US4866042A
(en)
|
1987-11-18 |
1989-09-12 |
Neuwelt Edward A |
Method for the delivery of genetic material across the blood brain barrier
|
US6294520B1
(en)
|
1989-03-27 |
2001-09-25 |
Albert T. Naito |
Material for passage through the blood-brain barrier
|
US7101993B1
(en)
|
1990-01-11 |
2006-09-05 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides containing 2′-O-modified purines
|
US5914396A
(en)
|
1990-01-11 |
1999-06-22 |
Isis Pharmaceuticals, Inc. |
2'-O-modified nucleosides and phosphoramidites
|
US5151510A
(en)
|
1990-04-20 |
1992-09-29 |
Applied Biosystems, Inc. |
Method of synethesizing sulfurized oligonucleotide analogs
|
AU661662B2
(en)
|
1990-08-13 |
1995-08-03 |
Isis Pharmaceuticals, Inc. |
Sugar modified oligonucleotides that detect and modulate gene expression
|
US7015315B1
(en)
|
1991-12-24 |
2006-03-21 |
Isis Pharmaceuticals, Inc. |
Gapped oligonucleotides
|
DE69333344T2
(de)
|
1992-07-23 |
2004-10-07 |
Isis Pharmaceutical Inc |
Neue 2'-0-Alkyl-Nukleoside und Phosphoramidite, Verfahren zu deren Herstellung und deren Verwendung
|
ES2312164T3
(es)
|
1992-09-25 |
2009-02-16 |
Aventis Pharma S.A. |
Vectores de adenovirus para la transferencia de genes extraños en celulas del sistema nervioso central, particularmente en el cerebro.
|
ES2290951T3
(es)
|
1993-05-11 |
2008-02-16 |
The University Of North Carolina At Chapel Hill |
Oligonucleotidos antisentido que combaten el corte y empalme aberrante y metodos de uso de los mismos.
|
AU1322795A
(en)
|
1993-12-24 |
1995-07-17 |
Erasmus University Rotterdam |
Tuberous sclerosis 2 gene and uses thereof
|
US5656612A
(en)
|
1994-05-31 |
1997-08-12 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of raf gene expression
|
FR2727867B1
(fr)
|
1994-12-13 |
1997-01-31 |
Rhone Poulenc Rorer Sa |
Transfert de genes dans les motoneurones medullaires au moyen de vecteurs adenoviraux
|
US6166197A
(en)
|
1995-03-06 |
2000-12-26 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds having pyrimidine nucleotide (S) with 2'and 5 substitutions
|
DK0882061T3
(da)
|
1996-02-14 |
2004-09-27 |
Isis Pharmaceuticals Inc |
Sukkermodificerede gapped oligonukleotider
|
GB9605808D0
(en)
|
1996-03-20 |
1996-05-22 |
Isis Innovation |
CFTR gene regulator
|
US5898031A
(en)
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
US6770748B2
(en)
|
1997-03-07 |
2004-08-03 |
Takeshi Imanishi |
Bicyclonucleoside and oligonucleotide analogue
|
USRE44779E1
(en)
|
1997-03-07 |
2014-02-25 |
Santaris Pharma A/S |
Bicyclonucleoside and oligonucleotide analogues
|
JP3756313B2
(ja)
|
1997-03-07 |
2006-03-15 |
武 今西 |
新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
|
JP2002511750A
(ja)
|
1997-06-03 |
2002-04-16 |
マックス−プランク−ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ |
in vivoにおいて内皮細胞に異種DNA配列を発現させる能力のある制御配列とその使用法
|
US6963589B1
(en)
|
1997-07-03 |
2005-11-08 |
Canon Kabushiki Kaisha |
Information processing apparatus for and method of transmitting and/or receiving broadcast signal
|
GB9716231D0
(en)
|
1997-07-31 |
1997-10-08 |
Amersham Int Ltd |
Base analogues
|
DE04020014T1
(de)
|
1997-09-12 |
2006-01-26 |
Exiqon A/S |
Bi-zyklische - Nukleosid,Nnukleotid und Oligonukleotid-Analoga
|
US6794499B2
(en)
|
1997-09-12 |
2004-09-21 |
Exiqon A/S |
Oligonucleotide analogues
|
US7572582B2
(en)
|
1997-09-12 |
2009-08-11 |
Exiqon A/S |
Oligonucleotide analogues
|
US7045610B2
(en)
|
1998-04-03 |
2006-05-16 |
Epoch Biosciences, Inc. |
Modified oligonucleotides for mismatch discrimination
|
KR100608276B1
(ko)
|
1998-08-24 |
2006-08-02 |
무라마쯔 다카시 |
동맥경화 및 ptca술후의 혈관 재협착에 대한예방·치료제
|
US6210892B1
(en)
|
1998-10-07 |
2001-04-03 |
Isis Pharmaceuticals, Inc. |
Alteration of cellular behavior by antisense modulation of mRNA processing
|
US7071324B2
(en)
|
1998-10-13 |
2006-07-04 |
Brown University Research Foundation |
Systems and methods for sequencing by hybridization
|
US20030224514A1
(en)
|
2002-05-31 |
2003-12-04 |
Isis Pharmaceuticals Inc. |
Antisense modulation of PPAR-delta expression
|
US6436657B1
(en)
|
1998-12-18 |
2002-08-20 |
E. I. Du Pont De Nemours And Company |
Polynucleotides encoding aminomethyltransferases
|
BRPI0008131B8
(pt)
|
1999-02-12 |
2021-05-25 |
Daiichi Sankyo Co Ltd |
composto ou um sal deste, análogo de oligonucleotídeo, composição farmacêutica, sonda para um gene,iniciador para começar a amplificação, uso de um análogo de oligonucleotídeo ou de um sal deste farmacologicamente aceitável, agente antisentido, e, agente antígeno
|
ATE465168T1
(de)
|
1999-03-18 |
2010-05-15 |
Exiqon As |
Xylo-lna analoge
|
US7084125B2
(en)
|
1999-03-18 |
2006-08-01 |
Exiqon A/S |
Xylo-LNA analogues
|
US6734291B2
(en)
|
1999-03-24 |
2004-05-11 |
Exiqon A/S |
Synthesis of [2.2.1]bicyclo nucleosides
|
AU3418800A
