BRPI0918882A2 - métodos, sistemas e composições para tolerância aumentada de microorganismo para produção de ácido 3-hidroxipropiônico (3-hp) - Google Patents

métodos, sistemas e composições para tolerância aumentada de microorganismo para produção de ácido 3-hidroxipropiônico (3-hp)

Info

Publication number
BRPI0918882A2
BRPI0918882A2 BRPI0918882A BRPI0918882A BRPI0918882A2 BR PI0918882 A2 BRPI0918882 A2 BR PI0918882A2 BR PI0918882 A BRPI0918882 A BR PI0918882A BR PI0918882 A BRPI0918882 A BR PI0918882A BR PI0918882 A2 BRPI0918882 A2 BR PI0918882A2
Authority
BR
Brazil
Prior art keywords
compositions
methods
hydroxypropionic acid
systems
production
Prior art date
Application number
BRPI0918882A
Other languages
English (en)
Inventor
d lynch Michael
T Gill Ryan
E Warnecke-Lipscomb Tanya
Original Assignee
Opx Biotechnologies Inc
Univ Colorado Regents
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Opx Biotechnologies Inc, Univ Colorado Regents filed Critical Opx Biotechnologies Inc
Publication of BRPI0918882A2 publication Critical patent/BRPI0918882A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

métodos, sistemas e composições para tolerância aumentada de microorganismo para produção de ácido 3-hidroxipropiônico (3-hp). a presente invenção se refere a métodos, 5 sistema e composições, incluindo um microorganismo geneticamente modificado, adaptado para exibir tolerância aumentadas a ácido 3-hidroxipropiônico (3-hp), particularmente através de alterações inter-relacionadas a caminhos metabólicos identificados como via do complexo toleragênico do 3-hp.
BRPI0918882A 2008-07-23 2009-07-23 métodos, sistemas e composições para tolerância aumentada de microorganismo para produção de ácido 3-hidroxipropiônico (3-hp) BRPI0918882A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US13586108P 2008-07-23 2008-07-23
US13586208P 2008-07-23 2008-07-23
US8833108P 2008-08-12 2008-08-12
US9693708P 2008-09-15 2008-09-15
PCT/US2009/051607 WO2010011874A2 (en) 2008-07-23 2009-07-23 Methods, systems and compositions for increased microorganism tolerance to and production of 3-hydroxypropionic acid (3-hp)

Publications (1)

Publication Number Publication Date
BRPI0918882A2 true BRPI0918882A2 (pt) 2019-02-26

Family

ID=41570872

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0918882A BRPI0918882A2 (pt) 2008-07-23 2009-07-23 métodos, sistemas e composições para tolerância aumentada de microorganismo para produção de ácido 3-hidroxipropiônico (3-hp)

Country Status (8)

