US7119184B2
(en)
*
|
1991-08-12 |
2006-10-10 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having A-DNA form and B-DNA form conformational geometry
|
US5898031A
(en)
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
US9096636B2
(en)
|
1996-06-06 |
2015-08-04 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds and their use in gene modulation
|
US7812149B2
(en)
|
1996-06-06 |
2010-10-12 |
Isis Pharmaceuticals, Inc. |
2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
|
JP3756313B2
(ja)
†
|
1997-03-07 |
2006-03-15 |
武 今西 |
新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
|
US6770748B2
(en)
|
1997-03-07 |
2004-08-03 |
Takeshi Imanishi |
Bicyclonucleoside and oligonucleotide analogue
|
USRE44779E1
(en)
|
1997-03-07 |
2014-02-25 |
Santaris Pharma A/S |
Bicyclonucleoside and oligonucleotide analogues
|
US7572582B2
(en)
|
1997-09-12 |
2009-08-11 |
Exiqon A/S |
Oligonucleotide analogues
|
US6794499B2
(en)
|
1997-09-12 |
2004-09-21 |
Exiqon A/S |
Oligonucleotide analogues
|
EP2341057A3
(en)
*
|
1997-09-12 |
2011-11-23 |
Exiqon A/S |
Oligonucleotide Analogues
|
US6583168B1
(en)
|
1997-11-25 |
2003-06-24 |
Applera Corporation |
Sulfonated diarylrhodamine dyes
|
JP4148662B2
(ja)
*
|
2000-08-10 |
2008-09-10 |
第一三共株式会社 |
ヌクレオシド及びオリゴヌクレオチド類縁体を含有する核酸試薬及び医薬
|
AU758956B2
(en)
|
1999-02-12 |
2003-04-03 |
Daiichi Sankyo Company, Limited |
Novel nucleosides and oligonucleotide analogues
|
ATE465168T1
(de)
*
|
1999-03-18 |
2010-05-15 |
Exiqon As |
Xylo-lna analoge
|
US7084125B2
(en)
|
1999-03-18 |
2006-08-01 |
Exiqon A/S |
Xylo-LNA analogues
|
CN1361829A
(zh)
|
1999-03-18 |
2002-07-31 |
埃克西库恩公司 |
利用特异性lna引物检测基因突变
|
US6436640B1
(en)
*
|
1999-03-18 |
2002-08-20 |
Exiqon A/S |
Use of LNA in mass spectrometry
|
ATE314488T1
(de)
|
1999-03-18 |
2006-01-15 |
Exiqon As |
Einstufige probezubereitung und bestimmung von nukleinsäure in biologischen proben
|
US6734291B2
(en)
*
|
1999-03-24 |
2004-05-11 |
Exiqon A/S |
Synthesis of [2.2.1]bicyclo nucleosides
|
WO2000056746A2
(en)
*
|
1999-03-24 |
2000-09-28 |
Exiqon A/S |
Improved synthesis of [2.2.1]bicyclo nucleosides
|
US7098192B2
(en)
|
1999-04-08 |
2006-08-29 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of STAT3 expression
|
EP1178999B1
(en)
*
|
1999-05-04 |
2007-03-14 |
Santaris Pharma A/S |
L-ribo-lna analogues
|
JP4151751B2
(ja)
*
|
1999-07-22 |
2008-09-17 |
第一三共株式会社 |
新規ビシクロヌクレオシド類縁体
|
AU3041701A
(en)
*
|
1999-12-23 |
2001-07-09 |
Exiqon A/S |
Therapeutic uses of lna-modified oligonucleotides
|
US6887664B2
(en)
|
2000-06-06 |
2005-05-03 |
Applera Corporation |
Asynchronous primed PCR
|
AU2001271042A1
(en)
*
|
2000-07-19 |
2002-01-30 |
Chugai Seiyaku Kabushiki Kaisha |
Novel antisense oligonucleotide derivatives against wilms's tumor gene
|
JP2002322192A
(ja)
*
|
2000-08-10 |
2002-11-08 |
Sankyo Co Ltd |
2’−o,4’−c−架橋ヌクレオシドトリリン酸体
|
EP1314734A1
(en)
*
|
2000-08-29 |
2003-05-28 |
Takeshi Imanishi |
Novel nucleoside analogs and oligonucleotide derivatives containing these analogs
|
EP1334109B1
(en)
|
2000-10-04 |
2006-05-10 |
Santaris Pharma A/S |
Improved synthesis of purine locked nucleic acid analogues
|
EP1414840A4
(en)
|
2001-03-27 |
2005-04-13 |
Univ Delaware |
GENOMIC APPLICATIONS FOR MODIFIED OLIGONUCLEOTIDES
|
EP1251183A3
(en)
*
|
2001-04-18 |
2003-12-10 |
Exiqon A/S |
Improved helper probes for detection of a target sequence by a capture oligonucleotide
|
PT2000545E
(pt)
|
2001-06-20 |
2011-12-21 |
Genentech Inc |
Composições e métodos para o diagnóstico e tratamento do tumor pulmonar
|
EP2270024B1
(en)
|
2001-06-21 |
2018-10-24 |
Ionis Pharmaceuticals, Inc. |
Antisense modulation of superoxide dismutase 1, soluble expression
|
US6822088B2
(en)
|
2001-07-17 |
2004-11-23 |
Isis Pharmaceuticals, Inc. |
Synthesis of oligonucleotides on solid support
|
AU2002365115A1
(en)
|
2001-07-20 |
2003-09-02 |
North Carolina State University |
Light addressable electrochemical detection of duplex structures
|
US6964950B2
(en)
|
2001-07-25 |
2005-11-15 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of C-reactive protein expression
|
US7425545B2
(en)
|
2001-07-25 |
2008-09-16 |
Isis Pharmaceuticals, Inc. |
Modulation of C-reactive protein expression
|
US20030096772A1
(en)
|
2001-07-30 |
2003-05-22 |
Crooke Rosanne M. |
Antisense modulation of acyl CoA cholesterol acyltransferase-2 expression
|
US7407943B2
(en)
|
2001-08-01 |
2008-08-05 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of apolipoprotein B expression
|
US7227014B2
(en)
|
2001-08-07 |
2007-06-05 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of apolipoprotein (a) expression
|
US20040096880A1
(en)
*
|
2001-08-07 |
2004-05-20 |
Kmiec Eric B. |
Compositions and methods for the treatment of diseases exhibiting protein misassembly and aggregation
|
EP1437408A4
(en)
*
|
2001-09-17 |
2006-08-23 |
Takeshi Imanishi |
NOVEL ANTISENSE OLIGONUCLEOTIDE DERIVATIVES AGAINST HEPATITIS C VIRUS
|
NZ573831A
(en)
|
2001-09-18 |
2010-07-30 |
Genentech Inc |
Compositions and methods for the diagnosis and treatment of tumor, particularly breast tumor - TAT193
|
WO2003027264A2
(en)
*
|
2001-09-27 |
2003-04-03 |
University Of Delaware |
Coisogenic eukaryotic cell collections
|
US7468244B2
(en)
*
|
2001-09-27 |
2008-12-23 |
University Of Delaware |
Polymorphism detection and separation
|
US6750019B2
(en)
|
2001-10-09 |
2004-06-15 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of insulin-like growth factor binding protein 5 expression
|
ATE516364T1
(de)
|
2001-10-09 |
2011-07-15 |
Isis Pharmaceuticals Inc |
Antisense-modulation der expression des insulinähnlicher-wachstumsfaktor-bindungsprotei s 5
|
WO2003033696A1
(fr)
*
|
2001-10-18 |
2003-04-24 |
Sankyo Company, Limited |
Compose antisens vegf
|
AU2002347981A1
(en)
*
|
2001-11-07 |
2003-05-19 |
Applera Corporation |
Universal nucleotides for nucleic acid analysis
|
JP2005517900A
(ja)
|
2001-11-21 |
2005-06-16 |
アプレラ コーポレイション |
デジタルアッセイ
|
US6965025B2
(en)
|
2001-12-10 |
2005-11-15 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of connective tissue growth factor expression
|
US20030198980A1
(en)
*
|
2001-12-21 |
2003-10-23 |
Applera Corporation |
Heteroconfigurational polynucleotides and methods of use
|
CA2471431A1
(en)
|
2002-01-02 |
2003-07-17 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of tumor
|
US20030166282A1
(en)
*
|
2002-02-01 |
2003-09-04 |
David Brown |
High potency siRNAS for reducing the expression of target genes
|
CA2474910A1
(en)
|
2002-02-01 |
2003-08-07 |
Sequitur, Inc. |
Oligonucleotide compositions with enhanced efficiency
|
US20060009409A1
(en)
|
2002-02-01 |
2006-01-12 |
Woolf Tod M |
Double-stranded oligonucleotides
|
DK2354148T3
(da)
|
2002-02-13 |
2013-10-14 |
Takeshi Imanishi |
Nukleosidanaloger og oligonukleotiderivate omfattende nukleotidanalog deraf
|
US7566535B2
(en)
|
2002-03-07 |
2009-07-28 |
University Of Delaware |
Enhanced oligonucleotide-mediated nucleic acid sequence alteration
|
US20030198960A1
(en)
*
|
2002-04-01 |
2003-10-23 |
Wenhong Fan |
Signal amplifying targeted reporters for biological and chemical sensor applications
|
US7211382B2
(en)
*
|
2002-04-09 |
2007-05-01 |
Orchid Cellmark Inc. |
Primer extension using modified nucleotides
|
NZ535925A
(en)
|
2002-04-16 |
2008-06-30 |
Genentech Inc |
An isolated antibody that binds to a particular polypeptide
|
US7569575B2
(en)
|
2002-05-08 |
2009-08-04 |
Santaris Pharma A/S |
Synthesis of locked nucleic acid derivatives
|
US7199107B2
(en)
|
2002-05-23 |
2007-04-03 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of kinesin-like 1 expression
|
EP1532271A4
(en)
*
|
2002-06-12 |
2006-10-18 |
Ambion Inc |
METHODS AND COMPOSITIONS RELATED TO POLYPEPTIDES WITH RNASE III DOMAINS THAT TRANSFER RNA INTERFERENCE
|
US20040248094A1
(en)
*
|
2002-06-12 |
2004-12-09 |
Ford Lance P. |
Methods and compositions relating to labeled RNA molecules that reduce gene expression
|
US20100075423A1
(en)
*
|
2002-06-12 |
2010-03-25 |
Life Technologies Corporation |
Methods and compositions relating to polypeptides with rnase iii domains that mediate rna interference
|
US7005265B1
(en)
|
2002-06-20 |
2006-02-28 |
Wenhong Fan |
Nonenzymatic catalytic signal amplification for nucleic acid hybridization assays
|
BR0314236A
(pt)
|
2002-09-13 |
2005-08-09 |
Replicor Inc |
Formulação de oligonucleotìdeo, composição farmacêutica, kit, composto antiviral, preparação de oligonucleotìdeo e métodos para seleção de um oligonucleotìdeo antiviral para uso como um agente antiviral, para profilaxia ou tratamento de uma infecção viral em um paciente, para tratamento profilático de câncer causado por oncovìrus, para identificação de um composto que altera a ligação de um oligonucleotìdeo a pelo menos um componente viral, para purificação da ligação de oligonucleotìdeos a pelo menos um componente viral e para enriquecimento de oligonucleotìdeos a partir de um agrupamento de oligonucleotìdeos
|
WO2004031350A2
(en)
|
2002-09-26 |
2004-04-15 |
Amgen, Inc. |
Modulation of forkhead box o1a expression
|
WO2004033708A2
(en)
*
|
2002-10-07 |
2004-04-22 |
University Of Delaware |
Methods and compositions for reducing screening in oligonucleotide-directed nucleic acid sequence alteration
|
US20040219565A1
(en)
|
2002-10-21 |
2004-11-04 |
Sakari Kauppinen |
Oligonucleotides useful for detecting and analyzing nucleic acids of interest
|
WO2004041889A2
(en)
|
2002-11-05 |
2004-05-21 |
Isis Pharmaceuticals, Inc. |
Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
|
WO2004044136A2
(en)
|
2002-11-05 |
2004-05-27 |
Isis Pharmaceuticals, Inc. |
Compositions comprising alternating 2’-modified nucleosides for use in gene modulation
|
ES2417879T3
(es)
|
2002-11-13 |
2013-08-09 |
Genzyme Corporation |
Modulación antisentido de la expresión de la apolipoproteína B
|
EP2336318B1
(en)
|
2002-11-13 |
2013-04-24 |
Genzyme Corporation |
Antisense modulation of apolipoprotein b expression
|
AU2003281969B2
(en)
|
2002-11-18 |
2011-01-27 |
Roche Innovation Center Copenhagen A/S |
Amino-LNA, thio-LNA and alpha-L-oxy-LN
|
TWI347948B
(en)
|
2002-11-19 |
2011-09-01 |
Sankyo Co |
Novel 2',5'-oligoadenylic acid compositions
|
JP5132025B2
(ja)
*
|
2002-11-19 |
2013-01-30 |
第一三共株式会社 |
新規2’,5’−オリゴアデニル酸類縁体
|
US7144999B2
(en)
|
2002-11-23 |
2006-12-05 |
Isis Pharmaceuticals, Inc. |
Modulation of hypoxia-inducible factor 1 alpha expression
|
ES2400033T3
(es)
|
2003-02-11 |
2013-04-05 |
Antisense Therapeutics Ltd |
Modulación de la expresión del receptor del factor de crecimiento I similar a la insulina
|
US7803781B2
(en)
|
2003-02-28 |
2010-09-28 |
Isis Pharmaceuticals, Inc. |
Modulation of growth hormone receptor expression and insulin-like growth factor expression
|
US20040185559A1
(en)
|
2003-03-21 |
2004-09-23 |
Isis Pharmaceuticals Inc. |
Modulation of diacylglycerol acyltransferase 1 expression
|
AU2003237792A1
(en)
|
2003-04-01 |
2004-11-23 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of tumor
|
US7598227B2
(en)
|
2003-04-16 |
2009-10-06 |
Isis Pharmaceuticals Inc. |
Modulation of apolipoprotein C-III expression
|
US7399853B2
(en)
|
2003-04-28 |
2008-07-15 |
Isis Pharmaceuticals |
Modulation of glucagon receptor expression
|
WO2005031005A2
(en)
|
2003-05-19 |
2005-04-07 |
Gen-Probe Incorporated |
Compositions, methods and kits for determining the presence of trichomonas vaginalis in a test sample
|
CN1984921B
(zh)
|
2003-06-03 |
2010-06-16 |
Isis药物公司 |
存活蛋白表达的调节
|
ES2385828T3
(es)
*
|
2003-06-20 |
2012-08-01 |
Exiqon A/S |
Sondas, bibliotecas y kits para análisis de mezclas de ácidos nucleicos y procedimientos para construirlos
|
WO2005013901A2
(en)
|
2003-07-31 |
2005-02-17 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and compositions for use in modulation of small non-coding rnas
|
US7825235B2
(en)
|
2003-08-18 |
2010-11-02 |
Isis Pharmaceuticals, Inc. |
Modulation of diacylglycerol acyltransferase 2 expression
|
US20050053981A1
(en)
*
|
2003-09-09 |
2005-03-10 |
Swayze Eric E. |
Gapped oligomeric compounds having linked bicyclic sugar moieties at the termini
|
TW200519202A
(en)
|
2003-09-18 |
2005-06-16 |
Lilly Co Eli |
Modulation of eIF4E expression
|
US20050191653A1
(en)
|
2003-11-03 |
2005-09-01 |
Freier Susan M. |
Modulation of SGLT2 expression
|
ES2313104T3
(es)
|
2003-11-07 |
2009-03-01 |
Daiichi Sankyo Company, Limited |
Metodo para detectar polimorfismo genico.
|
DK2161283T3
(da)
|
2003-11-17 |
2014-09-01 |
Genentech Inc |
SAMMENSÆTNINGER OMFATTENDE ANTISTOFFER MOD CD79b, SOM ER KONJUGERET TIL ET VÆKSTINHIBERENDE MIDDEL ELLER ET CYTOTOKSISK MIDDEL, OG FREMGANGSMÅDER TIL BEHANDLING AF TUMOR AF HÆMATOPOIETISK OPRINDELSE
|
DE602004018732D1
(de)
|
2003-11-20 |
2009-02-12 |
Exiqon As |
Löscher-Zusammensetzung mit Anthraquinon
|
US7972783B2
(en)
*
|
2003-11-24 |
2011-07-05 |
Branhaven LLC |
Method and markers for determining the genotype of horned/polled cattle
|
WO2005071080A2
(en)
|
2004-01-20 |
2005-08-04 |
Isis Pharmaceuticals, Inc. |
Modulation of glucocorticoid receptor expression
|
US8569474B2
(en)
|
2004-03-09 |
2013-10-29 |
Isis Pharmaceuticals, Inc. |
Double stranded constructs comprising one or more short strands hybridized to a longer strand
|
EP1730309B1
(en)
|
2004-03-15 |
2016-05-04 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for optimizing cleavage of rna by rnase h
|
US8192937B2
(en)
*
|
2004-04-07 |
2012-06-05 |
Exiqon A/S |
Methods for quantification of microRNAs and small interfering RNAs
|
US8394947B2
(en)
|
2004-06-03 |
2013-03-12 |
Isis Pharmaceuticals, Inc. |
Positionally modified siRNA constructs
|
US7713697B2
(en)
*
|
2004-08-27 |
2010-05-11 |
Gen-Probe Incorporated |
Methods and kits for amplifying DNA
|
WO2006026388A2
(en)
|
2004-08-27 |
2006-03-09 |
Gen-Probe Incorporated |
Single-primer nucleic acid amplification methods
|
US7884086B2
(en)
|
2004-09-08 |
2011-02-08 |
Isis Pharmaceuticals, Inc. |
Conjugates for use in hepatocyte free uptake assays
|
US20060073506A1
(en)
|
2004-09-17 |
2006-04-06 |
Affymetrix, Inc. |
Methods for identifying biological samples
|
US20060073511A1
(en)
|
2004-10-05 |
2006-04-06 |
Affymetrix, Inc. |
Methods for amplifying and analyzing nucleic acids
|
US7682782B2
(en)
|
2004-10-29 |
2010-03-23 |
Affymetrix, Inc. |
System, method, and product for multiple wavelength detection using single source excitation
|
WO2006059507A1
(ja)
*
|
2004-11-30 |
2006-06-08 |
Sankyo Company, Limited |
11β-HSD1アンチセンス化合物
|
US20060166238A1
(en)
*
|
2004-12-22 |
2006-07-27 |
Ramsing Niels B |
Probes, libraries and kits for analysis of mixtures of nucleic acids and methods for constructing the same
|
US20060142228A1
(en)
*
|
2004-12-23 |
2006-06-29 |
Ambion, Inc. |
Methods and compositions concerning siRNA's as mediators of RNA interference
|
EP1959012A3
(en)
*
|
2004-12-29 |
2009-12-30 |
Exiqon A/S |
Novel oligonucleotide compositions and probe sequences useful for detection and analysis of microRNAs and their target mRNAs
|
EP2208796B1
(en)
|
2005-01-06 |
2014-06-18 |
Applied Biosystems, LLC |
Polypeptides having nucleic acid binding activity and compositions and methods for nucleic acid amplification
|
WO2006084132A2
(en)
|
2005-02-01 |
2006-08-10 |
Agencourt Bioscience Corp. |
Reagents, methods, and libraries for bead-based squencing
|
EP2233582A1
(en)
|
2005-02-01 |
2010-09-29 |
AB Advanced Genetic Analysis Corporation |
Nucleic acid sequencing by performing successive cycles of duplex extension
|
ZA200707490B
(en)
|
2005-03-10 |
2008-12-31 |
Genentech Inc |
Methods and compositions for modulatiing vascular integrity
|
US20070065840A1
(en)
*
|
2005-03-23 |
2007-03-22 |
Irena Naguibneva |
Novel oligonucleotide compositions and probe sequences useful for detection and analysis of microRNAS and their target mRNAS
|
WO2006138145A1
(en)
|
2005-06-14 |
2006-12-28 |
Northwestern University |
Nucleic acid functionalized nanoparticles for therapeutic applications
|
EP1910549B1
(en)
|
2005-07-15 |
2010-11-24 |
Life Technologies Corporation |
Analyzing messenger rna and micro rna in the same reaction mixture
|
US20070128620A1
(en)
|
2005-07-15 |
2007-06-07 |
Applera Corporation |
Hot start reverse transcription by primer design
|
AU2006281569A1
(en)
|
2005-08-17 |
2007-02-22 |
Medexis S.A. |
Composition and method for determination of CK19 expression
|
EP1931780B1
(en)
|
2005-08-29 |
2016-01-06 |
Regulus Therapeutics Inc. |
Antisense compounds having enhanced anti-microrna activity
|
JP5523705B2
(ja)
|
2005-08-29 |
2014-06-18 |
レグルス・セラピューティクス・インコーポレイテッド |
Mir−122aをモジュレートする使用方法
|
JP4741328B2
(ja)
*
|
2005-09-08 |
2011-08-03 |
クラリオン株式会社 |
ナビゲーション装置
|
US20070059713A1
(en)
|
2005-09-09 |
2007-03-15 |
Lee Jun E |
SSB-DNA polymerase fusion proteins
|
CN103215248B
(zh)
|
2005-10-03 |
2016-05-18 |
应用生物系统有限责任公司 |
用于扩增核酸的组合物、方法和试剂盒
|
EP1960536B1
(en)
|
2005-11-30 |
2013-06-26 |
St. Anna Kinderkrebsforschung |
Detection of fungi
|
JP5623016B2
(ja)
|
2005-12-01 |
2014-11-12 |
プロネイ・セラピューティクス・インコーポレイテッドPronaitherapeutics, Inc. |
癌治療法およびそれに用いる医薬組成物
|
WO2007073149A1
(en)
|
2005-12-22 |
2007-06-28 |
Keygene N.V. |
Alternative nucleotides for improved targeted nucleotide exchange
|
WO2007087113A2
(en)
|
2005-12-28 |
2007-08-02 |
The Scripps Research Institute |
Natural antisense and non-coding rna transcripts as drug targets
|
WO2007073737A1
(en)
*
|
2005-12-29 |
2007-07-05 |
Exiqon A/S |
Detection of tissue origin of cancer
|
JP5425474B2
(ja)
|
2006-01-26 |
2014-02-26 |
アイシス ファーマシューティカルズ, インコーポレーテッド |
ハンチンチン対する、組成物及びその使用
|
CA2640171C
(en)
*
|
2006-01-27 |
2014-10-28 |
Isis Pharmaceuticals, Inc. |
6-modified bicyclic nucleic acid analogs
|
CA2640058C
(en)
|
2006-01-27 |
2018-04-24 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and compositions for the use in modulation of micrornas
|
WO2007106690A2
(en)
|
2006-03-15 |
2007-09-20 |
Siemens Healthcare Diagnostics Inc. |
Degenerate nucleobase analogs
|
US20090062129A1
(en)
*
|
2006-04-19 |
2009-03-05 |
Agencourt Personal Genomics, Inc. |
Reagents, methods, and libraries for gel-free bead-based sequencing
|
EP2021511A4
(en)
|
2006-05-03 |
2010-02-10 |
Geisinger Clinic |
METHODS OF DIAGNOSIS AND PREDICTION OF NON ALCOHOLIC STHEATHYPATITIS (NASH)
|
AU2007258117B2
(en)
|
2006-05-05 |
2013-05-30 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating gene expression
|
EP2527442A3
(en)
|
2006-05-05 |
2013-03-06 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating gene expression
|
US7666854B2
(en)
*
|
2006-05-11 |
2010-02-23 |
Isis Pharmaceuticals, Inc. |
Bis-modified bicyclic nucleic acid analogs
|
ES2389737T3
(es)
*
|
2006-05-11 |
2012-10-31 |
Isis Pharmaceuticals, Inc. |
Análogos de ácidos nucleicos bicíclicos modificados en 5'
|
US20090023221A1
(en)
*
|
2006-05-19 |
2009-01-22 |
Exigon A/S |
Oligonucleotide probes useful for detection and analysis of microrna precursors
|
ATE496144T1
(de)
|
2006-06-06 |
2011-02-15 |
Gen Probe Inc |
Markierte oligonukleotide und ihre verwendung in nukleinsäureverstärkungsverfahren
|
US20080076674A1
(en)
*
|
2006-07-06 |
2008-03-27 |
Thomas Litman |
Novel oligonucleotide compositions and probe sequences useful for detection and analysis of non coding RNAs associated with cancer
|
US8198253B2
(en)
|
2006-07-19 |
2012-06-12 |
Isis Pharmaceuticals, Inc. |
Compositions and their uses directed to HBXIP
|
EP2484781B1
(en)
|
2006-08-01 |
2017-08-23 |
Applied Biosystems, LLC |
Detection of analytes and nucleic acids
|
AU2007284651B2
(en)
|
2006-08-09 |
2014-03-20 |
Institute For Systems Biology |
Organ-specific proteins and methods of their use
|
US7947487B2
(en)
|
2006-10-05 |
2011-05-24 |
Massachusetts Institute Of Technology |
Multifunctional encoded particles for high-throughput analysis
|
US9074205B2
(en)
*
|
2006-10-18 |
2015-07-07 |
Marina Biotech, Inc. |
Nicked or gapped nucleic acid molecules and uses thereof
|
US9550988B2
(en)
|
2006-10-18 |
2017-01-24 |
Ionis Pharmaceuticals, Inc. |
Antisense compounds
|
WO2008046911A2
(en)
|
2006-10-20 |
2008-04-24 |
Exiqon A/S |
Novel human micrornas associated with cancer
|
US8188255B2
(en)
*
|
2006-10-20 |
2012-05-29 |
Exiqon A/S |
Human microRNAs associated with cancer
|
US8093222B2
(en)
|
2006-11-27 |
2012-01-10 |
Isis Pharmaceuticals, Inc. |
Methods for treating hypercholesterolemia
|
EP2455471A3
(en)
|
2006-11-27 |
2012-09-12 |
Isis Pharmaceuticals, Inc. |
Methods for treating hypercholesterolemia
|
US8293684B2
(en)
|
2006-11-29 |
2012-10-23 |
Exiqon |
Locked nucleic acid reagents for labelling nucleic acids
|
EP2113567B1
(en)
|
2006-12-21 |
2019-04-03 |
QIAGEN GmbH |
MicroRNA target site blocking oligos and uses thereof
|
US8048998B2
(en)
*
|
2007-01-19 |
2011-11-01 |
Exiqon A/S |
Mediated cellular delivery of LNA oligonucleotides
|
MX2009008470A
(es)
|
2007-02-09 |
2009-11-26 |
Univ Northwestern |
Particulas para detectar objetivos intracelulares.
