DK2354148T3 - Nukleosidanaloger og oligonukleotiderivate omfattende nukleotidanalog deraf - Google Patents
Nukleosidanaloger og oligonukleotiderivate omfattende nukleotidanalog derafInfo
- Publication number
- DK2354148T3 DK2354148T3 DK10011213.5T DK10011213T DK2354148T3 DK 2354148 T3 DK2354148 T3 DK 2354148T3 DK 10011213 T DK10011213 T DK 10011213T DK 2354148 T3 DK2354148 T3 DK 2354148T3
- Authority
- DK
- Denmark
- Prior art keywords
- analogs
- oligonucleotide derivatives
- nucleoside
- nucleotide
- nucleotide analogs
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002035706 | 2002-02-13 | ||
EP03705109A EP1481983A4 (en) | 2002-02-13 | 2003-02-13 | NUCLEOSIDE ANALOGUE AND OLIGONUCLEOTIDE DERIVATIVES CONTAINING A NUCLEOTIDE ANALOGON THEREOF |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2354148T3 true DK2354148T3 (da) | 2013-10-14 |
Family
ID=27678064
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK10011213.5T DK2354148T3 (da) | 2002-02-13 | 2003-02-13 | Nukleosidanaloger og oligonukleotiderivate omfattende nukleotidanalog deraf |
Country Status (7)
Country | Link |
---|---|
US (1) | US7615619B2 (da) |
EP (2) | EP2354148B1 (da) |
JP (2) | JP4383176B2 (da) |
AU (1) | AU2003211953A1 (da) |
DK (1) | DK2354148T3 (da) |
ES (1) | ES2431586T3 (da) |
WO (1) | WO2003068795A1 (da) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7427672B2 (en) | 2003-08-28 | 2008-09-23 | Takeshi Imanishi | Artificial nucleic acids of n-o bond crosslinkage type |
WO2007026824A1 (ja) * | 2005-08-31 | 2007-03-08 | Osaka University | オリゴヌクレオチド類縁体 |
WO2010150789A1 (ja) | 2009-06-23 | 2010-12-29 | 武田薬品工業株式会社 | 核酸の合成法 |
AU2010312751B2 (en) | 2009-10-29 | 2014-07-24 | Osaka University | Bridged artificial nucleoside and nucleotide |
EP2551273A4 (en) | 2010-01-20 | 2013-10-16 | Univ Tokyo | PHOSPHORYLATION REAGENT |
ES2622716T3 (es) * | 2012-09-21 | 2017-07-07 | Osaka University | Oligonucleótido y nucleósido artificial en puente con guanidina |
WO2014051076A1 (ja) | 2012-09-28 | 2014-04-03 | 株式会社Bna | Bnaクランプ法 |
WO2014112463A1 (ja) * | 2013-01-15 | 2014-07-24 | 国立大学法人大阪大学 | スルホンアミド構造を有するヌクレオシドおよびヌクレオチド |
WO2014126229A1 (ja) | 2013-02-18 | 2014-08-21 | 塩野義製薬株式会社 | 含窒素複素環構造を有するヌクレオシド及びヌクレオチド |
EP3109254B1 (en) | 2014-02-18 | 2018-04-11 | Osaka University | Crosslinked nucleoside and nucleotide |
GB201410693D0 (en) | 2014-06-16 | 2014-07-30 | Univ Southampton | Splicing modulation |
CN107109411B (zh) | 2014-10-03 | 2022-07-01 | 冷泉港实验室 | 核基因输出的定向增加 |
TW201718618A (zh) | 2015-09-18 | 2017-06-01 | 田邊三菱製藥股份有限公司 | 架橋型核酸GuNA,其製造方法,及中間體化合物 |
AU2016334804B2 (en) | 2015-10-09 | 2022-03-31 | University Of Southampton | Modulation of gene expression and screening for deregulated protein expression |
CN109312343B (zh) | 2015-12-14 | 2022-09-27 | 冷泉港实验室 | 用于治疗常染色体显性精神发育迟滞5型和Dravet综合征的反义寡聚体 |
US11096956B2 (en) | 2015-12-14 | 2021-08-24 | Stoke Therapeutics, Inc. | Antisense oligomers and uses thereof |
CN116064544A (zh) | 2016-01-26 | 2023-05-05 | 日产化学株式会社 | 单链寡核苷酸 |
MX2019009305A (es) | 2017-02-06 | 2019-09-19 | Nissan Chemical Corp | Oligonucleotido de cadena simple. |
EP3603648A4 (en) | 2017-03-29 | 2020-12-30 | Shionogi & Co., Ltd | COMPLEX OF NUCLEIC ACID MEDICINAL AND MULTI-BRANCHED LIPID |
