SG11201804398XA - Method for producing rna molecule compositions - Google Patents
Method for producing rna molecule compositionsInfo
- Publication number
- SG11201804398XA SG11201804398XA SG11201804398XA SG11201804398XA SG11201804398XA SG 11201804398X A SG11201804398X A SG 11201804398XA SG 11201804398X A SG11201804398X A SG 11201804398XA SG 11201804398X A SG11201804398X A SG 11201804398XA SG 11201804398X A SG11201804398X A SG 11201804398XA
- Authority
- SG
- Singapore
- Prior art keywords
- rna
- international
- composition
- tubingen
- iii
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
- C12N15/1024—In vivo mutagenesis using high mutation rate "mutator" host strains by inserting genetic material, e.g. encoding an error prone polymerase, disrupting a gene for mismatch repair
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
- C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2521/00—Reaction characterised by the enzymatic activity
- C12Q2521/10—Nucleotidyl transfering
- C12Q2521/119—RNA polymerase
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B10/00—Directed molecular evolution of macromolecules, e.g. RNA, DNA or proteins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 29 June 2017 (29.06.2017) WIPOIPCT (10) International Publication Number WO 2017/109134 A1 (51) International Patent Classification: A61K38/00 (2006.01) A61K 48/00 (2006.01) A61K39/00 (2006.01) (21) International Application Number: PCT/EP2016/082487 (22) International Filing Date: (25) Filing Language: (26) Publication Language (30) Priority Data: PCT/EP2015/081000 22 December 2016 (22.12.2016) English English 22 December 2015 (22.12.2015) EP (71) Applicant: CUREVAC AG [DE/DE]; Paul-Ehrlich-Str. 15, 72076 Tubingen (DE). (72) Inventors: ROOS, Tilmann; Kirchentellinsfurter Strasse 16, 72127 Kusterdingen (DE). KUNZE, Martin; Gelber Kreidebusen 31, 72108 Rottenburg (DE). YAZDAN PA- NAH, Benyamin; Goethestrasse 11, 72076 Tubingen (DE). YILMAZ, Salih; Untere Hohbergstr. 18, 72074 Tubingen (DE). CONZELMANN, Markus; Steinlach- allee 24, 72072 Tubingen (DE). (74) Agent: MAIWALD PATENTANWALTS GMBH; Dr. Andrea Lasar, Elisenhof, Elisenstrasse 3, 80335 Munich (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). [Continued on next page] (54) Title: METHOD FOR PRODUCING RNA MOLECULE COMPOSITIONS Figure 6 I < Tf WMMMMiMI ON t $ r <? (57) : The invention relates to a method for producing ribonucleic acid a (RNA) molecule composition compris ing n different RNA molecule species, the method comprising step of RNA a in vitro transcription of mixture of a m dif ferent deoxyribonucleic acid (DNA) molecule species in a single reaction vessel in parallel, i.e. simultaneously, and a step of obtaining the RNA mo lecule composition. Also provided is the RNA composition provided by the in ventive method and a pharmaceutical composition comprising the same as well as a pharmaceutical container. Moreover, the invention provides the RNA composition and the pharmaceut ical composition for use as medicament. WO 2017/109134 A11II llll IIII III III Hill III III III 111 Hill lllll llll 111 llll mill llll 111 III Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a))
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP2015081000 | 2015-12-22 | ||
PCT/EP2016/082487 WO2017109134A1 (en) | 2015-12-22 | 2016-12-22 | Method for producing rna molecule compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201804398XA true SG11201804398XA (en) | 2018-07-30 |
Family
ID=55080091
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201804398XA SG11201804398XA (en) | 2015-12-22 | 2016-12-22 | Method for producing rna molecule compositions |
Country Status (11)
Country | Link |
---|---|
US (2) | US11684665B2 (en) |
EP (2) | EP3319622B1 (en) |
JP (1) | JP6949845B2 (en) |
KR (1) | KR20180107109A (en) |
CN (1) | CN108778308A (en) |
AU (1) | AU2016375021B2 (en) |
CA (1) | CA3009551C (en) |
DK (1) | DK3319622T3 (en) |
IL (1) | IL259378A (en) |
SG (1) | SG11201804398XA (en) |
WO (1) | WO2017109134A1 (en) |
Families Citing this family (110)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2807942C (en) | 2010-08-10 | 2021-07-27 | Ecole Polytechnique Federale De Lausanne | Erythrocyte-binding therapeutics |
US9517257B2 (en) | 2010-08-10 | 2016-12-13 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
US9850296B2 (en) | 2010-08-10 | 2017-12-26 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
