KR20180084756A - 코리네박테리움 글루타미컴으로부터의 프로모터 - Google Patents

코리네박테리움 글루타미컴으로부터의 프로모터 Download PDF

Info

Publication number
KR20180084756A
KR20180084756A KR1020187011781A KR20187011781A KR20180084756A KR 20180084756 A KR20180084756 A KR 20180084756A KR 1020187011781 A KR1020187011781 A KR 1020187011781A KR 20187011781 A KR20187011781 A KR 20187011781A KR 20180084756 A KR20180084756 A KR 20180084756A
Authority
KR
South Korea
Prior art keywords
promoter
corynebacterium glutamicum
glutamicum
corynebacterium
Prior art date
Application number
KR1020187011781A
Other languages
English (en)
Inventor
자흐 서버
캐서린 쥐. 고라
쇼운 피. 맨체스터
Original Assignee
지머젠 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 지머젠 인코포레이티드 filed Critical 지머젠 인코포레이티드
Publication of KR20180084756A publication Critical patent/KR20180084756A/ko

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/04Alpha- or beta- amino acids
    • C12P13/08Lysine; Diaminopimelic acid; Threonine; Valine

Landscapes

  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1020187011781A 2015-12-07 2016-12-07 코리네박테리움 글루타미컴으로부터의 프로모터 KR20180084756A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562264232P 2015-12-07 2015-12-07
US62/264,232 2015-12-07
US201662431409P 2016-12-07 2016-12-07
PCT/US2016/065464 WO2017100376A2 (en) 2015-12-07 2016-12-07 Promoters from corynebacterium glutamicum
US62/431,409 2016-12-07

Publications (1)

Publication Number Publication Date
KR20180084756A true KR20180084756A (ko) 2018-07-25

Family

ID=57868324

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020187011781A KR20180084756A (ko) 2015-12-07 2016-12-07 코리네박테리움 글루타미컴으로부터의 프로모터

Country Status (6)

Country Link
US (2) US11293029B2 (ko)
JP (1) JP6821598B2 (ko)
KR (1) KR20180084756A (ko)
BR (1) BR112018011503A2 (ko)
CA (1) CA3007635A1 (ko)
WO (1) WO2017100376A2 (ko)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9988624B2 (en) 2015-12-07 2018-06-05 Zymergen Inc. Microbial strain improvement by a HTP genomic engineering platform
US11208649B2 (en) 2015-12-07 2021-12-28 Zymergen Inc. HTP genomic engineering platform
KR20180084756A (ko) 2015-12-07 2018-07-25 지머젠 인코포레이티드 코리네박테리움 글루타미컴으로부터의 프로모터
JP2019519241A (ja) 2016-06-30 2019-07-11 ザイマージェン インコーポレイテッド グルコース透過酵素ライブラリーを生成するための方法およびその使用
JP2019519242A (ja) 2016-06-30 2019-07-11 ザイマージェン インコーポレイテッド 細菌ヘモグロビンライブラリーを生成するための方法およびその使用
JP2019519243A (ja) 2016-07-05 2019-07-11 ザイマージェン インコーポレイテッド Rnaデグラドソームタンパク質複合体の遺伝的攪乱
CA3061731A1 (en) 2017-05-19 2018-11-22 Zymergen Inc. Genomic engineering of biosynthetic pathways leading to increased nadph
CN110719956A (zh) 2017-06-06 2020-01-21 齐默尔根公司 用于改良真菌菌株的高通量基因组工程改造平台
US20200102554A1 (en) 2017-06-06 2020-04-02 Zymergen Inc. High throughput transposon mutagenesis
JP7350659B2 (ja) 2017-06-06 2023-09-26 ザイマージェン インコーポレイテッド Saccharopolyspora spinosaの改良のためのハイスループット(HTP)ゲノム操作プラットフォーム
CA3064612A1 (en) * 2017-06-06 2018-12-13 Zymergen Inc. A htp genomic engineering platform for improving escherichia coli
EP3635592A1 (en) 2017-06-06 2020-04-15 Zymergen, Inc. Prioritization of genetic modifications to increase throughput of phenotypic optimization
CN110869504A (zh) * 2017-06-07 2020-03-06 齐默尔根公司 来自谷氨酸棒状杆菌的启动子及其在调节辅助基因表达中的用途
CN108359669B (zh) * 2018-02-13 2020-04-07 江南大学 一种棒杆菌启动子及其应用
JP2021518128A (ja) 2018-03-20 2021-08-02 ザイマージェン インコーポレイテッド チャイニーズハムスター卵巣細胞の遺伝子操作のためのhtpプラットフォーム
WO2019236848A1 (en) 2018-06-06 2019-12-12 Zymergen Inc. Manipulation of genes involved in signal transduction to control fungal morphology during fermentation and production
WO2020051420A1 (en) * 2018-09-07 2020-03-12 Archer Daniels Midland Company Engineered strains of corynebacteria
US11053515B2 (en) 2019-03-08 2021-07-06 Zymergen Inc. Pooled genome editing in microbes
JP2022524043A (ja) 2019-03-08 2022-04-27 ザイマージェン インコーポレイテッド 微生物の反復ゲノム編集
US11479779B2 (en) 2020-07-31 2022-10-25 Zymergen Inc. Systems and methods for high-throughput automated strain generation for non-sporulating fungi
WO2022191358A1 (ko) * 2021-03-09 2022-09-15 대상 주식회사 L-라이신 생산능이 향상된 코리네박테리움 글루타미쿰 변이주 및 이를 이용한 l-라이신의 생산 방법
CN112695036B (zh) * 2021-03-23 2021-07-06 中国科学院天津工业生物技术研究所 一种天冬氨酸激酶基因表达调控序列及其应用
CN115449519B (zh) * 2021-06-08 2023-04-07 中国科学院天津工业生物技术研究所 基于dapB基因的具有启动子活性的多核苷酸及其用途
WO2022265130A1 (ko) * 2021-06-15 2022-12-22 씨제이제일제당 (주) 신규 프로모터 및 이의 용도
CN116536310A (zh) * 2022-01-26 2023-08-04 廊坊梅花生物技术开发有限公司 启动子、产苏氨酸重组微生物及其应用
WO2023231547A1 (zh) * 2022-06-01 2023-12-07 宁夏伊品生物科技股份有限公司 NCgl2747基因突变体及其在制备L-赖氨酸中的应用