Country Link
US (2) US20110244575A1 (pt)
EP (1) EP2318514A4 (pt)
CN (1) CN102317436B (pt)
AU (1) AU2009273953B2 (pt)
BR (1) BRPI0918882A2 (pt)
CA (1) CA2731509A1 (pt)
MX (1) MX2011000793A (pt)
WO (1) WO2010011874A2 (pt)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0806695A2 (pt) * 2007-01-12 2014-06-03 Univ Colorado Composições e métodos para aumentar a tolerância à produção de produtos químicos produzidos por microorganismos
US8048624B1 (en) 2007-12-04 2011-11-01 Opx Biotechnologies, Inc. Compositions and methods for 3-hydroxypropionate bio-production from biomass
US8647642B2 (en) 2008-09-18 2014-02-11 Aviex Technologies, Llc Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment
US8809027B1 (en) 2009-09-27 2014-08-19 Opx Biotechnologies, Inc. Genetically modified organisms for increased microbial production of 3-hydroxypropionic acid involving an oxaloacetate alpha-decarboxylase
WO2011038364A1 (en) * 2009-09-27 2011-03-31 Opx Biotechnologies, Inc. Method for producing 3-hydroxypropionic acid and other products
JP5706907B2 (ja) * 2009-10-29 2015-04-22 コリア リサーチ インスティテュート オブ バイオサイエンス アンド バイオテクノロジー グリセロールから３−ヒドロキシプロピオン酸を産生する新しい方法
GB2492256A (en) * 2010-01-27 2012-12-26 Opx Biotechnologies Inc Microorganism production of high-valve chemical products, and related compositions, methods and systems
EP2565211B1 (en) 2010-04-26 2017-10-25 Nippon Shokubai Co., Ltd. Polyacrylic acid (salt), polyacrylic acid (salt)-based water-absorbing resin, and process for producing same
BR112013012630B1 (pt) * 2010-11-22 2021-09-08 Novozymes, Inc. Célula de levedura geneticamente modificada, e, método para produzir 3-hp
CA2868113A1 (en) 2011-03-22 2012-09-27 Opx Biotechnologies, Inc. Microbial production of chemical products and related compositions, methods and systems
KR101860442B1 (ko) 2011-06-27 2018-05-24 삼성전자주식회사 3-하이드록시프로피온산의 생산을 위한 유전자 조작
IN2015DN01858A (pt) 2012-08-10 2015-05-29 Opx Biotechnologies Inc
US9587256B2 (en) 2012-09-06 2017-03-07 University Of Georgia Research Foundation, Inc. Sequestration of carbon dioxide with hydrogen to useful products
CA2891130A1 (en) * 2012-11-30 2014-06-05 Novozymes, Inc. 3-hydroxypropionic acid production by recombinant yeasts
BR112015023474B1 (pt) 2013-03-15 2020-10-06 Cargill, Incorporated Método para recuperar uma composição enriquecida em ácido 3-hidroxipropiônico
US9512057B2 (en) 2013-03-15 2016-12-06 Cargill, Incorporated 3-hydroxypropionic acid compositions
US20150057465A1 (en) 2013-03-15 2015-02-26 Opx Biotechnologies, Inc. Control of growth-induction-production phases
US20150044746A1 (en) * 2013-03-15 2015-02-12 Opx Biotechnologies, Inc. Method of enhanced bioproduction
WO2014198841A1 (en) * 2013-06-14 2014-12-18 Technical University Of Denmark 3hp tolerance
US11408013B2 (en) 2013-07-19 2022-08-09 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
JP6603658B2 (ja) 2013-07-19 2019-11-06 カーギル インコーポレイテッド 脂肪酸及び脂肪酸誘導体の製造のための微生物及び方法
KR20150051081A (ko) 2013-11-01 2015-05-11 삼성전자주식회사 전사 인자 조작을 통하여 재프로그래밍된 유전자를 발현하는 내산성이 증가된 클루베로마이세스 마르시아누스
CN103898168B (zh) * 2014-01-16 2017-11-03 华东理工大学 一种安全生产1,3‑丙二醇的方法
JP6730199B2 (ja) 2014-06-11 2020-07-29 デューク ユニバーシティ 合成代謝弁を用いた迅速かつ動的なフラックス制御のための組成物及び方法
EP2993228B1 (en) 2014-09-02 2019-10-09 Cargill, Incorporated Production of fatty acid esters
CN104726389B (zh) * 2015-04-14 2018-11-13 中国科学院青岛生物能源与过程研究所 一种3-羟基丙酸耐受性提高的大肠杆菌及其构建方法
US9988624B2 (en) 2015-12-07 2018-06-05 Zymergen Inc. Microbial strain improvement by a HTP genomic engineering platform
US11293029B2 (en) 2015-12-07 2022-04-05 Zymergen Inc. Promoters from Corynebacterium glutamicum