EP2717893B1 (en) | 2011-06-08 | 2019-05-08 | Translate Bio, Inc. | Lipid nanoparticle compositions and methods for mrna delivery |
US10323236B2 (en) | 2011-07-22 | 2019-06-18 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
DK2958588T3 (en) | 2013-02-22 | 2017-11-20 | Curevac Ag | Combination of vaccination and inhibition of PD-1 pathway |
EP3757570B1 (en) | 2013-03-15 | 2023-10-11 | Translate Bio, Inc. | Synergistic enhancement of the delivery of nucleic acids via blended formulations |
US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
KR20160044566A (en) | 2013-08-21 | 2016-04-25 | 큐어백 아게 | Respiratory syncytial virus (RSV) vaccine |
US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
US9737604B2 (en) | 2013-09-06 | 2017-08-22 | President And Fellows Of Harvard College | Use of cationic lipids to deliver CAS9 |
US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
US9068179B1 (en) | 2013-12-12 | 2015-06-30 | President And Fellows Of Harvard College | Methods for correcting presenilin point mutations |
US10046056B2 (en) | 2014-02-21 | 2018-08-14 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
US10953101B2 (en) | 2014-02-21 | 2021-03-23 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
US10946079B2 (en) | 2014-02-21 | 2021-03-16 | Ecole Polytechnique Federale De Lausanne | Glycotargeting therapeutics |
SG10202010936RA (en) | 2014-02-21 | 2020-12-30 | Ecole Polytecnique Fed De Lausanne Epfl Epfl Tto | Glycotargeting therapeutics |
AU2015298571B2 (en) | 2014-07-30 | 2020-09-03 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
EP3708668B1 (en) | 2014-12-12 | 2022-07-27 | CureVac AG | Artificial nucleic acid molecules for improved protein expression |
EP3283125B1 (en) | 2015-04-17 | 2021-12-29 | CureVac Real Estate GmbH | Lyophilization of rna |
DK3294885T3 (en) | 2015-05-08 | 2020-08-10 | Curevac Real Estate Gmbh | METHOD OF PREPARING RNA |
SG11201708540VA (en) | 2015-05-20 | 2017-12-28 | Curevac Ag | Dry powder composition comprising long-chain rna |
CN107530448A (en) | 2015-05-20 | 2018-01-02 | 库瑞瓦格股份公司 | Include long-chain RNA dry powder composite |
DE22190069T1 (en) | 2015-05-29 | 2023-03-02 | Curevac Real Estate Gmbh | PROCESS FOR RNA PREPARATION AND PURIFICATION WITH AT LEAST ONE TANGENTIAL FLOW FILTRATION STEP |
US11608513B2 (en) | 2015-05-29 | 2023-03-21 | CureVac SE | Method for adding cap structures to RNA using immobilized enzymes |
US11225682B2 (en) | 2015-10-12 | 2022-01-18 | Curevac Ag | Automated method for isolation, selection and/or detection of microorganisms or cells comprised in a solution |
IL258821B (en) | 2015-10-23 | 2022-07-01 | Harvard College | Nucleobase editors and uses thereof |
WO2017081110A1 (en) | 2015-11-09 | 2017-05-18 | Curevac Ag | Rotavirus vaccines |
SG11201804398XA (en) | 2015-12-22 | 2018-07-30 | Curevac Ag | Method for producing rna molecule compositions |
EP3394280A1 (en) | 2015-12-23 | 2018-10-31 | CureVac AG | Method of rna in vitro transcription using a buffer containing a dicarboxylic acid or tricarboxylic acid or a salt thereof |
SG11201806340YA (en) | 2016-02-17 | 2018-09-27 | Curevac Ag | Zika virus vaccine |
US11920174B2 (en) | 2016-03-03 | 2024-03-05 | CureVac SE | RNA analysis by total hydrolysis and quantification of released nucleosides |
WO2017177169A1 (en) | 2016-04-08 | 2017-10-12 | Rana Therapeutics, Inc. | Multimeric coding nucleic acid and uses thereof |
WO2017186928A1 (en) | 2016-04-29 | 2017-11-02 | Curevac Ag | Rna encoding an antibody |
WO2017191264A1 (en) | 2016-05-04 | 2017-11-09 | Curevac Ag | Nucleic acid molecules and uses thereof |
WO2017191274A2 (en) | 2016-05-04 | 2017-11-09 | Curevac Ag | Rna encoding a therapeutic protein |
EP3468613A1 (en) | 2016-06-09 | 2019-04-17 | CureVac AG | Hybrid carriers for nucleic acid cargo |
JP2019522047A (en) | 2016-06-13 | 2019-08-08 | トランスレイト バイオ, インコーポレイテッド | Messenger RNA therapy for the treatment of ornithine transcarbamylase deficiency |
IL264565B1 (en) | 2016-08-03 | 2024-03-01 | Harvard College | Adenosine nucleobase editors and uses thereof |
CA3033327A1 (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
JP2019530464A (en) | 2016-10-14 | 2019-10-24 | プレジデント アンド フェローズ オブ ハーバード カレッジ | Nucleobase editor AAV delivery |
WO2018096179A1 (en) | 2016-11-28 | 2018-05-31 | Curevac Ag | Method for purifying rna |
WO2018104540A1 (en) | 2016-12-08 | 2018-06-14 | Curevac Ag | Rnas for wound healing |
