GB1356789A - Derivatives of theophylline - Google Patents

Derivatives of theophylline

Info

Publication number
GB1356789A
GB1356789A GB3802570A GB3802570A GB1356789A GB 1356789 A GB1356789 A GB 1356789A GB 3802570 A GB3802570 A GB 3802570A GB 3802570 A GB3802570 A GB 3802570A GB 1356789 A GB1356789 A GB 1356789A
Authority
GB
United Kingdom
Prior art keywords
formula
theophylline
pyridine
reacting
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3802570A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Prodotti Antibiotici SpA
Original Assignee
Prodotti Antibiotici SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prodotti Antibiotici SpA filed Critical Prodotti Antibiotici SpA
Priority to GB3802570A priority Critical patent/GB1356789A/en
Priority to ES393934A priority patent/ES393934A2/en
Priority to FR7128797A priority patent/FR2102082B2/fr
Priority to BE771009A priority patent/BE771009R/en
Publication of GB1356789A publication Critical patent/GB1356789A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1356789 Theophylline derivatives SPASOC PRODOTTI ANTIBIOTICI SpA 3 Aug 1971 [6 Aug 1970] 38025/70 Addition to 1230663 Heading C2C Novel theophylline derivatives of the general Formula (II) wherein R 1 is H, or pyridine-carbonyl, R 2 is H, pyridine-carbonyl, pyridine-carbonyloxy or alkylol, at least one of R 1 and R 2 being other than H, and R 3 is alkyl, and the acid addition and quaternary ammonium compounds thereof, may be obtained (a) by reacting a compound of Formula (IV) wherein R 4 is H or an alkylol radical, with a pyridine carboxylic acid or its reactive derivative, (b) by reaction of theophylline with a compound of the formula in which " halogen " is Br, Cl or I, in the presence of an inert solvent, or (c) by reacting a 7- (#-halohydroxyalkyl)-theophylline of the Formula (VI) in which halogen is Cl, Br or I, with an amine R 2 NHR 3 , in the presence of an inert solvent; and optionally reacting the product with an organic or inorganic acid to form the acid addition salt, or with a quaternizing agent to form the quaternary ammonium compound. Pharmaceutical compositions having diuretic, bronchiolar dilating, myocardial stimulating, smooth muscle relaxing, lipotropic, analeptic and vasodilating activity comprise compounds of Formula (II) above in admixture with a liquid or solid pharmaceutical diluent or carrier, in forms suitably for administration orally, intramuscularly, intravenously or rectally.
GB3802570A 1970-08-06 1970-08-06 Derivatives of theophylline Expired GB1356789A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
GB3802570A GB1356789A (en) 1970-08-06 1970-08-06 Derivatives of theophylline
ES393934A ES393934A2 (en) 1970-08-06 1971-08-05 Derivatives of theophylline
FR7128797A FR2102082B2 (en) 1970-08-06 1971-08-05
BE771009A BE771009R (en) 1970-08-06 1971-08-05 DERIVATIVES OF

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3802570A GB1356789A (en) 1970-08-06 1970-08-06 Derivatives of theophylline

Publications (1)

Publication Number Publication Date
GB1356789A true GB1356789A (en) 1974-06-12

Family

ID=10400674

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3802570A Expired GB1356789A (en) 1970-08-06 1970-08-06 Derivatives of theophylline

Country Status (4)

Country Link
BE (1) BE771009R (en)
ES (1) ES393934A2 (en)
FR (1) FR2102082B2 (en)
GB (1) GB1356789A (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5641783A (en) * 1993-11-12 1997-06-24 Cell Therapeutics, Inc. Substituted amino alcohol compounds
US5801181A (en) * 1993-03-31 1998-09-01 Cell Therapeutics, Inc. Amino alcohol substituted cyclic compounds
US11426412B2 (en) 2017-10-18 2022-08-30 Jubilant Epipad LLC Imidazo-pyridine compounds as PAD inhibitors
US11459338B2 (en) 2017-11-24 2022-10-04 Jubilant Episcribe Llc Heterocyclic compounds as PRMT5 inhibitors
US11529341B2 (en) 2018-03-13 2022-12-20 Jubilant Prodel LLC Bicyclic compounds as inhibitors of PD1/PD-L1 interaction/activation
US11629135B2 (en) 2017-11-06 2023-04-18 Jubilant Prodell Llc Pyrimidine derivatives as inhibitors of PD1/PD-L1 activation
US11833156B2 (en) 2017-09-22 2023-12-05 Jubilant Epipad LLC Heterocyclic compounds as pad inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1230663A (en) * 1968-12-10 1971-05-05

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750575A (en) * 1993-03-31 1998-05-12 Cell Therapeutics, Inc. Substituted amino alcohol compounds
US5777117A (en) * 1993-03-31 1998-07-07 Cell Therapeutics, Inc. Method for preparing substituted amino alcohol compounds
US5801181A (en) * 1993-03-31 1998-09-01 Cell Therapeutics, Inc. Amino alcohol substituted cyclic compounds
US5824677A (en) * 1993-03-31 1998-10-20 Cell Therapeutics, Inc. Substituted amino alcohol compounds
US5837703A (en) * 1993-03-31 1998-11-17 Cell Therapeutics, Inc. Amino-alcohol substituted cyclic compounds
US5641783A (en) * 1993-11-12 1997-06-24 Cell Therapeutics, Inc. Substituted amino alcohol compounds
US11833156B2 (en) 2017-09-22 2023-12-05 Jubilant Epipad LLC Heterocyclic compounds as pad inhibitors
US11426412B2 (en) 2017-10-18 2022-08-30 Jubilant Epipad LLC Imidazo-pyridine compounds as PAD inhibitors
US11629135B2 (en) 2017-11-06 2023-04-18 Jubilant Prodell Llc Pyrimidine derivatives as inhibitors of PD1/PD-L1 activation
US11459338B2 (en) 2017-11-24 2022-10-04 Jubilant Episcribe Llc Heterocyclic compounds as PRMT5 inhibitors
US11529341B2 (en) 2018-03-13 2022-12-20 Jubilant Prodel LLC Bicyclic compounds as inhibitors of PD1/PD-L1 interaction/activation

Also Published As

Publication number Publication date
FR2102082B2 (en) 1974-10-18
BE771009R (en) 1971-12-16
FR2102082A2 (en) 1972-04-07
ES393934A2 (en) 1974-02-16

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee