DK1013661T4 - 2'-O,4'-C-methylen bicyklonukleosider - Google Patents
2'-O,4'-C-methylen bicyklonukleosider Download PDFInfo
- Publication number
- DK1013661T4 DK1013661T4 DK98905804.5T DK98905804T DK1013661T4 DK 1013661 T4 DK1013661 T4 DK 1013661T4 DK 98905804 T DK98905804 T DK 98905804T DK 1013661 T4 DK1013661 T4 DK 1013661T4
- Authority
- DK
- Denmark
- Prior art keywords
- group
- compound
- nucleic acid
- pyrimidine
- acid base
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (14)
1. Nukleosid af den følgende generelle formel (I) hvor B er en pyrimidin- eller purin-nukleinsyrebase, eller en analog deraf, og X og Y er identiske eller forskellige, og repræsenterer hver et hydrogenatom, en alkylgruppe, en alkenylgruppe, en alkynylgruppe, en cycloalkylgruppe, en arylgruppe, en acylgruppe, eller en silylgruppe, eller et amiditderivat deraf.
2. Nukleosidanalog ifølge krav 1, hvor pyrimidin- eller purin-nukleinsyrebasen er valgt fra thymin, uracil, cytosin, adenin, guanin, eller et derivat deraf.
3. Nukleosidanalog ifølge krav 1, hvor pyrimidin- eller purin-nukleinsyrebasen er thymin eller et derivat deraf.
4. Nukleosidanalog ifølge krav 1, hvor pyrimidin- eller purin-nukleinsyrebasen er uracil eller et derivat deraf.
5. Nukleosidanalog ifølge krav 1, hvor pyrimidin- eller purin-nukleinsyrebasen er cytosin eller et derivat deraf.
6. Nukleosidanalog ifølge krav 1, hvor pyrimidin- eller purin-nukleinsyrebasen er adenin eller et derivat deraf.
7. Nukleosidanalog ifølge krav 1, hvor pyrimidin- eller purin-nukleinsyrebasen er guanin eller et derivat deraf.
8. Nukleosidanalog ifølge et hvilket som helst af kravene 1-3 med den følgende generelle formel (li)
hvor B er en pyrimidin- eller purin-nukleinsyrebase, eller en analog deraf, og X og Y er identiske eller forskellige, og repræsenterer hver et hydrogenatom, en alkylgruppe, en alkenylgruppe, en alkynylgruppe, en cycloalkylgruppe, en arylgruppe, en acylgruppe, eller en silylgruppe, eller et amiditderivat deraf; hvor nævnte pyrimidin- eller purin-nukleinsyrebase er thymin.
9. Nukleosidanalog ifølge et hvilket som helst af kravene 1, 2 og 4 med den følgende generelle formel (Iii)
hvor B er en pyrimidin- eller purin-nukleinsyrebase, eller en analog deraf, og X og Y er identiske eller forskellige, og repræsenterer hver et hydrogenatom, en alkylgruppe, en alkenylgruppe, en alkynylgruppe, en cycloalkylgruppe, en arylgruppe, en acylgruppe, eller en silylgruppe, eller et amiditderivat deraf; hvor nævnte pyrimidin- eller purin-nukleinsyrebase er uracil.
10. Nukleosidanalog ifølge et hvilket som helst af kravene 1, 2 og 5 med den følgende generelle formel (liii) (llii) hvor B er en pyrimidin- eller purin-nukleinsyrebase, eller en analog deraf, og X og Y er identiske eller forskellige, og repræsenterer hver et hydrogenatom, en alkylgruppe, en alkenylgruppe, en alkynylgruppe, en cycloalkylgruppe, en arylgruppe, en acylgruppe, eller en silylgruppe, eller et amiditderivat deraf; hvor nævnte pyrimidin- eller purin-nukleinsyrebase er cytosin.
11. Nukleosidanalog ifølge et hvilket som helst af kravene 1, 2 og 6 med den følgende generelle formel (liv)
hvor B er en pyrimidin- eller purin-nukleinsyrebase, eller en analog deraf, og X og Y er identiske eller forskellige, og repræsenterer hver et hydrogenatom, en alkylgruppe, en alkenylgruppe, en alkynylgruppe, en cycloalkylgruppe, en arylgruppe, en acylgruppe, eller en silylgruppe, eller et amiditderivat deraf; hvor nævnte pyrimidin- eller purin-nukleinsyrebase er adenin.
12. Nukleosidanalog ifølge et hvilket som helst af kravene 1, 2 og 7 med den følgende generelle formel (Iv)
hvor B er en pyrimidin- eller purin-nukleinsyrebase, eller en analog deraf, og X og Y er identiske eller forskellige, og repræsenterer hver et hydrogenatom, en alkylgruppe, en alkenylgruppe, en alkynylgruppe, en cycloalkylgruppe, en arylgruppe, en acylgruppe, eller en silylgruppe, eller et amiditderivat deraf; hvor nævnte pyrimidin- eller purin-nukleinsyrebase er guanin.
