use of immunoregulatory antibodies in the treatment of neoplastic disorders
ES2340532T3 (en) 2001-06-05 2010-06-04 Curevac Gmbh MRNA WITH AN INCREASED G / C CONTENT THAT CODIFIES FOR A BACTERIAL ANTIGEN AND USING THE SAME.
TW200303759A (en) 2001-11-27 2003-09-16 Schering Corp Methods for treating cancer
DE10162480A1 (en) 2001-12-19 2003-08-07 Ingmar Hoerr The application of mRNA for use as a therapeutic agent against tumor diseases
AU2003235707A1 (en) 2002-01-18 2003-07-30 Curevac Gmbh Immunogenic preparations and vaccines on the basis of mrna
US7074596B2 (en) 2002-03-25 2006-07-11 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Synthesis and use of anti-reverse mRNA cap analogues
EP3006043B1 (en) 2002-04-04 2019-05-29 Zoetis Belgium S.A. Immunostimulatory g,u-containing oligoribonucleotides
DE10229872A1 (en) 2002-07-03 2004-01-29 Curevac Gmbh Immune stimulation through chemically modified RNA
DE10248141B4 (en) 2002-10-11 2007-04-19 Universitätsklinikum Hamburg-Eppendorf Nucleic acids and their use for gene therapy
CN1784421A (en) * 2003-05-09 2006-06-07 法默卡有限公司 Immunogenic human TNF alpha analogues with reduced cytotoxicity and methods of their preparation
US20120045423A1 (en) 2010-08-20 2012-02-23 Immunovative Therapies Ltd. Cells expressing TH1 characteristics and cytolytic properties
DE10335833A1 (en) 2003-08-05 2005-03-03 Curevac Gmbh Transfection of blood cells with mRNA for immune stimulation and gene therapy
US20050181035A1 (en) 2004-02-17 2005-08-18 Dow Steven W. Systemic immune activation method using non CpG nucleic acids
AU2005243250A1 (en) * 2004-04-02 2005-11-24 Coley Pharmaceutical Gmbh Immunostimulatory nucleic acids for inducing IL-10 responses
DE102004035227A1 (en) 2004-07-21 2006-02-16 Curevac Gmbh mRNA mixture for vaccination against tumor diseases
DE102004042546A1 (en) * 2004-09-02 2006-03-09 Curevac Gmbh Combination therapy for immune stimulation
US7964571B2 (en) 2004-12-09 2011-06-21 Egen, Inc. Combination of immuno gene therapy and chemotherapy for treatment of cancer and hyperproliferative diseases
DE102005023170A1 (en) 2005-05-19 2006-11-23 Curevac Gmbh Optimized formulation for mRNA
WO2007031322A1 (en) 2005-09-14 2007-03-22 Gunther Hartmann Compositions comprising immunostimulatory rna oligonucleotides and methods for producing said rna oligonucleotides
CN101394865B (en) 2005-12-01 2013-02-13 都柏林伊丽莎白女皇神学院院长、研究员及专家协会 Compositions and methods relating to treatment of cancer and infectious diseases
WO2007084364A2 (en) 2006-01-13 2007-07-26 The Government Of The United States, As Represented By The Secretary Of Health And Human Services, National Institutes Of Health Improved il-12 for expression in mammalian cells
KR100788930B1 (en) 2006-04-18 2007-12-27 포항공과대학교 산학협력단 Anti-Cancer Compositions
JP2009544754A (en) 2006-07-28 2009-12-17 アプライド バイオシステムズ， エルエルシー Dinucleotide MRNA cap analog
DE102006035618A1 (en) 2006-07-31 2008-02-07 Curevac Gmbh New nucleic acid useful as immuno-stimulating adjuvant for manufacture of a composition for treatment of cancer diseases e.g. colon carcinomas and infectious diseases e.g. influenza and malaria
DE102006061015A1 (en) 2006-12-22 2008-06-26 Curevac Gmbh Process for the purification of RNA on a preparative scale by HPLC
DE102007001370A1 (en) 2007-01-09 2008-07-10 Curevac Gmbh RNA-encoded antibodies
ES2500515T3 (en) 2007-06-19 2014-09-30 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Synthesis and use of anti-reverse phosphorothioate analogues of the messenger RNA cap
WO2009030254A1 (en) 2007-09-04 2009-03-12 Curevac Gmbh Complexes of rna and cationic peptides for transfection and for immunostimulation
PT2201100E (en) * 2007-09-14 2016-06-03 Univ Brussel Vrije Enhancing the t-cells stimulatory capacity of human antigen presenting cells and their use in vaccination
US20130108663A1 (en) 2007-09-14 2013-05-02 Vrije Universiteit Brussel Enhancing the t-cell stimulatory capacity of human antigen presenting cells in vitro and in vivo and their use in vaccination
WO2009046738A1 (en) 2007-10-09 2009-04-16 Curevac Gmbh Composition for treating lung cancer, particularly of non-small lung cancers (nsclc)
