ATE305801T1 - Intratumorale verabreichung nackter il-12 codierender nukleinsäuremoleküle - Google Patents

Intratumorale verabreichung nackter il-12 codierender nukleinsäuremoleküle

Info

Publication number
ATE305801T1
ATE305801T1 AT01911481T AT01911481T ATE305801T1 AT E305801 T1 ATE305801 T1 AT E305801T1 AT 01911481 T AT01911481 T AT 01911481T AT 01911481 T AT01911481 T AT 01911481T AT E305801 T1 ATE305801 T1 AT E305801T1
Authority
AT
Austria
Prior art keywords
nucleic acid
naked
acid molecules
encoding nucleic
intratumoral administration
Prior art date
Application number
AT01911481T
Other languages
English (en)
Inventor
Karin Moelling
Jan Schultz
Lucie Heinzerling
Original Assignee
Univ Zuerich Inst Fuer Medizin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Zuerich Inst Fuer Medizin filed Critical Univ Zuerich Inst Fuer Medizin
Application granted granted Critical
Publication of ATE305801T1 publication Critical patent/ATE305801T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/208—IL-12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT01911481T 2000-01-20 2001-01-12 Intratumorale verabreichung nackter il-12 codierender nukleinsäuremoleküle ATE305801T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00101108 2000-01-20
PCT/EP2001/000363 WO2001052874A2 (en) 2000-01-20 2001-01-12 Intra-tumoral administration of il-12 encoding nucleic acid molecules

Publications (1)

Publication Number Publication Date
ATE305801T1 true ATE305801T1 (de) 2005-10-15

Family

ID=8167670

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01911481T ATE305801T1 (de) 2000-01-20 2001-01-12 Intratumorale verabreichung nackter il-12 codierender nukleinsäuremoleküle

Country Status (8)

Country Link
US (1) US7141550B2 (de)
EP (1) EP1248654B1 (de)
JP (1) JP2003525222A (de)
AT (1) ATE305801T1 (de)
AU (1) AU4050801A (de)
DE (1) DE60113805T2 (de)
ES (1) ES2246314T3 (de)
WO (1) WO2001052874A2 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE305801T1 (de) 2000-01-20 2005-10-15 Univ Zuerich Inst Fuer Medizin Intratumorale verabreichung nackter il-12 codierender nukleinsäuremoleküle
EA016217B1 (ru) 2005-12-02 2012-03-30 Маунт Синай Скул Оф Медсин Химерные вирусы, представляющие неприродные поверхностные белки, и их применение
EP2550362B1 (de) 2010-03-25 2017-01-04 Oregon Health&Science University Cmv-glycoproteine und rekombinante vektoren
CA2832109C (en) 2011-06-10 2021-07-06 Oregon Health & Science University Cmv glycoproteins and recombinant vectors
AU2012216792A1 (en) 2011-09-12 2013-03-28 International Aids Vaccine Initiative Immunoselection of recombinant vesicular stomatitis virus expressing HIV-1 proteins by broadly neutralizing antibodies
EP2766035B1 (de) 2011-10-11 2018-03-28 Universität Zürich Prorektorat MNW Kombinationsmedikament mit il-12 und einem mittel zur blockade von t-zellen-hemmer-molekülen zur tumortherapie
US9402894B2 (en) 2011-10-27 2016-08-02 International Aids Vaccine Initiative Viral particles derived from an enveloped virus
EP2679596B1 (de) 2012-06-27 2017-04-12 International Aids Vaccine Initiative HIV-1 Env-proteinvariante
JP6596411B2 (ja) 2013-03-14 2019-10-23 アイカーン スクール オブ メディシン アット マウント サイナイ ニューカッスル病ウイルス及びその使用
US20150065381A1 (en) 2013-09-05 2015-03-05 International Aids Vaccine Initiative Methods of identifying novel hiv-1 immunogens
EP2873423B1 (de) 2013-10-07 2017-05-31 International Aids Vaccine Initiative Lösliche hiv-1-hüllglykoproteintrimere
KR102407019B1 (ko) 2014-02-27 2022-06-08 머크 샤프 앤드 돔 코포레이션 암의 치료를 위한 결합 방법
EP3069730A3 (de) 2015-03-20 2017-03-15 International Aids Vaccine Initiative Lösliche hiv-1-hüllglykoproteintrimere
EP3072901A1 (de) 2015-03-23 2016-09-28 International Aids Vaccine Initiative Lösliche hiv-1-hüllglykoproteintrimere
BR112017018368B1 (pt) 2015-04-22 2022-08-02 Curevac Ag Composição contendo rna para uso no tratamento ou profilaxia de doenças tumorais e/ou cancerosas, e uso de um rna para a preparação da composição
AU2016354000A1 (en) 2015-11-09 2018-05-17 Immune Design Corp. Compositions comprising lentiviral vectors expressing IL-12 and methods of use thereof
RS63912B1 (sr) 2016-05-18 2023-02-28 Modernatx Inc Polinukleotidi koji kodiraju interleukin-12 (il12) i njihove upotrebe
AU2017268399B2 (en) 2016-05-18 2023-01-12 Modernatx, Inc. mRNA combination therapy for the treatment of cancer
EP3500295A2 (de) * 2016-08-19 2019-06-26 CureVac AG Rna zur krebstherapie
PE20200735A1 (es) 2017-02-28 2020-07-23 Sanofi Sa Arn terapeutico
JOP20190256A1 (ar) 2017-05-12 2019-10-28 Icahn School Med Mount Sinai فيروسات داء نيوكاسل واستخداماتها
CA3063723A1 (en) 2017-05-18 2018-11-22 Modernatx, Inc. Polynucleotides encoding tethered interleukin-12 (il12) polypeptides and uses thereof
WO2018215936A1 (en) 2017-05-24 2018-11-29 Novartis Ag Antibody-cytokine engrafted proteins and methods of use in the treatment of cancer
CN111714620A (zh) * 2017-09-07 2020-09-29 康立泰药业有限公司 Il-12在术后抗肿瘤方面的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE305801T1 (de) 2000-01-20 2005-10-15 Univ Zuerich Inst Fuer Medizin Intratumorale verabreichung nackter il-12 codierender nukleinsäuremoleküle
JP4147724B2 (ja) * 2000-06-09 2008-09-10 ソニー株式会社 アンテナ装置及び無線装置

Also Published As

Publication number Publication date
US7141550B2 (en) 2006-11-28
DE60113805T2 (de) 2006-07-13
EP1248654A2 (de) 2002-10-16
ES2246314T3 (es) 2006-02-16
JP2003525222A (ja) 2003-08-26
WO2001052874A2 (en) 2001-07-26
DE60113805D1 (de) 2006-02-16
WO2001052874A3 (en) 2001-12-20
US20030118564A1 (en) 2003-06-26
WO2001052874A9 (en) 2003-05-30
EP1248654B1 (de) 2005-10-05
AU4050801A (en) 2001-07-31

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