EP3808380A1 (en) | 2016-12-08 | 2021-04-21 | CureVac AG | Rna for treatment or prophylaxis of a liver disease |
EP3558354A1 (en) | 2016-12-23 | 2019-10-30 | CureVac AG | Lassa virus vaccine |
US11141476B2 (en) | 2016-12-23 | 2021-10-12 | Curevac Ag | MERS coronavirus vaccine |
US10745677B2 (en) | 2016-12-23 | 2020-08-18 | President And Fellows Of Harvard College | Editing of CCR5 receptor gene to protect against HIV infection |
US11524066B2 (en) | 2016-12-23 | 2022-12-13 | CureVac SE | Henipavirus vaccine |
US11898179B2 (en) | 2017-03-09 | 2024-02-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
CN110914310A (en) | 2017-03-10 | 2020-03-24 | 哈佛大学的校长及成员们 | Cytosine to guanine base editor |
CN110392577A (en) | 2017-03-17 | 2019-10-29 | 库尔维科公司 | For combining the RNA vaccine and immunologic test point inhibitor of anti-cancer therapies |
WO2018176009A1 (en) | 2017-03-23 | 2018-09-27 | President And Fellows Of Harvard College | Nucleobase editors comprising nucleic acid programmable dna binding proteins |
CN110914433A (en) | 2017-03-24 | 2020-03-24 | 库尔维科公司 | Nucleic acids encoding CRISPR-associated proteins and uses thereof |
US11357856B2 (en) | 2017-04-13 | 2022-06-14 | Acuitas Therapeutics, Inc. | Lipids for delivery of active agents |
US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
WO2018232176A1 (en) | 2017-06-16 | 2018-12-20 | The University Of Chicago | Compositions and methods for inducing immune tolerance |
US10988754B2 (en) | 2017-07-04 | 2021-04-27 | Cure Vac AG | Nucleic acid molecules |
WO2019023680A1 (en) | 2017-07-28 | 2019-01-31 | President And Fellows Of Harvard College | Methods and compositions for evolving base editors using phage-assisted continuous evolution (pace) |
US11602557B2 (en) | 2017-08-22 | 2023-03-14 | Cure Vac SE | Bunyavirales vaccine |
WO2019139645A2 (en) | 2017-08-30 | 2019-07-18 | President And Fellows Of Harvard College | High efficiency base editors comprising gam |
WO2019079347A1 (en) | 2017-10-16 | 2019-04-25 | The Broad Institute, Inc. | Uses of adenosine base editors |
CA3073634A1 (en) | 2017-10-19 | 2019-04-25 | Curevac Ag | Novel artificial nucleic acid molecules |
US11692002B2 (en) | 2017-11-08 | 2023-07-04 | CureVac SE | RNA sequence adaptation |
EP3723796A1 (en) | 2017-12-13 | 2020-10-21 | CureVac AG | Flavivirus vaccine |
WO2019126593A1 (en) | 2017-12-20 | 2019-06-27 | Translate Bio, Inc. | Improved composition and methods for treatment of ornithine transcarbamylase deficiency |
SG11202005760PA (en) | 2017-12-21 | 2020-07-29 | Curevac Ag | Linear double stranded dna coupled to a single support or a tag and methods for producing said linear double stranded dna |
EP3773702A2 (en) | 2018-04-05 | 2021-02-17 | CureVac AG | Novel yellow fever nucleic acid molecules for vaccination |
BR112020020933A2 (en) | 2018-04-17 | 2021-04-06 | Curevac Ag | INNOVATIVE RSV RNA MOLECULES AND VACCINATION COMPOSITIONS |
CN108611310A (en) * | 2018-04-28 | 2018-10-02 | 中国药科大学 | A kind of recombination Hsp65 and STEAP1186-193The structure of the genetic engineering bacterium of fusion protein |
US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
EP3813874A1 (en) | 2018-06-27 | 2021-05-05 | CureVac AG | Novel lassa virus rna molecules and compositions for vaccination |
US20210261897A1 (en) | 2018-06-28 | 2021-08-26 | Curevac Ag | Bioreactor for rna in vitro transcription |
CN109453392A (en) * | 2018-10-18 | 2019-03-12 | 杭州功楚生物科技有限公司 | Line interactions between protein protein inhibitor and its purposes in the preparation of antitumor drugs |
WO2020092880A1 (en) * | 2018-11-02 | 2020-05-07 | The Wistar Institute Of Anatomy And Biology | A novel dna vaccine against crimean-congo hemorrhagic fever virus (cchfv) |
EP3897702A2 (en) | 2018-12-21 | 2021-10-27 | CureVac AG | Rna for malaria vaccines |
CN109771432B (en) * | 2019-03-13 | 2022-04-19 | 中国人民解放军军事科学院军事医学研究院 | Application of glucosamine and derivatives thereof as antiviral drugs |
WO2020191239A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
CN110106238A (en) * | 2019-05-17 | 2019-08-09 | 北京康旭医学检验所有限公司 | It is a kind of for detecting the double PCR molecule diagnosis kit of x chromosome inactivation |
US20220313813A1 (en) | 2019-06-18 | 2022-10-06 | Curevac Ag | Rotavirus mrna vaccine |
MX2022001468A (en) | 2019-08-09 | 2022-07-19 | Nutcracker Therapeutics Inc | Methods and apparatuses for manufacturing for removing material from a therapeutic composition. |
