SG11201802870RA - Modulation of gene expression and screening for deregulated protein expression - Google Patents

Modulation of gene expression and screening for deregulated protein expression

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Publication number
SG11201802870RA
SG11201802870RA SG11201802870RA SG11201802870RA SG11201802870RA SG 11201802870R A SG11201802870R A SG 11201802870RA SG 11201802870R A SG11201802870R A SG 11201802870RA SG 11201802870R A SG11201802870R A SG 11201802870RA SG 11201802870R A SG11201802870R A SG 11201802870RA
Authority
SG
Singapore
Prior art keywords
screening
modulation
expression
gene expression
deregulated protein
Prior art date
Application number
SG11201802870RA
Inventor
Igor Vorechovsky
Jana Kralovicova
Original Assignee
Univ Southampton
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB1517937.7A external-priority patent/GB2546719B/en
Priority claimed from GB1614744.9A external-priority patent/GB2559100A/en
Application filed by Univ Southampton filed Critical Univ Southampton
Publication of SG11201802870RA publication Critical patent/SG11201802870RA/en

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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SG11201802870RA 2015-10-09 2016-10-07 Modulation of gene expression and screening for deregulated protein expression SG11201802870RA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1517937.7A GB2546719B (en) 2015-10-09 2015-10-09 Modulation of gene expression and screening for deregulated protein expression
GB1614744.9A GB2559100A (en) 2016-08-31 2016-08-31 Modulation of gene expression and screening for deregulated protein expression
PCT/GB2016/053136 WO2017060731A1 (en) 2015-10-09 2016-10-07 Modulation of gene expression and screening for deregulated protein expression

Publications (1)

Publication Number Publication Date
SG11201802870RA true SG11201802870RA (en) 2018-05-30

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SG11201802870RA SG11201802870RA (en) 2015-10-09 2016-10-07 Modulation of gene expression and screening for deregulated protein expression

Country Status (10)

Country Link
US (4) US10196639B2 (en)
EP (1) EP3359685A1 (en)
JP (3) JP6923517B2 (en)
KR (2) KR20220105174A (en)
CN (1) CN108603230A (en)
AU (2) AU2016334804B2 (en)
CA (1) CA3000971A1 (en)
IL (2) IL308174A (en)
SG (1) SG11201802870RA (en)
WO (1) WO2017060731A1 (en)

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AU2016334804B2 (en) 2015-10-09 2022-03-31 University Of Southampton Modulation of gene expression and screening for deregulated protein expression
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CN109312343B (en) 2015-12-14 2022-09-27 冷泉港实验室 Antisense oligomers for the treatment of autosomal dominant mental retardation type 5 and Dravet syndrome
WO2019028440A1 (en) 2017-08-04 2019-02-07 Skyhawk Therapeutics, Inc. Methods and compositions for modulating splicing
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CN112334157A (en) * 2018-04-17 2021-02-05 应用干细胞有限公司 Compositions and methods for treating spinal muscular atrophy
US12060558B2 (en) 2018-05-04 2024-08-13 Stoke Therapeutics, Inc. Methods and compositions for treatment of cholesteryl ester storage disease
WO2019232251A1 (en) * 2018-05-30 2019-12-05 The Regents Of The University Of California Gene editing of monogenic disorders in human hematopoietic stem cells -- correction of x-linked hyper-igm syndrome (xhim)
JP2022521467A (en) 2019-02-05 2022-04-08 スカイホーク・セラピューティクス・インコーポレーテッド Methods and compositions for regulating splicing
JP2022519323A (en) 2019-02-06 2022-03-22 スカイホーク・セラピューティクス・インコーポレーテッド Methods and compositions for regulating splicing
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EP4017979A4 (en) * 2019-08-19 2024-03-27 Stoke Therapeutics, Inc. Compositions and methods for modulating splicing and protein expression
KR20220146501A (en) * 2020-02-12 2022-11-01 더 칠드런스 호스피탈 오브 필라델피아 Compositions and methods for inducible alternative splicing modulation of gene expression
CN111349649B (en) * 2020-03-16 2020-11-17 三峡大学 Method for gene editing of agaricus bisporus and application
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CA3204779A1 (en) * 2021-01-26 2022-08-04 Brage Storstein Andresen Splice switching oligonucleotides targeting pseudoexons
CN112908470B (en) * 2021-02-08 2023-10-03 深圳市人民医院 Hepatocellular carcinoma prognosis scoring system based on RNA binding protein gene and application thereof
WO2023144263A1 (en) * 2022-01-26 2023-08-03 Syddansk Universitet Allele specific splice switching oligonucleotides targeting pseudoexons

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