SG11201908784TA - Improved antigen binding receptor formats - Google Patents
Improved antigen binding receptor formatsInfo
- Publication number
- SG11201908784TA SG11201908784TA SG11201908784TA SG11201908784TA SG 11201908784T A SG11201908784T A SG 11201908784TA SG 11201908784T A SG11201908784T A SG 11201908784TA SG 11201908784T A SG11201908784T A SG 11201908784TA
- Authority
- SG
- Singapore
- Prior art keywords
- antigen binding
- international
- atm
- roche
- csd
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title abstract 9
- 102000036639 antigens Human genes 0.000 title abstract 9
- 108091007433 antigens Proteins 0.000 title abstract 9
- 230000027455 binding Effects 0.000 title abstract 7
- 239000003795 chemical substances by application Substances 0.000 abstract 6
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 3
- 230000011664 signaling Effects 0.000 abstract 2
- 244000061408 Eugenia caryophyllata Species 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 235000016639 Syzygium aromaticum Nutrition 0.000 abstract 1
- 238000004873 anchoring Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000009870 specific binding Effects 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4631—Chimeric Antigen Receptors [CAR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464424—CD20
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70517—CD8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3007—Carcino-embryonic Antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 04 October 2018 (04.10.2018) WIPO I PCT (51) International Patent Classification: A61K 39/395 (2006.01) C07K 14/735 (2006.01) (71) Applicant all designated States except US): F. HOFF- MANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse A61K 35/17 (2015.01) C07K 16/28 (2006.01) 124, 4070 Basel (CH). C07K 14/725 (2006.01) C07K 16/30 (2006.01) C07K 14/705 (2006.01) A61K 39/00 (2006.01) (71) Applicant (for US only): HOFFMANN-LA ROCHE (21) International Application Number: INC. [US/US]; Overlook at Great Notch, 150 Clove Road, 8th Floor, Suite 8 - Legal Department, Little Falls, New Jer- PCT/EP2018/057567 sey 07424 (US). omit VIII °nolo olo VIII lII 1111111 ow (10) International Publication Number WO 2018/177967 Al (22) International Filing Date: 26 March 2018 (26.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 17163090.8 27 March 2017 (27.03.2017) EP 17171775.4 18 May 2017 (18.05.2017) EP (72) Inventors: KLEIN, Christian; c/o Roche Glycart AG, Wagistrasse 18, 8952 Schlieren (CH). MOESSNER, Ekke- hard; c/o Roche Glycart AG, Wagistrasse 18, 8952 Sch- lieren (CH). DAROWSKI, Diana; c/o Roche Glycart AG, Wagistrasse 18, 8952 Schlieren (CH). STUBENRAUCH, Kay-Gunnar; c/o Roche Diagnostics GmbH, Nonnenwald 2, 82377 Penzberg (DE). (74) Agent: BRODBECK, Michel; Grenzacherstrasse 124, 4070 Basel (CH). (54) Title: IMPROVED ANTIGEN BINDING RECEPTOR FORMATS Figure 1A Figure 1B Figure 1C linker VL CL linker VH VH CH CH VH CH ATM CSD SSD VL CL VL CL ATM CSD SSD ATM CSD SSD 1-1 N 1-1 00 1-1 O Fab Format Fab Format VL-CL-ATM scFab Format ATM = anchoring transmembrane domain; CSD = co-stimulatory signaling domain ; SSD = stimulatory signaling domain (57) : The present disclosure generally relates to antigen binding receptors in new formats capable of specific binding to a tumor associated antigen. More precisely, the present invention relates to an antigen binding receptor which efficiently and