(en)
|
1999-03-24 |
2000-10-09 |
Exiqon A/S |
Improved synthesis of (2.2.1)bicyclo nucleosides
|
US6383752B1
(en)
|
1999-03-31 |
2002-05-07 |
Hybridon, Inc. |
Pseudo-cyclic oligonucleobases
|
PT1178999E
(pt)
|
1999-05-04 |
2007-06-26 |
Santaris Pharma As |
Análogos de l-ribo-lna
|
US6083482A
(en)
|
1999-05-11 |
2000-07-04 |
Icn Pharmaceuticals, Inc. |
Conformationally locked nucleosides and oligonucleotides
|
US6531591B1
(en)
|
1999-07-07 |
2003-03-11 |
Exiqon A/S |
Synthesis of stable quinone and photoreactive ketone phosphoramidite reagents for solid phase synthesis of photoreactive-oligomer conjugates
|
JP4151751B2
(ja)
|
1999-07-22 |
2008-09-17 |
第一三共株式会社 |
新規ビシクロヌクレオシド類縁体
|
US6677445B1
(en)
|
1999-08-27 |
2004-01-13 |
Chiron Corporation |
Chimeric antisense oligonucleotides and cell transfecting formulations thereof
|
US6187586B1
(en)
|
1999-12-29 |
2001-02-13 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of AKT-3 expression
|
AU2001257526B2
(en)
|
2000-05-04 |
2007-07-19 |
Avi Biopharma, Inc. |
Splice-region antisense composition and method
|
US6809194B1
(en)
|
2000-05-10 |
2004-10-26 |
Chiron Corporation |
Akt3 inhibitors
|
JP2004504038A
(ja)
|
2000-07-13 |
2004-02-12 |
ザ ジョンズ ホプキンス ユニバーシティー スクール オブ メディシン |
多発性嚢胞腎疾患の検出と治療
|
AU2001282522A1
(en)
|
2000-08-29 |
2002-03-13 |
Takeshi Imanishi |
Novel nucleoside analogs and oligonucleotide derivatives containing these analogs
|
CA2420656A1
(en)
|
2000-09-02 |
2003-02-26 |
Grunenthal Gmbh |
Antisense oligonucleotides against vanilloid receptor 1
|
ATE325806T1
(de)
|
2000-10-04 |
2006-06-15 |
Santaris Pharma As |
Verbesserte synthese von purin-blockierten nukleinsäure-analoga
|
JP2002345489A
(ja)
|
2000-11-03 |
2002-12-03 |
Astrazeneca Ab |
化学物質
|
ATE287413T1
(de)
|
2001-07-12 |
2005-02-15 |
Santaris Pharma As |
Verfahren zur herstellung des lna phosphoramidite
|
WO2003016492A2
(en)
|
2001-08-16 |
2003-02-27 |
The Regents Of The University Of Michigan |
Adamts13 genes and proteins and variants, and uses thereof
|
EP1446412B1
(en)
|
2001-09-04 |
2012-03-07 |
Exiqon A/S |
Novel lna compositions and uses thereof
|
US6936589B2
(en)
|
2001-09-28 |
2005-08-30 |
Albert T. Naito |
Parenteral delivery systems
|
WO2003040395A2
(en)
|
2001-11-07 |
2003-05-15 |
Applera Corporation |
Universal nucleotides for nucleic acid analysis
|
JP4383176B2
(ja)
|
2002-02-13 |
2009-12-16 |
武 今西 |
ヌクレオシド類縁体およびそのヌクレオチド類縁体を含むオリゴヌクレオチド誘導体
|
US7569575B2
(en)
|
2002-05-08 |
2009-08-04 |
Santaris Pharma A/S |
Synthesis of locked nucleic acid derivatives
|
DE60315444T2
(de)
|
2002-05-08 |
2008-04-30 |
Santaris Pharma A/S |
Synthese von locked nucleic acid-derivaten
|
WO2004001010A2
(en)
|
2002-06-21 |
2003-12-31 |
Ptc Therapeutics, Inc. |
METHODS FOR IDENTIFYING SMALL MOLECULES THAT MODULATE PREMATURE TRANSLATION TERMINATION AND NONSENSE MEDIATED mRNA DECAY
|
RU2005106855A
(ru)
|
2002-08-12 |
2005-10-10 |
Дзе Риджентс оф дзе Юниверсити оф Мичиган (US) |
Диагностика и лечение заболеваний, вызываемых дефектами каскада реакций, обусловливающих туберозный склероз
|
US20060058253A1
(en)
|
2002-08-12 |
2006-03-16 |
Benoit Chabot |
Methods to reprogram splice site selection in pre-messenger rnas
|
EP1562971B1
(en)
|
2002-11-05 |
2014-02-12 |
Isis Pharmaceuticals, Inc. |
Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
|
WO2004042029A2
(en)
|
2002-11-05 |
2004-05-21 |
Isis Pharmaceuticals, Inc. |
Oligomers comprising modified bases for binding cytosine and uracil or thymine and their use
|
US7687617B2
(en)
|
2002-11-18 |
2010-03-30 |
Santaris Pharma A/S |
Oligonucleotides with alternating segments of locked and non-locked nucleotides
|
US7790867B2
(en)
|
2002-12-05 |
2010-09-07 |
Rosetta Genomics Inc. |
Vaccinia virus-related nucleic acids and microRNA
|
EP2239329A1
(en)
|
2003-03-07 |
2010-10-13 |
Alnylam Pharmaceuticals, Inc. |
Therapeutic compositions
|
DK2141234T3
(en)
|
2003-03-21 |
2016-06-20 |
Roche Innovation Ct Copenhagen As |
Short interfering RNA (siRNA) analogues
|
CA2524255C
(en)
|
2003-03-21 |
2014-02-11 |
Academisch Ziekenhuis Leiden |
Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure
|
JP5209204B2
(ja)
|
2003-04-13 |
2013-06-12 |
エンゾン ファーマスーティカルズ インコーポレイテッド |
ポリマーオリゴヌクレオチドプロドラッグ
|
US20050053981A1
(en)
|
2003-09-09 |
2005-03-10 |
Swayze Eric E. |
Gapped oligomeric compounds having linked bicyclic sugar moieties at the termini
|
US20070009899A1
(en)
|
2003-10-02 |
2007-01-11 |
Mounts William M |
Nucleic acid arrays for detecting gene expression in animal models of inflammatory diseases
|
GB0326578D0
(en)
|
2003-11-14 |
2003-12-17 |
Univ Belfast |
Cancer diagnosis and therapy
|
US20050221354A1
(en)
|
2004-02-18 |
2005-10-06 |
Wyeth |
Nucleic acid arrays for monitoring expression profiles of drug target genes