Family Cites Families (204)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU507634A1 (ru) 1973-09-24 1976-03-25 Институт Микробиологии Имени А.Кирхенштейна Ан Латвийской Сср Способ получени -лизина
JPS5835197A (ja) 1981-08-26 1983-03-01 Kyowa Hakko Kogyo Co Ltd プラスミドpcg2
US4435504A (en) 1982-07-15 1984-03-06 Syva Company Immunochromatographic assay with support having bound "MIP" and second enzyme
US4601983A (en) 1983-06-15 1986-07-22 Ajinomoto Co., Inc. Coryneform bacteria carrying recombinant plasmids and their use in the fermentative production of L-threonine and L-isoleucine
US4601893A (en) 1984-02-08 1986-07-22 Pfizer Inc. Laminate device for controlled and prolonged release of substances to an ambient environment and method of use
GB8406752D0 (en) 1984-03-15 1984-04-18 Unilever Plc Chemical and clinical tests
GB2165546B (en) 1984-08-21 1989-05-17 Asahi Chemical Ind A plasmid containing a gene for tetracycline resistance and dna fragments derived therefrom
JPH0655149B2 (ja) 1985-03-12 1994-07-27 協和醗酵工業株式会社 L―リジンの製造法
DK122686D0 (da) 1986-03-17 1986-03-17 Novo Industri As Fremstilling af proteiner
CA1303983C (en) 1987-03-27 1992-06-23 Robert W. Rosenstein Solid phase assay
US4855240A (en) 1987-05-13 1989-08-08 Becton Dickinson And Company Solid phase assay employing capillary flow
JPH01225487A (ja) 1988-03-04 1989-09-08 Sakai Eng Kk セルロースのアスペルギルス ニガーによるクエン酸若しくはグルコン酸生産を目的としたバイオリアクター担体への利用方法
JP2748418B2 (ja) 1988-08-03 1998-05-06 味の素株式会社 組換えdna、該組換えdnaを有する微生物
US5976843A (en) 1992-04-22 1999-11-02 Ajinomoto Co., Inc. Bacterial strain of Escherichia coli BKIIM B-3996 as the producer of L-threonine
WO1991006628A1 (en) 1989-10-30 1991-05-16 Exogene Corporation Expression of bacterial hemoglobin and enhancement of expression of cloned and native products in streptomyces
JP3023615B2 (ja) 1990-08-30 2000-03-21 協和醗酵工業株式会社 発酵法によるl―トリプトファンの製造法
DE4027453A1 (de) 1990-08-30 1992-03-05 Degussa Neue plasmide aus corynebacterium glutamicum und davon abgeleitete plasmidvektoren
DE69119083T2 (de) 1990-09-27 1996-10-17 Invitrogen Corp Direkte klonierung von pcr amplifizierten nukleinsäuren
US6060296A (en) 1991-07-03 2000-05-09 The Salk Institute For Biological Studies Protein kinases
DE4130867A1 (de) 1991-09-17 1993-03-18 Degussa Verfahren zur fermentativen herstellung von aminosaeuren
US5516670A (en) 1991-09-30 1996-05-14 Kuehnle; Adelheid R. Magnetophoretic particle delivery method and apparatus for the treatment of cells
EP0635574B1 (en) 1993-07-23 2003-04-23 Dsm N.V. Selection marker gene free recombinant strains, a method for obtaining them and the use of these strains
US6335160B1 (en) 1995-02-17 2002-01-01 Maxygen, Inc. Methods and compositions for polypeptide engineering
US5834252A (en) 1995-04-18 1998-11-10 Glaxo Group Limited End-complementary polymerase reaction
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US5928905A (en) 1995-04-18 1999-07-27 Glaxo Group Limited End-complementary polymerase reaction
US5837458A (en) 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6090592A (en) 1994-08-03 2000-07-18 Mosaic Technologies, Inc. Method for performing amplification of nucleic acid on supports
DE4440118C1 (de) 1994-11-11 1995-11-09 Forschungszentrum Juelich Gmbh Die Genexpression in coryneformen Bakterien regulierende DNA
HU223706B1 (hu) 1994-12-09 2004-12-28 Ajinomoto Co., Inc. Új lizin dekarboxiláz gén és eljárás L-lizin termelésére
AU706285B2 (en) 1995-05-16 1999-06-10 Ajinomoto Co., Inc. Feed additive
GB2304718B (en) 1995-09-05 2000-01-19 Degussa The production of tryptophan by the bacterium escherichia coli
US6479258B1 (en) 1995-12-07 2002-11-12 Diversa Corporation Non-stochastic generation of genetic vaccines
US6713279B1 (en) 1995-12-07 2004-03-30 Diversa Corporation Non-stochastic generation of genetic vaccines and enzymes
US6358709B1 (en) 1995-12-07 2002-03-19 Diversa Corporation End selection in directed evolution
US6537776B1 (en) 1999-06-14 2003-03-25 Diversa Corporation Synthetic ligation reassembly in directed evolution
US20030215798A1 (en) 1997-06-16 2003-11-20 Diversa Corporation High throughput fluorescence-based screening for novel enzymes