|
WO2008104978A2
(en)
*
|
2007-02-28 |
2008-09-04 |
Quark Pharmaceuticals, Inc. |
Novel sirna structures
|
US8183359B2
(en)
*
|
2007-03-01 |
2012-05-22 |
Gen-Probe Incorporated |
Kits for amplifying DNA
|
US20100105134A1
(en)
*
|
2007-03-02 |
2010-04-29 |
Mdrna, Inc. |
Nucleic acid compounds for inhibiting gene expression and uses thereof
|
WO2008109357A1
(en)
*
|
2007-03-02 |
2008-09-12 |
Mdrna, Inc. |
Nucleic acid compounds for inhibiting apob gene expression and uses thereof
|
WO2008109362A1
(en)
*
|
2007-03-02 |
2008-09-12 |
Mdrna, Inc. |
Nucleic acid compounds for inhibiting vegf gene expression and uses thereof
|
US20100055784A1
(en)
*
|
2007-03-02 |
2010-03-04 |
Mdrna, Inc. |
Nucleic acid compounds for inhibiting wnt gene expression and uses thereof
|
WO2008109377A1
(en)
*
|
2007-03-02 |
2008-09-12 |
Mdrna, Inc. |
Nucleic acid compounds for inhibiting vegf family gene expression and uses thereof
|
JP2010519910A
(ja)
*
|
2007-03-02 |
2010-06-10 |
エムディーアールエヌエー,インコーポレイテッド |
Bcl2遺伝子の発現を抑制するための核酸化合物およびその使用
|
US20100055782A1
(en)
*
|
2007-03-02 |
2010-03-04 |
Mdrna, Inc. |
Nucleic acid compounds for inhibiting myc gene expression and uses thereof
|
WO2008109361A1
(en)
*
|
2007-03-02 |
2008-09-12 |
Mdrna, Inc, |
Nucleic acid compounds for inhibiting erbb family gene expression and uses thereof
|
JP2010519905A
(ja)
*
|
2007-03-02 |
2010-06-10 |
エムディーアールエヌエー,インコーポレイテッド |
Akt遺伝子の発現を抑制するための核酸化合物およびその使用
|
JP2010519908A
(ja)
*
|
2007-03-02 |
2010-06-10 |
エムディーアールエヌエー,インコーポレイテッド |
Hif1a遺伝子の発現を抑制するための核酸化合物およびその使用
|
KR20100051041A
(ko)
*
|
2007-03-07 |
2010-05-14 |
엔벤타 바이오파마슈티칼스 코퍼레이션 |
이중-가닥 봉쇄형 핵산 조성물
|
US8461124B2
(en)
*
|
2007-03-15 |
2013-06-11 |
Jyoti Chattopadhyaya |
Five- and six-membered conformationally locked 2′,4′-carbocyclic ribo-thymidines for the treatment of infections and cancer
|
EP1978111B1
(en)
|
2007-04-02 |
2013-03-27 |
Gen-Probe Incorporated |
Compositions, kits and related methods for the detection and/or monitoring of Pseudomonas aeruginosa
|
FR2915208A1
(fr)
|
2007-04-20 |
2008-10-24 |
Millipore Corp |
Composition comprenant l'association d'edta et de pei pour augmenter la permeabilite des parois des microorganismes et utilisations de ladite composition
|
US8999634B2
(en)
|
2007-04-27 |
2015-04-07 |
Quest Diagnostics Investments Incorporated |
Nucleic acid detection combining amplification with fragmentation
|
WO2008150729A2
(en)
|
2007-05-30 |
2008-12-11 |
Isis Pharmaceuticals, Inc. |
N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
|
DK2826863T3
(en)
|
2007-05-30 |
2017-12-04 |
Univ Northwestern |
NUCLEIC ACID FUNCTIONALIZED NANOPARTICLES FOR THERAPEUTIC APPLICATIONS
|
US9598724B2
(en)
|
2007-06-01 |
2017-03-21 |
Ibis Biosciences, Inc. |
Methods and compositions for multiple displacement amplification of nucleic acids
|
US7807372B2
(en)
|
2007-06-04 |
2010-10-05 |
Northwestern University |
Screening sequence selectivity of oligonucleotide-binding molecules using nanoparticle based colorimetric assay
|
EP2173760B2
(en)
|
2007-06-08 |
2015-11-04 |
Isis Pharmaceuticals, Inc. |
Carbocyclic bicyclic nucleic acid analogs
|
US20100261175A1
(en)
*
|
2007-06-15 |
2010-10-14 |
Exiqon A/S |
Use of short oligonucleotides for reagent redundancy experiments in rna functional analysis
|
US8278283B2
(en)
*
|
2007-07-05 |
2012-10-02 |
Isis Pharmaceuticals, Inc. |
6-disubstituted or unsaturated bicyclic nucleic acid analogs
|
WO2009039173A2
(en)
|
2007-09-19 |
2009-03-26 |
Applied Biosystems Inc. |
SiRNA SEQUENCE-INDEPENDENT MODIFICATION FORMATS FOR REDUCING OFF-TARGET PHENOTYPIC EFFECTS IN RNAi, AND STABILIZED FORMS THEREOF
|
MX2010003465A
(es)
|
2007-10-02 |
2010-07-05 |
Amgen Inc |
Incremento de eritropoyetina utilizando acidos nucleicos que hibridan para micro-arn y precursores de los mismos.
|
WO2009044392A2
(en)
|
2007-10-03 |
2009-04-09 |
Quark Pharmaceuticals, Inc. |
Novel sirna structures
|
US9211537B2
(en)
*
|
2007-11-07 |
2015-12-15 |
The University Of British Columbia |
Microfluidic device and method of using same
|
WO2009067632A1
(en)
*
|
2007-11-20 |
2009-05-28 |
Applied Biosystems Inc. |
Method of sequencing nucleic acids using elaborated nucleotide phosphorothiolate compounds
|
US8017338B2
(en)
|
2007-11-20 |
2011-09-13 |
Life Technologies Corporation |
Reversible di-nucleotide terminator sequencing
|
WO2009067647A1
(en)
*
|
2007-11-21 |
2009-05-28 |
Isis Pharmaceuticals, Inc. |
Carbocyclic alpha-l-bicyclic nucleic acid analogs
|
EP4053546A1
(en)
|
2007-12-06 |
2022-09-07 |
Genalyte, Inc. |
Device and method for performing label-free monitoring of processes.
|
US8614311B2
(en)
|
2007-12-12 |
2013-12-24 |
Quark Pharmaceuticals, Inc. |
RTP801L siRNA compounds and methods of use thereof
|
US20110105584A1
(en)
*
|
2007-12-12 |
2011-05-05 |
Elena Feinstein |
Rtp80il sirna compounds and methods of use thereof
|
WO2009086218A2
(en)
|
2007-12-21 |
2009-07-09 |
Gen-Probe Incorporated |
Detection of antibiotic-resistant microorganisms
|
EP2242854A4
(en)
*
|
2008-01-15 |
2012-08-15 |
Quark Pharmaceuticals Inc |
COMPOUNDS AND USES THEREOF
|
EP2246422A4
(en)
*
|
2008-01-24 |
2012-07-25 |
Nat Inst Of Advanced Ind Scien |
POLYNUCLEOTIDE OR ITS ANALOGUE, AND METHOD OF REGULATING GENE EXPRESSION USING THE POLYNUCLEOTIDE OR ITS ANALOGUE
|
EP2265627A2
(en)
*
|
2008-02-07 |
2010-12-29 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexitol nucleic acid analogs
|
US20090215050A1
(en)
*
|
2008-02-22 |
2009-08-27 |
Robert Delmar Jenison |
Systems and methods for point-of-care amplification and detection of polynucleotides
|
BRPI0909270A2
(pt)
*
|
2008-03-20 |
2015-08-11 |
Quark Pharmaceuticals Inc |
Compostos de sirna para inibição de rtp801
|
US9290534B2
(en)
*
|
2008-04-04 |
2016-03-22 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds having at least one neutrally linked terminal bicyclic nucleoside
|
US20100113284A1
(en)
*
|
2008-04-04 |
2010-05-06 |
Alexander Aristarkhov |
Small interfering rna (sirna) target site blocking oligos and uses thereof
|
US8846639B2
(en)
*
|
2008-04-04 |
2014-09-30 |
Isis Pharmaceutical, Inc. |
Oligomeric compounds comprising bicyclic nucleosides and having reduced toxicity
|
US20090326049A1
(en)
*
|
2008-04-04 |
2009-12-31 |
Alexander Aristarkhov |
Blocking oligos for inhibition of microrna and sirna activity and uses thereof
|
WO2009144704A2
(en)
*
|
2008-04-15 |
2009-12-03 |
Quark Pharmaceuticals, Inc. |
siRNA COMPOUNDS FOR INHIBITING NRF2
|
PL2982753T3
(pl)
|
2008-04-18 |
2019-03-29 |
Baxter International Inc. |
Kompozycja na bazie mikrosfer do zapobiegania i/lub cofania nowego przypadku cukrzycy autoimmunologicznej
|
EP2288726B1
(en)
|
2008-05-13 |
2012-06-13 |
Gen-Probe Incorporated |
Inactivatable target capture oligomers for use in the selective hybridization and capture of target nucleic acid sequences
|
JP2011521651A
(ja)
|
2008-05-30 |
2011-07-28 |
ジェン−プロウブ インコーポレイテッド |
サルモネラの検出および/またはモニタリングのための組成物、キットおよび関連方法
|
US8222221B2
(en)
|
2008-06-04 |
2012-07-17 |
The Board Of Regents Of The University Of Texas System |
Modulation of gene expression through endogenous small RNA targeting of gene promoters
|
US8431692B2
(en)
|
2008-06-06 |
2013-04-30 |
Quark Pharmaceuticals, Inc. |
Compositions and methods for treatment of ear disorders
|
AU2009276763B2
(en)
|
2008-07-29 |
2015-07-16 |
The Board Of Regents Of The University Of Texas Sytem |
Selective inhibition of polyglutamine protein expression
|
WO2010027832A1
(en)
|
2008-08-25 |
2010-03-11 |
Excaliard Pharmaceuticals, Inc. |
Method for reducing scarring during wound healing using antisense compounds directed to ctgf
|
DK2331141T3
(en)
|
2008-08-25 |
2016-04-04 |
Excaliard Pharmaceuticals Inc |
Antisense oligonucleotides WHO IS TARGETING connective tissue, AND USES THEREOF
|
JP5221248B2
(ja)
*
|
2008-08-26 |
2013-06-26 |
株式会社日立ハイテクノロジーズ |
高発現遺伝子由来のcDNAクローンの含有率を低減させたcDNAライブラリーの作製方法
|
US8476013B2
(en)
|
2008-09-16 |
2013-07-02 |
Sequenom, Inc. |
Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
|
US8962247B2
(en)
|
2008-09-16 |
2015-02-24 |
Sequenom, Inc. |
Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
|
EP2356129B1
(en)
*
|
2008-09-24 |
2013-04-03 |
Isis Pharmaceuticals, Inc. |
Substituted alpha-l-bicyclic nucleosides
|
ES2727549T3
(es)
|
2008-10-03 |
2019-10-17 |
Curna Inc |
Tratamiento de las enfermedades relacionadas con la apolipoproteína a1 por inhibición del transcrito antisentido natural a la apolipoproteína a1
|
US8987435B2
(en)
|
2008-10-24 |
2015-03-24 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and methods
|
US9846126B2
(en)
|
2008-10-27 |
2017-12-19 |
Genalyte, Inc. |
Biosensors based on optical probing and sensing
|
KR101692880B1
(ko)
|
2008-11-24 |
2017-01-04 |
노오쓰웨스턴 유니버시티 |
다가 rna-나노입자 구조체
|
US8927511B2
(en)
|
2008-12-04 |
2015-01-06 |
Curna, Inc. |
Treatment of vascular endothelial growth factor (VEGF) related diseases by inhibition of natural antisense transcript to VEGF
|
KR101840618B1
(ko)
|
2008-12-04 |
2018-03-20 |
큐알엔에이, 인크. |
종양 억제 유전자에 대한 천연 안티센스 전사체의 억제에 의해 종양 억제 유전자 관련된 질환의 치료
|
MX2011005910A
(es)
|
2008-12-04 |
2011-06-17 |
Opko Curna Llc |
Tratamiento de enfermedades relacionadas con eritropoyetina (epo) mediante inhibicion del transcrito antisentido natural a eritropoyetina.
|
WO2010080452A2
(en)
|
2008-12-18 |
2010-07-15 |
Quark Pharmaceuticals, Inc. |
siRNA COMPOUNDS AND METHODS OF USE THEREOF
|
CN102257147A
(zh)
|
2008-12-22 |
2011-11-23 |
凯津公司 |
在植物原生质体中使用双链rna提高靶基因改变的效率
|
AU2009335053B2
(en)
|
2008-12-30 |
2013-08-01 |
Gen-Probe Incorporated |
Compositions, kits and related methods for the detection and/or monitoring of Listeria
|
US20100233270A1
(en)
|
2009-01-08 |
2010-09-16 |
Northwestern University |
Delivery of Oligonucleotide-Functionalized Nanoparticles
|
EP2381965B1
(en)
|
2009-01-14 |
2020-05-06 |
Drexel University |
Modulation of pre-mrna using splice modulating oligonucleotides as therapeutic agents in the treatment of disease
|
CN102301011B
(zh)
|
2009-02-02 |
2014-05-07 |
埃克西库恩公司 |
对小rna进行定量的方法
|
WO2010091308A2
(en)
|
2009-02-06 |
2010-08-12 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and methods
|
CN102387817B
(zh)
|
2009-02-12 |
2018-01-30 |
库尔纳公司 |
通过抑制针对脑衍生神经营养因子(bdnf)的天然反义转录物来治疗bdnf相关的疾病
|
AU2010217928B2
(en)
|
2009-02-26 |
2013-06-06 |
Gen-Probe Incorporated |
Assay for detection of human parvovirus nucleic acid
|
EP2408919B1
(en)
|
2009-03-16 |
2017-10-18 |
CuRNA, Inc. |
Treatment of nuclear factor (erythroid-derived 2)-like 2 (nrf2) related diseases by inhibition of natural antisense transcript to nrf2
|
CA2755404C
(en)
|
2009-03-17 |
2020-03-24 |
Joseph Collard |
Treatment of delta-like 1 homolog (dlk1) related diseases by inhibition of natural antisense transcript to dlk1
|
US8481698B2
(en)
*
|
2009-03-19 |
2013-07-09 |
The President And Fellows Of Harvard College |
Parallel proximity ligation event analysis
|
JP6145270B2
(ja)
|
2009-04-15 |
2017-06-07 |
ノースウェスタン ユニバーシティ |
オリゴヌクレオチド機能化ナノ粒子の送達
|
EP3524275A1
(en)
|
2009-04-22 |
2019-08-14 |
Massachusetts Institute Of Technology |
Innate immune supression enables repeated delivery of long rna molecules
|
WO2010124231A2
(en)
|
2009-04-24 |
2010-10-28 |
The Board Of Regents Of The University Of Texas System |
Modulation of gene expression using oligomers that target gene regions downstream of 3' untranslated regions
|
WO2010126913A1
(en)
|
2009-04-27 |
2010-11-04 |
Gen-Probe Incorporated |
Methods and kits for use in the selective amplification of target sequences
|
EP2427553A4
(en)
|
2009-05-06 |
2012-11-07 |
Opko Curna Llc |
TREATMENT OF LIPID TRANSPORT AND METABOLISM-RELATED DISEASES BY INHIBITING THE NATURAL ANTISENSE TRANSCRIPT AGAINST A LIPID TRANSPORT AND METABOLIC TREATMENT
|
CN102803492B
(zh)
|
2009-05-06 |
2016-06-29 |
库尔纳公司 |
通过抑制针对三重四脯氨酸(ttp)的天然反义转录物来治疗ttp相关疾病
|
KR101742334B1
(ko)
|
2009-05-08 |
2017-06-01 |
큐알엔에이, 인크. |
Dmd 패밀리에 대한 천연 안티센스 전사체의 억제에 의한 디스트로핀 패밀리 관련된 질환의 치료
|
DK2432881T3
(en)
|
2009-05-18 |
2018-02-26 |
Curna Inc |
TREATMENT OF REPROGRAMMING FACTOR-RELATED DISEASES BY INHIBITING NATURAL ANTISENSE TRANSCRIPTS TO A REPROGRAMMING FACTOR
|
EP3597657B1
(en)
|
2009-05-21 |
2021-09-01 |
Siemens Healthcare Diagnostics Inc. |
Universal tags with non-natural nucleobases
|
US8895527B2
(en)
|
2009-05-22 |
2014-11-25 |
Curna, Inc. |
Treatment of transcription factor E3 (TFE3) and insulin receptor substrate 2(IRS2) related diseases by inhibition of natural antisense transcript to TFE3
|
WO2010138806A2
(en)
|
2009-05-28 |
2010-12-02 |
Curna, Inc. |
Treatment of antiviral gene related diseases by inhibition of natural antisense transcript to an antiviral gene
|
EP2440214A4
(en)
|
2009-06-08 |
2013-07-31 |
Quark Pharmaceuticals Inc |
METHODS OF TREATING CHRONIC RENAL DISEASE
|
US8951981B2
(en)
|
2009-06-16 |
2015-02-10 |
Curna, Inc. |
Treatment of paraoxonase 1 (PON1) related diseases by inhibition of natural antisense transcript to PON1
|
KR101801404B1
(ko)
|
2009-06-16 |
2017-12-20 |
큐알엔에이, 인크. |
콜라겐 유전자에 대한 천연 안티센스 전사체의 억제에 의한 콜라겐 유전자 관련된 질환의 치료
|
KR101807323B1
(ko)
|
2009-06-24 |
2017-12-08 |
큐알엔에이, 인크. |
Tnfr2에 대한 천연 안티센스 전사체의 억제에 의한 종양 괴사 인자 수용체 2(tnfr2) 관련된 질환의 치료
|
CA2765815A1
(en)
|
2009-06-26 |
2010-12-29 |
Opko Curna, Llc |
Treatment of down syndrome gene related diseases by inhibition of natural antisense transcript to a down syndrome gene
|
JP2011024434A
(ja)
|
2009-07-22 |
2011-02-10 |
Galaxy Pharma Inc |
オリゴヌクレオチドのスクリーニング方法及びオリゴヌクレオチドライブラリー
|
US20120252869A1
(en)
|
2009-07-24 |
2012-10-04 |
Opko Curna, Llc |
Treatment of sirtuin (sirt) related diseases by inhibition of natural antisense transcript to a sirtuin (sirt)
|
WO2011012136A1
(en)
|
2009-07-28 |
2011-02-03 |
Exiqon A/S |
A method for classifying a human cell sample as cancerous
|
ES2585360T3
(es)
|
2009-08-05 |
2016-10-05 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con un gen de la insulina (INS) por inhibición de la transcripción antisentido natural en un gen de la insulina (INS)
|
EP2462153B1
(en)
|
2009-08-06 |
2015-07-29 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexose nucleic acid analogs
|
CN104313027B
(zh)
|
2009-08-11 |
2018-11-20 |
库尔纳公司 |
通过抑制脂连蛋白(adipoq)的天然反义转录物治疗脂连蛋白(adipoq)相关疾病
|
KR101805213B1
(ko)
|
2009-08-21 |
2017-12-06 |
큐알엔에이, 인크. |
Chip에 대한 천연 안티센스 전사체의 억제에 의한 “hsp70-상호작용 단백질(chip)의 c-말단” 관련된 질환의 치료
|
JP5964232B2
(ja)
|
2009-08-25 |
2016-08-03 |
カッパーアールエヌエー,インコーポレイテッド |
‘iqモチーフ含有gtpアーゼ活性化タンパク質’(iqgap)に対する天然アンチセンス転写産物の阻害によるiqgap関連疾患の治療
|
EP2473522B1
(en)
|
2009-09-02 |
2016-08-17 |
Genentech, Inc. |
Mutant smoothened and methods of using the same
|
US20110196141A1
(en)
*
|
2009-09-07 |
2011-08-11 |
Council Of Scientific & Industrial Research |
Locked and unlocked 2'-o phosphoramidite nucleosides, process of preparation thereof and oligomers comprising the nucleosides
|
CA2775111C
(en)
|
2009-09-25 |
2019-12-31 |
Opko Curna, Llc |
Treatment of filaggrin (flg) related diseases by modulation of flg expression and activity
|
US20150025122A1
(en)
|
2009-10-12 |
2015-01-22 |
Larry J. Smith |
Methods and Compositions for Modulating Gene Expression Using Oligonucleotide Based Drugs Administered in vivo or in vitro
|
US9890408B2
(en)
|
2009-10-15 |
2018-02-13 |
Ibis Biosciences, Inc. |
Multiple displacement amplification
|
BR112012009409A2
(pt)
|
2009-10-22 |
2017-02-21 |
Genentech Inc |
método de identificação de uma substância inibidora, molécula antagonista, ácido nucleico isolado, vetor, célula hospedeira, método para fabricar a molécula, composição, artigo de fabricação, método de inibição de uma atividade biológica, método de tratamento de uma condição patológica, método para detectar msp em uma amostra e método para detectar hepsina em uma amostra
|
US20110129832A1
(en)
|
2009-10-27 |
2011-06-02 |
Swift Biosciences, Inc. |
Polynucleotide Primers and Probes
|
US8541562B2
(en)
|
2009-10-29 |
2013-09-24 |
Osaka University |
Bridged artificial nucleoside and nucleotide
|
EP2494075B1
(en)
|
2009-10-30 |
2018-04-04 |
Northwestern University |
Templated nanoconjugates
|