|
WO2005104785A2
(en)
|
2004-04-27 |
2005-11-10 |
Illumigen Biosciences, Inc. |
Methods and compositions for specifically targeting human hepatocellular carcinoma cells
|
EP2322650A1
(en)
|
2004-05-14 |
2011-05-18 |
Rosetta Genomics Ltd |
MicroRNAs and uses thereof
|
US8394947B2
(en)
|
2004-06-03 |
2013-03-12 |
Isis Pharmaceuticals, Inc. |
Positionally modified siRNA constructs
|
US20070087376A1
(en)
|
2004-08-30 |
2007-04-19 |
Potashkin Judith A |
Splice variants of pre-mRNA transcripts as biomarkers in idiopathic neurodegenerative diseases
|
CA2588646A1
(en)
|
2004-11-19 |
2006-05-26 |
Acadia Pharmaceuticals Inc. |
Methods to identify ligands of hormone nuclear receptors
|
WO2006081311A2
(en)
|
2005-01-26 |
2006-08-03 |
Medical College Of Georgia Research Institute |
Compositions and methods for the intracellular disruption of vegf and vegfr-2 by intraceptors
|
US7718625B2
(en)
|
2005-01-27 |
2010-05-18 |
University Of South Florida |
Polynucleotides targeted against the extended 5′-UTR region of argininosuccinate synthase and uses thereof
|
US20100150839A1
(en)
|
2005-02-04 |
2010-06-17 |
Massachusetts Institute Of Technology |
Compositions and Methods for Modulating Cognitive Function
|
CA2635198C
(en)
|
2005-04-01 |
2019-11-12 |
University Of Florida Research Foundation, Inc |
Biomarkers of liver injury
|
CA2612180A1
(en)
|
2005-06-16 |
2006-12-21 |
Bionomics Limited |
Methods of treatment, and diagnosis of epilepsy by detecting mutations in the scn1a gene
|
ES2382104T3
(es)
|
2005-06-17 |
2012-06-05 |
Baxter International Inc. |
Composiciones con actividad trombolítica que comprenden ADAMTS13
|
WO2007002390A2
(en)
|
2005-06-23 |
2007-01-04 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for modulation of smn2 splicing
|
HUE043492T2
(hu)
|
2005-08-23 |
2019-08-28 |
Univ Pennsylvania |
Módosított nukleozidokat tartalmazó RNS és eljárások az alkalmazására
|
WO2007028065A2
(en)
|
2005-08-30 |
2007-03-08 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds for modulation of splicing
|
US8258109B2
(en)
|
2005-10-20 |
2012-09-04 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for modulation of LMNA expression
|
WO2007048628A2
(en)
|
2005-10-28 |
2007-05-03 |
Max Planck Gesellschaft |
Structures of active guide rna molecules and method of selection
|
WO2007048629A2
(en)
|
2005-10-28 |
2007-05-03 |
MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. |
Modulation of rna silencing efficiency by argonaute proteins
|
WO2007053747A2
(en)
|
2005-11-01 |
2007-05-10 |
President And Fellows Of Harvard College |
Modulating endoplasmic reticulum stress in the treatment of tuberous sclerosis
|
US20090291437A1
(en)
*
|
2005-11-02 |
2009-11-26 |
O'brien Sean |
Methods for targeting quadruplex sequences
|
US7785834B2
(en)
|
2005-11-10 |
2010-08-31 |
Ercole Biotech, Inc. |
Soluble TNF receptors and their use in treatment of disease
|
EP1792981A1
(en)
|
2005-12-02 |
2007-06-06 |
Humboldt-Universität zu Berlin |
Microginin producing proteins and nucleic acids encoding a microginin gene cluster as well as methods for creating microginins
|
EP2422819B1
(en)
|
2006-01-26 |
2017-03-01 |
Ionis Pharmaceuticals, Inc. |
Compositions and their uses directed to Huntingtin
|
PL1984381T3
(pl)
|
2006-01-27 |
2011-03-31 |
Isis Pharmaceuticals Inc |
Zmodyfikowane w pozycji 6 analogi bicykliczne kwasów nukleinowych
|
JP5213723B2
(ja)
|
2006-01-27 |
2013-06-19 |
アイシス ファーマシューティカルズ, インコーポレーテッド |
マイクロrnaの調節に使用するためのオリゴマー化合物及び組成物
|
US7569686B1
(en)
|
2006-01-27 |
2009-08-04 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for synthesis of bicyclic nucleic acid analogs
|
US8007790B2
(en)
|
2006-04-03 |
2011-08-30 |
Stowers Institute For Medical Research |
Methods for treating polycystic kidney disease (PKD) or other cyst forming diseases
|
EP2015758B1
(en)
|
2006-05-05 |
2014-04-02 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating expression apob
|
US7547684B2
(en)
|
2006-05-11 |
2009-06-16 |
Isis Pharmaceuticals, Inc. |
5′-modified bicyclic nucleic acid analogs
|
US7666854B2
(en)
|
2006-05-11 |
2010-02-23 |
Isis Pharmaceuticals, Inc. |
Bis-modified bicyclic nucleic acid analogs
|
EP1857548A1
(en)
|
2006-05-19 |
2007-11-21 |
Academisch Ziekenhuis Leiden |
Means and method for inducing exon-skipping
|
WO2007142304A1
(ja)
|
2006-06-08 |
2007-12-13 |
Amino Up Chemical Co., Ltd. |
iNOSの発現制御作用を有するセンスオリゴヌクレオチド及びそれを含む組成物
|
US20090186946A1
(en)
|
2006-06-27 |
2009-07-23 |
Takeda Pharmaceutical Company Limited |
Genetically Modified Animal and Use Thereof
|
US8771946B2
(en)
|
2006-07-24 |
2014-07-08 |
Athena Diagnostics, Inc. |
PKD mutations and evaluation of same
|
ATE540118T1
(de)
|
2006-10-18 |
2012-01-15 |
Isis Pharmaceuticals Inc |
