EP3337466A4 - Novel polygodial analogs for the treatment of cancer and other proliferative diseases - Google Patents

Novel polygodial analogs for the treatment of cancer and other proliferative diseases Download PDF

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Publication number
EP3337466A4
EP3337466A4 EP16839838.6A EP16839838A EP3337466A4 EP 3337466 A4 EP3337466 A4 EP 3337466A4 EP 16839838 A EP16839838 A EP 16839838A EP 3337466 A4 EP3337466 A4 EP 3337466A4
Authority
EP
European Patent Office
Prior art keywords
polygodial
analogs
cancer
novel
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP16839838.6A
Other languages
German (de)
French (fr)
Other versions
EP3337466A1 (en
Inventor
Cara B GONZALES
Alexander Kornienko
Ramesh Dasari
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Texas State University San Marcos
University of Texas System
Original Assignee
Texas State University San Marcos
University of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Texas State University San Marcos, University of Texas System filed Critical Texas State University San Marcos
Publication of EP3337466A1 publication Critical patent/EP3337466A1/en
Publication of EP3337466A4 publication Critical patent/EP3337466A4/en
Withdrawn legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00Preparation of carboxylic acid esters
    • C07C67/30Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C13/00Cyclic hydrocarbons containing rings other than, or in addition to, six-membered aromatic rings
    • C07C13/28Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof
    • C07C13/32Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings
    • C07C13/47Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings with a bicyclo ring system containing ten carbon atoms
    • C07C13/48Completely or partially hydrogenated naphthalenes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • C07C255/01Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/31Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing rings other than six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56Ring systems containing three or more rings
    • C07D209/58[b]- or [c]-condensed
    • C07D209/62Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4018Esters of cycloaliphatic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14All rings being cycloaliphatic
    • C07C2602/26All rings being cycloaliphatic the ring system containing ten carbon atoms
    • C07C2602/28Hydrogenated naphthalenes
EP16839838.6A 2015-08-22 2016-08-17 Novel polygodial analogs for the treatment of cancer and other proliferative diseases Withdrawn EP3337466A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562208656P 2015-08-22 2015-08-22
PCT/US2016/047401 WO2017034893A1 (en) 2015-08-22 2016-08-17 Novel polygodial analogs for the treatment of cancer and other proliferative diseases

Publications (2)

Publication Number Publication Date
EP3337466A1 EP3337466A1 (en) 2018-06-27
EP3337466A4 true EP3337466A4 (en) 2019-07-17

Family

ID=58100688

Family Applications (1)

Application Number Title Priority Date Filing Date
EP16839838.6A Withdrawn EP3337466A4 (en) 2015-08-22 2016-08-17 Novel polygodial analogs for the treatment of cancer and other proliferative diseases

Country Status (3)

Country Link
US (1) US20180237362A1 (en)
EP (1) EP3337466A4 (en)
WO (1) WO2017034893A1 (en)

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ANDRE E ET AL: "Evidence for the involvement of vanilloid receptor in the antinociception produced by the dialdeydes unsaturated sesquiterpenes polygodial and drimanial in rats", NEUROPHARMACOLOGY, PERGAMON PRESS, OXFORD, GB, vol. 46, no. 4, 1 March 2004 (2004-03-01), pages 590 - 597, XP027516257, ISSN: 0028-3908, [retrieved on 20040212], DOI: 10.1016/J.NEUROPHARM.2003.10.008 *

Also Published As

Publication number Publication date
EP3337466A1 (en) 2018-06-27
WO2017034893A1 (en) 2017-03-02
US20180237362A1 (en) 2018-08-23

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Ipc: C07C 13/48 20060101ALI20190611BHEP

Ipc: C07F 9/00 20060101ALI20190611BHEP

Ipc: A61K 31/01 20060101AFI20190611BHEP

Ipc: A61P 35/02 20060101ALI20190611BHEP

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