EA201591286A1 - Количественная оценка эффективности кэп матричной рнк - Google Patents
Количественная оценка эффективности кэп матричной рнкInfo
- Publication number
- EA201591286A1 EA201591286A1 EA201591286A EA201591286A EA201591286A1 EA 201591286 A1 EA201591286 A1 EA 201591286A1 EA 201591286 A EA201591286 A EA 201591286A EA 201591286 A EA201591286 A EA 201591286A EA 201591286 A1 EA201591286 A1 EA 201591286A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- mrna
- efficiency
- cep
- capped
- quantitative estimation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6804—Nucleic acid analysis using immunogens
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Chemical Kinetics & Catalysis (AREA)
Abstract
Настоящее изобретение предоставляет, помимо прочего, способы количественной оценки эффективности кэпирования мРНК, в особенности мРНК, синтезированной in vitro. В некоторых вариантах осуществления способы согласно настоящему изобретению включают предоставление образца мРНК, содержащего кэпированную и некэпированную мРНК, предоставление кэп-специфического связывающего вещества в условиях, которые позволяют образовать комплекс между кэп-специфическим связывающим веществом и кэпированной мРНК, и количественное определение количества комплекса в сравнении с контролем с подсчетом эффективности кэпирования мРНК.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361784253P | 2013-03-14 | 2013-03-14 | |
PCT/US2014/027602 WO2014152673A1 (en) | 2013-03-14 | 2014-03-14 | Quantitative assessment for cap efficiency of messenger rna |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201591286A1 true EA201591286A1 (ru) | 2016-02-29 |
Family
ID=50625146
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201591286A EA201591286A1 (ru) | 2013-03-14 | 2014-03-14 | Количественная оценка эффективности кэп матричной рнк |
Country Status (13)
Country | Link |
---|---|
US (3) | US10626439B2 (ru) |
EP (2) | EP3495505A1 (ru) |
JP (1) | JP2016515216A (ru) |
CN (1) | CN105209633A (ru) |
AU (1) | AU2014239264A1 (ru) |
BR (1) | BR112015022141A2 (ru) |
CA (1) | CA2903488A1 (ru) |
DK (1) | DK2971098T3 (ru) |
EA (1) | EA201591286A1 (ru) |
ES (1) | ES2708562T3 (ru) |
MX (1) | MX2015011945A (ru) |
TR (1) | TR201901396T4 (ru) |
WO (1) | WO2014152673A1 (ru) |
Families Citing this family (67)
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WO2013185067A1 (en) | 2012-06-08 | 2013-12-12 | Shire Human Genetic Therapies, Inc. | Nuclease resistant polynucleotides and uses thereof |
AU2014239250A1 (en) | 2013-03-14 | 2015-08-27 | Shire Human Genetic Therapies, Inc. | Quantitative assessment for cap efficiency of messenger RNA |
EA037922B1 (ru) | 2013-03-14 | 2021-06-07 | Шир Хьюман Дженетик Терапис, Инк. | мРНК CFTR И КОМПОЗИЦИИ ДЛЯ ЛЕЧЕНИЯ МУКОВИСЦИДОЗА У МЛЕКОПИТАЮЩЕГО |
EP2970955B1 (en) | 2013-03-14 | 2018-11-14 | Translate Bio, Inc. | Methods for purification of messenger rna |
MX2015011945A (es) | 2013-03-14 | 2015-12-01 | Shire Human Genetic Therapies | Evaluacion cuantitativa para la eficacia de los casquetes de arn mensajero. |
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EA034103B1 (ru) | 2013-10-22 | 2019-12-27 | Транслейт Био, Инк. | СПОСОБ ЛЕЧЕНИЯ ФЕНИЛКЕТОНУРИИ С ПРИМЕНЕНИЕМ мРНК |
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-
2014
- 2014-03-14 MX MX2015011945A patent/MX2015011945A/es unknown
- 2014-03-14 ES ES14720376T patent/ES2708562T3/es active Active
- 2014-03-14 EP EP18207398.1A patent/EP3495505A1/en active Pending
- 2014-03-14 JP JP2016502491A patent/JP2016515216A/ja not_active Withdrawn
- 2014-03-14 BR BR112015022141A patent/BR112015022141A2/pt not_active IP Right Cessation
- 2014-03-14 CN CN201480010108.7A patent/CN105209633A/zh active Pending
- 2014-03-14 DK DK14720376.4T patent/DK2971098T3/en active
- 2014-03-14 EP EP14720376.4A patent/EP2971098B1/en active Active
- 2014-03-14 WO PCT/US2014/027602 patent/WO2014152673A1/en active Application Filing
- 2014-03-14 US US14/775,844 patent/US10626439B2/en active Active
- 2014-03-14 AU AU2014239264A patent/AU2014239264A1/en not_active Withdrawn
- 2014-03-14 CA CA2903488A patent/CA2903488A1/en not_active Abandoned
- 2014-03-14 TR TR2019/01396T patent/TR201901396T4/tr unknown
- 2014-03-14 EA EA201591286A patent/EA201591286A1/ru unknown
-
2020
- 2020-01-16 US US16/744,985 patent/US11104934B2/en active Active
-
2021
- 2021-05-19 US US17/325,092 patent/US11920182B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
BR112015022141A2 (pt) | 2017-08-29 |
EP3495505A1 (en) | 2019-06-12 |
WO2014152673A1 (en) | 2014-09-25 |
ES2708562T3 (es) | 2019-04-10 |
US11920182B2 (en) | 2024-03-05 |
CN105209633A (zh) | 2015-12-30 |
MX2015011945A (es) | 2015-12-01 |
US20160002705A1 (en) | 2016-01-07 |
US10626439B2 (en) | 2020-04-21 |
US20200318156A1 (en) | 2020-10-08 |
US11104934B2 (en) | 2021-08-31 |
US20210371900A1 (en) | 2021-12-02 |
DK2971098T3 (en) | 2019-02-18 |
CA2903488A1 (en) | 2014-09-25 |
EP2971098B1 (en) | 2018-11-21 |
AU2014239264A1 (en) | 2015-08-27 |
TR201901396T4 (tr) | 2019-02-21 |
JP2016515216A (ja) | 2016-05-26 |
EP2971098A1 (en) | 2016-01-20 |
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