BR0015203A - Derivado de quinazolina, processo para a preparação de um derivado de quinazolina, composição farmacêutica, uso de um composto, e, processo para a produção de um efeito antiangiogênico e/ou redutor de permeabilidade vascular em um animal de sangue quente - Google Patents

Derivado de quinazolina, processo para a preparação de um derivado de quinazolina, composição farmacêutica, uso de um composto, e, processo para a produção de um efeito antiangiogênico e/ou redutor de permeabilidade vascular em um animal de sangue quente

Info

Publication number
BR0015203A
BR0015203A BR0015203-0A BR0015203A BR0015203A BR 0015203 A BR0015203 A BR 0015203A BR 0015203 A BR0015203 A BR 0015203A BR 0015203 A BR0015203 A BR 0015203A
Authority
BR
Brazil
Prior art keywords
quinazoline derivative
compound
preparation
alkyl
pharmaceutical composition
Prior art date
Application number
BR0015203-0A
Other languages
English (en)
Inventor
Laurent Francois And Hennequin
Elaine Sophie Elizabeth Stokes
Andrew Peter Thomas
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26153696&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0015203(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BR0015203A publication Critical patent/BR0015203A/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"DERIVADO DE QUINAZOLINA, PROCESSO PARA A PREPARAçãO DE UM DERIVADO DE QUINAZOLINA, COMPOSIçãO FARMACêUTICA, USO DE UM COMPOSTO, E, PROCESSO PARA A PRODUçãO DE UM EFEITO ANTIANGIOGêNICO E/OU REDUTOR DE PERMEABILIDADE VASCULAR EM UM ANIMAL DE SANGUE QUENTE" A invenção refere-se a derivados de quinazolina de fórmula (I) em que m é um número inteiro de 1 a 3; R^ 1^ representa halogênio ou C~ 1-3~ alquila; X^ 1^ representa -O-; R^ 2^ é selecionado de um dos três grupos a seguir: 1) C~ 1-5~ alquila R^ 3^ (em que R^ 3^ é piperidin-4-ila que pode portar um ou dois substituintes selecionados dentre hidróxi, halogênio, C~ 1-4~ alquila, C~ 1-4~ hidroxialquila e C~ 1-4~ alcóxi; 2) C~ 2-5~ alquenila R^ 3^ (em que R^ 3^ é como definido previamente); 3) C~ 2-5~ alquinila R^ 3^ (em que R^ 3^ é como definido previamente); e em que qualquer grupo alquila, alquenila ou alquinila pode portar um ou mais substituintes selecionados dentre hidróxi, halogênio e amino; e sais dos mesmos; processos para sua preparação, composições farmacêuticas contendo um composto de fórmula (I) ou um seu sal farmaceuticamente aceitável como ingrediente ativo. Os compostos de fórmula (I) e os seus sais farmaceuticamente aceitáveis inibem os efeitos de VEGF, uma propriedade valiosa no tratamento de uma quantidade de estados de doença, incluindo câncer e artrite reumatóide.
BR0015203-0A 1999-11-05 2000-11-01 Derivado de quinazolina, processo para a preparação de um derivado de quinazolina, composição farmacêutica, uso de um composto, e, processo para a produção de um efeito antiangiogênico e/ou redutor de permeabilidade vascular em um animal de sangue quente BR0015203A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99402759 1999-11-05
EP99402877 1999-11-19
PCT/GB2000/004181 WO2001032651A1 (en) 1999-11-05 2000-11-01 Quinazoline derivatives as vegf inhibitors

Publications (1)

Publication Number Publication Date
BR0015203A true BR0015203A (pt) 2002-07-16

Family

ID=26153696

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0015203A BRPI0015203B8 (pt) 1999-11-05 2000-11-01 derivado de quinazolina, composição farmacêutica, e, uso de um composto
BR0015203-0A BR0015203A (pt) 1999-11-05 2000-11-01 Derivado de quinazolina, processo para a preparação de um derivado de quinazolina, composição farmacêutica, uso de um composto, e, processo para a produção de um efeito antiangiogênico e/ou redutor de permeabilidade vascular em um animal de sangue quente

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BRPI0015203A BRPI0015203B8 (pt) 1999-11-05 2000-11-01 derivado de quinazolina, composição farmacêutica, e, uso de um composto

Country Status (36)

Country Link
US (9) US7173038B1 (pt)
EP (2) EP1244647B1 (pt)
JP (1) JP3522727B2 (pt)
KR (3) KR100849151B1 (pt)
CN (2) CN100376567C (pt)
AR (1) AR033499A1 (pt)
AT (2) ATE330954T1 (pt)
AU (1) AU769222B2 (pt)
BE (1) BE2012C036I2 (pt)
BG (1) BG65861B1 (pt)
BR (2) BRPI0015203B8 (pt)
CA (1) CA2389767C (pt)
CY (3) CY1106166T1 (pt)
CZ (1) CZ301689B6 (pt)
DE (2) DE60039206D1 (pt)
DK (2) DK1244647T3 (pt)
EE (1) EE05330B1 (pt)
ES (2) ES2265998T3 (pt)
FR (1) FR12C0048I2 (pt)
HK (2) HK1049664B (pt)
HU (1) HU229414B1 (pt)
IL (2) IL149034A0 (pt)
IS (2) IS2284B (pt)
LU (1) LU92057I2 (pt)
MX (1) MXPA02004366A (pt)
NO (2) NO322298B1 (pt)
NZ (1) NZ518028A (pt)
PL (1) PL203782B1 (pt)
PT (2) PT1676845E (pt)
RU (1) RU2291868C2 (pt)
SI (2) SI1676845T1 (pt)
SK (1) SK287401B6 (pt)
TW (1) TWI287540B (pt)
UA (1) UA72946C2 (pt)
WO (1) WO2001032651A1 (pt)
ZA (1) ZA200202775B (pt)

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