EA201891479A1 - Композиции и способы модулирования экспрессии hbv и ttr - Google Patents
Композиции и способы модулирования экспрессии hbv и ttrInfo
- Publication number
- EA201891479A1 EA201891479A1 EA201891479A EA201891479A EA201891479A1 EA 201891479 A1 EA201891479 A1 EA 201891479A1 EA 201891479 A EA201891479 A EA 201891479A EA 201891479 A EA201891479 A EA 201891479A EA 201891479 A1 EA201891479 A1 EA 201891479A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- ttr
- hbv
- modulating
- expression
- compositions
- Prior art date
Links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A—HUMAN NECESSITIES
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
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Abstract
В настоящем документе предложены олигомерные соединения с конъюгированными группами. В некоторых вариантах реализации изобретения олигомерные соединения конъюгированы с N-ацетилгалактозамином.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361818442P | 2013-05-01 | 2013-05-01 | |
US201361823826P | 2013-05-15 | 2013-05-15 | |
US201361843887P | 2013-07-08 | 2013-07-08 | |
US201361871673P | 2013-08-29 | 2013-08-29 | |
US201361880790P | 2013-09-20 | 2013-09-20 | |
US201461976991P | 2014-04-08 | 2014-04-08 | |
US201461986867P | 2014-04-30 | 2014-04-30 |
Publications (2)
Publication Number | Publication Date |
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EA201891479A1 true EA201891479A1 (ru) | 2018-11-30 |
EA036584B1 EA036584B1 (ru) | 2020-11-26 |
Family
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Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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EA201891479A EA036584B1 (ru) | 2013-05-01 | 2014-05-01 | Композиции и способы модулирования экспрессии hbv и ttr |
EA201592093A EA031393B1 (ru) | 2013-05-01 | 2014-05-01 | Композиции и способы модулирования экспрессии hbv и ttr |
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EA201592093A EA031393B1 (ru) | 2013-05-01 | 2014-05-01 | Композиции и способы модулирования экспрессии hbv и ttr |
Country Status (35)
Country | Link |
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US (23) | US9714421B2 (ru) |
EP (11) | EP2992098B1 (ru) |
JP (20) | JP6769866B2 (ru) |
KR (16) | KR20210014758A (ru) |
CN (12) | CN113293163A (ru) |
AU (19) | AU2014259759B2 (ru) |
BR (5) | BR112015027319A8 (ru) |
CA (5) | CA2921509A1 (ru) |
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2021
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2022
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2023
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2024
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