MX2021008294A - Compuestos antiproliferativos y segundos agentes activos para uso en el tratamiento del mieloma múltiple. - Google Patents

Compuestos antiproliferativos y segundos agentes activos para uso en el tratamiento del mieloma múltiple.

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Publication number
MX2021008294A
MX2021008294A MX2021008294A MX2021008294A MX2021008294A MX 2021008294 A MX2021008294 A MX 2021008294A MX 2021008294 A MX2021008294 A MX 2021008294A MX 2021008294 A MX2021008294 A MX 2021008294A MX 2021008294 A MX2021008294 A MX 2021008294A
Authority
MX
Mexico
Prior art keywords
inhibitor
multiple myeloma
active agents
treating multiple
active agent
Prior art date
Application number
MX2021008294A
Other languages
English (en)
Inventor
Lilly L Wong
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of MX2021008294A publication Critical patent/MX2021008294A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
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    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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Abstract

En la presente se proporcionan métodos de uso de 4-(4-(4-(((2-(2,6-dioxopiperidin-3-il)-1- oxoisoindolin-4-il) oxi)metil)bencil)piperazin-1-il)-3-fluorobenzonitrilo, o un enantiómero, una mezcla de enantiómeros, un tautómero o una sal farmacéuticamente aceptable de los mismos, en combinación con un segundo agente activo para tratar, prevenir o controlar el mieloma múltiple. El segundo agente activo es uno o más de un inhibidor de BTK, un inhibidor de mTOR, un inhibidor de PIM, un inhibidor de IGF-1R, uninhibidor de MEK, un inhibidor de XPO1, un inhibidor de DOT1L, un inhibidor de EZH2, un inhibidor de JAK2, un inhibidor de BRD4, un inhibidor de PLK1, un inhibidor de NEK2, un inhibidor de AURKB, un inhibidor de BIRC5, un inhibidor de BET o un inhibidor de metiltransferasa de ADN.
MX2021008294A 2019-01-09 2020-01-08 Compuestos antiproliferativos y segundos agentes activos para uso en el tratamiento del mieloma múltiple. MX2021008294A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962790326P 2019-01-09 2019-01-09
PCT/US2020/012647 WO2020146440A1 (en) 2019-01-09 2020-01-08 Antiproliferative compounds and second active agents for use in treating multiple myeloma

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MX2021008294A true MX2021008294A (es) 2021-10-13

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US (2) US11660297B2 (es)
EP (1) EP3908281A1 (es)
JP (1) JP7467479B2 (es)
KR (1) KR20210126011A (es)
CN (2) CN114404596A (es)
AU (1) AU2020205643A1 (es)
BR (1) BR112021013290A2 (es)
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