BR112012010057A2 - ácido 3-fenilpropiônico substituído e sua aplicação. - Google Patents

ácido 3-fenilpropiônico substituído e sua aplicação.

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Publication number
BR112012010057A2
BR112012010057A2 BR112012010057A BR112012010057A BR112012010057A2 BR 112012010057 A2 BR112012010057 A2 BR 112012010057A2 BR 112012010057 A BR112012010057 A BR 112012010057A BR 112012010057 A BR112012010057 A BR 112012010057A BR 112012010057 A2 BR112012010057 A2 BR 112012010057A2
Authority
BR
Brazil
Prior art keywords
application
phenylpropionic acid
substituted
prevention
treatment
Prior art date
Application number
BR112012010057A
Other languages
English (en)
Inventor
Knorr Andreas
Becker Eva-Maria
Wunder Frank
Stoll Friederike
Stasch Johannes-Peter
Schlemmer Karl-Heinz
Hahn Michael
El Sheikh Sherif
Lampe Thomas
Min-Jian Li Volkhart
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of BR112012010057A2 publication Critical patent/BR112012010057A2/pt

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    • C07C233/00—Carboxylic acid amides
    • C07C233/88—Carboxylic acid amides having nitrogen atoms of carboxamide groups bound to an acyclic carbon atom and to a carbon atom of a six-membered aromatic ring wherein at least one ortho-hydrogen atom has been replaced
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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    • A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
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    • C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
    • C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
    • C07C205/38—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to a carbon atom of a six-membered aromatic ring, e.g. nitrodiphenyl ethers
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    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
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    • C07C233/53—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/55—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a carbon atom of an unsaturated carbon skeleton
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    • C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
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    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/04—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D305/06—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring atoms
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Abstract

ácido 3-fenilpropiônico substituído e sua aplicação. a presente notificação se refere a novos derivados de ácido 3-fenilpropiônico, método para sua fabricação, sua aplicação para tratamento e/ou prevenção de doenças bem como sua aplicação na fabricação de medicamentos para tratamento e/ou prevenção de doenças, em especial, para tratamento e/ou prevenção de doenças cardiovasculares.
BR112012010057A 2009-10-28 2010-10-21 ácido 3-fenilpropiônico substituído e sua aplicação. BR112012010057A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102009046115A DE102009046115A1 (de) 2009-10-28 2009-10-28 Substituierte 3-Phenylpropansäuren und ihre Verwendung
PCT/EP2010/065910 WO2011051165A1 (de) 2009-10-28 2010-10-21 Substituierte 3-phenylpropionsäuren und ihre verwendung

Publications (1)

Publication Number Publication Date
BR112012010057A2 true BR112012010057A2 (pt) 2019-09-24

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BR112012010057A BR112012010057A2 (pt) 2009-10-28 2010-10-21 ácido 3-fenilpropiônico substituído e sua aplicação.

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US (2) US20110130445A1 (pt)
EP (1) EP2493845B1 (pt)
JP (1) JP5801312B2 (pt)
KR (1) KR20120101411A (pt)
CN (1) CN102712577B (pt)
AR (1) AR079015A1 (pt)
AU (1) AU2010311678B2 (pt)
BR (1) BR112012010057A2 (pt)
CA (1) CA2777152C (pt)
DE (1) DE102009046115A1 (pt)
DK (1) DK2493845T3 (pt)
ES (1) ES2446970T3 (pt)
HK (1) HK1177195A1 (pt)
HR (1) HRP20140270T1 (pt)
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PL (1) PL2493845T3 (pt)
PT (1) PT2493845E (pt)
RU (1) RU2553263C2 (pt)
TW (1) TWI487519B (pt)
UY (1) UY32970A (pt)
WO (1) WO2011051165A1 (pt)
ZA (1) ZA201202465B (pt)

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DE102009012314A1 (de) * 2009-03-09 2010-09-16 Bayer Schering Pharma Aktiengesellschaft Oxo-heterocyclisch substituierte Alkylcarbonsäuren und ihre Verwendung
DE102009046115A1 (de) 2009-10-28 2011-09-08 Bayer Schering Pharma Aktiengesellschaft Substituierte 3-Phenylpropansäuren und ihre Verwendung
EP2549875B1 (en) 2010-03-25 2015-05-13 Merck Sharp & Dohme Corp. Soluble guanylate cyclase activators
WO2011149921A1 (en) 2010-05-27 2011-12-01 Merck Sharp & Dohme Corp. Soluble guanylate cyclase activators
EP2632551B1 (en) 2010-10-28 2016-07-06 Merck Sharp & Dohme Corp. Soluble guanylate cyclase activators
AU2011340721A1 (en) 2010-12-07 2013-06-20 Bayer Intellectual Property Gmbh Substituted 1-benzylcycloalkylcarboxlic acids and use thereof
DE102011007272A1 (de) * 2011-04-13 2012-10-18 Bayer Pharma Aktiengesellschaft Verzweigte 3-Phenylpropionsäure-Derivate und ihre Verwendung
EP2820005A1 (en) * 2012-02-28 2015-01-07 Piramal Enterprises Limited Phenyl alkanoic acid derivatives as gpr agonists
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