SK282236B6 - Chinazolínové deriváty, spôsob ich prípravy, farmaceutický prostriedok, ktorý ich obsahuje a ich použitie - Google Patents
Chinazolínové deriváty, spôsob ich prípravy, farmaceutický prostriedok, ktorý ich obsahuje a ich použitie Download PDFInfo
- Publication number
- SK282236B6 SK282236B6 SK1454-97A SK145497A SK282236B6 SK 282236 B6 SK282236 B6 SK 282236B6 SK 145497 A SK145497 A SK 145497A SK 282236 B6 SK282236 B6 SK 282236B6
- Authority
- SK
- Slovakia
- Prior art keywords
- formula
- chloro
- quinazoline
- pharmaceutically acceptable
- fluoroanilino
- Prior art date
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- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 title abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 74
- 150000003839 salts Chemical class 0.000 claims abstract description 57
- -1 2-dimethylaminoethoxy, 2-diethylaminoethoxy, 3-dimethylaminopropoxy, 3-diethylaminopropoxy, 2- (pyrrolidin-1-yl) ethoxy, 3- (pyrrolidin-1-yl) propoxy, 2-piperidino 3-piperidinopropoxy Chemical group 0.000 claims abstract description 54
- 239000002253 acid Substances 0.000 claims abstract description 40
- 238000000034 method Methods 0.000 claims abstract description 15
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims abstract description 7
- 239000003814 drug Substances 0.000 claims abstract description 5
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 5
- 230000008569 process Effects 0.000 claims abstract description 5
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- 230000001028 anti-proliverative effect Effects 0.000 claims description 15
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- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical compound N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 claims description 6
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- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
- 229960004355 vindesine Drugs 0.000 description 1
- UGGWPQSBPIFKDZ-KOTLKJBCSA-N vindesine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(N)=O)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1N=C1[C]2C=CC=C1 UGGWPQSBPIFKDZ-KOTLKJBCSA-N 0.000 description 1
- GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 description 1
- 229960002066 vinorelbine Drugs 0.000 description 1
- 201000004916 vulva carcinoma Diseases 0.000 description 1
- 208000013013 vulvar carcinoma Diseases 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9508538.7A GB9508538D0 (en) | 1995-04-27 | 1995-04-27 | Quinazoline derivatives |
| PCT/GB1996/000961 WO1996033980A1 (en) | 1995-04-27 | 1996-04-23 | Quinazoline derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK145497A3 SK145497A3 (en) | 1998-02-04 |
| SK282236B6 true SK282236B6 (sk) | 2001-12-03 |
Family
ID=10773597
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1454-97A SK282236B6 (sk) | 1995-04-27 | 1996-04-23 | Chinazolínové deriváty, spôsob ich prípravy, farmaceutický prostriedok, ktorý ich obsahuje a ich použitie |
Country Status (38)
| Country | Link |
|---|---|
| US (1) | US5770599A (cs) |
| EP (1) | EP0823900B1 (cs) |
| JP (1) | JP3040486B2 (cs) |
| KR (1) | KR100296656B1 (cs) |
| CN (1) | CN1100046C (cs) |
| AR (1) | AR003944A1 (cs) |
| AT (1) | ATE198329T1 (cs) |
| AU (1) | AU699163B2 (cs) |
| BG (1) | BG62730B1 (cs) |
| BR (1) | BRPI9608082B8 (cs) |
| CA (1) | CA2215732C (cs) |
| CZ (1) | CZ288489B6 (cs) |
| DE (2) | DE122009000076I1 (cs) |
| DK (1) | DK0823900T3 (cs) |
| EE (1) | EE03482B1 (cs) |
| EG (1) | EG24134A (cs) |
| ES (1) | ES2153098T3 (cs) |
| FR (1) | FR09C0065I2 (cs) |
| GB (1) | GB9508538D0 (cs) |
| GR (1) | GR3035211T3 (cs) |
| HR (1) | HRP960204B1 (cs) |
| HU (1) | HU223313B1 (cs) |
| IL (1) | IL118045A (cs) |