Antisense-verbindungen
|
US20090264353A1
(en)
|
2007-10-19 |
2009-10-22 |
Santaris Pharma A/S |
Splice Switching Oligomers for TNF Superfamily Receptors and their Use in Treatment of Disease
|
WO2007054100A2
(en)
|
2006-11-13 |
2007-05-18 |
Santaris Pharma A/S |
Lna nucleoside phosphoramidates
|
US8293684B2
(en)
|
2006-11-29 |
2012-10-23 |
Exiqon |
Locked nucleic acid reagents for labelling nucleic acids
|
WO2008086807A2
(en)
|
2007-01-19 |
2008-07-24 |
Exiqon A/S |
Mediated cellular delivery of lna oligonucleotides
|
EP2114981B1
(en)
|
2007-01-29 |
2013-05-08 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating protein expression
|
AR065648A1
(es)
|
2007-03-09 |
2009-06-24 |
Pioneer Hi Bred Int |
Identificacion de transportadores de amonio (amts) para la regulacion del metabolismo de nitrogeno en plantas
|
WO2008111485A1
(ja)
|
2007-03-09 |
2008-09-18 |
Riken |
モノヌクレオシドまたはモノヌクレオチドから誘導される構造を有する化合物、核酸、標識物質、核酸検出方法およびキット
|
EP2134736A4
(en)
|
2007-03-15 |
2013-05-29 |
Jyoti Chattopadhyaya |
FIVE- AND SIX-PIECE CONFORMATIVELY FIXED 2 ', 4'-CARBOCYCLIC RIBOTHYMIDINE FOR THE TREATMENT OF INFECTIONS AND CANCER
|
EP2149605B1
(en)
|
2007-03-22 |
2013-07-03 |
Santaris Pharma A/S |
Short RNA antagonist compounds for the modulation of target mRNA
|
US8278425B2
(en)
|
2007-05-30 |
2012-10-02 |
Isis Pharmaceuticals, Inc. |
N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
|
US8278426B2
(en)
|
2007-06-08 |
2012-10-02 |
Isis Pharmaceuticals, Inc. |
Carbocyclic bicyclic nucleic acid analogs
|
WO2009006478A2
(en)
|
2007-07-05 |
2009-01-08 |
Isis Pharmaceuticals, Inc. |
6-disubstituted bicyclic nucleic acid analogs
|
CN101821277B
(zh)
|
2007-08-15 |
2014-05-07 |
Isis制药公司 |
四氢吡喃核酸类似物
|
HUE028662T2
(en)
|
2007-10-26 |
2016-12-28 |
Academisch Ziekenhuis Leiden |
Preparations and methods for controlling muscle disorders
|
WO2009064920A2
(en)
|
2007-11-13 |
2009-05-22 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating protein expression
|
WO2009067647A1
(en)
|
2007-11-21 |
2009-05-28 |
Isis Pharmaceuticals, Inc. |
Carbocyclic alpha-l-bicyclic nucleic acid analogs
|
US20090247608A1
(en)
|
2007-12-04 |
2009-10-01 |
Alnylam Pharmaceuticals, Inc. |
Targeting Lipids
|
US8846386B2
(en)
|
2007-12-18 |
2014-09-30 |
University Of Kentucky Research Foundation |
sVEGFR-2 and its role in lymphangiogenesis modulation
|
WO2009084472A1
(ja)
|
2007-12-28 |
2009-07-09 |
Public University Corporation Yokohama City University |
新生児期~乳児期発症の難治性てんかんの検出方法
|
WO2009100320A2
(en)
|
2008-02-07 |
2009-08-13 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexitol nucleic acid analogs
|
JP5409658B2
(ja)
|
2008-03-13 |
2014-02-05 |
セレラ コーポレーション |
静脈血栓症に関連した遺伝子多型、その検出方法および使用
|
WO2009124295A2
(en)
|
2008-04-04 |
2009-10-08 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleosides and having reduced toxicity
|
EP2285819B1
(en)
|
2008-04-04 |
2013-10-16 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising neutrally linked terminal bicyclic nucleosides
|
US8710021B2
(en)
|
2008-06-11 |
2014-04-29 |
Bionucleon S.R.L. |
Inhibition of HRP-3 using modified oligonucleotides
|
EP2151248A1
(en)
|
2008-07-30 |
2010-02-10 |
Johann Bauer |
Improved pre-mRNA trans-splicing molecule (RTM) molecules and their uses
|
US8084601B2
(en)
|
2008-09-11 |
2011-12-27 |
Royal Holloway And Bedford New College Royal Holloway, University Of London |
Oligomers
|
WO2010036698A1
(en)
|
2008-09-24 |
2010-04-01 |
Isis Pharmaceuticals, Inc. |
Substituted alpha-l-bicyclic nucleosides
|
WO2010051632A1
(en)
|
2008-11-07 |
2010-05-14 |
Centre Hospitalier Universitaire Sainte-Justine |
Syngap1 dysfunctions and uses thereof in diagnostic and therapeutic applications for mental retardation
|
JP5971948B2
(ja)
|
2008-12-04 |
2016-08-17 |
クルナ・インコーポレーテッド |
Vegfに対する天然アンチセンス転写物の抑制による血管内皮増殖因子(vegf)関連疾患の治療
|
WO2010080509A1
(en)
|
2008-12-19 |
2010-07-15 |
Philadelphia Health And Education Corporation |
Compositions and methods for diminishing viral infection and inflammation associated with viral infection
|
US20100166784A1
(en)
|
2008-12-30 |
2010-07-01 |
The Washington University |
Method and compositions for modulating th17 cell development
|
US8680254B2
(en)
|
2009-01-14 |
2014-03-25 |
Philadelphia Health & Education Corporation |
Modulation of pre-mRNA using splice modulating oligonucleotides as therapeutic agents in the treatment of disease
|
KR101742334B1
(ko)
|
2009-05-08 |
2017-06-01 |
큐알엔에이, 인크. |
Dmd 패밀리에 대한 천연 안티센스 전사체의 억제에 의한 디스트로핀 패밀리 관련된 질환의 치료
|
NZ597071A
(en)
|
2009-06-17 |
2014-05-30 |
Isis Pharmaceuticals Inc |
Compositions and methods for modulation of smn2 splicing in a subject
|
EP2275545A1
(en)
|
2009-07-16 |
2011-01-19 |
Julius-Maximilians-Universität Würzburg |
