BR112019001615A2 - métodos e composições para tratar mielofibrose - Google Patents

métodos e composições para tratar mielofibrose

Info

Publication number
BR112019001615A2
BR112019001615A2 BR112019001615-5A BR112019001615A BR112019001615A2 BR 112019001615 A2 BR112019001615 A2 BR 112019001615A2 BR 112019001615 A BR112019001615 A BR 112019001615A BR 112019001615 A2 BR112019001615 A2 BR 112019001615A2
Authority
BR
Brazil
Prior art keywords
methods
myelofibrosis
compositions
anemia
progression
Prior art date
Application number
BR112019001615-5A
Other languages
English (en)
Inventor
Kumar Ravindra
Venkata Sai Rajasekhar Suragani Naga
Original Assignee
Acceleron Pharma Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acceleron Pharma Inc. filed Critical Acceleron Pharma Inc.
Publication of BR112019001615A2 publication Critical patent/BR112019001615A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1796—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Abstract

em parte, a presente divulgação refere-se a métodos para tratar, prevenir ou reduzir a taxa de progressão e/ou severidade de mielofibrose ou uma ou mais complicações de mielofibrose (hematopoese extramedular, esplenomegalia, anemia e fibrose). em certos aspectos, a divulgação fornece antagonistas de actriib para o uso no tratamento, prevenção ou redução da taxa de progressão e/ou severidade de uma ou mais complicações associadas à terapia com inibidor de janus cinase em um paciente (por exemplo, anemia).
BR112019001615-5A 2016-07-27 2017-07-26 métodos e composições para tratar mielofibrose BR112019001615A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662367289P 2016-07-27 2016-07-27
US62/367,289 2016-07-27
PCT/US2017/043967 WO2018022762A1 (en) 2016-07-27 2017-07-26 Methods and compositions for treating myelofibrosis

Publications (1)

Publication Number Publication Date
BR112019001615A2 true BR112019001615A2 (pt) 2019-04-30

Family

ID=61017458

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019001615-5A BR112019001615A2 (pt) 2016-07-27 2017-07-26 métodos e composições para tratar mielofibrose

Country Status (12)

Country Link
US (2) US20180050085A1 (pt)
EP (1) EP3490582A4 (pt)
JP (2) JP7264580B2 (pt)
KR (1) KR20190040972A (pt)
CN (1) CN109789184A (pt)
AU (1) AU2017302282A1 (pt)
BR (1) BR112019001615A2 (pt)
CA (1) CA3031909A1 (pt)
EA (1) EA201990226A1 (pt)
MA (1) MA45811A (pt)
MX (1) MX2019001043A (pt)
WO (1) WO2018022762A1 (pt)

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Also Published As

Publication number Publication date
MA45811A (fr) 2019-06-05
WO2018022762A1 (en) 2018-02-01
JP2023014373A (ja) 2023-01-26
US20210322514A1 (en) 2021-10-21
EP3490582A1 (en) 2019-06-05
KR20190040972A (ko) 2019-04-19
MX2019001043A (es) 2019-09-26
EA201990226A1 (ru) 2019-08-30
JP7264580B2 (ja) 2023-04-25
AU2017302282A1 (en) 2019-02-07
US20180050085A1 (en) 2018-02-22
EP3490582A4 (en) 2020-04-01
JP2019522022A (ja) 2019-08-08
CN109789184A (zh) 2019-05-21
CA3031909A1 (en) 2018-02-01

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