| LU (1) | LU91631I2 (cs) |
| MY (1) | MY114425A (cs) |
| NL (1) | NL300429I1 (cs) |
| NO (2) | NO309472B1 (cs) |
| NZ (1) | NZ305444A (cs) |
| PL (1) | PL189182B1 (cs) |
| PT (1) | PT823900E (cs) |
| RO (1) | RO117849B1 (cs) |
| RU (1) | RU2153495C2 (cs) |
| SI (1) | SI0823900T1 (cs) |
| SK (1) | SK282236B6 (cs) |
| TW (1) | TW436486B (cs) |
| UA (1) | UA52602C2 (cs) |
| WO (1) | WO1996033980A1 (cs) |
| ZA (1) | ZA963358B (cs) |
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| TW321649B (cs) * | 1994-11-12 | 1997-12-01 | Zeneca Ltd | |
| GB9424233D0 (en) * | 1994-11-30 | 1995-01-18 | Zeneca Ltd | Quinazoline derivatives |
| AU5343096A (en) * | 1995-04-27 | 1996-11-18 | Zeneca Limited | Quinazoline derivatives |
| GB9508565D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quiazoline derivative |
| GB9508535D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivative |
| GB9508537D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| US7060808B1 (en) * | 1995-06-07 | 2006-06-13 | Imclone Systems Incorporated | Humanized anti-EGF receptor monoclonal antibody |
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| CN1125817C (zh) | 1996-02-13 | 2003-10-29 | 曾尼卡有限公司 | 作为vegf抑制剂的喹唑啉衍生物 |
| GB9603097D0 (en) * | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline compounds |
| GB9603095D0 (en) * | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
| CN1116286C (zh) | 1996-03-05 | 2003-07-30 | 曾尼卡有限公司 | 4－苯胺基喹唑啉衍生物 |
| SI0892789T2 (sl) | 1996-04-12 | 2010-03-31 | Warner Lambert Co | Ireverzibilni inhibitorji tirozin kinaz |
| GB9607729D0 (en) * | 1996-04-13 | 1996-06-19 | Zeneca Ltd | Quinazoline derivatives |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| UA61970C2 (en) † | 1997-08-15 | 2003-12-15 | Combined use of tyrosine kinase inhibitor and a chemical castration agent for treating prostate cancer | |
| DE69838172T2 (de) | 1997-08-22 | 2008-04-10 | Astrazeneca Ab | Oxindolylchinazolinderivate als angiogenesehemmer |
| US20030224001A1 (en) * | 1998-03-19 | 2003-12-04 | Goldstein Neil I. | Antibody and antibody fragments for inhibiting the growth of tumors |
| US6864227B1 (en) * | 1998-04-13 | 2005-03-08 | California Institute Of Technology | Artery-and vein-specific proteins and uses therefor |
| US6887674B1 (en) * | 1998-04-13 | 2005-05-03 | California Institute Of Technology | Artery- and vein-specific proteins and uses therefor |
| ZA200007412B (en) * | 1998-05-15 | 2002-03-12 | Imclone Systems Inc | Treatment of human tumors with radiation and inhibitors of growth factor receptor tyrosine kinases. |
| US7354894B2 (en) * | 1998-08-18 | 2008-04-08 | The Regents Of The University Of California | Preventing airway mucus production by administration of EGF-R antagonists |
| PL200940B1 (pl) | 1998-08-18 | 2009-02-27 | Univ California | Zastosowanie antagonisty receptora naskórkowego czynnika wzrostowego (EGF-R) i postać farmaceutyczna do leczenia nadmiernego wydzielania śluzu dróg oddechowych |
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| PT2253620E (pt) | 1998-09-29 | 2014-04-15 | Wyeth Holdings Llc | 3-cianoquinolinas substituídas como inibidores de proteínas tirosinas quinases |
| US6288082B1 (en) | 1998-09-29 | 2001-09-11 | American Cyanamid Company | Substituted 3-cyanoquinolines |
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Free format text: PRODUCT NAME: GEFITINIB; REG. NO/DATE: EU/1/09/526/001 20090624 Spc suppl protection certif: 5009-2009 Filing date: 20091215 |
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| MK4A | Patent expired |
Expiry date: 20160423 |
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| SPCE | Expiry of an spc |
Spc suppl protection certif: 85, PDO 5010-2009 Effective date: 20190302 |