MX2021011753A - Degradadores de moleculas peque?as de stat3. - Google Patents

Degradadores de moleculas peque?as de stat3.

Info

Publication number
MX2021011753A
MX2021011753A MX2021011753A MX2021011753A MX2021011753A MX 2021011753 A MX2021011753 A MX 2021011753A MX 2021011753 A MX2021011753 A MX 2021011753A MX 2021011753 A MX2021011753 A MX 2021011753A MX 2021011753 A MX2021011753 A MX 2021011753A
Authority
MX
Mexico
Prior art keywords
sup
stat3
small molecule
degraders
formula
Prior art date
Application number
MX2021011753A
Other languages
English (en)
Inventor
Donna Mceachern
Longchuan Bai
Shaomeng Wang
Jeanne Stuckey
Renqi Xu
Haibin Zhou
Chao - Yie Yang
Original Assignee
Univ Michigan Regents
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Michigan Regents filed Critical Univ Michigan Regents
Publication of MX2021011753A publication Critical patent/MX2021011753A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3882—Arylalkanephosphonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente descripción proporciona compuestos representados por la Fórmula I o la Fórmula VIII (ver fòrmulas) o , donde R1a, R1b, M, A, E, QA y QB son tal como se definen en la memoria descriptiva, y sales y solvatos de estos. Los compuestos con la Fórmula I son degradadores de STAT3 o degradadores de STAT3 y STAT1. Los compuestos con la Fórmula VIII son inhibidores de STAT3. Los degradadores e inhibidores de STAT3 son útiles para el tratamiento del cáncer y otras enfermedades.
MX2021011753A 2019-03-26 2020-03-26 Degradadores de moleculas peque?as de stat3. MX2021011753A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962823949P 2019-03-26 2019-03-26
US201962884995P 2019-08-09 2019-08-09
PCT/US2020/024892 WO2020198435A1 (en) 2019-03-26 2020-03-26 Small molecule degraders of stat3

Publications (1)

Publication Number Publication Date
MX2021011753A true MX2021011753A (es) 2022-01-31

Family

ID=70286026

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021011753A MX2021011753A (es) 2019-03-26 2020-03-26 Degradadores de moleculas peque?as de stat3.

Country Status (12)

Country Link
US (1) US20230083015A1 (es)
EP (1) EP3946619A1 (es)
JP (1) JP2022527298A (es)
KR (1) KR20220009941A (es)
CN (1) CN114269763A (es)
AU (1) AU2020248002A1 (es)
CA (1) CA3134822A1 (es)
IL (1) IL286567A (es)
MA (1) MA55516A (es)
MX (1) MX2021011753A (es)
SG (1) SG11202110449YA (es)
WO (1) WO2020198435A1 (es)

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EP4112614A4 (en) 2020-02-25 2023-09-06 Shanghaitech University GLUTARIMIDE BACKGROUND-BASED COMPOUNDS AND USE THEREOF
CN115776891A (zh) * 2020-03-17 2023-03-10 凯麦拉医疗公司 Stat降解剂和其用途
EP4367112A1 (en) 2021-07-09 2024-05-15 Plexium, Inc. Aryl compounds and pharmaceutical compositions that modulate ikzf2
WO2023133336A1 (en) * 2022-01-10 2023-07-13 Recludix Pharma, Inc. Stat modulators and uses thereof
CN117126231A (zh) * 2022-05-25 2023-11-28 杭州和正医药有限公司 拟肽类stat蛋白降解剂、组合物及其应用

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ES2654064T3 (es) 2002-07-03 2024-03-13 Ono Pharmaceutical Co Composiciones inmunopotenciadoras que comprenden anticuerpos anti-PD-L1
KR101339628B1 (ko) 2005-05-09 2013-12-09 메다렉스, 인코포레이티드 예정 사멸 인자 1(ｐｄ-1)에 대한 인간 모노클로날 항체, 및 항-ｐｄ-1 항체를 단독 사용하거나 기타 면역 요법제와 병용한 암 치료 방법
PL2170959T3 (pl) 2007-06-18 2014-03-31 Merck Sharp & Dohme Przeciwciała przeciwko ludzkiemu receptorowi programowanej śmierci PD-1
AR072999A1 (es) 2008-08-11 2010-10-06 Medarex Inc Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
PL2350129T3 (pl) 2008-08-25 2015-12-31 Amplimmune Inc Kompozycje antagonistów PD-1 i sposoby stosowania
US20110319362A1 (en) * 2008-12-08 2011-12-29 Shaomeng Wang Stat3 ligands and therapeutic uses thereof
KR20210060670A (ko) 2008-12-09 2021-05-26 제넨테크, 인크. 항-ｐｄ-ｌ１ 항체 및 ｔ 세포 기능을 향상시키기 위한 그의 용도
JP4965623B2 (ja) 2009-09-30 2012-07-04 インターナショナル・ビジネス・マシーンズ・コーポレーション 所定のソフトウェアの実行パラメータを入力フィールドへ入力することを支援するための方法、システム、およびプログラム
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Also Published As

Publication number Publication date
CA3134822A1 (en) 2020-10-01
IL286567A (en) 2021-12-01
US20230083015A1 (en) 2023-03-16
JP2022527298A (ja) 2022-06-01
WO2020198435A1 (en) 2020-10-01
SG11202110449YA (en) 2021-10-28
KR20220009941A (ko) 2022-01-25
EP3946619A1 (en) 2022-02-09
AU2020248002A1 (en) 2021-10-21
CN114269763A (zh) 2022-04-01
MA55516A (fr) 2022-02-09

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