MX2020009517A - Compuestos biciclicos como inhibidores de la interaccion/activacio n de pdl/pd-l1. - Google Patents
Compuestos biciclicos como inhibidores de la interaccion/activacio n de pdl/pd-l1.Info
- Publication number
- MX2020009517A MX2020009517A MX2020009517A MX2020009517A MX2020009517A MX 2020009517 A MX2020009517 A MX 2020009517A MX 2020009517 A MX2020009517 A MX 2020009517A MX 2020009517 A MX2020009517 A MX 2020009517A MX 2020009517 A MX2020009517 A MX 2020009517A
- Authority
- MX
- Mexico
- Prior art keywords
- inhibitors
- activation
- interaction
- bicyclic compounds
- compounds
- Prior art date
Links
- 230000004913 activation Effects 0.000 title abstract 2
- 125000002619 bicyclic group Chemical group 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 230000003993 interaction Effects 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229940002612 prodrug Drugs 0.000 abstract 2
- 239000000651 prodrug Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- 102000008096 B7-H1 Antigen Human genes 0.000 abstract 1
- 108010074708 B7-H1 Antigen Proteins 0.000 abstract 1
Classifications
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
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- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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- C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
Abstract
Los compuestos de Fórmula I se describe en el presente documento junto con sus polimorfos, estereoisómeros, tautómeros, profármacos, solvatos y sales farmacéuticamente aceptables de los mismos. Los compuestos que se describen en el presente documento, sus polimorfos, estereoisómeros, tautómeros, profármacos, solvatos y sales farmacéuticamente aceptables de los mismos son compuestos bicíclicos que son inhibidores de la interacción/activación de PD-1/PD-L1. (Ver Fórmula I).
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IN201841009252 | 2018-03-13 | ||
PCT/IN2019/050203 WO2019175897A1 (en) | 2018-03-13 | 2019-03-13 | Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation |
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MX2020009517A MX2020009517A (es) | 2018-03-13 | 2019-03-13 | Compuestos biciclicos como inhibidores de la interaccion/activacio n de pdl/pd-l1. |
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US (1) | US11529341B2 (es) |
EP (1) | EP3765453A1 (es) |
JP (1) | JP7279063B6 (es) |
KR (1) | KR20200131845A (es) |
CN (1) | CN112105610B (es) |
AU (1) | AU2019234185A1 (es) |
BR (1) | BR112020018610A2 (es) |
CA (1) | CA3093527A1 (es) |
IL (1) | IL277183B2 (es) |
MX (1) | MX2020009517A (es) |
SG (1) | SG11202008950PA (es) |
WO (1) | WO2019175897A1 (es) |
ZA (1) | ZA202005666B (es) |
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2019
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- 2019-03-13 EP EP19714491.8A patent/EP3765453A1/en active Pending
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- 2019-03-13 CA CA3093527A patent/CA3093527A1/en active Pending
- 2019-03-13 JP JP2020548947A patent/JP7279063B6/ja active Active
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JP7279063B2 (ja) | 2023-05-22 |
CN112105610B (zh) | 2024-01-26 |
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WO2019175897A1 (en) | 2019-09-19 |
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ZA202005666B (en) | 2021-09-29 |
RU2020132944A (ru) | 2022-04-14 |
BR112020018610A2 (pt) | 2020-12-29 |
CN112105610A (zh) | 2020-12-18 |
SG11202008950PA (en) | 2020-10-29 |
KR20200131845A (ko) | 2020-11-24 |
EP3765453A1 (en) | 2021-01-20 |
AU2019234185A1 (en) | 2020-10-01 |
IL277183B1 (en) | 2023-04-01 |
RU2020132944A3 (es) | 2022-04-14 |
JP7279063B6 (ja) | 2024-02-15 |
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