BRPI0707229B8 - método para produzir um l-aminoácido - Google Patents

método para produzir um l-aminoácido

Info

Publication number
BRPI0707229B8
BRPI0707229B8 BRPI0707229A BRPI0707229A BRPI0707229B8 BR PI0707229 B8 BRPI0707229 B8 BR PI0707229B8 BR PI0707229 A BRPI0707229 A BR PI0707229A BR PI0707229 A BRPI0707229 A BR PI0707229A BR PI0707229 B8 BRPI0707229 B8 BR PI0707229B8
Authority
BR
Brazil
Prior art keywords
amino acid
produce
proline
leucine
glutamine
Prior art date
Application number
BRPI0707229A
Other languages
English (en)
Inventor
Chinen Akito
Yasueda Hisashi
Nakamura Jun
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Publication of BRPI0707229A2 publication Critical patent/BRPI0707229A2/pt
Publication of BRPI0707229B1 publication Critical patent/BRPI0707229B1/pt
Publication of BRPI0707229B8 publication Critical patent/BRPI0707229B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/10—Citrulline; Arginine; Ornithine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/14—Glutamic acid; Glutamine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/24—Proline; Hydroxyproline; Histidine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

método para produzir um l-aminoácido. l-aminoácidos como ácido l-glutâmico, l-glutamina, l-prolina, l-arginina, l-leucina, e l-cisteína são produzidos por cultivo em um meio de uma bactéria tendo uma capacidade de produzir l-aminoácido e em que a bactéria foi modificada de modo que a atividade de fosfotransacetilase é aumentada.
BRPI0707229A 2006-01-27 2007-01-29 método para produzir um l-aminoácido BRPI0707229B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2006-019562 2006-01-27
JP2006019562 2006-01-27
PCT/JP2007/051837 WO2007086608A1 (en) 2006-01-27 2007-01-29 Method for producing l-amino acid

Publications (3)

Publication Number Publication Date
BRPI0707229A2 BRPI0707229A2 (pt) 2011-04-26
BRPI0707229B1 BRPI0707229B1 (pt) 2016-12-20
BRPI0707229B8 true BRPI0707229B8 (pt) 2017-06-27

Family

ID=37908222

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0707229A BRPI0707229B8 (pt) 2006-01-27 2007-01-29 método para produzir um l-aminoácido

Country Status (6)