CN110898216B (en) * | 2019-12-31 | 2021-12-03 | 中国农业科学院兰州兽医研究所 | Application of recombinant trichina thioredoxin peroxidase 2 in preparation of vaccine for resisting trichina infection |
US11241493B2 (en) | 2020-02-04 | 2022-02-08 | Curevac Ag | Coronavirus vaccine |
US11576966B2 (en) | 2020-02-04 | 2023-02-14 | CureVac SE | Coronavirus vaccine |
IL293571A (en) | 2020-02-04 | 2022-08-01 | Curevac Ag | Coronavirus vaccine |
WO2021207031A1 (en) * | 2020-04-05 | 2021-10-14 | Coagulo Medical Technologies, Inc. | Methods of treating and preventing coronavirus infections using inhibitors of coagulation factor xa |
WO2021205077A1 (en) | 2020-04-09 | 2021-10-14 | Finncure Oy | Mimetic nanoparticles for preventing the spreading and lowering the infection rate of novel coronaviruses |
CN111471635B (en) * | 2020-04-13 | 2022-02-15 | 江南大学 | Method for increasing content of nucleic acid in bacillus subtilis |
DE112021002672T5 (en) | 2020-05-08 | 2023-04-13 | President And Fellows Of Harvard College | METHODS AND COMPOSITIONS FOR EDIT BOTH STRANDS SIMULTANEOUSLY OF A DOUBLE STRANDED NUCLEOTIDE TARGET SEQUENCE |
BR112022024248A2 (en) | 2020-05-29 | 2023-10-10 | CureVac SE | NUCLEIC ACID-BASED COMBINATION VACCINES |
EP4165205A1 (en) | 2020-06-15 | 2023-04-19 | CureVac SE | Analysis of nucleic acid mixtures |
CN111621525B (en) * | 2020-06-18 | 2021-04-23 | 中赛干细胞基因工程有限公司 | Application of STX1B gene in promoting growth and differentiation of human adipose-derived mesenchymal stem cells |
US20230272052A1 (en) | 2020-07-31 | 2023-08-31 | CureVac SE | Nucleic acid encoded antibody mixtures |
CN111944894B (en) * | 2020-08-24 | 2023-01-17 | 中国医科大学附属盛京医院 | Molecular marker for prenatal noninvasive diagnosis of cleft lip and palate, neural tube malformation and congenital heart disease and application thereof |
WO2022043551A2 (en) | 2020-08-31 | 2022-03-03 | Curevac Ag | Multivalent nucleic acid based coronavirus vaccines |
CN111978382B (en) * | 2020-09-03 | 2022-03-04 | 吉林大学第一医院 | Preparation method and application of recombinant protein of Sporothrix globosum Gp70 |
CN112094329B (en) * | 2020-09-30 | 2022-10-18 | 四川大学 | Lipoprotein transport inhibitor, application thereof and antibacterial drug |
EP4203997A1 (en) | 2020-10-26 | 2023-07-05 | Pécsi Tudományegyetem | Vaccine platform |
WO2022106860A1 (en) | 2020-11-20 | 2022-05-27 | Pécsi Tudományegyetem | Recombinant peptides for use in therapy |
WO2022137133A1 (en) | 2020-12-22 | 2022-06-30 | Curevac Ag | Rna vaccine against sars-cov-2 variants |
BR112023012303A2 (en) | 2020-12-22 | 2024-02-15 | CureVac SE | RNA VACCINE AGAINST SARS-COV-2 VARIANTS |
US11175293B1 (en) | 2021-01-04 | 2021-11-16 | University Of Utah Research Foundation | Rapid assay for detection of SARS-CoV-2 antibodies |
KR102561980B1 (en) * | 2021-03-16 | 2023-08-01 | 한양대학교 에리카산학협력단 | Pharmaceutical composition for preventing or treating inflammatory diseases comprising Toxoplasma gondii GRA9 protein or gene thereof as an active ingredient |
CN113046452B (en) * | 2021-03-23 | 2022-02-25 | 中国人民解放军陆军军医大学 | Composition for detecting Boeck hollandia farci and application thereof |
JP2024511206A (en) | 2021-03-26 | 2024-03-12 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | immunogenic composition |
WO2023182846A1 (en) * | 2022-03-23 | 2023-09-28 | 한국과학기술원 | Use of thbs1 inhibitor for overcoming drug resistance in cancer |
TW202400251A (en) * | 2022-04-27 | 2024-01-01 | 大陸商瑞可迪(上海)生物醫藥有限公司 | Nucleic acid constructs and applications thereof |
EP4293101A1 (en) * | 2022-06-14 | 2023-12-20 | Asklepios Biopharmaceutical, Inc. | Reactor with temperature control and method of using the same |
WO2024068545A1 (en) | 2022-09-26 | 2024-04-04 | Glaxosmithkline Biologicals Sa | Influenza virus vaccines |
Family Cites Families (120)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69923840T2 (en) * | 1999-09-09 | 2006-04-06 | Curevac Gmbh | Transfer of mRNAs using polycationic compounds |
EP1392341B1 (en) | 2001-06-05 | 2005-03-30 | Curevac GmbH | Pharmaceutical composition containing a stabilised mrna which is optimised for translation in the coding regions thereof |
DE10162480A1 (en) | 2001-12-19 | 2003-08-07 | Ingmar Hoerr | The application of mRNA for use as a therapeutic agent against tumor diseases |
DE10229872A1 (en) | 2002-07-03 | 2004-01-29 | Curevac Gmbh | Immune stimulation through chemically modified RNA |
DE10335833A1 (en) | 2003-08-05 | 2005-03-03 | Curevac Gmbh | Transfection of blood cells with mRNA for immune stimulation and gene therapy |
