CA2372813A1 - Biosynthetic binding protein for cancer marker - Google Patents
Biosynthetic binding protein for cancer marker Download PDFInfo
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- CA2372813A1 CA2372813A1 CA002372813A CA2372813A CA2372813A1 CA 2372813 A1 CA2372813 A1 CA 2372813A1 CA 002372813 A CA002372813 A CA 002372813A CA 2372813 A CA2372813 A CA 2372813A CA 2372813 A1 CA2372813 A1 CA 2372813A1
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Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3015—Breast
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83196792A | 1992-02-06 | 1992-02-06 | |
| US07/831,967 | 1992-02-06 | ||
| CA002129663A CA2129663C (en) | 1992-02-06 | 1993-02-05 | Biosynthetic binding protein for cancer marker |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002129663A Division CA2129663C (en) | 1992-02-06 | 1993-02-05 | Biosynthetic binding protein for cancer marker |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2372813A1 true CA2372813A1 (en) | 1993-08-19 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002372813A Withdrawn CA2372813A1 (en) | 1992-02-06 | 1993-02-05 | Biosynthetic binding protein for cancer marker |
| CA002129663A Expired - Lifetime CA2129663C (en) | 1992-02-06 | 1993-02-05 | Biosynthetic binding protein for cancer marker |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002129663A Expired - Lifetime CA2129663C (en) | 1992-02-06 | 1993-02-05 | Biosynthetic binding protein for cancer marker |
Country Status (8)
| Country | Link |
|---|---|
| US (6) | US5534254A (enExample) |
| EP (3) | EP0625200B1 (enExample) |
| JP (8) | JPH08500962A (enExample) |
| AT (3) | ATE419355T1 (enExample) |
| AU (1) | AU675929B2 (enExample) |
| CA (2) | CA2372813A1 (enExample) |
| DE (3) | DE69334351D1 (enExample) |
| WO (1) | WO1993016185A2 (enExample) |
Families Citing this family (1457)
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| US7838216B1 (en) * | 1986-03-05 | 2010-11-23 | The United States Of America, As Represented By The Department Of Health And Human Services | Human gene related to but distinct from EGF receptor gene |
| US5869620A (en) * | 1986-09-02 | 1999-02-09 | Enzon, Inc. | Multivalent antigen-binding proteins |
| US20050058638A1 (en) * | 1987-05-21 | 2005-03-17 | Huston James S. | Biosynthetic binding proteins for immuno-targeting |
| WO1990005144A1 (en) * | 1988-11-11 | 1990-05-17 | Medical Research Council | Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors |
| DE69233068T2 (de) * | 1991-02-27 | 2004-01-22 | Micromet Ag | Serin-reiche peptidlinker |
| KR100334695B1 (ko) * | 1991-08-05 | 2002-04-27 | 리차아드제이마세이 | 표적화된 촉매 단백질에 의해 활성화되는 선구 약제 |
| US6027725A (en) * | 1991-11-25 | 2000-02-22 | Enzon, Inc. | Multivalent antigen-binding proteins |
| US20070031931A1 (en) * | 1992-02-06 | 2007-02-08 | Chiron Corporation | Biosynthetic binding proteins for immuno-targeting |
| ATE419355T1 (de) * | 1992-02-06 | 2009-01-15 | Novartis Vaccines & Diagnostic | Marker für krebs und biosynthetisches bindeprotein dafür |
| US7754211B2 (en) * | 1992-04-10 | 2010-07-13 | Research Development Foundation | Immunotoxins directed against c-erbB-2(HER-2/neu) related surface antigens |
| US20080152586A1 (en) * | 1992-09-25 | 2008-06-26 | Avipep Pty Limited | High avidity polyvalent and polyspecific reagents |
| WO1994012520A1 (en) * | 1992-11-20 | 1994-06-09 | Enzon, Inc. | Linker for linked fusion polypeptides |
| EP0672142B1 (en) * | 1992-12-04 | 2001-02-28 | Medical Research Council | Multivalent and multispecific binding proteins, their manufacture and use |