Country Link
US (1) US8012722B2 (pt)
EP (1) EP1976995B1 (pt)
CN (1) CN101374953B (pt)
BR (1) BRPI0707229B8 (pt)
PE (1) PE20071235A1 (pt)
WO (1) WO2007086608A1 (pt)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2004124226A (ru) * 2004-08-10 2006-01-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) Использование фосфокетолазы для продукции полезных метаболитов
US7794989B2 (en) * 2004-12-28 2010-09-14 Ajinomoto Co., Inc. L-glutamic acid-producing microorganism and a method for producing L-glutamic acid
JP2012223091A (ja) * 2009-08-25 2012-11-15 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
US8871488B2 (en) 2010-06-18 2014-10-28 Butamax Advanced Biofuels Llc Recombinant host cells comprising phosphoketolases
CN104160024A (zh) * 2011-04-01 2014-11-19 味之素株式会社 用于生产l-半胱氨酸的方法
US8415136B1 (en) 2011-11-09 2013-04-09 Amyris, Inc. Production of acetyl-coenzyme a derived isoprenoids
EP2778228B1 (en) 2011-11-11 2017-05-17 Ajinomoto Co., Inc. Method for producing 2-ketoglutaric acid and derivatives thereof by using a bacterium from the genus pantoea or the genus corynebacterium
WO2015060391A1 (ja) * 2013-10-23 2015-04-30 味の素株式会社 目的物質の製造法
KR101601404B1 (ko) 2014-04-09 2016-03-09 씨제이제일제당 (주) Ｌ-라이신 생산능을 갖는 미생물 및 이를 이용한 ｌ-라이신 생산 방법
KR101735935B1 (ko) * 2015-07-20 2017-05-16 씨제이제일제당 (주) 퓨트레신 또는 오르니틴 생산 미생물 및 이를 이용한 퓨트레신 또는 오르니틴 생산방법
CN106148261B (zh) * 2016-07-01 2019-09-03 江南大学 一种提高乙酰氨基葡萄糖产量的重组枯草芽孢杆菌及其构建方法
CN105566136A (zh) * 2016-01-19 2016-05-11 天津科技大学 一种从发酵液中分离提取4-羟基异亮氨酸的方法
US10428359B2 (en) * 2016-10-03 2019-10-01 Ajinomoto Co, Inc. Method for producing L-amino acid
JP7066977B2 (ja) * 2017-04-03 2022-05-16 味の素株式会社 Ｌ－アミノ酸の製造法
CN111411093B (zh) * 2019-04-30 2021-10-22 中国科学院天津工业生物技术研究所 活性提高的磷酸转酮酶及在生产代谢物中的应用
CN112410389B (zh) * 2019-08-23 2023-07-18 中国科学院微生物研究所 支链α-酮酸脱氢酶复合体在制备丙二酸单酰辅酶A中的应用
CN113025542B (zh) * 2019-12-25 2022-09-16 中国科学院微生物研究所 产l-谷氨酰胺的重组大肠杆菌及其构建方法与应用
CN112143751B (zh) * 2020-09-22 2022-05-06 廊坊梅花生物技术开发有限公司 高产核苷的枯草芽孢杆菌工程菌及其构建方法与应用
KR20230092008A (ko) * 2020-10-28 2023-06-23 아지노모토 가부시키가이샤 L-아미노산의 제조법
CN114107141B (zh) * 2021-08-19 2022-07-12 中国科学院天津工业生物技术研究所 高产l-脯氨酸的谷氨酸棒杆菌以及高产l-脯氨酸的方法
CN114134185B (zh) * 2021-10-30 2024-06-21 新泰市佳禾生物科技有限公司 一种发酵生产l-丝氨酸的方法
CN114277070B (zh) * 2021-11-29 2024-07-09 新泰市佳禾生物科技有限公司 一种发酵生产l-鸟氨酸的方法
CN116536227A (zh) * 2022-01-26 2023-08-04 廊坊梅花生物技术开发有限公司 一种生产苏氨酸的修饰的棒状杆菌属微生物及其构建方法与应用
CN116555131A (zh) * 2022-01-27 2023-08-08 廊坊梅花生物技术开发有限公司 一种重组微生物及其构建方法和应用
CN114478724B (zh) * 2022-04-18 2022-06-24 中国科学院天津工业生物技术研究所 一种ramB突变体及其构建赖氨酸生产菌株的方法
CN114874959B (zh) * 2022-04-27 2024-04-16 天津科技大学 一种利用葡萄糖从头发酵生产l-茶氨酸的基因工程菌、方法及应用
CN117165504A (zh) * 2023-08-03 2023-12-05 天津世纪伟康生物科技有限公司 一种发酵法高效生产γ-氨基丁酸的工程菌及其应用
KR20250078646A (ko) * 2023-11-23 2025-06-04 대상 주식회사 L-글루탐산 생산능이 향상된 변이 미생물 및 이를 이용한 l-글루탐산의 생산 방법