TW201920671A (zh) | 2017-07-26 | 2019-06-01 | 日商日產化學股份有限公司 | 單股寡核苷酸 |
SI3673080T1 (sl) | 2017-08-25 | 2024-03-29 | Stoke Therapeutics, Inc. | Protismiselni oligomeri za zdravljenje bolezenskih stanj in bolezni |
IL272864B2 (en) | 2017-08-31 | 2024-03-01 | Mitsubishi Tanabe Pharma Corp | A therapeutic agent containing an IL-33 antagonist for the treatment of endometriosis |
US12060558B2 (en) | 2018-05-04 | 2024-08-13 | Stoke Therapeutics, Inc. | Methods and compositions for treatment of cholesteryl ester storage disease |
JP7413362B2 (ja) | 2019-03-29 | 2024-01-15 | シスメックス株式会社 | 新規人工核酸、その製造方法及び用途 |
JPWO2021020412A1 (da) | 2019-07-30 | 2021-02-04 | ||
US20230348522A1 (en) * | 2019-10-18 | 2023-11-02 | Daiichi Sankyo Company, Limited | Method for producing bicyclic phosphoramidite |
IL298063A (en) | 2020-05-11 | 2023-01-01 | Stoke Therapeutics Inc | opa1 antisense oligomers for the treatment of conditions and diseases |
JPWO2022065413A1 (da) | 2020-09-25 | 2022-03-31 | ||
CN118369437A (zh) | 2021-12-10 | 2024-07-19 | 日东纺绩株式会社 | 用于检测核酸的对象碱基序列中的变异的方法、选择性地抑制核酸的扩增的方法、及用于实施这些的试剂盒 |
JP7421718B2 (ja) | 2021-12-10 | 2024-01-25 | 日東紡績株式会社 | 核酸の対象塩基配列中における変異を検出するための方法、核酸の増幅を選択的に阻害する方法、およびこれらを実施するためのキット |
CN118382707A (zh) | 2021-12-10 | 2024-07-23 | 日东纺绩株式会社 | 双链核酸的融解温度升高化剂及其用途 |
JPWO2023127857A1 (da) | 2021-12-27 | 2023-07-06 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3756313B2 (ja) | 1997-03-07 | 2006-03-15 | 武 今西 | 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体 |
US6770748B2 (en) * | 1997-03-07 | 2004-08-03 | Takeshi Imanishi | Bicyclonucleoside and oligonucleotide analogue |
US6794499B2 (en) * | 1997-09-12 | 2004-09-21 | Exiqon A/S | Oligonucleotide analogues |
CN1273478C (zh) * | 1999-02-12 | 2006-09-06 | 三共株式会社 | 新型核苷及低聚核苷酸类似物 |
JP4151751B2 (ja) * | 1999-07-22 | 2008-09-17 | 第一三共株式会社 | 新規ビシクロヌクレオシド類縁体 |
WO2002018388A1 (fr) * | 2000-08-29 | 2002-03-07 | Takeshi Imanishi | Analogues de nucleosides et derives d'oligonucleotides renfermant ces analogues |
-
2003
- 2003-02-13 EP EP10011213.5A patent/EP2354148B1/en not_active Expired - Lifetime
- 2003-02-13 JP JP2003567921A patent/JP4383176B2/ja not_active Expired - Fee Related
- 2003-02-13 AU AU2003211953A patent/AU2003211953A1/en not_active Abandoned
- 2003-02-13 EP EP03705109A patent/EP1481983A4/en not_active Withdrawn
- 2003-02-13 US US10/504,165 patent/US7615619B2/en not_active Expired - Fee Related
- 2003-02-13 WO PCT/JP2003/001485 patent/WO2003068795A1/ja active Application Filing
- 2003-02-13 DK DK10011213.5T patent/DK2354148T3/da active
- 2003-02-13 ES ES10011213T patent/ES2431586T3/es not_active Expired - Lifetime
-
2009
- 2009-06-19 JP JP2009147035A patent/JP5030998B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US7615619B2 (en) | 2009-11-10 |
US20060166908A1 (en) | 2006-07-27 |
EP2354148B1 (en) | 2013-09-04 |
EP1481983A4 (en) | 2008-04-02 |
EP2354148A3 (en) | 2011-10-19 |
JP4383176B2 (ja) | 2009-12-16 |
WO2003068795A1 (fr) | 2003-08-21 |
EP2354148A2 (en) | 2011-08-10 |
JP2009215314A (ja) | 2009-09-24 |
AU2003211953A1 (en) | 2003-09-04 |
EP1481983A1 (en) | 2004-12-01 |
JP5030998B2 (ja) | 2012-09-19 |
JPWO2003068795A1 (ja) | 2005-06-02 |
ES2431586T3 (es) | 2013-11-27 |
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