DK3565891T3 - Fremgangsmåder til ændring af genekspression ved forstyrrelse af transkriptionsfaktor-multimere, der strukturerer regulatoriske sløjfer - Google Patents
Fremgangsmåder til ændring af genekspression ved forstyrrelse af transkriptionsfaktor-multimere, der strukturerer regulatoriske sløjfer Download PDFInfo
- Publication number
- DK3565891T3 DK3565891T3 DK18736585.3T DK18736585T DK3565891T3 DK 3565891 T3 DK3565891 T3 DK 3565891T3 DK 18736585 T DK18736585 T DK 18736585T DK 3565891 T3 DK3565891 T3 DK 3565891T3
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- Prior art keywords
- methods
- gene expression
- transcription factor
- altering gene
- factor multimers
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Links
- 102000040945 Transcription factor Human genes 0.000 title 1
- 108091023040 Transcription factor Proteins 0.000 title 1
- 230000014509 gene expression Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 230000001105 regulatory effect Effects 0.000 title 1
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
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- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- C12N2015/8527—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic for producing animal models, e.g. for tests or diseases
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/51—Physical structure in polymeric form, e.g. multimers, concatemers
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- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
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- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/15—Vector systems having a special element relevant for transcription chimeric enhancer/promoter combination
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- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
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- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Plant Pathology (AREA)
- Toxicology (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762444341P | 2017-01-09 | 2017-01-09 | |
US201762596093P | 2017-12-07 | 2017-12-07 | |
PCT/US2018/013003 WO2018129544A1 (en) | 2017-01-09 | 2018-01-09 | Methods of altering gene expression by perturbing transcription factor multimers that structure regulatory loops |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3565891T3 true DK3565891T3 (da) | 2023-07-24 |
Family
ID=62790999
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK18736585.3T DK3565891T3 (da) | 2017-01-09 | 2018-01-09 | Fremgangsmåder til ændring af genekspression ved forstyrrelse af transkriptionsfaktor-multimere, der strukturerer regulatoriske sløjfer |
Country Status (6)
Country | Link |
---|---|
US (1) | US11873496B2 (da) |
EP (2) | EP4249501A3 (da) |
DK (1) | DK3565891T3 (da) |
ES (1) | ES2949801T3 (da) |
FI (1) | FI3565891T3 (da) |
WO (1) | WO2018129544A1 (da) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2019531763A (ja) | 2016-09-07 | 2019-11-07 | フラッグシップ パイオニアリング, インコーポレイテッド | 遺伝子発現をモジュレートするための方法および組成物 |
DK3565891T3 (da) | 2017-01-09 | 2023-07-24 | Whitehead Inst Biomedical Res | Fremgangsmåder til ændring af genekspression ved forstyrrelse af transkriptionsfaktor-multimere, der strukturerer regulatoriske sløjfer |
KR20210124374A (ko) | 2019-02-08 | 2021-10-14 | 듀포인트 테라퓨틱스, 인크. | 화합물의 응축물-연관된 특징을 특징규명하는 방법 및 그의 용도 |
KR20220084047A (ko) | 2019-09-18 | 2022-06-21 | 듀포인트 테라퓨틱스, 인크. | 응축물 관련 특이성에 대한 스크리닝 방법 및 이의 용도 |
JP2022548399A (ja) | 2019-09-23 | 2022-11-18 | オメガ セラピューティクス, インコーポレイテッド | 肝細胞核因子4-アルファ(HNF4α)遺伝子発現をモジュレートするための組成物および方法 |
EP3967760A1 (en) | 2020-09-11 | 2022-03-16 | Synovance | Methods for engineering chromosomal architecture for gene expression |
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EP4249501A2 (en) | 2023-09-27 |
EP4249501A3 (en) | 2024-01-03 |
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EP3565891A1 (en) | 2019-11-13 |
US20190352648A1 (en) | 2019-11-21 |
ES2949801T3 (es) | 2023-10-03 |
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