US20110110860A1
(en)
|
2009-11-02 |
2011-05-12 |
The Board Of Regents Of The University Of Texas System |
Modulation of ldl receptor gene expression with double-stranded rnas targeting the ldl receptor gene promoter
|
WO2011056215A1
(en)
|
2009-11-03 |
2011-05-12 |
Landers James P |
Versatile, visible method for detecting polymeric analytes
|
JP2013511285A
(ja)
|
2009-11-23 |
2013-04-04 |
スイフト・バイオサイエンシズ・インコーポレイテツド |
一本鎖標的分子を伸長させるデバイス
|
CN103755809B
(zh)
|
2009-11-30 |
2016-06-01 |
霍夫曼-拉罗奇有限公司 |
治疗和诊断表达slc34a2(tat211=seqid2)的肿瘤的抗体
|
KR101718534B1
(ko)
|
2009-12-09 |
2017-03-22 |
닛토덴코 가부시키가이샤 |
Hsp47 발현의 조절
|
EP2862929B1
(en)
|
2009-12-09 |
2017-09-06 |
Quark Pharmaceuticals, Inc. |
Compositions and methods for treating diseases, disorders or injury of the CNS
|
CA2782366A1
(en)
|
2009-12-16 |
2011-07-14 |
Opko Curna, Llc |
Treatment of membrane bound transcription factor peptidase, site 1 (mbtps1) related diseases by inhibition of natural antisense transcript to mbtps1
|
US9404160B2
(en)
|
2009-12-22 |
2016-08-02 |
Becton, Dickinson And Company |
Methods for the detection of microorganisms
|
ES2577017T3
(es)
|
2009-12-22 |
2016-07-12 |
Sequenom, Inc. |
Procedimientos y kits para identificar la aneuploidia
|
CA2782373C
(en)
|
2009-12-23 |
2019-03-26 |
Opko Curna, Llc |
Treatment of hepatocyte growth factor (hgf) related diseases by inhibition of natural antisense transcript to hgf
|
EP2515947B1
(en)
|
2009-12-23 |
2021-10-06 |
CuRNA, Inc. |
Treatment of uncoupling protein 2 (ucp2) related diseases by inhibition of natural antisense transcript to ucp2
|
JP2011130725A
(ja)
*
|
2009-12-25 |
2011-07-07 |
Contig I:Kk |
Lnaオリゴヌクレオチドとそれを含有する化粧品
|
EP2519633B1
(en)
|
2009-12-29 |
2017-10-25 |
CuRNA, Inc. |
Treatment of nuclear respiratory factor 1 (nrf1) related diseases by inhibition of natural antisense transcript to nrf1
|
EP2519634B1
(en)
|
2009-12-29 |
2016-06-01 |
CuRNA, Inc. |
TREATMENT OF TUMOR PROTEIN 63 (p63) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO p63
|
DK2519632T3
(en)
|
2009-12-31 |
2018-07-23 |
Curna Inc |
TREATMENT OF INSULIN RECEPTOR SUBSTRATE 2- (IRS2) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPTION TO IRS2 AND TRANSCRIPTION FACTOR E3 (TFE3)
|
JP5886757B2
(ja)
|
2010-01-04 |
2016-03-16 |
カッパーアールエヌエー,インコーポレイテッド |
インターフェロン調節因子8(irf8)に対する天然アンチセンス転写物の阻害によるインターフェロン調節因子8(irf8)関連疾患の治療
|
US8912157B2
(en)
|
2010-01-06 |
2014-12-16 |
Curna, Inc. |
Treatment of pancreatic developmental gene related diseases by inhibition of natural antisense transcript to a pancreatic developmental gene
|
WO2011084193A1
(en)
|
2010-01-07 |
2011-07-14 |
Quark Pharmaceuticals, Inc. |
Oligonucleotide compounds comprising non-nucleotide overhangs
|
WO2011085271A2
(en)
|
2010-01-08 |
2011-07-14 |
Isis Pharmaceuticals, Inc. |
Modulation of angiopoietin-like 3 expression
|
US9200277B2
(en)
|
2010-01-11 |
2015-12-01 |
Curna, Inc. |
Treatment of sex hormone binding globulin (SHBG) related diseases by inhibition of natural antisense transcript to SHBG
|
US8779118B2
(en)
|
2010-01-11 |
2014-07-15 |
Isis Pharmaceuticals, Inc. |
Base modified bicyclic nucleosides and oligomeric compounds prepared therefrom
|
US20110172296A1
(en)
*
|
2010-01-12 |
2011-07-14 |
Bennett C Frank |
Modulation of transforming growth factor-beta 1 expression
|
DK2529015T3
(en)
|
2010-01-25 |
2018-02-26 |
Curna Inc |
TREATMENT OF RNASE H1-RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO RNASE H1
|
US9574191B2
(en)
|
2010-02-03 |
2017-02-21 |
The Board Of Regents Of The University Of Texas System |
Selective inhibition of polyglutamine protein expression
|
EP3321361B1
(en)
|
2010-02-08 |
2019-03-27 |
Ionis Pharmaceuticals, Inc. |
Selective reduction of allelic variants
|
US9006198B2
(en)
|
2010-02-08 |
2015-04-14 |
Isis Pharmaceuticals, Inc. |
Selective reduction of allelic variants
|
JP5976548B2
(ja)
|
2010-02-22 |
2016-08-23 |
カッパーアールエヌエー,インコーポレイテッド |
Pycr1に対する天然アンチセンス転写物の阻害によるピロリン−5−カルボン酸レダクターゼ1(pycr1)関連疾患の治療
|
TW201437228A
(zh)
|
2010-02-23 |
2014-10-01 |
Genentech Inc |
用於診斷及治療腫瘤之組合物及方法
|
WO2011105901A2
(en)
|
2010-02-23 |
2011-09-01 |
Academisch Ziekenhuis Bij De Universiteit Van Amsterdam |
Antagonists of complement component 9 (c9) and uses thereof
|
WO2011105900A2
(en)
|
2010-02-23 |
2011-09-01 |
Academisch Ziekenhuis Bij De Universiteit Van Amsterdam |
Antagonists of complement component 8-alpha (c8-alpha) and uses thereof
|
WO2011105902A2
(en)
|
2010-02-23 |
2011-09-01 |
Academisch Ziekenhuis Bij De Universiteit Van Amsterdam |
Antagonists of complement component 8-beta (c8-beta) and uses thereof
|
US20110213011A1
(en)
*
|
2010-02-26 |
2011-09-01 |
Dean Nicholas M |
Modulation of smad3 expression
|
EP3214174B1
(en)
|
2010-03-04 |
2019-10-16 |
InteRNA Technologies B.V. |
A mirna molecule defined by its source and its diagnostic and therapeutic uses in diseases or conditions associated with emt
|
WO2011112732A2
(en)
|
2010-03-12 |
2011-09-15 |
The Brigham And Women's Hospital, Inc. |
Methods of treating vascular inflammatory disorders
|
WO2011113054A2
(en)
|
2010-03-12 |
2011-09-15 |
Aurasense Llc |
Crosslinked polynucleotide structure
|
US9193752B2
(en)
|
2010-03-17 |
2015-11-24 |
Isis Pharmaceuticals, Inc. |
5′-substituted bicyclic nucleosides and oligomeric compounds prepared therefrom
|
WO2011120023A1
(en)
|
2010-03-26 |
2011-09-29 |
Marina Biotech, Inc. |
Nucleic acid compounds for inhibiting survivin gene expression uses thereof
|
WO2011120046A2
(en)
|
2010-03-26 |
2011-09-29 |
Swift Biosciences, Inc. |
Methods and compositions for isolating polynucleotides
|
CA2795145C
(en)
|
2010-04-02 |
2019-01-22 |
Curna, Inc. |
Treatment of colony-stimulating factor 3 (csf3) related diseases by inhibition of natural antisense transcript to csf3
|
KR101900962B1
(ko)
|
2010-04-09 |
2018-09-20 |
큐알엔에이, 인크. |
섬유아세포 성장 인자 21 (fgf21)에 대한 자연 안티센스 전사체의 저해에 의한 섬유아세포 성장 인자 21 (fgf21) 관련된 질환의 치료
|
WO2011133584A2
(en)
|
2010-04-19 |
2011-10-27 |
Marina Biotech, Inc. |
Nucleic acid compounds for inhibiting hras gene expression and uses thereof
|
US20110269194A1
(en)
|
2010-04-20 |
2011-11-03 |
Swift Biosciences, Inc. |
Materials and methods for nucleic acid fractionation by solid phase entrapment and enzyme-mediated detachment
|
EP2563922A1
(en)
|
2010-04-26 |
2013-03-06 |
Marina Biotech, Inc. |
Nucleic acid compounds with conformationally restricted monomers and uses thereof
|
US8278049B2
(en)
|
2010-04-26 |
2012-10-02 |
Ann & Robert H. Lurie Children's Hospital of Chicago |
Selective enrichment of CpG islands
|
WO2011139843A2
(en)
|
2010-04-28 |
2011-11-10 |
Marina Biotech, Inc. |
Multi-sirna compositions for reducing gene expression
|
WO2011139695A2
(en)
|
2010-04-28 |
2011-11-10 |
Isis Pharmaceuticals, Inc. |
Modified 5' diphosphate nucleosides and oligomeric compounds prepared therefrom
|
EP2625186B1
(en)
|
2010-04-28 |
2016-07-27 |
Ionis Pharmaceuticals, Inc. |
5' modified nucleosides and oligomeric compounds prepared therefrom
|
WO2011139702A2
(en)
|
2010-04-28 |
2011-11-10 |
Isis Pharmaceuticals, Inc. |
Modified nucleosides and oligomeric compounds prepared therefrom
|
BR112012027547B1
(pt)
|
2010-04-29 |
2022-06-14 |
Ionis Pharmaceuticals, Inc |
Oligonucleotídeo modificado de fita simples, composição, e seus usos para tratar amiloidose transtirretina, reduzir os seus sintomas e para reduzir a expressão de mrna ou de proteína de transtirretina
|
US20130156845A1
(en)
|
2010-04-29 |
2013-06-20 |
Alnylam Pharmaceuticals, Inc. |
Lipid formulated single stranded rna
|
ES2465948T3
(es)
|
2010-04-30 |
2014-06-09 |
Exiqon A/S |
Procedimiento de hibridación in situ y tampón
|
SG185027A1
(en)
|
2010-05-03 |
2012-11-29 |
Genentech Inc |
Compositions and methods for the diagnosis and treatment of tumor
|
KR101936011B1
(ko)
|
2010-05-03 |
2019-01-07 |
큐알엔에이, 인크. |
시르투인 (sirt)에 대한 자연 안티센스 전사체의 저해에 의한 시르투인 (sirt) 관련된 질환의 치료
|
TWI531370B
(zh)
|
2010-05-14 |
2016-05-01 |
可娜公司 |
藉由抑制par4天然反股轉錄本治療par4相關疾病
|
KR101902197B1
(ko)
|
2010-05-26 |
2018-10-01 |
큐알엔에이, 인크. |
메티오닌 설폭시드 환원효소 a (msra)에 대한 자연 안티센스 전사체의 저해에 의한 메티오닌 설폭시드 환원효소 a (msra) 관련된 질환의 치료
|
WO2011150005A2
(en)
|
2010-05-26 |
2011-12-01 |
Opko Curna Llc |
Treatment of atonal homolog 1 (atoh1) related diseases by inhibition of natural antisense transcript to atoh1
|
WO2011150226A1
(en)
|
2010-05-26 |
2011-12-01 |
Landers James P |
Method for detecting nucleic acids based on aggregate formation
|
JP6081910B2
(ja)
|
2010-06-02 |
2017-02-15 |
アルナイラム ファーマシューティカルズ, インコーポレイテッドAlnylam Pharmaceuticals, Inc. |
肝線維症治療用組成物および肝線維症の治療法
|
US8957200B2
(en)
|
2010-06-07 |
2015-02-17 |
Isis Pharmaceuticals, Inc. |
Bicyclic nucleosides and oligomeric compounds prepared therefrom
|
KR101947801B1
(ko)
|
2010-06-07 |
2019-02-13 |
파이어플라이 바이오웍스, 인코포레이티드 |
다기능 입자들 스캐닝
|
WO2011156202A1
(en)
|
2010-06-08 |
2011-12-15 |
Isis Pharmaceuticals, Inc. |
Substituted 2 '-amino and 2 '-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
|
WO2011159836A2
(en)
|
2010-06-15 |
2011-12-22 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating interaction between proteins and target nucleic acids
|
WO2011163499A2
(en)
|
2010-06-23 |
2011-12-29 |
Opko Curna, Llc |
Treatment of sodium channel, voltage-gated, alpha subunit (scna) related diseases by inhibition of natural antisense transcript to scna
|
US9822397B2
(en)
|
2010-06-30 |
2017-11-21 |
Gen-Probe Incorporated |
Method and apparatus for identifying analyte-containing samples using single-read determination of analyte and process control signals
|
NZ704322A
(en)
|
2010-07-06 |
2016-07-29 |
Interna Technologies Bv |
Mirna and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated braf pathway
|
US9676810B2
(en)
|
2010-07-08 |
2017-06-13 |
The Brigham And Women's Hospital, Inc. |
Neuroprotective molecules and methods of treating neurological disorders and inducing stress granules
|
JP5998131B2
(ja)
|
2010-07-14 |
2016-09-28 |
カッパーアールエヌエー,インコーポレイテッド |
Discslargehomolog(dlg)dlg1への天然アンチセンス転写物の阻害によるdlg関連疾患の治療
|
EP2913402B1
(en)
|
2010-07-16 |
2017-10-18 |
Tocagen Inc. |
Retrovirus detection
|
KR20180105730A
(ko)
|
2010-07-19 |
2018-09-28 |
아이오니스 파마수티컬즈, 인코포레이티드 |
근육긴장성 이영양증-단백질 키나제(dmpk) 발현의 조절 방법
|
EP2412724A1
(en)
|
2010-07-29 |
2012-02-01 |
Centre National de la Recherche Scientifique (C.N.R.S) |
Regulation of Glypican 4 activity to modulate the fate of stem cells and uses thereof
|
WO2012018697A1
(en)
|
2010-08-02 |
2012-02-09 |
Integrated Dna Technologies, Inc. |
Methods for predicting stability and melting temperatures of nucleic acid duplexes
|
EP2625197B1
(en)
|
2010-10-05 |
2016-06-29 |
Genentech, Inc. |
Mutant smoothened and methods of using the same
|
KR101886457B1
(ko)
|
2010-10-06 |
2018-08-07 |
큐알엔에이, 인크. |
시알리다아제 4 (neu4)에 대한 자연 안티센스 전사체의 저해에 의한 neu4 관련된 질환의 치료
|
WO2012048113A2
(en)
|
2010-10-07 |
2012-04-12 |
The General Hospital Corporation |
Biomarkers of cancer
|
US8648053B2
(en)
|
2010-10-20 |
2014-02-11 |
Rosalind Franklin University Of Medicine And Science |
Antisense oligonucleotides that target a cryptic splice site in Ush1c as a therapeutic for Usher syndrome
|
JP6049623B2
(ja)
|
2010-10-22 |
2016-12-21 |
カッパーアールエヌエー,インコーポレイテッド |
α‐L‐イズロニダーゼ(IDUA)への天然アンチセンス転写物の阻害によるIDUA関連疾患の治療
|
CA2817002C
(en)
|
2010-11-05 |
2019-01-15 |
Miragen Therapeutics |
Base modified oligonucleotides
|
CA3060724A1
(en)
|
2010-11-05 |
2012-05-10 |
Genalyte, Inc. |
Optical analyte detection systems and methods of use
|
WO2012064758A2
(en)
|
2010-11-08 |
2012-05-18 |
Isis Pharmaceuticals, Inc. |
Methods for modulating factor 12 expression
|
AU2011325956B2
(en)
|
2010-11-12 |
2016-07-14 |
The General Hospital Corporation |
Polycomb-associated non-coding RNAs
|
CA2817960C
(en)
|
2010-11-17 |
2020-06-09 |
Isis Pharmaceuticals, Inc. |
Modulation of alpha synuclein expression
|
US10000752B2
(en)
|
2010-11-18 |
2018-06-19 |
Curna, Inc. |
Antagonat compositions and methods of use
|
WO2012068519A2
(en)
|
2010-11-19 |
2012-05-24 |
Sirius Genomics Inc. |
Markers associated with response to activated protein c administration, and uses thereof
|
CA2818824A1
(en)
|
2010-11-23 |
2012-05-31 |
Joseph Collard |
Treatment of nanog related diseases by inhibition of natural antisense transcript to nanog
|
EP2857512B1
(en)
|
2010-12-02 |
2016-06-29 |
Keygene N.V. |
Targeted alteration of DNA
|
CA2819431C
(en)
|
2010-12-02 |
2021-09-28 |
Keygene N.V. |
Targeted alteration of dna with oligonucleotides.
|
EP2648763A4
(en)
|
2010-12-10 |
2014-05-14 |
Alnylam Pharmaceuticals Inc |
COMPOSITIONS AND METHODS FOR EXPRESSION INHIBITION OF GENES KLF-1 AND BCL11A
|
WO2012078967A2
(en)
|
2010-12-10 |
2012-06-14 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for increasing erythropoietin (epo) production
|
CN103380215A
(zh)
|
2010-12-15 |
2013-10-30 |
米拉根医疗公司 |
包含锁定核苷酸的微rna抑制剂
|
EP2474617A1
(en)
|
2011-01-11 |
2012-07-11 |
InteRNA Technologies BV |
Mir for treating neo-angiogenesis
|
MX2017015093A
(es)
|
2011-01-11 |
2023-03-10 |
Seegene Inc |
Detección de secuencias de ácido nucleico objetivo mediante ensayo de escisión y extensión del pto.
|
WO2012097261A2
(en)
|
2011-01-14 |
2012-07-19 |
The General Hospital Corporation |
Methods targeting mir-128 for regulating cholesterol/lipid metabolism
|
AU2012212110A1
(en)
|
2011-02-02 |
2013-08-01 |
Excaliard Pharmaceuticals, Inc. |
Method of treating keloids or hypertrophic scars using antisense compounds targeting connective tissue growth factor (CTGF)
|
CN103391777A
(zh)
|
2011-02-02 |
2013-11-13 |
普林斯顿大学理事会 |
作为病毒产生调节剂的去乙酰化酶调节剂
|
EP3467109A1
(en)
|
2011-02-08 |
2019-04-10 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleotides and uses thereof
|
WO2012109495A1
(en)
|
2011-02-09 |
2012-08-16 |
Metabolic Solutions Development Company, Llc |
Cellular targets of thiazolidinediones
|
EP2681315B1
(en)
|
2011-03-03 |
2017-05-03 |
Quark Pharmaceuticals, Inc. |
Oligonucleotide modulators of the toll-like receptor pathway
|
JP6000287B2
(ja)
|
2011-03-03 |
2016-09-28 |
クォーク ファーマシューティカルズ インコーポレーティッドQuark Pharmaceuticals,Inc. |
肺疾患および損傷を治療するための組成物および方法
|
US9796979B2
(en)
|
2011-03-03 |
2017-10-24 |
Quark Pharmaceuticals Inc. |
Oligonucleotide modulators of the toll-like receptor pathway
|
US11078525B2
(en)
|
2011-03-29 |
2021-08-03 |
Seegene, Inc. |
Detection of target nucleic acid sequence by PTO cleavage and extension-dependent cleavage
|
KR102104401B1
(ko)
|
2011-03-29 |
2020-04-27 |
알닐람 파마슈티칼스 인코포레이티드 |
Tmprss6 유전자의 발현을 억제하기 위한 조성물 및 방법
|
CA2831915C
(en)
|
2011-04-01 |
2021-01-12 |
Isis Pharmaceuticals, Inc. |
Modulation of signal transducer and activator of transcription 3 (stat3) expression
|
EP2508607A1
(en)
|
2011-04-07 |
2012-10-10 |
Helmholtz-Zentrum für Infektionsforschung GmbH |
Medicament for liver regeneration and for treatment of liver failure
|
JP5951752B2
(ja)
|
2011-04-13 |
2016-07-13 |
アイオーニス ファーマシューティカルズ, インコーポレーテッドIonis Pharmaceuticals,Inc. |
Ptp1b発現のアンチセンス調節
|
UA118951C2
(uk)
|
2011-04-21 |
2019-04-10 |
Айоніс Фармасьютікалз, Інк. |
Модулювання експресії вірусу гепатиту b (hbv)
|
WO2012149154A1
(en)
|
2011-04-26 |
2012-11-01 |
Swift Biosciences, Inc. |
Polynucleotide primers and probes
|
WO2012149495A1
(en)
|
2011-04-27 |
2012-11-01 |
Isis Pharmaceuticals, Inc. |
Modulation of apolipoprotein ciii (apociii) expression
|
US8460872B2
(en)
|
2011-04-29 |
2013-06-11 |
Sequenom, Inc. |
Quantification of a minority nucleic acid species
|
WO2012151268A1
(en)
|
2011-05-02 |
2012-11-08 |
University Of Virginia Patent Foundation |
Method and system for high throughput optical and label free detection of analytes
|
US9353371B2
(en)
|
2011-05-02 |
2016-05-31 |
Ionis Pharmaceuticals, Inc. |
Antisense compounds targeting genes associated with usher syndrome
|
WO2012151289A2
(en)
|
2011-05-02 |
2012-11-08 |
University Of Virginia Patent Foundation |
Method and system to detect aggregate formation on a substrate
|
MX342067B
(es)
|
2011-05-04 |
2016-09-09 |
Seegene Inc |
Detección de secuencias de ácido nucleico objetivo por desdoblamiento e hibridización de oligonucleótido de sonda.
