BR112015023060A2 - entidades químicas - Google Patents

entidades químicas

Info

Publication number
BR112015023060A2
BR112015023060A2 BR112015023060A BR112015023060A BR112015023060A2 BR 112015023060 A2 BR112015023060 A2 BR 112015023060A2 BR 112015023060 A BR112015023060 A BR 112015023060A BR 112015023060 A BR112015023060 A BR 112015023060A BR 112015023060 A2 BR112015023060 A2 BR 112015023060A2
Authority
BR
Brazil
Prior art keywords
chemical entities
compositions
treatment
œchemical
entitiesâ
Prior art date
Application number
BR112015023060A
Other languages
English (en)
Other versions
BR112015023060B1 (pt
Inventor
Joaquín Lopez Contreras Andrés
Blanco Aparicio Carmen
Varela Busto Carmen
Álvaro Cebrían Muñoz David
Pastor Fernández Joaquín
Ignacio TOLEDO LÁZARO Luis
NIETO SOLER María
del Rosario RICO FERREIRA María
Murga Costa Matilde
Renner Oliver
Fernández-Capetillo Ruiz Oscar
Martínez González Sonia
RODRÍGUEZ ARÍSTEGUÍ Sonsoles
Original Assignee
Fundacion Centro Nac De Investigaciones Oncologicas Carlos Iii
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48013903&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112015023060(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Fundacion Centro Nac De Investigaciones Oncologicas Carlos Iii filed Critical Fundacion Centro Nac De Investigaciones Oncologicas Carlos Iii
Publication of BR112015023060A2 publication Critical patent/BR112015023060A2/pt
Publication of BR112015023060B1 publication Critical patent/BR112015023060B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Steroid Compounds (AREA)

Abstract

resumo da patente de invenã§ã£o para: “entidades quãmicas”. sã£o fornecidas entidades quã­micas selecionadas a partir de compostos de fã³rmula (i), em que r1, r2 e m tãªm os significados indicados na descriã§ã£o, e os sais, solvatos e estereoisã´meros farmaceuticamente aceitã¡veis dos mesmos, que sã£o inibidores de atr e sã£o potencialmente ãºteis no tratamento de cã¢ncer. sã£o ainda proporcionadas composiã§ãµes farmacãªuticas das entidades quã­micas, produtos de combinaã§ã£o que contãªm as entidades quã­micas, uso das composiã§ãµes como agentes terapãªuticos, e mã©todos de tratamento utilizando essas composiã§ãµes.
BR112015023060-1A 2013-03-15 2014-03-14 Entidades químicas BR112015023060B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13382089 2013-03-15
EP13382089.4 2013-03-15
PCT/GB2014/050825 WO2014140644A1 (en) 2013-03-15 2014-03-14 Chemical entities

Publications (2)

Publication Number Publication Date
BR112015023060A2 true BR112015023060A2 (pt) 2017-07-18
BR112015023060B1 BR112015023060B1 (pt) 2022-07-05

Family

ID=48013903

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015023060-1A BR112015023060B1 (pt) 2013-03-15 2014-03-14 Entidades químicas

Country Status (32)