DE19548222A1 (de) 1995-12-22 1997-06-26 Forschungszentrum Juelich Gmbh Verfahren zur mikrobiellen Herstellung von Aminosäuren durch gesteigerte Aktivität von Exportcarriern
JPH09224661A (ja) 1996-02-23 1997-09-02 Mitsubishi Chem Corp グルコース−6−リン酸デヒドロゲナーゼおよびそれをコードするdna
US5753477A (en) 1996-03-19 1998-05-19 University Technology Corporation Magneto-biolistic methods
WO1998017809A1 (en) 1996-10-18 1998-04-30 Baxter Biotech Technology S.A.R.L. Methods of reducing the levels of protoporphyrin ix in recombinant hemoglobin preparations
US7148054B2 (en) 1997-01-17 2006-12-12 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
US6326204B1 (en) 1997-01-17 2001-12-04 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
EP2261373A3 (en) 1997-01-17 2011-12-14 Codexis Mayflower Holdings, LLC Evolution of whole cells and organisms by recursive sequence recombination
JPH10229891A (ja) 1997-02-20 1998-09-02 Mitsubishi Rayon Co Ltd マロン酸誘導体の製造法
EP2327797B1 (en) 1997-04-01 2015-11-25 Illumina Cambridge Limited Method of nucleic acid sequencing
JPH1180185A (ja) 1997-09-05 1999-03-26 Res Dev Corp Of Japan オリゴヌクレオチドの化学合成法
DE19831609B4 (de) 1997-10-04 2009-11-12 Evonik Degussa Gmbh Verfahren zur Herstellung von Aminosäuren der Aspartat- und/oder Glutamatfamilie und im Verfahren einsetzbare Mittel
US5990350A (en) 1997-12-16 1999-11-23 Archer Midland Company Process for making granular L-lysine
AR021833A1 (es) 1998-09-30 2002-08-07 Applied Research Systems Metodos de amplificacion y secuenciacion de acido nucleico
KR100618495B1 (ko) 1998-10-06 2006-08-31 마크 아론 에말파브 섬유상의 진균성 숙주 영역에서의 형질전환 시스템:크리소스포륨속에서
US6759195B1 (en) 1999-03-25 2004-07-06 University Of Maryland Biotechnology Institute Method of differential display of prokaryotic messenger RNA by RTPCR
US6300070B1 (en) 1999-06-04 2001-10-09 Mosaic Technologies, Inc. Solid phase methods for amplifying multiple nucleic acids
US20030049804A1 (en) 1999-06-25 2003-03-13 Markus Pompejus Corynebacterium glutamicum genes encoding metabolic pathway proteins
KR20070087035A (ko) 1999-06-25 2007-08-27 바스프 악티엔게젤샤프트 대사 경로 단백질을 코딩하는 코리네박테리움 글루타미쿰유전자
US6962989B1 (en) 1999-07-08 2005-11-08 Basf Aktiengesellschaft Corynebacterium glutamicum genes encoding novel proteins
US20060269975A1 (en) 1999-07-16 2006-11-30 Basf Aktiengesellschaft Corynebacterium glutamicum genes encoding proteins involved in DNA replication, protein synthesis, and pathogenesis
US6746870B1 (en) 1999-07-23 2004-06-08 The Regents Of The University Of California DNA recombination in eukaryotic cells by the bacteriophage PHIC31 recombination system
EP1208193A1 (en) 1999-08-12 2002-05-29 Maxygen, Inc. Dna shuffling of dioxygenase genes for production of industrial chemicals
AU7703400A (en) 1999-09-14 2001-04-17 Xenoport, Inc. Substrates and screening methods for transport proteins
US6586214B1 (en) 1999-09-15 2003-07-01 Degussa Ag Method for increasing the metabolic flux through the pentose phosphate cycle in coryneform bacteria by regulation of the phosphoglucose isomerase (pgi gene)
US7033781B1 (en) 1999-09-29 2006-04-25 Diversa Corporation Whole cell engineering by mutagenizing a substantial portion of a starting genome, combining mutations, and optionally repeating
US6713289B2 (en) 1999-10-05 2004-03-30 Degussa Ag Nucleotide sequences which code for the eno gene
DE19947791A1 (de) 1999-10-05 2001-04-12 Degussa Neue für das eno-Gen codierende Nukleotidsequenzen
DE19950409A1 (de) 1999-10-20 2001-04-26 Degussa Neue für das pck-Gen codierende Nukleotidsequenzen
DE19951975A1 (de) 1999-10-28 2001-05-03 Degussa Neue für das poxB-Gen codierende Nuleotidsequenzen
DE19959327A1 (de) 1999-12-09 2001-06-13 Degussa Neue für das zwa2-Gen codierende Nukleotidsequenzen
DE19959328A1 (de) 1999-12-09 2001-06-13 Degussa Neue für das zwa1-Gen codierende Nukleotidsequenzen
JP4623825B2 (ja) 1999-12-16 2011-02-02 協和発酵バイオ株式会社 新規ポリヌクレオチド
US20020081673A1 (en) 2000-06-02 2002-06-27 Bettina Mockel Novel nucleotide sequences coding for the glbO gene
SE0002460D0 (sv) 2000-06-29 2000-06-29 Roslyn Bill Modified yeast