|
TWI658830B
(zh)
|
2011-06-08 |
2019-05-11 |
日東電工股份有限公司 |
Hsp47表現調控強化用類視色素脂質體
|
US10196637B2
(en)
|
2011-06-08 |
2019-02-05 |
Nitto Denko Corporation |
Retinoid-lipid drug carrier
|
WO2012170347A1
(en)
|
2011-06-09 |
2012-12-13 |
Isis Pharmaceuticals, Inc. |
Bicyclic nucleosides and oligomeric compounds prepared therefrom
|
RU2620980C2
(ru)
|
2011-06-09 |
2017-05-30 |
Курна, Инк. |
Лечение заболеваний, связанных с фратаксином (fxn), путем ингибирования природного антисмыслового транскрипта fxn
|
WO2012170947A2
(en)
|
2011-06-10 |
2012-12-13 |
Isis Pharmaceuticals, Inc. |
Methods for modulating factor 12 expression
|
CA2838984A1
(en)
|
2011-06-10 |
2012-12-13 |
Isis Pharmaceuticals, Inc. |
Methods for modulating kallikrein (klkb1) expression
|
EP2721156B1
(en)
|
2011-06-16 |
2016-12-21 |
Ionis Pharmaceuticals, Inc. |
Antisense modulation of fibroblast growth factor receptor 4 expression
|
AU2012272970A1
(en)
|
2011-06-21 |
2014-02-06 |
Alnylam Pharmaceuticals, Inc. |
Angiopoietin-like 3 (ANGPTL3) iRNA compositions and methods of use thereof
|
WO2012178033A2
(en)
|
2011-06-23 |
2012-12-27 |
Alnylam Pharmaceuticals, Inc. |
Serpina1 sirnas: compositions of matter and methods of treatment
|
AU2012275841A1
(en)
|
2011-06-27 |
2014-01-16 |
The Jackson Laboratory |
Methods and compositions for treatment of cancer and autoimmune disease
|
WO2013003808A1
(en)
|
2011-06-29 |
2013-01-03 |
Isis Pharmaceuticals, Inc. |
Methods for modulating kallikrein (klkb1) expression
|
JP2014526887A
(ja)
|
2011-08-01 |
2014-10-09 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
造血幹細胞移植の成功率を改善する方法
|
DK2742136T3
(da)
|
2011-08-11 |
2017-11-20 |
Ionis Pharmaceuticals Inc |
Gapmerforbindelser omfattende 5'-modificerede deoxyribonukleosider i gap og anvendelser deraf
|
DK2751270T3
(en)
|
2011-08-29 |
2018-10-29 |
Ionis Pharmaceuticals Inc |
OLIGOMER-CONJUGATE COMPLEXES AND THEIR USE
|
EP2751269B1
(en)
|
2011-08-29 |
2016-03-23 |
Ionis Pharmaceuticals, Inc. |
Methods and compounds useful in conditions related to repeat expansion
|
US9650421B2
(en)
|
2011-09-02 |
2017-05-16 |
Northwestern University |
Self-assembled nanostructures
|
EA029151B1
(ru)
|
2011-09-06 |
2018-02-28 |
Курна, Инк. |
ЛЕЧЕНИЕ ЗАБОЛЕВАНИЙ, СВЯЗАННЫХ С АЛЬФА-СУБЪЕДИНИЦАМИ ПОТЕНЦИАЛЗАВИСИМЫХ НАТРИЕВЫХ КАНАЛОВ (SCNxA), С ПОМОЩЬЮ МАЛЫХ МОЛЕКУЛ
|
JP2014526517A
(ja)
|
2011-09-14 |
2014-10-06 |
ノースウェスタン ユニバーシティ |
血液脳関門を通過することができるナノ抱合体
|
US9580708B2
(en)
|
2011-09-14 |
2017-02-28 |
Rana Therapeutics, Inc. |
Multimeric oligonucleotides compounds
|
BR112014006587B1
(pt)
|
2011-09-20 |
2021-07-27 |
Ionis Pharmaceuticals, Inc |
Composto compreendendo oligonucleotídeo que modula a expressão de gcgr, composição, bem como seu uso no tratamento ou prevenção de diabetes
|
US9175337B2
(en)
|
2011-09-21 |
2015-11-03 |
Gen-Probe Incorporated |
Methods for amplifying nucleic acid using tag-mediated displacement
|
WO2013055865A1
(en)
|
2011-10-11 |
2013-04-18 |
The Brigham And Women's Hospital, Inc. |
Micrornas in neurodegenerative disorders
|
US8901098B2
(en)
|
2011-10-25 |
2014-12-02 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of GCCR expression
|
US10202643B2
(en)
|
2011-10-31 |
2019-02-12 |
University Of Utah Research Foundation |
Genetic alterations in glioma
|
AU2012332517B9
(en)
|
2011-11-03 |
2017-08-10 |
Quark Pharmaceuticals, Inc. |
Methods and compositions for neuroprotection
|
ES2761343T3
(es)
|
2011-11-07 |
2020-05-19 |
Ionis Pharmaceuticals Inc |
Modulación de la expresión de TMPRSS6
|
US9243291B1
(en)
|
2011-12-01 |
2016-01-26 |
Isis Pharmaceuticals, Inc. |
Methods of predicting toxicity
|
JP2015502365A
(ja)
|
2011-12-12 |
2015-01-22 |
オンコイミューニン,インコーポレイティド |
オリゴヌクレオチドのイン−ビボ送達
|
JP6112569B2
(ja)
|
2011-12-16 |
2017-04-12 |
国立大学法人 東京医科歯科大学 |
キメラ2重鎖核酸
|
WO2013090648A1
(en)
|
2011-12-16 |
2013-06-20 |
modeRNA Therapeutics |
Modified nucleoside, nucleotide, and nucleic acid compositions
|
EP3369818B1
(en)
|
2011-12-22 |
2021-06-09 |
InteRNA Technologies B.V. |
Mirna for treating head and neck cancer
|
US9546368B2
(en)
|
2011-12-22 |
2017-01-17 |
Ionis Pharmaceuticals, Inc. |
Methods for modulating metastasis-associated-in-lung-adenocarcinoma-transcript-1 (MALAT-1) expression
|
ES2842938T3
(es)
|
2012-01-11 |
2021-07-15 |
Ionis Pharmaceuticals Inc |
Composiciones y métodos para la modulación del empalme de IKBKAP
|
US20140378533A1
(en)
|
2012-02-08 |
2014-12-25 |
Isis Pharmaceuticals, Inc. |
Modulation of rna by repeat targeting
|
EP2820129A1
(en)
|
2012-03-02 |
2015-01-07 |
Sequenom, Inc. |
Methods and processes for non-invasive assessment of genetic variations
|
ES2669244T3
(es)
|
2012-03-05 |
2018-05-24 |
Seegene, Inc. |
Detección de variación de nucleótidos en una secuencia de ácido nucleico diana mediante escisión CTO y ensayo de extensión
|
EP2825885B1
(en)
|
2012-03-12 |
2021-05-12 |
The Board of Trustees of the University of Illinois |
Optical analyte detection systems with magnetic enhancement
|
CN108300765B
(zh)
|
2012-03-13 |
2022-01-11 |
斯威夫特生物科学公司 |
用于通过核酸聚合酶对衬底多核苷酸进行大小受控的同聚物加尾的方法和组合物
|
WO2013138374A2
(en)
|
2012-03-15 |
2013-09-19 |
Curna, Inc. |
Treatment of brain derived neurotrophic factor (bdnf) related diseases by inhibition of natural antisense transcript to bdnf
|
WO2013138662A1
(en)
|
2012-03-16 |
2013-09-19 |
4S3 Bioscience, Inc. |
Antisense conjugates for decreasing expression of dmpk
|
WO2013142514A1
(en)
|
2012-03-19 |
2013-09-26 |
Isis Pharmaceuticals, Inc. |
Methods and compositions for modulating alpha-1-antitrypsin expression
|
EP2828289B1
(en)
|
2012-03-19 |
2020-02-26 |
The Brigham and Women's Hospital, Inc. |
Growth differentiation factor (gdf) 11 for treatment of age-related cardiovascular condition
|
JP6492003B2
(ja)
|
2012-03-30 |
2019-03-27 |
ワシントン・ユニバーシティWashington University |
発作を減少させるためおよび神経変性症候群を改質するためにタウ発現を調節する方法
|
JP2015518705A
(ja)
|
2012-04-02 |
2015-07-06 |
モデルナ セラピューティクス インコーポレイテッドModerna Therapeutics,Inc. |
ヒト疾患に関連する生物製剤およびタンパク質の産生のための修飾ポリヌクレオチド
|
JP2015516143A
(ja)
|
2012-04-02 |
2015-06-08 |
モデルナ セラピューティクス インコーポレイテッドModerna Therapeutics,Inc. |
ヒト疾患に関連するタンパク質の産生のための修飾ポリヌクレオチド
|
WO2013154799A1
(en)
|
2012-04-09 |
2013-10-17 |
Isis Pharmaceuticals, Inc. |
Tricyclic nucleosides and oligomeric compounds prepared therefrom
|
US9221864B2
(en)
|
2012-04-09 |
2015-12-29 |
Isis Pharmaceuticals, Inc. |
Tricyclic nucleic acid analogs
|
US9133461B2
(en)
|
2012-04-10 |
2015-09-15 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the ALAS1 gene
|
EP3336189A1
(en)
|
2012-04-20 |
2018-06-20 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleotides and uses thereof
|
US9127274B2
(en)
|
2012-04-26 |
2015-09-08 |
Alnylam Pharmaceuticals, Inc. |
Serpinc1 iRNA compositions and methods of use thereof
|
US20160002624A1
(en)
|
2012-05-17 |
2016-01-07 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide compositions
|
US9574193B2
(en)
|
2012-05-17 |
2017-02-21 |
Ionis Pharmaceuticals, Inc. |
Methods and compositions for modulating apolipoprotein (a) expression
|
US9920361B2
(en)
|
2012-05-21 |
2018-03-20 |
Sequenom, Inc. |
Methods and compositions for analyzing nucleic acid
|
WO2013177248A2
(en)
|
2012-05-22 |
2013-11-28 |
Isis Pharmaceuticals, Inc. |
Modulation of enhancer rna mediated gene expression
|
NZ631071A
(en)
|
2012-05-24 |
2017-02-24 |
Ionis Pharmaceuticals Inc |
Methods and compositions for modulating apolipoprotein(a) expression
|
PL2800811T3
(pl)
|
2012-05-25 |
2017-11-30 |
Emmanuelle Charpentier |
Sposoby i kompozycje do kierowanej RNA modyfikacji docelowego DNA i do modulacji transkrypcji kierowanej RNA
|
WO2013181665A1
(en)
|
2012-06-01 |
2013-12-05 |
Isis Pharmaceuticals, Inc. |
Antisense compounds targeting genes associated with fibronectin
|
US9487780B2
(en)
|
2012-06-01 |
2016-11-08 |
Ionis Pharmaceuticals, Inc. |
Antisense compounds targeting genes associated with fibronectin
|
WO2013184209A1
(en)
|
2012-06-04 |
2013-12-12 |
Ludwig Institute For Cancer Research Ltd. |
Mif for use in methods of treating subjects with a neurodegenerative disorder
|
EP2864482A4
(en)
|
2012-06-21 |
2016-02-10 |
Miragen Therapeutics Inc |
OLIGONUCLEOTIDE INHIBITORS COMPRISING A BLOCKED NUCLEIC ACID PATTERN
|
HUE051698T2
(hu)
|
2012-06-25 |
2021-03-29 |
Ionis Pharmaceuticals Inc |
UBE3A-ATS expresszió modulálása
|
AU2013290102B2
(en)
|
2012-07-13 |
2018-11-15 |
Sequenom, Inc. |
Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
|
EP2875131B1
(en)
|
2012-07-18 |
2018-03-14 |
Siemens Healthcare Diagnostics Inc. |
A method of normalizing biological samples
|
EP2877579B1
(en)
|
2012-07-27 |
2019-12-18 |
Ionis Pharmaceuticals, Inc. |
Modulation of renin-angiotensin system (ras) related diseases by angiotensinogen
|
AU2013202793B2
(en)
|
2012-07-31 |
2014-09-18 |
Gen-Probe Incorporated |
System, method and apparatus for automated incubation
|
EP2885312A4
(en)
|
2012-08-15 |
2016-01-20 |
Isis Pharmaceuticals Inc |
PROCESS FOR THE PREPARATION OF OLIGOMERIC COMPOUNDS USING MODIFIED STREAMING PROTOCOLS
|
HUE039676T2
(hu)
|
2012-09-06 |
2019-01-28 |
Univ Chicago |
Antiszensz polinukleotidok exon-ugrás indukálására és eljárások disztrófiák kezelésére
|
EP2897633B1
(en)
|
2012-09-18 |
2020-01-01 |
UTI Limited Partnership |
Treatment of pain by inhibition of usp5 de-ubiquitinase
|
WO2014046212A1
(ja)
|
2012-09-21 |
2014-03-27 |
国立大学法人大阪大学 |
グアニジン架橋を有する人工ヌクレオシドおよびオリゴヌクレオチド
|
WO2014051076A1
(ja)
|
2012-09-28 |
2014-04-03 |
株式会社Bna |
Bnaクランプ法
|
US9695418B2
(en)
|
2012-10-11 |
2017-07-04 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleosides and uses thereof
|
WO2014059364A1
(en)
|
2012-10-11 |
2014-04-17 |
Isis Pharmaceuticals, Inc. |
Methods of treating kennedy's disease
|
US9175291B2
(en)
|
2012-10-11 |
2015-11-03 |
Isis Pharmaceuticals Inc. |
Modulation of androgen receptor expression
|
EP3459549B1
(en)
|
2012-10-12 |
2022-04-06 |
Ionis Pharmaceuticals, Inc. |
Selective antisense compounds and uses thereof
|
US20160138014A1
(en)
|
2012-10-12 |
2016-05-19 |
Isis Pharmaceuticals, Inc. |
Antisense compounds and uses thereof
|
PT2906696T
(pt)
|
2012-10-15 |
2019-12-16 |
Univ California |
Métodos para modular a expressão de c9orf72
|
US10443052B2
(en)
|
2012-10-15 |
2019-10-15 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating C9ORF72 expression
|
US10577604B2
(en)
|
2012-10-15 |
2020-03-03 |
Ionis Pharmaceuticals, Inc. |
Methods for monitoring C9ORF72 expression
|
US9029335B2
(en)
|
2012-10-16 |
2015-05-12 |
Isis Pharmaceuticals, Inc. |
Substituted 2′-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
|
WO2014066239A1
(en)
|
2012-10-22 |
2014-05-01 |
Idenix Pharmaceuticals, Inc. |
2',4'-bridged nucleosides for hcv infection
|
SI2920308T1
(sl)
|
2012-10-31 |
2019-05-31 |
Ionis Pharmaceuticals, Inc. |
Zdravljenje raka
|
US20150299803A1
(en)
|
2012-11-05 |
2015-10-22 |
Pronai Therapeutics, Inc. |
Methods of Using Biomarkers for the Treatment of Cancer by Modulation of BCL2 Expression
|
EP2914621B1
(en)
|
2012-11-05 |
2023-06-07 |
Foundation Medicine, Inc. |
Novel ntrk1 fusion molecules and uses thereof
|
EP2917348A1
(en)
|
2012-11-06 |
2015-09-16 |
InteRNA Technologies B.V. |
Combination for use in treating diseases or conditions associated with melanoma, or treating diseases or conditions associated with activated b-raf pathway
|
EP2920304B1
(en)
|
2012-11-15 |
2019-03-06 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotide conjugates
|
LT2922554T
(lt)
|
2012-11-26 |
2022-06-27 |
Modernatx, Inc. |
Terminaliai modifikuota rnr
|
WO2014080004A1
(en)
|
2012-11-26 |
2014-05-30 |
Santaris Pharma A/S |
Compositions and methods for modulation of fgfr3 expression
|
WO2014093537A1
(en)
|
2012-12-11 |
2014-06-19 |
Isis Pharmaceuticals, Inc. |
Competitive modulation of micrornas
|
US9856474B2
(en)
|
2013-01-16 |
2018-01-02 |
Iowa State University Research Foundation, Inc. |
Deep intronic target for splicing correction on spinal muscular atrophy gene
|
EP2946014A2
(en)
|
2013-01-17 |
2015-11-25 |
Moderna Therapeutics, Inc. |
Signal-sensor polynucleotides for the alteration of cellular phenotypes
|
EP3939614A1
(en)
|
2013-01-18 |
2022-01-19 |
Foundation Medicine, Inc. |
Methods of treating cholangiocarcinoma
|
WO2014118272A1
(en)
|
2013-01-30 |
2014-08-07 |
Santaris Pharma A/S |
Antimir-122 oligonucleotide carbohydrate conjugates
|
DK2951305T3
(en)
|
2013-01-30 |
2018-10-29 |
Hoffmann La Roche |
LNA oligonucleotide KULHYDRATKONJUGATER
|
KR102190852B1
(ko)
|
2013-01-31 |
2020-12-14 |
아이오니스 파마수티컬즈, 인코포레이티드 |
변형된 커플링 프로토콜을 이용하는 올리고머 화합물의 제조 방법
|
EP3778618A1
(en)
|
2013-02-04 |
2021-02-17 |
Ionis Pharmaceuticals, Inc. |
Selective antisense compounds and uses thereof
|
AU2014216137B2
(en)
|
2013-02-14 |
2018-05-10 |
Ionis Pharmaceuticals, Inc. |
Modulation of Apolipoprotein C-III (ApoCIII) expression in lipoprotein lipase deficient (LPLD) populations
|
EP2957567B1
(en)
|
2013-02-18 |
2019-06-05 |
Shionogi & Co., Ltd. |
Nucleoside and nucleotide, having nitrogen-containing hetercycle structure
|
ES2662825T3
(es)
|
2013-02-25 |
2018-04-09 |
Seegene, Inc. |
Detección de variación de nucleótido en una secuencia de ácidos nucleicos diana
|
US20150366890A1
(en)
|
2013-02-25 |
2015-12-24 |
Trustees Of Boston University |
Compositions and methods for treating fungal infections
|
EP2961386B1
(en)
|
2013-02-28 |
2019-07-10 |
The General Hospital Corporation |
Mirna profiling compositions and methods of use
|
CN105143470B
(zh)
|
2013-02-28 |
2020-06-09 |
德克萨斯大学系统董事会 |
用于将癌症分类为易感于tmepai定向疗法以及治疗所述癌症的方法
|
AU2014222150A1
(en)
|
2013-03-01 |
2015-09-10 |
National University Corporation Tokyo Medical And Dental University |
Chimeric single-stranded antisense polynucleotides and double-stranded antisense agent
|
US20160024181A1
(en)
|
2013-03-13 |
2016-01-28 |
Moderna Therapeutics, Inc. |
Long-lived polynucleotide molecules
|
EP2971100A1
(en)
|
2013-03-13 |
2016-01-20 |
Sequenom, Inc. |
Primers for dna methylation analysis
|
WO2014142575A1
(en)
|
2013-03-13 |
2014-09-18 |
Seegene, Inc. |
Quantification of target nucleic acid using melting peak analysis
|
AU2014236156C1
(en)
|
2013-03-14 |
2020-12-17 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulating Tau expression
|
WO2014152211A1
(en)
|
2013-03-14 |
2014-09-25 |
Moderna Therapeutics, Inc. |
Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions
|
CN114015692A
(zh)
|
2013-03-14 |
2022-02-08 |
阿尔尼拉姆医药品有限公司 |
补体组分C5 iRNA组合物及其使用方法
|
CA2903487A1
(en)
|
2013-03-14 |
2014-09-25 |
Shire Human Genetic Therapies, Inc. |
Quantitative assessment for cap efficiency of messenger rna
|
EA201591286A1
(ru)
|
2013-03-14 |
2016-02-29 |
Шир Хьюман Дженетик Терапис, Инк. |
Количественная оценка эффективности кэп матричной рнк
|
US9273349B2
(en)
|
2013-03-14 |
2016-03-01 |
Affymetrix, Inc. |
Detection of nucleic acids
|
US9983206B2
(en)
|
2013-03-15 |
2018-05-29 |
The Board Of Trustees Of The University Of Illinois |
Methods and compositions for enhancing immunoassays
|
CA2902623A1
(en)
|
2013-03-15 |
2014-09-25 |
MiRagen Therapeutics, Inc. |
Locked nucleic acid inhibitor of mir-145 and uses thereof
|
JP6446026B2
(ja)
|
2013-03-15 |
2018-12-26 |
ミラゲン セラピューティクス, インコーポレイテッド |
架橋二環式ヌクレオシド
|
US9347095B2
(en)
|
2013-03-15 |
2016-05-24 |
Bio-Rad Laboratories, Inc. |
Digital assays for mutation detection
|
US8980864B2
(en)
|
2013-03-15 |
2015-03-17 |
Moderna Therapeutics, Inc. |
Compositions and methods of altering cholesterol levels
|
EP2983694B1
(en)
|
2013-04-08 |
2022-06-22 |
President and Fellows of Harvard College |
Compositions for rejuvenating skeletal muscle stem cells
|
US10590412B2
(en)
|
2013-04-19 |
2020-03-17 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulation nucleic acids through nonsense mediated decay
|
EP2992112B1
(en)
|
2013-04-22 |
2020-06-03 |
Icahn School of Medicine at Mount Sinai |
Mutations in pdgfrb and notch3 as causes of autosomal dominant infantile myofibromatosis
|
PE20160167A1
(es)
|
2013-04-29 |
2016-04-21 |
Sloan Kettering Inst Cancer |
Composiciones y metodos para alterar la senalizacion del segundo mensajero
|
NZ631512A
(en)
|
2013-05-01 |
2016-10-28 |
Ionis Pharmaceuticals Inc |
Compositions and methods for modulating apolipoprotein (a) expression
|
HUE038146T2
(hu)
|
2013-05-22 |
2018-09-28 |
Alnylam Pharmaceuticals Inc |
Serpina1 IRNS készítmények és eljárások alkalmazásukra
|
EP2999786A1
(en)
|
2013-05-22 |
2016-03-30 |
Alnylam Pharmaceuticals, Inc. |
Tmprss6 irna compositions and methods of use thereof
|
WO2014192310A1
(en)
|
2013-05-30 |
2014-12-04 |
National University Corporation Tokyo Medical And Dental University |
Double-stranded agents for delivering therapeutic oligonucleotides
|
US20160113911A1
(en)
|
2013-06-06 |
2016-04-28 |
The General Hospital Corporation |
Methods and compositions for the treatment of cancer
|
WO2014201143A1
(en)
|
2013-06-11 |
2014-12-18 |
President And Fellows Of Harvard College |
Methods and compositions for increasing neurogenesis and angiogenesis
|
ES2862125T3
(es)
|
2013-06-13 |
2021-10-07 |
Antisense Therapeutics Ltd |
Terapia combinada para acromegalia
|
CN105324119A
(zh)
|
2013-06-16 |
2016-02-10 |
国立大学法人东京医科齿科大学 |
具有外显子跳跃效应的双链反义核酸
|
US9909124B2
(en)
|
2013-06-21 |
2018-03-06 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating apolipoprotein C-III expression for improving a diabetic profile
|
US20160122761A1
(en)
|
2013-06-21 |
2016-05-05 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for modulation of target nucleic acids
|
MY183049A
(en)
|
2013-06-27 |
2021-02-09 |
Roche Innovation Ct Copenhagen As |
Antisense oligomers and conjugates targeting pcsk9
|
CN105452461B
(zh)
|
2013-07-02 |
2021-04-13 |
Ionis制药公司 |
生长激素受体的调节剂
|
RS62529B1
(sr)
|
2013-07-11 |
2021-11-30 |
Modernatx Inc |
Kompozicije koje sadrže sintetičke polinukleotide koji kodiraju proteine povezane sa crispr i sintetičke sgrnk i postupci upotrebe
|
JP6617702B2
(ja)
|
2013-07-15 |
2019-12-11 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
Fty720のアザサイクリック拘束アナログ
|
WO2015008985A1
(en)
|
2013-07-15 |
2015-01-22 |
Seegene, Inc. |
Detection of target nucleic acid sequence by pto cleavage and extension-dependent immobilized oligonucleotide hybridization
|
TWI657819B
(zh)
|
2013-07-19 |
2019-05-01 |
美商Ionis製藥公司 |
用於調節τ蛋白表現之組合物
|
US10435430B2
(en)
|
2013-07-31 |
2019-10-08 |
Ionis Pharmaceuticals, Inc. |
Methods and compounds useful in conditions related to repeat expansion
|
EA202191796A2
(ru)
|
2013-08-08 |
2022-03-31 |
Дзе Скриппс Рисёч Инститьют |
Способ сайт-специфического ферментативного мечения нуклеиновых кислот in vitro введением не встречающихся в природе нуклеотидов
|
TW201536329A
(zh)
|
2013-08-09 |
2015-10-01 |
Isis Pharmaceuticals Inc |
用於調節失養性肌強直蛋白質激酶(dmpk)表現之化合物及方法
|
CN105745335A
(zh)
|
2013-08-14 |
2016-07-06 |
佳根曼斯菲尔德有限公司 |
用于对cMET核酸进行多模态分析的组合物及方法
|
EP3033432A1
(en)
|
2013-08-14 |
2016-06-22 |
Qiagen Mansfield, Inc. |
Compositions and methods for multiplex analysis of nras and braf nucleic acids
|
WO2015031679A2
(en)
|
2013-08-28 |
2015-03-05 |
Isis Pharmaceuticals, Inc. |
Modulation of prekallikrein (pkk) expression
|
EP3041938A1
(en)
|
2013-09-03 |
2016-07-13 |
Moderna Therapeutics, Inc. |
Circular polynucleotides
|
WO2015034928A1
(en)
|
2013-09-03 |
2015-03-12 |
Moderna Therapeutics, Inc. |
Chimeric polynucleotides
|
DK3043827T3
(da)
|
2013-09-13 |
2019-08-26 |
Ionis Pharmaceuticals Inc |
Modulatorer af komplement faktor b
|
US9943604B2
(en)
|
2013-09-20 |
2018-04-17 |
Ionis Pharmaceuticals, Inc. |
Targeted therapeutic nucleosides and their use
|
CN105793423A
(zh)
|
2013-10-02 |
2016-07-20 |
阿尔尼拉姆医药品有限公司 |
用于抑制lect2基因表达的组合物和方法
|
AU2014329452B2
(en)
|
2013-10-03 |
2019-06-20 |
Moderna Therapeutics, Inc. |
Polynucleotides encoding low density lipoprotein receptor
|
NZ757749A
(en)
|
2013-10-04 |
2022-07-01 |
Icahn School Med Mount Sinai |
Compositions and methods for inhibiting expression of the alas1 gene
|
CN112080502A
(zh)
|
2013-10-11 |
2020-12-15 |
Ionis制药公司 |
用于调节c9orf72表达的组合物
|
US11162096B2
(en)
|
2013-10-14 |
2021-11-02 |
Ionis Pharmaceuticals, Inc |
Methods for modulating expression of C9ORF72 antisense transcript