| GB9225453D0 (en) | 1992-12-04 | 1993-01-27 | Medical Res Council | Binding proteins |
| AU680685B2 (en) | 1993-09-22 | 1997-08-07 | Medical Research Council | Retargeting antibodies |
| US5753225A (en) * | 1993-12-03 | 1998-05-19 | The Regents Of The University Of California | Antibodies that mimic actions of neurotrophins |
| IT1264083B1 (it) * | 1993-12-10 | 1996-09-10 | Enea Ente Nuove Tec | Procedimento per la produzione in piante di anticorpi ingegnerizzati, anticorpi prodotti e loro uso in diagnosi e terapia. |
| US5763733A (en) * | 1994-10-13 | 1998-06-09 | Enzon, Inc. | Antigen-binding fusion proteins |
| US6514942B1 (en) * | 1995-03-14 | 2003-02-04 | The Board Of Regents, The University Of Texas System | Methods and compositions for stimulating T-lymphocytes |
| AUPO591797A0 (en) * | 1997-03-27 | 1997-04-24 | Commonwealth Scientific And Industrial Research Organisation | High avidity polyvalent and polyspecific reagents |
| US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
| US6685940B2 (en) * | 1995-07-27 | 2004-02-03 | Genentech, Inc. | Protein formulation |
| PT896586E (pt) * | 1996-03-27 | 2007-01-31 | Genentech Inc | Anticorpos de erbb3 |
| US5968511A (en) | 1996-03-27 | 1999-10-19 | Genentech, Inc. | ErbB3 antibodies |
| US6136311A (en) | 1996-05-06 | 2000-10-24 | Cornell Research Foundation, Inc. | Treatment and diagnosis of cancer |
| DE69739856D1 (de) * | 1996-07-03 | 2010-06-02 | Genentech Inc | Agonisten für den rezeptor des hepatozyten-wachstumsfaktors und deren anwendungen |
| EP0922111B1 (en) * | 1996-07-23 | 2004-12-01 | Tanox Pharma B.V. | Induction of t cell tolerance using a soluble molecule that can simultaneously block two costimulatory pathways |
| CA2262001C (en) * | 1996-08-05 | 2003-05-20 | President And Fellows Of Harvard College | Mhc binding peptide oligomers and methods of use |
| US7371376B1 (en) | 1996-10-18 | 2008-05-13 | Genentech, Inc. | Anti-ErbB2 antibodies |
| ATE444760T1 (de) * | 1997-01-13 | 2009-10-15 | Univ Emory | Glutathion zur behandlung von influenzainfektionen |
| WO1998033809A1 (en) * | 1997-01-31 | 1998-08-06 | The General Hospital Corporation | Compositions and methods for imaging gene expression |
| US5986065A (en) * | 1997-03-10 | 1999-11-16 | Sunol Molecular Corporation | Antibodies for inhibiting blood coagulation and methods of use thereof |
| US7749498B2 (en) * | 1997-03-10 | 2010-07-06 | Genentech, Inc. | Antibodies for inhibiting blood coagulation and methods of use thereof |
| US20030109680A1 (en) * | 2001-11-21 | 2003-06-12 | Sunol Molecular Corporation | Antibodies for inhibiting blood coagulation and methods of use thereof |
| US20060235209A9 (en) * | 1997-03-10 | 2006-10-19 | Jin-An Jiao | Use of anti-tissue factor antibodies for treating thromboses |
| US20040009166A1 (en) * | 1997-04-30 | 2004-01-15 | Filpula David R. | Single chain antigen-binding polypeptides for polymer conjugation |
| WO1998048837A1 (en) | 1997-04-30 | 1998-11-05 | Enzon, Inc. | Polyalkylene oxide-modified single chain polypeptides |
| IL132838A (en) | 1997-06-13 | 2004-08-31 | Genentech Inc | Protein recovery by chromatography followed by filtration upon a charged layer |
| US6172213B1 (en) | 1997-07-02 | 2001-01-09 | Genentech, Inc. | Anti-IgE antibodies and method of improving polypeptides |
| US5994511A (en) * | 1997-07-02 | 1999-11-30 | Genentech, Inc. | Anti-IgE antibodies and methods of improving polypeptides |
| FR2766826B1 (fr) * | 1997-08-04 | 2001-05-18 | Pasteur Institut | Vecteurs derives d'anticorps pour le transfert de substances dans les cellules |