WO2002029032A2 (en) 2000-09-30 2002-04-11 Diversa Corporation Whole cell engineering by mutagenizing a substantial portion of a starting genome, combining mutations, and optionally repeating
EP1415160A2 (en) 2000-09-30 2004-05-06 Diversa Corporation Whole cell engineering by mutagenizing a substantial portion of a starting genome, combining mutations, and optionally repeating
EP2189473A3 (en) 2000-10-27 2010-08-11 Novartis Vaccines and Diagnostics S.r.l. Nucleic and proteins from streptococcus groups A & B
US7711490B2 (en) 2001-01-10 2010-05-04 The Penn State Research Foundation Method and system for modeling cellular metabolism
US20020169562A1 (en) 2001-01-29 2002-11-14 Gregory Stephanopoulos Defining biological states and related genes, proteins and patterns
US7127379B2 (en) 2001-01-31 2006-10-24 The Regents Of The University Of California Method for the evolutionary design of biochemical reaction networks
WO2002070650A2 (en) 2001-02-13 2002-09-12 Massachusetts Institute Of Technology Dynamic whole genome screening methodology and systems
GB0110432D0 (en) 2001-04-27 2001-06-20 Plant Bioscience Ltd Lantibiotic production
US7160711B2 (en) 2001-08-06 2007-01-09 Degussa Ag Coryneform bacteria which produce chemical compounds I
EP1414970A2 (en) 2001-08-06 2004-05-06 Degussa AG Production of l-lysine by genetically modified corynebacterium glutamicum strains
WO2003014330A2 (en) 2001-08-06 2003-02-20 Degussa Ag Coryneform bacteria which produce chemical compounds ii
JP2003219807A (ja) 2002-01-25 2003-08-05 Ajinomoto Co Inc L−リジンを主成分とする造粒乾燥物
US7826975B2 (en) 2002-07-10 2010-11-02 The Penn State Research Foundation Method for redesign of microbial production systems
US7563600B2 (en) 2002-09-12 2009-07-21 Combimatrix Corporation Microarray synthesis and assembly of gene-length polynucleotides
US20050079617A1 (en) 2003-10-03 2005-04-14 Cervin Marguerite A. Glucose transport mutants for production of biomaterial
AU2003282687A1 (en) 2002-10-04 2004-05-04 Genencor International, Inc. Glucose transport mutants for production of biomaterial
US20040115304A1 (en) 2002-12-16 2004-06-17 Frank Dubner Feesdstuffs additives containing L-lysine with improved abrasion resistance, and process for their production
DE10331366A1 (de) 2003-07-11 2005-01-27 Degussa Ag Verfahren zur Granulation eines Tierfuttermittel-Zusatzes
WO2005021772A1 (en) 2003-08-29 2005-03-10 Degussa Ag Process for the preparation of l-lysine
WO2006017371A1 (en) 2004-07-20 2006-02-16 Novozymes, Inc. Methods of producing mutant polynucleotides
EP2434015B1 (en) * 2004-09-09 2013-11-20 Research Institute Of Innovative Technology For The Earth DNA fragment having promoter function
US20070166792A1 (en) 2004-09-15 2007-07-19 Olson John S Increasing hemoglobin and other heme protein production in bacteria by co-expression of heme transport genes
US7987056B2 (en) 2004-09-20 2011-07-26 The Regents Of The University Of Colorado, A Body Corporate Mixed-library parallel gene mapping quantitative micro-array technique for genome-wide identification of trait conferring genes
DE102004061846A1 (de) * 2004-12-22 2006-07-13 Basf Ag Mehrfachpromotoren
CA2598792A1 (en) 2005-03-02 2006-09-08 Metanomics Gmbh Process for the production of fine chemicals
EP1871910A4 (en) 2005-04-05 2009-07-29 Scripps Research Inst COMPOSITIONS AND METHODS FOR IMPROVING DRUG SENSITIVITY AND TREATING DRUG-RESISTANT INFECTIONS AND DISEASES
MX2007013870A (es) 2005-05-05 2008-01-24 Monsanto Technology Llc Plantas que contienen un gen heterologo de flavohemoglobina y sus metodos de uso.
KR20070009269A (ko) 2005-07-15 2007-01-18 한국생명공학연구원 재조합단백질 생산용 단백질융합인자 라이브러리 및이로부터 획득된 단백질융합인자
US20090298136A1 (en) 2005-07-18 2009-12-03 Basf Ag Methionine producing recombinant microorganisms
US7846688B2 (en) 2005-08-15 2010-12-07 The Regents Of The University Of Colorado Broad host range vectors for shotgun and expression library cloning in Gram negative bacteria
DE102005048818A1 (de) 2005-10-10 2007-04-12 Degussa Ag Mikrobiologische Herstellung von 3-Hydroxypropionsäure
KR100789271B1 (ko) 2005-11-30 2008-01-02 씨제이 주식회사 L-라이신 생산능이 향상된 코리네박테리움 속 미생물 및그를 이용하여 l-라이신을 생산하는 방법
