RU2009126723A - Антитела к ox40l - Google Patents
Антитела к ox40l Download PDFInfo
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Abstract
1. Антитело, которое связывается с OX40L человека, отличающееся тем, что содержит Fc-фрагмент, полученный из организма человека, и не связывается с фактором комплемента Clq, а также включает комбинацию вариабельных областей, независимо друг от друга выбранных из группы, включающий следующие комбинации: ! а) вариабельная область легкой цепи, которая имеет аминокислотную последовательность SEQ ID NO: 1, и вариабельная область тяжелой цепи, которая имеет последовательность SEQ ID NO: 2; ! б) вариабельная область легкой цепи, которая имеет аминокислотную последовательность SEQ ID NO: 3, и вариабельная область тяжелой цепи, которая имеет последовательность SEQ ID NO: 4; ! в) вариабельная область легкой цепи, которая имеет аминокислотную последовательность SEQ ID NO: 5, и вариабельная область тяжелой цепи, которая имеет последовательность SEQ ID NO: 6; ! г) вариабельная область легкой цепи, которая имеет аминокислотную последовательность SEQ ID NO: 7, и вариабельная область тяжелой цепи, которая имеет последовательность SEQ ID NO: 8; ! д) вариабельная область легкой цепи, которая имеет аминокислотную последовательность SEQ ID NO: 9, и вариабельная область тяжелой цепи, которая имеет последовательность SEQ ID NO: 10; ! е) вариабельная область легкой цепи, которая имеет аминокислотную последовательность SEQ ID NO: 11 или 16, и вариабельная область тяжелой цепи, которая имеет последовательность SEQ ID NO: 12. ! 2. Антитело, которое связывается с OX40L человека, отличающееся тем, что содержит Fc-фрагмент, полученный из организма человека, и не связывается с фактором комплемента Clq, и включает в качестве ! а) тяжелой γ-цепи SEQ ID NO: 58 и легкой каппа-цепи SEQ ID NO: 61, ! б) тяжелой γ-цепи SEQ ID NO: 62 и легкой �
Claims (22)
1. Антитело, которое связывается с OX40L человека, отличающееся тем, что содержит Fc-фрагмент, полученный из организма человека, и не связывается с фактором комплемента Clq, а также включает комбинацию вариабельных областей, независимо друг от друга выбранных из группы, включающий следующие комбинации:
а) вариабельная область легкой цепи, которая имеет аминокислотную последовательность SEQ ID NO: 1, и вариабельная область тяжелой цепи, которая имеет последовательность SEQ ID NO: 2;
б) вариабельная область легкой цепи, которая имеет аминокислотную последовательность SEQ ID NO: 3, и вариабельная область тяжелой цепи, которая имеет последовательность SEQ ID NO: 4;
в) вариабельная область легкой цепи, которая имеет аминокислотную последовательность SEQ ID NO: 5, и вариабельная область тяжелой цепи, которая имеет последовательность SEQ ID NO: 6;
г) вариабельная область легкой цепи, которая имеет аминокислотную последовательность SEQ ID NO: 7, и вариабельная область тяжелой цепи, которая имеет последовательность SEQ ID NO: 8;
д) вариабельная область легкой цепи, которая имеет аминокислотную последовательность SEQ ID NO: 9, и вариабельная область тяжелой цепи, которая имеет последовательность SEQ ID NO: 10;
е) вариабельная область легкой цепи, которая имеет аминокислотную последовательность SEQ ID NO: 11 или 16, и вариабельная область тяжелой цепи, которая имеет последовательность SEQ ID NO: 12.
2. Антитело, которое связывается с OX40L человека, отличающееся тем, что содержит Fc-фрагмент, полученный из организма человека, и не связывается с фактором комплемента Clq, и включает в качестве
а) тяжелой γ-цепи SEQ ID NO: 58 и легкой каппа-цепи SEQ ID NO: 61,
б) тяжелой γ-цепи SEQ ID NO: 62 и легкой каппа-цепи SEQ ID NO: 65 или
в) тяжелой γ-цепи SEQ ID NO: 66 и легкой каппа-цепи SEQ ID NO: 69.
3. Антитело по п.1, отличающееся тем, что антитело представляет собой Fab-, F(ab')2- или одноцепочечный фрагмент.
4. Антитело по п.2, отличающееся тем, что антитело представляет собой Fab-, F(ab')2- или одноцепочечный фрагмент.
