JPH08500962A - 癌マーカー用生物合成結合蛋白質 - Google Patents

癌マーカー用生物合成結合蛋白質

Info

Publication number
JPH08500962A
JPH08500962A JP5514197A JP51419793A JPH08500962A JP H08500962 A JPH08500962 A JP H08500962A JP 5514197 A JP5514197 A JP 5514197A JP 51419793 A JP51419793 A JP 51419793A JP H08500962 A JPH08500962 A JP H08500962A
Authority
JP
Japan
Prior art keywords
polypeptide
chain
amino acid
erbb
sfv
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP5514197A
Other languages
English (en)
Japanese (ja)
Inventor
エス． ハストン，ジェームズ
ヒューストン，エル．エル．
リング，デイヴィッド，ビー
オパーマン，ハーマン
Original Assignee
クリエイティブ バイオモレキュルズ，インコーポレイテッド
セタス オンコロジー コーポレーション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by クリエイティブ バイオモレキュルズ，インコーポレイテッド, セタス オンコロジー コーポレーション filed Critical クリエイティブ バイオモレキュルズ，インコーポレイテッド
Publication of JPH08500962A publication Critical patent/JPH08500962A/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3015—Breast
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
JP5514197A 1992-02-06 1993-02-05 癌マーカー用生物合成結合蛋白質 Withdrawn JPH08500962A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83196792A 1992-02-06 1992-02-06
US831,967 1992-02-06
PCT/US1993/001055 WO1993016185A2 (en) 1992-02-06 1993-02-05 Biosynthetic binding protein for cancer marker

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2003081465A Division JP4236493B2 (ja) 1992-02-06 2003-03-24 癌マーカー用生物合成結合蛋白質
JP2004178961A Division JP2005104965A (ja) 1992-02-06 2004-06-16 癌マーカー用生物合成結合蛋白質

Publications (1)

Publication Number Publication Date
JPH08500962A true JPH08500962A (ja) 1996-02-06

Family

ID=25260318

Family Applications (8)

Application Number Title Priority Date Filing Date
JP5514197A Withdrawn JPH08500962A (ja) 1992-02-06 1993-02-05 癌マーカー用生物合成結合蛋白質
JP2003081465A Expired - Lifetime JP4236493B2 (ja) 1992-02-06 2003-03-24 癌マーカー用生物合成結合蛋白質
JP2004178961A Withdrawn JP2005104965A (ja) 1992-02-06 2004-06-16 癌マーカー用生物合成結合蛋白質
JP2004260280A Withdrawn JP2005168489A (ja) 1992-02-06 2004-09-07 癌マーカー用生物合成結合蛋白質
JP2007163220A Withdrawn JP2007231027A (ja) 1992-02-06 2007-06-20 癌マーカー用生物合成結合蛋白質
JP2007163221A Withdrawn JP2007228979A (ja) 1992-02-06 2007-06-20 癌マーカー用生物合成結合蛋白質
JP2008209387A Withdrawn JP2008289500A (ja) 1992-02-06 2008-08-15 癌マーカー用生物合成結合蛋白質
JP2008209384A Withdrawn JP2009035558A (ja) 1992-02-06 2008-08-15 癌マーカー用生物合成結合蛋白質

Family Applications After (7)

Application Number Title Priority Date Filing Date
JP2003081465A Expired - Lifetime JP4236493B2 (ja) 1992-02-06 2003-03-24 癌マーカー用生物合成結合蛋白質
JP2004178961A Withdrawn JP2005104965A (ja) 1992-02-06 2004-06-16 癌マーカー用生物合成結合蛋白質
JP2004260280A Withdrawn JP2005168489A (ja) 1992-02-06 2004-09-07 癌マーカー用生物合成結合蛋白質
JP2007163220A Withdrawn JP2007231027A (ja) 1992-02-06 2007-06-20 癌マーカー用生物合成結合蛋白質
JP2007163221A Withdrawn JP2007228979A (ja) 1992-02-06 2007-06-20 癌マーカー用生物合成結合蛋白質
JP2008209387A Withdrawn JP2008289500A (ja) 1992-02-06 2008-08-15 癌マーカー用生物合成結合蛋白質
JP2008209384A Withdrawn JP2009035558A (ja) 1992-02-06 2008-08-15 癌マーカー用生物合成結合蛋白質

Country Status (8)

Country Link
US (6) US5534254A (enExample)
EP (3) EP0625200B1 (enExample)
JP (8) JPH08500962A (enExample)
AT (3) ATE419355T1 (enExample)
AU (1) AU675929B2 (enExample)
CA (2) CA2372813A1 (enExample)
DE (3) DE69334351D1 (enExample)
WO (1) WO1993016185A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007523838A (ja) * 2003-04-14 2007-08-23 アリアス リサーチ、インコーポレイテッド 癌疾患修飾抗体

Families Citing this family (1456)

* Cited by examiner, † Cited by third party
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