|
EP3057693A4
(en)
|
2013-10-16 |
2017-08-09 |
The University Of British Columbia |
Device for formulating particles at small volumes
|
WO2015057008A2
(en)
|
2013-10-18 |
2015-04-23 |
Seegene, Inc. |
Detection of target nucleic acid sequence on solid phase by pto cleavage and extension using hcto assay
|
CA2928779A1
(en)
|
2013-10-21 |
2015-04-30 |
The General Hospital Corporation |
Methods relating to circulating tumor cell clusters and the treatment of cancer
|
WO2015061246A1
(en)
|
2013-10-21 |
2015-04-30 |
Isis Pharmaceuticals, Inc. |
Method for solution phase detritylation of oligomeric compounds
|
US10301622B2
(en)
|
2013-11-04 |
2019-05-28 |
Northwestern University |
Quantification and spatio-temporal tracking of a target using a spherical nucleic acid (SNA)
|
US20160298096A1
(en)
|
2013-11-18 |
2016-10-13 |
Crispr Therapeutics Ag |
Crispr-cas system materials and methods
|
WO2015075166A1
(en)
|
2013-11-22 |
2015-05-28 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and pharmaceutical compositions for treatment of a bacterial infection
|
ES2797679T3
(es)
|
2013-12-02 |
2020-12-03 |
Ionis Pharmaceuticals Inc |
Compuestos antisentido y usos de los mismos
|
CN105939699B
(zh)
|
2013-12-03 |
2020-10-02 |
西北大学 |
脂质体颗粒、制备所述脂质体颗粒的方法以及其用途
|
US10385388B2
(en)
|
2013-12-06 |
2019-08-20 |
Swift Biosciences, Inc. |
Cleavable competitor polynucleotides
|
CA2844640A1
(en)
|
2013-12-06 |
2015-06-06 |
The University Of British Columbia |
Method for treatment of castration-resistant prostate cancer
|
CA3107872A1
(en)
|
2013-12-12 |
2015-06-18 |
Alnylam Pharmaceuticals, Inc. |
Complement component irna compositions and methods of use thereof
|
EP3080266B1
(en)
|
2013-12-12 |
2021-02-03 |
The Regents of The University of California |
Methods and compositions for modifying a single stranded target nucleic acid
|
WO2015095527A1
(en)
|
2013-12-20 |
2015-06-25 |
The General Hosptial Corporation |
Methods and assays relating to circulating tumor cells
|
JP6643996B2
(ja)
|
2013-12-24 |
2020-02-12 |
アイオーニス ファーマシューティカルズ, インコーポレーテッドIonis Pharmaceuticals,Inc. |
アンジオポエチン様3発現の調節
|
WO2015118407A2
(en)
|
2014-01-29 |
2015-08-13 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Oligonucleotides and methods for inhibiting or reducing bacterial biofilms
|
AU2015214264B2
(en)
|
2014-02-04 |
2018-12-20 |
Curis, Inc. |
Mutant Smoothened and methods of using the same
|
EA201691587A1
(ru)
|
2014-02-11 |
2017-01-30 |
Элнилэм Фармасьютикалз, Инк. |
КОМПОЗИЦИИ НА ОСНОВЕ iRNA ДЛЯ КЕТОГЕКСОКИНАЗЫ (KHK) И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
|
CA2939822C
(en)
*
|
2014-02-18 |
2018-09-25 |
Osaka University |
Crosslinked nucleoside and nucleotide
|
WO2015138774A1
(en)
|
2014-03-13 |
2015-09-17 |
Sequenom, Inc. |
Methods and processes for non-invasive assessment of genetic variations
|
US10036019B2
(en)
|
2014-03-17 |
2018-07-31 |
Ionis Pharmaceuticals, Inc. |
Bicyclic carbocyclic nucleosides and oligomeric compounds prepared therefrom
|
CN116970607A
(zh)
|
2014-03-19 |
2023-10-31 |
Ionis制药公司 |
用于调节共济失调蛋白2表达的组合物
|
EP3757214B1
(en)
|
2014-04-01 |
2022-06-15 |
Biogen MA Inc. |
Compositions for modulating sod-1 expression
|
US10513706B2
(en)
|
2014-04-09 |
2019-12-24 |
The Scripps Research Institute |
Import of unnatural or modified nucleoside triphosphates into cells via nucleic acid triphosphate transporters
|
WO2015164693A1
(en)
|
2014-04-24 |
2015-10-29 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising alpha-beta-constrained nucleic acid
|
EP3137476B1
(en)
|
2014-04-28 |
2019-10-09 |
Ionis Pharmaceuticals, Inc. |
Linkage modified oligomeric compounds
|
EP3137115B1
(en)
|
2014-05-01 |
2020-10-14 |
Ionis Pharmaceuticals, Inc. |
Method for synthesis of reactive conjugate clusters
|
PT3137605T
(pt)
|
2014-05-01 |
2020-12-18 |
Ionis Pharmaceuticals Inc |
Composições e métodos para modulação da expressão de angiopoietina de tipo 3
|
KR20200102553A
(ko)
|
2014-05-01 |
2020-08-31 |
아이오니스 파마수티컬즈, 인코포레이티드 |
성장 호르몬 수용체 발현을 조절하기 위한 조성물 및 방법
|
EP3608406B1
(en)
|
2014-05-01 |
2023-02-15 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulating complement factor b expression
|
RU2703411C2
(ru)
|
2014-05-01 |
2019-10-16 |
Ионис Фармасьютикалз, Инк. |
Композиции и способы модулирования экспрессии пкп
|
WO2015175510A1
(en)
|
2014-05-12 |
2015-11-19 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for treating a serpinc1-associated disorder
|
WO2015179693A1
(en)
|
2014-05-22 |
2015-11-26 |
Isis Pharmaceuticals, Inc. |
Conjugated antisense compounds and their use
|
SG11201609376SA
(en)
|
2014-05-22 |
2016-12-29 |
Alnylam Pharmaceuticals Inc |
Angiotensinogen (agt) irna compositions and methods of use thereof
|
WO2015187541A1
(en)
|
2014-06-02 |
2015-12-10 |
Children's Medical Center Corporation |
Methods and compositions for immunomodulation
|
TR201908550T4
(tr)
|
2014-06-04 |
2019-07-22 |
Exicure Inc |
Profilaktik veya terapötik uygulamalar için lipozomal sferik nükleik asitler tarafından immün modülatörlerin çok değerlikli teslimi.
|
JP6851201B2
(ja)
|
2014-06-10 |
2021-03-31 |
エラスムス ユニバーシティ メディカルセンター ロッテルダムErasmus University Medical Center Rotterdam |
ポンペ病の治療に有用なアンチセンスオリゴヌクレオチド
|
GB201410693D0
(en)
|
2014-06-16 |
2014-07-30 |
Univ Southampton |
Splicing modulation
|
TW201620526A
(zh)
|
2014-06-17 |
2016-06-16 |
愛羅海德研究公司 |
用於抑制α-1抗胰蛋白酶基因表現之組合物及方法
|
US10301624B2
(en)
|
2014-06-25 |
2019-05-28 |
The General Hospital Corporation |
Targeting human satellite II (HSATII)
|
US20170211073A1
(en)
*
|
2014-07-10 |
2017-07-27 |
Kenji Nakano |
Antisense antineoplastic agent
|
CA2955250A1
(en)
|
2014-07-16 |
2016-01-21 |
Moderna Therapeutics, Inc. |
Chimeric polynucleotides
|
WO2016014846A1
(en)
|
2014-07-23 |
2016-01-28 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of intrabodies
|
JP6562517B2
(ja)
*
|
2014-07-31 |
2019-08-21 |
国立大学法人大阪大学 |
架橋型ヌクレオシドおよびヌクレオチド
|
MX2017002085A
(es)
|
2014-08-19 |
2017-08-21 |
Univ Northwestern |
Tratamientos con nanopartículas núcleo-corteza de proteína/oligonucleótido.
|
WO2016027168A2
(en)
|
2014-08-20 |
2016-02-25 |
Lifesplice Pharma Llc |
Splice modulating oligonucleotides and methods of use thereof
|
IL234246A0
(en)
|
2014-08-21 |
2014-11-30 |
Omrix Biopharmaceuticals Ltd |
Stabilized thrombin
|
WO2016033424A1
(en)
|
2014-08-29 |
2016-03-03 |
Genzyme Corporation |
Methods for the prevention and treatment of major adverse cardiovascular events using compounds that modulate apolipoprotein b
|
US10385343B2
(en)
|
2014-08-29 |
2019-08-20 |
Children's Medical Center Corporation |
Methods and compositions for the treatment of cancer
|
WO2016034611A1
(en)
|
2014-09-02 |
2016-03-10 |
Max-Delbrück-Centrum für Molekulare Medizin |
Antisense oligonucleotides targeting 3'utr region of a20
|
EP3191591A1
(en)
|
2014-09-12 |
2017-07-19 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotide agents targeting complement component c5 and methods of use thereof
|
EA201790642A1
(ru)
|
2014-09-18 |
2017-09-29 |
Ти Юниверсити Оф Бритиш Коламбиа |
Аллель-специфическая терапия для гаплотипов болезни хантингтона
|
CN107002098A
(zh)
|
2014-09-29 |
2017-08-01 |
杰克逊实验室 |
通过电穿孔高效率、高通量产生遗传修饰哺乳动物
|
AU2015327836B2
(en)
|
2014-10-03 |
2021-07-01 |
Cold Spring Harbor Laboratory |
Targeted augmentation of nuclear gene output
|
JOP20200115A1
(ar)
|
2014-10-10 |
2017-06-16 |
Alnylam Pharmaceuticals Inc |
تركيبات وطرق لتثبيط التعبير الجيني عن hao1 (حمض أوكسيداز هيدروكسيلي 1 (أوكسيداز جليكولات))
|
WO2016061131A1
(en)
|
2014-10-14 |
2016-04-21 |
The J. David Gladstone Institutes |
Compositions and methods for reactivating latent immunodeficiency virus
|
EP3207138B1
(en)
|
2014-10-17 |
2020-07-15 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotide agents targeting aminolevulinic acid synthase-1 (alas1) and uses thereof
|
EP3212794B1
(en)
|
2014-10-30 |
2021-04-07 |
Genzyme Corporation |
Polynucleotide agents targeting serpinc1 (at3) and methods of use thereof
|
SG11201703646SA
(en)
|
2014-11-10 |
2017-06-29 |
Glaxosmithkline Intellectual Property (No 2) Ltd |
Combination long acting compositions and methods for hepatitis c
|
JOP20200092A1
(ar)
|
2014-11-10 |
2017-06-16 |
Alnylam Pharmaceuticals Inc |
تركيبات iRNA لفيروس الكبد B (HBV) وطرق لاستخدامها
|
US20170312297A1
(en)
|
2014-11-10 |
2017-11-02 |
Glaxosmithkline Intellectual Property (No. 2) Limited |
Long Acting Pharmaceutical Compositions For Hepatitis C
|
WO2016077704A1
(en)
|
2014-11-14 |
2016-05-19 |
The Regents Of The University Of California |
Modulation of agpat5 expression
|
WO2016081444A1
(en)
|
2014-11-17 |
2016-05-26 |
Alnylam Pharmaceuticals, Inc. |
Apolipoprotein c3 (apoc3) irna compositions and methods of use thereof
|
JP2017537619A
(ja)
|
2014-11-21 |
2017-12-21 |
ノースウェスタン ユニバーシティ |
球状核酸ナノ粒子複合体の配列特異的細胞内取込
|
US10400243B2
(en)
|
2014-11-25 |
2019-09-03 |
Ionis Pharmaceuticals, Inc. |
Modulation of UBE3A-ATS expression
|
EP3229842B1
(en)
|
2014-12-08 |
2022-07-06 |
The Board of Regents of The University of Texas System |
Lipocationic polymers and uses thereof
|
AU2015364508A1
(en)
|
2014-12-18 |
2017-07-06 |
Alnylam Pharmaceuticals, Inc. |
ReversirTM compounds
|
US9688707B2
(en)
|
2014-12-30 |
2017-06-27 |
Ionis Pharmaceuticals, Inc. |
Bicyclic morpholino compounds and oligomeric compounds prepared therefrom
|
US10793855B2
(en)
|
2015-01-06 |
2020-10-06 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of C9ORF72 antisense transcript
|
EP3247386A4
(en)
|
2015-01-20 |
2018-10-03 |
The Children's Medical Center Corporation |
Anti-net compounds for treating and preventing fibrosis and for facilitating wound healing
|
WO2016118612A2
(en)
|
2015-01-20 |
2016-07-28 |
MiRagen Therapeutics, Inc. |
Mir-92 inhibitors and uses thereof
|
JP2018512597A
(ja)
|
2015-02-04 |
2018-05-17 |
ジェネンテック, インコーポレイテッド |
突然変異体スムースンド及びその使用方法
|
US10676726B2
(en)
|
2015-02-09 |
2020-06-09 |
Duke University |
Compositions and methods for epigenome editing
|
CA2976445A1
(en)
|
2015-02-13 |
2016-08-18 |
Alnylam Pharmaceuticals, Inc. |
Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof
|
EP3261643B1
(en)
|
2015-02-26 |
2020-11-25 |
Ionis Pharmaceuticals, Inc. |
Allele specific modulators of p23h rhodopsin
|
EP3265564B1
(en)
|
2015-03-03 |
2022-01-26 |
Ionis Pharmaceuticals, Inc. |
Methods for modulating mecp2 expression
|
WO2016141236A1
(en)
|
2015-03-03 |
2016-09-09 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating mecp2 expression
|
EP3277817A4
(en)
|
2015-04-03 |
2018-12-05 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating tmprss6 expression
|
WO2016164463A1
(en)
|
2015-04-07 |
2016-10-13 |
The General Hospital Corporation |
Methods for reactivating genes on the inactive x chromosome
|
DK3283500T3
(en)
|
2015-04-08 |
2020-11-16 |
Univ Chicago |
Compositions and methods for correcting limb girdle muscular dystrophy type 2C using exon skipping
|
US10745702B2
(en)
|
2015-04-08 |
2020-08-18 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the LECT2 gene
|
WO2016167780A1
(en)
|
2015-04-16 |
2016-10-20 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of c9orf72 antisense transcript
|
KR102104163B1
(ko)
|
2015-04-16 |
2020-04-23 |
아이오니스 파마수티컬즈, 인코포레이티드 |
C9orf72 발현을 조절하기 위한 조성물
|
AU2016252998B2
(en)
|
2015-04-24 |
2021-11-04 |
Atila Biosystems Incorporated |
Amplification with primers of limited nucleotide composition
|
US10392607B2
(en)
|
2015-06-03 |
2019-08-27 |
The Regents Of The University Of California |
Cas9 variants and methods of use thereof
|
EP3307316A1
(en)
|
2015-06-12 |
2018-04-18 |
Alnylam Pharmaceuticals, Inc. |
Complement component c5 irna compositions and methods of use thereof
|
WO2016205323A1
(en)
|
2015-06-18 |
2016-12-22 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotde agents targeting hydroxyacid oxidase (glycolate oxidase, hao1) and methods of use thereof
|
WO2016209862A1
(en)
|
2015-06-23 |
2016-12-29 |
Alnylam Pharmaceuticals, Inc. |
Glucokinase (gck) irna compositions and methods of use thereof
|
EP3314250A4
(en)
|
2015-06-26 |
2018-12-05 |
Beth Israel Deaconess Medical Center, Inc. |
Cancer therapy targeting tetraspanin 33 (tspan33) in myeloid derived suppressor cells
|
CA2990699A1
(en)
|
2015-06-29 |
2017-01-05 |
Ionis Pharmaceuticals, Inc. |
Modified crispr rna and modified single crispr rna and uses thereof
|
US10494632B2
(en)
|
2015-07-10 |
2019-12-03 |
Alnylam Pharmaceuticals, Inc. |
Insulin-like growth factor binding protein, acid labile subunit (IGFALS) compositions and methods of use thereof
|
ES2917181T3
(es)
|
2015-07-10 |
2022-07-07 |
Ionis Pharmaceuticals Inc |
Moduladores de diacilglicerol aciltransferasa 2 (DGAT2)
|
JP2018520683A
(ja)
|
2015-07-17 |
2018-08-02 |
アルニラム ファーマスーティカルズ インコーポレイテッドAlnylam Pharmaceuticals, Inc. |
多標的単一体コンジュゲート
|
JP2018140938A
(ja)
*
|
2015-07-24 |
2018-09-13 |
日産化学株式会社 |
人工ヌクレオシド及び人工ヌクレオチド並びに人工オリゴヌクレオチド
|
EP3331536A4
(en)
|
2015-08-03 |
2019-03-27 |
The Regents of The University of California |
COMPOSITIONS AND METHODS FOR MODULATING ABHD2 ACTIVITY
|
WO2017032726A1
(en)
|
2015-08-24 |
2017-03-02 |
Roche Innovation Center Copenhagen A/S |
Lna-g process
|
EP3344769B1
(en)
|
2015-09-02 |
2024-04-17 |
Alnylam Pharmaceuticals, Inc. |
Programmed cell death 1 ligand 1 (pd-l1) irna compositions and methods of use thereof
|
PT3349802T
(pt)
|
2015-09-14 |
2021-10-15 |
Univ Texas |
Dendrímeros lipocatiónicos e suas utilizações
|
TW201718618A
(zh)
*
|
2015-09-18 |
2017-06-01 |
田邊三菱製藥股份有限公司 |
架橋型核酸GuNA,其製造方法,及中間體化合物
|
EP3353328A4
(en)
|
2015-09-24 |
2019-06-12 |
Ionis Pharmaceuticals, Inc. |
MODULATORS OF KRAS EXPRESSION
|
MX2018003685A
(es)
|
2015-09-24 |
2018-08-15 |
Univ California |
Moleculas tipo esfingolipidos sinteticas, farmacos, metodos de su sintesis y metodos de tratamiento.
|
AU2016339053A1
(en)
|
2015-09-24 |
2018-04-12 |
Crispr Therapeutics Ag |
Novel family of RNA-programmable endonucleases and their uses in genome editing and other applications
|
PT3353303T
(pt)
|
2015-09-25 |
2023-10-10 |
Academisch Ziekenhuis Leiden |
Composições e métodos para modulação da expressão de ataxina 3
|
BR122020023854B1
(pt)
|
2015-10-08 |
2022-11-29 |
Ionis Pharmaceuticals, Inc |
Composto compreendendo oligonucleotídeo modificado e seu uso, uso do oligonucleotídeo modificado, composição e seu uso
|
WO2017060731A1
(en)
|
2015-10-09 |
2017-04-13 |
University Of Southampton |
Modulation of gene expression and screening for deregulated protein expression
|
WO2017068087A1
(en)
|
2015-10-22 |
2017-04-27 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotide detection method
|
EP3368692B1
(en)
|
2015-10-29 |
2021-07-21 |
Temple University Of The Commonwealth System Of Higher Education |
Modification of 3' terminal ends of nucleic acids by dna polymerase theta
|
US11260073B2
(en)
|
2015-11-02 |
2022-03-01 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating C90RF72
|
EP3371211A4
(en)
|
2015-11-04 |
2019-08-21 |
Icahn School of Medicine at Mount Sinai |
METHOD FOR THE TREATMENT OF TUMORS AND CANCER AND IDENTIFICATION OF CANDIDATE PATIENTS FOR SUCH TREATMENT
|
BR122023026882A2
(pt)
|
2015-11-06 |
2024-01-23 |
Ionis Pharmaceuticals, Inc |
Uso de um composto oligomérico
|
WO2017079745A1
(en)
|
2015-11-06 |
2017-05-11 |
Ionis Pharmaceuticals, Inc. |
Conjugated antisense compounds for use in therapy
|
CN116064539A
(zh)
|
2015-11-12 |
2023-05-05 |
豪夫迈·罗氏有限公司 |
用于诱导父本ube3a表达的寡核苷酸
|
AU2016359629B2
(en)
|
2015-11-23 |
2023-03-09 |
Ranjan BATRA |
Tracking and manipulating cellular RNA via nuclear delivery of CRISPR/Cas9
|
WO2017096395A1
(en)
|
2015-12-04 |
2017-06-08 |
Ionis Pharmaceuticals, Inc. |
Methods of treating breast cancer
|
WO2017099579A1
(en)
|
2015-12-07 |
2017-06-15 |
Erasmus University Medical Center Rotterdam |
Enzymatic replacement therapy and antisense therapy for pompe disease
|
WO2017098468A1
(en)
|
2015-12-09 |
2017-06-15 |
Novartis Ag |
Label-free analysis of rna capping efficiency using rnase h, probes and liquid chromatography/mass spectrometry
|
US11096956B2
(en)
|
2015-12-14 |
2021-08-24 |
Stoke Therapeutics, Inc. |
Antisense oligomers and uses thereof
|
EP3933041B1
(en)
|
2015-12-14 |
2024-01-31 |
Cold Spring Harbor Laboratory |
Antisense oligomers for treatment of autosomal dominant retardation
|
WO2017106767A1
(en)
|
2015-12-18 |
2017-06-22 |
The Scripps Research Institute |
Production of unnatural nucleotides using a crispr/cas9 system
|
JOP20200228A1
(ar)
|
2015-12-21 |
2017-06-16 |
Novartis Ag |
تركيبات وطرق لخفض تعبير البروتين tau
|
CA3006599A1
(en)
|
2016-01-05 |
2017-07-13 |
Ionis Pharmaceuticals, Inc. |
Methods for reducing lrrk2 expression
|
EP3400097B1
(en)
|
2016-01-06 |
2021-01-27 |
The University Of British Columbia |
Bifurcating mixers and methods of their use and manufacture
|
CN109414001A
(zh)
|
2016-01-15 |
2019-03-01 |
杰克逊实验室 |
通过cas9蛋白的多循环电穿孔产生的遗传修饰的非人哺乳动物
|
AU2017211461B2
(en)
|
2016-01-26 |
2023-01-12 |
Nissan Chemical Corporation |
Single-stranded oligonucleotide
|
EP3411396A1
(en)
|
2016-02-04 |
2018-12-12 |
Curis, Inc. |
Mutant smoothened and methods of using the same
|
JP6853537B2
(ja)
|
2016-02-17 |
2021-03-31 |
国立大学法人東京工業大学 |
人工ヌクレオシド及び人工ヌクレオチド並びに人工オリゴヌクレオチド
|
CA3054284A1
(en)
|
2016-02-25 |
2017-08-31 |
The Brigham And Women's Hospital, Inc. |
Treatment methods for fibrosis targeting smoc2
|
US11008608B2
(en)
|
2016-02-26 |
2021-05-18 |
The Board Of Trustees Of The Leland Stanford Junior University |
Multiplexed single molecule RNA visualization with a two-probe proximity ligation system
|
AU2017229778A1
(en)
|
2016-03-09 |
2018-08-16 |
Ionis Pharmaceuticals, Inc. |
Methods and compositions for inhibiting PMP22 expression
|
ES2857702T3
(es)
|
2016-03-14 |
2021-09-29 |
Hoffmann La Roche |
Oligonucleótidos para la reducción de la expresión de PD-L1
|
AU2017234678A1
(en)
|
2016-03-16 |
2018-08-16 |
Ionis Pharmaceuticals, Inc. |
Methods of modulating KEAP1
|
WO2017161168A1
(en)
|
2016-03-16 |
2017-09-21 |
Ionis Pharmaceuticals, Inc. |
Modulation of dyrk1b expression
|
AU2017248637A1
(en)
|
2016-04-13 |
2018-09-27 |
Ionis Pharmaceuticals, Inc. |
Methods for reducing C9ORF72 expression
|
JP6985288B2
(ja)
|
2016-04-14 |
2021-12-22 |
エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft |
トリチル−モノ−GalNAc化合物とその利用
|
MA45295A
(fr)
|
2016-04-19 |
2019-02-27 |
Alnylam Pharmaceuticals Inc |
Composition d'arni de protéine de liaison de lipoprotéines haute densité (hdlbp/vigiline) et procédés pour les utiliser
|
US11246868B2
(en)
|
2016-04-26 |
2022-02-15 |
Icahn School Of Medicine At Mount Sinai |
Treatment of hippo pathway mutant tumors and methods of identifying subjects as candidates for treatment
|
BR112018073699A2
(pt)
|
2016-05-16 |
2019-05-07 |
The Board Of Regents Of The University Of Texas System |
amino lipídios de sulfonamida catiônica e amino lipídios zwiteriônico anfifílicos
|
US20190256845A1
(en)
|
2016-06-10 |
2019-08-22 |
Alnylam Pharmaceuticals, Inc. |
COMPLEMENT COMPONENT C5 iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH)
|
CA3027953A1
(en)
|
2016-06-15 |
2017-12-21 |
Streck, Inc. |
Assays and methods for determining microbial resistance
|
US10337051B2
(en)
|
2016-06-16 |
2019-07-02 |
The Regents Of The University Of California |
Methods and compositions for detecting a target RNA
|
WO2017219017A1
(en)
|
2016-06-17 |
2017-12-21 |
Ionis Pharmaceuticals, Inc. |
Modulation of gys1 expression
|
MA45496A
(fr)
|
2016-06-17 |
2019-04-24 |
Hoffmann La Roche |
Molécules d'acide nucléique pour la réduction de l'arnm de padd5 ou pad7 pour le traitement d'une infection par l'hépatite b
|
HUE060123T2
(hu)
|
2016-06-24 |
2023-01-28 |
Scripps Research Inst |
Új nukleozid-trifoszfát-transzporter és alkalmazásai
|
BR112018077321A2
(pt)
|
2016-07-01 |
2019-04-24 |
F. Hoffmann-La Roche Ag |
oligonucleotídeos anti-sentido para modular a expressão de htra1
|
PL3484524T3
(pl)
|
2016-07-15 |
2023-03-20 |
Ionis Pharmaceuticals, Inc. |
Związki i sposoby modulacji smn2
|
NL2017294B1
(en)
|
2016-08-05 |
2018-02-14 |
Univ Erasmus Med Ct Rotterdam |
Natural cryptic exon removal by pairs of antisense oligonucleotides.
