CY1108256T1 - Νεα παραγωγα κουιναζολινης - Google Patents
Νεα παραγωγα κουιναζολινηςInfo
- Publication number
- CY1108256T1 CY1108256T1 CY20081100853T CY081100853T CY1108256T1 CY 1108256 T1 CY1108256 T1 CY 1108256T1 CY 20081100853 T CY20081100853 T CY 20081100853T CY 081100853 T CY081100853 T CY 081100853T CY 1108256 T1 CY1108256 T1 CY 1108256T1
- Authority
- CY
- Cyprus
- Prior art keywords
- formula
- hydroxy
- alkyl
- pharmaceutically acceptable
- defined above
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Reproductive Health (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Η εφεύρεση αναφέρεται σε παράγωγα κουιναζολίνης του τύπου (I) όπου το m είναι ένας ακέραιος από 1 έως 3· το R1 αντιπροσωπεύει αλογόνο ή C1-3αλκυλ∙ το Χ1 αντιπροσωπεύει -Ο-· το R2 επιλέγεται από μία από τις ακόλουθες τρεις ομάδες: 1) C1-5αλκυλR3 (όπου το R3 είναι πιπεριδιν-4-υλ το οποίο μπορεί να φέρει έναν ή δύο υποκατάστατες που επιλέγονται από υδροξυ, αλογόνο, C1-4αλκυλ, C1-4υδροξυαλκυλ και C1-4αλκοξυ· 2) C2-5αλκενυλR3 (όπου το R3 είναι όπως ορίστηκε παραπάνω)· 3) C2-5αλκυνυλR3 (όπου το R3 είναι όπως ορίστηκε παραπάνω)· και όπου οποιαδήποτε αλκυλ, αλκενυλ ή αλκυνυλ ομάδα μπορεί να φέρει έναν ή περισσότερους υποκατάστατες που επιλέγονται από υδροξυ, αλογόνο και αμινο· και άλατα αυτών· διαδικασίες για την παρασκευή τους, φαρμακευτικές συνθέσεις που περιέχουν μία ένωση του τύπου (I) ή ένα φαρμακευτικώς ανεκτό άλας αυτής ως δραστικό συστατικό. Οι ενώσεις του τύπου (I) και τα φαρμακευτικώς ανεκτά άλατα αυτών αναστέλλουν τις επιδράσεις του VEGF, μία σημαντική ιδιότητα για τη θεραπευτική αντιμετώπιση πολλών ασθενειών στις οποίες περιλαμβάνονται ο καρκίνος και η ρευματοειδής αρθρίτιδα.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99402759 | 1999-11-05 | ||
| EP99402877 | 1999-11-19 | ||
| EP06004921A EP1676845B1 (en) | 1999-11-05 | 2000-11-01 | New quinazoline derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1108256T1 true CY1108256T1 (el) | 2014-02-12 |
Family
ID=26153696
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20061101355T CY1106166T1 (el) | 1999-11-05 | 2006-09-21 | Παραγωγα κουιναζολινης ως αναστολεις vegf. |
| CY20081100853T CY1108256T1 (el) | 1999-11-05 | 2008-08-12 | Νεα παραγωγα κουιναζολινης |
| CY2012026C CY2012026I1 (el) | 1999-11-05 | 2012-08-14 | Παραγωγα κουιναζολινης ως αναστολεις vegf |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20061101355T CY1106166T1 (el) | 1999-11-05 | 2006-09-21 | Παραγωγα κουιναζολινης ως αναστολεις vegf. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY2012026C CY2012026I1 (el) | 1999-11-05 | 2012-08-14 | Παραγωγα κουιναζολινης ως αναστολεις vegf |
Country Status (36)
| Country | Link |
|---|---|
| US (9) | US7173038B1 (el) |
| EP (2) | EP1244647B1 (el) |
| JP (1) | JP3522727B2 (el) |
| KR (3) | KR100881105B1 (el) |
| CN (2) | CN101219145A (el) |
| AR (1) | AR033499A1 (el) |
| AT (2) | ATE398120T1 (el) |
| AU (1) | AU769222B2 (el) |
| BE (1) | BE2012C036I2 (el) |
| BG (1) | BG65861B1 (el) |
| BR (2) | BRPI0015203B8 (el) |
| CA (1) | CA2389767C (el) |
| CY (3) | CY1106166T1 (el) |
| CZ (1) | CZ301689B6 (el) |
| DE (2) | DE60039206D1 (el) |
| DK (2) | DK1676845T3 (el) |
| EE (1) | EE05330B1 (el) |
| ES (2) | ES2265998T3 (el) |
| FR (1) | FR12C0048I2 (el) |
| HK (2) | HK1049664B (el) |
| HU (1) | HU229414B1 (el) |
| IL (2) | IL149034A0 (el) |
| IS (2) | IS2284B (el) |
| LU (1) | LU92057I2 (el) |
| MX (1) | MXPA02004366A (el) |
| NO (2) | NO322298B1 (el) |
| NZ (1) | NZ518028A (el) |
| PL (1) | PL203782B1 (el) |
| PT (2) | PT1244647E (el) |
| RU (1) | RU2291868C2 (el) |
| SI (2) | SI1676845T1 (el) |
| SK (1) | SK287401B6 (el) |
| TW (1) | TWI287540B (el) |
| UA (1) | UA72946C2 (el) |
