CL2015002591A1 - Entidades químicas. - Google Patents

Entidades químicas.

Info

Publication number
CL2015002591A1
CL2015002591A1 CL2015002591A CL2015002591A CL2015002591A1 CL 2015002591 A1 CL2015002591 A1 CL 2015002591A1 CL 2015002591 A CL2015002591 A CL 2015002591A CL 2015002591 A CL2015002591 A CL 2015002591A CL 2015002591 A1 CL2015002591 A1 CL 2015002591A1
Authority
CL
Chile
Prior art keywords
chemical entities
cancer
oxazepina
oxazina
pirimido
Prior art date
Application number
CL2015002591A
Other languages
English (en)
Inventor
Fernandez Joaquín Pastor
Ruiz Oscar Fernandez-Capetillo
González Sonia Martínez
Aparicio Carmen Blanco
Ferreria Maria Del Rosario Rico
Lázaro Luis Ignacio Toledo
Arísteguí Sonsoles Rodríguez
Costa Matilde Murga
Busto Carmen Varela
Contreras Andrés Joaquín Lopez
Oliver Renner
Soler Maria Nieto
Muñoz David Alvaro Cebrian
Original Assignee
Fundación Ct Nac De Investigaciones Oncológicas Carlos Iii
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48013903&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2015002591(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Fundación Ct Nac De Investigaciones Oncológicas Carlos Iii filed Critical Fundación Ct Nac De Investigaciones Oncológicas Carlos Iii
Publication of CL2015002591A1 publication Critical patent/CL2015002591A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Steroid Compounds (AREA)

Abstract

COMPUESTOS DERIVADOS DE [1,4]OXAZINO[4,3-D]PIRIMIDO[5,4-B][1,4]OXAZINA/OXAZEPINA, INHIBIDORES DE ATR; COMPOSICION FARMACEUTICA; COMBINACION FARMACEUTICA; Y SU USO PARA EL TRATAMIENTO ASOCIADA A UNA PROLIFERACION AUMENTADA, COMO CANCER, TAL COMO CANCER DE ENDOMETRIO, COLON O ESTOMAGO
CL2015002591A 2013-03-15 2015-09-10 Entidades químicas. CL2015002591A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP13382089 2013-03-15

Publications (1)

Publication Number Publication Date
CL2015002591A1 true CL2015002591A1 (es) 2016-02-05

Family

ID=48013903

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2015002591A CL2015002591A1 (es) 2013-03-15 2015-09-10 Entidades químicas.

Country Status (32)

Country Link
US (1) US9453031B2 (es)
EP (1) EP2970332B1 (es)
JP (1) JP6379115B2 (es)
KR (1) KR102206318B1 (es)
CN (1) CN105051047B (es)
AR (1) AR095443A1 (es)
AU (1) AU2014229735B2 (es)
BR (1) BR112015023060B1 (es)
CA (1) CA2904768C (es)
CL (1) CL2015002591A1 (es)
CY (1) CY1120619T1 (es)
DK (1) DK2970332T3 (es)
EA (1) EA029771B1 (es)
ES (1) ES2670674T3 (es)
HK (1) HK1215021A1 (es)
HR (1) HRP20180839T1 (es)
HU (1) HUE037685T2 (es)
IL (1) IL240708B (es)
LT (1) LT2970332T (es)
MX (1) MX368056B (es)
NO (1) NO2970332T3 (es)
NZ (1) NZ711038A (es)
PE (1) PE20152007A1 (es)
PH (1) PH12015502159B1 (es)
PL (1) PL2970332T3 (es)
PT (1) PT2970332T (es)
RS (1) RS57216B1 (es)
SG (1) SG11201507555PA (es)
SI (1) SI2970332T1 (es)
TW (1) TWI557131B (es)
UA (1) UA118261C2 (es)
WO (1) WO2014140644A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6437452B2 (ja) 2013-01-14 2018-12-12 インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ Ｐｉｍキナーゼ阻害剤として有用な二環式芳香族カルボキサミド化合物
KR102403306B1 (ko) 2013-01-15 2022-06-02 인사이트 홀딩스 코포레이션 Pim 키나제 저해제로서 유용한 티아졸카복스아마이드 및 피리딘카복스아마이드 화합물
JP2016528298A (ja) 2013-08-23 2016-09-15 インサイト・コーポレイションＩｎｃｙｔｅ Ｃｏｒｐｏｒａｔｉｏｎ Ｐｉｍキナーゼ阻害剤として有用なフロピリジン及びチエノピリジンカルボキシアミド化合物
WO2016010897A1 (en) 2014-07-14 2016-01-21 Incyte Corporation Bicyclic heteroaromatic carboxamide compounds useful as pim kinase inhibitors
US9580418B2 (en) 2014-07-14 2017-02-28 Incyte Corporation Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
WO2016112374A2 (en) * 2015-01-09 2016-07-14 The General Hospital Corporation Treating cancer using inhibitors of ataxia-telangiectasia mutated and rad3-related (atr)
WO2016196244A1 (en) 2015-05-29 2016-12-08 Incyte Corporation Pyridineamine compounds useful as pim kinase inhibitors
TWI734699B (zh) 2015-09-09 2021-08-01 美商英塞特公司 Ｐｉｍ激酶抑制劑之鹽
WO2017059251A1 (en) 2015-10-02 2017-04-06 Incyte Corporation Heterocyclic compounds useful as pim kinase inhibitors
WO2017202748A1 (en) * 2016-05-24 2017-11-30 Merck Patent Gmbh Tricyclic heterocylic derivatives
AR113922A1 (es) 2017-12-08 2020-07-01 Incyte Corp Terapia de combinación de dosis baja para el tratamiento de neoplasias mieloproliferativas
BR112020016020A8 (pt) * 2018-02-07 2023-04-25 Shijiazhuang Sagacity New Drug Dev Company Ltd Inibidor de atr e aplicação do mesmo
WO2020094084A1 (zh) * 2018-11-07 2020-05-14 南京明德新药研发有限公司 作为ret抑制剂的三并环衍生物
CN113004303A (zh) * 2019-12-18 2021-06-22 江苏恒瑞医药股份有限公司 嘧啶并噁嗪类三环衍生物、其制备方法及其在医药上的应用
WO2021143821A1 (zh) * 2020-01-17 2021-07-22 江苏恒瑞医药股份有限公司 稠合杂芳基类衍生物、其制备方法及其在医药上的应用
CN114369096A (zh) 2020-10-16 2022-04-19 上海迪诺医药科技有限公司 三杂环衍生物、其药物组合物及应用
CN115466258A (zh) * 2021-06-11 2022-12-13 成都苑东生物制药股份有限公司 Atr抑制剂及其用途
CN115286645A (zh) * 2022-08-16 2022-11-04 南京雷正医药科技有限公司 三环杂环衍生物及其药物组合物和用途