|
NL2017295B1
(en)
|
2016-08-05 |
2018-02-14 |
Univ Erasmus Med Ct Rotterdam |
Antisense oligomeric compound for Pompe disease
|
WO2018039629A2
(en)
|
2016-08-25 |
2018-03-01 |
Northwestern University |
Micellar spherical nucleic acids from thermoresponsive, traceless templates
|
SG10201607303YA
(en)
|
2016-09-01 |
2018-04-27 |
Agency Science Tech & Res |
Antisense oligonucleotides to induce exon skipping
|
US10793859B2
(en)
|
2016-09-14 |
2020-10-06 |
Janssen Biopharma, Inc. |
Modified oligonucleotides and methods of use
|
ES2893411T3
(es)
|
2016-09-15 |
2022-02-09 |
Hoffmann La Roche |
Procedimientos para realizar PCR multiplexada
|
JOP20190065A1
(ar)
|
2016-09-29 |
2019-03-28 |
Ionis Pharmaceuticals Inc |
مركبات وطرق لتقليل التعبير عن tau
|
US11400161B2
(en)
|
2016-10-06 |
2022-08-02 |
Ionis Pharmaceuticals, Inc. |
Method of conjugating oligomeric compounds
|
SG10201609048RA
(en)
|
2016-10-28 |
2018-05-30 |
Agency Science Tech & Res |
Antisense oligonucleotides
|
EP3532638A4
(en)
|
2016-10-31 |
2020-07-29 |
University of Massachusetts |
TARGETING MICROARN-101-3 P IN CARCINOTHERAPY
|
JOP20190104A1
(ar)
|
2016-11-10 |
2019-05-07 |
Ionis Pharmaceuticals Inc |
مركبات وطرق لتقليل التعبير عن atxn3
|
JP7033591B2
(ja)
|
2016-11-11 |
2022-03-10 |
ロシュ イノベーション センター コペンハーゲン エーエス |
治療用オリゴヌクレオチドの捕捉および検出
|
TWI788312B
(zh)
|
2016-11-23 |
2023-01-01 |
美商阿尼拉製藥公司 |
絲胺酸蛋白酶抑制因子A1 iRNA組成物及其使用方法
|
US11033570B2
(en)
|
2016-12-02 |
2021-06-15 |
Cold Spring Harbor Laboratory |
Modulation of Lnc05 expression
|
WO2018112320A1
(en)
|
2016-12-16 |
2018-06-21 |
Alnylam Pharmaceuticals, Inc. |
Methods for treating or preventing ttr-associated diseases using transthyretin (ttr) irna compositions
|
KR20190098748A
(ko)
|
2017-01-10 |
2019-08-22 |
애로우헤드 파마슈티컬스 인코포레이티드 |
알파-1 항트립신 (AAT) RNAi 작용제, AAT RNAi 작용제를 포함하는 조성물, 및 사용 방법
|
EP3568480A1
(en)
|
2017-01-13 |
2019-11-20 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides for modulating nfkb2 expression
|
WO2018130585A1
(en)
|
2017-01-13 |
2018-07-19 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides for modulating relb expression
|
WO2018130583A1
(en)
|
2017-01-13 |
2018-07-19 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides for modulating nfkb1 expression
|
US20200216845A1
(en)
|
2017-01-13 |
2020-07-09 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides for modulating rela expression
|
US20190338286A1
(en)
|
2017-01-13 |
2019-11-07 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides for modulating rel expression
|
US11572558B2
(en)
|
2017-02-06 |
2023-02-07 |
Nissan Chemical Corporation |
Single-stranded oligonucleotide
|
US11180756B2
(en)
|
2017-03-09 |
2021-11-23 |
Ionis Pharmaceuticals |
Morpholino modified oligomeric compounds
|
JP7306653B2
(ja)
|
2017-03-17 |
2023-07-11 |
国立大学法人千葉大学 |
構造強化されたS-TuDを用いた新規がん治療法
|
JOP20190215A1
(ar)
|
2017-03-24 |
2019-09-19 |
Ionis Pharmaceuticals Inc |
مُعدّلات التعبير الوراثي عن pcsk9
|
EP3603648A4
(en)
|
2017-03-29 |
2020-12-30 |
Shionogi & Co., Ltd |
COMPLEX OF NUCLEIC ACID MEDICINAL AND MULTI-BRANCHED LIPID
|
BR112019021852A2
(pt)
|
2017-04-18 |
2020-06-02 |
Alnylam Pharmaceuticals, Inc. |
Agente de rnai e uma vacina contra hbv, uso ou método e kit para tratamento
|
CA3062595A1
(en)
|
2017-05-10 |
2018-11-15 |
The Regents Of The University Of California |
Directed editing of cellular rna via nuclear delivery of crispr/cas9
|
US20190055564A1
(en)
|
2017-06-01 |
2019-02-21 |
F. Hoffmann-La Roche Ag |
Antisense oligonucleotides for modulating htra1 expression
|
EP3652316A4
(en)
|
2017-07-11 |
2021-04-07 |
Synthorx, Inc. |
INTEGRATION OF NON-NATURAL NUCLEOTIDES AND METHOD FOR THEREFORE
|
MX2020000387A
(es)
|
2017-07-13 |
2020-08-17 |
Univ Northwestern |
Método general y directo para preparar nanopartículas de estructura organometálica funcionalizadas con oligonucleotidos.
|
EP3660153A4
(en)
|
2017-07-26 |
2021-04-21 |
Nissan Chemical Corporation |
SINGLE-STRANDED OLIGONUCLEOTIDE
|
US11622993B2
(en)
|
2017-08-03 |
2023-04-11 |
Synthorx, Inc. |
Cytokine conjugates for the treatment of autoimmune diseases
|
WO2019030313A2
(en)
|
2017-08-11 |
2019-02-14 |
Roche Innovation Center Copenhagen A/S |
OLIGONUCLEOTIDES FOR MODULATION OF UBE3C EXPRESSION
|
CA3071033A1
(en)
|
2017-08-18 |
2019-02-21 |
Ionis Pharmaceuticals, Inc. |
Modulation of the notch signaling pathway for treatment of respiratory disorders
|
WO2019038228A1
(en)
|
2017-08-22 |
2019-02-28 |
Roche Innovation Center Copenhagen A/S |
OLIGONUCLEOTIDES FOR MODULATION OF TOM1 EXPRESSION
|
SI3673080T1
(sl)
|
2017-08-25 |
2024-03-29 |
Stoke Therapeutics, Inc. |
Protismiselni oligomeri za zdravljenje bolezenskih stanj in bolezni
|
KR20200044812A
(ko)
|
2017-08-31 |
2020-04-29 |
미쓰비시 타나베 파마 코퍼레이션 |
Il-33 안타고니스트를 포함하는 자궁내막증 치료제
|
KR102380264B1
(ko)
|
2017-08-31 |
2022-03-29 |
주식회사 씨젠 |
다이머-형성 프라이머 쌍을 이용한 구성요소의 성능 평가
|
US10517889B2
(en)
|
2017-09-08 |
2019-12-31 |
Ionis Pharmaceuticals, Inc. |
Modulators of SMAD7 expression
|
SG11202002149XA
(en)
|
2017-09-14 |
2020-04-29 |
Janssen Biopharma Inc |
Galnac derivatives
|
KR102345601B1
(ko)
|
2017-09-29 |
2021-12-30 |
주식회사 씨젠 |
Pto 절단 및 연장-의존적 연장 분석에 의한 타겟 핵산 서열의 검출
|
JP2021502059A
(ja)
|
2017-10-13 |
2021-01-28 |
ロシュ イノベーション センター コペンハーゲン エーエス |
部分的に立体定義されたオリゴヌクレオチドのサブライブラリーを使用することによる、アンチセンスオリゴヌクレオチドの、改良された立体定義されたホスホロチオエートオリゴヌクレオチド変異体を同定するための方法
|
MA52151A
(fr)
|
2017-10-16 |
2020-05-06 |
Hoffmann La Roche |
Molécule d'acide nucléique pour la réduction de l'arnm de papd5 et de papd7 pour le traitement d'une infection par l'hépatite b
|
EP3697904A1
(en)
|
2017-10-17 |
2020-08-26 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Combination treatment for cystic fibrosis
|
CA3078971A1
(en)
|
2017-11-01 |
2019-05-09 |
Alnylam Pharmaceuticals, Inc. |
Complement component c3 irna compositions and methods of use thereof
|
CA3079524A1
(en)
|
2017-11-03 |
2019-05-09 |
Interna Technologies B.V. |
Mirna molecule, equivalent, antagomir, or source thereof for treating and/or diagnosing a condition and/or a disease associated with neuronal deficiency or for neuronal (re)generation
|
TWI809004B
(zh)
|
2017-11-09 |
2023-07-21 |
美商Ionis製藥公司 |
用於降低snca表現之化合物及方法
|
WO2019099610A1
(en)
|
2017-11-16 |
2019-05-23 |
Alnylam Pharmaceuticals, Inc. |
Kisspeptin 1 (kiss1) irna compositions and methods of use thereof
|
EP3714054A1
(en)
|
2017-11-20 |
2020-09-30 |
Alnylam Pharmaceuticals, Inc. |
Serum amyloid p component (apcs) irna compositions and methods of use thereof
|
WO2019115416A2
(en)
|
2017-12-11 |
2019-06-20 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides for modulating fndc3b expression
|
WO2019115417A2
(en)
|
2017-12-12 |
2019-06-20 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides for modulating rb1 expression
|
WO2019118916A1
(en)
|
2017-12-14 |
2019-06-20 |
Ionis Pharmaceuticals, Inc. |
Conjugated antisense compounds and their use
|
WO2019118935A1
(en)
|
2017-12-14 |
2019-06-20 |
Casebia Therapeutics Limited Liability Partnership |
Novel rna-programmable endonuclease systems and their use in genome editing and other applications
|
EP3724355A1
(en)
|
2017-12-15 |
2020-10-21 |
Novartis AG |
Polya tail length analysis of rna by mass spectrometry
|
CA3086343A1
(en)
|
2017-12-18 |
2019-06-27 |
Alnylam Pharmaceuticals, Inc. |
High mobility group box-1 (hmgb1) irna compositions and methods of use thereof
|
WO2019121838A1
(en)
|
2017-12-21 |
2019-06-27 |
F. Hoffmann-La Roche Ag |
Companion diagnostic for htra1 rna antagonists
|
AU2018386524A1
(en)
|
2017-12-22 |
2020-07-02 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides comprising a phosphorodithioate internucleoside linkage
|
BR112020010090A2
(pt)
|
2017-12-22 |
2020-11-03 |
Roche Innovation Center Copenhagen A/S |
oligonucleotídeo gapmer, sal farmaceuticamente aceitável do mesmo, conjugado, composição farmacêutica e uso dos mesmos
|
EP3728590A1
(en)
|
2017-12-22 |
2020-10-28 |
Roche Innovation Center Copenhagen A/S |
Novel thiophosphoramidites
|
EP3737758A1
(en)
|
2018-01-10 |
2020-11-18 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides for modulating pias4 expression
|
SG11202006526YA
(en)
|
2018-01-12 |
2020-08-28 |
Bristol Myers Squibb Co |
Antisense oligonucleotides targeting alpha-synuclein and uses thereof
|
EP3737761A1
(en)
|
2018-01-12 |
2020-11-18 |
Bristol-Myers Squibb Company |
Antisense oligonucleotides targeting alpha-synuclein and uses thereof
|
US20210095275A1
(en)
|
2018-01-12 |
2021-04-01 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides for modulating gsk3b expression
|
EP3737759A1
(en)
|
2018-01-12 |
2020-11-18 |
Roche Innovation Center Copenhagen A/S |
Alpha-synuclein antisense oligonucleotides and uses thereof
|
CN111902537A
(zh)
|
2018-01-15 |
2020-11-06 |
Ionis制药公司 |
Dnm2表达的调节剂
|
US20210095276A1
(en)
|
2018-01-17 |
2021-04-01 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides for modulating erc1 expression
|
WO2019141723A1
(en)
|
2018-01-18 |
2019-07-25 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting srebp1
|
WO2019145386A1
(en)
|
2018-01-26 |
2019-08-01 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides for modulating csnk1d expression
|
KR20200108315A
(ko)
|
2018-02-09 |
2020-09-17 |
제넨테크, 인크. |
Tmem106b의 발현을 조절하기 위한 올리고뉴클레오티드
|
JP2021513508A
(ja)
|
2018-02-12 |
2021-05-27 |
インテアールエヌエー テクノロジーズ ビー.ヴイ.InteRNA Technologies B.V. |
抗がんマイクロrna及びその脂質製剤
|
EP3752612A4
(en)
|
2018-02-12 |
2021-11-10 |
Ionis Pharmaceuticals, Inc. |
MODIFIED COMPOUNDS AND USES THEREOF
|
KR20200140805A
(ko)
|
2018-02-21 |
2020-12-16 |
브리스톨-마이어스 스큅 컴퍼니 |
Camk2d 안티센스 올리고뉴클레오티드 및 그의 용도
|
MA52426A
(fr)
|
2018-02-26 |
2021-06-02 |
Synthorx Inc |
Conjugués d'il-15 et leurs utilisations
|
AU2019233612A1
(en)
|
2018-03-13 |
2020-09-10 |
Janssen Pharmaceutica Nv |
Modified oligonucleotides for use in treatment of tauopathies
|
EP3768834A1
(en)
|
2018-03-19 |
2021-01-27 |
CRISPR Therapeutics AG |
Novel rna-programmable endonuclease systems and uses thereof
|
JPWO2019182037A1
(ja)
|
2018-03-20 |
2021-03-11 |
国立大学法人東京工業大学 |
毒性が低減されたアンチセンスオリゴヌクレオチド
|
AU2019247645A1
(en)
|
2018-04-05 |
2020-10-15 |
Centre Leon Berard |
Use of FUBP1 inhibitors for treating hepatitis B virus infection
|
WO2019215067A1
(en)
|
2018-05-07 |
2019-11-14 |
Roche Innovation Center Copenhagen A/S |
Massively parallel discovery methods for oligonucleotide therapeutics
|
WO2019217459A1
(en)
|
2018-05-07 |
2019-11-14 |
Alnylam Pharmaceuticals, Inc. |
Extrahepatic delivery
|
EP3790971A1
(en)
|
2018-05-08 |
2021-03-17 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides for modulating myh7 expression
|
EP3799604A4
(en)
|
2018-05-09 |
2022-09-07 |
Ionis Pharmaceuticals, Inc. |
COMPOUNDS AND METHODS FOR REDUCING FXI EXPRESSION
|
TW202016304A
(zh)
|
2018-05-14 |
2020-05-01 |
美商阿尼拉製藥公司 |
血管收縮素原(AGT)iRNA組成物及其使用方法
|
JP2021524450A
(ja)
|
2018-05-18 |
2021-09-13 |
エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft |
マイクロrna関連疾患の処置のための薬学的組成物
|
WO2019226952A1
(en)
|
2018-05-24 |
2019-11-28 |
Valkyrie Pharmaceutics, Inc. |
Methods and formulations for the treatment of obesity and obesity-related metabolic diseases
|
WO2019224172A1
(en)
|
2018-05-25 |
2019-11-28 |
Roche Innovation Center Copenhagen A/S |
Novel process for making allofuranose from glucofuranose
|
JP7379387B2
(ja)
|
2018-06-05 |
2023-11-14 |
エフ. ホフマン-ラ ロシュ アーゲー |
Atxn2発現を制御するためのオリゴヌクレオチド
|
CA3103663A1
(en)
|
2018-06-18 |
2019-12-26 |
University Of Rochester |
Inhibition of re1-silencing transcription factor in the treatment of schizophrenia and other neuropsychiatric disorders
|
US20220062378A1
(en)
|
2018-06-21 |
2022-03-03 |
University Of Rochester |
Methods of treating or inhibiting onset of huntington's disease
|
WO2019243391A1
(en)
|
2018-06-21 |
2019-12-26 |
F. Hoffmann-La Roche Ag |
Hybridizing all-lna oligonucleotides
|
WO2020007772A1
(en)
|
2018-07-02 |
2020-01-09 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting gbp-1
|
WO2020007702A1
(en)
|
2018-07-02 |
2020-01-09 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting bcl2l11
|
WO2020007700A1
(en)
|
2018-07-02 |
2020-01-09 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting spi1
|
SG11202012759XA
(en)
|
2018-07-03 |
2021-01-28 |
Hoffmann La Roche |
Oligonucleotides for modulating tau expression
|
WO2020007889A1
(en)
|
2018-07-05 |
2020-01-09 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting stat1
|
WO2020007826A1
(en)
|
2018-07-05 |
2020-01-09 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting mbtps1
|
WO2020011743A1
(en)
|
2018-07-09 |
2020-01-16 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting mafb
|
WO2020011653A1
(en)
|
2018-07-09 |
2020-01-16 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting kynu
|
WO2020011869A2
(en)
|
2018-07-11 |
2020-01-16 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting tlr2
|
WO2020011745A2
(en)
|
2018-07-11 |
2020-01-16 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting cers6
|
WO2020011744A2
(en)
|
2018-07-11 |
2020-01-16 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting cers5
|
CA3106288A1
(en)
|
2018-07-13 |
2020-01-16 |
F.Hoffmann-La Roche Ag |
Oligonucleotides for modulating rtel1 expression
|
SG11202100077PA
(en)
|
2018-07-25 |
2021-02-25 |
Ionis Pharmaceuticals Inc |
Compounds and methods for reducing atxn2 expression
|
US20210308170A1
(en)
|
2018-07-27 |
2021-10-07 |
Osaka University |
Composition for suppression of aging, prevention, amelioration, or treatment of an age-related disease or symptom, or extension of lifespan
|
JP7470097B2
(ja)
|
2018-07-31 |
2024-04-17 |
ロシュ イノベーション センター コペンハーゲン エーエス |
ホスホロトリチオアートヌクレオシド間結合を含むオリゴヌクレオチド
|
MX2020013270A
(es)
|
2018-07-31 |
2021-02-18 |
Roche Innovation Ct Copenhagen As |
Oligonucleotidos que comprenden enlace internucleosidico de fosforotritioato.