Country Link
US (1) US9453031B2 (pt)
EP (1) EP2970332B1 (pt)
JP (1) JP6379115B2 (pt)
KR (1) KR102206318B1 (pt)
CN (1) CN105051047B (pt)
AR (1) AR095443A1 (pt)
AU (1) AU2014229735B2 (pt)
BR (1) BR112015023060B1 (pt)
CA (1) CA2904768C (pt)
CL (1) CL2015002591A1 (pt)
CY (1) CY1120619T1 (pt)
DK (1) DK2970332T3 (pt)
EA (1) EA029771B1 (pt)
ES (1) ES2670674T3 (pt)
HK (1) HK1215021A1 (pt)
HR (1) HRP20180839T1 (pt)
HU (1) HUE037685T2 (pt)
IL (1) IL240708B (pt)
LT (1) LT2970332T (pt)
MX (1) MX368056B (pt)
NO (1) NO2970332T3 (pt)
NZ (1) NZ711038A (pt)
PE (1) PE20152007A1 (pt)
PH (1) PH12015502159B1 (pt)
PL (1) PL2970332T3 (pt)
PT (1) PT2970332T (pt)
RS (1) RS57216B1 (pt)
SG (1) SG11201507555PA (pt)
SI (1) SI2970332T1 (pt)
TW (1) TWI557131B (pt)
UA (1) UA118261C2 (pt)
WO (1) WO2014140644A1 (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2649156T3 (es) 2013-01-14 2018-01-10 Incyte Holdings Corporation Compuestos bicíclicos de carboxamida aromática útiles como inhibidores de quinasas Pim
BR112015016793B1 (pt) 2013-01-15 2021-12-28 Incyte Holdings Corporation Compostos de tiazolacarboxamidas e piridinacarboxamida, composição compreendendo os mesmos, método de inibição da enzima pim1, pim2, ou pim3, e usos dos referidos compostos
US9556197B2 (en) 2013-08-23 2017-01-31 Incyte Corporation Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors
US9580418B2 (en) 2014-07-14 2017-02-28 Incyte Corporation Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
US9822124B2 (en) 2014-07-14 2017-11-21 Incyte Corporation Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors
WO2016112374A2 (en) * 2015-01-09 2016-07-14 The General Hospital Corporation Treating cancer using inhibitors of ataxia-telangiectasia mutated and rad3-related (atr)
US9540347B2 (en) 2015-05-29 2017-01-10 Incyte Corporation Pyridineamine compounds useful as Pim kinase inhibitors
AR105967A1 (es) 2015-09-09 2017-11-29 Incyte Corp Sales de un inhibidor de pim quinasa
WO2017059251A1 (en) 2015-10-02 2017-04-06 Incyte Corporation Heterocyclic compounds useful as pim kinase inhibitors
CN109071565B (zh) * 2016-05-24 2022-05-10 默克专利股份公司 三环杂环衍生物
TW201924683A (zh) 2017-12-08 2019-07-01 美商英塞特公司 用於治療骨髓增生性贅瘤的低劑量組合療法
AU2019217388C1 (en) * 2018-02-07 2024-03-07 Wuxi Biocity Biopharmaceutics Co., Ltd. ATR inhibitor and application thereof
WO2020094084A1 (zh) * 2018-11-07 2020-05-14 南京明德新药研发有限公司 作为ret抑制剂的三并环衍生物
CN113004303A (zh) * 2019-12-18 2021-06-22 江苏恒瑞医药股份有限公司 嘧啶并噁嗪类三环衍生物、其制备方法及其在医药上的应用
WO2021143821A1 (zh) * 2020-01-17 2021-07-22 江苏恒瑞医药股份有限公司 稠合杂芳基类衍生物、其制备方法及其在医药上的应用
JP2023545196A (ja) 2020-10-16 2023-10-26 シャンハイ ドーァ ノボ ファーマテック カンパニー，リミティド 三複素環誘導体、その医薬組成物及び使用
CN115466258A (zh) * 2021-06-11 2022-12-13 成都苑东生物制药股份有限公司 Atr抑制剂及其用途
CN115286645A (zh) * 2022-08-16 2022-11-04 南京雷正医药科技有限公司 三环杂环衍生物及其药物组合物和用途