DE102004042546A1 (en) | 2004-09-02 | 2006-03-09 | Curevac Gmbh | Combination therapy for immune stimulation |
DE102005023170A1 (en) | 2005-05-19 | 2006-11-23 | Curevac Gmbh | Optimized formulation for mRNA |
DE102006035618A1 (en) | 2006-07-31 | 2008-02-07 | Curevac Gmbh | New nucleic acid useful as immuno-stimulating adjuvant for manufacture of a composition for treatment of cancer diseases e.g. colon carcinomas and infectious diseases e.g. influenza and malaria |
DE102006061015A1 (en) | 2006-12-22 | 2008-06-26 | Curevac Gmbh | Process for the purification of RNA on a preparative scale by HPLC |
DE102007001370A1 (en) | 2007-01-09 | 2008-07-10 | Curevac Gmbh | RNA-encoded antibodies |
WO2009030254A1 (en) | 2007-09-04 | 2009-03-12 | Curevac Gmbh | Complexes of rna and cationic peptides for transfection and for immunostimulation |
WO2009046739A1 (en) | 2007-10-09 | 2009-04-16 | Curevac Gmbh | Composition for treating prostate cancer (pca) |
WO2009046738A1 (en) | 2007-10-09 | 2009-04-16 | Curevac Gmbh | Composition for treating lung cancer, particularly of non-small lung cancers (nsclc) |
HUE025027T2 (en) | 2008-01-31 | 2016-07-28 | Curevac Gmbh | NUCLEIC ACIDS COMPRISING FORMULA (NuGiXmGnNv)a AND DERIVATIVES THEREOF AS AN IMMUNOSTIMULATING AGENTS /ADJUVANTS |
WO2010037408A1 (en) * | 2008-09-30 | 2010-04-08 | Curevac Gmbh | Composition comprising a complexed (m)rna and a naked mrna for providing or enhancing an immunostimulatory response in a mammal and uses thereof |
GB0901593D0 (en) | 2009-01-30 | 2009-03-11 | Touchlight Genetics Ltd | Production of closed linear DNA |
US20110053829A1 (en) | 2009-09-03 | 2011-03-03 | Curevac Gmbh | Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids |
WO2011069529A1 (en) | 2009-12-09 | 2011-06-16 | Curevac Gmbh | Mannose-containing solution for lyophilization, transfection and/or injection of nucleic acids |
BR112013002298A2 (en) | 2010-07-30 | 2016-05-24 | Curevac Gmbh | nucleic acid complexation with disulfide crosslinked cationic components for transfection and immune stimulation. |
WO2012019630A1 (en) | 2010-08-13 | 2012-02-16 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded protein |
WO2012089225A1 (en) | 2010-12-29 | 2012-07-05 | Curevac Gmbh | Combination of vaccination and inhibition of mhc class i restricted antigen presentation |
WO2012116715A1 (en) | 2011-03-02 | 2012-09-07 | Curevac Gmbh | Vaccination in newborns and infants |
WO2012113413A1 (en) | 2011-02-21 | 2012-08-30 | Curevac Gmbh | Vaccine composition comprising complexed immunostimulatory nucleic acids and antigens packaged with disulfide-linked polyethyleneglycol/peptide conjugates |
WO2012116714A1 (en) | 2011-03-02 | 2012-09-07 | Curevac Gmbh | Vaccination in elderly patients |
EP2623121A1 (en) | 2012-01-31 | 2013-08-07 | Bayer Innovation GmbH | Pharmaceutical composition comprising a polymeric carrier cargo complex and an antigen |
WO2013113326A1 (en) | 2012-01-31 | 2013-08-08 | Curevac Gmbh | Pharmaceutical composition comprising a polymeric carrier cargo complex and at least one protein or peptide antigen |
WO2013113325A1 (en) | 2012-01-31 | 2013-08-08 | Curevac Gmbh | Negatively charged nucleic acid comprising complexes for immunostimulation |
WO2013120498A1 (en) | 2012-02-15 | 2013-08-22 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded allergenic antigen or an autoimmune self-antigen |
WO2013120499A1 (en) | 2012-02-15 | 2013-08-22 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly (a) sequence or a polyadenylation signal for increasing the expression of an encoded pathogenic antigen |
WO2013120497A1 (en) | 2012-02-15 | 2013-08-22 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded therapeutic protein |
WO2013120500A1 (en) | 2012-02-15 | 2013-08-22 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded tumour antigen |
ES2654205T3 (en) | 2012-03-27 | 2018-02-12 | Curevac Ag | Artificial nucleic acid molecules for enhanced protein or peptide expression |
CN108929880A (en) | 2012-03-27 | 2018-12-04 | 库瑞瓦格股份公司 | Artificial nucleic acid molecule comprising 5 ' TOPUTR |
AU2013242403B2 (en) | 2012-03-27 | 2018-10-18 | Curevac Ag | Artificial nucleic acid molecules |
EP2854857B1 (en) | 2012-05-25 | 2018-11-28 | CureVac AG | Reversible immobilization and/or controlled release of nucleic acid containing nanoparticles by (biodegradable) polymer coatings |