US7498413B2 (en) 2006-01-06 2009-03-03 Pioneer Hi-Bred International, Inc. Maize antimicrobial protein useful for enhancing plant resistance to pathogens
WO2007130745A1 (en) 2006-03-15 2007-11-15 Regents Of The University Of Colorado Enhanced alcohol tolerant microorganism and methods of use thereof
US8445639B2 (en) 2006-05-15 2013-05-21 Avidbiotics Corporation Recombinant bacteriophage and methods for their use
WO2007142954A2 (en) 2006-05-30 2007-12-13 Dow Global Technologies Inc. Codon optimization method
GB0611444D0 (en) 2006-06-09 2006-07-19 Medical Res Council Technology Rnase H2 complex and genes therefor
US20100048938A1 (en) 2006-06-22 2010-02-25 Marco Alexander Van Den Berg Fermentation of pravastatin
US8697364B2 (en) 2006-06-26 2014-04-15 Dsm Ip Assets B.V. High throughput transfection of filamentous fungi
WO2008021765A2 (en) 2006-08-08 2008-02-21 Regents Of The University Of Colorado Compositions and methods for chemical reporter vectors
US9862956B2 (en) 2006-12-10 2018-01-09 Danisco Us Inc. Expression and high-throughput screening of complex expressed DNA libraries in filamentous fungi
EP2126042A4 (en) 2007-01-12 2010-08-04 Univ Colorado Regents COMPOSITIONS AND METHODS FOR IMPROVING THE PRODUCTION TOLERANCE OF ORGANIC CHEMICALS FROM MICROORGANISMS
KR100789274B1 (ko) 2007-01-15 2008-01-02 씨제이 주식회사 코리네박테리움 글루타미쿰에서 유래한 신규한 프로모터핵산 분자, 그 프로모터를 포함하는 재조합 벡터, 그재조합 벡터를 포함하는 숙주 세포 및 그 숙주 세포를이용하여 유전자를 발현하는 방법
WO2008121911A2 (en) 2007-03-30 2008-10-09 Virginia Tech Intellectual Properties, Inc. Software for design and verification of synthetic genetic constructs
US9580719B2 (en) 2007-04-27 2017-02-28 Pfenex, Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
WO2009037279A1 (en) 2007-09-18 2009-03-26 Basf Plant Science Gmbh Plants with increased yield
WO2009043372A1 (en) 2007-10-02 2009-04-09 Metabolic Explorer Increasing methionine yield
MX2010011068A (es) 2008-04-08 2010-11-04 Amyris Biotechnologies Inc Expresion de secuencias heterologas.
AU2009273953B2 (en) 2008-07-23 2013-08-29 Opx Biotechnologies, Inc Methods, systems and compositions for increased microorganism tolerance to and production of 3-hydroxypropionic acid (3-HP)
WO2010025310A2 (en) 2008-08-27 2010-03-04 Westend Asset Clearinghouse Company, Llc Methods and devices for high fidelity polynucleotide synthesis
WO2010024267A1 (ja) 2008-09-01 2010-03-04 国立大学法人信州大学 有用物質の製造法
JP2012504390A (ja) 2008-09-30 2012-02-23 ノボザイムス,インコーポレイティド 糸状菌細胞におけるポジティブ及びネガティブ選択遺伝子の使用方法
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
AU2009316660B2 (en) 2008-11-19 2015-01-29 Amrys, Inc. Compositions and methods for the assembly of polynucleotides
CN102712858B (zh) 2008-11-28 2015-08-12 索拉兹米公司 在重组异养型微生物中制备特制油
WO2010075424A2 (en) 2008-12-22 2010-07-01 The Regents Of University Of California Compositions and methods for downregulating prokaryotic genes
WO2010094772A1 (en) 2009-02-20 2010-08-26 Febit Holding Gmbh Synthesis of sequence-verified nucleic acids
US20130217132A1 (en) 2009-05-01 2013-08-22 Ryan T. Gill Methods, compositions and use for enhancing chemical tolerance by microorganisms
US20100317115A1 (en) 2009-05-01 2010-12-16 Ryan Gill Methods, compositions and uses for enhancing chemical tolerance by microorganisms
US8574835B2 (en) 2009-05-29 2013-11-05 Life Technologies Corporation Scaffolded nucleic acid polymer particles and methods of making and using
WO2010141468A1 (en) 2009-06-01 2010-12-09 Way Jeffrey C Methods and molecules for yield improvement involving metabolic engineering
US10541046B2 (en) 2009-09-02 2020-01-21 Microsoft Technology Licensing, Llc Creating genetic devices
BR112012006801A2 (pt) 2009-09-27 2018-04-10 Opx Biotechnologies Inc método para produção de ácido 3-hidroxipropiônico e outros produtos
GB2492256A (en) 2010-01-27 2012-12-26 Opx Biotechnologies Inc Microorganism production of high-valve chemical products, and related compositions, methods and systems
US10087431B2 (en) 2010-03-10 2018-10-02 The Regents Of The University Of California Methods of generating nucleic acid fragments
EP2576796B1 (en) 2010-06-03 2017-03-29 Danisco US Inc. Filamentous fungal host strains and dna constructs, and methods of use thereof