|
EP3830301A1
(en)
|
2018-08-01 |
2021-06-09 |
Mammoth Biosciences, Inc. |
Programmable nuclease compositions and methods of use thereof
|
WO2020033791A1
(en)
|
2018-08-09 |
2020-02-13 |
Verseau Therapeutics, Inc. |
Oligonucleotide compositions for targeting ccr2 and csf1r and uses thereof
|
AU2019321375A1
(en)
|
2018-08-13 |
2021-03-11 |
Alnylam Pharmaceuticals, Inc. |
Hepatitis B virus (HBV) dsRNA agent compositions and methods of use thereof
|
EP3837367A1
(en)
|
2018-08-16 |
2021-06-23 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the lect2 gene
|
EA202190581A1
(ru)
|
2018-08-20 |
2021-07-13 |
Рогкон, Инк. |
Антисмысловые олигонуклеотиды, нацеленные на scn2a, для лечения энцефалопатии scn1a
|
WO2020038976A1
(en)
|
2018-08-23 |
2020-02-27 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting usp8
|
CN112585280A
(zh)
|
2018-08-23 |
2021-03-30 |
罗氏创新中心哥本哈根有限公司 |
微小rna-134生物标志物
|
WO2020038973A1
(en)
|
2018-08-23 |
2020-02-27 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting sptlc1
|
WO2020038971A1
(en)
|
2018-08-23 |
2020-02-27 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting vcan
|
WO2020043750A1
(en)
|
2018-08-28 |
2020-03-05 |
Roche Innovation Center Copenhagen A/S |
Neoantigen engineering using splice modulating compounds
|
EP3843845A4
(en)
|
2018-08-29 |
2022-05-11 |
University Of Massachusetts |
INHIBITION OF PROTEIN KINASE FOR THE TREATMENT OF FRIEDREICH'S ATAXIA
|
EP3620519A1
(en)
|
2018-09-04 |
2020-03-11 |
F. Hoffmann-La Roche AG |
Use of isolated milk extracellular vesicles for delivering oligonucleotides orally
|
EP3620520A1
(en)
|
2018-09-10 |
2020-03-11 |
Universidad del Pais Vasco |
Novel target to treat a metabolic disease in an individual
|
JP2022500442A
(ja)
|
2018-09-14 |
2022-01-04 |
ノースウェスタン ユニバーシティ |
Dnaとのタンパク質重合のプログラミング
|
US20210332367A1
(en)
|
2018-09-18 |
2021-10-28 |
Alnylam Pharmaceuticals, Inc. |
KETOHEXOKINASE (KHK) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
TW202023573A
(zh)
|
2018-09-19 |
2020-07-01 |
美商Ionis製藥公司 |
Pnpla3表現之調節劑
|
TW202028465A
(zh)
|
2018-09-28 |
2020-08-01 |
美商阿尼拉製藥公司 |
甲狀腺素運載蛋白(TTR)iRNA組成物及其治療或預防TTR相關眼部疾病之使用方法
|
EP3870700A1
(en)
|
2018-10-24 |
2021-09-01 |
Codiak BioSciences, Inc. |
Methods to improve potency of electroporation
|
US10913951B2
(en)
|
2018-10-31 |
2021-02-09 |
University of Pittsburgh—of the Commonwealth System of Higher Education |
Silencing of HNF4A-P2 isoforms with siRNA to improve hepatocyte function in liver failure
|
EP3873920A1
(en)
|
2018-11-01 |
2021-09-08 |
F. Hoffmann-La Roche AG |
Antisense oligonucleotides targeting tia1
|
TW202028222A
(zh)
|
2018-11-14 |
2020-08-01 |
美商Ionis製藥公司 |
Foxp3表現之調節劑
|
JOP20210108A1
(ar)
|
2018-11-15 |
2023-01-30 |
Ionis Pharmaceuticals Inc |
معدِّلات تعبير irf5
|
CN113039287A
(zh)
|
2018-11-16 |
2021-06-25 |
豪夫迈·罗氏有限公司 |
具有结合对的成员的涂覆有链霉亲和素的固相
|
TW202039841A
(zh)
|
2018-11-21 |
2020-11-01 |
美商Ionis製藥公司 |
用於減少朊病毒表現之化合物及方法
|
CN113166185A
(zh)
|
2018-11-22 |
2021-07-23 |
罗氏创新中心哥本哈根有限公司 |
作为立体限定的寡核苷酸合成中的活化剂的吡啶鎓盐
|
WO2020109343A1
(en)
|
2018-11-29 |
2020-06-04 |
F. Hoffmann-La Roche Ag |
Combination therapy for treatment of macular degeneration
|
WO2020109344A1
(en)
|
2018-11-29 |
2020-06-04 |
F. Hoffmann-La Roche Ag |
Occular administration device for antisense oligonucleotides
|
US20210332495A1
(en)
|
2018-12-06 |
2021-10-28 |
Northwestern University |
Protein Crystal Engineering Through DNA Hybridization Interactions
|
CN113728103A
(zh)
|
2018-12-11 |
2021-11-30 |
罗切斯特大学 |
治疗精神分裂症和其他神经精神病症的方法
|
KR20210104555A
(ko)
|
2018-12-17 |
2021-08-25 |
일루미나 케임브리지 리미티드 |
서열분석을 위한 프라이머 올리고뉴클레오타이드
|
EP3899035A1
(en)
|
2018-12-20 |
2021-10-27 |
F. Hoffmann-La Roche AG |
Detection of target nucleic acid by solid-phase molography
|
JP2022515744A
(ja)
|
2018-12-20 |
2022-02-22 |
プラクシス プレシジョン メディシンズ, インコーポレイテッド |
Kcnt1関連障害の治療のための組成物及び方法
|
EP4285929A3
(en)
|
2018-12-20 |
2024-03-06 |
Humabs Biomed SA |
Combination hbv therapy
|
CN113330118A
(zh)
|
2018-12-21 |
2021-08-31 |
勃林格殷格翰国际有限公司 |
靶向card9的反义寡核苷酸
|
EP3931313A2
(en)
|
2019-01-04 |
2022-01-05 |
Mammoth Biosciences, Inc. |
Programmable nuclease improvements and compositions and methods for nucleic acid amplification and detection
|
MX2021008628A
(es)
|
2019-01-16 |
2021-11-17 |
Genzyme Corp |
Composiciones de arni para serpinc1 y metodos de uso de las mismas.
|
CN113365607A
(zh)
|
2019-01-25 |
2021-09-07 |
豪夫迈·罗氏有限公司 |
用于口服药物递送的脂质囊泡
|
CA3128093A1
(en)
|
2019-01-31 |
2020-08-06 |
Ionis Pharmaceuticals, Inc. |
Modulators of yap1 expression
|
CN113660946A
(zh)
|
2019-02-06 |
2021-11-16 |
新索思股份有限公司 |
Il-2缀合物及其使用方法
|
US20230057355A1
(en)
|
2019-02-13 |
2023-02-23 |
University Of Rochester |
Gene networks that mediate remyelination of the human brain
|
MX2021009949A
(es)
|
2019-02-20 |
2021-09-21 |
Roche Innovation Ct Copenhagen As |
Fosforamiditas novedosas.
|
WO2020169695A1
(en)
|
2019-02-20 |
2020-08-27 |
Roche Innovation Center Copenhagen A/S |
Phosphonoacetate gapmer oligonucleotides
|
JP2022522430A
(ja)
|
2019-02-26 |
2022-04-19 |
ロシュ イノベーション センター コペンハーゲン エーエス |
オリゴヌクレオチドの製剤化方法
|
TW202045724A
(zh)
|
2019-02-27 |
2020-12-16 |
美商Ionis製藥公司 |
Malat1表現之調節劑
|
CN113507942A
(zh)
|
2019-03-05 |
2021-10-15 |
豪夫迈·罗氏有限公司 |
分子的细胞内靶向
|
CN113811607A
(zh)
|
2019-03-07 |
2021-12-17 |
加利福尼亚大学董事会 |
CRISPR-Cas效应子多肽和其使用方法
|
CA3132630A1
(en)
|
2019-03-12 |
2020-09-17 |
Crispr Therapeutics Ag |
Novel high fidelity rna-programmable endonuclease systems and uses thereof
|
US20220162607A1
(en)
|
2019-03-14 |
2022-05-26 |
Rena Therapeutics Inc. |
Nucleic acid complex for modulating ihh expression
|
WO2020191377A1
(en)
|
2019-03-21 |
2020-09-24 |
Codiak Biosciences, Inc. |
Extracellular vesicle conjugates and uses thereof
|
CN117431244A
(zh)
|
2019-03-29 |
2024-01-23 |
Ionis制药公司 |
用于调节ube3a-ats的化合物和方法
|
KR20210142699A
(ko)
|
2019-03-29 |
2021-11-25 |
미쓰비시 타나베 파마 코퍼레이션 |
Dux4의 발현을 조절하기 위한 화합물, 방법 및 의약조성물
|
CN113906139A
(zh)
|
2019-04-03 |
2022-01-07 |
百时美施贵宝公司 |
Angptl2反义寡核苷酸及其用途
|
CN113785060A
(zh)
|
2019-04-04 |
2021-12-10 |
豪夫迈·罗氏有限公司 |
用于调节atxn2表达的寡核苷酸
|
US11286485B2
(en)
|
2019-04-04 |
2022-03-29 |
Hoffmann-La Roche Inc. |
Oligonucleotides for modulating ATXN2 expression
|
JP2022529342A
(ja)
|
2019-04-16 |
2022-06-21 |
ロシュ イノベーション センター コペンハーゲン エーエス |
ヌクレオチドp(v)モノマーを調製するための新規の方法
|
CN113767108A
(zh)
|
2019-04-30 |
2021-12-07 |
罗氏创新中心哥本哈根有限公司 |
制备铼螯合mag3寡核苷酸的新方法
|
KR20220004675A
(ko)
|
2019-05-03 |
2022-01-11 |
다이서나 파마수이티컬, 인크. |
단축 센스 가닥을 갖는 이중 가닥 핵산 억제제 분자
|
KR20220036914A
(ko)
|
2019-05-13 |
2022-03-23 |
비르 바이오테크놀로지, 인코포레이티드 |
B형 간염 바이러스(hbv) 감염을 치료하기 위한 조성물 및 방법
|
CA3138915A1
(en)
|
2019-05-17 |
2020-11-26 |
Alnylam Pharmaceuticals, Inc. |
Oral delivery of oligonucleotides
|
TW202111123A
(zh)
|
2019-05-28 |
2021-03-16 |
美商Ionis製藥公司 |
用於減少fus 表現之化合物及方法
|
WO2020243644A1
(en)
|
2019-05-31 |
2020-12-03 |
Streck, Inc. |
Detection of antibiotic resistance genes
|
JP7155302B2
(ja)
|
2019-06-06 |
2022-10-18 |
エフ.ホフマン-ラ ロシュ アーゲー |
Atxn3を標的とするアンチセンスオリゴヌクレオチド
|
CN113939599A
(zh)
|
2019-06-07 |
2022-01-14 |
豪夫迈·罗氏有限公司 |
杂交全lna寡核苷酸
|
CA3143330A1
(en)
|
2019-06-14 |
2020-12-17 |
The Scripps Research Institute |
Reagents and methods for replication, transcription, and translation in semi-synthetic organisms
|
EP3988558A4
(en)
|
2019-06-19 |
2022-09-28 |
Yamasa Corporation |
CROSSLINKED NUCLEOSIDE INTERMEDIATE CRYSTAL AND METHOD FOR PRODUCTION THEREOF, AND METHOD FOR PRODUCTION OF CROSSLINKED NUCLEOSIDE AMIDITE
|
US20220251567A1
(en)
|
2019-07-10 |
2022-08-11 |
Inserm (Institut National De La Santè Et De La Recherche Médicale) |
Methods for the treatment of epilepsy
|
CA3144687A1
(en)
|
2019-07-18 |
2021-01-21 |
Steven A. Goldman |
Cell-type selective immunoprotection of cells
|
US11786546B2
(en)
|
2019-07-26 |
2023-10-17 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating GFAP
|
EP4005602A1
(en)
|
2019-07-30 |
2022-06-01 |
Shionogi & Co., Ltd |
Nucleic acid drug targeting murf1
|
WO2021022109A1
(en)
|
2019-08-01 |
2021-02-04 |
Alnylam Pharmaceuticals, Inc. |
SERPIN FAMILY F MEMBER 2 (SERPINF2) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
WO2021022108A2
(en)
|
2019-08-01 |
2021-02-04 |
Alnylam Pharmaceuticals, Inc. |
CARBOXYPEPTIDASE B2 (CPB2) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
WO2021030522A1
(en)
|
2019-08-13 |
2021-02-18 |
Alnylam Pharmaceuticals, Inc. |
SMALL RIBOSOMAL PROTEIN SUBUNIT 25 (RPS25) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF
|
US20230002764A1
(en)
|
2019-08-14 |
2023-01-05 |
Codiak Biosciences, Inc. |
Extracellular vesicle-aso constructs targeting cebp/beta
|
JP2022544289A
(ja)
|
2019-08-14 |
2022-10-17 |
コディアック バイオサイエンシーズ, インコーポレイテッド |
Stat6を標的とする細胞外小胞-aso構築物
|
CA3147701A1
(en)
|
2019-08-14 |
2021-02-18 |
Codiak Biosciences, Inc. |
Extracellular vesicles with antisense oligonucleotides targeting kras
|
WO2021030769A1
(en)
|
2019-08-14 |
2021-02-18 |
Codiak Biosciences, Inc. |
Extracellular vesicles with nras antisense oligonucleotides
|
EP4013876A1
(en)
|
2019-08-14 |
2022-06-22 |
Codiak BioSciences, Inc. |
Extracellular vesicle-nlrp3 antagonist
|
CA3145924A1
(en)
|
2019-08-14 |
2021-02-18 |
Yi Zhang |
Extracellular vesicle linked to molecules and uses thereof
|
CN114555621A
(zh)
|
2019-08-15 |
2022-05-27 |
Ionis制药公司 |
键修饰的寡聚化合物及其用途
|
CN114555128A
(zh)
|
2019-08-15 |
2022-05-27 |
新索思股份有限公司 |
采用il-2缀合物的免疫肿瘤学组合疗法
|
EP4017540A1
(en)
|
2019-08-23 |
2022-06-29 |
Synthorx, Inc. |
Il-15 conjugates and uses thereof
|
EP4025694A1
(en)
|
2019-09-03 |
2022-07-13 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the lect2 gene
|
KR20220061158A
(ko)
|
2019-09-10 |
2022-05-12 |
신톡스, 인크. |
자가면역질환을 치료하기 위한 il-2 접합체 및 사용 방법
|
WO2021062058A1
(en)
|
2019-09-25 |
2021-04-01 |
Codiak Biosciences, Inc. |
Sting agonist comprising exosomes for treating neuroimmunological disorders
|
WO2021067747A1
(en)
|
2019-10-04 |
2021-04-08 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for silencing ugt1a1 gene expression
|
CN114728017A
(zh)
|
2019-10-14 |
2022-07-08 |
阿斯利康(瑞典)有限公司 |
Pnpla3表达的调节剂
|
WO2021074657A1
(en)
|
2019-10-17 |
2021-04-22 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Combination treatment for cystic fibrosis
|
JPWO2021075538A1
(xx)
|
2019-10-18 |
2021-04-22 |
|
|
EP4045652A1
(en)
|
2019-10-18 |
2022-08-24 |
Alnylam Pharmaceuticals, Inc. |
Solute carrier family member irna compositions and methods of use thereof
|
KR20220084399A
(ko)
|
2019-10-22 |
2022-06-21 |
알닐람 파마슈티칼스 인코포레이티드 |
보체 성분 C3 iRNA 조성물 및 이의 사용 방법
|
WO2021087325A1
(en)
|
2019-11-01 |
2021-05-06 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for silencing dnajb1-prkaca fusion gene expression
|
AR120341A1
(es)
|
2019-11-01 |
2022-02-09 |
Alnylam Pharmaceuticals Inc |
COMPOSICIONES DE AGENTES DE ARNi CONTRA LA HUNTINGTINA (HTT) Y SUS MÉTODOS DE USO
|
MX2022005251A
(es)
|
2019-11-04 |
2022-06-08 |
Synthorx Inc |
Conjugados de interleuquina 10 y sus usos.
|
CN114945669A
(zh)
|
2019-11-06 |
2022-08-26 |
阿尔尼拉姆医药品有限公司 |
肝外递送
|
EP4055165A1
(en)
|
2019-11-06 |
2022-09-14 |
Alnylam Pharmaceuticals, Inc. |
Transthyretin (ttr) irna compositions and methods of use thereof for treating or preventing ttr-associated ocular diseases
|
PE20230179A1
(es)
|
2019-11-13 |
2023-02-01 |
Alnylam Pharmaceuticals Inc |
Metodos y composiciones para el tratamiento de un trastorno asociado con angiotensinogeno (agt)
|
US20230016983A1
(en)
|
2019-11-19 |
2023-01-19 |
lNSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) |
Antisense oligonucleotides and thier use for the treatment of cancer
|
EP4061945A1
(en)
|
2019-11-22 |
2022-09-28 |
Alnylam Pharmaceuticals, Inc. |
Ataxin3 (atxn3) rnai agent compositions and methods of use thereof
|
CN115335521A
(zh)
|
2019-11-27 |
2022-11-11 |
克里斯珀医疗股份公司 |
合成rna分子的方法
|
EP3831843A1
(en)
|
2019-12-08 |
2021-06-09 |
Royal College Of Surgeons In Ireland |
A hemostatic agent and uses thereof
|
AU2020401206A1
(en)
|
2019-12-11 |
2022-07-14 |
Intellia Therapeutics, Inc. |
Modified guide RNAs for gene editing
|
WO2021119226A1
(en)
|
2019-12-13 |
2021-06-17 |
Alnylam Pharmaceuticals, Inc. |
Human chromosome 9 open reading frame 72 (c9orf72) irna agent compositions and methods of use thereof
|
WO2021126734A1
(en)
|
2019-12-16 |
2021-06-24 |
Alnylam Pharmaceuticals, Inc. |
Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof
|
WO2021123074A1
(en)
|
2019-12-18 |
2021-06-24 |
F. Hoffmann-La Roche Ag |
Methods of sequencing by synthesis using a consecutive labeling scheme
|
WO2021122735A1
(en)
|
2019-12-19 |
2021-06-24 |
F. Hoffmann-La Roche Ag |
Use of sept9 inhibitors for treating hepatitis b virus infection
|
EP4077671A1
(en)
|
2019-12-19 |
2022-10-26 |
F. Hoffmann-La Roche AG |
Use of saraf inhibitors for treating hepatitis b virus infection
|
EP4077670A1
(en)
|
2019-12-19 |
2022-10-26 |
F. Hoffmann-La Roche AG |
Use of cops3 inhibitors for treating hepatitis b virus infection
|
WO2021122910A1
(en)
|
2019-12-19 |
2021-06-24 |
F. Hoffmann-La Roche Ag |
Use of sbds inhibitors for treating hepatitis b virus infection
|
EP4077668A1
(en)
|
2019-12-19 |
2022-10-26 |
F. Hoffmann-La Roche AG |
Use of scamp3 inhibitors for treating hepatitis b virus infection
|
TW202136510A
(zh)
|
2019-12-20 |
2021-10-01 |
瑞士商赫孚孟拉羅股份公司 |
用於抑制scn9a表現之增強型寡核苷酸
|
CA3163646A1
(en)
|
2019-12-24 |
2021-07-01 |
F. Hoffman-La Roche Ag |
Pharmaceutical combination of antiviral agents targeting hbv and/or an immune modulator for treatment of hbv
|
CA3163490A1
(en)
|
2019-12-24 |
2021-07-01 |
F. Hoffman-La Roche Ag |
Pharmaceutical combination of a therapeutic oligonucleotide targeting hbv and a tlr7 agonist for treatment of hbv
|
WO2021154941A1
(en)
|
2020-01-31 |
2021-08-05 |
Alnylam Pharmaceuticals, Inc. |
Complement component c5 irna compositions for use in the treatment of amyotrophic lateral sclerosis (als)
|
JPWO2021153747A1
(xx)
|
2020-01-31 |
2021-08-05 |
|
|
WO2021158810A1
(en)
|
2020-02-05 |
2021-08-12 |
Bristol-Myers Squibb Company |
Oligonucleotides for splice modulation of camk2d
|
WO2021163066A1
(en)
|
2020-02-10 |
2021-08-19 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for silencing vegf-a expression
|
AU2021224778A1
(en)
|
2020-02-18 |
2022-09-29 |
Alnylam Pharmaceuticals, Inc. |
Apolipoprotein C3 (APOC3) iRNA compositions and methods of use thereof
|
US20220064638A1
(en)
|
2020-02-28 |
2022-03-03 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating smn2
|
WO2021170697A1
(en)
|
2020-02-28 |
2021-09-02 |
F. Hoffmann-La Roche Ag |
Oligonucleotides for modulating cd73 exon 7 splicing
|
WO2021177418A1
(ja)
|
2020-03-04 |
2021-09-10 |
日産化学株式会社 |
Calm2のアンチセンスオリゴヌクレオチド
|
WO2021178607A1
(en)
|
2020-03-05 |
2021-09-10 |
Alnylam Pharmaceuticals, Inc. |
Complement component c3 irna compositions and methods of use thereof for treating or preventing complement component c3-associated diseases
|
JP2023516095A
(ja)
|
2020-03-06 |
2023-04-17 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
ケトヘキソキナーゼ(KHK)iRNA組成物およびその使用方法
|
JP2023516748A
(ja)
|
2020-03-06 |
2023-04-20 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
トランスサイレチン(ttr)の発現を阻害するための組成物および方法
|
WO2021184020A1
(en)
|
2020-03-13 |
2021-09-16 |
Codiak Biosciences, Inc. |
Methods of treating neuroinflammation
|
WO2021184021A1
(en)
|
2020-03-13 |
2021-09-16 |
Codiak Biosciences, Inc. |
Extracellular vesicle-aso constructs targeting pmp22
|
WO2021188611A1
(en)
|
2020-03-18 |
2021-09-23 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for treating subjects having a heterozygous alanine-glyoxylate aminotransferase gene (agxt) variant
|
TW202204615A
(zh)
|
2020-03-26 |
2022-02-01 |
美商阿尼拉製藥公司 |
冠狀病毒iRNA組成物及其使用方法
|
WO2021202443A2
(en)
|
2020-03-30 |
2021-10-07 |
Alnylam Pharmaceucticals, Inc. |
Compositions and methods for silencing dnajc15 gene expression
|
JP2023520201A
(ja)
|
2020-03-31 |
2023-05-16 |
ヤンセン バイオファーマ インク. |
オリゴヌクレオチド及び関連化合物の合成
|
EP4133078A1
(en)
|
2020-04-06 |
2023-02-15 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for silencing myoc expression
|
WO2021206922A1
(en)
|
2020-04-07 |
2021-10-14 |
Alnylam Pharmaceuticals, Inc. |
Transmembrane serine protease 2 (tmprss2) irna compositions and methods of use thereof
|
TW202204617A
(zh)
|
2020-04-07 |
2022-02-01 |
美商艾爾妮蘭製藥公司 |
用於靜默scn9a表現之組合物及方法
|
EP4133076A1
(en)
|
2020-04-07 |
2023-02-15 |
Alnylam Pharmaceuticals, Inc. |
Angiotensin-converting enzyme 2 (ace2) irna compositions and methods of use thereof
|
EP4143319A1
(en)
|
2020-04-27 |
2023-03-08 |
Alnylam Pharmaceuticals, Inc. |
Apolipoprotein e (apoe) irna agent compositions and methods of use thereof
|
BR112022021136A2
(pt)
|
2020-04-30 |
2022-11-29 |
Alnylam Pharmaceuticals Inc |
Composições de irna de fator b de complemento (cfb) e métodos de uso das mesmas
|
WO2021231210A1
(en)
|
2020-05-11 |
2021-11-18 |
Genentech, Inc. |
Complement component c1r inhibitors for treating a neurological disease, and related compositions, systems and methods of using same
|
CN115698290A
(zh)
|
2020-05-11 |
2023-02-03 |
基因泰克公司 |
用于治疗神经系统疾病的补体组分4抑制剂以及使用它们的相关组合物、系统和方法
|
JP2023525799A
(ja)
|
2020-05-11 |
2023-06-19 |
ストーク セラピューティクス,インク. |
状態及び疾患の治療のためのopa1アンチセンスオリゴマー
|
JP2023527684A
(ja)
|
2020-05-11 |
2023-06-30 |
ジェネンテック, インコーポレイテッド |
神経疾患を治療するための補体成分c1s阻害剤、並びにそれを使用する関連組成物、システム及び方法
|
CN115667513A
(zh)
|
2020-05-12 |
2023-01-31 |
田边三菱制药株式会社 |
用于调节Ataxin 3表达的化合物、方法和药物组合物
|
US20210388357A1
(en)
|
2020-05-13 |
2021-12-16 |
Hoffmann-La Roche Inc. |
Oligonucleotide agonists targeting progranulin
|
WO2021231673A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of leucine rich repeat kinase 2 (lrrk2)
|
WO2021231679A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of gap junction protein beta 2 (gjb2)
|
WO2021231698A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of argininosuccinate lyase (asl)
|
WO2021231692A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of otoferlin (otof)
|
WO2021231685A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of transmembrane channel-like protein 1 (tmc1)
|
EP4150076A1
(en)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of methyl-cpg binding protein 2 (mecp2)
|
WO2021231691A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of retinoschisin 1 (rsi)
|
WO2021231675A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of argininosuccinate synthetase (ass1)