| WO (1) | WO2001032651A1 (el) |
| ZA (1) | ZA200202775B (el) |
Families Citing this family (221)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| PT1244647E (pt) | 1999-11-05 | 2006-10-31 | Astrazeneca Ab | Derivados de quinazolina como inibidores de vegf |
| GB0008269D0 (en) * | 2000-04-05 | 2000-05-24 | Astrazeneca Ab | Combination chemotherapy |
| GB0126879D0 (en) * | 2001-11-08 | 2002-01-02 | Astrazeneca Ab | Combination therapy |
| EP1482975B1 (en) * | 2002-01-29 | 2006-12-13 | Vlaams Interuniversitair Instituut voor Biotechnologie vzw. | Prevention of tissue adhesion |
| CN101607958A (zh) * | 2002-02-01 | 2009-12-23 | 阿斯特拉曾尼卡有限公司 | 喹唑啉化合物 |
| US6924285B2 (en) | 2002-03-30 | 2005-08-02 | Boehringer Ingelheim Pharma Gmbh & Co. | Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them |
| ES2400339T3 (es) | 2002-07-15 | 2013-04-09 | Symphony Evolution, Inc. | Compuestos, composiciones farmacéuticas de los mismos y su uso en el tratamiento del cáncer |
| CA2495487A1 (en) * | 2002-08-09 | 2004-02-19 | Astrazeneca Ab | Combination of zd6474, an inhibitor of the vascular endothelial growth factor receptor, with radiotherapy in the treatment of cancer |
| DE10237423A1 (de) | 2002-08-16 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von LCK-Inhibitoren für die Behandlung von immunologischen Erkrankungen |
| GB0223380D0 (en) * | 2002-10-09 | 2002-11-13 | Astrazeneca Ab | Combination therapy |
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| WO2004071397A2 (en) * | 2003-02-13 | 2004-08-26 | Astrazeneca Ab | Combination therapy of zd6474 with 5-fu or/and cpt-11 |
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- 2002-04-26 BG BG106659A patent/BG65861B1/bg unknown
- 2002-05-03 NO NO20022139A patent/NO322298B1/no not_active IP Right Cessation
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2003
- 2003-03-07 HK HK03101686.4A patent/HK1049664B/zh not_active IP Right Cessation
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2006
- 2006-09-21 CY CY20061101355T patent/CY1106166T1/el unknown
- 2006-12-08 HK HK06113553A patent/HK1092804A1/xx unknown
- 2006-12-21 US US11/642,979 patent/US20070265286A1/en not_active Abandoned
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2007
- 2007-09-04 IS IS8673A patent/IS2556B/is unknown
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2008
- 2008-08-12 CY CY20081100853T patent/CY1108256T1/el unknown
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2010
- 2010-04-15 US US12/761,105 patent/US8642608B2/en not_active Expired - Lifetime
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2012
- 2012-08-07 LU LU92057C patent/LU92057I2/fr unknown
- 2012-08-07 NO NO2012014C patent/NO2012014I1/no unknown
- 2012-08-09 BE BE2012C036C patent/BE2012C036I2/fr unknown
- 2012-08-09 FR FR12C0048C patent/FR12C0048I2/fr active Active
- 2012-08-14 CY CY2012026C patent/CY2012026I1/el unknown
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2014
- 2014-01-03 US US14/146,954 patent/US9040548B2/en not_active Expired - Fee Related
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2015
- 2015-05-22 US US14/719,779 patent/US20160130249A1/en not_active Abandoned
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2017
- 2017-06-19 US US15/626,576 patent/US20180099946A1/en not_active Abandoned
- 2017-12-28 US US15/856,235 patent/US10457664B2/en not_active Expired - Fee Related
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2019
- 2019-09-25 US US16/582,469 patent/US20200262811A1/en not_active Abandoned
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2021
- 2021-01-15 US US17/150,856 patent/US20210276972A1/en not_active Abandoned
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