ATE352638T1 - REVERSE ßTWO-HYBRIDß-SYSTEME - Google Patents
REVERSE ßTWO-HYBRIDß-SYSTEMEInfo
- Publication number
- ATE352638T1 ATE352638T1 AT96912683T AT96912683T ATE352638T1 AT E352638 T1 ATE352638 T1 AT E352638T1 AT 96912683 T AT96912683 T AT 96912683T AT 96912683 T AT96912683 T AT 96912683T AT E352638 T1 ATE352638 T1 AT E352638T1
- Authority
- AT
- Austria
- Prior art keywords
- protein
- methods
- rna
- reverse
- hybrid systems
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1055—Protein x Protein interaction, e.g. two hybrid selection
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/505—Cells of the immune system involving T-cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/37—Assays involving biological materials from specific organisms or of a specific nature from fungi
- G01N2333/39—Assays involving biological materials from specific organisms or of a specific nature from fungi from yeasts
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Toxicology (AREA)
- Organic Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Control Of Direct Current Motors (AREA)
- Bridges Or Land Bridges (AREA)
- Dram (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Paper (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42052595A | 1995-04-11 | 1995-04-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE352638T1 true ATE352638T1 (de) | 2007-02-15 |
Family
ID=23666820
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT96912683T ATE352638T1 (de) | 1995-04-11 | 1996-04-11 | REVERSE ßTWO-HYBRIDß-SYSTEME |
Country Status (9)
Country | Link |
---|---|
US (7) | US5955280A (de) |
EP (1) | EP0830459B1 (de) |
JP (2) | JPH11502717A (de) |
AT (1) | ATE352638T1 (de) |
AU (1) | AU716893B2 (de) |
CA (1) | CA2217545A1 (de) |
DE (1) | DE69636866D1 (de) |
NZ (2) | NZ502795A (de) |
WO (1) | WO1996032503A1 (de) |
Families Citing this family (110)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE352638T1 (de) * | 1995-04-11 | 2007-02-15 | Gen Hospital Corp | REVERSE ßTWO-HYBRIDß-SYSTEME |
US5830751A (en) * | 1996-05-01 | 1998-11-03 | The Johns Hopkins University | Genetic assays and strains using human TP53 |
US6083693A (en) | 1996-06-14 | 2000-07-04 | Curagen Corporation | Identification and comparison of protein-protein interactions that occur in populations |
US6897017B1 (en) * | 1997-01-31 | 2005-05-24 | Odyssey Thera Inc. | Vivo library-versus-library selection of optimized protein-protein interactions |
CA2205888A1 (en) | 1997-07-11 | 1999-01-11 | John J. Priatel | Complementation trap |
US5885779A (en) * | 1997-09-09 | 1999-03-23 | University Of British Columbia | Repressed trans-activator system for characterization of protein-protein interactions |
PL340433A1 (en) | 1997-11-10 | 2001-02-12 | Gen Hospital Corp | Detection systems for detecting and recording protein-specific actions and functional interactions |
US6905818B1 (en) | 1997-11-27 | 2005-06-14 | Max-Planck-Gesellschaft Zur Forderungder Wissenschaften | Method for the identification and characterization of interacting molecules by automated interaction mating |
GB2338711B (en) * | 1997-11-27 | 2000-11-15 | Max Planck Gesellschaft | Identification and characterization of interacting molecules |
CA2317816C (en) * | 1998-01-09 | 2009-02-17 | Tvw Telethon Institute For Child Health Research | Peptide detection method |
WO2000018964A1 (en) * | 1998-09-30 | 2000-04-06 | Boston Medical Center Corporation | Identification of virulence determinant activators in prokaryotic pathogens |
US6063578A (en) * | 1998-10-22 | 2000-05-16 | Signal Pharmaceuticals, Inc. | Dual reporter system and methods of use therefor |
US6203986B1 (en) * | 1998-10-22 | 2001-03-20 | Robert H. Singer | Visualization of RNA in living cells |
