MX2020000387A - Método general y directo para preparar nanopartículas de estructura organometálica funcionalizadas con oligonucleotidos. - Google Patents

Método general y directo para preparar nanopartículas de estructura organometálica funcionalizadas con oligonucleotidos.

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Publication number
MX2020000387A
MX2020000387A MX2020000387A MX2020000387A MX2020000387A MX 2020000387 A MX2020000387 A MX 2020000387A MX 2020000387 A MX2020000387 A MX 2020000387A MX 2020000387 A MX2020000387 A MX 2020000387A MX 2020000387 A MX2020000387 A MX 2020000387A
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Mexico
Prior art keywords
organic framework
functiona
general
direct method
metal
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MX2020000387A
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English (en)
Inventor
Chad A Mirkin
Shunzhi Wang
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Univ Northwestern
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Publication of MX2020000387A publication Critical patent/MX2020000387A/es

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    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/003—Compounds containing elements of Groups 4 or 14 of the Periodic System without C-Metal linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6923—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
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    • C07F15/02—Iron compounds
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    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific

Abstract

La presente divulgación generalmente se refiere a nanopartículas de estructura organometálica que contienen oligonucleótidos modificados con fosfato terminal, métodos para elaborarlas y métodos para usarlas.
MX2020000387A 2017-07-13 2018-07-13 Método general y directo para preparar nanopartículas de estructura organometálica funcionalizadas con oligonucleotidos. MX2020000387A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762532241P 2017-07-13 2017-07-13
PCT/US2018/042050 WO2019032241A1 (en) 2017-07-13 2018-07-13 GENERAL AND DIRECT METHOD FOR PREPARING NANOPARTICLES WITH ORGANOMETALLIC STRUCTURE FUNCTIONALIZED BY OLIGONUCLEOTIDES

Publications (1)

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MX2020000387A true MX2020000387A (es) 2020-08-17

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Country Link
US (1) US11690920B2 (es)
EP (1) EP3652186A4 (es)
JP (1) JP2020526558A (es)
KR (1) KR20200028997A (es)
AU (1) AU2018314159A1 (es)
CA (1) CA3069909A1 (es)
MX (1) MX2020000387A (es)
WO (1) WO2019032241A1 (es)

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JP7180522B2 (ja) * 2019-04-22 2022-11-30 トヨタ自動車株式会社 有機金属構造体
CN110025596A (zh) * 2019-04-25 2019-07-19 上海理工大学 一种纳米复合颗粒及其制备方法
CN110437458B (zh) * 2019-07-25 2021-04-02 北京化工大学 一种能重复使用的类芬顿催化剂[NH2-MIL-101(Fe)]的制备及应用方法
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JPWO2021054407A1 (es) * 2019-09-18 2021-03-25
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CN111303443B (zh) * 2020-03-03 2021-09-28 山西大学 一种锌配位聚合物及其制备方法和应用
CN111876147B (zh) * 2020-08-03 2023-04-21 青岛大学 银纳米粒/硫量子点双掺杂mof复合物比率荧光外泌体适体探针的制备方法
CN112707966A (zh) * 2020-12-18 2021-04-27 华南理工大学 一种蛋白质与多级孔道金属有机骨架复合物及其制备方法与应用
CN113308516B (zh) * 2021-04-29 2022-10-11 重庆医科大学 基于DNA树枝结构@Zr-MOF检测HBV-DNA的SPRi传感器的制备与应用
CN114437709B (zh) * 2021-09-15 2023-07-14 中国科学院海洋研究所 一种核酸功能化mof材料及其制备和应用
CN113801336B (zh) * 2021-09-26 2022-06-24 中山大学 一种金属有机骨架材料UiO-67-4Me的功能化及其功能化产物和应用
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WO2023076833A1 (en) * 2021-10-26 2023-05-04 Singular Genomics Systems, Inc. Multiplexed targeted amplification of polynucleotides
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