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5583024A (en) 1985-12-02 1996-12-10 The Regents Of The University Of California Recombinant expression of Coleoptera luciferase
WO1993014080A1 (en) * 1992-01-15 1993-07-22 E.I. Du Pont De Nemours And Company Bridged heterocyclic fungicides
JPH08336393A (ja) 1995-04-13 1996-12-24 Mitsubishi Chem Corp 光学活性なγ−置換−β−ヒドロキシ酪酸エステルの製造法
US20020192228A1 (en) 1997-02-12 2002-12-19 Samir M. Hanash Protein markers for lung cancer and use thereof
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
US6602677B1 (en) 1997-09-19 2003-08-05 Promega Corporation Thermostable luciferases and methods of production
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
GB9900752D0 (en) 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
PL199802B1 (pl) 1999-02-10 2008-10-31 Astrazeneca Ab Pochodne chinazoliny, sposoby ich wytwarzania, ich kompozycje farmaceutyczne i ich zastosowania
EP1676845B1 (en) 1999-11-05 2008-06-11 AstraZeneca AB New quinazoline derivatives
ES2290117T3 (es) 2000-02-15 2008-02-16 Sugen, Inc. Inhibidores de proteina quinasa 2-indolina sustituida con pirrol.
IL152682A0 (en) 2000-05-31 2003-06-24 Astrazeneca Ab Indole derivatives with vascular damaging activity
UA73993C2 (uk) 2000-06-06 2005-10-17 Астразенека Аб Хіназолінові похідні для лікування пухлин та фармацевтична композиція
KR20030022264A (ko) 2000-07-07 2003-03-15 앤지오젠 파마슈티칼스 리미티드 신생 혈관 형성 억제제인 콜치놀 유도체
US20050277627A1 (en) 2000-07-07 2005-12-15 Arnould Jean C Colchinol derivatives as vascular damaging agents
US8735411B2 (en) * 2006-10-02 2014-05-27 Abbvie Inc. Macrocyclic benzofused pyrimidine derivatives
KR20090085591A (ko) * 2006-10-30 2009-08-07 노파르티스 아게 Ｐｉ3ｋ 지질 키나제 억제제로서의 이미다조피리다진
PE20090215A1 (es) * 2007-05-09 2009-03-30 Novartis Ag Compuestos derivados de imidazopiridazinas como inhibidores de cinasa
JP5746172B2 (ja) * 2009-08-20 2015-07-08 カルス セラピューティクス リミテッド ホスホイノシチド３−キナーゼ阻害剤としての三環式複素環化合物
CN102020657A (zh) * 2009-09-11 2011-04-20 上海艾力斯医药科技有限公司 稠合杂芳基衍生物、制备方法及其应用
CA2803802A1 (en) * 2010-06-23 2011-12-29 Vertex Pharmaceuticals Incorporated Pyrrolo- pyrazine derivatives useful as inhibitors of atr kinase
BR112013014914B8 (pt) 2010-12-16 2020-08-04 Hoffmann La Roche composto, composição farmacêutica e uso de um composto

Also Published As

Publication number Publication date
US9453031B2 (en) 2016-09-27
PH12015502159A1 (en) 2016-01-25
BR112015023060B1 (pt) 2022-07-05
PL2970332T3 (pl) 2018-08-31
UA118261C2 (uk) 2018-12-26
MX2015011549A (es) 2016-05-31
WO2014140644A1 (en) 2014-09-18
EP2970332A1 (en) 2016-01-20
CL2015002591A1 (es) 2016-02-05
KR102206318B1 (ko) 2021-01-25
NO2970332T3 (pt) 2018-07-28
CA2904768A1 (en) 2014-09-18
EA201591781A1 (ru) 2016-02-29
SG11201507555PA (en) 2015-10-29
AR095443A1 (es) 2015-10-14
EA029771B1 (ru) 2018-05-31
TWI557131B (zh) 2016-11-11
PT2970332T (pt) 2018-05-25
RS57216B1 (sr) 2018-07-31
HUE037685T2 (hu) 2018-09-28
ES2670674T3 (es) 2018-05-31
CY1120619T1 (el) 2019-12-11
IL240708B (en) 2019-08-29
AU2014229735B2 (en) 2018-08-09
LT2970332T (lt) 2018-06-11
CA2904768C (en) 2021-07-27
KR20150129741A (ko) 2015-11-20
IL240708A0 (en) 2015-10-29
CN105051047B (zh) 2017-12-15
EP2970332B1 (en) 2018-02-28
CN105051047A (zh) 2015-11-11
JP2016510803A (ja) 2016-04-11
DK2970332T3 (en) 2018-05-22
NZ711038A (en) 2020-02-28
MX368056B (es) 2019-09-18
HRP20180839T1 (hr) 2018-06-29
AU2014229735A1 (en) 2015-09-03
US20160024112A1 (en) 2016-01-28
TW201446772A (zh) 2014-12-16
JP6379115B2 (ja) 2018-08-22
HK1215021A1 (zh) 2016-08-12
SI2970332T1 (en) 2018-06-29
PE20152007A1 (es) 2016-02-04
PH12015502159B1 (en) 2016-01-25

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 14/03/2014, OBSERVADAS AS CONDICOES LEGAIS