US11208649B2 (en) 2015-12-07 2021-12-28 Zymergen Inc. HTP genomic engineering platform
JP2019519242A (ja) 2016-06-30 2019-07-11 ザイマージェン インコーポレイテッド 細菌ヘモグロビンライブラリーを生成するための方法およびその使用
US10544411B2 (en) 2016-06-30 2020-01-28 Zymergen Inc. Methods for generating a glucose permease library and uses thereof
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
CN106755056A (zh) * 2016-12-14 2017-05-31 吴银娣 一种酸胁迫抗性提高的毕赤酵母
CN110494566A (zh) 2017-02-02 2019-11-22 嘉吉公司 产生c6-c10脂肪酸衍生物的经遗传修饰的细胞
JP6878607B2 (ja) 2017-02-21 2021-05-26 デューク ユニバーシティ ロバストな動的な代謝コントロールの為の組成物及び方法
CN108728469B (zh) * 2017-04-14 2022-03-01 中国科学院微生物研究所 重组大肠杆菌工程菌的构建及其在生产β-丙氨酸中的应用
US20200095621A1 (en) 2017-05-16 2020-03-26 The Regents Of The University Of California Methods and compositions for 3-hydroxypropionate production
EP3746544A4 (en) 2018-02-01 2021-10-27 INVISTA Textiles (U.K.) Limited PROCESS AND MATERIALS FOR THE BIOSYNTHESIS OF COMPOUNDS INVOLVED IN THE TRICARBONIC ACID CYCLE AND THEIR DERIVATIVES AND COMPOUNDS
CN110295188B (zh) * 2018-03-23 2021-06-15 华东理工大学 一种提高大肠杆菌合成的聚（3-羟基丁酸-co-乳酸）中乳酸组分含量的方法
WO2019246488A1 (en) 2018-06-21 2019-12-26 Duke University Compositions and methods for the production of pyruvic acid and related products using dynamic metabolic control
CN109810991B (zh) * 2019-03-02 2021-11-12 昆明理工大学 二氢蝶酸合酶基因folP的用途
CN110129247B (zh) * 2019-05-13 2021-02-26 中国科学院天津工业生物技术研究所 赖氨酸生产菌株的构建方法和应用
CN110157654B (zh) * 2019-05-21 2020-07-28 江南大学 一种纳豆芽孢杆菌重组菌及其构建方法与应用
CN110172435B (zh) * 2019-06-06 2020-12-29 江南大学 一种催化合成2,5-二甲基吡嗪的重组菌
CN110499343B (zh) * 2019-09-11 2021-06-04 鲁东大学 一种酶法制备4-羟基苯乙醛的方法
CN110564757A (zh) * 2019-09-27 2019-12-13 华东理工大学 利用乙酸或其盐生产3-羟基丙酸的代谢工程大肠杆菌菌株的构建方法及应用
IL295259A (en) * 2020-02-03 2022-10-01 Premas Biotech Private Ltd Recombinant expression platform, constructs and methods for expression of proteins that are difficult to express (dte-ps)
CN111235169A (zh) * 2020-02-03 2020-06-05 昆明理工大学 一种GTP环化水解酶I基因folE及应用
WO2022025710A1 (ko) * 2020-07-31 2022-02-03 주식회사 엘지화학 3-하이드록시프로피온산의 2단계 제조 방법
CN116121160A (zh) * 2022-10-28 2023-05-16 天津科技大学 过表达pyrB基因的基因工程菌及其生产L-精氨酸的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6852517B1 (en) * 1999-08-30 2005-02-08 Wisconsin Alumni Research Foundation Production of 3-hydroxypropionic acid in recombinant organisms
US6627427B1 (en) * 1999-10-25 2003-09-30 Kosan Biosciences, Inc. Heterologous production of 15-methyl-6-deoxyerthronolide B
CN1556855A (zh) * 2000-11-20 2004-12-22 卡吉尔公司 3-羟基丙酸及其它有机化合物
AU2003287028B2 (en) * 2002-10-04 2008-09-04 E.I. Du Pont De Nemours And Company Process for the biological production of 1,3-propanediol with high yield
EP1597364B1 (fr) * 2003-02-18 2013-07-24 Metabolic Explorer Procede de preparation de microorganismes evolues permettant la creation ou la modification de voies metaboliques
ATE543873T1 (de) * 2003-12-04 2012-02-15 Novozymes As Herstellung von 3-hydroxypropionsäure mittels beta-alanine-pyruvat-aminotrransferase
RU2447146C2 (ru) * 2005-07-18 2012-04-10 Эвоник Дегусса Гмбх Рекомбинантные микроорганизмы, продуцирующие метионин
AU2006287257A1 (en) * 2005-09-09 2007-03-15 Genomatica, Inc. Methods and organisms for the growth-coupled production of succinate
WO2008027742A1 (en) * 2006-08-30 2008-03-06 Cargill, Incorporated Beta-alanine/alpha-ketoglutarate aminotransferase for 3-hydroxypropionic acid production
BRPI0806695A2 (pt) * 2007-01-12 2014-06-03 Univ Colorado Composições e métodos para aumentar a tolerância à produção de produtos químicos produzidos por microorganismos
WO2008091627A2 (en) * 2007-01-22 2008-07-31 Genomatica, Inc. Methods and organisms for growth-coupled production of 3-hydroxypropionic acid

