BR112012004697B8 - método para purificar um polipeptídeo compreendendo uma região ch2/ch3 - Google Patents
método para purificar um polipeptídeo compreendendo uma região ch2/ch3Info
- Publication number
- BR112012004697B8 BR112012004697B8 BR112012004697A BR112012004697A BR112012004697B8 BR 112012004697 B8 BR112012004697 B8 BR 112012004697B8 BR 112012004697 A BR112012004697 A BR 112012004697A BR 112012004697 A BR112012004697 A BR 112012004697A BR 112012004697 B8 BR112012004697 B8 BR 112012004697B8
- Authority
- BR
- Brazil
- Prior art keywords
- polypeptide
- purifying
- region
- eluting
- protein
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23886709P | 2009-09-01 | 2009-09-01 | |
US61/238,867 | 2009-09-01 | ||
US25343809P | 2009-10-20 | 2009-10-20 | |
US61/253,438 | 2009-10-20 | ||
PCT/US2010/047448 WO2011028753A1 (en) | 2009-09-01 | 2010-09-01 | Enhanced protein purification through a modified protein a elution |
Publications (3)
Publication Number | Publication Date |
---|---|
BR112012004697A2 BR112012004697A2 (pt) | 2015-09-08 |
BR112012004697B1 BR112012004697B1 (pt) | 2021-02-09 |
BR112012004697B8 true BR112012004697B8 (pt) | 2021-05-25 |
Family
ID=43649614
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112012004697A BR112012004697B8 (pt) | 2009-09-01 | 2010-09-01 | método para purificar um polipeptídeo compreendendo uma região ch2/ch3 |
Country Status (14)
Country | Link |
---|---|
US (3) | US9428548B2 (pt) |
EP (2) | EP2473617B1 (pt) |
JP (1) | JP5787891B2 (pt) |
KR (1) | KR101764449B1 (pt) |
CN (2) | CN108409829A (pt) |
BR (1) | BR112012004697B8 (pt) |
CA (1) | CA2772653C (pt) |
ES (1) | ES2787234T3 (pt) |
HR (1) | HRP20200581T1 (pt) |
MX (1) | MX2012002565A (pt) |
PL (1) | PL2473617T3 (pt) |
RU (1) | RU2571929C2 (pt) |
SI (1) | SI2473617T1 (pt) |
WO (1) | WO2011028753A1 (pt) |
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BRPI0716762A2 (pt) | 2006-09-13 | 2013-09-24 | Abbott Lab | melhorias da cultura celular |
US8911964B2 (en) | 2006-09-13 | 2014-12-16 | Abbvie Inc. | Fed-batch method of making human anti-TNF-alpha antibody |
CA2738499A1 (en) | 2008-10-20 | 2010-04-29 | Abbott Laboratories | Viral inactivation during purification of antibodies |
EP2921501A1 (en) | 2008-10-20 | 2015-09-23 | Abbvie Inc. | Isolation and purification of antibodies using Protein A affinity chromatography |
NZ597809A (en) | 2009-08-06 | 2014-05-30 | Genentech Inc | Method to improve virus removal in protein purification |
CA2773428A1 (en) * | 2009-09-10 | 2011-03-17 | Lonza Biologics Plc | Method and system for polypeptide purification |
TR201815709T4 (tr) * | 2011-12-22 | 2018-11-21 | Hoffmann La Roche | İyon değişim membranı kromatografisi. |
JP6420756B2 (ja) * | 2012-03-28 | 2018-11-07 | ジーイー・ヘルスケア・バイオプロセス・アールアンドディ・アクチボラグ | アフィニティークロマトグラフィーマトリックス |
WO2014004103A1 (en) | 2012-06-29 | 2014-01-03 | Emd Millipore Corporation | Methods for inactivating viruses during a protein purification process |
US8921113B2 (en) | 2012-12-21 | 2014-12-30 | Dionex Corporation | Buffer kit and method of generating a linear pH gradient |
JP6285532B2 (ja) * | 2013-03-14 | 2018-02-28 | イー・エム・デイー・ミリポア・コーポレイシヨン | タンパク質aに基づくクロマトグラフィを使用するタンパク質純度を増加させる方法 |
BR112016000231A8 (pt) * | 2013-07-12 | 2019-12-31 | Genentech Inc | métodos para identificações de condições de separação com cromatografia de troca de íons e para análises de composições de polipeptídeos |