5. Молекула нуклеиновой кислоты, кодирующая молекулу антитела, отличающаяся тем, что указанное антитело связывается с OX40L человека и содержит комбинацию вариабельных областей, независимо друг от друга выбранных из группы, включающий следующие комбинации:
а) вариабельная область легкой цепи, которая имеет аминокислотную последовательность SEQ ID NO: 1, и вариабельная область тяжелой цепи, которая имеет последовательность SEQ ID NO: 2;
б) вариабельная область легкой цепи, которая имеет аминокислотную последовательность SEQ ID NO: 3, и вариабельная область тяжелой цепи, которая имеет последовательность SEQ ID NO: 4;
в) вариабельная область легкой цепи, которая имеет аминокислотную последовательность SEQ ID NO: 5, и вариабельная область тяжелой цепи, которая имеет последовательность SEQ ID NO: 6;
г) вариабельная область легкой цепи, которая имеет аминокислотную последовательность SEQ ID NO: 7, и вариабельная область тяжелой цепи, которая имеет последовательность SEQ ID NO: 8;
д) вариабельная область легкой цепи, которая имеет аминокислотную последовательность SEQ ID NO: 9, и вариабельная область тяжелой цепи, которая имеет последовательность SEQ ID NO: 10;
е) вариабельная область легкой цепи, которая имеет аминокислотную последовательность SEQ ID NO: 11 или 16, и вариабельная область тяжелой цепи, которая имеет последовательность SEQ ID NO: 12.
6. Молекула нуклеиновой кислоты, кодирующая антитело, которое связывается с OX40L человека, отличающаяся тем, что она кодирует антитело, включающее
а) тяжелой γ-цепи SEQ ID NO: 58 и легкой каппа-цепи SEQ ID NO: 61,
б) тяжелой γ-цепи SEQ ID NO: 62 и легкой каппа-цепи SEQ ID NO: 65 или
в) тяжелой γ-цепи SEQ ID NO: 66 и легкой каппа-цепи SEQ ID NO: 69.
7. Вектор, содержащий молекулу нуклеиновой кислоты по п.5.
8. Вектор, содержащий молекулу нуклеиновой кислоты по п.6.
9. Клетка-хозяин, включающая вектор, который содержит молекулу нуклеиновой кислоты по п.5.
10. Клетка-хозяин, включающая вектор, который содержит молекулу нуклеиновой кислоты по п.6.
11. Способ получения антитела, которое связывается с OX40L человека и содержит Fc-фрагмент, полученный из организма человека, отличающийся тем, что культивируют клетку-хозяина, включающую вектор, содержащий молекулу нуклеиновой кислоты по п.5, в условиях, которые обеспечивают синтез молекулы антитела, и выделяют молекулу антитела из культуры.
12. Способ получения антитела, которое связывается с OX40L человека и содержит Fc-фрагмент, полученный из организма человека, отличающийся тем, что культивируют клетку-хозяина, включающую вектор, содержащий молекулу нуклеиновой кислоты по п.6, в условиях, которые обеспечивают синтез молекулы антитела, и выделяют молекулу антитела из культуры.
13. Способ получения антитела, которое связывается с OX40L человека, отличающийся тем, что последовательность нуклеиновой кислоты по п.5 модифицируют таким образом, чтобы это модифицированное антитело не связывалось с фактором комплемента Clq и/или человеческим Fcγ-рецептором на NK-клетках, встраивают указанную модифицированную первую нуклеиновую кислоту и вторую нуклеиновую кислоту, кодирующую легкую цепь антитела, в экспрессионный вектор, встраивают вектор в прокариотическую или эукариотическую клетку-хозяина, культивируют клетку-хозяина в условиях, которые обеспечивают синтез антитела, и выделяют антитело из культуры.
14. Способ получения антитела, которое связывается с OX40L человека, отличающийся тем, что последовательность нуклеиновой кислоты по п.6 модифицируют таким образом, чтобы это модифицированное антитело не связывалось с фактором комплемента Clq и/или человеческим Fcγ-рецептором на NK-клетках, встраивают указанную модифицированную первую нуклеиновую кислоту и вторую нуклеиновую кислоту, кодирующую легкую цепь антитела, в экспрессионный вектор, встраивают вектор в прокариотическую или эукариотическую клетку-хозяина, культивируют клетку-хозяина в условиях, которые обеспечивают синтез антитела, и выделяют антитело из культуры.
15. Композиция, содержащая молекулу антитела по п.1 в дозовом количестве 0,1 мг/кг.
16. Композиция, содержащая молекулу антитела по п.2 в дозовом количестве 0,1 мг/кг.
17. Композиция, содержащая молекулу антитела по п.1 в дозовом количестве 0,1 мг/кг и представляющая собой фармацевтическую или диагностическую композицию.
18. Композиция, содержащая молекулу антитела по п.2 в дозовом количестве 0,1 мг/кг и представляющая собой фармацевтическую или диагностическую композицию.