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56144093A (en) 1980-04-14 1981-11-10 Ajinomoto Co Inc Preparation of l-proline by fermentation
US4372753A (en) 1980-04-23 1983-02-08 Source Technology, Inc. Liquid fuel for use in internal combustion engines
JPS56151495A (en) 1980-04-25 1981-11-24 Ajinomoto Co Inc Production of l-glutamine through fermentation
DE3127361A1 (de) 1981-07-08 1983-02-03 Schering Ag, 1000 Berlin Und 4619 Bergkamen Herstellung und anwendung von plasmiden mit genen fuer die biosynthese von l-prolin
JPH0783714B2 (ja) * 1983-08-29 1995-09-13 味の素株式会社 発酵法によるｌ―アミノ酸の製造法
JPS61202694A (ja) 1985-03-07 1986-09-08 Ajinomoto Co Inc 発酵法によるｌ−グルタミンの製造法
JPH03232497A (ja) 1990-02-08 1991-10-16 Asahi Chem Ind Co Ltd 発酵法によるｌ―グルタミンの製造方法
US5569595A (en) 1991-09-27 1996-10-29 Center For Innovative Technology Production of poly-β-hydroxybutyrate in prokaryotic host cells
JPH099982A (ja) * 1995-07-04 1997-01-14 Chikyu Kankyo Sangyo Gijutsu Kenkyu Kiko Ｌ−含硫アミノ酸の製造法
EP1188822B1 (en) 1999-04-09 2007-01-24 Ajinomoto Co., Inc. L-amino acid-producing bacteria and process for producing l-amino acid
JP2001046067A (ja) 1999-08-04 2001-02-20 Ajinomoto Co Inc 好熱性バチルス属細菌由来のｌ−リジン生合成系遺伝子
JP2001120292A (ja) 1999-08-17 2001-05-08 Ajinomoto Co Inc 発酵法によるｌ−アミノ酸の製造法
RU2207376C2 (ru) * 1999-10-14 2003-06-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Способ получения l-аминокислоты методом ферментации, штамм бактерии escherichia coli - продуцент l-аминокислоты (варианты)
RU2207371C2 (ru) 2000-09-26 2003-06-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Способ получения l-аминокислот семейства l-глутаминовой кислоты, штамм бактерии escherichia coli - продуцент l-аминокислоты (варианты)
JP5087194B2 (ja) 2001-02-13 2012-11-28 味の素株式会社 エシェリヒア属細菌を用いたｌ−アミノ酸の製造法
DE60232120D1 (de) 2001-06-12 2009-06-10 Ajinomoto Kk Verfahren zur Herstellung von L-Lysin oder L-Arginin unter Verwendung methanolassimilierender Bakterien
US20050176121A1 (en) 2001-09-06 2005-08-11 Ryo Takeshita Method for producing alcohol by using microorganism
RU2230114C2 (ru) 2001-11-30 2004-06-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Мутантная глутаминсинтетаза, фрагмент днк, штамм escherichia coli - продуцент l-глутамина и способ получения l-аминокислот
SE0200857D0 (sv) 2002-03-19 2002-03-19 Forskarpatent I Syd Ab Metabolic engineering for improved xylose utilisation of saccharomyces cerevisiae
US6911332B2 (en) 2002-06-12 2005-06-28 Ajinomoto Co., Inc. Isolated polynucleotides encoding d-arabino-3-hexulose-6-phosphate synthases from Methylophilus methylotrophus
JP4120364B2 (ja) 2002-11-20 2008-07-16 味の素株式会社 メタノール資化性菌を用いたｌ−リジンまたはｌ−アルギニンの製造法
JP2004166595A (ja) 2002-11-20 2004-06-17 Ajinomoto Co Inc メチロトローフを用いたｌ−アミノ酸の製造法
JP2004166592A (ja) 2002-11-20 2004-06-17 Ajinomoto Co Inc メチロトローフを用いたｌ−アミノ酸の製造法
DE60335774D1 (de) 2002-11-26 2011-03-03 Ajinomoto Kk Methode für die Produktion von L-Glutamin und L-Glutamin-produzierendes Bakterium
DE102004001674B4 (de) 2003-01-29 2019-01-24 Ajinomoto Co., Inc. Verfahren zur Herstellung von L-Lysin unter Einsatz von Methanol verwertenden Bakterien
US7060475B2 (en) 2003-02-28 2006-06-13 Ajinomoto Co., Inc. Polynucleotides encoding polypeptides involved in intermediates metabolism of central metabolic pathway in methylophilus methylotrophus
US7026149B2 (en) 2003-02-28 2006-04-11 Ajinomoto Co., Inc. Polynucleotides encoding polypeptides involved in the stress response to environmental changes in Methylophilus methylotrophus
US7029893B2 (en) 2003-02-28 2006-04-18 Ajinomoto Co., Inc. Polynucleotides encoding polypeptides involved in amino acid biosynthesis in methylophilus methylotrophus
US20060019356A1 (en) 2003-02-28 2006-01-26 Yoshihiro Usuda Polynucleotides encoding polypeptides involved in intermediates metabolism of the central metabolic pathway in Methylophilus methylotrophus
JP2004261150A (ja) 2003-03-04 2004-09-24 Ajinomoto Co Inc 目的物質の製造法
RU2004124226A (ru) 2004-08-10 2006-01-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) Использование фосфокетолазы для продукции полезных метаболитов
ATE463564T1 (de) * 2004-08-10 2010-04-15 Ajinomoto Kk Verwendung von phosphoketolase zur herstellung geeigneter metabolite
US7205132B2 (en) 2004-09-10 2007-04-17 Ajinomoto Co., Inc. L-glutamic acid-producing microorganism and a method for producing L-glutamic acid
JP4595506B2 (ja) 2004-11-25 2010-12-08 味の素株式会社 Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造方法
US7794989B2 (en) 2004-12-28 2010-09-14 Ajinomoto Co., Inc. L-glutamic acid-producing microorganism and a method for producing L-glutamic acid