Use of microRNA-24 and/or its targets for the treatment and prevention of ischemia and induction of angiogenesis
|
EP2462153B1
(en)
|
2009-08-06 |
2015-07-29 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexose nucleic acid analogs
|
WO2011020118A1
(en)
|
2009-08-14 |
2011-02-17 |
Theramind Research, Llc |
Methods and compositions for treatment of tuberous sclerosis complex
|
JP2013503646A
(ja)
|
2009-09-08 |
2013-02-04 |
ラボラトリー コーポレイション オブ アメリカ ホールディングス |
自閉症スペクトラム障害を診断するための組成物および方法
|
WO2011032034A2
(en)
|
2009-09-10 |
2011-03-17 |
University Of Idaho |
Nucleobase-functionalized conformationally restricted nucleotides and oligonucleotides for targeting nucleic acids
|
US8541562B2
(en)
|
2009-10-29 |
2013-09-24 |
Osaka University |
Bridged artificial nucleoside and nucleotide
|
PL2499249T3
(pl)
|
2009-11-12 |
2019-03-29 |
Univ Western Australia |
Cząsteczki antysensowne i sposoby leczenia patologii
|
AU2010324860A1
(en)
|
2009-11-25 |
2012-06-14 |
Dharmacon, Inc. |
Minor groove binder (MGB)-oligonucleotide miRNAs antagonists
|
WO2011085102A1
(en)
|
2010-01-11 |
2011-07-14 |
Isis Pharmaceuticals, Inc. |
Base modified bicyclic nucleosides and oligomeric compounds prepared therefrom
|
CA2789005A1
(en)
|
2010-02-08 |
2011-08-11 |
Isis Pharmaceuticals, Inc. |
Selective reduction of allelic variants
|
US9193752B2
(en)
|
2010-03-17 |
2015-11-24 |
Isis Pharmaceuticals, Inc. |
5′-substituted bicyclic nucleosides and oligomeric compounds prepared therefrom
|
JP2013529181A
(ja)
|
2010-03-25 |
2013-07-18 |
ザ ジェイ. デヴィッド グラッドストーン インスティテューツ |
神経障害を治療するための組成物および方法
|
WO2011127210A1
(en)
|
2010-04-06 |
2011-10-13 |
Massachusetts Institute Of Technology |
Targeted delivery of nucleic acids
|
US20110269735A1
(en)
|
2010-04-19 |
2011-11-03 |
Celera Corporation |
Genetic polymorphisms associated with statin response and cardiovascular diseases, methods of detection and uses thereof
|
CA2796722C
(en)
|
2010-04-19 |
2021-06-01 |
Nlife Therapeutics, S.L. |
Compositions and methods for selective delivery of oligonucleotide molecules to specific neuron types
|
US8802642B2
(en)
|
2010-04-28 |
2014-08-12 |
Iowa State University Research Foundation, Inc. |
Spinal muscular atrophy treatment via targeting SMN2 catalytic core
|
EP2606057B1
(en)
|
2010-04-28 |
2016-06-15 |
Ionis Pharmaceuticals, Inc. |
Modified 5' diphosphate nucleosides and oligomeric compounds prepared therefrom
|
EP2571530A4
(en)
|
2010-05-20 |
2014-03-05 |
Univ Rochester |
METHOD AND COMPOSITIONS FOR AUTOPHAGIA MODULATION
|
US8957200B2
(en)
|
2010-06-07 |
2015-02-17 |
Isis Pharmaceuticals, Inc. |
Bicyclic nucleosides and oligomeric compounds prepared therefrom
|
WO2011156202A1
(en)
|
2010-06-08 |
2011-12-15 |
Isis Pharmaceuticals, Inc. |
Substituted 2 '-amino and 2 '-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
|
US9518259B2
(en)
|
2010-06-15 |
2016-12-13 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating interaction between proteins and target nucleic acids
|
DK2585596T3
(da)
|
2010-06-23 |
2021-04-06 |
Curna Inc |
Behandling af spændingsreguleret natriumkanal-alpha-underenhed (scna)-relaterede sygdomme ved inhibering af naturligt antisense-transkript til scna
|
US9222088B2
(en)
|
2010-10-22 |
2015-12-29 |
Curna, Inc. |
Treatment of alpha-L-iduronidase (IDUA) related diseases by inhibition of natural antisense transcript to IDUA
|
WO2012075040A2
(en)
|
2010-11-30 |
2012-06-07 |
Shire Human Genetic Therapies, Inc. |
mRNA FOR USE IN TREATMENT OF HUMAN GENETIC DISEASES
|
WO2012106529A1
(en)
|
2011-02-02 |
2012-08-09 |
The Trustees Of Princeton University |
Jagged1 as a marker and therapeutic target for breast cancer bone metastasis
|
US20140128449A1
(en)
|
2011-04-07 |
2014-05-08 |
The Board Of Regents Of The University Of Texas System |
Oligonucleotide modulation of splicing
|
US9644035B2
(en)
|
2011-04-08 |
2017-05-09 |
Omeros Corporation |
Methods for treating conditions associated with MASP-2 dependent complement activation
|
CN106912197B
(zh)
|
2011-04-28 |
2022-01-25 |
生命技术公司 |
用于多重pcr的方法和组合物
|
DK2718437T3
(en)
|
2011-06-10 |
2018-08-06 |
Inst Nat Sante Rech Med |
Methods for the Treatment of Liver's Congenital Amaurosis
|
US20140357558A1
(en)
|
2011-06-24 |
2014-12-04 |
Cold Spring Harbor Laboratory |
Compositions and methods for treatment of spinal muscular atrophy
|
CN107365339A
(zh)
|
2011-07-19 |
2017-11-21 |
波涛生命科学有限公司 |
合成官能化核酸的方法
|
US8592156B2
(en)
|
2011-08-08 |
2013-11-26 |
Roche Molecular Systems, Inc. |
Predicting response to anti-CD20 therapy in DLBCL patients
|
DK2751270T3
(en)
|
2011-08-29 |
2018-10-29 |
Ionis Pharmaceuticals Inc |
OLIGOMER-CONJUGATE COMPLEXES AND THEIR USE
|
US9771580B2
(en)
|
2011-09-05 |
2017-09-26 |
Stichting Katholieke Universiteit |
