ATE305801T1 - Intratumorale verabreichung nackter il-12 codierender nukleinsäuremoleküle - Google Patents

Intratumorale verabreichung nackter il-12 codierender nukleinsäuremoleküle

Info

Publication number
ATE305801T1
ATE305801T1 AT01911481T AT01911481T ATE305801T1 AT E305801 T1 ATE305801 T1 AT E305801T1 AT 01911481 T AT01911481 T AT 01911481T AT 01911481 T AT01911481 T AT 01911481T AT E305801 T1 ATE305801 T1 AT E305801T1
Authority
AT
Austria
Prior art keywords
nucleic acid
naked
acid molecules
encoding nucleic
intratumoral administration
Prior art date
Application number
AT01911481T
Other languages
English (en)
Inventor
Karin Moelling
Jan Schultz
Lucie Heinzerling
Original Assignee
Univ Zuerich Inst Fuer Medizin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Zuerich Inst Fuer Medizin filed Critical Univ Zuerich Inst Fuer Medizin
Application granted granted Critical
Publication of ATE305801T1 publication Critical patent/ATE305801T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/208—IL-12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT01911481T 2000-01-20 2001-01-12 Intratumorale verabreichung nackter il-12 codierender nukleinsäuremoleküle ATE305801T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00101108 2000-01-20
PCT/EP2001/000363 WO2001052874A2 (en) 2000-01-20 2001-01-12 Intra-tumoral administration of il-12 encoding nucleic acid molecules

Publications (1)

Publication Number Publication Date
ATE305801T1 true ATE305801T1 (de) 2005-10-15

Family

ID=8167670

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01911481T ATE305801T1 (de) 2000-01-20 2001-01-12 Intratumorale verabreichung nackter il-12 codierender nukleinsäuremoleküle

Country Status (8)

Country Link
US (1) US7141550B2 (de)
EP (1) EP1248654B1 (de)
JP (1) JP2003525222A (de)
AT (1) ATE305801T1 (de)
AU (1) AU4050801A (de)
DE (1) DE60113805T2 (de)
ES (1) ES2246314T3 (de)
WO (1) WO2001052874A2 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1248654B1 (de) 2000-01-20 2005-10-05 Universität Zürich Institut für Medizinische Virologie Intratumorale verabreichung nackter il-12 codierender nukleinsäuremoleküle
EP2251034B1 (de) 2005-12-02 2018-02-14 Icahn School of Medicine at Mount Sinai Chimäre newcastle disease viren zur präsentation von nicht -nativen oberflächenproteinen und deren verwendung
WO2011119920A2 (en) 2010-03-25 2011-09-29 Oregon Health & Science University Cmv glycoproteins and recombinant vectors
RS57397B8 (sr) 2011-06-10 2020-01-31 Univ Oregon Health & Science Cmv glikoproteini i rekombinantni vektori
EP2568289A3 (de) 2011-09-12 2013-04-03 International AIDS Vaccine Initiative Immunselektion von rekombinantem vesikulärem Stomatitisvirus mit Expression von HIV-1-Proteinen durch Breitbandneutralisierungs-Antikörper
EP3351261B1 (de) 2011-10-11 2021-06-02 Universität Zürich Kombinationsmedikament mit il-12 und einem mittel zur blockade von t-zell-inhibitormolekülen zur tumortherapie
EP2586461A1 (de) 2011-10-27 2013-05-01 Christopher L. Parks Von einem eingehüllten Virus abgeleitete Virenpartikel
ES2631608T3 (es) 2012-06-27 2017-09-01 International Aids Vaccine Initiative Variante de la glicoproteína Env del VIH-1
SG10201802982WA (en) 2013-03-14 2018-06-28 Icahn School Med Mount Sinai Newcastle disease viruses and uses thereof
US20150065381A1 (en) 2013-09-05 2015-03-05 International Aids Vaccine Initiative Methods of identifying novel hiv-1 immunogens
EP2873423B1 (de) 2013-10-07 2017-05-31 International Aids Vaccine Initiative Lösliche hiv-1-hüllglykoproteintrimere
CA2940570A1 (en) 2014-02-27 2015-09-03 Viralytics Limited Combination method for treatment of cancer
EP3069730A3 (de) 2015-03-20 2017-03-15 International Aids Vaccine Initiative Lösliche hiv-1-hüllglykoproteintrimere
US9931394B2 (en) 2015-03-23 2018-04-03 International Aids Vaccine Initiative Soluble HIV-1 envelope glycoprotein trimers
CN108064176A (zh) 2015-04-22 2018-05-22 库瑞瓦格股份公司 用于治疗肿瘤疾病的含有rna的组合物
WO2017083291A1 (en) 2015-11-09 2017-05-18 Immune Design Corp. Compositions comprising lentiviral vectors expressing il-12 and methods of use thereof
LT3458083T (lt) * 2016-05-18 2023-02-10 Modernatx, Inc. Polinukleotidai, koduojantys interleukiną-12 (il12), ir jų naudojimas
EP3458092A1 (de) 2016-05-18 2019-03-27 Modernatx, Inc. Mrna-kombinationstherapie zur behandlung von krebs
WO2018033254A2 (en) * 2016-08-19 2018-02-22 Curevac Ag Rna for cancer therapy
CR20190444A (es) 2017-02-28 2019-12-17 Sanofi Sa Arn terapéutico
JOP20190256A1 (ar) 2017-05-12 2019-10-28 Icahn School Med Mount Sinai فيروسات داء نيوكاسل واستخداماتها
EP3625246A1 (de) 2017-05-18 2020-03-25 ModernaTX, Inc. Polynukleotide zur codierung von gebundenen interleukin-12 (il12)-polypeptiden und verwendungen davon
CA3063983A1 (en) 2017-05-24 2018-11-29 Novartis Ag Antibody-cytokine engrafted proteins and methods of use in the treatment of cancer
CN111617235A (zh) * 2017-09-07 2020-09-04 康立泰药业有限公司 Il-12在术后抗肿瘤方面的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1248654B1 (de) 2000-01-20 2005-10-05 Universität Zürich Institut für Medizinische Virologie Intratumorale verabreichung nackter il-12 codierender nukleinsäuremoleküle
JP4147724B2 (ja) * 2000-06-09 2008-09-10 ソニー株式会社 アンテナ装置及び無線装置

Also Published As

Publication number Publication date
ES2246314T3 (es) 2006-02-16
US7141550B2 (en) 2006-11-28
EP1248654B1 (de) 2005-10-05
JP2003525222A (ja) 2003-08-26
WO2001052874A3 (en) 2001-12-20
EP1248654A2 (de) 2002-10-16
AU4050801A (en) 2001-07-31
US20030118564A1 (en) 2003-06-26
WO2001052874A2 (en) 2001-07-26
WO2001052874A9 (en) 2003-05-30
DE60113805D1 (de) 2006-02-16
DE60113805T2 (de) 2006-07-13

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