13. Nukleosidanalog ifølge krav 1, hvor X og Y hver repræsenterer et hydrogenatom.
14. Nukleosid af den følgende generelle formel (I)
hvor B er en pyrimidin- eller purin-nukleinsyrebase, eller en analog deraf, som er et mononukleosidamidit-derivat, hvor X er 4,4-dimethoxytrityl (DMTr), og Y er en 2-cyanoethoxy(diisopropylamino)phosphinogruppe (amiditgruppe).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5340997 | 1997-03-07 | ||
PCT/JP1998/000945 WO1998039352A1 (fr) | 1997-03-07 | 1998-03-09 | Nouveaux analogues de bicyclonucleoside et d'oligonucleotide |
Publications (2)
Publication Number | Publication Date |
---|---|
DK1013661T3 DK1013661T3 (da) | 2012-03-19 |
DK1013661T4 true DK1013661T4 (da) | 2019-01-21 |
Family
ID=12942037
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK10011863.7T DK2361921T3 (da) | 1997-03-07 | 1998-03-09 | Bicyklooligonukleotidanaloger |
DK10172971.3T DK2295441T3 (da) | 1997-03-07 | 1998-03-09 | Bicyklonukleosidoligonukleotidanalog |
DK98905804.5T DK1013661T4 (da) | 1997-03-07 | 1998-03-09 | 2'-O,4'-C-methylen bicyklonukleosider |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK10011863.7T DK2361921T3 (da) | 1997-03-07 | 1998-03-09 | Bicyklooligonukleotidanaloger |
DK10172971.3T DK2295441T3 (da) | 1997-03-07 | 1998-03-09 | Bicyklonukleosidoligonukleotidanalog |
Country Status (12)
Country | Link |
---|---|
US (1) | US6268490B1 (da) |
EP (3) | EP2361921B1 (da) |
JP (1) | JP3756313B2 (da) |
AT (1) | ATE541576T2 (da) |
AU (1) | AU720472B2 (da) |
CA (1) | CA2283509C (da) |
DE (1) | DE98905804T1 (da) |
DK (3) | DK2361921T3 (da) |
ES (3) | ES2545211T3 (da) |
HK (1) | HK1154590A1 (da) |
PT (2) | PT2295441E (da) |
WO (1) | WO1998039352A1 (da) |
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- 1998-03-09 ES ES10011863.7T patent/ES2545211T3/es not_active Expired - Lifetime
- 1998-03-09 US US09/380,638 patent/US6268490B1/en not_active Ceased
- 1998-03-09 AT AT98905804T patent/ATE541576T2/de active
- 1998-03-09 PT PT101729713T patent/PT2295441E/pt unknown
- 1998-03-09 ES ES98905804T patent/ES2380354T5/es not_active Expired - Lifetime
- 1998-03-09 DK DK10011863.7T patent/DK2361921T3/da active
- 1998-03-09 WO PCT/JP1998/000945 patent/WO1998039352A1/ja active IP Right Grant
- 1998-03-09 DK DK10172971.3T patent/DK2295441T3/da active
- 1998-03-09 EP EP10172971.3A patent/EP2295441B1/en not_active Expired - Lifetime
- 1998-03-09 DK DK98905804.5T patent/DK1013661T4/da active
- 1998-03-09 DE DE98905804T patent/DE98905804T1/de active Pending
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- 1998-03-09 EP EP98905804.5A patent/EP1013661B2/en not_active Expired - Lifetime
- 1998-03-09 PT PT98905804T patent/PT1013661E/pt unknown
- 1998-03-09 ES ES10172971.3T patent/ES2485716T3/es not_active Expired - Lifetime
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US6268490B1 (en) | 2001-07-31 |
WO1998039352A1 (fr) | 1998-09-11 |
EP2361921A3 (en) | 2012-06-27 |
EP1013661A4 (en) | 2000-11-22 |
EP2361921B1 (en) | 2015-06-03 |
DE98905804T1 (de) | 2010-08-26 |
EP2295441A3 (en) | 2011-10-26 |
EP1013661A1 (en) | 2000-06-28 |
EP2295441B1 (en) | 2014-05-07 |
ES2380354T5 (es) | 2019-04-02 |
ATE541576T2 (de) | 2012-02-15 |
JP3756313B2 (ja) | 2006-03-15 |
CA2283509C (en) | 2005-01-04 |
ES2485716T3 (es) | 2014-08-14 |
EP1013661B1 (en) | 2012-01-18 |
CA2283509A1 (en) | 1998-09-11 |
HK1154590A1 (en) | 2012-04-27 |
PT2295441E (pt) | 2014-07-25 |
DK1013661T3 (da) | 2012-03-19 |
JPH10304889A (ja) | 1998-11-17 |
EP2361921A2 (en) | 2011-08-31 |
ES2545211T3 (es) | 2015-09-09 |
EP2295441A2 (en) | 2011-03-16 |
EP1013661B2 (en) | 2018-10-24 |
AU6120998A (en) | 1998-09-22 |
AU720472B2 (en) | 2000-06-01 |
DK2295441T3 (da) | 2014-07-21 |
PT1013661E (pt) | 2012-03-28 |
DK2361921T3 (da) | 2015-09-14 |
ES2380354T3 (es) | 2012-05-10 |
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