|
WO2021237097A1
(en)
|
2020-05-21 |
2021-11-25 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting marc1 gene expression
|
JP2023526096A
(ja)
|
2020-05-22 |
2023-06-20 |
エフ. ホフマン-ラ ロシュ アーゲー |
Card9のスプライス調節のためのオリゴヌクレオチド
|
US11408000B2
(en)
|
2020-06-03 |
2022-08-09 |
Triplet Therapeutics, Inc. |
Oligonucleotides for the treatment of nucleotide repeat expansion disorders associated with MSH3 activity
|
WO2021249993A1
(en)
|
2020-06-09 |
2021-12-16 |
Roche Innovation Center Copenhagen A/S |
Guanosine analogues for use in therapeutic polynucleotides
|
EP4162050A1
(en)
|
2020-06-09 |
2023-04-12 |
Alnylam Pharmaceuticals, Inc. |
Rnai compositions and methods of use thereof for delivery by inhalation
|
CA3184289A1
(en)
|
2020-06-18 |
2021-12-23 |
Alnylam Pharmaceuticals, Inc. |
Xanthine dehydrogenase (xdh) irna compositions and methods of use thereof
|
KR20230042023A
(ko)
|
2020-06-24 |
2023-03-27 |
비르 바이오테크놀로지, 인코포레이티드 |
조작된 b형 간염 바이러스 중화 항체 및 이의 용도
|
AU2021296622A1
(en)
|
2020-06-25 |
2023-02-23 |
Synthorx, Inc. |
Immuno oncology combination therapy with IL-2 conjugates and anti-EGFR antibodies
|
AR122731A1
(es)
|
2020-06-26 |
2022-10-05 |
Hoffmann La Roche |
Oligonucleótidos mejorados para modular la expresión de fubp1
|
EP4179091A1
(en)
|
2020-07-10 |
2023-05-17 |
Institut National De La Sante Et De La Recherche Medicale - Inserm |
Methods and compositions for treating epilepsy
|
WO2022011214A1
(en)
|
2020-07-10 |
2022-01-13 |
Alnylam Pharmaceuticals, Inc. |
Circular sirnas
|
US20230235315A1
(en)
|
2020-07-10 |
2023-07-27 |
Horizon Discovery Limited |
Method for producing genetically modified cells
|
WO2022018155A1
(en)
|
2020-07-23 |
2022-01-27 |
F. Hoffmann-La Roche Ag |
Lna oligonucleotides for splice modulation of stmn2
|
CN116209761A
(zh)
|
2020-07-23 |
2023-06-02 |
豪夫迈·罗氏有限公司 |
靶向rna结合蛋白位点的寡核苷酸
|
WO2022038211A2
(en)
|
2020-08-21 |
2022-02-24 |
F. Hoffmann-La Roche Ag |
Use of a1cf inhibitors for treating hepatitis b virus infection
|
TW202227102A
(zh)
|
2020-09-22 |
2022-07-16 |
瑞典商阿斯特捷利康公司 |
治療脂肪肝病之方法
|
EP4217489A1
(en)
|
2020-09-24 |
2023-08-02 |
Alnylam Pharmaceuticals, Inc. |
Dipeptidyl peptidase 4 (dpp4) irna compositions and methods of use thereof
|
JP2023544413A
(ja)
|
2020-10-05 |
2023-10-23 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
Gタンパク質共役受容体75(GPR75)iRNA組成物およびその使用方法
|
WO2022076596A1
(en)
|
2020-10-06 |
2022-04-14 |
Codiak Biosciences, Inc. |
Extracellular vesicle-aso constructs targeting stat6
|
CA3194880A1
(en)
|
2020-10-09 |
2022-04-14 |
Carolina E. CAFFARO |
Immuno oncology therapies with il-2 conjugates
|
EP4225376A1
(en)
|
2020-10-09 |
2023-08-16 |
Synthorx, Inc. |
Immuno oncology combination therapy with il-2 conjugates and pembrolizumab
|
EP4232581A1
(en)
|
2020-10-21 |
2023-08-30 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for treating primary hyperoxaluria
|
EP4232582A1
(en)
|
2020-10-23 |
2023-08-30 |
Alnylam Pharmaceuticals, Inc. |
Mucin 5b (muc5b) irna compositions and methods of use thereof
|
AU2021380809A1
(en)
|
2020-11-13 |
2023-06-22 |
Alnylam Pharmaceuticals, Inc. |
COAGULATION FACTOR V (F5) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
EP4136092A4
(en)
|
2020-11-18 |
2023-10-11 |
Ionis Pharmaceuticals, Inc. |
COMPOUNDS AND METHODS FOR MODULATING ANGIOTENSINOGEN EXPRESSION
|
AU2021384225A1
(en)
|
2020-11-18 |
2023-07-06 |
Lemba Bv |
Umlilo antisense transcription inhibitors
|
WO2022106695A1
(en)
|
2020-11-23 |
2022-05-27 |
Alpha Anomeric Sas |
Nucleic acid duplexes
|
EP4256053A1
(en)
|
2020-12-01 |
2023-10-11 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for inhibition of hao1 (hydroxyacid oxidase 1 (glycolate oxidase)) gene expression
|
WO2022117747A2
(en)
|
2020-12-03 |
2022-06-09 |
F. Hoffmann-La Roche Ag |
Antisense oligonucleotides targeting atxn3
|
WO2022117745A1
(en)
|
2020-12-03 |
2022-06-09 |
F. Hoffmann-La Roche Ag |
Antisense oligonucleotides targeting atxn3
|
EP4259795A1
(en)
|
2020-12-08 |
2023-10-18 |
Alnylam Pharmaceuticals, Inc. |
Coagulation factor x (f10) irna compositions and methods of use thereof
|
EP4259642A1
(en)
|
2020-12-08 |
2023-10-18 |
F. Hoffmann-La Roche AG |
Novel synthesis of phosphorodithioate oligonucleotides
|
GB2603454A
(en)
|
2020-12-09 |
2022-08-10 |
Ucl Business Ltd |
Novel therapeutics for the treatment of neurodegenerative disorders
|
JPWO2022124410A1
(xx)
|
2020-12-11 |
2022-06-16 |
|
|
TW202229553A
(zh)
|
2020-12-18 |
2022-08-01 |
瑞士商赫孚孟拉羅股份公司 |
靶向顆粒蛋白前體之反義寡核苷酸
|
CN116601308A
(zh)
|
2020-12-22 |
2023-08-15 |
豪夫迈·罗氏有限公司 |
使用大斯托克斯位移荧光染料进行多重实时pcr的方法
|
JP2024501662A
(ja)
|
2020-12-22 |
2024-01-15 |
エフ. ホフマン-ラ ロシュ アーゲー |
Xbp1を標的とするオリゴヌクレオチド
|
EP4271695A2
(en)
|
2020-12-31 |
2023-11-08 |
Alnylam Pharmaceuticals, Inc. |
2'-modified nucleoside based oligonucleotide prodrugs
|
CA3207125A1
(en)
|
2020-12-31 |
2022-07-07 |
Alnylam Pharmaceuticals, Inc. |
Cyclic-disulfide modified phosphate based oligonucleotide prodrugs
|
EP4274896A1
(en)
|
2021-01-05 |
2023-11-15 |
Alnylam Pharmaceuticals, Inc. |
Complement component 9 (c9) irna compositions and methods of use thereof
|
TW202246500A
(zh)
|
2021-02-02 |
2022-12-01 |
瑞士商赫孚孟拉羅股份公司 |
用於抑制 rtel1 表現之增強型寡核苷酸
|
CA3210763A1
(en)
|
2021-02-12 |
2022-08-18 |
Alnylam Pharmaceuticals, Inc. |
Superoxide dismutase 1 (sod1) irna compositions and methods of use thereof for treating or preventing superoxide dismutase 1- (sod1-) associated neurodegenerative diseases
|
TW202245843A
(zh)
|
2021-02-12 |
2022-12-01 |
美商欣爍克斯公司 |
Il-2接合物及西米普利單抗(cemiplimab)之皮膚癌組合療法
|
TW202302148A
(zh)
|
2021-02-12 |
2023-01-16 |
美商欣爍克斯公司 |
使用il-2接合物和抗pd-1抗體或其抗原結合片段的肺癌組合療法
|
IL305171A
(en)
|
2021-02-17 |
2023-10-01 |
Lonza Sales Ag |
EXTRACELLULAR VESILE-NLRP3 antagonist
|
KR20230146603A
(ko)
|
2021-02-17 |
2023-10-19 |
론자 세일즈 아게 |
최적화 링커와 고정 모이어티를 통해 생물학적 활성 분자에 연결된 세포외 소포체
|
EP4298220A1
(en)
|
2021-02-25 |
2024-01-03 |
Alnylam Pharmaceuticals, Inc. |
Prion protein (prnp) irna compositions and methods of use thereof
|
TW202302847A
(zh)
|
2021-02-26 |
2023-01-16 |
美商艾拉倫製藥股份有限公司 |
己酮糖激酶(KHK)iRNA組成物及其使用方法
|
KR20230150843A
(ko)
|
2021-03-04 |
2023-10-31 |
알닐람 파마슈티칼스 인코포레이티드 |
안지오포이에틴-유사 3(ANGPTL3) iRNA 조성물 및 이의 사용 방법
|
US20220288181A1
(en)
|
2021-03-12 |
2022-09-15 |
Northwestern University |
Antiviral vaccines using spherical nucleic acids
|
EP4305169A1
(en)
|
2021-03-12 |
2024-01-17 |
Alnylam Pharmaceuticals, Inc. |
Glycogen synthase kinase 3 alpha (gsk3a) irna compositions and methods of use thereof
|
US20220290221A1
(en)
|
2021-03-15 |
2022-09-15 |
Roche Molecular Systems, Inc. |
Compositions and methods for detecting severe acute respiratory syndrome coronavirus 2 (sars-cov-2) variants having spike protein mutations
|
KR20230162024A
(ko)
|
2021-03-29 |
2023-11-28 |
알닐람 파마슈티칼스 인코포레이티드 |
헌팅틴(HTT) iRNA 제제 조성물 및 이의 사용 방법
|
IL307298A
(en)
|
2021-03-31 |
2023-11-01 |
Entrada Therapeutics Inc |
Cell-penetrating circular peptides
|
EP4314293A1
(en)
|
2021-04-01 |
2024-02-07 |
Alnylam Pharmaceuticals, Inc. |
Proline dehydrogenase 2 (prodh2) irna compositions and methods of use thereof
|
CA3213989A1
(en)
|
2021-04-01 |
2022-10-06 |
Conlin O'NEIL |
Extracellular vesicle compositions
|
WO2022231999A1
(en)
|
2021-04-26 |
2022-11-03 |
Alnylam Pharmaceuticals, Inc. |
Transmembrane protease, serine 6 (tmprss6) irna compositions and methods of use thereof
|
WO2022232343A1
(en)
|
2021-04-29 |
2022-11-03 |
Alnylam Pharmaceuticals, Inc. |
Signal transducer and activator of transcription factor 6 (stat6) irna compositions and methods of use thereof
|
WO2022240721A1
(en)
|
2021-05-10 |
2022-11-17 |
Entrada Therapeutics, Inc. |
Compositions and methods for modulating interferon regulatory factor-5 (irf-5) activity
|
WO2022240760A2
(en)
|
2021-05-10 |
2022-11-17 |
Entrada Therapeutics, Inc. |
COMPOSITIONS AND METHODS FOR MODULATING mRNA SPLICING
|
CA3218805A1
(en)
|
2021-05-10 |
2022-11-17 |
Ziqing QIAN |
Compositions and methods for intracellular therapeutics
|
WO2022245583A1
(en)
|
2021-05-18 |
2022-11-24 |
Alnylam Pharmaceuticals, Inc. |
Sodium-glucose cotransporter-2 (sglt2) irna compositions and methods of use thereof
|
EP4341405A1
(en)
|
2021-05-20 |
2024-03-27 |
Korro Bio, Inc. |
Methods and compositions for adar-mediated editing
|
CN117412773A
(zh)
|
2021-05-31 |
2024-01-16 |
瑞纳治疗公司 |
配体结合核酸复合物
|
WO2022256283A2
(en)
|
2021-06-01 |
2022-12-08 |
Korro Bio, Inc. |
Methods for restoring protein function using adar
|
WO2022256395A1
(en)
|
2021-06-02 |
2022-12-08 |
Alnylam Pharmaceuticals, Inc. |
Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof
|
EP4346904A1
(en)
|
2021-06-03 |
2024-04-10 |
Synthorx, Inc. |
Head and neck cancer combination therapy comprising an il-2 conjugate and cetuximab
|
AR126000A1
(es)
|
2021-06-04 |
2023-08-30 |
Alnylam Pharmaceuticals Inc |
Agentes de arni del marco de lectura abierto 72 del cromosoma 9 humano (c9orf72), composiciones y métodos de uso de los mismos
|
AU2022284878A1
(en)
|
2021-06-04 |
2024-01-18 |
Translate Bio, Inc. |
Assay for quantitative assessment of mrna capping efficiency
|
AU2022288115A1
(en)
|
2021-06-08 |
2023-12-07 |
F. Hoffmann-La Roche Ag |
Oligonucleotide progranulin agonists
|
EP4351541A2
(en)
|
2021-06-08 |
2024-04-17 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for treating or preventing stargardt's disease and/or retinal binding protein 4 (rbp4)-associated disorders
|
TW202317764A
(zh)
|
2021-06-10 |
2023-05-01 |
美商英特利亞醫療公司 |
用於基因編輯之包含內部連接子之經修飾引導rna
|
EP4101928A1
(en)
|
2021-06-11 |
2022-12-14 |
Bayer AG |
Type v rna programmable endonuclease systems
|
EP4352214A1
(en)
|
2021-06-11 |
2024-04-17 |
Bayer AG |
Type v rna programmable endonuclease systems
|
KR20240037226A
(ko)
|
2021-06-22 |
2024-03-21 |
아큐라스템 인코포레이티드 |
Pikfyve 안티센스 올리고뉴클레오티드
|
KR20240038967A
(ko)
|
2021-06-23 |
2024-03-26 |
엔트라다 테라퓨틱스, 인크. |
Cug 반복을 표적화하기 위한 안티센스 화합물 및 방법
|
US20230194709A9
(en)
|
2021-06-29 |
2023-06-22 |
Seagate Technology Llc |
Range information detection using coherent pulse sets with selected waveform characteristics
|
WO2023278410A1
(en)
|
2021-06-29 |
2023-01-05 |
Korro Bio, Inc. |
Methods and compositions for adar-mediated editing
|
CA3225469A1
(en)
|
2021-06-30 |
2023-01-05 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for treating an angiotensinogen- (agt-) associated disorder
|
WO2023283403A2
(en)
|
2021-07-09 |
2023-01-12 |
Alnylam Pharmaceuticals, Inc. |
Bis-rnai compounds for cns delivery
|
WO2023003805A1
(en)
|
2021-07-19 |
2023-01-26 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for treating subjects having or at risk of developing a non-primary hyperoxaluria disease or disorder
|
CA3227115A1
(en)
|
2021-07-21 |
2023-01-26 |
Wen-Hsuan Chang |
Unc13a antisense oligonucleotides
|
IL309897A
(en)
|
2021-07-21 |
2024-03-01 |
Alnylam Pharmaceuticals Inc |
Target gene IRNA compositions associated with a metabolic disorder and methods of using them
|
KR20240037293A
(ko)
|
2021-07-23 |
2024-03-21 |
알닐람 파마슈티칼스 인코포레이티드 |
베타-카테닌(CTNNB1) iRNA 조성물 및 이의 사용 방법
|
WO2023009687A1
(en)
|
2021-07-29 |
2023-02-02 |
Alnylam Pharmaceuticals, Inc. |
3-hydroxy-3-methylglutaryl-coa reductase (hmgcr) irna compositions and methods of use thereof
|
AU2022323090A1
(en)
|
2021-08-03 |
2024-02-01 |
Alnylam Pharmaceuticals, Inc. |
Transthyretin (ttr) irna compositions and methods of use thereof
|
WO2023014765A1
(en)
|
2021-08-04 |
2023-02-09 |
Alnylam Pharmaceuticals, Inc. |
iRNA COMPOSITIONS AND METHODS FOR SILENCING ANGIOTENSINOGEN (AGT)
|
TW202334413A
(zh)
|
2021-08-13 |
2023-09-01 |
美商艾拉倫製藥股份有限公司 |
第十二因子(F12)iRNA組成物及其使用方法
|
WO2023021046A1
(en)
|
2021-08-16 |
2023-02-23 |
Vib Vzw |
Oligonucleotides for modulating synaptogyrin-3 expression
|
IL311139A
(en)
|
2021-09-01 |
2024-04-01 |
Entrada Therapeutics Inc |
Compounds and methods for skipping exon 44 in Duchenne muscular dystrophy
|
WO2023034870A2
(en)
|
2021-09-01 |
2023-03-09 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for reducing dmpk expression
|
EP4144841A1
(en)
|
2021-09-07 |
2023-03-08 |
Bayer AG |
Novel small rna programmable endonuclease systems with impoved pam specificity and uses thereof
|
WO2023043280A1
(ko)
|
2021-09-17 |
2023-03-23 |
주식회사 씨젠 |
합성 비자연 염기를 포함하는 태그 올리고뉴클레오타이드를 이용한 타겟 핵산 서열의 검출
|
WO2023044370A2
(en)
|
2021-09-17 |
2023-03-23 |
Alnylam Pharmaceuticals, Inc. |
Irna compositions and methods for silencing complement component 3 (c3)
|
CA3232420A1
(en)
|
2021-09-20 |
2023-03-23 |
Alnylam Pharmaceuticals, Inc. |
Inhibin subunit beta e (inhbe) modulator compositions and methods of use thereof
|
WO2023052317A1
(en)
|
2021-09-29 |
2023-04-06 |
F. Hoffmann-La Roche Ag |
Rna editing
|
AU2022364838A1
(en)
|
2021-10-15 |
2024-04-11 |
Alnylam Pharmaceuticals, Inc. |
Extra-hepatic delivery irna compositions and methods of use thereof
|
CA3234835A1
(en)
|
2021-10-22 |
2023-04-27 |
Korro Bio, Inc. |
Methods and compositions for disrupting nrf2-keap1 protein interaction by adar mediated rna editing
|
TW202333749A
(zh)
|
2021-10-29 |
2023-09-01 |
美商艾拉倫製藥股份有限公司 |
補體因子b(cfb)irna組成物及其使用方法
|
WO2023076450A2
(en)
|
2021-10-29 |
2023-05-04 |
Alnylam Pharmaceuticals, Inc. |
HUNTINGTIN (HTT) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF
|
WO2023078883A1
(en)
|
2021-11-03 |
2023-05-11 |
F. Hoffmann-La Roche Ag |
Oligonucleotides for modulating apolipoprotein e4 expression
|
WO2023086292A2
(en)
|
2021-11-10 |
2023-05-19 |
University Of Rochester |
Gata4-targeted therapeutics for treatment of cardiac hypertrophy
|
WO2023086295A2
(en)
|
2021-11-10 |
2023-05-19 |
University Of Rochester |
Antisense oligonucleotides for modifying protein expression
|
WO2023083906A2
(en)
|
2021-11-11 |
2023-05-19 |
F. Hoffmann-La Roche Ag |
Pharmaceutical combinations for treatment of hbv
|
WO2023104693A1
(en)
|
2021-12-07 |
2023-06-15 |
F. Hoffmann-La Roche Ag |
Antisense oligonucleotides targeting actl6b
|
GB202117758D0
(en)
|
2021-12-09 |
2022-01-26 |
Ucl Business Ltd |
Therapeutics for the treatment of neurodegenerative disorders
|
WO2023111336A1
(en)
|
2021-12-17 |
2023-06-22 |
F. Hoffmann-La Roche Ag |
Oligonucleotide gba agonists
|
WO2023111210A1
(en)
|
2021-12-17 |
2023-06-22 |
F. Hoffmann-La Roche Ag |
Combination of oligonucleotides for modulating rtel1 and fubp1
|
WO2023122573A1
(en)
|
2021-12-20 |
2023-06-29 |
Synthorx, Inc. |
Head and neck cancer combination therapy comprising an il-2 conjugate and pembrolizumab
|
WO2023117738A1
(en)
|
2021-12-20 |
2023-06-29 |
F. Hoffmann-La Roche Ag |
Threose nucleic acid antisense oligonucleotides and methods thereof
|
WO2023118150A1
(en)
|
2021-12-22 |
2023-06-29 |
Royal College Of Surgeons In Ireland |
A conjugate for use in localising a molecule to the vascular endothelium.
|
WO2023122762A1
(en)
|
2021-12-22 |
2023-06-29 |
Camp4 Therapeutics Corporation |
Modulation of gene transcription using antisense oligonucleotides targeting regulatory rnas
|
WO2023122750A1
(en)
|
2021-12-23 |
2023-06-29 |
Synthorx, Inc. |
Cancer combination therapy with il-2 conjugates and cetuximab
|
WO2023118068A1
(en)
|
2021-12-23 |
2023-06-29 |
Bayer Aktiengesellschaft |
Novel small type v rna programmable endonuclease systems
|
WO2023141507A1
(en)
|
2022-01-20 |
2023-07-27 |
Genentech, Inc. |
Antisense oligonucleotides for modulating tmem106b expression
|
WO2023141314A2
(en)
|
2022-01-24 |
2023-07-27 |
Alnylam Pharmaceuticals, Inc. |
Heparin sulfate biosynthesis pathway enzyme irna agent compositions and methods of use thereof
|
WO2023150553A1
(en)
|
2022-02-01 |
2023-08-10 |
University Of Rochester |
Gpr17 promoter-based targeting and transduction of glial progenitor cells
|
WO2023152369A1
(en)
|
2022-02-14 |
2023-08-17 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Nucleic acid mir-9 inhibitor for the treatment of cystic fibrosis
|
WO2023156652A1
(en)
|
2022-02-21 |
2023-08-24 |
F. Hoffmann-La Roche Ag |
Antisense oligonucleotide
|
WO2023212625A1
(en)
|
2022-04-28 |
2023-11-02 |
AcuraStem Incorporated |
Syf2 antisense oligonucleotides
|
WO2023217890A1
(en)
|
2022-05-10 |
2023-11-16 |
F. Hoffmann-La Roche Ag |
Antisense oligonucleotides targeting cfp-elk1 intergene region
|
WO2023220744A2
(en)
|
2022-05-13 |
2023-11-16 |
Alnylam Pharmaceuticals, Inc. |
Single-stranded loop oligonucleotides
|
WO2023222858A1
(en)
|
2022-05-18 |
2023-11-23 |
F. Hoffmann-La Roche Ag |
Improved oligonucleotides targeting rna binding protein sites
|
WO2023237587A1
(en)
|
2022-06-10 |
2023-12-14 |
Bayer Aktiengesellschaft |
Novel small type v rna programmable endonuclease systems
|
WO2023240277A2
(en)
|
2022-06-10 |
2023-12-14 |
Camp4 Therapeutics Corporation |
Methods of modulating progranulin expression using antisense oligonucleotides targeting regulatory rnas
|
WO2023242324A1
(en)
|
2022-06-17 |
2023-12-21 |
F. Hoffmann-La Roche Ag |
Antisense oligonucleotides for targeting progranulin
|
WO2024006999A2
(en)
|
2022-06-30 |
2024-01-04 |
Alnylam Pharmaceuticals, Inc. |
Cyclic-disulfide modified phosphate based oligonucleotide prodrugs
|
WO2024017990A1
(en)
|
2022-07-21 |
2024-01-25 |
Institut National de la Santé et de la Recherche Médicale |
Methods and compositions for treating chronic pain disorders
|
WO2024040041A1
(en)
|
2022-08-15 |
2024-02-22 |
Dicerna Pharmaceuticals, Inc. |
Regulation of activity of rnai molecules
|
WO2024039776A2
(en)
|
2022-08-18 |
2024-02-22 |
Alnylam Pharmaceuticals, Inc. |
Universal non-targeting sirna compositions and methods of use thereof
|
EP4332221A1
(en)
|
2022-08-29 |
2024-03-06 |
Roche Innovation Center Copenhagen A/S |
Threose nucleic acid antisense oligonucleotides and methods thereof
|
WO2024050261A1
(en)
|
2022-08-29 |
2024-03-07 |
University Of Rochester |
Antisense oligonucleotide-based anti-fibrotic therapeutics
|
WO2024052403A1
(en)
|
2022-09-06 |
2024-03-14 |
F. Hoffmann-La Roche Ag |
Double-stranded rna molecule for administration to the eye
|
WO2024059165A1
(en)
|
2022-09-15 |
2024-03-21 |
Alnylam Pharmaceuticals, Inc. |
17b-hydroxysteroid dehydrogenase type 13 (hsd17b13) irna compositions and methods of use thereof
|
WO2024073732A1
(en)
|
2022-09-30 |
2024-04-04 |
Alnylam Pharmaceuticals, Inc. |
Modified double-stranded rna agents
|
WO2024073042A1
(en)
|
2022-09-30 |
2024-04-04 |
Entrada Therapeutics, Inc. |
Ocular delivery of therapeutic agents
|