CN105722523B (zh) * | 2013-11-15 | 2022-06-14 | 豪夫迈·罗氏有限公司 | 使用环保洗涤剂的病毒灭活方法 |
KR101921552B1 (ko) * | 2014-03-10 | 2018-11-23 | 리히터 게데온 닐트. | 사전 세정 단계를 이용하는 면역글로불린 정제 |
GB2539420B (en) * | 2015-06-16 | 2021-01-13 | Cytiva Sweden Ab | Determination of chromatography conditions |
TW202016151A (zh) | 2018-06-09 | 2020-05-01 | 德商百靈佳殷格翰國際股份有限公司 | 針對癌症治療之多特異性結合蛋白 |
US11022585B2 (en) | 2019-06-09 | 2021-06-01 | Dionex Corporation | Methods and systems for optimizing buffer conditions with liquid chromatography |
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-
2010
- 2010-09-01 KR KR1020127008252A patent/KR101764449B1/ko active IP Right Grant
- 2010-09-01 SI SI201032003T patent/SI2473617T1/sl unknown
- 2010-09-01 CN CN201810100462.9A patent/CN108409829A/zh active Pending
- 2010-09-01 JP JP2012527990A patent/JP5787891B2/ja active Active
- 2010-09-01 EP EP10814394.2A patent/EP2473617B1/en not_active Revoked
- 2010-09-01 CN CN2010800389895A patent/CN102686738A/zh active Pending
- 2010-09-01 ES ES10814394T patent/ES2787234T3/es active Active
- 2010-09-01 PL PL10814394T patent/PL2473617T3/pl unknown
- 2010-09-01 US US13/393,525 patent/US9428548B2/en active Active
- 2010-09-01 MX MX2012002565A patent/MX2012002565A/es active IP Right Grant
- 2010-09-01 EP EP20159179.9A patent/EP3736338A1/en not_active Withdrawn
- 2010-09-01 BR BR112012004697A patent/BR112012004697B8/pt active IP Right Grant
- 2010-09-01 RU RU2012112536/10A patent/RU2571929C2/ru active
- 2010-09-01 WO PCT/US2010/047448 patent/WO2011028753A1/en active Application Filing
- 2010-09-01 CA CA2772653A patent/CA2772653C/en active Active
-
2020
- 2020-04-09 HR HRP20200581TT patent/HRP20200581T1/hr unknown
-
2021
- 2021-05-27 US US17/332,907 patent/US20220081466A1/en not_active Abandoned
- 2021-12-21 US US17/558,406 patent/US20220324905A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
HRP20200581T1 (hr) | 2020-07-10 |
MX2012002565A (es) | 2012-05-29 |
WO2011028753A1 (en) | 2011-03-10 |
RU2571929C2 (ru) | 2015-12-27 |
PL2473617T3 (pl) | 2020-06-29 |
JP2013503877A (ja) | 2013-02-04 |
KR101764449B1 (ko) | 2017-08-02 |
KR20120106719A (ko) | 2012-09-26 |
CN108409829A (zh) | 2018-08-17 |
CA2772653C (en) | 2019-06-25 |
US9428548B2 (en) | 2016-08-30 |
RU2012112536A (ru) | 2013-10-10 |
CN102686738A (zh) | 2012-09-19 |
EP3736338A1 (en) | 2020-11-11 |
JP5787891B2 (ja) | 2015-09-30 |
BR112012004697B1 (pt) | 2021-02-09 |
CA2772653A1 (en) | 2011-03-10 |
EP2473617A1 (en) | 2012-07-11 |
US20220324905A1 (en) | 2022-10-13 |
EP2473617B1 (en) | 2020-02-26 |
US20130041139A1 (en) | 2013-02-14 |
US20220081466A1 (en) | 2022-03-17 |
EP2473617A4 (en) | 2014-04-09 |
ES2787234T3 (es) | 2020-10-15 |
BR112012004697A2 (pt) | 2015-09-08 |
SI2473617T1 (sl) | 2020-07-31 |
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Legal Events
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B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
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B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
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B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 09/02/2021, OBSERVADAS AS CONDICOES LEGAIS. |
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Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 01/09/2010 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |