ES2086997T3 - Oligonucleotido-alquilfosfonatos y -alquilfosfonotioatos. - Google Patents

Oligonucleotido-alquilfosfonatos y -alquilfosfonotioatos.

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Publication number
ES2086997T3
ES2086997T3 ES94908639T ES94908639T ES2086997T3 ES 2086997 T3 ES2086997 T3 ES 2086997T3 ES 94908639 T ES94908639 T ES 94908639T ES 94908639 T ES94908639 T ES 94908639T ES 2086997 T3 ES2086997 T3 ES 2086997T3
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Spain
Prior art keywords
expression
oligonucleotide
virus
disclosed
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94908639T
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English (en)
Inventor
Ekambar R Kandimalla
Jamal Temsamani
Sudhir Agrawal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aceragen Inc
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Hybridon Inc
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Publication date
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Publication of ES2086997T3 publication Critical patent/ES2086997T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • C12N15/1132—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses against retroviridae, e.g. HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/312—Phosphonates
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/312—Phosphonates
    • C12N2310/3125—Methylphosphonates
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/316—Phosphonothioates
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/322—2'-R Modification
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3521—Methyl
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3523—Allyl
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3527—Other alkyl chain
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
    • C12N2310/3533—Halogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
    • C12N2310/3535—Nitrogen

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • AIDS & HIV (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

SE EXPONE UN OLIGONUCLEOTIDO ANALOGO QUE COMPRENDE AL MENOS UN RIBONUCLEOTIDO ALQUIFOSFONATO O ALQUIFOSFONOTIDO. DICHO ANALOGO TIENE PREFERIBLEMENTE ENTRE 2 Y 60 NUCLEOTIDOS EN LONGITUD, Y TIENE AL MENOS UN RIBONUCLEOTIDO SUSTITUIDO EN LA SEGUNDA POSICION DE SU GRUPO NERVIOSO. TAMBIEN SE EXPONEN FORMULACIONES TERAPEUTICAS QUE INCLUYEN ESTE OLIGONUCLEOTIDO ANALOGO, METODOS DE INHIBICION DE LA MANIFESTACION DE UN GEN MEDIANTE UN VIRUS, ORGANISMO PATOGENO, O CELULA, LA MANIFESTACION DE LA CUAL ES ASOCIADA CON UN ESTADO DE ENFERMEDAD, Y METODOS DE TRATAMIENTO DE UN MAMIFERO INFECTADO POR UN VIRUS U ORGANISMO PATOGENO O AFECTADO POR DESARREGLOS QUE RESULTAN DE LA MANIFESTACION DE UN GEN CELULAR.
ES94908639T 1993-01-25 1994-01-25 Oligonucleotido-alquilfosfonatos y -alquilfosfonotioatos. Expired - Lifetime ES2086997T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US926293A 1993-01-25 1993-01-25

Publications (1)

Publication Number Publication Date
ES2086997T3 true ES2086997T3 (es) 1996-07-01

Family

ID=21736582

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94908639T Expired - Lifetime ES2086997T3 (es) 1993-01-25 1994-01-25 Oligonucleotido-alquilfosfonatos y -alquilfosfonotioatos.

Country Status (14)

Country Link
EP (1) EP0677056B1 (es)
JP (1) JPH08508714A (es)
KR (1) KR960701077A (es)
CN (1) CN1121721A (es)
AT (1) ATE138384T1 (es)
AU (1) AU6165494A (es)
CA (1) CA2154578A1 (es)
DE (1) DE69400208T2 (es)
DK (1) DK0677056T3 (es)
ES (1) ES2086997T3 (es)
FI (1) FI953541A (es)
GR (1) GR3020557T3 (es)
NZ (1) NZ262254A (es)
WO (1) WO1994017093A1 (es)

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EP0677056B1 (en) 1996-05-22
EP0677056A1 (en) 1995-10-18
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DE69400208T2 (de) 1996-11-28
FI953541A (fi) 1995-08-31
CA2154578A1 (en) 1994-08-04
DE69400208D1 (en) 1996-06-27
NZ262254A (en) 1997-10-24
WO1994017093A1 (en) 1994-08-04
DK0677056T3 (da) 1996-08-05
JPH08508714A (ja) 1996-09-17
ATE138384T1 (de) 1996-06-15

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