BR112017000696A2 - Citomegalovírus humano recombinante (hcmv), sua composição imunogênica, seu uso, polinucleotídeo isolado, célula isolada e método de produção de hcmv com deficiênciade pp71 - Google Patents
Citomegalovírus humano recombinante (hcmv), sua composição imunogênica, seu uso, polinucleotídeo isolado, célula isolada e método de produção de hcmv com deficiênciade pp71Info
- Publication number
- BR112017000696A2 BR112017000696A2 BR112017000696A BR112017000696A BR112017000696A2 BR 112017000696 A2 BR112017000696 A2 BR 112017000696A2 BR 112017000696 A BR112017000696 A BR 112017000696A BR 112017000696 A BR112017000696 A BR 112017000696A BR 112017000696 A2 BR112017000696 A2 BR 112017000696A2
- Authority
- BR
- Brazil
- Prior art keywords
- hcmv
- human cytomegalovirus
- deficiency
- production
- recombinant human
- Prior art date
Links
- 241000701024 Human betaherpesvirus 5 Species 0.000 title abstract 5
- 230000007812 deficiency Effects 0.000 title 1
- 230000002163 immunogen Effects 0.000 title 1
- 102000040430 polynucleotide Human genes 0.000 title 1
- 108091033319 polynucleotide Proteins 0.000 title 1
- 239000002157 polynucleotide Substances 0.000 title 1
- 239000000427 antigen Substances 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 239000013598 vector Substances 0.000 abstract 2
- 230000002939 deleterious effect Effects 0.000 abstract 1
- IRSCQMHQWWYFCW-UHFFFAOYSA-N ganciclovir Chemical compound O=C1NC(N)=NC2=C1N=CN2COC(CO)CO IRSCQMHQWWYFCW-UHFFFAOYSA-N 0.000 abstract 1
- 229960002963 ganciclovir Drugs 0.000 abstract 1
- 230000002779 inactivation Effects 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
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Abstract
citomegalovírus humano compreendendo antigénios exógenos são revelados vectores de citomegalovírus humanos compreendendo antigénios heterólogos. os vectores derivados a partir da estirpe tr, são sensíveis ao ganciclovir, incluem us2, us3 activo, us6, us7 e ul131a genes, e têm uma mutação deletéria ou inactivação no gene ul82 prevenir a expressão de pp71.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462025348P | 2014-07-16 | 2014-07-16 | |
US62/025,348 | 2014-07-16 | ||
PCT/US2015/040807 WO2016011293A1 (en) | 2014-07-16 | 2015-07-16 | Human cytomegalovirus comprising exogenous antigens |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112017000696A2 true BR112017000696A2 (pt) | 2019-05-14 |
BR112017000696B1 BR112017000696B1 (pt) | 2023-10-03 |
Family
ID=53776978
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017000696-0A BR112017000696B1 (pt) | 2014-07-16 | 2015-07-16 | Polinucleotídeo isolado |
Country Status (16)
Country | Link |
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US (3) | US10428118B2 (pt) |
EP (2) | EP4194558A1 (pt) |
JP (4) | JP6487026B2 (pt) |
KR (3) | KR102205348B1 (pt) |
CN (2) | CN107002048B (pt) |
AP (1) | AP2017009743A0 (pt) |
AU (2) | AU2015289560B2 (pt) |
BR (1) | BR112017000696B1 (pt) |
CA (2) | CA2955306C (pt) |
EA (1) | EA039174B1 (pt) |
IL (1) | IL250130B (pt) |
MX (2) | MX2017000658A (pt) |
NZ (1) | NZ728208A (pt) |
SG (2) | SG10201907249WA (pt) |
UA (1) | UA120938C2 (pt) |
WO (1) | WO2016011293A1 (pt) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
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LT3333265T (lt) | 2010-05-14 | 2020-05-25 | Oregon Health & Science University | Rekombinantiniai žcmv ir rhcmv vektoriai, koduojantys heterologinį antigeną, išskirtą iš hepatito b viruso, ir jų panaudojimas |
PL2691530T3 (pl) | 2011-06-10 | 2019-02-28 | Oregon Health & Science University | Glikoproteiny i rekombinowane wektory CMV |
JP6483033B2 (ja) | 2013-03-05 | 2019-03-13 | オレゴン・ヘルス・アンド・サイエンス・ユニバーシティOregon Health & Science University | T細胞ターゲティングを調節することができるサイトメガロウイルスベクター |
CN107002048B (zh) * | 2014-07-16 | 2021-07-06 | 俄勒冈健康与科学大学 | 包含外源抗原的人巨细胞病毒 |
MA40783A (fr) | 2014-10-03 | 2017-08-08 | Los Alamos Nat Security Llc | Vaccins contre le vih comprenant un ou plusieurs antigènes episensus de population |
EP3256595A4 (en) | 2015-02-10 | 2018-09-26 | Oregon Health & Science University | Methods and compositions useful in generating non canonical cd8+ t cell responses |
MA43285A (fr) | 2015-11-20 | 2018-09-26 | Univ Oregon Health & Science | Vecteurs cmv comprenant des éléments de reconnaissance des microarn |
EP3475446A1 (en) * | 2016-06-27 | 2019-05-01 | Juno Therapeutics, Inc. | Method of identifying peptide epitopes, molecules that bind such epitopes and related uses |
MX2019004518A (es) | 2016-10-18 | 2019-06-17 | Univ Oregon Health & Science | Vectores de citomegalovirus que provocan celulas t restringidas por moleculas del complejo mayor de histocompatibilidad e. |
US11617788B2 (en) | 2018-07-09 | 2023-04-04 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Viral promoters and compositions and methods of use thereof |
GB201906104D0 (en) * | 2019-05-01 | 2019-06-12 | Univ Plymouth | Intrinsic systems for viral vector transgene regulation |
CN117836311A (zh) * | 2021-08-31 | 2024-04-05 | 维尔生物科技公司 | 用于产生cmv载体的方法 |
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