EP2395087A1 (en) 2010-06-11 2011-12-14 Icon Genetics GmbH System and method of modular cloning
WO2012082720A2 (en) 2010-12-13 2012-06-21 Myriant Corporation Method of producing succinic acid and other chemicals using sucrose-containing feedstock
WO2012142591A2 (en) 2011-04-14 2012-10-18 The Regents Of The University Of Colorado Compositions, methods and uses for multiplex protein sequence activity relationship mapping
US20120264902A1 (en) 2011-04-18 2012-10-18 The Regents Of The University Of Colorado, A Body Corporate Methods, Systems and Compositions for Increased Microorganism Tolerance to and Production of 3-Hydroxypropionic Acid (3-HP)
JP6158170B2 (ja) 2011-04-27 2017-07-12 アミリス, インコーポレイテッド ゲノム修飾のための方法
US8741603B2 (en) 2011-05-03 2014-06-03 Agrigenetics Inc. Enhancing spinosyn production with oxygen binding proteins
US20140113376A1 (en) 2011-06-01 2014-04-24 Rotem Sorek Compositions and methods for downregulating prokaryotic genes
US9752176B2 (en) 2011-06-15 2017-09-05 Ginkgo Bioworks, Inc. Methods for preparative in vitro cloning
CN103732744A (zh) 2011-06-15 2014-04-16 Gen9股份有限公司 制备性体外克隆的方法
DE102011118019A1 (de) * 2011-06-28 2013-01-03 Evonik Degussa Gmbh Varianten des Promotors des für die Glyzerinaldehyd-3-phosphat-Dehydrogenase kodierenden gap-Gens
US9506167B2 (en) 2011-07-29 2016-11-29 Ginkgo Bioworks, Inc. Methods and systems for cell state quantification
US9803221B2 (en) 2011-09-30 2017-10-31 Enchi Corporation Engineering microorganisms to increase ethanol production by metabolic redirection
EP2766389B1 (en) 2011-10-12 2017-03-29 Sanofi Gene cluster for biosynthesis of griselimycin and methylgriselimycin
US8349587B2 (en) 2011-10-31 2013-01-08 Ginkgo Bioworks, Inc. Methods and systems for chemoautotrophic production of organic compounds
US8332160B1 (en) 2011-11-17 2012-12-11 Amyris Biotechnologies, Inc. Systems and methods for engineering nucleic acid constructs using scoring techniques
US9637739B2 (en) 2012-03-20 2017-05-02 Vilnius University RNA-directed DNA cleavage by the Cas9-crRNA complex
WO2013139555A1 (en) 2012-03-21 2013-09-26 Ventana Medical Systems, Inc. Cryoembedded cell concentrates, methods for making, and methods for using
MX362866B (es) 2012-05-25 2019-02-20 Univ California Metodos y composiciones para la modificacion de adn objetivo dirigida por arn y para la modulacion de la transcripcion dirigida por arn.
WO2014011800A1 (en) 2012-07-10 2014-01-16 Pivot Bio, Inc. Methods for multipart, modular and scarless assembly of dna molecules
CN103031327B (zh) 2012-08-02 2015-11-25 华东理工大学 原核细菌光诱导基因表达系统及其调控基因表达的方法
US9506087B2 (en) 2012-08-07 2016-11-29 Codexis, Inc. Glucose and xylose co-utilization in E. coli
WO2014089436A1 (en) 2012-12-07 2014-06-12 Ginkgo Bioworks, Inc. Methods and systems for methylotrophic production of organic compounds
CN113528577A (zh) 2012-12-12 2021-10-22 布罗德研究所有限公司 用于序列操纵的系统、方法和优化的指导组合物的工程化
US20140310830A1 (en) 2012-12-12 2014-10-16 Feng Zhang CRISPR-Cas Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes
US20140189896A1 (en) 2012-12-12 2014-07-03 Feng Zhang Crispr-cas component systems, methods and compositions for sequence manipulation
AU2013359212B2 (en) 2012-12-12 2017-01-19 Massachusetts Institute Of Technology Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation
US8697359B1 (en) 2012-12-12 2014-04-15 The Broad Institute, Inc. CRISPR-Cas systems and methods for altering expression of gene products
US8993233B2 (en) 2012-12-12 2015-03-31 The Broad Institute Inc. Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains
US20140180660A1 (en) 2012-12-14 2014-06-26 Life Technologies Holdings Pte Limited Methods and systems for in silico design
US10102335B2 (en) 2012-12-19 2018-10-16 Virginia Commonwealth University Cost-optimized design analysis for rapid microbial prototyping
WO2014102782A1 (en) 2012-12-24 2014-07-03 Ramot At Tel-Aviv University Ltd Compositions and methods of killing bacteria
RS60259B1 (sr) 2013-09-11 2020-06-30 Impossible Foods Inc Izlučivanje polipeptida koji obuhvataju hem