EP1792989A1 (de) | 1999-04-12 | 2007-06-06 | Agensys, Inc. | 13-Transmembrane Protein welches in Prostatakrebs exprimiert wird |
EP1171595A1 (de) | 1999-04-12 | 2002-01-16 | Agensys, Inc. | 13-transmembrane protein welches in prostatakrebs exprimiert wird |
CA2371596A1 (en) | 1999-04-30 | 2000-11-09 | Hybrigenics S.A. | Collection of prokaryotic dna for two hybrid systems helicobacter pylori protein-protein interactions and application thereof |
PT1992695E (pt) | 1999-08-12 | 2011-01-12 | Agensys Inc | Antigénio transmembranar lectina tipo c expresso em cancro da próstata humano e utilizações do mesmo |
IL147952A0 (en) | 1999-10-05 | 2002-08-14 | Agensys Inc | G protein-coupled receptor up-regulated in prostate cancer and uses thereof |
US6790607B1 (en) | 1999-10-07 | 2004-09-14 | Hybrigen, Inc. | Adjustable sensitivity, genetic molecular interaction systems, including protein-protein interaction systems for detection and analysis |
US6893818B1 (en) | 1999-10-28 | 2005-05-17 | Agensys, Inc. | Gene upregulated in cancers of the prostate |
DE19957065B4 (de) * | 1999-11-26 | 2005-01-05 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Screening-Verfahren für Arzneistoffe |
AU2001245584B2 (en) * | 2000-03-08 | 2007-02-08 | Phylogica Limited | Improved reverse n-hybrid screening method |
WO2001066787A1 (en) * | 2000-03-08 | 2001-09-13 | Tvw Telethon Institute For Child Health Research | Improved reverse n-hybrid screening method |
US20030211495A1 (en) * | 2000-03-08 | 2003-11-13 | Richard Hopkins | Reverse n-hybrid screening method |
US7029847B2 (en) | 2000-05-16 | 2006-04-18 | Massachusetts Institute Of Technology | Methods and compositions for interaction trap assays |
WO2001088197A2 (en) * | 2000-05-16 | 2001-11-22 | Massachusetts Institute Of Technology | Methods and compositions for interaction trap assays |
US6902882B2 (en) | 2000-05-23 | 2005-06-07 | Kerong Gu | Methods of monitoring production of gene products and uses thereof |
US6406863B1 (en) * | 2000-06-23 | 2002-06-18 | Genetastix Corporation | High throughput generation and screening of fully human antibody repertoire in yeast |
DK1299727T3 (da) | 2000-07-12 | 2009-06-15 | Agensys Inc | Hidtil ukendt tumorantigen, der er egnet til diagnosticering og behandling af blære-, ovarie-, lunge-, og nyrecancertyper |
US7198924B2 (en) | 2000-12-11 | 2007-04-03 | Invitrogen Corporation | Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites |
DE60135232D1 (de) | 2000-08-28 | 2008-09-18 | Agensys Inc | Nukleinsäure und korrespondierendes protein 85p1b3, nützlich zur behandlung und detektion von krebserkrankungen |
US6787321B1 (en) | 2000-10-13 | 2004-09-07 | The Regents Of The University Of California | Mammalian two-hybrid system for screening for modulators of the accumulation of metabolic products |
AU2002225623A8 (en) * | 2000-11-17 | 2009-07-30 | John G Wise | Creation and identification of proteins having new dna binding specificities |
WO2002070662A2 (en) | 2001-03-02 | 2002-09-12 | Gpc Biotech Ag | Three hybrid assay system |
EP1370678A4 (de) * | 2001-03-02 | 2005-09-07 | Mds Proteomics Inc | Verfahren und reagenzien zur apoptoseregulation |
US6924358B2 (en) | 2001-03-05 | 2005-08-02 | Agensys, Inc. | 121P1F1: a tissue specific protein highly expressed in various cancers |
US7271240B2 (en) | 2001-03-14 | 2007-09-18 | Agensys, Inc. | 125P5C8: a tissue specific protein highly expressed in various cancers |
US20030191073A1 (en) | 2001-11-07 | 2003-10-09 | Challita-Eid Pia M. | Nucleic acid and corresponding protein entitled 161P2F10B useful in treatment and detection of cancer |
EP2280030A3 (de) | 2001-04-10 | 2011-06-15 | Agensys, Inc. | Nukleinsäuren und zugehörige Proteine für die Behandlung und den Nachweis von Krebs |
