EA201491268A1 - Соединения и композиции для ингибирования взаимодействия bcl2 с партнерами по связыванию - Google Patents
Соединения и композиции для ингибирования взаимодействия bcl2 с партнерами по связываниюInfo
- Publication number
- EA201491268A1 EA201491268A1 EA201491268A EA201491268A EA201491268A1 EA 201491268 A1 EA201491268 A1 EA 201491268A1 EA 201491268 A EA201491268 A EA 201491268A EA 201491268 A EA201491268 A EA 201491268A EA 201491268 A1 EA201491268 A1 EA 201491268A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compounds
- interaction
- bcl2
- partners
- linkage
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Изобретение относится к соединениям формулы (I), в которой R, R, Rи Rопределены в описании изобретения. Соединения формулы (I) способны нарушать BCL-2 взаимодействия с белками, содержащими ВН3 домен. Нарушение данного взаимодействия может восстанавливать антиапоптозную функцию BCL-2 в раковых клетках и опухолевой ткани, экспрессирующих BCL-2. Кроме того, изобретение относится к способу получения соединений, фармацевтических препаратов, содержащих данные соединения, и способам применения данных соединений в лечении раковых заболеваний.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161579731P | 2011-12-23 | 2011-12-23 | |
PCT/US2012/069181 WO2013096049A1 (en) | 2011-12-23 | 2012-12-12 | Compounds for inhibiting the interaction of bcl2 with binding partners |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201491268A1 true EA201491268A1 (ru) | 2014-11-28 |
Family
ID=47429049
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201491268A EA201491268A1 (ru) | 2011-12-23 | 2012-12-12 | Соединения и композиции для ингибирования взаимодействия bcl2 с партнерами по связыванию |
Country Status (11)
Country | Link |
---|---|
US (1) | US9126980B2 (ru) |
EP (1) | EP2794588A1 (ru) |
JP (1) | JP2015503515A (ru) |
KR (1) | KR20140107573A (ru) |
CN (1) | CN104125955A (ru) |
AU (1) | AU2012355613A1 (ru) |
BR (1) | BR112014015274A8 (ru) |
CA (1) | CA2859862A1 (ru) |
EA (1) | EA201491268A1 (ru) |
MX (1) | MX2014007729A (ru) |
WO (1) | WO2013096049A1 (ru) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104125954A (zh) | 2011-12-23 | 2014-10-29 | 诺华股份有限公司 | 用于抑制bcl2与结合配偶体相互作用的化合物 |
FR3008978A1 (fr) * | 2013-07-23 | 2015-01-30 | Servier Lab | "nouveaux derives d'indole et de pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent" |
FR3008979B1 (fr) | 2013-07-23 | 2015-07-24 | Servier Lab | Nouveaux derives phosphates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
FR3008976A1 (fr) | 2013-07-23 | 2015-01-30 | Servier Lab | "nouveaux derives d'indolizine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent" |
US10195213B2 (en) | 2015-03-13 | 2019-02-05 | Unity Biotechnology, Inc. | Chemical entities that kill senescent cells for use in treating age-related disease |
KR20200094734A (ko) | 2017-09-22 | 2020-08-07 | 주빌런트 에피파드 엘엘씨 | Pad 억제제로서의 헤테로사이클릭 화합물 |
MX2020003341A (es) | 2017-10-18 | 2020-09-17 | Jubilant Epipad LLC | Compuestos de imidazo-piridina como inhibidores de pad. |
JP7279057B6 (ja) | 2017-11-06 | 2024-02-15 | ジュビラント プローデル エルエルシー | Pd1/pd-l1活性化の阻害剤としてのピリミジン誘導体 |
EP3704120B1 (en) | 2017-11-24 | 2024-03-06 | Jubilant Episcribe LLC | Heterocyclic compounds as prmt5 inhibitors |
MX2020009517A (es) | 2018-03-13 | 2021-01-20 | Jubilant Prodel LLC | Compuestos biciclicos como inhibidores de la interaccion/activacio n de pdl/pd-l1. |
WO2019210828A1 (en) | 2018-04-29 | 2019-11-07 | Beigene, Ltd. | Bcl-2 INHIBITORS |
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MX2014007725A (es) | 2011-12-23 | 2015-01-12 | Novartis Ag | Compuestos para inhibir la interaccion de bcl2 con los componentes de enlace. |
CN104125954A (zh) | 2011-12-23 | 2014-10-29 | 诺华股份有限公司 | 用于抑制bcl2与结合配偶体相互作用的化合物 |
CN104136429A (zh) | 2011-12-23 | 2014-11-05 | 诺华股份有限公司 | 用于抑制bcl2与结合配偶体相互作用的化合物 |
-
2012
- 2012-12-12 CA CA2859862A patent/CA2859862A1/en not_active Abandoned
- 2012-12-12 JP JP2014549133A patent/JP2015503515A/ja active Pending
- 2012-12-12 BR BR112014015274A patent/BR112014015274A8/pt not_active Application Discontinuation
- 2012-12-12 US US14/366,858 patent/US9126980B2/en not_active Expired - Fee Related
- 2012-12-12 EP EP12805893.0A patent/EP2794588A1/en not_active Withdrawn
- 2012-12-12 WO PCT/US2012/069181 patent/WO2013096049A1/en active Application Filing
- 2012-12-12 MX MX2014007729A patent/MX2014007729A/es unknown
- 2012-12-12 CN CN201280070506.9A patent/CN104125955A/zh active Pending
- 2012-12-12 KR KR1020147020518A patent/KR20140107573A/ko not_active Application Discontinuation
- 2012-12-12 EA EA201491268A patent/EA201491268A1/ru unknown
- 2012-12-12 AU AU2012355613A patent/AU2012355613A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CN104125955A (zh) | 2014-10-29 |
BR112014015274A2 (pt) | 2017-06-13 |
CA2859862A1 (en) | 2013-06-27 |
US9126980B2 (en) | 2015-09-08 |
AU2012355613A1 (en) | 2014-07-17 |
EP2794588A1 (en) | 2014-10-29 |
KR20140107573A (ko) | 2014-09-04 |
BR112014015274A8 (pt) | 2017-06-13 |
JP2015503515A (ja) | 2015-02-02 |
US20150080428A1 (en) | 2015-03-19 |
WO2013096049A1 (en) | 2013-06-27 |
MX2014007729A (es) | 2015-01-12 |
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