DK2958588T3 (en) | 2013-02-22 | 2017-11-20 | Curevac Ag | Combination of vaccination and inhibition of PD-1 pathway |
WO2014144039A1 (en) | 2013-03-15 | 2014-09-18 | Moderna Therapeutics, Inc. | Characterization of mrna molecules |
SG10201801429VA (en) | 2013-08-21 | 2018-03-28 | Curevac Ag | Composition and vaccine for treating lung cancer |
CN105473157A (en) | 2013-08-21 | 2016-04-06 | 库瑞瓦格股份公司 | Combination vaccine |
KR20160044566A (en) | 2013-08-21 | 2016-04-25 | 큐어백 아게 | Respiratory syncytial virus (RSV) vaccine |
MX2016002153A (en) | 2013-08-21 | 2017-03-01 | Curevac Ag | Composition and vaccine for treating prostate cancer. |
ES2702466T3 (en) | 2013-08-21 | 2019-03-01 | Curevac Ag | Procedure to increase the expression of proteins encoded by RNA |
WO2015024665A1 (en) | 2013-08-21 | 2015-02-26 | Curevac Gmbh | Rabies vaccine |
CA2925658C (en) * | 2013-10-01 | 2022-12-06 | Mie University | Long chain antigen containing interepitope sequence that promotes antigen presentation to t cells |
WO2015062738A1 (en) | 2013-11-01 | 2015-05-07 | Curevac Gmbh | Modified rna with decreased immunostimulatory properties |
BR112016014462A2 (en) | 2013-12-30 | 2017-10-24 | Curevac Ag | artificial nucleic acid molecules |
WO2015101415A1 (en) | 2013-12-30 | 2015-07-09 | Curevac Gmbh | Artificial nucleic acid molecules |
SG11201604198YA (en) | 2013-12-30 | 2016-07-28 | Curevac Ag | Methods for rna analysis |
US10307472B2 (en) | 2014-03-12 | 2019-06-04 | Curevac Ag | Combination of vaccination and OX40 agonists |
EP3129050A2 (en) | 2014-04-01 | 2017-02-15 | CureVac AG | Polymeric carrier cargo complex for use as an immunostimulating agent or as an adjuvant |
BR112016026980B1 (en) | 2014-06-10 | 2022-05-03 | Curevac Real Estate Gmbh | Method for synthesizing an RNA molecule of a given sequence |
EP3708668B1 (en) | 2014-12-12 | 2022-07-27 | CureVac AG | Artificial nucleic acid molecules for improved protein expression |
WO2016097065A1 (en) | 2014-12-16 | 2016-06-23 | Curevac Ag | Ebolavirus and marburgvirus vaccines |
EP3240558A1 (en) | 2014-12-30 | 2017-11-08 | CureVac AG | Artificial nucleic acid molecules |
US10653768B2 (en) | 2015-04-13 | 2020-05-19 | Curevac Real Estate Gmbh | Method for producing RNA compositions |
EP3283125B1 (en) | 2015-04-17 | 2021-12-29 | CureVac Real Estate GmbH | Lyophilization of rna |
SG10201907164SA (en) | 2015-04-22 | 2019-09-27 | Curevac Ag | Rna containing composition for treatment of tumor diseases |
ES2897823T3 (en) | 2015-04-30 | 2022-03-02 | Curevac Ag | Immobilized poly(N)polymerase |
SG11201708681SA (en) | 2015-04-30 | 2017-11-29 | Curevac Ag | Method for in vitro transcription using an immobilized restriction enzyme |
DK3294885T3 (en) | 2015-05-08 | 2020-08-10 | Curevac Real Estate Gmbh | METHOD OF PREPARING RNA |
US11559570B2 (en) | 2015-05-15 | 2023-01-24 | CureVac SE | Prime-boost regimens involving administration of at least one mRNA construct |
CN107530448A (en) | 2015-05-20 | 2018-01-02 | 库瑞瓦格股份公司 | Include long-chain RNA dry powder composite |
SG11201708540VA (en) | 2015-05-20 | 2017-12-28 | Curevac Ag | Dry powder composition comprising long-chain rna |
DE22190069T1 (en) | 2015-05-29 | 2023-03-02 | Curevac Real Estate Gmbh | PROCESS FOR RNA PREPARATION AND PURIFICATION WITH AT LEAST ONE TANGENTIAL FLOW FILTRATION STEP |
US11608513B2 (en) | 2015-05-29 | 2023-03-21 | CureVac SE | Method for adding cap structures to RNA using immobilized enzymes |
WO2016203025A1 (en) | 2015-06-17 | 2016-12-22 | Curevac Ag | Vaccine composition |
EP4239080A3 (en) | 2015-07-01 | 2023-11-01 | CureVac Manufacturing GmbH | Method for analysis of an rna molecule |
WO2017009376A1 (en) | 2015-07-13 | 2017-01-19 | Curevac Ag | Method of producing rna from circular dna and corresponding template dna |
EP3331555A1 (en) | 2015-08-05 | 2018-06-13 | CureVac AG | Epidermal mrna vaccine |
EP3332019B1 (en) | 2015-08-07 | 2019-12-18 | CureVac AG | Process for the in vivo production of rna in a host cell |
EP3825407A1 (en) | 2015-08-10 | 2021-05-26 | CureVac Real Estate GmbH | Method of increasing the replication of a circular dna molecule |
EP3341482B1 (en) | 2015-08-28 | 2022-07-06 | CureVac AG | Artificial nucleic acid molecules |
US11225682B2 (en) | 2015-10-12 | 2022-01-18 | Curevac Ag | Automated method for isolation, selection and/or detection of microorganisms or cells comprised in a solution |
WO2017081110A1 (en) | 2015-11-09 | 2017-05-18 | Curevac Ag | Rotavirus vaccines |