US6841352B2 (en) | 2001-06-29 | 2005-01-11 | Myriad Genetics, Inc. | Mating-based method for detecting protein—protein interaction |
CA2652991A1 (en) * | 2001-07-16 | 2003-11-13 | Caprotec Bioanalytics Gmbh | Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions |
US6833441B2 (en) | 2001-08-01 | 2004-12-21 | Abmaxis, Inc. | Compositions and methods for generating chimeric heteromultimers |
WO2003018749A2 (en) * | 2001-08-22 | 2003-03-06 | Shengfeng Li | Compositions and methods for generating antigen-binding units |
JP2005505271A (ja) | 2001-09-06 | 2005-02-24 | アジェンシス, インコーポレイテッド | 癌の処置および検出において有用なsteap−1と名称が与えられる核酸および対応するタンパク質 |
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US20030129634A1 (en) * | 2001-11-07 | 2003-07-10 | Evans David R.H. | General screening method for ligand-protein interactions |
US20040161753A1 (en) * | 2001-11-16 | 2004-08-19 | Wise John G. | Creation and identification of proteins having new dna binding specificities |
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US20040067532A1 (en) | 2002-08-12 | 2004-04-08 | Genetastix Corporation | High throughput generation and affinity maturation of humanized antibody |
AU2003243151A1 (en) | 2002-08-16 | 2004-03-03 | Agensys, Inc. | Nucleic acid and corresponding protein entitled 251p5g2 useful in treatment and detection of cancer |
CA2658334C (en) * | 2003-01-16 | 2012-07-10 | Caprotec Bioanalytics Gmbh | Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions |
EP2343315A3 (de) | 2003-02-10 | 2011-11-23 | Agensys, Inc. | Nukleinsäure und entsprechendes Protein mit der Bezeichnung 158P1D7, das sich für die Behandlung und den Nachweis von Blasenkrebs und anderen Krebserkrankungen eignet |
CA2525250A1 (en) * | 2003-05-09 | 2004-11-25 | Health Research Inc. | Improved methods for protein interaction determination |
PT1629088E (pt) | 2003-05-30 | 2012-04-10 | Agensys Inc | Variantes de antigénio de células estaminais de próstata (psca) e subsequências das mesmas |
US20060286600A1 (en) * | 2003-06-30 | 2006-12-21 | Albertha Walhout | High throughput one-hybrid system |
ATE469984T1 (de) | 2003-12-01 | 2010-06-15 | Life Technologies Corp | Rekombinationsstellen enthaltende nukleinsäuremoleküle und verfahren zur verwendung davon |
EP1729793B1 (de) | 2004-03-02 | 2015-07-22 | Acceleron Pharma Inc. | Alk7 und myostatin-hemmer zur behandlung von muskelschwund |
JP4651663B2 (ja) | 2004-05-28 | 2011-03-16 | アジェンシス,インコーポレイテッド | Pscaタンパク質に結合する抗体および関連分子 |
US8034553B2 (en) | 2004-06-24 | 2011-10-11 | Kimberly-Clark Worldwide, Inc. | Biomarkers for wound healing |
JP2008507288A (ja) | 2004-07-23 | 2008-03-13 | アクセルロン ファーマ インコーポレーテッド | ActRII受容体ポリペプチド、方法、および組成物 |
FR2877010B1 (fr) * | 2004-10-25 | 2007-03-16 | Aventis Pharma Sa | Systeme double-hybride base sur la mise sous silence de genes par interference transcriptionnelle |
WO2006105488A2 (en) | 2005-03-31 | 2006-10-05 | Agensys, Inc. | Antibodies and related molecules that bind to 161p2f10b proteins |
KR20160137665A (ko) | 2005-11-23 | 2016-11-30 | 악셀레론 파마 인코포레이티드 | 액티빈-actrⅱa 길항제 및 골 성장을 촉진하기 위한 이들의 용도 |
NZ707292A (en) | 2006-12-18 | 2017-06-30 | Acceleron Pharma Inc | Activin-actrii antagonists and uses for increasing red blood cell levels |
MX354099B (es) | 2007-02-01 | 2018-02-13 | Acceleron Pharma Inc | Antagonistas de activina-actriia y usos para tratar o prevenir cancer de mama. |
TWI782836B (zh) | 2007-02-02 | 2022-11-01 | 美商艾瑟勒朗法瑪公司 | 衍生自ActRIIB的變體與其用途 |
DK2120999T3 (da) | 2007-02-09 | 2012-12-03 | Acceleron Pharma Inc | Farmaceutiske sammensætninger omfattende Activin-ActRIIA antagonister samt anvendelse deraf ved forebyggelse eller behandling af multipelt myelom |
US7932030B2 (en) * | 2007-04-05 | 2011-04-26 | The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | System for pulling out regulatory elements using yeast |