specifically binds to/interacts with an antigen on the surface of a tumor cell, and to a T cell transfected/transduced with the antigen binding receptor. Furthermore, the invention relates to nucleic acid molecules and vectors encoding antigen binding receptors of the present invention. The invention also provides the production and use of T cells in a method for the treatment of particular diseases as well as pharmaceutical compositions/medicaments comprising antigen binding receptors and/or T cells of the present invention. [Continued on next page] WO 2018/177967 Al IMEDIMOMMIONE1013010BEHOHNEMOVOIMIE (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a))
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP17163090 | 2017-03-27 | ||
EP17171775 | 2017-05-18 | ||
PCT/EP2018/057567 WO2018177967A1 (en) | 2017-03-27 | 2018-03-26 | Improved antigen binding receptor formats |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201908784TA true SG11201908784TA (en) | 2019-10-30 |
Family
ID=61800534
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201908784T SG11201908784TA (en) | 2017-03-27 | 2018-03-26 | Improved antigen binding receptor formats |
Country Status (19)
Country | Link |
---|---|
US (1) | US20200093861A1 (en) |
EP (1) | EP3600408A1 (en) |
JP (1) | JP2020511979A (en) |
KR (1) | KR20190133017A (en) |
CN (1) | CN110461360A (en) |
AU (1) | AU2018241625A1 (en) |
BR (1) | BR112019017629A2 (en) |
CA (1) | CA3054104A1 (en) |
CL (1) | CL2019002686A1 (en) |
CR (1) | CR20190431A (en) |
IL (1) | IL268824A (en) |
MA (1) | MA49355A (en) |
MX (1) | MX2019011656A (en) |
PE (1) | PE20191703A1 (en) |
RU (1) | RU2019133199A (en) |
SG (1) | SG11201908784TA (en) |
TW (1) | TW201900672A (en) |
WO (1) | WO2018177967A1 (en) |
ZA (1) | ZA201905519B (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
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AR106188A1 (en) | 2015-10-01 | 2017-12-20 | Hoffmann La Roche | ANTI-CD19 HUMANIZED HUMAN ANTIBODIES AND METHODS OF USE |
JP7022123B2 (en) * | 2016-09-30 | 2022-02-17 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | Bispecific antibody against CD3 |
CN108395482B (en) | 2017-02-08 | 2021-02-05 | 西比曼生物科技(香港)有限公司 | Construction of targeting CD20 antigen chimeric antigen receptor and activity identification of engineered T cell thereof |
RU2019133202A (en) | 2017-03-27 | 2021-04-28 | Ф. Хоффманн-Ля Рош Аг | IMPROVED ANTIGEN BINDING RECEPTORS |
US20200223925A1 (en) * | 2018-12-21 | 2020-07-16 | Hoffmann-La Roche Inc. | Tumor-targeted superagonistic cd28 antigen binding molecules |
MA54513A (en) * | 2018-12-21 | 2022-03-30 | Hoffmann La Roche | CD28 ANTIGEN BINDING MOLECULES TUMOR TARGETING AGONISTS |
CN110317277A (en) * | 2019-07-10 | 2019-10-11 | 杭州普科亭生物医药有限公司 | Chimeric antigen receptor and its application |
TW202142570A (en) * | 2020-04-30 | 2021-11-16 | 大陸商正大天晴藥業集團股份有限公司 | Antigen binding constructs targeting her2 and uses thereof |
WO2022040454A1 (en) | 2020-08-20 | 2022-02-24 | A2 Biotherapeutics, Inc. | Compositions and methods for treating mesothelin positive cancers |
CA3188867A1 (en) * | 2020-08-20 | 2022-02-24 | Xueyin Wang | Compositions and methods for treating ceacam positive cancers |
CN114990129B (en) * | 2022-05-11 | 2023-02-03 | 北京贝来生物科技有限公司 | Preparation and application of mesenchymal stem cells expressing alpha PDL1: fc fusion protein |
