CN118879746A - 用于改变基因产物的表达的crispr-cas系统和方法 - Google Patents

用于改变基因产物的表达的crispr-cas系统和方法 Download PDF

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Publication number
CN118879746A
CN118879746A CN202410963686.8A CN202410963686A CN118879746A CN 118879746 A CN118879746 A CN 118879746A CN 202410963686 A CN202410963686 A CN 202410963686A CN 118879746 A CN118879746 A CN 118879746A
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Prior art keywords
crispr
sequence
cas system
guide
cas9 protein
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Pending
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CN202410963686.8A
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Chinese (zh)
Inventor
F·张
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Massachusetts Institute of Technology
Broad Institute Inc
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Massachusetts Institute of Technology
Broad Institute Inc
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Application filed by Massachusetts Institute of Technology, Broad Institute Inc filed Critical Massachusetts Institute of Technology
Publication of CN118879746A publication Critical patent/CN118879746A/zh
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    • C12N9/222—Clustered regularly interspaced short palindromic repeats [CRISPR]-associated [CAS] enzymes
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CN202410963686.8A 2012-12-12 2013-12-12 用于改变基因产物的表达的crispr-cas系统和方法 Pending CN118879746A (zh)

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US201261736527P 2012-12-12 2012-12-12
US61/736,527 2012-12-12
US201361748427P 2013-01-02 2013-01-02
US61/748,427 2013-01-02
US201361791409P 2013-03-15 2013-03-15
US61/791,409 2013-03-15
US201361835931P 2013-06-17 2013-06-17
US61/835,931 2013-06-17
US201361842322P 2013-07-02 2013-07-02
US61/842,322 2013-07-02
US14/054,414 2013-10-15
US14/054,414 US8697359B1 (en) 2012-12-12 2013-10-15 CRISPR-Cas systems and methods for altering expression of gene products
PCT/US2013/074743 WO2014093661A2 (en) 2012-12-12 2013-12-12 Crispr-cas systems and methods for altering expression of gene products
CN201380072715.1A CN106170549B (zh) 2012-12-12 2013-12-12 用于改变基因产物的表达的crispr-cas系统和方法

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CN118879746A true CN118879746A (zh) 2024-11-01

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CN202410963686.8A Pending CN118879746A (zh) 2012-12-12 2013-12-12 用于改变基因产物的表达的crispr-cas系统和方法
CN201610902578.5A Active CN106480080B (zh) 2012-12-12 2013-12-12 用于改变基因产物的表达的crispr-cas系统和方法
CN202010072631.XA Active CN111187772B (zh) 2012-12-12 2013-12-12 用于改变基因产物的表达的crispr-cas系统和方法
CN201380072715.1A Active CN106170549B (zh) 2012-12-12 2013-12-12 用于改变基因产物的表达的crispr-cas系统和方法

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CN202010072631.XA Active CN111187772B (zh) 2012-12-12 2013-12-12 用于改变基因产物的表达的crispr-cas系统和方法
CN201380072715.1A Active CN106170549B (zh) 2012-12-12 2013-12-12 用于改变基因产物的表达的crispr-cas系统和方法

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US (8) US8697359B1 (https=)
EP (2) EP2764103B1 (https=)
JP (6) JP6545621B2 (https=)
KR (1) KR20150107739A (https=)
CN (4) CN118879746A (https=)
AU (5) AU2013359238B2 (https=)
BR (1) BR112015013785A2 (https=)
CA (1) CA2894688A1 (https=)
DK (1) DK2764103T3 (https=)
ES (1) ES2552535T3 (https=)
HK (1) HK1216259A1 (https=)
PL (1) PL2764103T3 (https=)
PT (1) PT2764103E (https=)
RU (1) RU2687451C1 (https=)
WO (1) WO2014093661A2 (https=)

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