19. Фармацевтическая композиция, содержащая антитело по п.1 в дозовом количестве 0,1 мг/кг, и по меньшей мере один фармацевтически приемлемый эксципиент.
20. Фармацевтическая композиция, содержащая антитело по п.2 в дозовом количестве 0,1 мг/кг, и по меньшей мере один фармацевтически приемлемый эксципиент.
21. Применение антитела по п.1 для приготовления лекарственного средства, предназначенного для профилактики и лечения воспалительных заболеваний.
22. Применение антитела по п.2 для приготовления лекарственного средства, предназначенного для профилактики и лечения воспалительных заболеваний.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04022158.2 | 2004-09-17 | ||
| EP04022158 | 2004-09-17 | ||
| EP04030546.8 | 2004-12-23 | ||
| EP04030546 | 2004-12-23 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2007114328/13A Division RU2395523C2 (ru) | 2004-09-17 | 2005-09-16 | Антитела к ох40l |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2009126723A true RU2009126723A (ru) | 2011-01-20 |
| RU2423383C2 RU2423383C2 (ru) | 2011-07-10 |
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ID=35462606
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2009126723/10A RU2423383C2 (ru) | 2004-09-17 | 2005-09-16 | Антитела к ox40l |
| RU2007114328/13A RU2395523C2 (ru) | 2004-09-17 | 2005-09-16 | Антитела к ох40l |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2007114328/13A RU2395523C2 (ru) | 2004-09-17 | 2005-09-16 | Антитела к ох40l |
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| Country | Link |
|---|---|
| US (3) | US7501496B1 (ru) |
| EP (2) | EP1791869B1 (ru) |
| JP (2) | JP4594986B2 (ru) |
| KR (2) | KR100901090B1 (ru) |
| CN (1) | CN101684157A (ru) |
| AR (1) | AR051925A1 (ru) |
| AU (1) | AU2005284310B2 (ru) |
| BR (1) | BRPI0515554A (ru) |
| CA (1) | CA2580140C (ru) |
| CL (1) | CL2010000426A1 (ru) |
| ES (1) | ES2433916T3 (ru) |
| HK (1) | HK1108000A1 (ru) |
| IL (1) | IL181575A (ru) |
| MX (1) | MX2007002905A (ru) |
| MY (1) | MY149442A (ru) |
| NO (1) | NO20071430L (ru) |
| NZ (2) | NZ553333A (ru) |
| RU (2) | RU2423383C2 (ru) |
| SG (1) | SG147444A1 (ru) |
| TW (2) | TWI380996B (ru) |
| WO (1) | WO2006029879A2 (ru) |
Families Citing this family (864)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7291331B1 (en) | 2002-09-11 | 2007-11-06 | La Jolla Institute For Allergy And Immunology | Methods of treating OX40 medicated recall immune responses |
| JP5620626B2 (ja) | 2005-03-31 | 2014-11-05 | 中外製薬株式会社 | 会合制御によるポリペプチド製造方法 |
| BRPI0613361A2 (pt) | 2005-07-01 | 2011-01-04 | Medarex Inc | anticorpo monoclonal humano isolado, composição, imunoconjugado, molécula biespecìfica, molécula de ácido nucleico isolada, vetor de expressão, célula hospedeira, camundongo transgênico, método para modular uma resposta imune num indivìduo, método para inibir crescimento de células tumorais num indivìduo, método para tratar uma doença infecciosa num indivìduo, método para aumentar uma resposta imune a um antìgeno num indivìduo, método para tratar ou prevenir uma doença inflamatória num indivìduo e método para preparar o anticorpo anti-pd-l1 |
| AR057253A1 (es) * | 2005-12-16 | 2007-11-21 | Genentech Inc | Anticuerpos anti-ox40l y metodos que los utilizan |
| US9670269B2 (en) | 2006-03-31 | 2017-06-06 | Chugai Seiyaku Kabushiki Kaisha | Methods of modifying antibodies for purification of bispecific antibodies |
| EP4001409A1 (en) | 2006-03-31 | 2022-05-25 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
| WO2008011348A2 (en) | 2006-07-14 | 2008-01-24 | Ac Immune S.A. | Humanized antibody against amyloid beta |
| ES2902063T3 (es) | 2006-09-08 | 2022-03-24 | Abbvie Bahamas Ltd | Proteínas de unión a interleucina-13 |
| JP2010528583A (ja) * | 2007-06-11 | 2010-08-26 | エーシー イミューン ソシエテ アノニム | アミロイドβに対するヒト化抗体 |
| US8613923B2 (en) | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
| US8048420B2 (en) | 2007-06-12 | 2011-11-01 | Ac Immune S.A. | Monoclonal antibody |
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