| US6737249B1 (en) * | 1997-08-22 | 2004-05-18 | Genentech, Inc. | Agonist antibodies |
| ZA9811162B (en) | 1997-12-12 | 2000-06-07 | Genentech Inc | Treatment with anti-ERBB2 antibodies. |
| EP1947119A3 (en) | 1997-12-12 | 2012-12-19 | Genentech, Inc. | Treatment of cancer with anti-erb2 antibodies in combination with a chemotherapeutic agent |
| EP1941905A1 (en) | 1998-03-27 | 2008-07-09 | Genentech, Inc. | APO-2 Ligand-anti-her-2 antibody synergism |
| DE19819846B4 (de) * | 1998-05-05 | 2016-11-24 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Multivalente Antikörper-Konstrukte |
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| ATE419355T1 (de) * | 1992-02-06 | 2009-01-15 | Novartis Vaccines & Diagnostic | Marker für krebs und biosynthetisches bindeprotein dafür |
| WO1993021319A1 (en) * | 1992-04-08 | 1993-10-28 | Cetus Oncology Corporation | HUMANIZED C-erbB-2 SPECIFIC ANTIBODIES |
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1993
- 1993-02-05 AT AT04078206T patent/ATE419355T1/de not_active IP Right Cessation
- 1993-02-05 AU AU36122/93A patent/AU675929B2/en not_active Expired
- 1993-02-05 EP EP93904938A patent/EP0625200B1/en not_active Expired - Lifetime
- 1993-02-05 DE DE69334351T patent/DE69334351D1/de not_active Expired - Lifetime
- 1993-02-05 JP JP5514197A patent/JPH08500962A/ja not_active Withdrawn
- 1993-02-05 EP EP08075574A patent/EP1997894B1/en not_active Expired - Lifetime
- 1993-02-05 CA CA002372813A patent/CA2372813A1/en not_active Withdrawn
- 1993-02-05 DE DE69333807T patent/DE69333807T2/de not_active Expired - Lifetime
- 1993-02-05 WO PCT/US1993/001055 patent/WO1993016185A2/en not_active Ceased
- 1993-02-05 DE DE69334255T patent/DE69334255D1/de not_active Expired - Lifetime
- 1993-02-05 AT AT93904938T patent/ATE295420T1/de not_active IP Right Cessation
- 1993-02-05 EP EP04078206A patent/EP1514934B1/en not_active Expired - Lifetime
- 1993-02-05 AT AT08075574T patent/ATE503496T1/de not_active IP Right Cessation
- 1993-02-05 CA CA002129663A patent/CA2129663C/en not_active Expired - Lifetime
- 1993-10-07 US US08/133,804 patent/US5534254A/en not_active Expired - Lifetime
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1994
- 1994-12-12 US US08/356,786 patent/US5877305A/en not_active Expired - Lifetime
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1995
- 1995-06-05 US US08/461,386 patent/US5837846A/en not_active Expired - Lifetime
- 1995-06-05 US US08/461,838 patent/US5753204A/en not_active Expired - Lifetime
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2001
- 2001-06-21 US US09/887,853 patent/US7138497B2/en not_active Expired - Fee Related
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2003
- 2003-03-24 JP JP2003081465A patent/JP4236493B2/ja not_active Expired - Lifetime
- 2003-10-10 US US10/684,237 patent/US20060147444A1/en not_active Abandoned
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2004
- 2004-06-16 JP JP2004178961A patent/JP2005104965A/ja not_active Withdrawn
- 2004-09-07 JP JP2004260280A patent/JP2005168489A/ja not_active Withdrawn
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2007
- 2007-06-20 JP JP2007163220A patent/JP2007231027A/ja not_active Withdrawn
- 2007-06-20 JP JP2007163221A patent/JP2007228979A/ja not_active Withdrawn
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2008
- 2008-08-15 JP JP2008209387A patent/JP2008289500A/ja not_active Withdrawn
- 2008-08-15 JP JP2008209384A patent/JP2009035558A/ja not_active Withdrawn
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