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UA117289C2 (en) | 2014-04-02 | 2018-07-10 | Ф. Хоффманн-Ля Рош Аг | Multispecific antibodies |
WO2015179833A1 (en) * | 2014-05-23 | 2015-11-26 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treating antibody resistance |
SG11201610170SA (en) * | 2014-06-06 | 2017-01-27 | Bluebird Bio Inc | Improved t cell compositions |
PE20211533A1 (en) | 2014-08-04 | 2021-08-16 | Hoffmann La Roche | BISPECIFIC MOLECULES OF UNON TO ANTIGEN ACTIVATING T-CELLS |
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WO2016126608A1 (en) * | 2015-02-02 | 2016-08-11 | Novartis Ag | Car-expressing cells against multiple tumor antigens and uses thereof |
US9574014B2 (en) | 2015-05-15 | 2017-02-21 | City Of Hope | Chimeric antigen receptor compositions |
EP3344262A4 (en) * | 2015-09-01 | 2019-03-20 | Innate Tumor Immunity, Inc. | Immune cells having increased immunity or resistance to an immunosuppressive cytokine and use of the same |
EP3356418A4 (en) * | 2015-10-01 | 2019-07-03 | The Centre for Drug Research and Development | Anti-podocalyxin antibodies and methods of using the same |
EP3529279A4 (en) * | 2016-10-19 | 2020-04-29 | The Governing Council of the University of Toronto | Cd133-binding agents and uses thereof |
JOP20180027A1 (en) * | 2017-03-28 | 2019-01-30 | Cell Design Labs Inc | Chimeric polypeptides and methods of altering the membrane localization of the same |
-
2018
- 2018-03-26 EP EP18713648.6A patent/EP3600408A1/en not_active Withdrawn
- 2018-03-26 TW TW107110206A patent/TW201900672A/en unknown
- 2018-03-26 CA CA3054104A patent/CA3054104A1/en active Pending
- 2018-03-26 BR BR112019017629A patent/BR112019017629A2/en unknown
- 2018-03-26 CR CR20190431A patent/CR20190431A/en unknown
- 2018-03-26 SG SG11201908784T patent/SG11201908784TA/en unknown
- 2018-03-26 AU AU2018241625A patent/AU2018241625A1/en not_active Abandoned
- 2018-03-26 JP JP2019552992A patent/JP2020511979A/en active Pending
- 2018-03-26 PE PE2019001939A patent/PE20191703A1/en unknown
- 2018-03-26 CN CN201880021542.3A patent/CN110461360A/en active Pending
- 2018-03-26 MA MA049355A patent/MA49355A/en unknown
- 2018-03-26 MX MX2019011656A patent/MX2019011656A/en unknown
- 2018-03-26 WO PCT/EP2018/057567 patent/WO2018177967A1/en unknown
- 2018-03-26 KR KR1020197030317A patent/KR20190133017A/en not_active Application Discontinuation
- 2018-03-26 RU RU2019133199A patent/RU2019133199A/en unknown
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2019
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- 2019-08-21 ZA ZA2019/05519A patent/ZA201905519B/en unknown
- 2019-09-19 US US16/576,586 patent/US20200093861A1/en not_active Abandoned
- 2019-09-23 CL CL2019002686A patent/CL2019002686A1/en unknown
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JP2020511979A (en) | 2020-04-23 |
KR20190133017A (en) | 2019-11-29 |
CA3054104A1 (en) | 2018-10-04 |
RU2019133199A (en) | 2021-04-28 |
MX2019011656A (en) | 2019-12-02 |
ZA201905519B (en) | 2021-06-30 |
TW201900672A (en) | 2019-01-01 |
AU2018241625A1 (en) | 2019-09-05 |
WO2018177967A1 (en) | 2018-10-04 |
PE20191703A1 (en) | 2019-11-27 |
CL2019002686A1 (en) | 2020-02-14 |
CN110461360A (en) | 2019-11-15 |
US20200093861A1 (en) | 2020-03-26 |
MA49355A (en) | 2020-02-05 |
BR112019017629A2 (en) | 2020-04-07 |
EP3600408A1 (en) | 2020-02-05 |
CR20190431A (en) | 2019-11-01 |
IL268824A (en) | 2019-10-31 |
RU2019133199A3 (en) | 2021-07-09 |
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