Antisense oligonucleotides for the treatment of Leber congenital amaurosis
|
BR112014005234A2
(pt)
|
2011-09-06 |
2017-04-11 |
Curna Inc |
tratamento de doenças relacionadas com subunididades alfa dos canais de sódio dependentes de voltagem (scnxa) com pequenas moléculas
|
US9453261B2
(en)
|
2011-09-20 |
2016-09-27 |
The George Washington University |
Alternative splicing variants of genes associated with prostate cancer risk and survival
|
WO2013068441A1
(en)
|
2011-11-11 |
2013-05-16 |
Santaris Pharma A/S |
Compounds for the modulation of smn2 splicing
|
US9534222B2
(en)
|
2011-11-15 |
2017-01-03 |
University Of Utah Research Foundation |
Morpholinos, morpholino upregulating, and associated methods
|
CN104053786B
(zh)
|
2011-11-29 |
2017-06-06 |
生命技术公司 |
用于多重pcr的方法和组合物
|
WO2013106770A1
(en)
|
2012-01-11 |
2013-07-18 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for modulation of ikbkap splicing
|
US20140378533A1
(en)
|
2012-02-08 |
2014-12-25 |
Isis Pharmaceuticals, Inc. |
Modulation of rna by repeat targeting
|
US9586955B2
(en)
|
2012-02-10 |
2017-03-07 |
Ptc Therapeutics, Inc. |
Compounds for treating spinal muscular atrophy
|
US8846885B2
(en)
|
2012-02-17 |
2014-09-30 |
Ajinomoto Co., Inc. |
Oligonucleotide with protected base
|
EP2850092B1
(en)
|
2012-04-09 |
2017-03-01 |
Ionis Pharmaceuticals, Inc. |
Tricyclic nucleic acid analogs
|
WO2013159108A2
(en)
|
2012-04-20 |
2013-10-24 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleotides and uses thereof
|
US20140378526A1
(en)
|
2012-05-11 |
2014-12-25 |
City Of Hope |
Design of nucleic acid binding molecules with non-watson crick and non-canonical pairing based on artificial mutation consensus sequences to counter escape mutations
|
EP2852605B1
(en)
|
2012-05-22 |
2018-01-31 |
Idenix Pharmaceuticals LLC |
3',5'-cyclic phosphate prodrugs for hcv infection
|
US9109001B2
(en)
|
2012-05-22 |
2015-08-18 |
Idenix Pharmaceuticals, Inc. |
3′,5′-cyclic phosphoramidate prodrugs for HCV infection
|
EP2859102A4
(en)
|
2012-06-08 |
2016-05-11 |
Shire Human Genetic Therapies |
NUCLEASE RESISTANT POLYNUCLEOTIDES AND USES THEREOF
|
PL2872147T3
(pl)
|
2012-07-13 |
2023-09-25 |
Wave Life Sciences Ltd. |
Sposób wytwarzania chiralnych oligonukleotydów
|
US8729263B2
(en)
|
2012-08-13 |
2014-05-20 |
Novartis Ag |
1,4-disubstituted pyridazine analogs there of and methods for treating SMN-deficiency-related conditions
|
AU2013306006B2
(en)
|
2012-08-20 |
2017-07-06 |
The Regents Of The University Of California |
Polynucleotides having bioreversible groups
|
AU2013319788B2
(en)
|
2012-09-24 |
2019-04-11 |
Yissum Reasearch Development Company of the Hebrew University Of Jerusalem Ltd. |
Restoration of the CFTR function by splicing modulation
|
WO2014049536A2
(en)
|
2012-09-25 |
2014-04-03 |
Universidade De Lisboa |
Drug targets for cystic fibrosis and other conditions
|
EP2900682A1
(en)
|
2012-09-27 |
2015-08-05 |
IDENIX Pharmaceuticals, Inc. |
Esters and malonates of sate prodrugs
|
UA116639C2
(uk)
|
2012-10-09 |
2018-04-25 |
Рег'Юлес Терап'Ютікс Інк. |
Способи лікування синдрому альпорта
|
US9029335B2
(en)
|
2012-10-16 |
2015-05-12 |
Isis Pharmaceuticals, Inc. |
Substituted 2′-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
|
WO2014066915A2
(en)
|
2012-10-26 |
2014-05-01 |
Smith Larry J |
Methods and compositions to produce ss-rnai activity with enhanced potency
|
WO2014078749A1
(en)
|
2012-11-15 |
2014-05-22 |
The Regents Of The University Of California |
Splice modulating oligonucleotides that inhibit cancer
|
US9211300B2
(en)
|
2012-12-19 |
2015-12-15 |
Idenix Pharmaceuticals Llc |
4′-fluoro nucleosides for the treatment of HCV
|
CN104004826B
(zh)
|
2013-01-07 |
2016-03-02 |
赵晨 |
突变的基因prpf4在制备遗传性视网膜疾病诊断试剂中的应用
|
AU2014206668A1
(en)
|
2013-01-18 |
2015-08-06 |
Anna Mary Rose |
Therapeutics and diagnostics based on minisatellite repeat element 1 (MSR1)
|
EP3778618A1
(en)
|
2013-02-04 |
2021-02-17 |
Ionis Pharmaceuticals, Inc. |
Selective antisense compounds and uses thereof
|
JP6292631B2
(ja)
|
2013-02-18 |
2018-03-14 |
塩野義製薬株式会社 |
含窒素複素環構造を有するヌクレオシド及びヌクレオチド
|
US9339541B2
(en)
|
2013-03-04 |
2016-05-17 |
Merck Sharp & Dohme Corp. |
Thiophosphate nucleosides for the treatment of HCV
|
WO2014137926A1
(en)
|
2013-03-04 |
2014-09-12 |
Idenix Pharmaceuticals, Inc. |
3'-deoxy nucleosides for the treatment of hcv
|
EP2981542B1
(en)
|
2013-04-01 |
2021-09-15 |
Idenix Pharmaceuticals LLC |
2',4'-fluoro nucleosides for the treatment of hcv
|
WO2014172698A1
(en)
|
2013-04-19 |
2014-10-23 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for modulation nucleic acids through nonsense mediated decay
|
MX2015015239A
(es)
|
2013-05-01 |
2016-10-03 |
Ionis Pharmaceuticals Inc |
Composiciones y metodos.