Also Published As

Publication number Publication date
CN102317436A (zh) 2012-01-11
WO2010011874A2 (en) 2010-01-28
EP2318514A2 (en) 2011-05-11
WO2010011874A3 (en) 2010-08-05
AU2009273953A1 (en) 2010-01-28
CN102317436B (zh) 2014-06-25
CA2731509A1 (en) 2010-01-28
US20110244575A1 (en) 2011-10-06
MX2011000793A (es) 2011-09-06
AU2009273953B2 (en) 2013-08-29
US20150056684A1 (en) 2015-02-26
EP2318514A4 (en) 2013-08-21

Similar Documents

Publication Publication Date Title
BRPI0918882A2 (pt) métodos, sistemas e composições para tolerância aumentada de microorganismo para produção de ácido 3-hidroxipropiônico (3-hp)
BR112014018737A2 (pt) método para a amplificação de ácidos nucleicos
BR112015018783A2 (pt) mistura íntima seca, composição, método de preparação de uma mistura íntima seca e método de aumento da germinação, crescimento, metabolismo e/ou atividade enzimática de esporos bacterianos
MY158663A (en) Fermentation broth formulations
MX2019004378A (es) Edulcorante de estevia altamente soluble.
BR112012010057A2 (pt) ácido 3-fenilpropiônico substituído e sua aplicação.
BR112015005416A2 (pt) produção de ácidos orgânicos por meio de fermentação em baixo ph
UA105229C2 (uk) Фармацевтичний склад
BR112012024799A2 (pt) método para a produção de l-ornitina por fermentação
BR112012028291A2 (pt) composições farmacêuticas e métodos para sua produção
BRPI0707229B8 (pt) método para produzir um l-aminoácido
ES2531292T3 (es) Derivado oxidado del ácido hialurónico, un método para su preparación y un método para su modificación
MY156518A (en) Borinic compositions
BR112015009603A2 (pt) novos derivados de pirazina
BR112016023498A2 (pt) composições para higiene bucal
BR112013011259A2 (pt) condições de tratamento associadas com nível aumentado de eotaxina com 25-hidroxivitamina d3
BR112015023475A2 (pt) método para recuperar uma composição enriquecida em ácido 3-hidroxipropiônico
BR112012020824A2 (pt) processo para produção de corpos moldados revestidos.
CL2016000746A1 (es) Un método para producir un l-aminoácido usando una bacteria de la familia de las enterobacteriaceae teniendo atenuada la expresión de un gen que codifica un transportador de fosfato
MY157569A (en) Method for producing a solid with sufficiently low hygroscopicity which comprises glutamic acid-n,n-diacetic acid (glda) or a derivative thereof
CY1124624T1 (el) Μητρες οι οποιες περιεχουν εναν τροποποιημενο πολυσακχαριτη
BR112012019920A2 (pt) derivados de piridazina úteis como agonístas de canabinoide-2.
PH12014502071A1 (en) Beta-hydroxy-beta-methylbutyric acid for imrpoving glucose tolerance
BRPI1011630B8 (pt) paracetamol para a administração parenteral
BR112012011786A2 (pt) "método para a produção de derivados de ácido glutâmico marcados por f-18"

Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 8A E 9A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2513 DE 06-03-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

B350 Update of information on the portal [chapter 15.35 patent gazette]