EE03482B1 - Kinasoliiniderivaadid, nende valmistamismeetod ja kasutamine - Google Patents
Kinasoliiniderivaadid, nende valmistamismeetod ja kasutamineInfo
- Publication number
- EE03482B1 EE03482B1 EE9700252A EE9700252A EE03482B1 EE 03482 B1 EE03482 B1 EE 03482B1 EE 9700252 A EE9700252 A EE 9700252A EE 9700252 A EE9700252 A EE 9700252A EE 03482 B1 EE03482 B1 EE 03482B1
- Authority
- EE
- Estonia
- Prior art keywords
- preparation
- quinazoline derivatives
- quinazoline
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9508538.7A GB9508538D0 (en) | 1995-04-27 | 1995-04-27 | Quinazoline derivatives |
PCT/GB1996/000961 WO1996033980A1 (en) | 1995-04-27 | 1996-04-23 | Quinazoline derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
EE9700252A EE9700252A (et) | 1998-04-15 |
EE03482B1 true EE03482B1 (et) | 2001-08-15 |
Family
ID=10773597
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EE9700252A EE03482B1 (et) | 1995-04-27 | 1996-04-23 | Kinasoliiniderivaadid, nende valmistamismeetod ja kasutamine |
Country Status (38)
Country | Link |
---|---|
US (1) | US5770599A (cs) |
EP (1) | EP0823900B1 (cs) |
JP (1) | JP3040486B2 (cs) |
KR (1) | KR100296656B1 (cs) |
CN (1) | CN1100046C (cs) |
AR (1) | AR003944A1 (cs) |
AT (1) | ATE198329T1 (cs) |
AU (1) | AU699163B2 (cs) |
BG (1) | BG62730B1 (cs) |
BR (1) | BRPI9608082B8 (cs) |
CA (1) | CA2215732C (cs) |
CZ (1) | CZ288489B6 (cs) |
DE (2) | DE122009000076I1 (cs) |
DK (1) | DK0823900T3 (cs) |
EE (1) | EE03482B1 (cs) |
EG (1) | EG24134A (cs) |
ES (1) | ES2153098T3 (cs) |
FR (1) | FR09C0065I2 (cs) |
GB (1) | GB9508538D0 (cs) |
GR (1) | GR3035211T3 (cs) |
HR (1) | HRP960204B1 (cs) |
HU (1) | HU223313B1 (cs) |
IL (1) | IL118045A (cs) |
LU (1) | LU91631I2 (cs) |
MY (1) | MY114425A (cs) |
NL (1) | NL300429I1 (cs) |
NO (2) | NO309472B1 (cs) |
NZ (1) | NZ305444A (cs) |
PL (1) | PL189182B1 (cs) |
PT (1) | PT823900E (cs) |
RO (1) | RO117849B1 (cs) |
RU (1) | RU2153495C2 (cs) |
SI (1) | SI0823900T1 (cs) |
SK (1) | SK282236B6 (cs) |
TW (1) | TW436486B (cs) |
UA (1) | UA52602C2 (cs) |
WO (1) | WO1996033980A1 (cs) |
ZA (1) | ZA963358B (cs) |
Families Citing this family (737)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6811779B2 (en) | 1994-02-10 | 2004-11-02 | Imclone Systems Incorporated | Methods for reducing tumor growth with VEGF receptor antibody combined with radiation and chemotherapy |
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DE69613367T2 (de) * | 1995-04-27 | 2002-04-18 | Astrazeneca Ab, Soedertaelje | Chinazolin derivate |
GB9508565D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quiazoline derivative |
GB9508535D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivative |
GB9508537D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
US7060808B1 (en) * | 1995-06-07 | 2006-06-13 | Imclone Systems Incorporated | Humanized anti-EGF receptor monoclonal antibody |
GB9624482D0 (en) * | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
SI0880508T1 (en) | 1996-02-13 | 2003-10-31 | Astrazeneca Ab | Quinazoline derivatives as vegf inhibitors |
GB9603097D0 (en) * | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline compounds |
GB9603095D0 (en) * | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
KR100489174B1 (ko) | 1996-03-05 | 2005-09-30 | 제네카-파마 소시에떼아노님 | 4-아닐리노퀴나졸린유도체 |
RO121900B1 (ro) | 1996-04-12 | 2008-07-30 | Warner-Lambert Company | Compuşi inhibitori, ireversibili, ai tirozin kinazelor, compoziţie farmaceutică care îi conţine şi utilizarea acestora |
GB9607729D0 (en) * | 1996-04-13 | 1996-06-19 | Zeneca Ltd | Quinazoline derivatives |
GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
KR100612161B1 (ko) † | 1997-08-15 | 2006-08-14 | 세파론, 인코포레이티드 | 전립선암 치료를 위한 티로신 키나아제 억제제 및 화학적거세법의 조합 |
DE69838172T2 (de) | 1997-08-22 | 2008-04-10 | Astrazeneca Ab | Oxindolylchinazolinderivate als angiogenesehemmer |
US20030224001A1 (en) * | 1998-03-19 | 2003-12-04 | Goldstein Neil I. | Antibody and antibody fragments for inhibiting the growth of tumors |
US6864227B1 (en) | 1998-04-13 | 2005-03-08 | California Institute Of Technology | Artery-and vein-specific proteins and uses therefor |
US6887674B1 (en) * | 1998-04-13 | 2005-05-03 | California Institute Of Technology | Artery- and vein-specific proteins and uses therefor |
ZA200007412B (en) * | 1998-05-15 | 2002-03-12 | Imclone Systems Inc | Treatment of human tumors with radiation and inhibitors of growth factor receptor tyrosine kinases. |
US7354894B2 (en) * | 1998-08-18 | 2008-04-08 | The Regents Of The University Of California | Preventing airway mucus production by administration of EGF-R antagonists |
EA004316B1 (ru) | 1998-08-18 | 2004-02-26 | Дзе Реджентс Ов Дзе Юниверсити Ов Калифорния | Способ лечения гиперсекреции слизи |
US6313129B1 (en) | 1998-08-21 | 2001-11-06 | Hughes Institute | Therapeutic compounds |
EP2896612A1 (en) | 1998-09-29 | 2015-07-22 | Wyeth Holdings LLC | Substituted 3-cyanoquinolines as protein tyrosine kinases inhibitors |
US6288082B1 (en) | 1998-09-29 | 2001-09-11 | American Cyanamid Company | Substituted 3-cyanoquinolines |
US6297258B1 (en) | 1998-09-29 | 2001-10-02 | American Cyanamid Company | Substituted 3-cyanoquinolines |
ATE293989T1 (de) * | 1998-11-20 | 2005-05-15 | Genentech Inc | Verwendung von eph-rezeptor-antagonisten und agonisten zur behandlung von vaskulären krankheiten |
PL351619A1 (en) | 1999-02-27 | 2003-05-19 | Boehringer Ingelheim Pharma | 4-amino-quinazoline and quinoline derivatives having an inhibitory effect on signal transsduction mediated by tyrosine kinases |
DE19911509A1 (de) * | 1999-03-15 | 2000-09-21 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
HK1047236A1 (zh) * | 1999-05-14 | 2003-02-14 | Imclone Llc | 用表皮生长因子受体拮抗剂治疗难治的人肿瘤 |
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DE60121931T2 (de) | 2000-04-07 | 2007-03-01 | Astrazeneca Ab | Chinazolinverbindungen |
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DE60134679D1 (de) | 2000-10-20 | 2008-08-14 | Eisai R&D Man Co Ltd | Stickstoff enthaltende aromatische Heterozyklen |
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