BR112015027377A2 - Compostos oligoméricos com grupos de conjugado, composições compreendendo os referidos compostos e usos dos mesmos - Google Patents
Compostos oligoméricos com grupos de conjugado, composições compreendendo os referidos compostos e usos dos mesmosInfo
- Publication number
- BR112015027377A2 BR112015027377A2 BR112015027377A BR112015027377A BR112015027377A2 BR 112015027377 A2 BR112015027377 A2 BR 112015027377A2 BR 112015027377 A BR112015027377 A BR 112015027377A BR 112015027377 A BR112015027377 A BR 112015027377A BR 112015027377 A2 BR112015027377 A2 BR 112015027377A2
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- apociii
- disorders
- oligomeric
- conditions
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 8
- 239000000203 mixture Substances 0.000 title abstract 2
- 102000030169 Apolipoprotein C-III Human genes 0.000 abstract 7
- 108010056301 Apolipoprotein C-III Proteins 0.000 abstract 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 7
- 208000035475 disorder Diseases 0.000 abstract 4
- 201000010099 disease Diseases 0.000 abstract 3
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- OVRNDRQMDRJTHS-CBQIKETKSA-N N-Acetyl-D-Galactosamine Chemical compound CC(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@H](O)[C@@H]1O OVRNDRQMDRJTHS-CBQIKETKSA-N 0.000 abstract 1
- MBLBDJOUHNCFQT-UHFFFAOYSA-N N-acetyl-D-galactosamine Natural products CC(=O)NC(C=O)C(O)C(O)C(O)CO MBLBDJOUHNCFQT-UHFFFAOYSA-N 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 208000030159 metabolic disease Diseases 0.000 abstract 1
Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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Abstract
COMPOSTOS OLIGOMÉRICOS COM GRUPOS DE CONJUGADO, COMPOSIÇÕES COMPREENDENDO OS REFERIDOS COMPOSTOS E USOS DOS MESMOS. São fornecidos aqui compostos oligoméricos com grupos de conjugado que se direcionam à apolipoproteína C- III (ApoCIII). Em determinadas modalidades, os compostos oligoméricos que se direcionam à ApoCIII estão conjugados à N-Acetilgalactosamina. Também são divulgados aqui compostos conjugados oligoméric os que se direcionam à ApoCIII para uso na diminuição da ApoCIII para tratar, prevenir ou melhorar doenças, distúrbios ou condições relacionadas à ApoCIII. Determinadas doenças, distúrbios ou condições relacionadas à ApoCIII incluem doenças, distúrbios ou condições inflamatórias, cardiovasculares e/ou metabólicas. Os compostos oligoméricos conjugados divulgados aqui podem ser usados para tratar tais doenças, distúrbios ou condições em um indivíduo em necessidade.
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