BR112015027322A8 - Compostos antissenso conjugados e sua utilização - Google Patents
Compostos antissenso conjugados e sua utilizaçãoInfo
- Publication number
- BR112015027322A8 BR112015027322A8 BR112015027322A BR112015027322A BR112015027322A8 BR 112015027322 A8 BR112015027322 A8 BR 112015027322A8 BR 112015027322 A BR112015027322 A BR 112015027322A BR 112015027322 A BR112015027322 A BR 112015027322A BR 112015027322 A8 BR112015027322 A8 BR 112015027322A8
- Authority
- BR
- Brazil
- Prior art keywords
- conjugated anti
- sense compounds
- compounds
- sense
- conjugated
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 230000000692 anti-sense effect Effects 0.000 title abstract 2
- OVRNDRQMDRJTHS-CBQIKETKSA-N N-Acetyl-D-Galactosamine Chemical compound CC(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@H](O)[C@@H]1O OVRNDRQMDRJTHS-CBQIKETKSA-N 0.000 abstract 1
- MBLBDJOUHNCFQT-UHFFFAOYSA-N N-acetyl-D-galactosamine Natural products CC(=O)NC(C=O)C(O)C(O)C(O)CO MBLBDJOUHNCFQT-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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- Liquid Crystal Substances (AREA)
Abstract
COMPOSTOS ANTISSENSO CONJUGADOS, SEU USO, COMPOSIÇÃO FARMACÊUTICA QUE OS COMPREENDE, PROFÁRMACO. São fornecidos neste documento compostos oligoméricos com grupos de conjugado. Em determinadas modalidades, os compostos oligoméricos são conjugados com a N-Acetilgalactosamina.
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