BR112018011503A2 - promotores da corynebacterium glutamicum - Google Patents

promotores da corynebacterium glutamicum

Info

Publication number
BR112018011503A2
BR112018011503A2 BR112018011503A BR112018011503A BR112018011503A2 BR 112018011503 A2 BR112018011503 A2 BR 112018011503A2 BR 112018011503 A BR112018011503 A BR 112018011503A BR 112018011503 A BR112018011503 A BR 112018011503A BR 112018011503 A2 BR112018011503 A2 BR 112018011503A2
Authority
BR
Brazil
Prior art keywords
promoters
corynebacterium glutamicum
gene expression
host cells
glutamicum promoters
Prior art date
Application number
BR112018011503A
Other languages
English (en)
Inventor
G Gora Katherine
P Manchester Shawn
Serber Zach
Original Assignee
Zymergen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymergen Inc filed Critical Zymergen Inc
Publication of BR112018011503A2 publication Critical patent/BR112018011503A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine

Abstract

são fornecidos promotores nativos compreendendo polinucleotídeos isolados de corynebacterium glutamicum e promotores mutantes derivados dos mesmos que podem ser utilizados para regular, isto é, ou aumentar ou diminuir expressão gênica. são também fornecidas escadas promotoras compreendendo uma pluralidade de promotores que têm uma atividade promotora incrementalmente crescente. são também fornecidas células hospedeiras e vetores recombinantes compreendendo os promotores e métodos de expressão de genes de interesse e produção de biomoléculas utilizando as células hospedeiras.
BR112018011503A 2015-12-07 2016-12-07 promotores da corynebacterium glutamicum BR112018011503A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562264232P 2015-12-07 2015-12-07
US201662431409P 2016-12-07 2016-12-07
PCT/US2016/065464 WO2017100376A2 (en) 2015-12-07 2016-12-07 Promoters from corynebacterium glutamicum

Publications (1)

Publication Number Publication Date
BR112018011503A2 true BR112018011503A2 (pt) 2018-12-04

Family

ID=57868324

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018011503A BR112018011503A2 (pt) 2015-12-07 2016-12-07 promotores da corynebacterium glutamicum

Country Status (6)

Country Link
US (2) US11293029B2 (pt)
JP (1) JP6821598B2 (pt)
KR (1) KR20180084756A (pt)
BR (1) BR112018011503A2 (pt)
CA (1) CA3007635A1 (pt)
WO (1) WO2017100376A2 (pt)

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WO2022191358A1 (ko) * 2021-03-09 2022-09-15 대상 주식회사 L-라이신 생산능이 향상된 코리네박테리움 글루타미쿰 변이주 및 이를 이용한 l-라이신의 생산 방법
CN112695036B (zh) * 2021-03-23 2021-07-06 中国科学院天津工业生物技术研究所 一种天冬氨酸激酶基因表达调控序列及其应用
CN115449519B (zh) * 2021-06-08 2023-04-07 中国科学院天津工业生物技术研究所 基于dapB基因的具有启动子活性的多核苷酸及其用途
WO2022265130A1 (ko) * 2021-06-15 2022-12-22 씨제이제일제당 (주) 신규 프로모터 및 이의 용도
CN116536310A (zh) * 2022-01-26 2023-08-04 廊坊梅花生物技术开发有限公司 启动子、产苏氨酸重组微生物及其应用
CN114835783A (zh) * 2022-06-01 2022-08-02 宁夏伊品生物科技股份有限公司 NCgl2747基因突变体及其在制备L-赖氨酸中的应用

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