WO2009046739A1 (en) * 2007-10-09 2009-04-16 Curevac Gmbh Composition for treating prostate cancer (pca)
CA2710534C (en) 2008-01-31 2018-09-04 Curevac Gmbh Nucleic acids of formula (i) (nuglxmgnnv)a and derivatives thereof as an immunostimulating agent/adjuvant
US8206925B2 (en) * 2008-04-14 2012-06-26 Medical Diagnostic Laboratories, Llc Splice variants of human IL-23 receptor (IL-23R) mRNA and use of a delta 9 isoform in predicting inflammatory bowel diseases
WO2009140206A1 (en) 2008-05-11 2009-11-19 The Gov. Of The U. S. A., As Represented By The Secretary Of The Dept. Of Health And Human Services Improved expression of il-12 family heterodimers
PL215513B1 (en) 2008-06-06 2013-12-31 Univ Warszawski New borane phosphate analogs of dinucleotides, their application, RNA particle, method of obtaining RNA and method of obtaining peptides or protein
WO2009149539A1 (en) * 2008-06-10 2009-12-17 Université de Montréal Enhancing antigen-specific cd8+ t cell response using irf-7 mrna
WO2010037408A1 (en) 2008-09-30 2010-04-08 Curevac Gmbh Composition comprising a complexed (m)rna and a naked mrna for providing or enhancing an immunostimulatory response in a mammal and uses thereof
CA2739902A1 (en) * 2008-10-08 2010-04-15 Intrexon Corporation Engineered cells expressing multiple immunomodulators and uses thereof
ES2368963B1 (en) 2009-07-04 2012-10-10 Fundación Centro Nacional De Investigaciones Oncológicas Carlos Iii PROCEDURE FOR IDENTIFICATION OF THERAPEUTIC AGENTS AGAINST MELANOMA AND USE OF IDENTIFIED AGENT.
EP2281579A1 (en) 2009-08-05 2011-02-09 BioNTech AG Vaccine composition comprising 5'-Cap modified RNA
RU2411935C1 (en) * 2009-08-25 2011-02-20 Учреждение Российской академии медицинских наук Научно-исследовательский институт биомедицинской химии им. В.Н. Ореховича РАМН (ИБМХ РАМН) Pharmaceutical composition based on doxorubicine and phospholipid nanoparticles for treatment of oncologic diseases
US20110053829A1 (en) 2009-09-03 2011-03-03 Curevac Gmbh Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids
GB0920258D0 (en) 2009-11-19 2010-01-06 Alligator Bioscience Ab New medical agents and use thereof
WO2011069529A1 (en) 2009-12-09 2011-06-16 Curevac Gmbh Mannose-containing solution for lyophilization, transfection and/or injection of nucleic acids
LT2590676T (en) 2010-07-06 2016-10-25 Glaxosmithkline Biologicals Sa Virion-like delivery particles for self-replicating rna molecules
EP2449113B8 (en) 2010-07-30 2015-11-25 CureVac AG Complexation of nucleic acids with disulfide-crosslinked cationic components for transfection and immunostimulation
WO2012019630A1 (en) 2010-08-13 2012-02-16 Curevac Gmbh Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded protein
EP2910572B1 (en) 2010-11-11 2017-09-06 Versitech Limited Soluble pd-1 variants, fusion constructs, and uses thereof
WO2012089225A1 (en) 2010-12-29 2012-07-05 Curevac Gmbh Combination of vaccination and inhibition of mhc class i restricted antigen presentation
WO2012116715A1 (en) 2011-03-02 2012-09-07 Curevac Gmbh Vaccination in newborns and infants
WO2012113413A1 (en) * 2011-02-21 2012-08-30 Curevac Gmbh Vaccine composition comprising complexed immunostimulatory nucleic acids and antigens packaged with disulfide-linked polyethyleneglycol/peptide conjugates
WO2012116714A1 (en) 2011-03-02 2012-09-07 Curevac Gmbh Vaccination in elderly patients
WO2013053775A1 (en) 2011-10-11 2013-04-18 Universität Zürich Prorektorat Mnw Combination medicament comprising il-12 and an agent for blockade of t-cell inhibitory molecules for tumour therapy
WO2013059475A1 (en) 2011-10-18 2013-04-25 Life Technologies Corporation Alkynyl-derivatized cap analogs, preparation and uses thereof
KR20220132652A (en) 2011-12-12 2022-09-30 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 Compositions, comprising improved il-12 genetic constructs and vaccines, immunotherapeutics and methods of using the same
EP2623121A1 (en) * 2012-01-31 2013-08-07 Bayer Innovation GmbH Pharmaceutical composition comprising a polymeric carrier cargo complex and an antigen
WO2013113325A1 (en) 2012-01-31 2013-08-08 Curevac Gmbh Negatively charged nucleic acid comprising complexes for immunostimulation