WO2015070193A1 (en) 2013-11-11 2015-05-14 Liu Oliver Compositions and methods for targeted gene disruption in prokaryotes
US9617569B2 (en) 2013-11-15 2017-04-11 Samsung Electronics Co., Ltd. Genetically engineered yeast cell producing lactate including acetaldehyde dehydrogenase, method of producing yeast cell, and method of producing lactate using the same
CN105992821A (zh) 2013-12-03 2016-10-05 诺维信公司 真菌基因文库的双分裂标记物整合
US11028449B2 (en) 2013-12-31 2021-06-08 Biota Technology, Inc. Microbiome based systems, apparatus and methods for monitoring and controlling industrial processes and systems
US11047232B2 (en) 2013-12-31 2021-06-29 Biota Technology, Inc Microbiome based systems, apparatus and methods for the exploration and production of hydrocarbons
US20170139078A1 (en) 2013-12-31 2017-05-18 Biota Technology, Inc. Microbiome based systems, apparatus and methods for the exploration and production of hydrocarbons
WO2015120403A1 (en) 2014-02-08 2015-08-13 The Regents Of The University Of Colorado, A Body Corporate Multiplexed linking pcr
KR102496984B1 (ko) 2014-02-11 2023-02-06 더 리전츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코퍼레이트 Crispr 이용의 다중화된 게놈 조작
CA2943775A1 (en) 2014-03-25 2015-10-01 Ginkgo Bioworks, Inc. Methods and genetic systems for cell engineering
US10023889B2 (en) 2014-05-16 2018-07-17 University Of Georgia Research Foundation, Inc. Microbial approach for the production of 5-hydroxytryptophan
SG10201803444YA (en) 2014-06-23 2018-06-28 Regeneron Pharma Nuclease-mediated dna assembly
CN106663146A (zh) 2014-06-27 2017-05-10 南洋理工大学 合成生物学设计及宿主细胞模拟系统和方法
ES2947757T3 (es) 2014-11-05 2023-08-18 Illumina Inc Composiciones de transposasas para reducir el sesgo de inserción
SG10201906070XA (en) 2014-12-31 2019-08-27 Synthetic Genomics Inc Compositions and methods for high efficiency in vivo genome editing
FI3250691T3 (fi) 2015-01-28 2023-08-24 Caribou Biosciences Inc Crispr hybridi dna/rna polynukleotidit ja käyttömenetelmät
CA3149413A1 (en) 2015-04-10 2016-10-13 Feldan Bio Inc. Polypeptide-based shuttle agents for improving the transduction efficiency of polypeptide cargos to the cytosol of target eukaryotic cells, uses thereof, methods and kits relating to same
WO2016196319A1 (en) 2015-05-29 2016-12-08 Radiant Genomics, Inc. Compositions and methods for activating silent gene clusters
US9790490B2 (en) 2015-06-18 2017-10-17 The Broad Institute Inc. CRISPR enzymes and systems
EP4159856A1 (en) 2015-06-18 2023-04-05 The Broad Institute, Inc. Novel crispr enzymes and systems
US9677090B2 (en) 2015-10-23 2017-06-13 Caribou Biosciences, Inc. Engineered nucleic-acid targeting nucleic acids
CA3007840C (en) 2015-12-07 2020-09-15 Zymergen Inc. Microbial strain improvement by a htp genomic engineering platform
US9988624B2 (en) 2015-12-07 2018-06-05 Zymergen Inc. Microbial strain improvement by a HTP genomic engineering platform
US11151497B2 (en) 2016-04-27 2021-10-19 Zymergen Inc. Microbial strain design system and methods for improved large-scale production of engineered nucleotide sequences
KR20180084756A (ko) 2015-12-07 2018-07-25 지머젠 인코포레이티드 코리네박테리움 글루타미컴으로부터의 프로모터
EP3472186A1 (en) 2016-06-17 2019-04-24 National Hellenic Research Foundation Systems for recombinant protein production
US10017760B2 (en) 2016-06-24 2018-07-10 Inscripta, Inc. Methods for generating barcoded combinatorial libraries
JP2019519242A (ja) 2016-06-30 2019-07-11 ザイマージェン インコーポレイテッド 細菌ヘモグロビンライブラリーを生成するための方法およびその使用
JP2019519241A (ja) 2016-06-30 2019-07-11 ザイマージェン インコーポレイテッド グルコース透過酵素ライブラリーを生成するための方法およびその使用
JP2019519243A (ja) 2016-07-05 2019-07-11 ザイマージェン インコーポレイテッド Rnaデグラドソームタンパク質複合体の遺伝的攪乱
WO2018013990A1 (en) 2016-07-15 2018-01-18 Zymergen Inc. Scarless dna assembly and genome editing using crispr/cpf1 and dna ligase
JP2019522031A (ja) 2016-07-28 2019-08-08 ギンゴー バイオワークス, インコーポレイテッド 核酸操作のための装置および方法
WO2017037304A2 (en) 2016-07-28 2017-03-09 Dsm Ip Assets B.V. An assembly system for a eukaryotic cell
WO2018071672A1 (en) 2016-10-12 2018-04-19 The Regents Of The University Of Colorado Novel engineered and chimeric nucleases
CN110869504A (zh) 2017-06-07 2020-03-06 齐默尔根公司 来自谷氨酸棒状杆菌的启动子及其在调节辅助基因表达中的用途