WO2017081082A2 (en) | 2015-11-09 | 2017-05-18 | Curevac Ag | Optimized nucleic acid molecules |
WO2017108087A1 (en) | 2015-12-21 | 2017-06-29 | Curevac Ag | Inlay for a culture plate and corresponding method for preparing a culture plate system with such inlay |
SG11201804398XA (en) | 2015-12-22 | 2018-07-30 | Curevac Ag | Method for producing rna molecule compositions |
EP3394280A1 (en) | 2015-12-23 | 2018-10-31 | CureVac AG | Method of rna in vitro transcription using a buffer containing a dicarboxylic acid or tricarboxylic acid or a salt thereof |
WO2017137095A1 (en) | 2016-02-12 | 2017-08-17 | Curevac Ag | Method for analyzing rna |
US20190049414A1 (en) | 2016-02-15 | 2019-02-14 | Curevac Ag | Method for analyzing by-products of rna in vitro transcription |
SG11201806340YA (en) | 2016-02-17 | 2018-09-27 | Curevac Ag | Zika virus vaccine |
US11920174B2 (en) | 2016-03-03 | 2024-03-05 | CureVac SE | RNA analysis by total hydrolysis and quantification of released nucleosides |
US20190177714A1 (en) | 2016-03-24 | 2019-06-13 | Curevac Ag | Immobilized inorganic pyrophosphatase (ppase) |
WO2017182634A1 (en) | 2016-04-22 | 2017-10-26 | Curevac Ag | Rna encoding a tumor antigen |
WO2017186928A1 (en) | 2016-04-29 | 2017-11-02 | Curevac Ag | Rna encoding an antibody |
US20210162037A1 (en) | 2016-05-04 | 2021-06-03 | Curevac Ag | Influenza mrna vaccines |
US20180126003A1 (en) | 2016-05-04 | 2018-05-10 | Curevac Ag | New targets for rna therapeutics |
WO2017191264A1 (en) | 2016-05-04 | 2017-11-09 | Curevac Ag | Nucleic acid molecules and uses thereof |
WO2017191274A2 (en) | 2016-05-04 | 2017-11-09 | Curevac Ag | Rna encoding a therapeutic protein |
US20190194760A1 (en) | 2016-05-25 | 2019-06-27 | Curevac Ag | Novel biomarkers |
EP3468608A1 (en) | 2016-06-09 | 2019-04-17 | CureVac AG | Hybrid carriers for nucleic acid cargo |
EP3468613A1 (en) | 2016-06-09 | 2019-04-17 | CureVac AG | Hybrid carriers for nucleic acid cargo |
US20190336608A1 (en) | 2016-06-09 | 2019-11-07 | Curevac Ag | Cationic carriers for nucleic acid delivery |
US20190381180A1 (en) | 2016-06-09 | 2019-12-19 | Curevac Ag | Hybrid carriers for nucleic acid cargo |
CA3025812A1 (en) | 2016-08-19 | 2018-02-22 | Curevac Ag | Rna for cancer therapy |
KR20190093816A (en) | 2016-10-26 | 2019-08-26 | 큐어백 아게 | Lipid nanoparticle mRNA vaccine |
WO2018096179A1 (en) | 2016-11-28 | 2018-05-31 | Curevac Ag | Method for purifying rna |
WO2018104540A1 (en) | 2016-12-08 | 2018-06-14 | Curevac Ag | Rnas for wound healing |
EP3808380A1 (en) | 2016-12-08 | 2021-04-21 | CureVac AG | Rna for treatment or prophylaxis of a liver disease |
US11141476B2 (en) | 2016-12-23 | 2021-10-12 | Curevac Ag | MERS coronavirus vaccine |
EP3558354A1 (en) | 2016-12-23 | 2019-10-30 | CureVac AG | Lassa virus vaccine |
US11524066B2 (en) | 2016-12-23 | 2022-12-13 | CureVac SE | Henipavirus vaccine |
CN110392577A (en) | 2017-03-17 | 2019-10-29 | 库尔维科公司 | For combining the RNA vaccine and immunologic test point inhibitor of anti-cancer therapies |
CN110914433A (en) | 2017-03-24 | 2020-03-24 | 库尔维科公司 | Nucleic acids encoding CRISPR-associated proteins and uses thereof |
WO2018211038A1 (en) | 2017-05-17 | 2018-11-22 | Curevac Ag | Method for determining at least one quality parameter of an rna sample |
US10988754B2 (en) | 2017-07-04 | 2021-04-27 | Cure Vac AG | Nucleic acid molecules |
US11602557B2 (en) | 2017-08-22 | 2023-03-14 | Cure Vac SE | Bunyavirales vaccine |
CA3073634A1 (en) | 2017-10-19 | 2019-04-25 | Curevac Ag | Novel artificial nucleic acid molecules |
US11692002B2 (en) | 2017-11-08 | 2023-07-04 | CureVac SE | RNA sequence adaptation |
EP3723796A1 (en) | 2017-12-13 | 2020-10-21 | CureVac AG | Flavivirus vaccine |
SG11202005760PA (en) | 2017-12-21 | 2020-07-29 | Curevac Ag | Linear double stranded dna coupled to a single support or a tag and methods for producing said linear double stranded dna |
EP3773702A2 (en) | 2018-04-05 | 2021-02-17 | CureVac AG | Novel yellow fever nucleic acid molecules for vaccination |
BR112020020933A2 (en) | 2018-04-17 | 2021-04-06 | Curevac Ag | INNOVATIVE RSV RNA MOLECULES AND VACCINATION COMPOSITIONS |
EP3813874A1 (en) | 2018-06-27 | 2021-05-05 | CureVac AG | Novel lassa virus rna molecules and compositions for vaccination |
US20210261897A1 (en) | 2018-06-28 | 2021-08-26 | Curevac Ag | Bioreactor for rna in vitro transcription |