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5583024A (en) 1985-12-02 1996-12-10 The Regents Of The University Of California Recombinant expression of Coleoptera luciferase
WO1993014080A1 (en) * 1992-01-15 1993-07-22 E.I. Du Pont De Nemours And Company Bridged heterocyclic fungicides
JPH08336393A (ja) 1995-04-13 1996-12-24 Mitsubishi Chem Corp 光学活性なγ−置換−β−ヒドロキシ酪酸エステルの製造法
WO1998035985A1 (en) 1997-02-12 1998-08-20 The Regents Of The University Of Michigan Protein markers for lung cancer and use thereof
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
US6602677B1 (en) 1997-09-19 2003-08-05 Promega Corporation Thermostable luciferases and methods of production
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
GB9900752D0 (en) 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
AU763618B2 (en) 1999-02-10 2003-07-31 Astrazeneca Ab Quinazoline derivatives as angiogenesis inhibitors
PT1244647E (pt) 1999-11-05 2006-10-31 Astrazeneca Ab Derivados de quinazolina como inibidores de vegf
DE122010000004I1 (de) 2000-02-15 2010-04-15 Sugen Inc Pyrrol substituierte indolin-2-on protein kinase inhibitoren
JP2003535078A (ja) 2000-05-31 2003-11-25 アストラゼネカ アクチボラグ 血管損傷活性のあるインドール誘導体
UA73993C2 (uk) 2000-06-06 2005-10-17 Астразенека Аб Хіназолінові похідні для лікування пухлин та фармацевтична композиція
BR0112224A (pt) 2000-07-07 2003-06-10 Angiogene Pharm Ltd Composto, composição farmacêutica, uso de um composto ou de um sal, solvato ou pró-droga farmaceuticamente aceitável do mesmo, e, processo para preparar um composto
WO2002008213A1 (en) 2000-07-07 2002-01-31 Angiogene Pharmaceuticals Limited Colchinol derivatives as angiogenesis inhibitors
US8735411B2 (en) * 2006-10-02 2014-05-27 Abbvie Inc. Macrocyclic benzofused pyrimidine derivatives
WO2008052733A1 (en) * 2006-10-30 2008-05-08 Novartis Ag Imidazopyridazines as pi3k lipid kinase inhibitors
EA200901488A1 (ru) * 2007-05-09 2010-04-30 Новартис Аг Замещенные имидазолопиридазины, как ингибиторы липидкиназы
AU2010286168B2 (en) * 2009-08-20 2014-05-15 Karus Therapeutics Limited Tricyclic heterocyclic compounds as phosphoinositide 3-kinase inhibitors
CN102020657A (zh) * 2009-09-11 2011-04-20 上海艾力斯医药科技有限公司 稠合杂芳基衍生物、制备方法及其应用
JP2013529643A (ja) * 2010-06-23 2013-07-22 バーテックス ファーマシューティカルズ インコーポレイテッド Ａｔｒキナーゼ阻害剤として有用なピロロピラジン誘導体
CA2820078C (en) * 2010-12-16 2019-02-12 F. Hoffmann-La Roche Ag Tricyclic pi3k inhibitor compounds and methods of use

