BR112014015274A8 - compostos e composições para inibição da interação de bcl2 com parceiros de ligação - Google Patents

compostos e composições para inibição da interação de bcl2 com parceiros de ligação

Info

Publication number
BR112014015274A8
BR112014015274A8 BR112014015274A BR112014015274A BR112014015274A8 BR 112014015274 A8 BR112014015274 A8 BR 112014015274A8 BR 112014015274 A BR112014015274 A BR 112014015274A BR 112014015274 A BR112014015274 A BR 112014015274A BR 112014015274 A8 BR112014015274 A8 BR 112014015274A8
Authority
BR
Brazil
Prior art keywords
compounds
bcl
interaction
compositions
binding partners
Prior art date
Application number
BR112014015274A
Other languages
English (en)
Other versions
BR112014015274A2 (pt
Inventor
Scott Visser Michael
Yusuff Naeem
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BR112014015274A2 publication Critical patent/BR112014015274A2/pt
Publication of BR112014015274A8 publication Critical patent/BR112014015274A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

compounds and compositions for inhibiting the interaction of bcl2 with binding partners abstract the present invention relates to compounds of formula i: in which r1, r2, r3 and r4 are as defined in the summary of the invention. compounds of formula i are capable of disrupting the bcl-2 interations with proteins containing a bh3 domain. disrupting this interaction can restore the anti-apoptotic function of bcl-2 in cancer cells and tumor tissue expressing bcl-2. the invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancerous diseases. ****************************************** tradução do resumo resumo patente de invenção: “compostos e composições para inibição da interação de bcl2 com parceiros de ligação" a presente invenção refere-se a compostos de fórmula i: na qual r1, r2, r3 e r4 são conforme definido no sumário da invenção. compostos de fórmula i são capazes de romper as interações de bcl-2 com proteínas contendo um domínio bh3. ruptura desta interação pode restaurar a função anti-apoptótica de bcl-2 em células cancerosas e tecido de tumor que expressam bcl-2. a invenção fornece ainda um processo para o preparo de compostos da invenção, preparados farmacêuticos compreendendo tais compostos e métodos de uso de tais compostos no tratamento de doenças cancerosas. 54943 - 2 - 21607246v1
BR112014015274A 2011-12-23 2012-12-12 compostos e composições para inibição da interação de bcl2 com parceiros de ligação BR112014015274A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161579731P 2011-12-23 2011-12-23
PCT/US2012/069181 WO2013096049A1 (en) 2011-12-23 2012-12-12 Compounds for inhibiting the interaction of bcl2 with binding partners

Publications (2)

Publication Number Publication Date
BR112014015274A2 BR112014015274A2 (pt) 2017-06-13
BR112014015274A8 true BR112014015274A8 (pt) 2017-06-13

Family

ID=47429049

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014015274A BR112014015274A8 (pt) 2011-12-23 2012-12-12 compostos e composições para inibição da interação de bcl2 com parceiros de ligação

Country Status (11)

Country Link
US (1) US9126980B2 (pt)
EP (1) EP2794588A1 (pt)
JP (1) JP2015503515A (pt)
KR (1) KR20140107573A (pt)
CN (1) CN104125955A (pt)
AU (1) AU2012355613A1 (pt)
BR (1) BR112014015274A8 (pt)
CA (1) CA2859862A1 (pt)
EA (1) EA201491268A1 (pt)
MX (1) MX2014007729A (pt)
WO (1) WO2013096049A1 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
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CN104125954A (zh) 2011-12-23 2014-10-29 诺华股份有限公司 用于抑制bcl2与结合配偶体相互作用的化合物
FR3008976A1 (fr) 2013-07-23 2015-01-30 Servier Lab "nouveaux derives d'indolizine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent"
FR3008978A1 (fr) * 2013-07-23 2015-01-30 Servier Lab "nouveaux derives d'indole et de pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent"
FR3008979B1 (fr) 2013-07-23 2015-07-24 Servier Lab Nouveaux derives phosphates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US10195213B2 (en) 2015-03-13 2019-02-05 Unity Biotechnology, Inc. Chemical entities that kill senescent cells for use in treating age-related disease
KR20200094734A (ko) 2017-09-22 2020-08-07 주빌런트 에피파드 엘엘씨 Pad 억제제로서의 헤테로사이클릭 화합물
DK3697785T3 (da) 2017-10-18 2023-04-03 Jubilant Epipad LLC Imidazo-pyridine forbindelser som pad-inhibitorer
AU2018362046B2 (en) 2017-11-06 2023-04-13 Jubilant Prodel LLC Pyrimidine derivatives as inhibitors of PD1/PD-L1 activation
CA3083374A1 (en) 2017-11-24 2019-05-31 Jubilant Episcribe Llc Heterocyclic compounds as prmt5 inhibitors
AU2019234185A1 (en) 2018-03-13 2020-10-01 Jubilant Prodel LLC. Bicyclic compounds as inhibitors of PD1/PD-L1 interaction/activation
EP3788042A4 (en) 2018-04-29 2022-01-26 BeiGene, Ltd. BCL-2 INHIBITORS

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Also Published As

Publication number Publication date
CN104125955A (zh) 2014-10-29
US20150080428A1 (en) 2015-03-19
KR20140107573A (ko) 2014-09-04
EP2794588A1 (en) 2014-10-29
CA2859862A1 (en) 2013-06-27
WO2013096049A1 (en) 2013-06-27
AU2012355613A1 (en) 2014-07-17
MX2014007729A (es) 2015-01-12
EA201491268A1 (ru) 2014-11-28
JP2015503515A (ja) 2015-02-02
BR112014015274A2 (pt) 2017-06-13
US9126980B2 (en) 2015-09-08

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B350 Update of information on the portal [chapter 15.35 patent gazette]