Also Published As

Publication number Publication date
BRPI0707229B1 (pt) 2016-12-20
CN101374953B (zh) 2011-09-28
US20100099152A1 (en) 2010-04-22
EP1976995B1 (en) 2010-08-04
US8012722B2 (en) 2011-09-06
PE20071235A1 (es) 2007-12-02
BRPI0707229A2 (pt) 2011-04-26
EP1976995A1 (en) 2008-10-08
CN101374953A (zh) 2009-02-25
WO2007086608A1 (en) 2007-08-02

Similar Documents

Publication Publication Date Title
BRPI0707229B8 (pt) método para produzir um l-aminoácido
BR112015007916A2 (pt) método para produzir l-aminoácido
TR201903336T4 (tr) Fermantasyonda gelişmiş karbon yakalama.
ATE460496T1 (de) Verfahren zur herstellung von l-aminosäure
BRPI0510921A (pt) bactéria produtora de ácido succìnico e processo para produzir ácido succìnico
BRPI1011934A8 (pt) Composição
ECSP14007092A (es) Microorganismos modificados y métodos para elaborar butadieno utilizando los mismos
WO2010093182A3 (ko) Ｌ-아미노산 생산용 미생물 및 이를 이용하여 ｌ-아미노산을 생산하는 방법
BRPI0507717A (pt) microoganismo apresentado uma capacidade de produzir ácido l-glutámico, método para produzir ácido l-glutámico, e, gene
DK2017332T3 (da) Mikroorganisme med evne til at danne L-aminosyre og fremgangsmåde til fremstilling af L-aminosyre
ZA201007237B (en) "mutant microorganism having high ability to produce putrescine and method for producing putrescine using the same"
AR065833A1 (es) Procedimiento para la produccion biologica de 1,3-propanodiol a partir de glicerina con un alto rendimiento
BR112015005416A2 (pt) produção de ácidos orgânicos por meio de fermentação em baixo ph
BR112014006244A2 (pt) microrganismos e métodos para produzir alcenos
ECSP11011056A (es) Composiciones probioticas a base de grano
CL2009001684A1 (es) Procedimiento de sintesis de agomelatina por reduccion de un grupo nitrilo en presencia de anhidrido acetico.
CO6501145A2 (es) Proceso para la síntesis de di- u oligosacaridos de l-fucosilo y nuevos derivados de 2,3,4 tribencil-fucosilo, sus intermediarios
BRPI0907542A2 (pt) Método para produzir ácido 5'-guanílico, e, microrganismo com uma capacidade de converter ácido inosínico em ácido 5'-guanílico
WO2011115439A3 (ko) 5'-크산틸산 및 5'-구아닐산 생산능이 향상된 미생물 및 이를 이용한 5'-크산틸산 또는 5'-구아닐산의 생산방법
EP3502263A3 (en) Method for producing objective substance
BRPI1013673A2 (pt) Microorganismo que produz l-amiácido e método para a produção de l-aminoácido usando o mesmo
MX383967B (es) Microorganismo del género corynebacterium productor de l-arginina y método para producir l-arginina usando el mismo.
CL2012000808A1 (es) Composicion que comprende un caldo o solido de fermentacion con actividad de un actinomiceto que comprenden una proporción optimizada entre las dunaimicinas activas y las dunaimicinas inactivas; proceso para producir un producto de fermentacion enriquecido en dunaimicinas con actividad insecticida; metodo para analizar presencia de una actividad insecticida mejorada en actinomicetos.
BR112016013461A2 (pt) microrganismo corineforme com uma capacidade melhorada para produzir l-lisina, e método para produzir l-lisina
BR112016005456A2 (pt) método para produzir um l-aminoácido por um método de fermentação, e, dna isolado

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 29/01/2007, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]