|
US9549909B2
(en)
|
2013-05-03 |
2017-01-24 |
The Katholieke Universiteit Leuven |
Method for the treatment of dravet syndrome
|
US9637744B2
(en)
|
2013-06-13 |
2017-05-02 |
Inserm (Institut National De La Sante Et De La Recherche Medicale) |
Methods and pharmaceutical compositions for the treatment of erythropoietic protoporphyria
|
WO2014201413A1
(en)
|
2013-06-14 |
2014-12-18 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating non-coding rna
|
WO2014209841A2
(en)
|
2013-06-25 |
2014-12-31 |
F. Hoffmann-La Roche Ag |
Compounds for treating spinal muscular atrophy
|
EP3033422A4
(en)
|
2013-08-16 |
2017-08-02 |
Rana Therapeutics Inc. |
Oligonucleotides targeting euchromatin regions of genes
|
US20160201063A1
(en)
|
2013-08-16 |
2016-07-14 |
Rana Therapeutics, Inc. |
Epigenetic regulators of frataxin
|
MX2016002044A
(es)
|
2013-08-16 |
2016-08-17 |
Rana Therapeutics Inc |
Composiciones y metodos para modular el acido ribonucleico.
|
EP3033425A4
(en)
|
2013-08-16 |
2017-07-26 |
Rana Therapeutics, Inc. |
Compositions and methods for modulating expression of frataxin
|
JP6689197B2
(ja)
|
2013-08-19 |
2020-04-28 |
エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト |
スクリーニング方法
|
EP3690048A1
(en)
|
2013-09-04 |
2020-08-05 |
Cold Spring Harbor Laboratory |
Reducing nonsense-mediated mrna decay
|
IL300444A
(en)
|
2013-09-05 |
2023-04-01 |
Sarepta Therapeutics Inc |
Inclusion of exon 2 is induced by antisense in acid alpha-glucosidase
|
US10059947B2
(en)
|
2013-09-11 |
2018-08-28 |
Synthena Ag |
Nucleic acids and methods for the treatment of Pompe disease
|
IL298654A
(en)
|
2013-11-21 |
2023-01-01 |
Memorial Sloan Kettering Cancer Center |
Characterization of the origin of a functional cranial placode from human pluripotent stem cells
|
US10119168B2
(en)
|
2014-03-12 |
2018-11-06 |
The Brigham And Women's Hospital, Inc. |
Methods for the treatment of kidney fibrosis
|
US20170044540A1
(en)
|
2014-04-22 |
2017-02-16 |
Mina Therapeutics Limited |
Sarna compositions and methods of use
|
EP3155100B1
(en)
|
2014-06-10 |
2021-12-22 |
Erasmus University Medical Center Rotterdam |
Antisense oligonucleotides useful in treatment of pompe disease
|
GB201410693D0
(en)
|
2014-06-16 |
2014-07-30 |
Univ Southampton |
Splicing modulation
|
GB201411468D0
(en)
|
2014-06-27 |
2014-08-13 |
Univ Edinburgh |
Novel treatment for endometriosis
|
GB2547586A
(en)
|
2014-08-20 |
2017-08-23 |
Lifesplice Pharma Llc |
Splice modulating oligonucleotides and methods of use thereof(In the PCT request)
|
WO2016027168A2
(en)
|
2014-08-20 |
2016-02-25 |
Lifesplice Pharma Llc |
Splice modulating oligonucleotides and methods of use thereof
|
US9976143B2
(en)
|
2014-10-03 |
2018-05-22 |
Cold Spring Harbor Laboratory |
Targeted augmentation of nuclear gene output
|
US20170224758A1
(en)
|
2014-10-17 |
2017-08-10 |
The Broad Institute, Inc. |
Compositions and methods of treating muscular dystrophy
|
WO2016077837A1
(en)
|
2014-11-14 |
2016-05-19 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for the modulation of proteins
|
GB201421379D0
(en)
|
2014-12-02 |
2015-01-14 |
Isis Innovation Ltd And Medical Res Council |
Molecule
|
JP2018509387A
(ja)
|
2015-01-21 |
2018-04-05 |
フェーズアールエックス インコーポレイテッド |
細胞に治療および診断剤を送達するための方法、組成物、ならびにシステム
|
EP3256126B1
(en)
|
2015-02-09 |
2024-03-27 |
F. Hoffmann-La Roche AG |
Compounds for the treatment of cancer
|
EP3259356B1
(en)
|
2015-02-20 |
2021-12-01 |
Rosalind Franklin University of Medicine and Science |
Antisense compounds targeting genes associated with cystic fibrosis
|
JP2018509143A
(ja)
|
2015-02-27 |
2018-04-05 |
サレプタ セラピューティクス,インコーポレイテッド |
酸性アルファ−グルコシダーゼにおけるアンチセンスに誘導されるエクソン2の組入れ
|
KR102539587B1
(ko)
|
2015-04-03 |
2023-06-01 |
아이오니스 파마수티컬즈, 인코포레이티드 |
Tmprss6 발현을 조절하기 위한 화합물 및 방법들
|
WO2016196386A1
(en)
|
2015-05-30 |
2016-12-08 |
Ptc Therapeutics, Inc. |
Methods for modulating rna splicing
|
EP3352872A4
(en)
|
2015-09-24 |
2019-07-10 |
The Trustees of the University of Pennsylvania |
TRIPTYCENE DERIVATIVES FOR STABILIZING NUCLEIC ACID JUNITIONS
|
GB2591194B
(en)
|
2015-10-09 |
2021-10-13 |
Univ Southampton |