WO2013113326A1 (en) 2012-01-31 2013-08-08 Curevac Gmbh Pharmaceutical composition comprising a polymeric carrier cargo complex and at least one protein or peptide antigen
WO2013120497A1 (en) 2012-02-15 2013-08-22 Curevac Gmbh Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded therapeutic protein
WO2013120499A1 (en) 2012-02-15 2013-08-22 Curevac Gmbh Nucleic acid comprising or coding for a histone stem-loop and a poly (a) sequence or a polyadenylation signal for increasing the expression of an encoded pathogenic antigen
WO2013120500A1 (en) 2012-02-15 2013-08-22 Curevac Gmbh Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded tumour antigen
WO2013120498A1 (en) 2012-02-15 2013-08-22 Curevac Gmbh Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded allergenic antigen or an autoimmune self-antigen
WO2013143555A1 (en) 2012-03-26 2013-10-03 Biontech Ag Rna formulation for immunotherapy
AU2013242404B2 (en) 2012-03-27 2018-08-30 CureVac SE Artificial nucleic acid molecules for improved protein or peptide expression
ES2660459T3 (en) 2012-03-27 2018-03-22 Curevac Ag Artificial Nucleic Acid Molecules
CN104321432B (en) 2012-03-27 2018-08-10 库瑞瓦格股份公司 Include the artificial nucleic acid molecule of 5 ' TOP UTR
US20150306249A1 (en) 2012-05-25 2015-10-29 Curevac Gmbh Reversible immobilization and/or controlled release of nucleic acid containing nanoparticles by (biodegradable) polymer coatings
US9872909B2 (en) 2012-09-17 2018-01-23 Galeotin Therapeutics, Inc. Method for enhancing specific immunotherapies in cancer treatment
CN109045289A (en) 2013-02-22 2018-12-21 库瑞瓦格股份公司 Vaccine inoculation and the combination for inhibiting PD-1 approach
AU2014268836B2 (en) 2013-05-18 2018-08-02 Aduro Biotech, Inc. Compositions and methods for activating "stimulator of interferon gene"-dependent signalling
CA2915730A1 (en) 2013-08-21 2015-02-26 Karl-Josef Kallen A combination rsv/influenza a vaccine
WO2015024667A1 (en) 2013-08-21 2015-02-26 Curevac Gmbh Method for increasing expression of rna-encoded proteins
SG11201510748PA (en) 2013-08-21 2016-03-30 Curevac Ag Composition and vaccine for treating lung cancer
RU2016109938A (en) 2013-08-21 2017-09-26 Куревак Аг COMPOSITION AND VACCINE FOR TREATMENT OF PROSTATE CANCER
CA2915712A1 (en) 2013-08-21 2015-02-26 Margit SCHNEE Rabies vaccine
JP6896421B2 (en) 2013-08-21 2021-06-30 キュアバック アーゲー Respiratory syncytial virus (RSV) vaccine
EP3052106A4 (en) 2013-09-30 2017-07-19 ModernaTX, Inc. Polynucleotides encoding immune modulating polypeptides
ES2806575T3 (en) 2013-11-01 2021-02-18 Curevac Ag Modified RNA with decreased immunostimulatory properties
EP3083666A4 (en) 2013-12-18 2017-09-20 Intrexon Corporation Single chain il-12 nucleic acids, polypeptids, and uses thereof
WO2015101415A1 (en) 2013-12-30 2015-07-09 Curevac Gmbh Artificial nucleic acid molecules
SG11201603144QA (en) 2013-12-30 2016-07-28 Curevac Ag Artificial nucleic acid molecules
AU2014375404C1 (en) 2013-12-30 2020-11-19 CureVac Manufacturing GmbH Methods for RNA analysis
CA2935878C (en) 2014-03-12 2023-05-02 Curevac Ag Combination of vaccination and ox40 agonists
CA2936286A1 (en) 2014-04-01 2015-10-08 Curevac Ag Polymeric carrier cargo complex for use as an immunostimulating agent or as an adjuvant
WO2016048903A1 (en) 2014-09-22 2016-03-31 Intrexon Corporation Improved therapeutic control of heterodimeric and single chain forms of interleukin-12
US20160120949A1 (en) 2014-10-31 2016-05-05 Neumedicines, Inc. Uses of il-12 in hematopoietic immunotherapy (hit)
BR112017020952A2 (en) 2015-04-13 2018-07-10 Five Prime Therapeutics Inc cancer treatment method, composition and use of composition
JP6912384B2 (en) 2015-04-22 2021-08-04 キュアバック アーゲー RNA-containing compositions for the treatment of cancer diseases
US20180291089A1 (en) * 2015-04-30 2018-10-11 University Of Southern California Secretory tnt car cell immunotherapy
DK3319587T3 (en) 2015-11-17 2019-11-25 Bioncotech Therapeutics S L A NEW PHARMACEUTICAL COMPOSITION CONTAINING PARTICLES CONTAINING A COMPLEX OF A DOUBLE-STRANDED POLYRIBONUCLEOTIDE AND A POLYALKYLENIMINE
WO2017123675A1 (en) 2016-01-11 2017-07-20 Synlogic, Inc. Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells

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