Also Published As

Publication number Publication date
CA2904768C (en) 2021-07-27
UA118261C2 (uk) 2018-12-26
EP2970332B1 (en) 2018-02-28
EA029771B1 (ru) 2018-05-31
NO2970332T3 (es) 2018-07-28
IL240708A0 (en) 2015-10-29
EP2970332A1 (en) 2016-01-20
PH12015502159A1 (en) 2016-01-25
AR095443A1 (es) 2015-10-14
HRP20180839T1 (hr) 2018-06-29
PE20152007A1 (es) 2016-02-04
TWI557131B (zh) 2016-11-11
CN105051047B (zh) 2017-12-15
CA2904768A1 (en) 2014-09-18
KR102206318B1 (ko) 2021-01-25
JP2016510803A (ja) 2016-04-11
PL2970332T3 (pl) 2018-08-31
BR112015023060A2 (pt) 2017-07-18
NZ711038A (en) 2020-02-28
BR112015023060B1 (pt) 2022-07-05
AU2014229735A1 (en) 2015-09-03
EA201591781A1 (ru) 2016-02-29
AU2014229735B2 (en) 2018-08-09
MX368056B (es) 2019-09-18
MX2015011549A (es) 2016-05-31
PH12015502159B1 (en) 2016-01-25
JP6379115B2 (ja) 2018-08-22
CY1120619T1 (el) 2019-12-11
KR20150129741A (ko) 2015-11-20
DK2970332T3 (en) 2018-05-22
HK1215021A1 (zh) 2016-08-12
TW201446772A (zh) 2014-12-16
SG11201507555PA (en) 2015-10-29
US20160024112A1 (en) 2016-01-28
RS57216B1 (sr) 2018-07-31
CN105051047A (zh) 2015-11-11
ES2670674T3 (es) 2018-05-31
PT2970332T (pt) 2018-05-25
SI2970332T1 (en) 2018-06-29
LT2970332T (lt) 2018-06-11
HUE037685T2 (hu) 2018-09-28
IL240708B (en) 2019-08-29
US9453031B2 (en) 2016-09-27
WO2014140644A1 (en) 2014-09-18

Similar Documents

Publication Publication Date Title
CL2015002591A1 (es) Entidades químicas.
CL2021000008A1 (es) Uso de un heparinoide para el tratamiento del cáncer (divisional de la solicitud n° 201403017)
CL2014002873A1 (es) Compuestos derivados de pirimidin-amina o triazin-amina, inhibidores de adn-pk; composicion farmaceutica; y su uso para el tratamiento del cancer.
CL2016002735A1 (es) Compuestos de imidazo[4,5-c]quinolin-2-ona y su uso para tratar cáncer
CL2015003491A1 (es) Compuestos químicos.
CL2015001985A1 (es) Compuestos de tiazolcarboxamidas y piridinacarboxamida, inhibidores de quinasa pim.
CL2016002027A1 (es) Ciclopropilamina como inhibidor de la lsd1
CL2016001231A1 (es) Compuestos de inhibidor de autotaxina
CL2016000922A1 (es) Derivados de anillo bicíclico fusionado piridilo como inhibidores fgfr4
CL2015002932A1 (es) Inhibidores de proteína quinasa
JO3433B1 (ar) حلقة كاربوكسامايد ذات أربع أعضاء للاستخدام كمبيدات النيماتودا
UY34657A (es) ?derivados macrocíclicos para el tratamiento de enfermedades?.
CL2015003089A1 (es) Heterociclos biciclicos como inhibidores de fgfr.
CL2012003415A1 (es) Compuestos derivados de 2-oxo-piperidina y 1,1-dioxido-tiazina, inhibidores de mdm2; composicion farmaceutica que los comprende; y su uso para el tratamiento del cancer .
EP4230264A3 (en) Prodrugs of fumarates and their use in treating various deseases
CL2013002898A1 (es) Compuestos derivados de benceno sustituido con arilo o heteroarilo; composicion farmaceutica que los comprende y uso en el tratamiento del cancer.
CL2014001858A1 (es) Compuestos derivados de pirrolidina-2-carboxamidas sustituidas, antagonistas de mdm2; composicion farmacetica; y su uso en el tratamiento o profilaxis del cancer.
CL2015001377A1 (es) Inhbibidores de bmi-1 primidinas sustituidas inversas
UY34566A (es) 1,4?dihidropirimidinas 4,4?disustituidas y su uso como medicamentos para el tratamiento de la hepatitis b
CL2013000016A1 (es) Compuestos derivados de imidazopiridina; procedimiento de preparacion; composicion farmaceutica y su uso en el tratamiento del cancer.
EA201171367A1 (ru) Винилиндазолильные соединения
UY36075A (es) Derivados de tubulisina
MX2015014298A (es) Compuestos de dihidropirido pirimidina como inhibidores de autotaxina.
EA201400178A1 (ru) Лечение рака молочной железы
CL2015002897A1 (es) Inhibidores de bace1