Also Published As

Publication number Publication date
JP2018530991A (ja) 2018-10-25
WO2017100376A3 (en) 2017-08-03
BR112018011503A2 (pt) 2018-12-04
US20220325291A1 (en) 2022-10-13
WO2017100376A9 (en) 2017-12-21
US11293029B2 (en) 2022-04-05
WO2017100376A2 (en) 2017-06-15
JP6821598B2 (ja) 2021-01-27
US20180362991A1 (en) 2018-12-20
CA3007635A1 (en) 2017-06-15

Similar Documents

Publication Publication Date Title
KR20180084756A (ko) 코리네박테리움 글루타미컴으로부터의 프로모터
HK1251256A1 (zh) 启動子變體
AU361189S (en) USB flash drive
AU361223S (en) USB flash drive
DK3445742T3 (da) Krystallin tapentadolphosphat
DK3294287T3 (da) Oxabicycloheptan-prodrugs
HUE051973T2 (hu) Corynebacterium
DK3385386T6 (da) Biosyntetisk carrimycin-gencluster
HUE043622T2 (hu) Tároló
AU361270S (en) USB flash drive
GB201720826D0 (en) Clip
DK3291690T3 (da) Fodersammensætning
GB2553170B (en) Promoter
FR3018564B1 (fr) Insert filete
DK3288391T3 (da) Fodertilsætningsstof
DK3247496T3 (da) Udsugningsapparat med reguleret udsugningsindretning
FI11789U1 (fi) Rehu
UA32324S (uk) Гарпун для монтажного профілю
GB2545684B (en) Fastening Point
UA30670S (uk) Гарпун для монтажного профілю
GB2545242B (en) Improved downlight
GB2561484B (en) Improved downlight
IL247839B (en) muzzle
ITUA20162099A1 (it) Macchina per tempra
UA32432S (uk) Степлер