US8877688B2 (en) | 2007-09-14 | 2014-11-04 | Adimab, Llc | Rationally designed, synthetic antibody libraries and uses therefor |
AU2008298603B2 (en) | 2007-09-14 | 2015-04-30 | Adimab, Llc | Rationally designed, synthetic antibody libraries and uses therefor |
EP3243524A1 (de) | 2007-09-18 | 2017-11-15 | Acceleron Pharma Inc. | Activin-actriia antagonisten und verfahren zur verringerung oder inhibierung der fsh-sekretion |
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TW201919685A (zh) | 2008-08-14 | 2019-06-01 | 美商艾瑟勒朗法瑪公司 | 使用gdf阱以增加紅血球水平 |
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EP3058986B1 (de) | 2009-03-30 | 2018-05-09 | Acceleron Pharma Inc. | Bmp-alk3-antagonisten und ihre verwendung zur förderung des knochenwachstums |
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MX2012001916A (es) | 2009-08-13 | 2012-05-22 | Acceleron Pharma Inc | Uso combinado de trampas gdf y activadores de receptor de eritropoyetina para incrementar los niveles de globulos rojos. |
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JP6267425B2 (ja) | 2009-11-17 | 2018-01-24 | アクセルロン ファーマ, インコーポレイテッド | 筋ジストロフィー治療のためのユートロフィン誘導に関するactriibタンパク質およびその改変体およびその使用 |
EP2553097A1 (de) | 2010-03-26 | 2013-02-06 | Integratech Proteomics, LLC | Hybridsysteme mit gesteuerter freigabe |
EP3336225B1 (de) | 2010-07-16 | 2020-02-19 | Adimab, LLC | Antikörperbibliotheken |
WO2013036829A1 (en) | 2011-09-09 | 2013-03-14 | Genentech, Inc | Treatment of th17 mediated inflammatory diseases |
WO2013059347A1 (en) | 2011-10-17 | 2013-04-25 | Acceleron Pharma, Inc. | Methods and compositions for treating ineffective erythropoiesis |
US8903454B2 (en) * | 2011-11-07 | 2014-12-02 | Alcatel Lucent | Base station and radio unit for creating overlaid sectors with carrier aggregation |
KR20220156979A (ko) | 2012-11-02 | 2022-11-28 | 셀진 코포레이션 | 골 및 다른 장애를 치료하기 위한 액티빈-actrii 길항제 및 용도 |
WO2015027082A1 (en) | 2013-08-22 | 2015-02-26 | Acceleron Pharma, Inc. | Tgf-beta receptor type ii variants and uses thereof |
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CN107135646B (zh) | 2014-06-13 | 2022-03-15 | 阿塞勒隆制药公司 | 用于治疗溃疡的方法和组合物 |
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1996
- 1996-04-11 AT AT96912683T patent/ATE352638T1/de not_active IP Right Cessation
- 1996-04-11 WO PCT/US1996/004995 patent/WO1996032503A1/en active IP Right Grant
- 1996-04-11 DE DE69636866T patent/DE69636866D1/de not_active Expired - Lifetime
- 1996-04-11 EP EP96912683A patent/EP0830459B1/de not_active Expired - Lifetime
- 1996-04-11 NZ NZ502795A patent/NZ502795A/en not_active IP Right Cessation
- 1996-04-11 NZ NZ306767A patent/NZ306767A/xx not_active IP Right Cessation
- 1996-04-11 CA CA002217545A patent/CA2217545A1/en not_active Abandoned
- 1996-04-11 AU AU55412/96A patent/AU716893B2/en not_active Expired
- 1996-04-11 JP JP8531174A patent/JPH11502717A/ja not_active Withdrawn
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NZ502795A (en) | 2001-09-28 |
US20050053913A1 (en) | 2005-03-10 |
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US5955280A (en) | 1999-09-21 |
JP2007075107A (ja) | 2007-03-29 |
DE69636866D1 (en) | 2007-03-15 |
US20020197627A1 (en) | 2002-12-26 |
WO1996032503A1 (en) | 1996-10-17 |
EP0830459A1 (de) | 1998-03-25 |
US7033768B2 (en) | 2006-04-25 |
US7601533B2 (en) | 2009-10-13 |
US5965368A (en) | 1999-10-12 |
EP0830459A4 (de) | 2002-02-27 |
NZ306767A (en) | 2000-03-27 |
CA2217545A1 (en) | 1996-10-17 |
AU5541296A (en) | 1996-10-30 |
US20030124538A1 (en) | 2003-07-03 |
AU716893B2 (en) | 2000-03-09 |
EP0830459B1 (de) | 2007-01-24 |
US20030068612A1 (en) | 2003-04-10 |
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