Modulation of gene expression and screening for deregulated protein expression
|
SG11201802870RA
(en)
|
2015-10-09 |
2018-05-30 |
Univ Southampton |
Modulation of gene expression and screening for deregulated protein expression
|
CA3003132A1
(en)
|
2015-10-30 |
2017-05-04 |
Ptc Therapeutics, Inc. |
Methods for treating epilepsy
|
CA3005090A1
(en)
|
2015-12-14 |
2017-06-22 |
Cold Spring Harbor Laboratory |
Compositions and methods for treatment of liver diseases
|
JP2018538287A
(ja)
|
2015-12-14 |
2018-12-27 |
コールド スプリング ハーバー ラボラトリー |
多発性嚢胞腎の処置のためのアンチセンスオリゴマー
|
US11096956B2
(en)
|
2015-12-14 |
2021-08-24 |
Stoke Therapeutics, Inc. |
Antisense oligomers and uses thereof
|
CA3005256A1
(en)
|
2015-12-14 |
2017-06-22 |
Cold Spring Harbor Laboratory |
Antisense oligomers for treatment of autosomal dominant mental retardation-5 and dravet syndrome
|
ES2903394T3
(es)
*
|
2015-12-14 |
2022-04-01 |
Cold Spring Harbor Laboratory |
Composiciones para el tratamiento de la retinitis pigmentosa 13
|
WO2017106210A1
(en)
|
2015-12-14 |
2017-06-22 |
Cold Spring Harbor Laboratory |
Antisense oligomers for treatment of alagille syndrome
|
CA3005128A1
(en)
|
2015-12-14 |
2017-06-22 |
Cold Spring Harbor Laboratory |
Compositions and methods for treatment of eye diseases
|
WO2017106292A1
(en)
|
2015-12-14 |
2017-06-22 |
Cold Spring Harbor Laboratory |
Compositions and methods for treatment of kidney diseases
|
WO2017106375A1
(en)
|
2015-12-14 |
2017-06-22 |
Cold Spring Harbor Laboratory |
Antisense oligomers for treatment of tuberous sclerosis complex
|
EP4104867A3
(en)
|
2015-12-14 |
2023-03-01 |
Cold Spring Harbor Laboratory |
Compositions and methods for treatment of central nervous system diseases
|
WO2017180587A2
(en)
|
2016-04-11 |
2017-10-19 |
Obsidian Therapeutics, Inc. |
Regulated biocircuit systems
|
CN118542952A
(zh)
|
2016-07-06 |
2024-08-27 |
沃泰克斯药物股份有限公司 |
用于治疗疼痛相关病症的材料和方法
|
EP3512870B1
(en)
|
2016-09-16 |
2022-08-03 |
Olipass Corporation |
Scn9a antisense oligonucleotides
|
JP7246359B2
(ja)
|
2017-04-03 |
2023-03-27 |
エンコーデッド セラピューティクス, インコーポレイテッド |
組織選択的導入遺伝子発現
|
US10765646B2
(en)
|
2017-04-13 |
2020-09-08 |
Ovid Therapeutics Inc. |
Methods of treating developmental encephalopathies
|
KR20190142364A
(ko)
|
2017-05-09 |
2019-12-26 |
조게닉스 인터내셔널 리미티드 |
펜플루라민을 사용하여 두즈 증후군을 치료하는 방법
|
WO2018213491A1
(en)
|
2017-05-16 |
2018-11-22 |
Praxis Precision Medicines, Inc. |
Methods of treating epilepsy and neurodevelopmental disorders
|
SG10202108375XA
(en)
*
|
2017-08-25 |
2021-09-29 |
Stoke Therapeutics Inc |
Antisense oligomers for treatment of conditions and diseases
|
KR20200070367A
(ko)
|
2017-10-23 |
2020-06-17 |
스톡 테라퓨틱스, 인크. |
넌센스 매개 rna 분해 기반 병태 및 질환 치료를 위한 안티센스 올리고머
|
WO2019109051A1
(en)
|
2017-12-01 |
2019-06-06 |
Encoded Therapeutics, Inc. |
Engineered dna binding proteins
|
US20210024907A1
(en)
|
2018-03-27 |
2021-01-28 |
Factor Bioscience Inc. |
Nucleic acid-based therapeutics
|
AU2019253700A1
(en)
|
2018-04-09 |
2020-11-26 |
Allen Institute |
Rescuing voltage-gated sodium channel function in inhibitory neurons
|
WO2019224864A1
(ja)
|
2018-05-21 |
2019-11-28 |
国立研究開発法人理化学研究所 |
Scn1a遺伝子の発現増強法とそれによるドラベ症候群の治療法
|
EP3806834A4
(en)
|
2018-05-25 |
2022-07-27 |
The Florey Institute of Neuroscience and Mental Health |
DYNAMIC CLAMPS AND METHODS OF USE THEREOF
|
WO2019236750A2
(en)
|
2018-06-05 |
2019-12-12 |
Tufts Medical Center, Inc. |
Targeted treatment of autism spectrum disorder and other neurological or psychiatric disorders
|
SG11202012161RA
(en)
|
2018-06-22 |
2021-01-28 |
Hoffmann La Roche |
Oligonucleotides for modulating scn9a expression
|
BR112021003224A2
(pt)
|
2018-08-20 |
2021-07-20 |
Rogcon, Inc. |
oligonucleotídeos antissentido direcionados a scn2a para o tratamento de encefalopatias por scn1a
|
US10905778B2
(en)
|
2018-09-26 |
2021-02-02 |
Case Western Reserve University |
Methods and compositions for treating a premature stop codon-mediated disorder
|
SG11202109371VA
(en)
|
2019-02-27 |
2021-09-29 |
Stoke Therapeutics Inc |
Antisense oligomers for treatment of conditions and diseases
|
CN116334086A
(zh)
*
|
2023-03-29 |
2023-06-27 |
广州医科大学附属第二医院 |
一种用于修复或抑制SCN1A基因异常剪接的U1-snRNA及其用途
|