TW202039534A (en) | 2018-12-14 | 2020-11-01 | 美商美國禮來大藥廠 | Kras variant mrna molecules |
EP3897702A2 (en) | 2018-12-21 | 2021-10-27 | CureVac AG | Rna for malaria vaccines |
US20220073962A1 (en) | 2018-12-21 | 2022-03-10 | Curevac Ag | Methods for rna analysis |
EP3920950A1 (en) | 2019-02-08 | 2021-12-15 | CureVac AG | Coding rna administered into the suprachoroidal space in the treatment of ophtalmic diseases |
IL293571A (en) | 2020-02-04 | 2022-08-01 | Curevac Ag | Coronavirus vaccine |
-
2016
- 2016-12-22 SG SG11201804398XA patent/SG11201804398XA/en unknown
- 2016-12-22 WO PCT/EP2016/082487 patent/WO2017109134A1/en active Application Filing
- 2016-12-22 US US16/063,999 patent/US11684665B2/en active Active
- 2016-12-22 EP EP16826337.4A patent/EP3319622B1/en not_active Revoked
- 2016-12-22 KR KR1020187020982A patent/KR20180107109A/en not_active Application Discontinuation
- 2016-12-22 EP EP20156569.4A patent/EP3701963A1/en active Pending
- 2016-12-22 CN CN201680080908.5A patent/CN108778308A/en active Pending
- 2016-12-22 CA CA3009551A patent/CA3009551C/en active Active
- 2016-12-22 JP JP2018532466A patent/JP6949845B2/en active Active
- 2016-12-22 DK DK16826337.4T patent/DK3319622T3/en active
- 2016-12-22 AU AU2016375021A patent/AU2016375021B2/en active Active
-
2018
- 2018-05-15 IL IL259378A patent/IL259378A/en unknown
-
2023
- 2023-05-11 US US18/315,781 patent/US20240100142A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CN108778308A (en) | 2018-11-09 |
WO2017109134A1 (en) | 2017-06-29 |
KR20180107109A (en) | 2018-10-01 |
AU2016375021B2 (en) | 2022-02-03 |
EP3701963A1 (en) | 2020-09-02 |
AU2016375021A1 (en) | 2018-06-07 |
US11684665B2 (en) | 2023-06-27 |
DK3319622T3 (en) | 2020-05-04 |
EP3319622B1 (en) | 2020-02-12 |
JP6949845B2 (en) | 2021-10-13 |
CA3009551C (en) | 2022-12-13 |
CA3009551A1 (en) | 2017-06-29 |
IL259378A (en) | 2018-07-31 |
US20190083602A1 (en) | 2019-03-21 |
JP2019503678A (en) | 2019-02-14 |
EP3319622A1 (en) | 2018-05-16 |
US20240100142A1 (en) | 2024-03-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SG11201804398XA (en) | Method for producing rna molecule compositions | |
SG11201809912UA (en) | Hybrid carriers for nucleic acid cargo | |
SG11201811431VA (en) | Multispecific antibodies against cd40 and cd137 | |
SG11201903830TA (en) | Blockade of cd7 expression and chimeric antigen receptors for immunotherapy of t-cell malignancies | |
SG11201804373VA (en) | Compositions and methods for immunooncology | |
SG11201407580YA (en) | Composition comprising two antibodies engineered to have reduced and increased effector function | |
SG11201407546QA (en) | Novel ring-substituted n-pyridinyl amides as kinase inhibitors | |
SG11201408261UA (en) | Syringe | |
SG11201803958WA (en) | Nucleic acids encoding repetitive amino acid sequences rich in proline and alanine residues that have low repetitive nucleotide sequences | |
SG11201407486PA (en) | Compositions and methods for modulating utrn expression | |
SG11201406903SA (en) | Cell culture compositions and methods for polypeptide production | |
SG11201908784TA (en) | Improved antigen binding receptor formats | |
SG11201408037SA (en) | Humanized anti-trka antibodies with amino acid substitutions | |
SG11201809497RA (en) | Processes for preparing phosphorodiamidate morpholino oligomers | |
SG11201906553TA (en) | Methods and reagents for synthesising polynucleotide molecules | |
SG11202000333UA (en) | Bicyclic ketone compounds and methods of use thereof | |
SG11201408224SA (en) | Novel ruthenium complexes, their use in the metathesis reactions, and a process for carrying out the metathesis reaction | |
SG11201807827VA (en) | Process for the preparation of pegylated drug-linkers and intermediates thereof | |
SG11201810429UA (en) | Anti-cd19 antibody formulations | |
SG11201810965YA (en) | 1h-pyrazolo[4,3-b]pyridines as pde1 inhibitors | |
SG11201806267QA (en) | Organic reactions carried out in aqueous solution in the presence of a hydroxyalkyl(alkyl)cellulose or an alkylcellulose | |
SG11201407988UA (en) | Process for improved opioid synthesis | |
SG11201407184PA (en) | Process for preparation of optically pure and optionally substituted 2- (1 -hydroxy- alkyl) - chromen - 4 - one derivatives and their use in preparing pharmaceuticals | |
SG11201908325PA (en) | Process for the preparation of glucuronide drug-linkers and intermediates thereof | |
SG11201809499UA (en) | Processes for preparing phosphorodiamidate morpholino oligomers |